EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18713839	S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.	Carcinogenesis	2008 Nov	Leal JF	doi: 10.1093/carcin/bgn198
28533090	Identification of AHCY inhibitors using novel high-throughput mass spectrometry.	Biochem Biophys Res Commun	2017 Sep 9	Uchiyama N	doi: 10.1016/j.bbrc.2017.05.107

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr20	34295375	Intron	novel		0.22
BLCA	chr20	34292431	Silent	novel	P124P	0.15
BLCA	chr20	34294021	Intron	novel		0.63
BRCA	chr20	34292481	Missense_Mutation	NA	E108Q	0.47
BRCA	chr20	34281053	Missense_Mutation	rs377090568	P427L	0.13
BRCA	chr20	34294015	Intron	novel		0.15
BRCA	chr20	34290386	Silent	rs146829385	I306I	0.14
BRCA	chr20	34294133	Missense_Mutation	NA	I81M	0.28
BRCA	chr20	34290586	Silent	rs762639667	V273V	0.4
BRCA	chr20	34285439	Splice_Site	NA	X389_splice	0.21
BRCA	chr20	34303329	5'UTR	novel		0.17
CESC	chr20	34290921	Silent	novel	L192L	0.46
CESC	chr20	34285580	Missense_Mutation	rs767274069	R343W	0.38
CESC	chr20	34295434	Silent	novel	T60T	0.33
CESC	chr20	34292395	Silent	NA	T136T	0.28
CESC	chr20	34291476	Missense_Mutation	novel	M167I	0.13
COAD	chr20	34290775	Missense_Mutation	NA	I241T	0.38
COAD	chr20	34290861	Silent	rs141172613	A212A	0.36
COAD	chr20	34285513	Missense_Mutation	NA	Q365R	0.48
COAD	chr20	34290782	Missense_Mutation	rs375760628	V239I	0.16
COAD	chr20	34295468	Missense_Mutation	rs563484762	R49H	0.24
COAD	chr20	34285496	Missense_Mutation	NA	E371K	0.18
COAD	chr20	34281021	3'UTR	rs370100132		0.08
COAD	chr20	34293898	Intron	novel		0.21
COAD	chr20	34295461	Silent	NA	A51A	0.52
COAD	chr20	34292452	Silent	NA	T117T	0.28
COAD	chr20	34290603	Missense_Mutation	novel	E268Q	0.49
COAD	chr20	34295508	Missense_Mutation	NA	R36W	0.19
COAD	chr20	34295412	Missense_Mutation	rs199533546	V68I	0.15
ESCA	chr20	34281053	Missense_Mutation	rs377090568	P427L	0.18
GBM	chr20	34285579	Missense_Mutation	novel	R343Q	0.43
GBM	chr20	34290742	Missense_Mutation	novel	A252V	0.22
GBM	chr20	34285566	Silent	NA	L347L	0.42
HNSC	chr20	34292398	Silent	rs199616559	L135L	0.12
HNSC	chr20	34291514	Missense_Mutation	novel	E155K	0.25
KIRP	chr20	34285531	Missense_Mutation	NA	S359N	0.18
KIRP	chr20	34281088	In_Frame_Del	novel	L409_Q415del	0.3
KIRP	chr20	34290875	Missense_Mutation	NA	D208N	0.37
LGG	chr20	34285599	Silent	rs139344907	I336I	0.06
LIHC	chr20	34303280	5'UTR	novel		0.31
LUAD	chr20	34294099	Missense_Mutation	novel	A93S	0.27
LUAD	chr20	34290335	Silent	rs746288986	P323P	0.38
LUAD	chr20	34291503	Silent	NA	T158T	0.49
LUAD	chr20	34290758	Missense_Mutation	rs371055374	I247V	0.23
LUAD	chr20	34285566	Silent	NA	L347L	0.23
LUAD	chr20	34290756	Silent	NA	I247I	0.26
LUSC	chr20	34285586	Missense_Mutation	rs765418686	E341K	0.4
OV	chr20	34295354	Intron	novel		0.45
PAAD	chr20	34291427	Missense_Mutation	novel	V184I	0.16
PAAD	chr20	34295520	Missense_Mutation	novel	L32M	0.19
PRAD	chr20	34290737	Missense_Mutation	NA	M254V	0.45
PRAD	chr20	34285621	Missense_Mutation	rs116262714	R329Q	0.31
