EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20068185Characterization of phosphoglycerate kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer progression.Cancer Res2010 Jan 15Wang Jdoi: 10.1158/0008-5472.CAN-09-2863
18603805PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells.Biosci Biotechnol Biochem2008 JulJang CH-
25867275Phosphoglycerate kinase-1 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in breast cancer.Br J Cancer2015 Apr 14Sun Sdoi: 10.1038/bjc.2015.114
30537744PGK1 is a Potential Survival Biomarker and Invasion Promoter by Regulating the HIF-1α-Mediated Epithelial-Mesenchymal Transition Process in Breast Cancer.Cell Physiol Biochem2018Fu Ddoi: 10.1159/000495900
26942675Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.Mol Cell2016 Mar 3Li Xdoi: 10.1016/j.molcel.2016.02.009.
21780947PPARγ disease gene network and identification of therapeutic targets for prostate cancer.J Drug Target2011 NovVenkatachalam Gdoi: 10.3109/1061186X.2011.568062
23727790Phosphoglycerate kinase 1 as a promoter of metastasis in colon cancer.Int J Oncol2013 AugAhmad SSdoi: 10.3892/ijo.2013.1971
23130662Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPARγ in breast cancer pathophysiology.J Drug Target2013 FebShashni Bdoi: 10.3109/1061186X.2012.736998
2845796817beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation.J Steroid Biochem Mol Biol2017 JulXu Ddoi: 10.1016/j.jsbmb.2017.04.009
28923857MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway.Cancer Res2017 Nov 1Yu Tdoi: 10.1158/0008-5472.CAN-17-0671
28763863[Influence of phosphoglycerate kinase 1 on metastasis and invasion of hepatoma cells and prognosis of liver cancer].Zhonghua Gan Zang Bing Za Zhi2017 Jun 20Zhang Ldoi: 10.3760/cma.j.issn.1007-3418.2017.06.011.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchrX78118059Missense_MutationnovelV177E0.29
BLCAchrX78118060SilentnovelV177V0.29
BLCAchrX78117380SilentNAV162V0.1
BLCAchrX78122947Missense_MutationnovelE252K0.11
BRCAchrX78118099Missense_MutationNAM190I0.38
BRCAchrX78122918Missense_MutationNAF242S0.37
BRCAchrX78113894SilentNAL89L0.08
BRCAchrX781260503'UTRnovel0.31
BRCAchrX78118128Missense_MutationNAA200V0.36
BRCAchrX78104351Missense_MutationNAS4C0.12
BRCAchrX781260313'UTRnovel0.45
BRCAchrX781258973'UTRnovel0.05
BRCAchrX78123315Missense_MutationNAD293H0.24
CESCchrX781259913'UTRNA0.37
CESCchrX78118096SilentNAL189L0.07
CESCchrX78114131Missense_MutationnovelG130W0.16
CESCchrX781258633'UTRnovel0.1
CESCchrX781043185'UTRrs7820215000.21
CESCchrX78113837Silentrs782224294V70V0.44
CESCchrX78122991IntronNA0.39
CESCchrX781260093'UTRnovel0.09
CESCchrX781042345'UTRnovel0.19
