EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27495250	MicroRNA-21 promotes proliferation, migration, and invasion of colorectal cancer, and tumor growth associated with down-regulation of sec23a expression.	BMC Cancer	2016 Aug 5	Li C	doi: 10.1186/s12885-016-2628-z.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr14	39095971	Missense_Mutation	novel	D50N	0.12
BLCA	chr14	39064926	Missense_Mutation	rs776413541	C432Y	0.32
BLCA	chr14	39033324	Missense_Mutation	novel	S738C	0.38
BLCA	chr14	39085845	Nonsense_Mutation	novel	R249*	0.28
BLCA	chr14	39096098	Silent	NA	F7F	0.09
BLCA	chr14	39075965	Missense_Mutation	NA	D319E	0.19
BLCA	chr14	39061838	Missense_Mutation	novel	A478T	0.34
BRCA	chr14	39032682	3'UTR	novel		0.24
BRCA	chr14	39048699	Missense_Mutation	NA	D564N	0.13
BRCA	chr14	39032399	3'UTR	novel		0.21
BRCA	chr14	39040803	Missense_Mutation	novel	D691N	0.06
BRCA	chr14	39076029	Missense_Mutation	NA	P298L	0.21
BRCA	chr14	39063392	Missense_Mutation	NA	C444S	0.11
CESC	chr14	39045234	Missense_Mutation	NA	Q610E	0.39
CESC	chr14	39092563	Missense_Mutation	NA	S115C	0.43
CESC	chr14	39061792	Missense_Mutation	rs572679988	R493H	0.34
CESC	chr14	39032177	3'UTR	novel		0.22
CESC	chr14	39061872	Splice_Site	novel	X467_splice	0.48
CESC	chr14	39095922	Missense_Mutation	rs756632254	C66Y	0.4
COAD	chr14	39040819	Silent	NA	L685L	0.33
COAD	chr14	39045252	Missense_Mutation	NA	R604C	0.42
COAD	chr14	39074415	Missense_Mutation	novel	G368E	0.06
COAD	chr14	39039092	Missense_Mutation	NA	R716H	0.28
COAD	chr14	39033149	3'UTR	novel		0.08
COAD	chr14	39040880	Missense_Mutation	NA	A665V	0.43
COAD	chr14	39033085	3'UTR	novel		0.43
COAD	chr14	39095920	Missense_Mutation	rs34039376	R67C	0.46
COAD	chr14	39033120	3'UTR	novel		0.3
COAD	chr14	39042873	Splice_Site	NA	X634_splice	0.22
COAD	chr14	39075968	Missense_Mutation	NA	K318N	0.33
COAD	chr14	39061837	In_Frame_Ins	novel	A478delinsGNT	0.05
COAD	chr14	39086965	Missense_Mutation	rs773794829	R216H	0.18
ESCA	chr14	39031926	3'UTR	novel		0.19
ESCA	chr14	39063354	Silent	novel	T456T	0.27
ESCA	chr14	39032060	3'UTR	novel		0.38
ESCA	chr14	39085796	Frame_Shift_Ins	novel	*G265Efs41**	0.16
ESCA	chr14	39085798	Frame_Shift_Del	novel	*S263Gfs6**	0.17
ESCA	chr14	39033328	Nonsense_Mutation	novel	E737*	0.1
ESCA	chr14	39032683	3'UTR	novel		0.3
GBM	chr14	39033246	Missense_Mutation	novel	A764D	0.18
GBM	chr14	39045295	Missense_Mutation	novel	F589L	0.43
GBM	chr14	39055172	Missense_Mutation	novel	R544G	0.04
GBM	chr14	39067209	Missense_Mutation	novel	Q397H	0.09
HNSC	chr14	39061792	Missense_Mutation	rs572679988	R493H	0.16
HNSC	chr14	39040751	Missense_Mutation	novel	T708I	0.47
HNSC	chr14	39076068	Missense_Mutation	rs768946218	R285H	0.11
HNSC	chr14	39039080	Nonsense_Mutation	novel	S720*	0.07
HNSC	chr14	39067241	Missense_Mutation	novel	Q387E	0.36