READ	chr20	34281071	Missense_Mutation	NA	C421Y	0.15
READ	chr20	34303294	5'UTR	novel		0.56
SARC	chr20	34280858	3'UTR	novel		0.19
SKCM	chr20	34293996	Intron	novel		0.62
SKCM	chr20	34295270	Intron	novel		0.31
SKCM	chr20	34295271	Intron	novel		0.25
SKCM	chr20	34291429	Missense_Mutation	NA	S183F	0.31
SKCM	chr20	34290803	Silent	novel	L232L	0.39
SKCM	chr20	34295525	Missense_Mutation	NA	P30L	0.33
SKCM	chr20	34285462	Missense_Mutation	novel	G382E	0.14
SKCM	chr20	34285457	Missense_Mutation	NA	H384Y	0.15
SKCM	chr20	34291484	Missense_Mutation	novel	Y165H	0.05
SKCM	chr20	34281013	3'UTR	novel		0.53
SKCM	chr20	34291526	Nonsense_Mutation	rs772336831	R151*	0.4
SKCM	chr20	34291527	Silent	novel	I150I	0.4
SKCM	chr20	34285452	Silent	novel	F385F	0.31
SKCM	chr20	34291429	Missense_Mutation	NA	S183F	0.39
STAD	chr20	34290771	Silent	rs200322249	T242T	0.14
STAD	chr20	34295506	Silent	NA	R36R	0.14
STAD	chr20	34290810	Silent	NA	A229A	0.05
STAD	chr20	34292437	Silent	rs141935523	D122D	0.41
STAD	chr20	34295412	Missense_Mutation	rs199533546	V68I	0.26
STAD	chr20	34281160	Silent	novel	D391D	0.43
STAD	chr20	34285603	Missense_Mutation	NA	R335H	0.11
STAD	chr20	34292491	Silent	rs753399141	G104G	0.43
STAD	chr20	34280980	3'UTR	NA		0.23
STAD	chr20	34292490	Missense_Mutation	NA	E105K	0.17
STAD	chr20	34295480	Missense_Mutation	NA	L45R	0.14
UCEC	chr20	34295513	Missense_Mutation	rs775953872	R34H	0.44
UCEC	chr20	34280825	3'UTR	novel		0.5
UCEC	chr20	34295412	Missense_Mutation	rs199533546	V68I	0.37
UCEC	chr20	34281055	Missense_Mutation	NA	K426N	0.18
UCEC	chr20	34290884	Missense_Mutation	rs749200122	R205W	0.41
UCEC	chr20	34290335	Silent	rs746288986	P323P	0.14
UCEC	chr20	34295578	Silent	rs78150651	I12I	0.23
UCEC	chr20	34280960	3'UTR	novel		0.14
UCEC	chr20	34285589	Missense_Mutation	novel	A340T	0.23
UCEC	chr20	34290933	Silent	novel	K188K	0.46
UCEC	chr20	34292490	Missense_Mutation	NA	E105K	0.14
UCEC	chr20	34280937	3'UTR	novel		0.4
UCEC	chr20	34292371	Silent	novel	P144P	0.42
UCEC	chr20	34295412	Missense_Mutation	rs199533546	V68I	0.35
UCEC	chr20	34303245	Missense_Mutation	novel	V9A	0.44
UCEC	chr20	34294055	Intron	novel		0.42
UCEC	chr20	34285521	Silent	novel	F362F	0.22
UCEC	chr20	34292403	Missense_Mutation	novel	D134N	0.33
UCEC	chr20	34290803	Missense_Mutation	novel	L232M	0.36
UCEC	chr20	34295400	Missense_Mutation	NA	A72T	0.55
UCEC	chr20	34294109	Silent	NA	A89A	0.12
UCEC	chr20	34290752	Missense_Mutation	NA	A249T	0.22
UCEC	chr20	34290784	Missense_Mutation	rs745825646	R238H	0.27
UCEC	chr20	34290790	Frame_Shift_Ins	novel	*G236Efs25**	0.05
UCEC	chr20	34290791	Frame_Shift_Ins	novel	*G236Rfs13**	0.05
UCEC	chr20	34292402	Missense_Mutation	novel	D134G	0.48
UCEC	chr20	34295282	Intron	novel		0.29
UCEC	chr20	34280931	3'UTR	novel		0.38
UCEC	chr20	34295513	Missense_Mutation	rs775953872	R34H	0.33
UCEC	chr20	34281033	3'UTR	novel		0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
HNSC	AMP	0.3257	5.7791e-06
LAML	DEL	0.0157	0.14746
READ	AMP	0.8667	1.9519e-21

