EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
COAD	chrX	48831216	3'UTR	rs781994116		0.24
COAD	chrX	48831189	3'UTR	novel		0.29
LUAD	chrX	48832222	Silent	novel	A78A	0.47
STAD	chrX	48831276	Missense_Mutation	novel	R256H	0.19
UCEC	chrX	48831276	Missense_Mutation	novel	R256H	0.47
UCEC	chrX	48831307	Missense_Mutation	novel	E246K	0.29
UCEC	chrX	48831400	Missense_Mutation	novel	P215S	0.33
UCEC	chrX	48831173	3'UTR	novel		0.57
UCEC	chrX	48831250	3'UTR	novel		0.46
UCEC	chrX	48831276	Missense_Mutation	novel	R256H	0.28

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
OV	AMP	0.2142	8.1018e-09
SARC	AMP	0.2918	0.19108
THCA	DEL	0.002	0.21991

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.043	Kaplan-Meier Survival Analysis
SARC	0.037	Kaplan-Meier Survival Analysis
MESO	0.031	Kaplan-Meier Survival Analysis
HNSC	0.034	Kaplan-Meier Survival Analysis
PRAD	0.019	Kaplan-Meier Survival Analysis
BRCA	0.036	Kaplan-Meier Survival Analysis
KIRP	0.026	Kaplan-Meier Survival Analysis
PAAD	0.0001	Kaplan-Meier Survival Analysis
UCEC	0.0019	Kaplan-Meier Survival Analysis
LIHC	0.036	Kaplan-Meier Survival Analysis
DLBC	0.021	Kaplan-Meier Survival Analysis
LGG	0.0014	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000102109 (Gene tree)
Gene ID: 27344
Gene Symbol: PCSK1N
Alias: SAAS|SgVIII|SCG8|proSAAS|PEN|BigLEN
Full Name: proprotein convertase subtilisin/kexin type 1 inhibitor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 4,547 bases
Position: chrX:48,831,092-48,835,638
Accession: 17301
RBP type: canonical RBP
Summary: The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000218230	ProSAAS	PF07259.12	2e-102	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23342162	Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain.	PLoS One	2013	Xie Q	doi: 10.1371/journal.pone.0054507

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000611033	PCSK1N-202	392	-	-	- (aa)	-	-
ENST00000218230	PCSK1N-201	1050	-	ENSP00000218230	260 (aa)	-	Q9UHG2

