EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27597531	Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.	Mol Carcinog	2017 Mar	L??vesque N	doi: 10.1002/mc.22568
30343310	Methylenetetrahydrofolate Dehydrogenase 1 Silencing Expedites the Apoptosis of Non-Small Cell Lung Cancer Cells via Modulating DNA Methylation.	Med Sci Monit	2018 Oct 21	Ding K	doi: 10.12659/MSM.910265.
28968444	One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation.	PLoS One	2017 Oct 2	Moruzzi S	doi: 10.1371/journal.pone.0185792
21349258	Folate and choline metabolism gene variants and development of uterine cervical carcinoma.	Clin Biochem	2011 Jun	Mostowska A	doi: 10.1016/j.clinbiochem.2011.02.007
21090237	[Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia].	Mol Biol (Mosk)	2010 Sep-Oct	Vaner AS	-
23894459	Association of methylenetetrahydrofolate dehydrogenase 1 polymorphisms with cancer: a meta-analysis.	PLoS One	2013 Jul 19	Zhang H	doi: 10.1371/journal.pone.0069366
24197977	Lack of association between methylenetetrahydrofolate dehydrogenase 1 G1958A polymorphism and prostate cancer risk: a meta-analysis.	Tumour Biol	2014 Mar	Liu G	doi: 10.1007/s13277-013-1269-y
19649727	Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer.	Mol Biol Rep	2010 Jan	Kruszyna	doi: 10.1007/s11033-009-9643-y
24287951	Lack of association between MTHFD1 G401A polymorphism and ovarian cancer susceptibility.	Tumour Biol	2014 Apr	Cui Y	doi: 10.1007/s13277-013-1446-z

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr14	64388296	5'Flank	novel		0.18
BLCA	chr14	64411100	Missense_Mutation	novel	R46T	0.12
BLCA	chr14	64411134	Silent	novel	L57L	0.15
BLCA	chr14	64454839	Silent	rs565206627	S894S	0.26
BLCA	chr14	64427345	Missense_Mutation	novel	P379L	0.19
BLCA	chr14	64449455	Missense_Mutation	novel	E764K	0.07
BLCA	chr14	64424854	Missense_Mutation	novel	E260K	0.39
BLCA	chr14	64431583	Missense_Mutation	NA	L455F	0.61
BLCA	chr14	64442315	Missense_Mutation	NA	I683M	0.39
BRCA	chr14	64454802	Missense_Mutation	novel	T882I	0.38
BRCA	chr14	64431546	Silent	NA	L442L	0.26
BRCA	chr14	64417969	Missense_Mutation	novel	W187L	0.1
BRCA	chr14	64424884	Missense_Mutation	NA	P270A	0.34
BRCA	chr14	64449384	Intron	novel		0.3
BRCA	chr14	64458213	Splice_Site	NA	X907_splice	0.26
BRCA	chr14	64440142	Missense_Mutation	NA	S564C	0.7
BRCA	chr14	64388403	5'UTR	novel		0.13
BRCA	chr14	64412471	Splice_Site	NA	X63_splice	0.15
BRCA	chr14	64412521	Missense_Mutation	NA	S79C	0.22
BRCA	chr14	64427447	Missense_Mutation	NA	S413F	0.94
BRCA	chr14	64427449	Nonsense_Mutation	NA	Q414*	0.93
BRCA	chr14	64431833	Missense_Mutation	NA	F489Y	0.69
BRCA	chr14	64400853	Silent	NA	F34F	0.46
BRCA	chr14	64424858	Missense_Mutation	NA	A261V	0.14
CESC	chr14	64431538	Missense_Mutation	NA	L440F	0.58
CESC	chr14	64430211	Missense_Mutation	NA	Q431R	0.57
CESC	chr14	64415431	Missense_Mutation	novel	S105L	0.11
CHOL	chr14	64459879	3'UTR	novel		0.45
COAD	chr14	64388326	5'Flank	novel		0.29
COAD	chr14	64440146	Silent	NA	V565V	0.26
COAD	chr14	64388460	Missense_Mutation	novel	E11D	0.38
COAD	chr14	64427429	Missense_Mutation	novel	A407V	0.36
COAD	chr14	64431593	Missense_Mutation	novel	A458V	0.37
