EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28627627	Stromal antigen 2 functions as a tumor suppressor in bladder cancer cells.	Oncol Rep	2017 Aug	Wang H	doi: 10.3892/or.2017.5711
24121791	Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy.	Nat Genet	2013 Dec	Balb??s-Mart??nez C	doi: 10.1038/ng.2799
27500726	Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.	Nat Med	2016 Sep	Shen CH	doi: 10.1038/nm.4155
28819029	Loss of Tumor Suppressor STAG2 Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells.	Cancer Res	2017 Oct 15	Daniloski Z	doi: 10.1158/0008-5472.CAN-17-1260
26838030	Complete loss of STAG2 expression is an indicator of good prognosis in patients with bladder cancer.	Tumour Biol	2016 Aug	Qiao Y	doi: 10.1007/s13277-016-4894-4
24121789	Frequent truncating mutations of STAG2 in bladder cancer.	Nat Genet	2013 Dec	Solomon DA	doi: 10.1038/ng.2800
25867412	Loss of STAG2 causes aneuploidy in normal human bladder cells.	Genet Mol Res	2015 Mar 30	Li X	doi: 10.4238/2015.March.30.24.
24270882	Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes.	Hum Mol Genet	2014 Apr 15	Taylor CF	doi: 10.1093/hmg/ddt589
27207471	Cohesin mutations in human cancer.	Biochim Biophys Acta	2016 Aug	Hill VK	doi: 10.1016/j.bbcan.2016.05.002
28967037	Loss of Stromal Antigen 2 (STAG2) Expression in Upper Urinary Tract Carcinoma: Differential Prognostic Effect According to the Ki-67 Proliferating Index.	Ann Surg Oncol	2017 Dec	Miyakawa J	doi: 10.1245/s10434-017-6097-7
29501732	The role of STAG2 in bladder cancer.	Pharmacol Res	2018 May	Aquila L	doi: 10.1016/j.phrs.2018.02.025

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chrX	124081516	Missense_Mutation	novel	A971V	0.92
BLCA	chrX	124076438	Frame_Shift_Ins	novel	*Y889Lfs9**	0.88
BLCA	chrX	124063161	Nonsense_Mutation	NA	Q593*	0.9
BLCA	chrX	124045360	Missense_Mutation	novel	T220I	0.08
BLCA	chrX	124083530	Nonsense_Mutation	NA	R1012*	1
BLCA	chrX	124056144	Frame_Shift_Del	novel	*L405Sfs20**	0.73
BLCA	chrX	124045274	Missense_Mutation	novel	I191M	0.94
BLCA	chrX	124068625	Missense_Mutation	novel	L776P	0.45
BLCA	chrX	124056179	Silent	NA	L416L	0.43
BLCA	chrX	124071184	Silent	novel	F798F	0.74
BLCA	chrX	124071292	Silent	novel	F834F	0.77
BLCA	chrX	124037539	Frame_Shift_Del	novel	*D101Lfs8**	0.92
BLCA	chrX	124063161	Nonsense_Mutation	NA	Q593*	0.74
BLCA	chrX	124062952	Missense_Mutation	novel	I563M	0.89
BLCA	chrX	124045347	Nonsense_Mutation	NA	R216*	0.06
BLCA	chrX	124056156	Missense_Mutation	novel	D409H	0.2
BLCA	chrX	124083530	Nonsense_Mutation	NA	R1012*	0.08
BLCA	chrX	124066189	Missense_Mutation	NA	S704L	0.37
BLCA	chrX	124068615	Nonsense_Mutation	NA	Q773*	0.95
BLCA	chrX	124050205	Nonsense_Mutation	NA	R305*	0.25
BLCA	chrX	124025865	Missense_Mutation	novel	D24H	0.39
BLCA	chrX	124050237	Nonsense_Mutation	novel	W315*	0.35
BLCA	chrX	124049003	Splice_Site	NA	X274_splice	0.48
BLCA	chrX	124061292	Nonsense_Mutation	novel	W495*	0.98
BLCA	chrX	124090737	Frame_Shift_Del	novel	*E1147Dfs16**	0.55
BLCA	chrX	124063901	Frame_Shift_Ins	novel	*T626Nfs9**	0.41
BLCA	chrX	124050283	Nonsense_Mutation	novel	Y331*	0.89
BLCA	chrX	124045347	Silent	NA	R216R	0.38
BLCA	chrX	124063161	Nonsense_Mutation	NA	Q593*	0.97
BLCA	chrX	124045327	Frame_Shift_Del	novel	*D209Vfs29**	0.64
BLCA	chrX	124094107	In_Frame_Del	novel	E1187_D1192del	0.2
BLCA	chrX	124037605	Nonsense_Mutation	NA	Q123*	0.95
BLCA	chrX	124045342	Missense_Mutation	novel	A214V	0.47
BLCA	chrX	124050279	Frame_Shift_Del	novel	*K330Ifs8**	0.9
BLCA	chrX	124086622	Frame_Shift_Del	novel	*Y1044Tfs6**	0.89
BLCA	chrX	124062901	Splice_Site	novel	X547_splice	0.8
