EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr16	1501664	Missense_Mutation	rs764823412	T455A	0.45
BLCA	chr16	1509871	Missense_Mutation	NA	A817S	0.27
BLCA	chr16	1494330	Missense_Mutation	NA	H17D	0.34
BLCA	chr16	1503000	Missense_Mutation	novel	D614H	0.17
BLCA	chr16	1502119	Silent	novel	V515V	0.08
BLCA	chr16	1495519	Missense_Mutation	novel	R170L	0.27
BLCA	chr16	1506997	Silent	rs750760448	L724L	0.75
BLCA	chr16	1502950	Missense_Mutation	NA	S597L	0.09
BLCA	chr16	1502928	Splice_Region	novel		0.41
BRCA	chr16	1505501	Frame_Shift_Del	NA	*L645Rfs68**	0.21
BRCA	chr16	1494311	Silent	NA	L10L	0.56
BRCA	chr16	1500143	Missense_Mutation	novel	Q327H	0.2
BRCA	chr16	1497068	Nonsense_Mutation	NA	Q216*	0.13
BRCA	chr16	1507646	Silent	NA	L779L	0.15
BRCA	chr16	1507315	Missense_Mutation	NA	A746T	0.36
CESC	chr16	1494267	5'UTR	novel		0.21
CESC	chr16	1506303	Silent	novel	F700F	0.43
CESC	chr16	1500643	Missense_Mutation	novel	V409M	0.48
CESC	chr16	1495615	Missense_Mutation	novel	S202C	0.31
CHOL	chr16	1501467	Silent	novel	P443P	0.24
COAD	chr16	1495352	Silent	novel	S114S	0.4
COAD	chr16	1497365	Missense_Mutation	novel	E229D	0.38
COAD	chr16	1507624	Missense_Mutation	rs771006115	S772L	0.14
COAD	chr16	1509926	Missense_Mutation	rs375348828	A835V	0.22
COAD	chr16	1495467	Missense_Mutation	novel	R153W	0.32
COAD	chr16	1501435	Missense_Mutation	novel	L433V	0.4
COAD	chr16	1501726	Silent	rs372121074	G475G	0.41
COAD	chr16	1495372	Missense_Mutation	rs781593894	A121V	0.13
COAD	chr16	1495475	Silent	novel	T155T	0.32
COAD	chr16	1505495	Missense_Mutation	rs373633187	P643L	0.44
COAD	chr16	1500166	Splice_Site	NA	X334_splice	0.3
COAD	chr16	1502046	Splice_Site	novel	X491_splice	0.31
COAD	chr16	1500588	Silent	rs556246053	G390G	0.19
COAD	chr16	1499300	Silent	novel	T300T	0.23
COAD	chr16	1495604	Silent	rs773976708	A198A	0.24
COAD	chr16	1505561	Missense_Mutation	novel	V665E	0.16
COAD	chr16	1499246	Silent	rs764952387	S282S	0.35
COAD	chr16	1500417	Missense_Mutation	rs141078050	R358H	0.2
COAD	chr16	1494419	Silent	rs780539371	A46A	0.14
COAD	chr16	1501463	Frame_Shift_Del	rs758690070	*Q444Sfs63**	0.32
COAD	chr16	1494257	5'UTR	novel		0.45
COAD	chr16	1500418	Silent	NA	R358R	0.36
COAD	chr16	1501466	Missense_Mutation	NA	P443L	0.13
ESCA	chr16	1500421	Silent	rs375335497	H359H	0.23
ESCA	chr16	1495435	Missense_Mutation	rs554969175	R142Q	0.37
GBM	chr16	1500116	Silent	novel	L318L	0.23
GBM	chr16	1499312	Silent	novel	L304L	0.08
GBM	chr16	1494472	Missense_Mutation	novel	R64K	0.4
GBM	chr16	1500585	Silent	rs745894433	A389A	0.62
GBM	chr16	1494365	Silent	novel	I28I	0.08
GBM	chr16	1499332	Missense_Mutation	rs200185348	T311M	0.11
HNSC	chr16	1502735	Missense_Mutation	novel	A582S	0.28
KIRC	chr16	1507028	Missense_Mutation	NA	M735V	0.39
KIRC	chr16	1500654	Silent	rs754820309	V412V	0.33
KIRC	chr16	1502945	Silent	NA	L595L	0.29
KIRP	chr16	1500651	Silent	novel	E411E	0.2
KIRP	chr16	1500652	Missense_Mutation	novel	V412F	0.2
KIRP	chr16	1502984	Missense_Mutation	NA	Q608H	0.12
LAML	chr16	1507702	Missense_Mutation	rs767256385	R798Q	0.15
LGG	chr16	1495587	Missense_Mutation	rs781236535	V193I	0.35