COADchrX78109908Missense_Mutationrs141397576N36T0.36
COADchrX78114108Missense_MutationnovelL122P0.05
COADchrX78123240Missense_MutationNAD268Y0.38
COADchrX78124998Missense_MutationNAA354V0.2
COADchrX78123302SilentNAT288T0.28
COADchrX78125791Splice_RegionNAG405G0.28
COADchrX781042535'UTRnovel0.21
COADchrX781260823'UTRnovel0.33
ESCAchrX781260813'UTRnovel0.67
ESCAchrX781042975'UTRnovel0.28
ESCAchrX781042815'UTRrs1929363900.67
GBMchrX78125423Missense_MutationnovelE404V0.1
GBMchrX78114028Missense_MutationnovelF95L0.06
GBMchrX781259143'UTRnovel0.14
GBMchrX78117362Missense_MutationnovelK156N0.1
GBMchrX78117363SilentnovelL157L0.1
HNSCchrX78109897Missense_MutationnovelN32K0.09
HNSCchrX78125367SilentnovelT385T0.68
HNSCchrX78109917Frame_Shift_Delnovel0.08
HNSCchrX781042935'UTRnovel0.21
HNSCchrX78109870SilentnovelV23V0.37
KIRCchrX78114086Missense_MutationNAS115T0.53
KIRCchrX78124899Missense_MutationNAS321N0.1
KIRCchrX781042665'UTRnovel0.09
KIRCchrX78118118Missense_MutationNAF197I0.57
LAMLchrX78118080Frame_Shift_InsnovelG187Wfs*310.12
LGGchrX78124998Missense_MutationNAA354V0.14
LGGchrX78114116Missense_MutationnovelH125N0.17
LIHCchrX78104376SilentnovelL12L0.56
LIHCchrX781259903'UTRnovel0.77
LUADchrX78109918Splice_SitenovelX39_splice0.13
LUADchrX781043055'UTRnovel0.07
LUADchrX78118171Splice_SitenovelX214_splice0.12
LUADchrX78125818Silentrs781803907L414L0.12
LUADchrX78118168Splice_RegionnovelG213G0.23
LUADchrX78118171Splice_SitenovelX214_splice0.17
LUADchrX781260103'UTRnovel0.4
LUADchrX78124929Missense_MutationnovelA331V0.25
LUADchrX78125012Missense_MutationnovelV359L0.78
LUADchrX78117374SilentnovelV160V0.6
LUADchrX78122950Splice_SitenovelX252_splice0.15
LUADchrX78124952Missense_MutationNAP339T0.07
LUSCchrX781260053'UTRnovel0.18
LUSCchrX78118113Missense_MutationNAN195S0.14
LUSCchrX78124922Missense_MutationnovelT329P0.61
LUSCchrX781042775'UTRnovel0.3
OVchrX78125023SilentnovelA362A0.06
OVchrX78125025Missense_MutationnovelT363I0.07
OVchrX78125353Missense_MutationnovelA381T0.34
OVchrX78122877Frame_Shift_DelnovelD229Tfs*60.05
OVchrX78118121Missense_MutationnovelA198T0.26
OVchrX78113747Missense_MutationNAI40M0.18
PAADchrX78114035Missense_MutationnovelD98Y0.08
PAADchrX78114153Missense_MutationnovelG137E0.2
READchrX78124886Missense_MutationnovelG317S0.11
READchrX78125030Missense_MutationnovelR365G0.04
READchrX78118113Missense_MutationNAN195S0.18
READchrX78123249Missense_MutationNAS271P0.47
SKCMchrX781260343'UTRnovel0.38
SKCMchrX781258423'UTRnovel0.23
SKCMchrX78114150Missense_MutationNAS136F0.37
SKCMchrX78114058SilentnovelE105E0.81
SKCMchrX78125367Silentrs782504246T385T0.17
SKCMchrX78118142Missense_MutationNAE205K0.31
SKCMchrX78123288Missense_MutationNAV284L0.27