BLCA	chrX	124050271	Frame_Shift_Del	novel	*S327Vfs3**	0.94
BLCA	chrX	124050273	Frame_Shift_Del	novel	Y328*	0.94
BLCA	chrX	124090699	Frame_Shift_Del	novel	*E1135Ifs21**	0.26
BLCA	chrX	124068595	Missense_Mutation	novel	R766K	0.64
BLCA	chrX	124076402	Frame_Shift_Del	novel	*K870Ifs21**	0.7
BLCA	chrX	124063161	Nonsense_Mutation	NA	Q593*	0.67
BLCA	chrX	124037622	Splice_Site	novel	X129_splice	0.11
BLCA	chrX	124062914	Nonsense_Mutation	novel	K551*	0.63
BLCA	chrX	124037592	Silent	novel	I118I	0.09
BLCA	chrX	124076348	Missense_Mutation	novel	D850E	0.14
BLCA	chrX	124076349	Nonsense_Mutation	novel	E851*	0.13
BLCA	chrX	124068612	Missense_Mutation	rs762388218	C772R	0.4
BLCA	chrX	124051211	Missense_Mutation	NA	R370W	0.42
BLCA	chrX	124094112	Nonsense_Mutation	novel	G1188*	0.7
BLCA	chrX	124078030	Frame_Shift_Ins	novel	K917*	0.9
BLCA	chrX	124063161	Nonsense_Mutation	NA	Q593*	0.48
BLCA	chrX	124078023	Nonsense_Mutation	NA	Q914*	0.24
BLCA	chrX	124086578	Nonsense_Mutation	NA	Q1029*	0.96
BLCA	chrX	124086670	Silent	novel	V1059V	1
BLCA	chrX	124045324	Missense_Mutation	novel	S208Y	0.79
BLCA	chrX	124063953	Frame_Shift_Del	novel	*E643Lfs14**	0.92
BLCA	chrX	124045347	Nonsense_Mutation	NA	R216*	0.84
BLCA	chrX	124066260	Nonsense_Mutation	NA	Q728*	0.76
BLCA	chrX	124056225	Missense_Mutation	novel	L432F	0.96
BLCA	chrX	124081491	Nonsense_Mutation	NA	Q963*	0.88
BLCA	chrX	124066174	Splice_Site	NA	X699_splice	0.43
BLCA	chrX	124090714	Missense_Mutation	novel	M1139I	0.12
BLCA	chrX	124062973	Silent	novel	A570A	0.31
BLCA	chrX	124063180	Frame_Shift_Ins	novel	*Y600Ifs35**	0.89
BLCA	chrX	124061309	Nonsense_Mutation	novel	L501*	0.53
BLCA	chrX	124086606	Nonsense_Mutation	NA	W1038*	0.84
BLCA	chrX	124071154	Silent	novel	F788F	0.64
BLCA	chrX	124076337	Nonsense_Mutation	NA	Q847*	0.62
BRCA	chrX	124049017	Missense_Mutation	NA	Q278E	0.22
BRCA	chrX	124047441	Missense_Mutation	NA	R252Q	0.21
BRCA	chrX	124061854	Nonsense_Mutation	NA	G540*	0.29
BRCA	chrX	124077984	Missense_Mutation	NA	K901E	0.34
BRCA	chrX	124090914	Intron	novel		0.07
BRCA	chrX	124065943	Missense_Mutation	NA	H698R	0.24
BRCA	chrX	124022604	5'UTR	novel		0.24
BRCA	chrX	124066174	Splice_Site	NA	X699_splice	0.23
BRCA	chrX	124083494	Missense_Mutation	novel	L1000F	0.42
BRCA	chrX	124062941	Missense_Mutation	NA	R560W	0.45
BRCA	chrX	124101172	3'Flank	novel		0.13
BRCA	chrX	124056165	Missense_Mutation	novel	N412Y	0.05
BRCA	chrX	124095395	Silent	novel	E1206E	0.06
BRCA	chrX	124056153	Missense_Mutation	novel	E408K	0.16
BRCA	chrX	124071161	Silent	novel	L791L	0.06
BRCA	chrX	124062975	Missense_Mutation	NA	L571P	0.15
BRCA	chrX	124063909	Missense_Mutation	novel	V628A	0.19
BRCA	chrX	124090682	Missense_Mutation	NA	P1129S	0.11
BRCA	chrX	124045347	Nonsense_Mutation	NA	R216*	0.06
BRCA	chrX	124045200	Nonsense_Mutation	NA	Q167*	0.23
BRCA	chrX	124031043	Missense_Mutation	NA	R69Q	0.3
BRCA	chrX	124045256	Silent	NA	Q185Q	0.15
BRCA	chrX	124100771	3'UTR	novel		0.19
BRCA	chrX	124090870	Intron	novel		0.05
BRCA	chrX	124090872	Intron	novel		0.02
BRCA	chrX	124100769	3'UTR	novel		0.06
BRCA	chrX	123960795	5'Flank	novel		0.08
BRCA	chrX	124101078	3'Flank	novel		0.14
BRCA	chrX	124061263	Missense_Mutation	NA	D486N	0.18
BRCA	chrX	124081496	Silent	rs753646242	L964L	0.08
CESC	chrX	124090660	Silent	novel	L1121L	0.1
CESC	chrX	124061230	Missense_Mutation	novel	E475K	0.15
CESC	chrX	124101740	3'Flank	novel		0.42
CESC	chrX	124065923	Silent	novel	L691L	0.17
CESC	chrX	124095419	Missense_Mutation	NA	F1214L	0.49
CESC	chrX	124100764	3'UTR	novel		0.25
CESC	chrX	124050199	Missense_Mutation	NA	E303K	0.11
CESC	chrX	124031113	Missense_Mutation	NA	K92N	0.16