COAD	chr14	64454822	Missense_Mutation	NA	R889C	0.13
COAD	chr14	64442303	Frame_Shift_Ins	novel	N682*	0.41
COAD	chr14	64441453	Missense_Mutation	novel	E628D	0.31
COAD	chr14	64442096	Missense_Mutation	rs765252643	A643T	0.25
COAD	chr14	64415485	Missense_Mutation	novel	D123G	0.05
COAD	chr14	64440238	Missense_Mutation	NA	K596T	0.08
COAD	chr14	64431595	Missense_Mutation	NA	A459T	0.37
COAD	chr14	64424808	Frame_Shift_Ins	novel	*P247Tfs9**	0.28
COAD	chr14	64440167	Silent	novel	V572V	0.26
DLBC	chr14	64454731	Silent	novel	G858G	0.36
ESCA	chr14	64453832	Nonsense_Mutation	novel	Q846*	0.18
GBM	chr14	64449548	Missense_Mutation	novel	A795T	0.07
GBM	chr14	64415464	Missense_Mutation	NA	N116S	0.34
GBM	chr14	64454780	Missense_Mutation	novel	P875A	0.07
GBM	chr14	64458281	Frame_Shift_Ins	novel	*E929Dfs20**	0.08
GBM	chr14	64424930	Missense_Mutation	novel	Q285R	0.16
HNSC	chr14	64431593	Missense_Mutation	novel	A458V	0.24
HNSC	chr14	64426194	Splice_Site	novel	X376_splice	0.12
HNSC	chr14	64440239	Silent	novel	K596K	0.29
HNSC	chr14	64449536	Frame_Shift_Del	novel	*G792Afs5**	0.26
HNSC	chr14	64435614	Missense_Mutation	novel	E514Q	0.15
HNSC	chr14	64415392	Missense_Mutation	novel	S92C	0.23
HNSC	chr14	64427412	Silent	novel	L401L	0.05
HNSC	chr14	64442137	Silent	novel	L656L	0.49
HNSC	chr14	64440151	Frame_Shift_Del	novel	*E568Cfs24**	0.47
HNSC	chr14	64388298	5'Flank	novel		0.5
HNSC	chr14	64424833	Missense_Mutation	novel	V253L	0.09
HNSC	chr14	64388287	5'Flank	rs577974081		0.21
HNSC	chr14	64424895	Silent	rs769272465	G273G	0.26
KIRC	chr14	64388462	Missense_Mutation	NA	I12N	0.7
KIRP	chr14	64448260	Frame_Shift_Del	novel	*Q741Hfs2**	0.34
KIRP	chr14	64448307	Missense_Mutation	NA	N757H	0.2
KIRP	chr14	64458224	Missense_Mutation	NA	M910T	0.44
KIRP	chr14	64449312	Intron	novel		0.8
LGG	chr14	64412521	Missense_Mutation	novel	S79F	0.36
LGG	chr14	64449511	Silent	novel	A782A	0.41
LIHC	chr14	64454741	Missense_Mutation	novel	I862L	0.25
LIHC	chr14	64419887	Missense_Mutation	NA	G230V	0.53
LIHC	chr14	64448237	Silent	NA	K733K	0.06
LIHC	chr14	64453838	Missense_Mutation	novel	K848Q	0.42
LUAD	chr14	64415393	Frame_Shift_Del	novel	*V94Wfs15**	0.1
LUAD	chr14	64449433	Splice_Region	novel		0.41
LUAD	chr14	64415433	Missense_Mutation	novel	E106Q	0.1
LUAD	chr14	64444703	Missense_Mutation	NA	G716E	0.05
LUAD	chr14	64439167	Missense_Mutation	rs776643263	R557W	0.12
LUSC	chr14	64415377	Missense_Mutation	novel	S87C	0.48
LUSC	chr14	64415363	Missense_Mutation	NA	M82I	0.12
LUSC	chr14	64440270	Splice_Region	novel		0.12
LUSC	chr14	64454825	Missense_Mutation	rs750902671	D890N	0.06
LUSC	chr14	64431627	Silent	NA	T469T	0.19
LUSC	chr14	64442060	Missense_Mutation	NA	P631A	0.24
LUSC	chr14	64424865	Missense_Mutation	novel	E263D	0.41
LUSC	chr14	64431567	Silent	novel	I449I	0.43
OV	chr14	64388415	5'UTR	novel		0.25
OV	chr14	64427345	Missense_Mutation	novel	P379Q	0.06
OV	chr14	64454807	Missense_Mutation	novel	F884I	0.08
OV	chr14	64449498	Missense_Mutation	novel	G778V	0.06
OV	chr14	64458242	Frame_Shift_Ins	novel	*P917Afs5**	0.07
OV	chr14	64419824	Missense_Mutation	NA	G209A	0.14
PAAD	chr14	64388263	5'Flank	novel		0.1
PRAD	chr14	64424801	Splice_Region	novel		0.2
READ	chr14	64453825	Silent	NA	P843P	0.19
