EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26938858	Function of Deubiquitinating Enzyme USP14 as Oncogene in Different Types of Cancer.	Cell Physiol Biochem	2016	Zhu Y	doi: 10.1159/000443051
16465409	Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases.	Oncol Rep	2006 Mar	Shinji S	-
17553343	[Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues].	Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi	2007 Jun	Yang Y	-
25429837	Ubiquitin-specific protease 14 (USP14) regulates cellular proliferation and apoptosis in epithelial ovarian cancer.	Med Oncol	2015 Jan	Wang Y	doi: 10.1007/s12032-014-0379-8
26712154	Downregulation of ubiquitin-specific protease 14 (USP14) inhibits breast cancer cell proliferation and metastasis, but promotes apoptosis.	J Mol Histol	2016 Feb	Zhu L	doi: 10.1007/s10735-015-9650-3
28151478	Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor.	Cell Death Dis	2017 Feb 2	Liao Y	doi: 10.1038/cddis.2016.477.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr18	211255	Missense_Mutation	rs763757165	E486K	0.3
BLCA	chr18	209994	Silent	novel	Q396Q	0.31
BLCA	chr18	163451	Nonsense_Mutation	novel	K54*	0.13
BLCA	chr18	179002	Missense_Mutation	rs141269921	V89I	0.51
BLCA	chr18	178985	Missense_Mutation	novel	S83L	0.31
BLCA	chr18	179008	Missense_Mutation	novel	D91Y	0.17
BRCA	chr18	211389	3'UTR	novel		0.6
BRCA	chr18	213498	3'UTR	novel		0.17
BRCA	chr18	210024	Silent	rs772506851	F406F	0.33
BRCA	chr18	178978	Nonsense_Mutation	NA	E81*	0.2
BRCA	chr18	211283	In_Frame_Ins	novel		0.1
CESC	chr18	213584	3'UTR	novel		0.43
CESC	chr18	198112	Silent	rs189562044	F247F	0.25
CESC	chr18	198131	Missense_Mutation	rs374300842	T254A	0.12
COAD	chr18	198113	Missense_Mutation	NA	G248S	0.19
COAD	chr18	203145	Frame_Shift_Ins	NA	*Y333Lfs2**	0.33
COAD	chr18	196734	Silent	rs374980775	A187A	0.19
COAD	chr18	163331	Missense_Mutation	NA	K14Q	0.11
COAD	chr18	199221	In_Frame_Del	rs758112641	E264del	0.23
COAD	chr18	179023	Nonsense_Mutation	novel	*Q96Hfs3**	0.06
COAD	chr18	179025	Missense_Mutation	novel	Q96H	0.02
ESCA	chr18	211238	Missense_Mutation	novel	Y480C	0.16
ESCA	chr18	203180	Missense_Mutation	novel	K342R	0.5
GBM	chr18	199242	Nonsense_Mutation	novel	G268*	0.34
GBM	chr18	202881	Missense_Mutation	novel	R293Q	0.19
GBM	chr18	180305	Missense_Mutation	novel	R124C	0.18
KICH	chr18	211193	Missense_Mutation	novel	R465L	0.44
KIRP	chr18	211361	3'UTR	novel		0.33
KIRP	chr18	163336	Missense_Mutation	NA	F15L	0.7
KIRP	chr18	192871	Frame_Shift_Del	novel	*M146Wfs62**	0.44
LGG	chr18	202880	Nonsense_Mutation	NA	R293*	0.17
LGG	chr18	197620	Missense_Mutation	novel	A200V	0.24
LUAD	chr18	210491	Missense_Mutation	novel	Q444L	0.15
LUAD	chr18	197634	Missense_Mutation	NA	I205L	0.18
LUAD	chr18	196747	Missense_Mutation	NA	Q192K	0.13
LUAD	chr18	178978	Missense_Mutation	NA	E81K	0.15
LUAD	chr18	202918	Missense_Mutation	novel	L305F	0.24
LUAD	chr18	180238	Missense_Mutation	NA	M101I	0.7
LUSC	chr18	192857	Silent	novel	L140L	0.63
OV	chr18	198094	Missense_Mutation	NA	S241R	0.35
OV	chr18	192876	Missense_Mutation	novel	A147T	0.05
OV	chr18	211269	Missense_Mutation	NA	E490D	0.28
OV	chr18	198062	Missense_Mutation	novel	A231T	0.05
OV	chr18	211231	Missense_Mutation	novel	L478V	0.55
PAAD	chr18	163369	Silent	novel	P26P	0.21
PAAD	chr18	197615	Splice_Site	novel	X199_splice	0.15
PRAD	chr18	163395	Missense_Mutation	rs201080569	A35V	0.6