CESC	chrX	124037592	Frame_Shift_Ins	novel	N119*	0.09
CESC	chrX	124045366	Missense_Mutation	novel	A222V	0.45
CESC	chrX	124100950	3'Flank	novel		0.31
CESC	chrX	124101668	3'Flank	novel		0.46
CESC	chrX	124102117	3'Flank	novel		0.28
CESC	chrX	124049062	Missense_Mutation	novel	F293L	0.2
CESC	chrX	124061832	Silent	rs778891520	A532A	0.17
CESC	chrX	124045330	Nonsense_Mutation	novel	S210*	0.52
CESC	chrX	124063157	In_Frame_Ins	novel	P592_L605dup	0.12
CESC	chrX	123961825	5'UTR	novel		0.82
CHOL	chrX	124066403	Missense_Mutation	novel	Q744H	0.94
COAD	chrX	124047406	Silent	NA	N240N	0.7
COAD	chrX	124037596	Frame_Shift_Del	NA	*F121Lfs24**	0.35
COAD	chrX	124042603	Silent	NA	Q140Q	0.33
COAD	chrX	124057954	Missense_Mutation	NA	V465F	0.11
COAD	chrX	124090961	Intron	novel		0.11
COAD	chrX	124022573	5'UTR	novel		0.24
COAD	chrX	124031012	Missense_Mutation	novel	G59R	0.06
COAD	chrX	124095400	Frame_Shift_Del	novel	*T1208Kfs3**	0.87
COAD	chrX	124081485	Missense_Mutation	novel	L961F	0.06
COAD	chrX	124083531	Missense_Mutation	NA	R1012Q	0.7
COAD	chrX	124051171	Silent	NA	Y356Y	0.44
COAD	chrX	124056156	Missense_Mutation	rs773224655	D409Y	0.26
COAD	chrX	124086690	Missense_Mutation	novel	R1066Q	0.6
DLBC	chrX	124049042	Missense_Mutation	novel	N286I	0.08
ESCA	chrX	124081524	Missense_Mutation	novel	H974Y	1
ESCA	chrX	124042578	Missense_Mutation	novel	T132K	0.13
ESCA	chrX	124101303	3'Flank	novel		0.09
ESCA	chrX	124101305	3'Flank	novel		0.08
ESCA	chrX	124101049	3'Flank	novel		0.32
ESCA	chrX	124031126	Splice_Site	novel	X96_splice	0.91
GBM	chrX	124037566	Nonsense_Mutation	NA	R110*	0.92
GBM	chrX	124042647	Splice_Site	NA	X154_splice	0.81
GBM	chrX	124063934	Nonsense_Mutation	NA	Y636*	0.6
GBM	chrX	124081501	Missense_Mutation	NA	T966K	0.24
GBM	chrX	124071235	Nonsense_Mutation	NA	Y815*	0.34
GBM	chrX	124071196	Frame_Shift_Del	NA	*M803Vfs5**	0.62
GBM	chrX	124057977	Frame_Shift_Del	novel		0.59
GBM	chrX	124022643	Nonsense_Mutation	novel	E6*	0.26
GBM	chrX	124071161	Missense_Mutation	novel	L791M	0.3
GBM	chrX	124064051	Missense_Mutation	NA	E675D	0.33
GBM	chrX	124042629	Frame_Shift_Del	NA	*T149Mfs34**	0.44
GBM	chrX	124042630	Silent	NA	T149T	0.44
GBM	chrX	124042620	Frame_Shift_Ins	novel	*M148Nfs3**	0.5
GBM	chrX	124031051	Missense_Mutation	novel	G72S	0.37
GBM	chrX	124025843	Silent	novel	E16E	0.48
GBM	chrX	124062982	Missense_Mutation	novel	Q573H	0.33
GBM	chrX	124063898	Frame_Shift_Del	novel	*D625Yfs9**	0.23
GBM	chrX	124083427	Frame_Shift_Ins	novel	*K983Nfs6**	0.28
HNSC	chrX	124063161	Nonsense_Mutation	NA	Q593*	0.22
HNSC	chrX	124066395	Missense_Mutation	novel	L742I	0.12
HNSC	chrX	124083494	Missense_Mutation	novel	L1000F	0.38
HNSC	chrX	124083543	Missense_Mutation	novel	R1016K	0.44
HNSC	chrX	124061778	Silent	novel	T514T	0.5
HNSC	chrX	124062967	Silent	NA	A568A	0.28
HNSC	chrX	124063985	Frame_Shift_Ins	novel	*R654Nfs6**	0.07
HNSC	chrX	124063987	Frame_Shift_Ins	novel	*R654Sfs7**	0.07
HNSC	chrX	124047473	Silent	novel	R263R	0.16
HNSC	chrX	124061860	Missense_Mutation	novel	G542W	0.15
HNSC	chrX	124030984	Silent	novel	G49G	0.72
HNSC	chrX	124025897	Silent	novel	N34N	0.06
KIRC	chrX	124063932	Nonsense_Mutation	NA	Y636*	0.59
KIRC	chrX	124061778	Frame_Shift_Del	NA	D515*	0.33
KIRC	chrX	124064025	Missense_Mutation	rs776905490	R667W	0.15
KIRC	chrX	124045304	Missense_Mutation	NA	I201M	0.22
KIRC	chrX	124061873	Frame_Shift_Del	novel		0.54
KIRC	chrX	124063194	Nonsense_Mutation	NA	R604*	0.67
KIRC	chrX	124066420	Frame_Shift_Del	novel	*E750Dfs31**	0.27
KIRC	chrX	124045348	Missense_Mutation	NA	R216Q	0.35
KIRC	chrX	124083478	Frame_Shift_Del	novel	L995*	0.54