READ	chr14	64449429	Intron	novel		0.42
SARC	chr14	64417960	Frame_Shift_Ins	novel	*L185Afs20**	0.24
SKCM	chr14	64454869	Silent	NA	V904V	0.33
SKCM	chr14	64388296	5'Flank	novel		0.63
SKCM	chr14	64425783	Nonsense_Mutation	NA	W303*	0.33
SKCM	chr14	64431546	Silent	NA	L442L	0.79
SKCM	chr14	64444714	Missense_Mutation	novel	P720S	0.32
SKCM	chr14	64388326	5'Flank	novel		0.22
SKCM	chr14	64426071	Nonsense_Mutation	novel	R336*	0.34
SKCM	chr14	64442330	Silent	rs773494969	S688S	0.56
SKCM	chr14	64430224	Missense_Mutation	NA	M435I	0.46
SKCM	chr14	64388235	5'Flank	novel		0.38
SKCM	chr14	64412512	Missense_Mutation	NA	T76I	0.16
SKCM	chr14	64430228	Missense_Mutation	NA	E437K	0.1
SKCM	chr14	64454740	Silent	novel	P861P	0.43
SKCM	chr14	64440172	Missense_Mutation	NA	A574V	0.36
SKCM	chr14	64415440	Missense_Mutation	NA	S108F	0.88
SKCM	chr14	64426062	Missense_Mutation	NA	K333E	0.41
SKCM	chr14	64442386	Missense_Mutation	novel	H707L	0.1
SKCM	chr14	64442387	Silent	rs376487146	H707H	0.1
SKCM	chr14	64431585	Silent	rs747837982	L455L	0.62
SKCM	chr14	64418026	Splice_Site	NA	X205_splice	0.1
STAD	chr14	64388399	5'UTR	novel		0.33
STAD	chr14	64424835	Silent	novel	V253V	0.13
STAD	chr14	64449559	Silent	novel	L798L	0.5
STAD	chr14	64454825	Missense_Mutation	rs750902671	D890N	0.25
STAD	chr14	64427342	Missense_Mutation	novel	T378I	0.41
STAD	chr14	64430211	Missense_Mutation	NA	Q431R	0.24
STAD	chr14	64400831	Missense_Mutation	NA	L27S	0.3
STAD	chr14	64442083	Silent	rs143959060	P638P	0.21
THCA	chr14	64442112	Missense_Mutation	NA	S648F	0.07
THYM	chr14	64388375	5'UTR	novel		0.12
THYM	chr14	64448253	In_Frame_Del	novel	K739_Q741del	0.37
UCEC	chr14	64426177	Missense_Mutation	NA	Y371C	0.26
UCEC	chr14	64419901	Missense_Mutation	rs202026193	D235N	0.27
UCEC	chr14	64440157	Missense_Mutation	novel	I569S	0.05
UCEC	chr14	64442131	Silent	NA	I654I	0.4
UCEC	chr14	64449360	Intron	novel		0.37
UCEC	chr14	64400860	Missense_Mutation	rs111509453	R37C	0.26
UCEC	chr14	64388266	5'Flank	rs753432071		0.34
UCEC	chr14	64419889	Missense_Mutation	novel	A231T	0.31
UCEC	chr14	64454791	Missense_Mutation	novel	K878N	0.29
UCEC	chr14	64454822	Missense_Mutation	NA	R889C	0.5
UCEC	chr14	64424808	Frame_Shift_Ins	novel	*P247Tfs9**	0.36
UCEC	chr14	64454874	Missense_Mutation	rs371285981	T906M	0.21
UCEC	chr14	64388196	5'Flank	novel		0.47
UCEC	chr14	64442402	Splice_Region	rs150796086	T712T	0.27
UCEC	chr14	64449379	Intron	novel		0.4
UCEC	chr14	64412521	Missense_Mutation	novel	S79F	0.35
UCEC	chr14	64442095	Silent	rs761913080	I642I	0.4
UCEC	chr14	64459870	3'UTR	novel		0.45
UCEC	chr14	64411124	Missense_Mutation	novel	N54I	0.23
UCEC	chr14	64449530	Missense_Mutation	novel	A789T	0.1
UCEC	chr14	64388182	5'Flank	novel		0.38
UCEC	chr14	64440270	Splice_Region	novel		0.41
UCEC	chr14	64442331	Missense_Mutation	rs749310643	G689S	0.38
UCEC	chr14	64449437	Splice_Region	novel		0.31
UCEC	chr14	64427437	Nonsense_Mutation	NA	R410*	0.35
UCEC	chr14	64454787	Frame_Shift_Del	novel	*G879Vfs25**	0.15
UCEC	chr14	64426178	Silent	rs187474222	Y371Y	0.3
UCEC	chr14	64440145	Missense_Mutation	novel	V565A	0.24
UCEC	chr14	64448276	Silent	novel	R746R	0.41
UCEC	chr14	64454822	Missense_Mutation	NA	R889C	0.14