PRAD	chr18	179030	Missense_Mutation	novel	A98V	0.48
PRAD	chr18	192883	Missense_Mutation	rs577282582	A149V	0.39
PRAD	chr18	198100	Silent	novel	I243I	0.33
READ	chr18	211517	3'UTR	novel		0.31
SARC	chr18	211617	3'UTR	novel		0.14
SKCM	chr18	163367	Missense_Mutation	rs201975297	P26S	0.54
SKCM	chr18	203129	Missense_Mutation	novel	T325I	0.39
SKCM	chr18	203147	Missense_Mutation	novel	F331Y	0.4
SKCM	chr18	180332	Missense_Mutation	novel	L133F	0.29
SKCM	chr18	180333	Missense_Mutation	novel	L133P	0.29
STAD	chr18	166813	Frame_Shift_Del	novel	*N65Mfs3**	0.29
STAD	chr18	211247	Missense_Mutation	rs757981348	R483H	0.19
STAD	chr18	196666	Missense_Mutation	novel	K165E	0.08
STAD	chr18	196733	Missense_Mutation	NA	A187V	0.23
STAD	chr18	211172	Missense_Mutation	NA	V458A	0.5
STAD	chr18	196658	Missense_Mutation	novel	S162F	0.33
STAD	chr18	209989	Frame_Shift_Del	novel	*Q396Rfs29**	0.12
STAD	chr18	211160	Missense_Mutation	NA	K454T	0.29
STAD	chr18	203146	Frame_Shift_Del	novel	*Y333Ifs7**	0.29
STAD	chr18	203145	Frame_Shift_Ins	NA	*Y333Lfs2**	0.23
UCEC	chr18	203144	Missense_Mutation	NA	R330Q	0.28
UCEC	chr18	202881	Missense_Mutation	novel	R293Q	0.05
UCEC	chr18	158536	5'Flank	novel		0.29
UCEC	chr18	166795	Missense_Mutation	NA	D57E	0.28
UCEC	chr18	203173	Missense_Mutation	NA	N340H	0.5
UCEC	chr18	204645	Missense_Mutation	NA	K373Q	0.48
UCEC	chr18	204640	Missense_Mutation	novel	R371Q	0.63
UCEC	chr18	163330	Missense_Mutation	rs370161815	E13D	0.39
UCEC	chr18	202912	Silent	novel	P303P	0.32
UCEC	chr18	211531	3'UTR	novel		0.57
UCEC	chr18	214529	3'UTR	novel		0.75
UCEC	chr18	210009	Silent	NA	Y401Y	0.06
UCEC	chr18	214622	3'UTR	novel		0.46
UCEC	chr18	211462	3'UTR	novel		0.29
UCEC	chr18	211183	Missense_Mutation	novel	D462Y	0.16
UCEC	chr18	178938	Missense_Mutation	NA	M67I	0.43
UCEC	chr18	163346	Missense_Mutation	novel	E19K	0.42
UCEC	chr18	197642	Missense_Mutation	novel	M207I	0.3
UCEC	chr18	199215	Nonsense_Mutation	novel	E259*	0.37
UCEC	chr18	211806	3'UTR	novel		0.37
UCEC	chr18	204623	Missense_Mutation	rs750713987	E365D	0.07
UCEC	chr18	163432	Missense_Mutation	novel	M47I	0.32
UCEC	chr18	199211	Silent	novel	C257C	0.35
UCEC	chr18	204669	Nonsense_Mutation	novel	K381*	0.67
UCEC	chr18	213654	3'UTR	novel		0.41
UCEC	chr18	199213	Frame_Shift_Del	novel	*T258Kfs67**	0.27
UCEC	chr18	213456	3'UTR	novel		0.38
UCEC	chr18	214613	3'UTR	novel		0.3
UCEC	chr18	196635	Splice_Site	novel	X155_splice	0.17
UCEC	chr18	211815	3'UTR	novel		0.22
UCEC	chr18	213654	3'UTR	novel		0.17
UCEC	chr18	214583	3'UTR	novel		0.19
UCEC	chr18	197624	Silent	novel	N201N	0.61
UCEC	chr18	213553	3'UTR	novel		0.45
UCEC	chr18	211222	Missense_Mutation	rs773654673	A475T	0.28
UCEC	chr18	211871	3'UTR	novel		0.45
UCEC	chr18	213522	3'UTR	novel		0.47
UCEC	chr18	211839	3'UTR	novel		0.48
UCEC	chr18	211648	3'UTR	novel		0.49
UCEC	chr18	203111	Missense_Mutation	novel	R319Q	0.12
UCEC	chr18	204640	Missense_Mutation	novel	R371Q	0.12
UCEC	chr18	211727	3'UTR	novel		0.29
UCEC	chr18	211171	Missense_Mutation	novel	V458I	0.07
UCEC	chr18	163365	Missense_Mutation	novel	P25H	0.33
UCEC	chr18	203144	Missense_Mutation	NA	R330Q	0.37
UCEC	chr18	180243	Missense_Mutation	novel	L103S	0.42
UCEC	chr18	214587	3'UTR	novel		0.31
UCEC	chr18	203147	Missense_Mutation	NA	F331C	0.28
UCEC	chr18	211362	3'UTR	novel		0.27
UCEC	chr18	180306	Missense_Mutation	rs749757792	R124H	0.53
UCEC	chr18	211296	3'UTR	novel		0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LUSC	AMP	0.2695	0.19322