HNSC	chr14	39095966	Silent	novel	L51L	0.23
HNSC	chr14	39085791	Missense_Mutation	NA	A267T	0.5
KIRC	chr14	39033263	Frame_Shift_Del	novel	*K758Nfs22**	0.21
KIRC	chr14	39042795	Nonsense_Mutation	NA	Y659*	0.32
KIRP	chr14	39045322	Frame_Shift_Del	novel	*F580Lfs5**	0.35
KIRP	chr14	39055174	Missense_Mutation	NA	L543H	0.28
LAML	chr14	39055234	Missense_Mutation	novel	A523V	0.14
LAML	chr14	39042844	Missense_Mutation	novel	L643P	0.06
LAML	chr14	39085897	Silent	novel	Q231Q	0.05
LGG	chr14	39055180	Missense_Mutation	novel	D541G	0.1
LIHC	chr14	39091554	Missense_Mutation	NA	H176Y	0.43
LIHC	chr14	39055170	Missense_Mutation	NA	R544S	0.22
LIHC	chr14	39048683	Missense_Mutation	novel	R569K	0.35
LIHC	chr14	39032871	3'UTR	novel		0.67
LUAD	chr14	39039093	Missense_Mutation	novel	R716C	0.17
LUAD	chr14	39040805	Missense_Mutation	novel	D690V	0.23
LUAD	chr14	39040806	Missense_Mutation	novel	D690Y	0.23
LUAD	chr14	39055283	Missense_Mutation	novel	Q507E	0.17
LUAD	chr14	39074500	Missense_Mutation	NA	T340A	0.54
LUAD	chr14	39061810	Missense_Mutation	rs770112771	H487R	0.19
LUAD	chr14	39091709	Missense_Mutation	rs148560912	G124V	0.52
LUAD	chr14	39096010	Missense_Mutation	novel	P37S	0.4
LUAD	chr14	39086991	Silent	NA	S207S	0.32
LUSC	chr14	39096040	Missense_Mutation	novel	S27C	0.41
LUSC	chr14	39095917	Missense_Mutation	novel	A68T	0.19
LUSC	chr14	39064981	Missense_Mutation	novel	I414L	0.35
LUSC	chr14	39067269	Missense_Mutation	novel	F377L	0.08
LUSC	chr14	39091523	Missense_Mutation	novel	S186N	0.29
LUSC	chr14	39095980	Nonsense_Mutation	NA	E47*	0.08
LUSC	chr14	39063368	Missense_Mutation	novel	S452G	0.54
MESO	chr14	39085844	Missense_Mutation	novel	R249Q	0.33
OV	chr14	39092609	Missense_Mutation	novel	G100C	0.11
OV	chr14	39092547	Silent	NA	V120V	0.19
OV	chr14	39042862	Missense_Mutation	NA	L637P	0.59
OV	chr14	39067265	Missense_Mutation	NA	T379A	0.26
OV	chr14	39096104	Missense_Mutation	NA	L5F	0.33
PAAD	chr14	39040871	Missense_Mutation	NA	R668Q	0.25
PRAD	chr14	39067185	Silent	rs140246467	T405T	0.35
READ	chr14	39075987	Missense_Mutation	NA	S312L	0.3
READ	chr14	39040794	Nonsense_Mutation	novel	E694*	0.44
READ	chr14	39095897	Splice_Site	novel	X74_splice	0.41
READ	chr14	39055264	Missense_Mutation	NA	I513T	0.21
READ	chr14	39096066	Missense_Mutation	rs778291254	R18Q	0.37
SKCM	chr14	39033139	3'UTR	novel		0.3
SKCM	chr14	39033140	3'UTR	novel		0.3
SKCM	chr14	39055148	Nonsense_Mutation	rs368022154	R552*	0.39
SKCM	chr14	39096056	Nonsense_Mutation	novel	W21*	0.1
SKCM	chr14	39040821	Silent	NA	L685L	0.2
SKCM	chr14	39085810	Silent	NA	P260P	0.26
SKCM	chr14	39091620	Missense_Mutation	NA	S154P	0.22
SKCM	chr14	39033187	3'UTR	novel		0.3
SKCM	chr14	39093231	Nonsense_Mutation	NA	R79*	0.27
SKCM	chr14	39045182	Missense_Mutation	NA	S627F	0.45