UCEC	chr14	64417920	Missense_Mutation	novel	V171I	0.43
UCEC	chr14	64412500	Nonsense_Mutation	novel	L72*	0.38
UCEC	chr14	64417926	Missense_Mutation	rs141210410	R173C	0.42
UCEC	chr14	64459821	3'UTR	novel		0.33
UCEC	chr14	64411122	Silent	novel	I53I	0.16
UCEC	chr14	64442132	Missense_Mutation	novel	A655T	0.08
UCEC	chr14	64458240	Silent	novel	T915T	0.32
UCEC	chr14	64415741	Splice_Site	NA	X160_splice	0.42
UCEC	chr14	64426139	Silent	novel	S358S	0.14
UCEC	chr14	64454831	Missense_Mutation	novel	R892C	0.27
UCEC	chr14	64449384	Intron	novel		0.5
UCEC	chr14	64388303	5'Flank	novel		0.32
UCEC	chr14	64426162	Missense_Mutation	rs540581926	R366Q	0.48
UCEC	chr14	64442397	Missense_Mutation	novel	P711S	0.31
UCEC	chr14	64449511	Silent	novel	A782A	0.51
UCEC	chr14	64448304	Missense_Mutation	NA	V756M	0.32
UCEC	chr14	64439132	Missense_Mutation	NA	T545M	0.11
UCEC	chr14	64417900	Missense_Mutation	rs748390032	A164V	0.37
UCEC	chr14	64442110	Silent	novel	S647S	0.39

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1333	0.19769
CHOL	DEL	0.5278	0.00040262
COAD	DEL	0.286	0.050084
GBM	DEL	0.2721	5.7274e-07
KIRC	DEL	0.3788	0.0074281
KIRP	DEL	0.1667	0.085174
LGG	DEL	0.2105	1.1681e-13
MESO	DEL	0.3908	0.088547
OV	DEL	0.4922	6.0694e-08
PAAD	DEL	0.0598	0.11332
READ	DEL	0.3515	0.189

Survival Analysis

Cancer	P-value	Q-value
THYM	0.028	Kaplan-Meier Survival Analysis
STAD	0.033	Kaplan-Meier Survival Analysis
SARC	0.027	Kaplan-Meier Survival Analysis
MESO	0.00022	Kaplan-Meier Survival Analysis
ACC	0.00047	Kaplan-Meier Survival Analysis
PAAD	0.00038	Kaplan-Meier Survival Analysis
BLCA	0.022	Kaplan-Meier Survival Analysis
CESC	0.038	Kaplan-Meier Survival Analysis
LAML	0.042	Kaplan-Meier Survival Analysis
KICH	0.011	Kaplan-Meier Survival Analysis
UCEC	0.029	Kaplan-Meier Survival Analysis
LUAD	0.00012	Kaplan-Meier Survival Analysis
UVM	0.0085	Kaplan-Meier Survival Analysis
OV	0.036	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000100714 (Gene tree)
Gene ID: 4522
Gene Symbol: MTHFD1
Alias: MTHFC|MTHFD
Full Name: methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 75,427 bases
Position: chr14:64,388,031-64,463,457
Accession: 7432
RBP type: non-canonical RBP
Summary: This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000555709	MTHFD1-211	803	-	ENSP00000450560	261 (aa)	-	P11586
ENST00000557370	MTHFD1-215	571	-	ENSP00000477199	107 (aa)	-	V9GYY3
ENST00000555858	MTHFD1-212	386	-	-	- (aa)	-	-
ENST00000554057	MTHFD1-205	560	-	-	- (aa)	-	-
ENST00000216605	MTHFD1-201	3136	-	ENSP00000216605	935 (aa)	-	P11586
ENST00000554768	MTHFD1-209	563	-	ENSP00000477501	25 (aa)	-	V9GZ78
ENST00000555252	MTHFD1-210	2053	-	-	- (aa)	-	-
ENST00000554353	MTHFD1-206	556	-	-	- (aa)	-	-
ENST00000556284	MTHFD1-213	932	-	-	- (aa)	-	-
ENST00000557539	MTHFD1-216	509	-	ENSP00000476468	68 (aa)	-	V9GY75
ENST00000554739	MTHFD1-208	688	-	ENSP00000477359	23 (aa)	-	V9GZ32
ENST00000553391	MTHFD1-203	568	-	-	- (aa)	-	-
ENST00000545908	MTHFD1-202	6814	-	ENSP00000438588	1020 (aa)	-	F5H2F4
ENST00000554677	MTHFD1-207	783	-	-	- (aa)	-	-
ENST00000556771	MTHFD1-214	813	-	-	- (aa)	-	-