KIRC	chrX	124050226	Missense_Mutation	NA	I312L	0.2
KIRP	chrX	124071254	Nonsense_Mutation	NA	Q822*	0.93
KIRP	chrX	124061778	Frame_Shift_Del	NA	D515*	0.06
KIRP	chrX	124056220	Frame_Shift_Del	novel	*E430Dfs18**	0.35
KIRP	chrX	124078009	Frame_Shift_Del	novel	*I910Tfs20**	0.79
KIRP	chrX	124042619	Nonsense_Mutation	NA	R146*	0.86
KIRP	chrX	124050265	Frame_Shift_Del	novel	*N325Tfs4**	0.37
KIRP	chrX	124063984	Nonsense_Mutation	NA	S653*	0.25
KIRP	chrX	124095443	Missense_Mutation	novel	D1222E	0.17
KIRP	chrX	124068606	Nonsense_Mutation	NA	Q770*	0.3
LAML	chrX	124057978	Splice_Site	NA	X472_splice	0.33
LAML	chrX	124090765	Splice_Site	NA	X1156_splice	0.08
LAML	chrX	124061284	Nonsense_Mutation	novel	K493*	0.1
LGG	chrX	124045347	Nonsense_Mutation	NA	R216*	0.72
LGG	chrX	124045271	Silent	novel	I190I	0.45
LGG	chrX	124094023	Missense_Mutation	novel	R1158H	0.35
LGG	chrX	124063117	Missense_Mutation	NA	Y578F	0.35
LIHC	chrX	124049021	Missense_Mutation	novel	D279G	0.3
LIHC	chrX	124042593	In_Frame_Del	novel	R137_Q140delinsK	0.32
LIHC	chrX	124063190	Silent	novel	T602T	0.32
LIHC	chrX	124061784	Silent	NA	R516R	0.17
LIHC	chrX	124062995	Splice_Site	novel	X577_splice	0.62
LIHC	chrX	124057953	Silent	novel	L464L	0.1
LIHC	chrX	124071224	Missense_Mutation	novel	P812S	0.17
LUAD	chrX	124057954	Missense_Mutation	NA	V465F	0.19
LUAD	chrX	124068645	Missense_Mutation	NA	V783F	0.3
LUAD	chrX	124077980	Silent	novel	I899I	0.08
LUAD	chrX	124064016	Frame_Shift_Del	novel	*K664Nfs28**	0.35
LUAD	chrX	124090765	Splice_Site	NA	X1156_splice	0.45
LUAD	chrX	124094040	Nonsense_Mutation	novel	E1164*	0.14
LUAD	chrX	124056225	Missense_Mutation	NA	L432V	0.31
LUAD	chrX	124061858	Missense_Mutation	NA	R541K	0.36
LUAD	chrX	124083487	Missense_Mutation	NA	L997F	0.78
LUAD	chrX	124083457	Silent	rs761983006	P987P	0.09
LUAD	chrX	124095390	Nonsense_Mutation	NA	R1205*	0.18
LUAD	chrX	124045248	Missense_Mutation	novel	V183L	0.14
LUAD	chrX	124064049	Missense_Mutation	novel	E675Q	0.22
LUAD	chrX	124030972	Missense_Mutation	novel	K45N	0.24
LUAD	chrX	124056180	Missense_Mutation	NA	V417L	0.25
LUAD	chrX	124077978	Missense_Mutation	NA	I899V	0.81
LUAD	chrX	124066176	Missense_Mutation	novel	A700S	0.1
LUAD	chrX	124025840	Missense_Mutation	novel	Q15H	0.11
LUAD	chrX	124045362	Missense_Mutation	NA	L221M	0.17
LUAD	chrX	124066387	Missense_Mutation	NA	Y739C	0.23
LUAD	chrX	124071321	Missense_Mutation	novel	A844E	0.07
LUAD	chrX	124076371	Missense_Mutation	NA	L858P	0.06
LUAD	chrX	124063937	Missense_Mutation	novel	H637Q	0.25
LUAD	chrX	124086593	Nonsense_Mutation	NA	R1034*	0.22
LUAD	chrX	124090913	Intron	novel		0.22
LUSC	chrX	124066227	Frame_Shift_Del	novel	*T718Lfs23**	0.45
LUSC	chrX	124071217	Missense_Mutation	NA	M809I	0.11
LUSC	chrX	124071285	Missense_Mutation	NA	H832R	0.76
LUSC	chrX	124063884	Missense_Mutation	NA	V620L	0.38
LUSC	chrX	124062959	Frame_Shift_Ins	novel	*A568Cfs20**	0.55
LUSC	chrX	124051219	Missense_Mutation	novel	K372N	0.26
LUSC	chrX	124051220	Splice_Site	novel	X372_splice	0.27
LUSC	chrX	124090682	Missense_Mutation	NA	P1129S	0.23
LUSC	chrX	124063874	Missense_Mutation	novel	I616M	0.13
LUSC	chrX	124071316	Missense_Mutation	novel	N842K	0.2
LUSC	chrX	124090912	Intron	novel		0.23
LUSC	chrX	124025854	Frame_Shift_Ins	novel	*S22Ffs3**	0.67
LUSC	chrX	124062977	Missense_Mutation	NA	P572S	0.78
LUSC	chrX	124066404	Frame_Shift_Ins	novel	*A746Cfs2**	0.11
LUSC	chrX	124022573	5'UTR	novel		0.3
LUSC	chrX	124094145	Splice_Site	rs777484689	X1198_splice	0.23
MESO	chrX	124047497	Silent	novel	R271R	0.45
MESO	chrX	124045348	Missense_Mutation	novel	R216L	0.6
OV	chrX	124066240	Missense_Mutation	NA	E721V	0.12