LGG	chr16	1502358	Missense_Mutation	rs769532584	R536Q	0.6
LGG	chr16	1507702	Missense_Mutation	rs767256385	R798Q	0.37
LIHC	chr16	1501725	Missense_Mutation	NA	G475D	0.53
LIHC	chr16	1495383	Missense_Mutation	NA	A125P	0.54
LUAD	chr16	1500634	Missense_Mutation	novel	G406C	0.29
LUAD	chr16	1505496	Silent	novel	P643P	0.23
LUAD	chr16	1505455	Missense_Mutation	NA	G630W	0.48
LUAD	chr16	1495619	Silent	novel	L203L	0.43
LUAD	chr16	1501497	Splice_Region	novel	A453A	0.33
LUAD	chr16	1497464	Silent	NA	R262R	1
LUSC	chr16	1494470	Silent	novel	L63L	0.16
LUSC	chr16	1495602	Missense_Mutation	NA	A198T	0.33
LUSC	chr16	1509953	3'UTR	novel		0.73
LUSC	chr16	1502987	Silent	rs760147994	R609R	0.11
LUSC	chr16	1502925	Splice_Site	novel	X591_splice	0.05
LUSC	chr16	1502136	Splice_Site	novel	X521_splice	0.48
LUSC	chr16	1495550	Silent	NA	F180F	0.65
LUSC	chr16	1501668	Missense_Mutation	novel	S456C	0.14
LUSC	chr16	1495550	Missense_Mutation	NA	F180L	0.08
LUSC	chr16	1502972	Silent	novel	Y604Y	0.24
LUSC	chr16	1495503	Missense_Mutation	NA	D165Y	0.12
PAAD	chr16	1501486	Missense_Mutation	NA	A450T	0.23
PAAD	chr16	1507009	Silent	rs147404164	A728A	0.19
PCPG	chr16	1501467	Silent	rs541069927	P443P	0.61
PRAD	chr16	1506316	Nonsense_Mutation	rs756134876	Q705*	0.1
PRAD	chr16	1506990	Missense_Mutation	novel	L722P	0.29
READ	chr16	1509906	Silent	NA	K828K	0.53
READ	chr16	1506968	Missense_Mutation	NA	D715N	0.39
SARC	chr16	1495429	Missense_Mutation	novel	Q140L	0.21
SARC	chr16	1497394	Missense_Mutation	novel	A239G	0.06
SARC	chr16	1497053	Missense_Mutation	rs758024477	V211M	0.16
SKCM	chr16	1497052	Silent	rs374300390	S210S	0.41
SKCM	chr16	1506971	Missense_Mutation	NA	L716F	0.16
SKCM	chr16	1501440	Silent	rs746578156	S434S	0.14
SKCM	chr16	1495617	Missense_Mutation	novel	L203F	0.35
SKCM	chr16	1502065	Silent	novel	P497P	0.47
SKCM	chr16	1501736	Nonsense_Mutation	NA	Q479*	0.39
SKCM	chr16	1505461	Missense_Mutation	NA	T632S	0.39
SKCM	chr16	1494334	Missense_Mutation	rs777809177	A18V	0.17
SKCM	chr16	1501717	Silent	rs374682854	I472I	0.27
SKCM	chr16	1494343	Missense_Mutation	NA	S21F	0.39
SKCM	chr16	1501435	Silent	NA	L433L	0.32
SKCM	chr16	1495496	Silent	NA	A162A	0.33
SKCM	chr16	1506244	Missense_Mutation	NA	P681S	0.1
SKCM	chr16	1501693	Silent	rs764759227	P464P	0.12
SKCM	chr16	1497057	Missense_Mutation	NA	S212F	0.59
SKCM	chr16	1495501	Missense_Mutation	rs553962493	P164L	0.6
SKCM	chr16	1495502	Silent	rs780947006	P164P	0.61
SKCM	chr16	1494320	Silent	novel	R13R	0.31
SKCM	chr16	1494321	Missense_Mutation	novel	E14K	0.34
SKCM	chr16	1500437	Missense_Mutation	NA	L365F	0.27
SKCM	chr16	1499255	Silent	novel	L285L	0.35
SKCM	chr16	1494461	Silent	NA	S60S	0.15
SKCM	chr16	1495592	Silent	NA	R194R	0.43
SKCM	chr16	1495586	Silent	novel	V192V	0.48
SKCM	chr16	1502362	Silent	NA	A537A	0.38
SKCM	chr16	1507341	Silent	rs776056609	F754F	0.33
SKCM	chr16	1505598	Silent	novel	S677S	0.55
SKCM	chr16	1502979	Missense_Mutation	rs146401595	R607W	0.46
SKCM	chr16	1501672	Silent	NA	L457L	0.3
STAD	chr16	1500473	Missense_Mutation	rs200293618	R377W	0.29
STAD	chr16	1495567	Missense_Mutation	novel	R186H	0.27
