EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17314274	Aberrant expression of X-linked genes RbAp46, Rsk4, and Cldn2 in breast cancer.	Mol Cancer Res	2007 Feb	Thakur A	-
14981905	Inducible expression of RbAp46 activates c-Jun NH2-terminal kinase-dependent apoptosis and suppresses progressive growth of tumor xenografts in nude mice.	Anticancer Res	2003 Nov-Dec	Zhang TF	-
14666671	Constitutive expression of Rb associated protein 46 (RbAp46) reverts transformed phenotypes of breast cancer cells.	Anticancer Res	2003 Sep-Oct	Zhang TF	-
19655816	Discovery of retinoblastoma-associated binding protein 46 as a novel prognostic marker for distant metastasis in nonsmall cell lung cancer by combined analysis of cancer cell secretome and pleural effusion proteome.	J Proteome Res	2009 Oct	Wang CL	doi: 10.1021/pr900160h.
25885317	Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity.	BMC Cancer	2015 Mar 25	Yeh HH	doi: 10.1186/s12885-015-1155-7.
18577416	The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression.	Mol Cell Endocrinol	2008 Sep 10	Creekmore AL	doi: 10.1016/j.mce.2008.05.016

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chrX	16853685	Missense_Mutation	novel	M252T	0.34
BLCA	chrX	16858828	Missense_Mutation	novel	V110A	0.44
BLCA	chrX	16863042	Missense_Mutation	novel	E74K	0.42
BLCA	chrX	16869215	Missense_Mutation	novel	E8Q	0.06
BLCA	chrX	16869192	Silent	novel	V15V	0.75
BLCA	chrX	16845884	Nonsense_Mutation	novel	E385*	0.71
BRCA	chrX	16852704	Intron	novel		0.06
BRCA	chrX	16853570	Intron	novel		0.26
BRCA	chrX	16845827	Splice_Site	NA	X403_splice	0.26
BRCA	chrX	16853725	Missense_Mutation	NA	E239Q	0.2
BRCA	chrX	16845058	Missense_Mutation	NA	E419K	0.13
BRCA	chrX	16869149	Missense_Mutation	NA	L30I	0.14
BRCA	chrX	16853034	Intron	novel		0.2
CESC	chrX	16852934	Intron	novel		0.06
CESC	chrX	16845088	Missense_Mutation	novel	N409Y	0.47
CESC	chrX	16857667	Missense_Mutation	novel	H175R	0.38
CESC	chrX	16852565	Missense_Mutation	NA	D317N	0.45
COAD	chrX	16852577	Missense_Mutation	NA	E313K	0.6
COAD	chrX	16852814	Missense_Mutation	NA	E274K	0.61
COAD	chrX	16869154	Missense_Mutation	NA	P28L	0.08
COAD	chrX	16853590	Intron	novel		0.6
COAD	chrX	16869194	Missense_Mutation	NA	V15I	0.53
COAD	chrX	16852071	Missense_Mutation	NA	R339S	0.76
COAD	chrX	16852825	Missense_Mutation	NA	A270V	0.43
COAD	chrX	16858775	Missense_Mutation	NA	R128C	0.74
COAD	chrX	16852966	Intron	novel		0.42
COAD	chrX	16869160	In_Frame_Del	NA	K25del	0.32
COAD	chrX	16853590	Intron	novel		0.2
COAD	chrX	16849296	Missense_Mutation	novel	I349N	0.18
COAD	chrX	16845833	Nonsense_Mutation	novel	Q402*	0.4
COAD	chrX	16858775	Missense_Mutation	NA	R128C	0.21
COAD	chrX	16852556	Missense_Mutation	NA	F320V	0.66
COAD	chrX	16852814	Missense_Mutation	NA	E274K	0.07
COAD	chrX	16845878	Frame_Shift_Del	NA	*W387Gfs82**	0.36