OV	chrX	124100704	3'UTR	novel		0.48
OV	chrX	124045251	Missense_Mutation	rs765673108	R184W	0.31
OV	chrX	124094145	Splice_Site	NA	X1198_splice	0.33
OV	chrX	124065873	Splice_Region	novel		0.48
PAAD	chrX	124042627	Missense_Mutation	novel	M148I	0.07
PAAD	chrX	124047438	Missense_Mutation	novel	E251A	0.05
PAAD	chrX	124047454	Missense_Mutation	novel	I256M	0.05
PCPG	chrX	124037556	Frame_Shift_Ins	novel	*H108Afs2**	0.43
PRAD	chrX	124045226	Silent	novel	F175F	0.1
READ	chrX	124090943	Intron	NA		0.51
READ	chrX	124045351	Missense_Mutation	NA	H217R	0.29
READ	chrX	124031080	Silent	NA	N81N	0.15
READ	chrX	124050192	Silent	rs757136748	A300A	0.05
SARC	chrX	124037566	Nonsense_Mutation	NA	R110*	0.9
SKCM	chrX	124066189	Missense_Mutation	NA	S704L	0.34
SKCM	chrX	124090860	Intron	novel		0.31
SKCM	chrX	124037543	Frame_Shift_Ins	novel	*E104Dfs7**	0.34
SKCM	chrX	124061790	Silent	novel	E518E	0.32
SKCM	chrX	124094083	Missense_Mutation	NA	S1178L	0.9
SKCM	chrX	124071276	Missense_Mutation	NA	I829N	0.21
SKCM	chrX	124045290	Frame_Shift_Del	novel	*M197Wfs28**	0.58
SKCM	chrX	124047358	Missense_Mutation	NA	M224I	0.36
SKCM	chrX	124056172	Missense_Mutation	NA	Y414F	0.24
SKCM	chrX	124042620	Missense_Mutation	novel	R146Q	0.34
SKCM	chrX	124066178	Silent	NA	A700A	0.21
SKCM	chrX	124061867	Missense_Mutation	NA	G544E	0.33
SKCM	chrX	124066224	Missense_Mutation	NA	L716V	0.26
SKCM	chrX	124086590	Nonsense_Mutation	NA	R1033*	0.73
SKCM	chrX	124065926	Silent	rs778042166	K692K	0.76
STAD	chrX	124022574	5'UTR	novel		0.25
STAD	chrX	124042624	Frame_Shift_Ins	novel	*M148Dfs3**	0.42
STAD	chrX	124086573	Missense_Mutation	NA	T1027N	0.17
STAD	chrX	124030967	Frame_Shift_Del	novel	*G46Afs25**	0.18
STAD	chrX	124045223	Frame_Shift_Del	novel	*C176Vfs7**	0.69
STAD	chrX	124063141	Missense_Mutation	NA	T586S	0.52
STAD	chrX	124031025	Missense_Mutation	NA	P63H	0.41
STAD	chrX	124051212	Missense_Mutation	NA	R370Q	0.64
STAD	chrX	124037577	Silent	NA	A113A	0.81
STAD	chrX	124068584	Silent	NA	K762K	0.85
STAD	chrX	124037567	Missense_Mutation	novel	R110Q	0.82
STAD	chrX	124086656	Missense_Mutation	NA	D1055N	0.09
STAD	chrX	124071281	Missense_Mutation	NA	D831N	0.6
STAD	chrX	124086710	Missense_Mutation	novel	K1073E	0.13
STAD	chrX	124083456	Missense_Mutation	rs768937075	P987Q	0.17
STAD	chrX	124062981	Missense_Mutation	NA	Q573R	0.17
STAD	chrX	124083532	Silent	NA	R1012R	0.1
STAD	chrX	124051180	Silent	NA	E359E	0.58
STAD	chrX	124095429	Missense_Mutation	NA	A1218T	0.42
TGCT	chrX	124050253	Missense_Mutation	novel	D321Y	0.3
THCA	chrX	124078012	Missense_Mutation	NA	I910R	0.26
THYM	chrX	124049076	Nonsense_Mutation	NA	Y297*	0.14
UCEC	chrX	124047461	Nonsense_Mutation	NA	R259*	0.63
UCEC	chrX	124025885	Silent	NA	I30I	0.33
UCEC	chrX	124031054	Missense_Mutation	NA	H73Y	0.3
UCEC	chrX	124047395	Missense_Mutation	NA	L237I	0.27
UCEC	chrX	124056144	Missense_Mutation	NA	L405I	0.32
UCEC	chrX	124095446	Silent	NA	E1223E	0.3
UCEC	chrX	124022603	5'UTR	novel		0.1
UCEC	chrX	124025856	Missense_Mutation	novel	F21I	0.12
UCEC	chrX	124063854	Missense_Mutation	novel	D610N	0.31
UCEC	chrX	124090864	Intron	novel		0.26
UCEC	chrX	124101997	3'Flank	novel		0.17
UCEC	chrX	124057877	Missense_Mutation	rs777167759	R439H	0.47
UCEC	chrX	124076457	Missense_Mutation	NA	K887E	0.3
UCEC	chrX	124037560	Missense_Mutation	novel	H108Y	0.24
UCEC	chrX	124042620	Missense_Mutation	novel	R146Q	0.42
UCEC	chrX	124056195	Missense_Mutation	novel	R422W	0.43
UCEC	chrX	124061817	Silent	novel	C527C	0.29
UCEC	chrX	124076383	Missense_Mutation	NA	R862I	0.05
UCEC	chrX	124086704	Missense_Mutation	novel	R1071W	0.25
UCEC	chrX	124090922	Intron	novel		0.45