Gene Model

Click here to download ENSG00000102109's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102109's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000102109	PCSK1N	100	96.154	ENSANAG00000031176	PCSK1N	100	96.154	Aotus_nancymaae
ENSG00000102109	PCSK1N	99	87.645	ENSBTAG00000013250	PCSK1N	85	87.645	Bos_taurus
ENSG00000102109	PCSK1N	100	96.154	ENSCJAG00000047969	PCSK1N	100	96.154	Callithrix_jacchus
ENSG00000102109	PCSK1N	100	88.846	ENSCAFG00000015657	PCSK1N	100	88.846	Canis_familiaris
ENSG00000102109	PCSK1N	100	88.846	ENSCAFG00020020325	PCSK1N	100	88.846	Canis_lupus_dingo
ENSG00000102109	PCSK1N	99	87.259	ENSCHIG00000016734	PCSK1N	100	85.328	Capra_hircus
ENSG00000102109	PCSK1N	100	61.923	ENSTSYG00000030484	PCSK1N	100	59.387	Carlito_syrichta
ENSG00000102109	PCSK1N	95	83.468	ENSCPOG00000007567	PCSK1N	100	83.142	Cavia_porcellus
ENSG00000102109	PCSK1N	100	95.000	ENSCCAG00000032016	PCSK1N	100	95.000	Cebus_capucinus
ENSG00000102109	PCSK1N	100	97.701	ENSCATG00000036843	PCSK1N	100	97.701	Cercocebus_atys
ENSG00000102109	PCSK1N	58	83.051	ENSCLAG00000003392	PCSK1N	100	79.817	Chinchilla_lanigera
ENSG00000102109	PCSK1N	100	97.692	ENSCSAG00000013181	PCSK1N	100	97.692	Chlorocebus_sabaeus
ENSG00000102109	PCSK1N	77	93.750	ENSCANG00000033540	PCSK1N	91	95.918	Colobus_angolensis_palliatus
ENSG00000102109	PCSK1N	100	85.769	ENSCGRG00001013577	Pcsk1n	100	85.769	Cricetulus_griseus_chok1gshd
ENSG00000102109	PCSK1N	99	86.047	ENSDNOG00000045077	PCSK1N	99	87.209	Dasypus_novemcinctus
ENSG00000102109	PCSK1N	100	86.154	ENSDORG00000007957	Pcsk1n	100	86.154	Dipodomys_ordii
ENSG00000102109	PCSK1N	93	84.298	ENSEASG00005019237	PCSK1N	86	90.090	Equus_asinus_asinus
ENSG00000102109	PCSK1N	100	91.154	ENSECAG00000038828	PCSK1N	100	91.154	Equus_caballus
ENSG00000102109	PCSK1N	75	77.551	ENSEEUG00000013069	PCSK1N	100	82.143	Erinaceus_europaeus
ENSG00000102109	PCSK1N	100	87.692	ENSFCAG00000011223	PCSK1N	100	87.692	Felis_catus
ENSG00000102109	PCSK1N	100	99.231	ENSGGOG00000004538	PCSK1N	100	99.231	Gorilla_gorilla
ENSG00000102109	PCSK1N	95	85.141	ENSHGLG00000002975	PCSK1N	100	84.733	Heterocephalus_glaber_female
ENSG00000102109	PCSK1N	100	88.123	ENSSTOG00000025546	PCSK1N	100	87.739	Ictidomys_tridecemlineatus
ENSG00000102109	PCSK1N	100	85.115	ENSJJAG00000000165	Pcsk1n	100	85.115	Jaculus_jaculus
ENSG00000102109	PCSK1N	100	69.847	ENSLAFG00000030200	PCSK1N	100	69.084	Loxodonta_africana
ENSG00000102109	PCSK1N	86	97.321	ENSMFAG00000039428	PCSK1N	85	97.321	Macaca_fascicularis
ENSG00000102109	PCSK1N	88	97.817	ENSMMUG00000016469	PCSK1N	96	97.321	Macaca_mulatta
ENSG00000102109	PCSK1N	100	97.318	ENSMNEG00000035990	PCSK1N	100	97.318	Macaca_nemestrina
ENSG00000102109	PCSK1N	100	85.000	ENSMAUG00000015797	Pcsk1n	100	85.000	Mesocricetus_auratus
ENSG00000102109	PCSK1N	100	86.923	ENSMICG00000030219	PCSK1N	100	86.923	Microcebus_murinus
ENSG00000102109	PCSK1N	100	83.077	ENSMOCG00000016403	Pcsk1n	100	83.077	Microtus_ochrogaster
ENSG00000102109	PCSK1N	100	81.923	MGP_CAROLIEiJ_G0032906	Pcsk1n	100	83.846	Mus_caroli
ENSG00000102109	PCSK1N	100	81.538	ENSMUSG00000039278	Pcsk1n	100	83.462	Mus_musculus