COAD	chrX	16852824	Nonsense_Mutation	novel	H271*	0.05
DLBC	chrX	16863014	Missense_Mutation	novel	V83G	0.91
ESCA	chrX	16870210	5'UTR	novel		0.72
ESCA	chrX	16845926	Frame_Shift_Del	novel	*G371Tfs4**	0.33
ESCA	chrX	16870401	5'UTR	novel		0.39
ESCA	chrX	16869098	Nonsense_Mutation	novel	Q47*	0.78
GBM	chrX	16853618	Intron	novel		0.41
GBM	chrX	16845874	Missense_Mutation	novel	V388A	0.28
HNSC	chrX	16853748	Missense_Mutation	novel	D231V	0.19
HNSC	chrX	16869140	Missense_Mutation	novel	L33V	0.63
HNSC	chrX	16852061	Missense_Mutation	novel	N342T	0.13
HNSC	chrX	16845857	Missense_Mutation	novel	E394Q	0.07
HNSC	chrX	16870109	5'UTR	novel		0.47
HNSC	chrX	16869119	Nonsense_Mutation	novel	Q40*	0.14
KIRP	chrX	16870079	5'UTR	novel		0.38
LGG	chrX	16852578	Silent	NA	F312F	0.4
LIHC	chrX	16870246	5'UTR	novel		0.86
LUAD	chrX	16869125	In_Frame_Del	novel	D32_H37del	0.11
LUAD	chrX	16849281	Nonsense_Mutation	novel	S354*	0.16
LUAD	chrX	16870090	5'UTR	novel		0.13
LUAD	chrX	16857658	Missense_Mutation	novel	E178G	0.27
LUAD	chrX	16852586	Frame_Shift_Del	novel	*H310Ifs32**	0.14
LUAD	chrX	16852066	Silent	NA	R340R	0.28
LUSC	chrX	16863030	Silent	NA	L78L	0.39
LUSC	chrX	16857647	Missense_Mutation	novel	L182V	0.19
OV	chrX	16852558	Frame_Shift_Ins	novel	*I319Nfs10**	0.08
OV	chrX	16852625	Missense_Mutation	NA	V297L	0.55
OV	chrX	16869157	Missense_Mutation	novel	T27R	0.23
OV	chrX	16852578	Silent	NA	F312F	0.39
PAAD	chrX	16858784	Missense_Mutation	novel	E125K	0.12
READ	chrX	16845091	Missense_Mutation	NA	Y408D	0.49
READ	chrX	16845937	Missense_Mutation	NA	F367C	0.55
READ	chrX	16852067	Missense_Mutation	NA	R340H	0.85
READ	chrX	16852577	Missense_Mutation	NA	E313K	0.87
SARC	chrX	16857686	Missense_Mutation	novel	D169Y	0.6
SARC	chrX	16857671	Missense_Mutation	novel	G174R	0.09
SKCM	chrX	16852571	Missense_Mutation	NA	H315Y	0.12
STAD	chrX	16858775	Missense_Mutation	NA	R128C	0.57
STAD	chrX	16852803	Silent	NA	C277C	0.38
STAD	chrX	16852079	Missense_Mutation	NA	G336D	0.11
STAD	chrX	16858743	Silent	NA	I138I	0.91
STAD	chrX	16853006	Intron	novel		1
STAD	chrX	16853590	Intron	novel		0.6
STAD	chrX	16869159	Missense_Mutation	novel	N26K	0.22
STAD	chrX	16852808	Missense_Mutation	NA	N276H	0.24
STAD	chrX	16852824	Silent	rs777081130	A270A	0.34
STAD	chrX	16853590	Intron	novel		0.62
STAD	chrX	16853688	Missense_Mutation	novel	L251R	0.41
STAD	chrX	16862995	Silent	novel	D89D	0.05
STAD	chrX	16853590	Intron	novel		0.6
STAD	chrX	16852915	Intron	novel		0.21
UCEC	chrX	16845021	3'UTR	novel		0.34
UCEC	chrX	16869212	Missense_Mutation	NA	D9Y	0.24
UCEC	chrX	16853545	Intron	novel		0.28
UCEC	chrX	16857690	Missense_Mutation	NA	N167K	0.17
UCEC	chrX	16858790	Missense_Mutation	NA	E123K	0.27
UCEC	chrX	16845058	Missense_Mutation	NA	E419K	0.04
UCEC	chrX	16852814	Missense_Mutation	NA	E274K	0.53
UCEC	chrX	16852573	Missense_Mutation	NA	S314Y	0.39