SKCM	chr14	39074509	Nonsense_Mutation	NA	R337*	0.45
SKCM	chr14	39074449	Missense_Mutation	NA	L357F	0.2
SKCM	chr14	39039088	Silent	NA	F717F	0.29
SKCM	chr14	39033179	3'UTR	novel		0.5
SKCM	chr14	39048677	Missense_Mutation	NA	S571L	0.15
STAD	chr14	39096066	Missense_Mutation	rs778291254	R18Q	0.11
STAD	chr14	39039034	Frame_Shift_Del	novel	*Q736Rfs21**	0.15
STAD	chr14	39096117	Translation_Start_Site	novel	M1?	0.18
STAD	chr14	39063342	Silent	NA	Y460Y	0.35
STAD	chr14	39095990	Silent	NA	T43T	0.21
STAD	chr14	39045283	Frame_Shift_Del	novel	*F593Lfs20**	0.22
STAD	chr14	39040862	Missense_Mutation	NA	G671A	0.14
STAD	chr14	39086927	Splice_Site	NA	X228_splice	0.31
STAD	chr14	39095985	Missense_Mutation	NA	L45P	0.47
STAD	chr14	39086940	Silent	NA	P224P	0.32
STAD	chr14	39067188	Silent	novel	G404G	0.34
STAD	chr14	39040736	Missense_Mutation	NA	S713N	0.18
STAD	chr14	39048693	Missense_Mutation	NA	S566R	0.15
THCA	chr14	39045300	Frame_Shift_Ins	novel	*S588Vfs27**	0.12
THCA	chr14	39091639	Silent	NA	L147L	0.08
THCA	chr14	39096128	5'UTR	novel		0.05
THYM	chr14	39042835	Missense_Mutation	novel	R646P	0.44
UCEC	chr14	39033022	3'UTR	novel		0.25
UCEC	chr14	39074508	Missense_Mutation	NA	R337Q	0.32
UCEC	chr14	39096103	Missense_Mutation	NA	E6K	0.32
UCEC	chr14	39033319	Missense_Mutation	novel	A740T	0.3
UCEC	chr14	39042856	Missense_Mutation	novel	S639I	0.1
UCEC	chr14	39045311	Missense_Mutation	novel	L584S	0.41
UCEC	chr14	39091582	Silent	novel	L166L	0.29
UCEC	chr14	39032104	3'UTR	novel		0.08
UCEC	chr14	39033288	Missense_Mutation	novel	Q750R	0.54
UCEC	chr14	39055219	Missense_Mutation	rs754673747	R528Q	0.45
UCEC	chr14	39040737	Missense_Mutation	novel	S713G	0.44
UCEC	chr14	39033220	3'UTR	novel		0.12
UCEC	chr14	39076012	Missense_Mutation	novel	D304Y	0.17
UCEC	chr14	39045163	Missense_Mutation	novel	E633D	0.52
UCEC	chr14	39075945	Frame_Shift_Del	novel	*K326Rfs27**	0.31
UCEC	chr14	39096070	Missense_Mutation	novel	V17I	0.36
UCEC	chr14	39045305	Missense_Mutation	novel	R586I	0.21
UCEC	chr14	39091619	Nonsense_Mutation	NA	S154*	0.27
UCEC	chr14	39033201	3'UTR	novel		0.15
UCEC	chr14	39076068	Missense_Mutation	rs768946218	R285H	0.31
UCEC	chr14	39033128	3'UTR	novel		0.15
UCEC	chr14	39074467	Missense_Mutation	NA	A351T	0.26
UCEC	chr14	39096066	Missense_Mutation	rs778291254	R18Q	0.13
UCEC	chr14	39045187	Silent	rs751758051	A625A	0.21
UCEC	chr14	39067295	Missense_Mutation	NA	G369R	0.27
UCEC	chr14	39074471	Silent	rs143126019	A349A	0.37
UCEC	chr14	39085844	Missense_Mutation	novel	R249Q	0.39
UCEC	chr14	39085881	Missense_Mutation	novel	D237Y	0.33
UCEC	chr14	39032625	3'UTR	novel		0.4
UCEC	chr14	39042835	Missense_Mutation	NA	R646H	0.4
UCEC	chr14	39076068	Missense_Mutation	rs768946218	R285H	0.44
UCEC	chr14	39032841	3'UTR	novel		0.48
UCEC	chr14	39033300	Missense_Mutation	novel	D746G	0.39