PAAD	DEL	0.1413	0.12313
SARC	DEL	0.2179	0.24876
TGCT	DEL	0.6867	0.00046313

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.036	Kaplan-Meier Survival Analysis
SARC	0.0039	Kaplan-Meier Survival Analysis
MESO	0.012	Kaplan-Meier Survival Analysis
ACC	0.0013	Kaplan-Meier Survival Analysis
HNSC	0.00024	Kaplan-Meier Survival Analysis
CESC	0.035	Kaplan-Meier Survival Analysis
UCEC	0.0051	Kaplan-Meier Survival Analysis
LIHC	0.00028	Kaplan-Meier Survival Analysis
LGG	0.011	Kaplan-Meier Survival Analysis
LUAD	0.0026	Kaplan-Meier Survival Analysis
UVM	0.049	Kaplan-Meier Survival Analysis
OV	0.0011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000101557 (Gene tree)
Gene ID: 9097
Gene Symbol: USP14
Alias: TGT
Full Name: ubiquitin specific peptidase 14
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 56,247 bases
Position: chr18:158,383-214,629
Accession: 12612
RBP type: non-canonical RBP
Summary: This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000578786	USP14-204	1104	-	-	- (aa)	-	-
ENST00000580410	USP14-206	474	-	ENSP00000463891	20 (aa)	-	J3QQT6
ENST00000581983	USP14-207	503	-	ENSP00000462315	28 (aa)	-	J3KS55
ENST00000582707	USP14-208	1803	-	ENSP00000464447	459 (aa)	-	P54578
ENST00000261601	USP14-201	4921	-	ENSP00000261601	494 (aa)	-	P54578
ENST00000583119	USP14-209	578	-	ENSP00000473563	33 (aa)	-	R4GNB0
ENST00000400266	USP14-203	1681	-	ENSP00000383125	483 (aa)	-	P54578
ENST00000578942	USP14-205	3189	-	-	- (aa)	-	-
ENST00000383589	USP14-202	2168	-	ENSP00000373083	448 (aa)	-	A6NJA2

Gene Model

Click here to download ENSG00000101557's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101557's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000101557	USP14	100	85.000	WBGene00006856	usp-14	94	41.551	Caenorhabditis_elegans
ENSG00000101557	USP14	100	100.000	ENSMUSG00000047879	Usp14	100	96.950	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000502	proteasome complex	-	IEA	Component
GO:0004197	cysteine-type endopeptidase activity	9827704.	TAS	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	23958854.	IDA	Function
GO:0004866	endopeptidase inhibitor activity	18162577.	IMP	Function
GO:0005515	protein binding	19106094.19135427.19896943.	IPI	Function
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006511	ubiquitin-dependent protein catabolic process	-	IEA	Process
GO:0007268	chemical synaptic transmission	-	IEA	Process
GO:0008193	tRNA guanylyltransferase activity	8579355.	TAS	Function
GO:0009986	cell surface	19106094.	IDA	Component
GO:0010951	negative regulation of endopeptidase activity	-	IEA	Process
GO:0016579	protein deubiquitination	23958854.	IDA	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0031410	cytoplasmic vesicle	19106094.	IDA	Component
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	19106094.	IDA	Function
GO:0045087	innate immune response	-	IEA	Process
GO:0045202	synapse	-	IEA	Component
GO:0050920	regulation of chemotaxis	19106094.	IMP	Process
GO:0061136	regulation of proteasomal protein catabolic process	18162577.	IMP	Process
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:0070628	proteasome binding	18162577.	IDA	Function
GO:0099116	tRNA 5'-end processing	-	IEA	Process
GO:1903070	negative regulation of ER-associated ubiquitin-dependent protein catabolic process	19135427.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.