EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20068185	Characterization of phosphoglycerate kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer progression.	Cancer Res	2010 Jan 15	Wang J	doi: 10.1158/0008-5472.CAN-09-2863
18603805	PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells.	Biosci Biotechnol Biochem	2008 Jul	Jang CH	-
25867275	Phosphoglycerate kinase-1 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in breast cancer.	Br J Cancer	2015 Apr 14	Sun S	doi: 10.1038/bjc.2015.114
30537744	PGK1 is a Potential Survival Biomarker and Invasion Promoter by Regulating the HIF-1α-Mediated Epithelial-Mesenchymal Transition Process in Breast Cancer.	Cell Physiol Biochem	2018	Fu D	doi: 10.1159/000495900
26942675	Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis.	Mol Cell	2016 Mar 3	Li X	doi: 10.1016/j.molcel.2016.02.009.
21780947	PPARγ disease gene network and identification of therapeutic targets for prostate cancer.	J Drug Target	2011 Nov	Venkatachalam G	doi: 10.3109/1061186X.2011.568062
23727790	Phosphoglycerate kinase 1 as a promoter of metastasis in colon cancer.	Int J Oncol	2013 Aug	Ahmad SS	doi: 10.3892/ijo.2013.1971
23130662	Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPARγ in breast cancer pathophysiology.	J Drug Target	2013 Feb	Shashni B	doi: 10.3109/1061186X.2012.736998
28457968	17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation.	J Steroid Biochem Mol Biol	2017 Jul	Xu D	doi: 10.1016/j.jsbmb.2017.04.009
28923857	MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway.	Cancer Res	2017 Nov 1	Yu T	doi: 10.1158/0008-5472.CAN-17-0671
28763863	[Influence of phosphoglycerate kinase 1 on metastasis and invasion of hepatoma cells and prognosis of liver cancer].	Zhonghua Gan Zang Bing Za Zhi	2017 Jun 20	Zhang L	doi: 10.3760/cma.j.issn.1007-3418.2017.06.011.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chrX	78118059	Missense_Mutation	novel	V177E	0.29
BLCA	chrX	78118060	Silent	novel	V177V	0.29
BLCA	chrX	78117380	Silent	NA	V162V	0.1
BLCA	chrX	78122947	Missense_Mutation	novel	E252K	0.11
BRCA	chrX	78118099	Missense_Mutation	NA	M190I	0.38
BRCA	chrX	78122918	Missense_Mutation	NA	F242S	0.37
BRCA	chrX	78113894	Silent	NA	L89L	0.08
BRCA	chrX	78126050	3'UTR	novel		0.31
BRCA	chrX	78118128	Missense_Mutation	NA	A200V	0.36
BRCA	chrX	78104351	Missense_Mutation	NA	S4C	0.12
BRCA	chrX	78126031	3'UTR	novel		0.45
BRCA	chrX	78125897	3'UTR	novel		0.05
BRCA	chrX	78123315	Missense_Mutation	NA	D293H	0.24
CESC	chrX	78125991	3'UTR	NA		0.37
CESC	chrX	78118096	Silent	NA	L189L	0.07
CESC	chrX	78114131	Missense_Mutation	novel	G130W	0.16
CESC	chrX	78125863	3'UTR	novel		0.1
CESC	chrX	78104318	5'UTR	rs782021500		0.21
CESC	chrX	78113837	Silent	rs782224294	V70V	0.44
CESC	chrX	78122991	Intron	NA		0.39
CESC	chrX	78126009	3'UTR	novel		0.09
CESC	chrX	78104234	5'UTR	novel		0.19
COAD	chrX	78109908	Missense_Mutation	rs141397576	N36T	0.36
COAD	chrX	78114108	Missense_Mutation	novel	L122P	0.05
COAD	chrX	78123240	Missense_Mutation	NA	D268Y	0.38
COAD	chrX	78124998	Missense_Mutation	NA	A354V	0.2
COAD	chrX	78123302	Silent	NA	T288T	0.28