ENST00000553405	MTHFD1-204	833	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100714's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00670	One carbon pool by folate	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100714	Eosinophils	6.4970000E-005	-
ENSG00000100714	Platelet Function Tests	2.3500000E-006	-
ENSG00000100714	Neuropsychological Tests	8E-7	19734545

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100714	rs10498514	14	64432337	?	Cognitive performance	19734545			EFO_0003926
ENSG00000100714	rs2281603	14	64459379	C	Lymphocyte counts	27863252	[0.022-0.038] unit increase	0.02984291	EFO_0004587
ENSG00000100714	rs6573559	14	64456448	T	Educational attainment (years of education)	30038396	[0.0076-0.0134] unit increase	0.0105	EFO_0004784
ENSG00000100714	rs1950902	14	64415662	?	Longevity	30294719	[1.34-1.90]	1.595	EFO_0004300
ENSG00000100714	rs3783727	14	64435010	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100714's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000105	histidine biosynthetic process	-	IEA	Process
GO:0001780	neutrophil homeostasis	-	IEA	Process
GO:0001843	neural tube closure	-	ISS	Process
GO:0004329	formate-tetrahydrofolate ligase activity	21873635.	IBA	Function
GO:0004329	formate-tetrahydrofolate ligase activity	1881876.	IDA	Function
GO:0004329	formate-tetrahydrofolate ligase activity	-	ISS	Function
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	21873635.	IBA	Function
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	1881876.	IDA	Function
GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	1881876.	IDA	Function
GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	-	ISS	Function
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	21873635.	IBA	Function
GO:0005515	protein binding	24169621.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005739	mitochondrion	3528153.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006164	purine nucleotide biosynthetic process	-	ISS	Process
GO:0006555	methionine metabolic process	-	ISS	Process
GO:0006730	one-carbon metabolic process	25633902.	IMP	Process
GO:0007507	heart development	-	ISS	Process
GO:0009069	serine family amino acid metabolic process	-	ISS	Process
GO:0009070	serine family amino acid biosynthetic process	25633902.	IMP	Process
GO:0009086	methionine biosynthetic process	25633902.	IMP	Process
GO:0009113	purine nucleobase biosynthetic process	21873635.	IBA	Process
GO:0009257	10-formyltetrahydrofolate biosynthetic process	21873635.	IBA	Process
GO:0009257	10-formyltetrahydrofolate biosynthetic process	1881876.	IDA	Process
GO:0009257	10-formyltetrahydrofolate biosynthetic process	-	ISS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019346	transsulfuration	-	IEA	Process
GO:0035999	tetrahydrofolate interconversion	1881876.	IDA	Process
GO:0035999	tetrahydrofolate interconversion	-	IEA	Process
GO:0035999	tetrahydrofolate interconversion	-	ISS	Process
GO:0046655	folic acid metabolic process	-	TAS	Process
GO:0048702	embryonic neurocranium morphogenesis	-	ISS	Process
GO:0048703	embryonic viscerocranium morphogenesis	-	ISS	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0061053	somite development	-	ISS	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.