STADchrX781260103'UTRnovel0.18
STADchrX78124902Missense_MutationNAK322R0.15
STADchrX78125802Missense_MutationNAP409H0.1
STADchrX78104366Missense_MutationNAL9R0.5
STADchrX78123359SilentNAI307I0.64
STADchrX78123232Missense_MutationnovelI265T0.08
STADchrX78123233SilentnovelI265I0.1
STADchrX78114107Missense_MutationNAL122I0.1
STADchrX78117320Silentrs201516932A142A0.07
THCAchrX781260493'UTRnovel0.13
THYMchrX781260423'UTRnovel0.27
UCECchrX78117394Missense_MutationNAG167D0.33
UCECchrX78114155Missense_MutationnovelN138D0.06
UCECchrX781260243'UTRnovel0.19
UCECchrX78114146Missense_MutationnovelA135T0.35
UCECchrX781042805'UTRnovel0.38
UCECchrX78123210Missense_MutationnovelF258V0.12
UCECchrX78123202Missense_MutationnovelT255N0.41
UCECchrX781259263'UTRnovel0.41
UCECchrX78109882SilentnovelV27V0.43
UCECchrX78117324Missense_MutationNAP144S0.36
UCECchrX78125363Missense_MutationnovelN384T0.05
UCECchrX781260663'UTRnovel0.1
UCECchrX78113798Silentrs78165041S57S0.45
UCECchrX78114035Missense_MutationNAD98N0.44
UCECchrX78122897Missense_MutationnovelI235N0.38
UCECchrX781258413'UTRrs2015970740.39
UCECchrX78125427Splice_SitenovelX405_splice0.35
UCECchrX78125342Missense_MutationnovelA377V0.23
UCECchrX781042535'UTRnovel0.2
UCECchrX78124913Missense_MutationNAE326K0.49
UCECchrX78104398Missense_MutationnovelV20I0.37
UCECchrX78104379SilentnovelD13D0.48
UCECchrX78114064SilentnovelA107A0.34
UCECchrX78124972Nonsense_MutationnovelW345*0.38
UCECchrX78104407Splice_SitenovelX22_splice0.52
UCECchrX78118050Splice_SiteNAX174_splice0.33
UCECchrX78125417Missense_MutationnovelL402P0.32
UCECchrX781261123'UTRnovel0.25
UCECchrX781258653'UTRnovel0.02
UCECchrX78114143Missense_MutationnovelD134Y0.12
UCECchrX781261893'UTRnovel0.25
UCECchrX78113824Missense_MutationnovelR66Q0.47
UCECchrX78123240Missense_MutationNAD268Y0.19
UCECchrX78125028Missense_MutationnovelS364Y0.36
UCECchrX781259673'UTRnovel0.24
UCECchrX781042765'UTRnovel0.83
UCECchrX78118126Missense_MutationnovelK199N0.39
UCECchrX781260393'UTRnovel0.45
UCECchrX781260453'UTRnovel0.49
UCECchrX78104406Splice_SitenovelX22_splice0.22
UCECchrX78124902Missense_MutationNAK322T0.27
UCECchrX781260663'UTRnovel0.15
UCECchrX78125816Missense_MutationnovelL414I0.08
UCECchrX781042585'UTRNA0.3
UCECchrX781042815'UTRrs1929363900.44
UCECchrX78114111Missense_MutationnovelR123H0.4
UCECchrX781260213'UTRnovel0.17
UCECchrX78124966SilentnovelF343F0.29
UCECchrX781262143'UTRnovel0.67
UCECchrX78104364SilentnovelT8T0.21
UCECchrX78114064SilentnovelA107A0.05
UCECchrX78123339Missense_MutationNAA301S0.17
UCECchrX781042745'UTRnovel0.43
UCECchrX78104374SilentnovelL12L0.34
UCECchrX78114063Missense_MutationnovelA107V0.47