COAD	chrX	78125791	Splice_Region	NA	G405G	0.28
COAD	chrX	78104253	5'UTR	novel		0.21
COAD	chrX	78126082	3'UTR	novel		0.33
ESCA	chrX	78126081	3'UTR	novel		0.67
ESCA	chrX	78104297	5'UTR	novel		0.28
ESCA	chrX	78104281	5'UTR	rs192936390		0.67
GBM	chrX	78125423	Missense_Mutation	novel	E404V	0.1
GBM	chrX	78114028	Missense_Mutation	novel	F95L	0.06
GBM	chrX	78125914	3'UTR	novel		0.14
GBM	chrX	78117362	Missense_Mutation	novel	K156N	0.1
GBM	chrX	78117363	Silent	novel	L157L	0.1
HNSC	chrX	78109897	Missense_Mutation	novel	N32K	0.09
HNSC	chrX	78125367	Silent	novel	T385T	0.68
HNSC	chrX	78109917	Frame_Shift_Del	novel		0.08
HNSC	chrX	78104293	5'UTR	novel		0.21
HNSC	chrX	78109870	Silent	novel	V23V	0.37
KIRC	chrX	78114086	Missense_Mutation	NA	S115T	0.53
KIRC	chrX	78124899	Missense_Mutation	NA	S321N	0.1
KIRC	chrX	78104266	5'UTR	novel		0.09
KIRC	chrX	78118118	Missense_Mutation	NA	F197I	0.57
LAML	chrX	78118080	Frame_Shift_Ins	novel	*G187Wfs31**	0.12
LGG	chrX	78124998	Missense_Mutation	NA	A354V	0.14
LGG	chrX	78114116	Missense_Mutation	novel	H125N	0.17
LIHC	chrX	78104376	Silent	novel	L12L	0.56
LIHC	chrX	78125990	3'UTR	novel		0.77
LUAD	chrX	78109918	Splice_Site	novel	X39_splice	0.13
LUAD	chrX	78104305	5'UTR	novel		0.07
LUAD	chrX	78118171	Splice_Site	novel	X214_splice	0.12
LUAD	chrX	78125818	Silent	rs781803907	L414L	0.12
LUAD	chrX	78118168	Splice_Region	novel	G213G	0.23
LUAD	chrX	78118171	Splice_Site	novel	X214_splice	0.17
LUAD	chrX	78126010	3'UTR	novel		0.4
LUAD	chrX	78124929	Missense_Mutation	novel	A331V	0.25
LUAD	chrX	78125012	Missense_Mutation	novel	V359L	0.78
LUAD	chrX	78117374	Silent	novel	V160V	0.6
LUAD	chrX	78122950	Splice_Site	novel	X252_splice	0.15
LUAD	chrX	78124952	Missense_Mutation	NA	P339T	0.07
LUSC	chrX	78126005	3'UTR	novel		0.18
LUSC	chrX	78118113	Missense_Mutation	NA	N195S	0.14
LUSC	chrX	78124922	Missense_Mutation	novel	T329P	0.61
LUSC	chrX	78104277	5'UTR	novel		0.3
OV	chrX	78125023	Silent	novel	A362A	0.06
OV	chrX	78125025	Missense_Mutation	novel	T363I	0.07
OV	chrX	78125353	Missense_Mutation	novel	A381T	0.34
OV	chrX	78122877	Frame_Shift_Del	novel	*D229Tfs6**	0.05
OV	chrX	78118121	Missense_Mutation	novel	A198T	0.26
OV	chrX	78113747	Missense_Mutation	NA	I40M	0.18
PAAD	chrX	78114035	Missense_Mutation	novel	D98Y	0.08
PAAD	chrX	78114153	Missense_Mutation	novel	G137E	0.2
READ	chrX	78124886	Missense_Mutation	novel	G317S	0.11
READ	chrX	78125030	Missense_Mutation	novel	R365G	0.04
READ	chrX	78118113	Missense_Mutation	NA	N195S	0.18
READ	chrX	78123249	Missense_Mutation	NA	S271P	0.47
SKCM	chrX	78126034	3'UTR	novel		0.38
SKCM	chrX	78125842	3'UTR	novel		0.23
SKCM	chrX	78114150	Missense_Mutation	NA	S136F	0.37
SKCM	chrX	78114058	Silent	novel	E105E	0.81
SKCM	chrX	78125367	Silent	rs782504246	T385T	0.17
SKCM	chrX	78118142	Missense_Mutation	NA	E205K	0.31
SKCM	chrX	78123288	Missense_Mutation	NA	V284L	0.27
STAD	chrX	78126010	3'UTR	novel		0.18
STAD	chrX	78124902	Missense_Mutation	NA	K322R	0.15
STAD	chrX	78125802	Missense_Mutation	NA	P409H	0.1
STAD	chrX	78104366	Missense_Mutation	NA	L9R	0.5
STAD	chrX	78123359	Silent	NA	I307I	0.64
STAD	chrX	78123232	Missense_Mutation	novel	I265T	0.08