ENSG00000102109	PCSK1N	100	81.538	MGP_PahariEiJ_G0031455	Pcsk1n	100	83.462	Mus_pahari
ENSG00000102109	PCSK1N	100	81.154	MGP_SPRETEiJ_G0034055	Pcsk1n	100	83.077	Mus_spretus
ENSG00000102109	PCSK1N	100	85.385	ENSMPUG00000013669	PCSK1N	100	85.385	Mustela_putorius_furo
ENSG00000102109	PCSK1N	74	75.879	ENSMLUG00000009125	PCSK1N	100	73.737	Myotis_lucifugus
ENSG00000102109	PCSK1N	99	85.769	ENSNGAG00000014688	Pcsk1n	99	85.769	Nannospalax_galili
ENSG00000102109	PCSK1N	100	98.077	ENSNLEG00000007899	PCSK1N	100	98.077	Nomascus_leucogenys
ENSG00000102109	PCSK1N	91	80.508	ENSOPRG00000012443	PCSK1N	99	80.426	Ochotona_princeps
ENSG00000102109	PCSK1N	100	84.291	ENSODEG00000010528	PCSK1N	100	84.291	Octodon_degus
ENSG00000102109	PCSK1N	90	78.632	ENSOCUG00000009021	PCSK1N	100	77.308	Oryctolagus_cuniculus
ENSG00000102109	PCSK1N	100	88.462	ENSOGAG00000034785	PCSK1N	100	88.462	Otolemur_garnettii
ENSG00000102109	PCSK1N	85	86.486	ENSOARG00000011670	PCSK1N	100	86.486	Ovis_aries
ENSG00000102109	PCSK1N	85	99.550	ENSPPAG00000034344	PCSK1N	100	99.550	Pan_paniscus
ENSG00000102109	PCSK1N	100	83.462	ENSPPRG00000010202	PCSK1N	100	86.154	Panthera_pardus
ENSG00000102109	PCSK1N	100	100.000	ENSPTRG00000049734	PCSK1N	100	100.000	Pan_troglodytes
ENSG00000102109	PCSK1N	100	97.318	ENSPANG00000015256	PCSK1N	100	97.318	Papio_anubis
ENSG00000102109	PCSK1N	100	86.538	ENSPEMG00000017215	Pcsk1n	100	86.538	Peromyscus_maniculatus_bairdii
ENSG00000102109	PCSK1N	100	99.231	ENSPPYG00000020322	PCSK1N	100	99.231	Pongo_abelii
ENSG00000102109	PCSK1N	100	91.154	ENSPCOG00000012912	PCSK1N	100	91.154	Propithecus_coquereli
ENSG00000102109	PCSK1N	100	83.846	ENSPVAG00000007642	PCSK1N	100	83.846	Pteropus_vampyrus
ENSG00000102109	PCSK1N	100	84.231	ENSRNOG00000007112	Pcsk1n	100	84.231	Rattus_norvegicus
ENSG00000102109	PCSK1N	100	84.231	ENSRNOG00000046021	LOC108348172	100	84.231	Rattus_norvegicus
ENSG00000102109	PCSK1N	89	92.672	ENSRBIG00000033130	PCSK1N	99	92.672	Rhinopithecus_bieti
ENSG00000102109	PCSK1N	85	97.297	ENSRROG00000042291	PCSK1N	95	97.297	Rhinopithecus_roxellana
ENSG00000102109	PCSK1N	100	96.538	ENSSBOG00000035004	PCSK1N	100	96.538	Saimiri_boliviensis_boliviensis
ENSG00000102109	PCSK1N	99	88.803	ENSSSCG00000021328	PCSK1N	100	88.803	Sus_scrofa
ENSG00000102109	PCSK1N	67	87.356	ENSTBEG00000011240	PCSK1N	71	89.655	Tupaia_belangeri
ENSG00000102109	PCSK1N	85	89.140	ENSTTRG00000004727	PCSK1N	100	89.140	Tursiops_truncatus
ENSG00000102109	PCSK1N	86	66.368	ENSVVUG00000017773	PCSK1N	70	66.368	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002021	response to dietary excess	-	IEA	Process
GO:0004866	endopeptidase inhibitor activity	21873635.	IBA	Function
GO:0004867	serine-type endopeptidase inhibitor activity	-	IEA	Function
GO:0005102	signaling receptor binding	10632593.	TAS	Function
GO:0005615	extracellular space	21873635.	IBA	Component
GO:0005802	trans-Golgi network	-	IEA	Component
GO:0007218	neuropeptide signaling pathway	-	IEA	Process
GO:0009409	response to cold	-	IEA	Process
GO:0010951	negative regulation of endopeptidase activity	-	IEA	Process
GO:0016486	peptide hormone processing	-	IEA	Process
GO:0030141	secretory granule	-	IEA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.