UCEC	chrX	16858790	Missense_Mutation	NA	E123K	0.39
UCEC	chrX	16852556	Missense_Mutation	novel	F320L	0.55
UCEC	chrX	16845076	Missense_Mutation	novel	S413A	0.31
UCEC	chrX	16857614	Silent	novel	L193L	0.13
UCEC	chrX	16852567	Missense_Mutation	novel	K316T	0.44
UCEC	chrX	16853819	Silent	rs140935002	N207N	0.39
UCEC	chrX	16857652	Missense_Mutation	NA	Y180C	0.42
UCEC	chrX	16853831	Silent	NA	L203L	0.1
UCEC	chrX	16853057	Intron	novel		0.43
UCEC	chrX	16853059	Intron	novel		0.33
UCEC	chrX	16869154	Missense_Mutation	NA	P28L	0.21
UCEC	chrX	16845058	Missense_Mutation	NA	E419K	0.22
UCEC	chrX	16852762	Missense_Mutation	novel	G291D	0.25
UCEC	chrX	16853815	Missense_Mutation	novel	G209R	0.18
UCEC	chrX	16853725	Missense_Mutation	novel	E239K	0.22
UCEC	chrX	16853590	Intron	novel		0.63
UCEC	chrX	16844726	3'UTR	novel		0.1
UCEC	chrX	16844966	3'UTR	novel		0.33
UCEC	chrX	16844720	3'UTR	novel		0.12
UCEC	chrX	16857639	Nonsense_Mutation	novel	W184*	0.38
UCEC	chrX	16853733	Missense_Mutation	NA	L236P	0.38
UCEC	chrX	16858802	Missense_Mutation	novel	K119Q	0.53
UCEC	chrX	16852577	Missense_Mutation	NA	E313K	0.26
UCEC	chrX	16844742	3'UTR	novel		0.11
UCEC	chrX	16852567	Missense_Mutation	novel	K316T	0.22
UCEC	chrX	16869666	Intron	novel		0.5
UCEC	chrX	16852560	Missense_Mutation	novel	E318D	0.34
UCEC	chrX	16870294	5'UTR	novel		0.4
UCEC	chrX	16853806	Missense_Mutation	novel	E212K	0.35
UCEC	chrX	16857621	Silent	novel	G190G	0.33
UCEC	chrX	16870148	5'UTR	novel		0.47
UCEC	chrX	16852558	Missense_Mutation	novel	I319N	0.04
UCEC	chrX	16852062	Missense_Mutation	NA	N342H	0.33
UCEC	chrX	16852573	Missense_Mutation	NA	S314Y	0.06
UCEC	chrX	16853661	Intron	novel		0.32
UCEC	chrX	16844972	3'UTR	novel		0.11
UCEC	chrX	16857640	Nonsense_Mutation	novel	W184*	0.34
UCEC	chrX	16863032	Missense_Mutation	novel	H77R	0.25
UCEC	chrX	16852677	Intron	novel		0.47
UCEC	chrX	16853806	Nonsense_Mutation	NA	E212*	0.4
UCEC	chrX	16852714	Intron	novel		0.29
UCEC	chrX	16870225	5'UTR	novel		0.39
UCEC	chrX	16853645	Intron	novel		0.17
UCEC	chrX	16853590	Intron	novel		0.24
UCEC	chrX	16844881	3'UTR	rs769447719		0.37
UCEC	chrX	16849247	Silent	novel	L365L	0.35
UCS	chrX	16852756	Missense_Mutation	NA	A293V	0.61

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PRAD	AMP	0.0346	0.00021979
READ	AMP	0.097	0.13718
SARC	AMP	0.2802	0.19108
THCA	DEL	0.002	0.21991

Survival Analysis

Cancer	P-value	Q-value
THYM	0.027	Kaplan-Meier Survival Analysis
ACC	0.04	Kaplan-Meier Survival Analysis
LUSC	0.012	Kaplan-Meier Survival Analysis
ESCA	0.00082	Kaplan-Meier Survival Analysis
KIRP	0.0018	Kaplan-Meier Survival Analysis
CESC	0.037	Kaplan-Meier Survival Analysis
KICH	0.024	Kaplan-Meier Survival Analysis
UCEC	0.01	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.0042	Kaplan-Meier Survival Analysis
THCA	0.025	Kaplan-Meier Survival Analysis