Survival Analysis

Cancer	P-value	Q-value
THYM	0.04	Kaplan-Meier Survival Analysis
KIRC	0.028	Kaplan-Meier Survival Analysis
SARC	0.00025	Kaplan-Meier Survival Analysis
ACC	0.0084	Kaplan-Meier Survival Analysis
SKCM	0.0057	Kaplan-Meier Survival Analysis
ESCA	0.041	Kaplan-Meier Survival Analysis
KIRP	0.013	Kaplan-Meier Survival Analysis
BLCA	0.0041	Kaplan-Meier Survival Analysis
LAML	0.043	Kaplan-Meier Survival Analysis
UCEC	0.0072	Kaplan-Meier Survival Analysis
LIHC	0.0015	Kaplan-Meier Survival Analysis
DLBC	0.032	Kaplan-Meier Survival Analysis
LGG	0.015	Kaplan-Meier Survival Analysis
LUAD	0.046	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000101444 (Gene tree)
Gene ID: 191
Gene Symbol: AHCY
Alias: SAHH
Full Name: adenosylhomocysteinase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 77,137 bases
Position: chr20:34,234,840-34,311,976
Accession: 343
RBP type: non-canonical RBP
Summary: S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19413897	Proteome analysis of Norway maple (Acer platanoides L.) seeds dormancy breaking and germination: influence of abscisic and gibberellic acids.	BMC Plant Biol	2009 May 4	Pawlowski TA	doi: 10.1186/1471-2229-9-48.
17805460	Hyperhomocysteinemia-mediated DNA hypomethylation and its potential epigenetic role in rats.	Acta Biochim Biophys Sin (Shanghai)	2007 Sep	Jiang Y	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000473516	AHCY-203	488	-	-	- (aa)	-	-
ENST00000480653	AHCY-204	2211	-	-	- (aa)	-	-
ENST00000468908	AHCY-202	675	-	-	- (aa)	-	-
ENST00000217426	AHCY-201	2143	XM_017027708	ENSP00000217426	432 (aa)	XP_016883197	P23526
ENST00000606061	AHCY-206	1170	-	-	- (aa)	-	-
ENST00000538132	AHCY-205	2366	XM_005260317	ENSP00000442820	404 (aa)	XP_005260374	P23526

Gene Model

Click here to download ENSG00000101444's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00270	Cysteine and methionine metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101444's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101444	AHCY	100	77.696	WBGene00019322	ahcy-1	99	76.905	Caenorhabditis_elegans
ENSG00000101444	AHCY	100	50.864	ENSMUSG00000029772	Ahcyl2	100	53.043	Mus_musculus
ENSG00000101444	AHCY	100	71.429	YER043C		98	71.041	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000096	sulfur amino acid metabolic process	-	TAS	Process
GO:0001666	response to hypoxia	-	IEA	Process
GO:0002439	chronic inflammatory response to antigenic stimulus	-	IEA	Process
GO:0004013	adenosylhomocysteinase activity	21873635.	IBA	Function
GO:0004013	adenosylhomocysteinase activity	2596825.	TAS	Function
GO:0005515	protein binding	25416956.25910212.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006730	one-carbon metabolic process	-	IEA	Process
GO:0007584	response to nutrient	-	IEA	Process
GO:0019510	S-adenosylhomocysteine catabolic process	-	IEA	Process
GO:0030554	adenyl nucleotide binding	-	IEA	Function
GO:0032259	methylation	-	TAS	Process
GO:0033353	S-adenosylmethionine cycle	21873635.	IBA	Process
GO:0042470	melanosome	-	IEA	Component
GO:0042745	circadian sleep/wake cycle	-	IEA	Process
GO:0042802	identical protein binding	-	IEA	Function
GO:0043005	neuron projection	-	IEA	Component
GO:0051287	NAD binding	-	IEA	Function
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.