UCEC	chr14	39032634	3'UTR	novel		0.27
UCEC	chr14	39055155	Silent	novel	Q549Q	0.37
UCEC	chr14	39055255	Missense_Mutation	novel	S516Y	0.36
UCEC	chr14	39040843	Missense_Mutation	novel	E677D	0.38
UCEC	chr14	39039046	Missense_Mutation	novel	M731I	0.37
UCEC	chr14	39085785	Missense_Mutation	novel	S269P	0.3
UCEC	chr14	39032246	3'UTR	novel		0.48
UCEC	chr14	39033212	3'UTR	rs752336930		0.17
UCEC	chr14	39091624	Missense_Mutation	novel	Q152H	0.27
UCEC	chr14	39032191	3'UTR	novel		0.38
UCEC	chr14	39033046	3'UTR	novel		0.54
UCEC	chr14	39045187	Silent	rs751758051	A625A	0.43
UCEC	chr14	39033212	3'UTR	novel		0.35
UCEC	chr14	39064933	Nonsense_Mutation	novel	G430*	0.4
UCEC	chr14	39086929	Missense_Mutation	novel	R228I	0.31
UCEC	chr14	39096009	Missense_Mutation	novel	P37H	0.26
UCEC	chr14	39032632	3'UTR	novel		0.5
UCEC	chr14	39039092	Missense_Mutation	NA	R716H	0.12
UCEC	chr14	39032625	3'UTR	novel		0.36
UCEC	chr14	39091500	Missense_Mutation	novel	D194Y	0.08
UCEC	chr14	39040742	Missense_Mutation	novel	G711E	0.23
UCEC	chr14	39061795	Missense_Mutation	novel	R492I	0.23
UCEC	chr14	39075966	Missense_Mutation	novel	D319G	0.23
UCEC	chr14	39064977	Missense_Mutation	novel	K415T	0.43
UCEC	chr14	39032289	3'UTR	novel		0.27
UCEC	chr14	39042835	Missense_Mutation	NA	R646H	0.25
UCEC	chr14	39085805	Missense_Mutation	rs763784277	R262H	0.25
UCEC	chr14	39061840	Missense_Mutation	novel	G477D	0.52
UCEC	chr14	39033297	Missense_Mutation	novel	V747A	0.19
UCS	chr14	39086957	Nonsense_Mutation	novel	Q219*	0.74

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1444	0.19769
CHOL	DEL	0.3611	0.00040262
KIRP	DEL	0.1632	0.085174
PAAD	DEL	0.0598	0.11332

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.026	Kaplan-Meier Survival Analysis
STAD	0.00059	Kaplan-Meier Survival Analysis
SARC	0.011	Kaplan-Meier Survival Analysis
MESO	0.0067	Kaplan-Meier Survival Analysis
ACC	0.0028	Kaplan-Meier Survival Analysis
SKCM	0.0026	Kaplan-Meier Survival Analysis
KIRP	0.0016	Kaplan-Meier Survival Analysis
COAD	0.014	Kaplan-Meier Survival Analysis
PAAD	0.038	Kaplan-Meier Survival Analysis
BLCA	0.0011	Kaplan-Meier Survival Analysis
CESC	0.00084	Kaplan-Meier Survival Analysis
LUAD	0.019	Kaplan-Meier Survival Analysis
UVM	0.0035	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100934 (Gene tree)
Gene ID: 10484
Gene Symbol: SEC23A
Alias: N
Full Name: Sec23 homolog A, coat complex II component
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 77,728 bases
Position: chr14:39,031,919-39,109,646
Accession: 10701
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000555363	SEC23A-209	704	-	-	- (aa)	-	-
ENST00000557280	SEC23A-213	561	-	ENSP00000452575	85 (aa)	-	G3V5X8
ENST00000553970	SEC23A-206	574	-	ENSP00000451924	86 (aa)	-	G3V4Q2
ENST00000537403	SEC23A-202	4215	-	ENSP00000444193	563 (aa)	-	Q15436