UCEC	chrX	124102497	3'Flank	novel		0.33
UCEC	chrX	124102267	3'Flank	novel		0.11
UCEC	chrX	124042639	Silent	NA	F152F	0.47
UCEC	chrX	124066223	Silent	NA	L715L	0.4
UCEC	chrX	124100617	3'UTR	novel		0.44
UCEC	chrX	124077987	Nonsense_Mutation	novel	E902*	0.38
UCEC	chrX	124086713	Missense_Mutation	novel	K1074Q	0.47
UCEC	chrX	124061277	Missense_Mutation	novel	E490D	0.45
UCEC	chrX	124090633	Silent	novel	T1112T	0.06
UCEC	chrX	123960717	5'Flank	novel		0.21
UCEC	chrX	124101589	3'Flank	novel		0.27
UCEC	chrX	124101839	3'Flank	novel		0.12
UCEC	chrX	124056219	Nonsense_Mutation	novel	E430*	0.28
UCEC	chrX	124066392	Missense_Mutation	novel	I741L	0.17
UCEC	chrX	124095419	Missense_Mutation	NA	F1214L	0.42
UCEC	chrX	124042640	Missense_Mutation	NA	D153N	0.1
UCEC	chrX	124056144	Missense_Mutation	NA	L405I	0.22
UCEC	chrX	124076380	Missense_Mutation	NA	R861K	0.23
UCEC	chrX	124094139	Missense_Mutation	NA	D1197N	0.15
UCEC	chrX	124063855	Missense_Mutation	NA	D610G	0.23
UCEC	chrX	124077990	Missense_Mutation	novel	T903S	0.37
UCEC	chrX	124061873	Missense_Mutation	novel	R546K	0.35
UCEC	chrX	124037559	Missense_Mutation	novel	K107N	0.22
UCEC	chrX	124078053	Nonsense_Mutation	novel	Q924*	0.13
UCEC	chrX	124100771	3'UTR	novel		0.22
UCEC	chrX	124064026	Missense_Mutation	rs369728409	R667Q	0.05
UCEC	chrX	124065882	Nonsense_Mutation	NA	E678*	0.23
UCEC	chrX	124083509	Nonsense_Mutation	novel	E1005*	0.25
UCEC	chrX	124101173	3'Flank	novel		0.24
UCEC	chrX	124051212	Missense_Mutation	NA	R370Q	0.47
UCEC	chrX	124102548	3'Flank	novel		0.55
UCEC	chrX	124090661	Missense_Mutation	novel	T1122A	0.48
UCEC	chrX	124095391	Missense_Mutation	NA	R1205Q	0.1
UCEC	chrX	124102307	3'Flank	novel		0.18
UCEC	chrX	124102308	3'Flank	novel		0.08
UCEC	chrX	124063889	Silent	novel	E621E	0.32
UCEC	chrX	124100941	3'Flank	novel		0.42
UCEC	chrX	124101965	3'Flank	novel		0.29
UCEC	chrX	124102140	3'Flank	novel		0.36
UCEC	chrX	124102600	3'Flank	novel		0.25
UCEC	chrX	124045292	Missense_Mutation	novel	M197I	0.52
UCEC	chrX	124077958	Missense_Mutation	novel	Y892C	0.34
UCEC	chrX	124101946	3'Flank	novel		0.36
UCEC	chrX	124062928	Silent	NA	T555T	0.2
UCEC	chrX	124037552	Missense_Mutation	NA	S105L	0.13
UCEC	chrX	124086704	Missense_Mutation	novel	R1071W	0.45
UCEC	chrX	124102471	3'Flank	novel		0.4
UCEC	chrX	124083488	Missense_Mutation	NA	A998T	0.17
UCEC	chrX	124042634	Nonsense_Mutation	NA	E151*	0.3
UCEC	chrX	124083494	Missense_Mutation	novel	L1000I	0.29
UCEC	chrX	124101173	3'Flank	novel		0.26
UCEC	chrX	124031052	Missense_Mutation	novel	G72V	0.44
UCEC	chrX	124071317	Missense_Mutation	novel	S843G	0.06
UCEC	chrX	124090599	Missense_Mutation	novel	S1101N	0.4
UCEC	chrX	124095375	Missense_Mutation	novel	P1200S	0.44
UCEC	chrX	124100666	3'UTR	novel		0.49
UCEC	chrX	124101098	3'Flank	novel		0.42
UCEC	chrX	124102304	3'Flank	novel		0.27
UCEC	chrX	124100688	3'UTR	novel		0.15
UCEC	chrX	124101151	3'Flank	novel		0.26
UCEC	chrX	124050192	Silent	novel	A300A	0.26
UCEC	chrX	124056204	Missense_Mutation	novel	A425T	0.5
UCEC	chrX	124050294	Missense_Mutation	novel	W334C	0.06
UCEC	chrX	124050191	Missense_Mutation	NA	A300V	0.44
UCEC	chrX	124057954	Missense_Mutation	NA	V465F	0.24
UCEC	chrX	124071223	Silent	NA	E811E	0.27
UCEC	chrX	124051177	Missense_Mutation	novel	K358N	0.3
UCEC	chrX	124051343	Missense_Mutation	novel	K382T	0.31
UCEC	chrX	124051345	Nonsense_Mutation	NA	E383*	0.33
UCEC	chrX	124063962	Missense_Mutation	novel	I646L	0.44
UCEC	chrX	124078050	Missense_Mutation	novel	L923M	0.37
UCEC	chrX	124102025	3'Flank	novel		0.14
UCEC	chrX	123960687	5'Flank	novel		0.63
UCEC	chrX	124025890	Missense_Mutation	novel	G32E	0.25