STAD	chr16	1502758	Silent	novel	A589A	0.56
STAD	chr16	1501486	Missense_Mutation	NA	A450T	0.26
STAD	chr16	1506319	Missense_Mutation	rs780227352	R706C	0.16
STAD	chr16	1494533	Missense_Mutation	novel	E84D	0.4
STAD	chr16	1506292	Missense_Mutation	rs145891685	G697S	0.31
STAD	chr16	1494427	Missense_Mutation	novel	R49K	0.2
STAD	chr16	1501730	Missense_Mutation	rs572277163	V477I	0.17
STAD	chr16	1502704	Silent	NA	G571G	0.18
STAD	chr16	1506267	Silent	NA	S688S	0.41
STAD	chr16	1506269	Missense_Mutation	novel	P689L	0.29
TGCT	chr16	1494543	Missense_Mutation	novel	A88S	0.53
TGCT	chr16	1502338	Missense_Mutation	novel	E529D	0.17
UCEC	chr16	1501730	Missense_Mutation	rs572277163	V477I	0.24
UCEC	chr16	1510041	3'UTR	novel		0.71
UCEC	chr16	1494359	Silent	NA	G26G	0.31
UCEC	chr16	1509969	3'UTR	rs780730419		0.48
UCEC	chr16	1499265	Missense_Mutation	novel	V289M	0.54
UCEC	chr16	1494375	Silent	rs762117786	L32L	0.58
UCEC	chr16	1497041	Missense_Mutation	novel	L207M	0.33
UCEC	chr16	1507026	Missense_Mutation	novel	L734P	0.2
UCEC	chr16	1502761	Splice_Region	novel	P590P	0.38
UCEC	chr16	1505540	Missense_Mutation	rs147858841	A658V	0.5
UCEC	chr16	1507715	Splice_Region	rs753007469	A802A	0.08
UCEC	chr16	1510044	3'UTR	novel		0.33
UCEC	chr16	1510088	3'UTR	novel		0.43
UCEC	chr16	1501688	Nonsense_Mutation	NA	E463*	0.3
UCEC	chr16	1497458	Silent	rs150053866	P260P	0.6
UCEC	chr16	1507366	Missense_Mutation	rs116500468	D763N	0.25
UCEC	chr16	1502986	Missense_Mutation	NA	R609H	0.49
UCEC	chr16	1494358	Missense_Mutation	NA	G26D	0.37
UCEC	chr16	1497095	Missense_Mutation	rs371686195	G225R	0.48
UCEC	chr16	1502076	Missense_Mutation	rs377430333	S501L	0.45
UCEC	chr16	1494299	Frame_Shift_Ins	novel	*E7Rfs30**	0.35
UCEC	chr16	1497456	Missense_Mutation	novel	P260S	0.37
UCEC	chr16	1501666	Silent	rs758049957	T455T	0.37
UCEC	chr16	1499248	Missense_Mutation	novel	R283K	0.33
UCEC	chr16	1507355	Missense_Mutation	rs767706839	R759H	0.33
UCEC	chr16	1495434	Missense_Mutation	rs535065684	R142W	0.51
UCEC	chr16	1495532	Missense_Mutation	novel	E174D	0.57
UCEC	chr16	1497053	Missense_Mutation	rs758024477	V211M	0.4
UCEC	chr16	1500428	Missense_Mutation	novel	K362E	0.3
UCEC	chr16	1507051	Splice_Region	novel	T742T	0.35
UCEC	chr16	1510142	3'UTR	novel		0.5
UCEC	chr16	1500599	Missense_Mutation	rs759864279	R394H	0.16
UCEC	chr16	1495570	Missense_Mutation	novel	L187P	0.49
UCEC	chr16	1495592	Silent	NA	R194R	0.19
UCEC	chr16	1495434	Missense_Mutation	rs535065684	R142W	0.36
UCEC	chr16	1495562	Silent	novel	Y184Y	0.06
UCEC	chr16	1502049	Missense_Mutation	novel	D492G	0.35
UCEC	chr16	1510106	3'UTR	novel		0.25
UCEC	chr16	1500598	Missense_Mutation	NA	R394C	0.3
UCS	chr16	1494438	Missense_Mutation	novel	E53K	0.54

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.5444	0.22898
CHOL	DEL	0.1111	0.23475
ESCA	DEL	0.2826	0.012791
LUAD	DEL	0.124	0.1886
UCS	DEL	0.5357	0.13407

Survival Analysis

Cancer	P-value	Q-value
STAD	0.00094	Kaplan-Meier Survival Analysis
SARC	0.049	Kaplan-Meier Survival Analysis
MESO	0.015	Kaplan-Meier Survival Analysis
ACC	0.0045	Kaplan-Meier Survival Analysis
HNSC	0.0042	Kaplan-Meier Survival Analysis