ENST00000545328	SEC23A-203	2734	-	ENSP00000445393	736 (aa)	-	F5H365
ENST00000625395	SEC23A-215	261	-	ENSP00000486142	86 (aa)	-	G3V4Q2
ENST00000556092	SEC23A-212	571	-	ENSP00000451230	140 (aa)	-	G3V3G5
ENST00000557437	SEC23A-214	575	-	ENSP00000452390	40 (aa)	-	G3V5K1
ENST00000548032	SEC23A-204	907	-	ENSP00000447489	108 (aa)	-	G3V1W4
ENST00000555017	SEC23A-208	588	-	ENSP00000450819	169 (aa)	-	G3V2R6
ENST00000555682	SEC23A-211	398	-	-	- (aa)	-	-
ENST00000555425	SEC23A-210	547	-	ENSP00000451999	93 (aa)	-	G3V4V1
ENST00000307712	SEC23A-201	4135	XM_005267262	ENSP00000306881	765 (aa)	XP_005267319	Q15436
ENST00000554615	SEC23A-207	3813	-	-	- (aa)	-	-
ENST00000553925	SEC23A-205	484	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100934's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100934	Taste Perception	1.8140000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100934	rs8018720	14	39086981	C	Vitamin D levels	29343764	[0.014-0.024] unit decrease	0.019	EFO_0004631

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100934's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100934	SEC23A	99	81.522	FBgn0262125	Sec23	99	74.065	Drosophila_melanogaster
ENSG00000100934	SEC23A	100	92.500	ENSG00000101310	SEC23B	100	96.875	Homo_sapiens
ENSG00000100934	SEC23A	99	49.677	YPR181C		99	49.677	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	-	TAS	Process
GO:0005096	GTPase activator activity	21873635.	IBA	Function
GO:0005515	protein binding	10075675.16091426.17499046.18692470.20946353.27018634.27551091.28442536.	IPI	Function
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	8898360.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	-	IEA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0008270	zinc ion binding	18843296.	IDA	Function
GO:0012507	ER to Golgi transport vesicle membrane	8898360.	IGI	Component
GO:0012507	ER to Golgi transport vesicle membrane	-	TAS	Component
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0019898	extrinsic component of membrane	8898360.	IDA	Component
GO:0030127	COPII vesicle coat	21873635.	IBA	Component
GO:0030127	COPII vesicle coat	17499046.	IDA	Component
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0048208	COPII vesicle coating	-	TAS	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0070971	endoplasmic reticulum exit site	21873635.	IBA	Component
GO:0070971	endoplasmic reticulum exit site	8898360.28442536.	IDA	Component
GO:0072659	protein localization to plasma membrane	-	IEA	Process
GO:0090110	cargo loading into COPII-coated vesicle	21873635.	IBA	Process
GO:0090110	cargo loading into COPII-coated vesicle	17499046.18843296.	IDA	Process
GO:0090110	cargo loading into COPII-coated vesicle	8898360.	IGI	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.