UCEC	chrX	124057958	Missense_Mutation	novel	F466S	0.39
UCEC	chrX	124063975	Missense_Mutation	novel	V650A	0.34
UCEC	chrX	124083429	Missense_Mutation	novel	I978T	0.37
UCEC	chrX	123961855	Splice_Region	novel		0.42
UCEC	chrX	124066390	Frame_Shift_Del	NA	*V740Efs9**	0.32
UCEC	chrX	124063152	Nonsense_Mutation	NA	Q590*	0.32
UCEC	chrX	124100771	3'UTR	novel		0.13
UCEC	chrX	124100772	3'UTR	novel		0.13
UCEC	chrX	124083531	Missense_Mutation	NA	R1012Q	0.16
UCEC	chrX	124086744	Missense_Mutation	novel	V1084A	0.19
UCEC	chrX	124094035	Missense_Mutation	novel	L1162R	0.17
UCEC	chrX	124102350	3'Flank	novel		0.14
UCEC	chrX	124102468	3'Flank	novel		0.17
UCEC	chrX	124094022	Missense_Mutation	NA	R1158C	0.14
UCEC	chrX	124042639	Silent	NA	F152F	0.28
UCEC	chrX	124094031	Missense_Mutation	novel	S1161R	0.35
UCEC	chrX	124100934	3'Flank	novel		0.22
UCEC	chrX	124101313	3'Flank	novel		0.11
UCEC	chrX	124022638	Missense_Mutation	novel	A4V	0.31
UCEC	chrX	124049077	Missense_Mutation	NA	R298C	0.36
UCEC	chrX	124068615	Nonsense_Mutation	NA	Q773*	0.36
UCEC	chrX	124090722	Missense_Mutation	novel	Y1142C	0.29
UCEC	chrX	124101084	3'Flank	novel		0.48
UCEC	chrX	124101886	3'Flank	novel		0.44
UCEC	chrX	123960835	5'Flank	novel		0.45
UCEC	chrX	124047367	Missense_Mutation	novel	M227I	0.48
UCEC	chrX	124051362	Silent	novel	V388V	0.29
UCEC	chrX	124063974	Missense_Mutation	novel	V650L	0.53
UCEC	chrX	124071159	Missense_Mutation	novel	I790S	0.5
UCEC	chrX	124101395	3'Flank	novel		0.27
UCEC	chrX	124101767	3'Flank	novel		0.37
UCEC	chrX	124061244	Silent	novel	Y479Y	0.05
UCEC	chrX	124025854	Missense_Mutation	novel	H20R	0.38
UCEC	chrX	124042619	Nonsense_Mutation	NA	R146*	0.36
UCEC	chrX	124042640	Missense_Mutation	NA	D153N	0.43
UCEC	chrX	124081452	Nonsense_Mutation	NA	E950*	0.07
UCEC	chrX	124063192	Missense_Mutation	novel	G603E	0.18
UCEC	chrX	124083431	Nonsense_Mutation	NA	E979*	0.22
UCEC	chrX	124094037	Missense_Mutation	novel	M1163L	0.13
UCEC	chrX	124095397	Missense_Mutation	novel	R1207I	0.18
UCEC	chrX	123961815	5'UTR	novel		0.23
UCEC	chrX	124062958	Missense_Mutation	novel	E565D	0.24
UCEC	chrX	124101467	3'Flank	novel		0.28
UCEC	chrX	124025873	Silent	novel	D26D	0.46
UCEC	chrX	124057955	Frame_Shift_Del	novel	*F467Sfs3**	0.39
UCEC	chrX	124045283	Missense_Mutation	NA	E194D	0.29
UCEC	chrX	124057877	Missense_Mutation	rs777167759	R439H	0.08
UCEC	chrX	124090681	Missense_Mutation	NA	E1128D	0.34
UCEC	chrX	124101200	3'Flank	novel		0.52
UCEC	chrX	124063148	Silent	novel	L588L	0.29
UCEC	chrX	124086690	Frame_Shift_Del	NA	*S1068Qfs37**	0.08
UCEC	chrX	124045301	Silent	NA	V200V	0.17
UCEC	chrX	124100730	3'UTR	novel		0.27
UCEC	chrX	124081452	Nonsense_Mutation	NA	E950*	0.39
UCEC	chrX	124090616	Nonsense_Mutation	NA	E1107*	0.28
UCEC	chrX	124100772	3'UTR	novel		0.5
UCEC	chrX	124061831	Missense_Mutation	NA	A532V	0.41
UCEC	chrX	124047449	Missense_Mutation	novel	M255V	0.28
UCEC	chrX	124077995	Missense_Mutation	novel	M904I	0.35
UCEC	chrX	124101578	3'Flank	novel		0.3
UCEC	chrX	124042619	Nonsense_Mutation	NA	R146*	0.34
UCEC	chrX	124081461	Nonsense_Mutation	NA	R953*	0.29
UCEC	chrX	124066376	Missense_Mutation	novel	Q735H	0.35
UCEC	chrX	124057954	Missense_Mutation	NA	V465F	0.41
UCEC	chrX	124100863	3'UTR	novel		0.45
UCEC	chrX	124102378	3'Flank	novel		0.37
UCEC	chrX	123960756	5'Flank	novel		0.23
UCEC	chrX	124102100	3'Flank	novel		0.37
UCEC	chrX	124095386	Silent	NA	N1203N	0.3
UCEC	chrX	124068643	Missense_Mutation	NA	T782I	0.33
UCEC	chrX	124081444	Missense_Mutation	NA	G947A	0.28
UCEC	chrX	124095402	Nonsense_Mutation	novel	E1209*	0.35
UCEC	chrX	124101785	3'Flank	novel		0.43
UCS	chrX	124051345	Nonsense_Mutation	NA	E383*	0.21