SKCM	0.0027	Kaplan-Meier Survival Analysis
PRAD	0.018	Kaplan-Meier Survival Analysis
KIRP	0.024	Kaplan-Meier Survival Analysis
PAAD	0.049	Kaplan-Meier Survival Analysis
PCPG	0.02	Kaplan-Meier Survival Analysis
BLCA	0.0026	Kaplan-Meier Survival Analysis
CESC	0.012	Kaplan-Meier Survival Analysis
LAML	0.0013	Kaplan-Meier Survival Analysis
DLBC	0.027	Kaplan-Meier Survival Analysis
LGG	0.0018	Kaplan-Meier Survival Analysis
UVM	0.011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100726 (Gene tree)
Gene ID: 9894
Gene Symbol: TELO2
Alias: KIAA0683|hCLK2|TEL2
Full Name: telomere maintenance 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 17,116 bases
Position: chr16:1,493,344-1,510,459
Accession: 29099
RBP type: non-canonical RBP
Summary: This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497339	TELO2-202	1667	-	ENSP00000456383	426 (aa)	-	H3BRS3
ENST00000262319	TELO2-201	3314	XM_011522773	ENSP00000262319	837 (aa)	XP_011521075	Q9Y4R8
ENST00000568240	TELO2-207	1327	-	-	- (aa)	-	-
ENST00000569744	TELO2-208	575	-	-	- (aa)	-	-
ENST00000567427	TELO2-206	634	-	-	- (aa)	-	-
ENST00000564507	TELO2-204	903	-	-	- (aa)	-	-
ENST00000563676	TELO2-203	555	-	-	- (aa)	-	-
ENST00000567423	TELO2-205	479	-	ENSP00000457461	160 (aa)	-	H3BU45

Gene Model

Click here to download ENSG00000100726's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03460	Fanconi anemia pathway	KEGG
hsa04150	mTOR signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100726	Platelet Function Tests	2.7134300E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100726's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100726	TELO2	100	75.060	ENSMUSG00000024170	Telo2	99	75.060	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000723	telomere maintenance	21873635.	IBA	Process
GO:0000784	nuclear chromosome, telomeric region	21873635.	IBA	Component
GO:0005515	protein binding	18160036.20371770.20801936.20810650.20864032.23263282.24036451.24656813.	IPI	Function
GO:0005634	nucleus	20864032.	IDA	Component
GO:0005737	cytoplasm	20864032.23263282.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0016020	membrane	-	IEA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0019901	protein kinase binding	20864032.	IPI	Function
GO:0031931	TORC1 complex	23263282.	IDA	Component
GO:0031932	TORC2 complex	23263282.	IDA	Component
GO:0032006	regulation of TOR signaling	23263282.	IMP	Process
GO:0034399	nuclear periphery	20864032.	IDA	Component
GO:0042162	telomeric DNA binding	21873635.	IBA	Function
GO:0044877	protein-containing complex binding	20864032.	IDA	Function
GO:0050821	protein stabilization	24036451.	IMP	Process
GO:0051879	Hsp90 protein binding	20864032.	IPI	Function
GO:0060090	molecular adaptor activity	-	IEA	Function
GO:0070209	ASTRA complex	21873635.	IBA	Component
GO:0071902	positive regulation of protein serine/threonine kinase activity	24036451.	IMP	Process
GO:1904263	positive regulation of TORC1 signaling	24036451.	IMP	Process
GO:1904515	positive regulation of TORC2 signaling	24036451.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.