LUAD	0.01	Kaplan-Meier Survival Analysis
OV	0.043	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000102054 (Gene tree)
Gene ID: 5931
Gene Symbol: RBBP7
Alias: RbAp46
Full Name: RB binding protein 7, chromatin remodeling factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 31,160 bases
Position: chrX:16,839,283-16,870,442
Accession: 9890
RBP type: non-canonical RBP
Summary: This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30637779	Long-Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor-Specific Isoforms.	Hepatology	2019 Jan 13	Chen H	doi: 10.1002/hep.30500

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000493145	RBBP7-212	212	-	ENSP00000417507	37 (aa)	-	C9JAJ9
ENST00000465244	RBBP7-208	4031	-	-	- (aa)	-	-
ENST00000380087	RBBP7-203	2333	-	ENSP00000369427	425 (aa)	-	Q16576
ENST00000380084	RBBP7-202	2036	-	ENSP00000369424	469 (aa)	-	Q16576
ENST00000404022	RBBP7-204	1904	-	ENSP00000386068	416 (aa)	-	E9PC52
ENST00000416035	RBBP7-205	857	-	ENSP00000392714	285 (aa)	-	Q5JP01
ENST00000468092	RBBP7-209	630	-	ENSP00000417791	67 (aa)	-	C9J7L0
ENST00000425696	RBBP7-206	373	-	ENSP00000415747	85 (aa)	-	Q5JNZ6
ENST00000330735	RBBP7-201	858	-	-	- (aa)	-	-
ENST00000486166	RBBP7-211	1535	-	-	- (aa)	-	-
ENST00000444437	RBBP7-207	763	-	ENSP00000402796	175 (aa)	-	Q5JP02
ENST00000481586	RBBP7-210	503	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000102054's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102054's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000102054	RBBP7	100	78.947	WBGene00003036	lin-53	99	69.976	Caenorhabditis_elegans
ENSG00000102054	RBBP7	100	100.000	ENSMUSG00000031353	Rbbp7	100	99.765	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0003723	RNA binding	-	IEA	Function
GO:0005515	protein binding	7503932.9150135.18571423.19497860.19703393.19862764.21258344.22720776.23752268.25150861.26496610.27705803.28179136.	IPI	Function
GO:0005634	nucleus	16791210.	HDA	Component
GO:0005634	nucleus	22720776.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006260	DNA replication	-	IEA	Process
GO:0007275	multicellular organism development	7503932.	TAS	Process
GO:0008283	cell proliferation	7503932.	TAS	Process
GO:0016581	NuRD complex	19644445.22926524.	IDA	Component
GO:0030308	negative regulation of cell growth	9765217.	IDA	Process
GO:0034080	CENP-A containing nucleosome assembly	-	TAS	Process
GO:0035098	ESC/E(Z) complex	20075857.23104054.23273982.	IDA	Component
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0045814	negative regulation of gene expression, epigenetic	-	TAS	Process
GO:0048545	response to steroid hormone	-	IEA	Process
GO:0070317	negative regulation of G0 to G1 transition	-	TAS	Process
GO:0070370	cellular heat acclimation	7503932.	IDA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.