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.0833	0.24013
KIRC	AMP	0.0284	0.12739
TGCT	DEL	0.0667	0.08422
THCA	DEL	0	0.21991
UCS	DEL	0.3036	0.063955

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00013	Kaplan-Meier Survival Analysis
SARC	0.013	Kaplan-Meier Survival Analysis
SKCM	0.00015	Kaplan-Meier Survival Analysis
LUSC	0.013	Kaplan-Meier Survival Analysis
ESCA	0.012	Kaplan-Meier Survival Analysis
TGCT	0.039	Kaplan-Meier Survival Analysis
KIRP	0.002	Kaplan-Meier Survival Analysis
CESC	0.014	Kaplan-Meier Survival Analysis
UCEC	0.042	Kaplan-Meier Survival Analysis
GBM	0.0018	Kaplan-Meier Survival Analysis
DLBC	0.038	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000101972 (Gene tree)
Gene ID: 10735
Gene Symbol: STAG2
Alias: SA-2|SCC3B|SA2
Full Name: stromal antigen 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 462,453 bases
Position: chrX:123,960,212-124,422,664
Accession: 11355
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000371160	STAG2-205	6045	XM_017029232	ENSP00000360202	1231 (aa)	XP_016884721	Q8N3U4
ENST00000371145	STAG2-203	4393	XM_005262359	ENSP00000360187	1268 (aa)	XP_005262416	Q8N3U4
ENST00000371157	STAG2-204	5991	XM_005262361	ENSP00000360199	1231 (aa)	XP_005262418	Q8N3U4
ENST00000466748	STAG2-214	873	-	-	- (aa)	-	-
ENST00000218089	STAG2-201	5218	XM_005262357	ENSP00000218089	1268 (aa)	XP_005262414	Q8N3U4
ENST00000394478	STAG2-207	676	-	ENSP00000377988	115 (aa)	-	B1AMT0
ENST00000435103	STAG2-209	742	-	ENSP00000405874	154 (aa)	-	B1AMT1
ENST00000458176	STAG2-212	845	-	ENSP00000401309	58 (aa)	-	E7ERE6
ENST00000394477	STAG2-206	385	-	ENSP00000377987	70 (aa)	-	B1AMS9
ENST00000483575	STAG2-218	864	-	-	- (aa)	-	-
ENST00000471107	STAG2-216	709	-	-	- (aa)	-	-
ENST00000455404	STAG2-211	2089	-	ENSP00000397265	548 (aa)	-	B1AMT4
ENST00000371144	STAG2-202	4281	-	ENSP00000360186	1231 (aa)	-	Q8N3U4
ENST00000435215	STAG2-210	798	-	ENSP00000392118	207 (aa)	-	B1AMT3
ENST00000475602	STAG2-217	356	-	-	- (aa)	-	-
ENST00000428941	STAG2-208	678	-	ENSP00000415103	169 (aa)	-	B1AMT2
ENST00000469481	STAG2-215	989	-	-	- (aa)	-	-
ENST00000458700	STAG2-213	296	-	ENSP00000405555	40 (aa)	-	B1AMS8

Gene Model

Click here to download ENSG00000101972's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000101972	Amyotrophic Lateral Sclerosis	9.962E-5	17362836

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000101972's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000775	chromosome, centromeric region	-	TAS	Component
GO:0000785	chromatin	21873635.	IBA	Component
GO:0000785	chromatin	16682347.	IDA	Component
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0005515	protein binding	15737063.15855230.16682347.17112726.17113138.17349791.17962804.18235444.19629043.20360068.20818333.22885700.23242214.25173175.26496610.30021884.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9305759.	TAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007062	sister chromatid cohesion	21873635.	IBA	Process
GO:0007062	sister chromatid cohesion	15917200.	IMP	Process
GO:0008278	cohesin complex	21873635.	IBA	Component
GO:0008278	cohesin complex	11590136.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016363	nuclear matrix	11590136.	IDA	Component
GO:0032876	negative regulation of DNA endoreduplication	15917200.	IMP	Process
GO:0051301	cell division	-	IEA	Process
GO:0051321	meiotic cell cycle	-	IEA	Process
GO:0097431	mitotic spindle pole	11590136.	IDA	Component
GO:1901673	regulation of mitotic spindle assembly	11590136.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.