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
THCADEL00.21991

Survival Analysis
CancerP-value Q-value
KIRC0.00033

Kaplan-Meier Survival Analysis

SARC0.00048

Kaplan-Meier Survival Analysis

HNSC0.0001

Kaplan-Meier Survival Analysis

PRAD0.035

Kaplan-Meier Survival Analysis

BRCA0.0001

Kaplan-Meier Survival Analysis

ESCA0.0007

Kaplan-Meier Survival Analysis

PAAD0.0087

Kaplan-Meier Survival Analysis

CESC0.00023

Kaplan-Meier Survival Analysis

LAML0.017

Kaplan-Meier Survival Analysis

KICH0.025

Kaplan-Meier Survival Analysis

LIHC0.00013

Kaplan-Meier Survival Analysis

LUAD0.016

Kaplan-Meier Survival Analysis

UVM0.036

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000102144 (Gene tree)
Gene ID
5230
Gene Symbol
PGK1
Alias
N
Full Name
phosphoglycerate kinase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
218,558 bases
Position
chrX:77,910,739-78,129,296
Accession
8896
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21080034Proteomic analysis of cisplatin resistance in human ovarian cancer using 2-DE method.Mol Cell Biochem2011 FebGong Fdoi: 10.1007/s11010-010-0648-6
21857920Validation of endogenous control genes for gene expression studies on human ocular surface epithelium.PLoS One2011Kulkarni Bdoi: 10.1371/journal.pone.0022301
25573171Identification of suitable reference genes for gene expression studies using quantitative polymerase chain reaction in lung cancer in vitro.Mol Med Rep2015 MayAli Hdoi: 10.3892/mmr.2015.3159
28134789Mrpl10 and Tbp Are Suitable Reference Genes for Peripheral Nerve Crush Injury.Int J Mol Sci2017 Jan 27Wang Ydoi: 10.3390/ijms18020263.
26393896Identification of Valid Housekeeping Genes for Real-Time Quantitative PCR Analysis of Collapsed Lung Tissues of Neonatal Somatic Cell Nuclear Transfer-Derived Cattle.Cell Reprogram2015 OctLiu Ydoi: 10.1089/cell.2015.0024.
30942461Identification of suitable reference genes for gene expression studies in rat skeletal muscle following sciatic nerve crush injury.Mol Med Rep2019 MayWang Xdoi: 10.3892/mmr.2019.10102
30982460HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.Autophagy2019 Apr 14:1-18Neubert Pdoi: 10.1080/15548627.2019.1596483
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000373316PGK1-2014887-ENSP00000362413417 (aa)-P00558
ENST00000644362PGK1-2062405-ENSP00000496140389 (aa)-P00558
ENST00000477335PGK1-204353--- (aa)--
ENST00000474281PGK1-202307--- (aa)--
ENST00000491291PGK1-205702--- (aa)--
ENST00000476531PGK1-203960--- (aa)--
Gene Model
Click here to download ENSG00000102144's gene model file
Pathways
Pathway IDPathway NameSource
hsa00010Glycolysis / GluconeogenesisKEGG
hsa01100Metabolic pathwaysKEGG
hsa01200Carbon metabolismKEGG
hsa01230Biosynthesis of amino acidsKEGG
hsa04066HIF-1 signaling pathwayKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102144's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000102144PGK19973.385WBGene00020185pgk-19972.771Caenorhabditis_elegans
ENSG00000102144PGK110097.842ENSMUSG00000062070Pgk110097.842Mus_musculus
ENSG00000102144PGK19965.783YCR012W9965.783Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004618phosphoglycerate kinase activity21873635.IBAFunction
GO:0004618phosphoglycerate kinase activity7391028.IMPFunction
GO:0004618phosphoglycerate kinase activity-ISSFunction
GO:0005515protein binding20392205.26356530.IPIFunction
GO:0005524ATP binding21873635.IBAFunction
GO:0005524ATP binding-ISSFunction
GO:0005615extracellular space11130727.IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0006094gluconeogenesis21873635.IBAProcess
GO:0006094gluconeogenesis-TASProcess
GO:0006096glycolytic process21873635.IBAProcess
GO:0006096glycolytic process7391028.IMPProcess
GO:0016020membrane19946888.HDAComponent
GO:0016310phosphorylation-ISSProcess
GO:0016525negative regulation of angiogenesis11130727.IMPProcess
GO:0030855epithelial cell differentiation21492153.IEPProcess
GO:0031639plasminogen activation11130727.IMPProcess
GO:0043531ADP binding21873635.IBAFunction
GO:0045121membrane raft25204797.IDAComponent
GO:0047134protein-disulfide reductase activity11130727.IMPFunction
GO:0061621canonical glycolysis-TASProcess
GO:0070062extracellular exosome11487543.19199708.20458337.23533145.HDAComponent
GO:0071456cellular response to hypoxia11130727.IDAProcess
GO:1903862positive regulation of oxidative phosphorylation21873635.IBAProcess
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