STAD	chrX	78123233	Silent	novel	I265I	0.1
STAD	chrX	78114107	Missense_Mutation	NA	L122I	0.1
STAD	chrX	78117320	Silent	rs201516932	A142A	0.07
THCA	chrX	78126049	3'UTR	novel		0.13
THYM	chrX	78126042	3'UTR	novel		0.27
UCEC	chrX	78117394	Missense_Mutation	NA	G167D	0.33
UCEC	chrX	78114155	Missense_Mutation	novel	N138D	0.06
UCEC	chrX	78126024	3'UTR	novel		0.19
UCEC	chrX	78114146	Missense_Mutation	novel	A135T	0.35
UCEC	chrX	78104280	5'UTR	novel		0.38
UCEC	chrX	78123210	Missense_Mutation	novel	F258V	0.12
UCEC	chrX	78123202	Missense_Mutation	novel	T255N	0.41
UCEC	chrX	78125926	3'UTR	novel		0.41
UCEC	chrX	78109882	Silent	novel	V27V	0.43
UCEC	chrX	78117324	Missense_Mutation	NA	P144S	0.36
UCEC	chrX	78125363	Missense_Mutation	novel	N384T	0.05
UCEC	chrX	78126066	3'UTR	novel		0.1
UCEC	chrX	78113798	Silent	rs78165041	S57S	0.45
UCEC	chrX	78114035	Missense_Mutation	NA	D98N	0.44
UCEC	chrX	78122897	Missense_Mutation	novel	I235N	0.38
UCEC	chrX	78125841	3'UTR	rs201597074		0.39
UCEC	chrX	78125427	Splice_Site	novel	X405_splice	0.35
UCEC	chrX	78125342	Missense_Mutation	novel	A377V	0.23
UCEC	chrX	78104253	5'UTR	novel		0.2
UCEC	chrX	78124913	Missense_Mutation	NA	E326K	0.49
UCEC	chrX	78104398	Missense_Mutation	novel	V20I	0.37
UCEC	chrX	78104379	Silent	novel	D13D	0.48
UCEC	chrX	78114064	Silent	novel	A107A	0.34
UCEC	chrX	78124972	Nonsense_Mutation	novel	W345*	0.38
UCEC	chrX	78104407	Splice_Site	novel	X22_splice	0.52
UCEC	chrX	78118050	Splice_Site	NA	X174_splice	0.33
UCEC	chrX	78125417	Missense_Mutation	novel	L402P	0.32
UCEC	chrX	78126112	3'UTR	novel		0.25
UCEC	chrX	78125865	3'UTR	novel		0.02
UCEC	chrX	78114143	Missense_Mutation	novel	D134Y	0.12
UCEC	chrX	78126189	3'UTR	novel		0.25
UCEC	chrX	78113824	Missense_Mutation	novel	R66Q	0.47
UCEC	chrX	78123240	Missense_Mutation	NA	D268Y	0.19
UCEC	chrX	78125028	Missense_Mutation	novel	S364Y	0.36
UCEC	chrX	78125967	3'UTR	novel		0.24
UCEC	chrX	78104276	5'UTR	novel		0.83
UCEC	chrX	78118126	Missense_Mutation	novel	K199N	0.39
UCEC	chrX	78126039	3'UTR	novel		0.45
UCEC	chrX	78126045	3'UTR	novel		0.49
UCEC	chrX	78104406	Splice_Site	novel	X22_splice	0.22
UCEC	chrX	78124902	Missense_Mutation	NA	K322T	0.27
UCEC	chrX	78126066	3'UTR	novel		0.15
UCEC	chrX	78125816	Missense_Mutation	novel	L414I	0.08
UCEC	chrX	78104258	5'UTR	NA		0.3
UCEC	chrX	78104281	5'UTR	rs192936390		0.44
UCEC	chrX	78114111	Missense_Mutation	novel	R123H	0.4
UCEC	chrX	78126021	3'UTR	novel		0.17
UCEC	chrX	78124966	Silent	novel	F343F	0.29
UCEC	chrX	78126214	3'UTR	novel		0.67
UCEC	chrX	78104364	Silent	novel	T8T	0.21
UCEC	chrX	78114064	Silent	novel	A107A	0.05
UCEC	chrX	78123339	Missense_Mutation	NA	A301S	0.17
UCEC	chrX	78104274	5'UTR	novel		0.43
UCEC	chrX	78104374	Silent	novel	L12L	0.34
UCEC	chrX	78114063	Missense_Mutation	novel	A107V	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
THCA	DEL	0	0.21991

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00033	Kaplan-Meier Survival Analysis
SARC	0.00048	Kaplan-Meier Survival Analysis
HNSC	0.0001	Kaplan-Meier Survival Analysis
PRAD	0.035	Kaplan-Meier Survival Analysis
BRCA	0.0001	Kaplan-Meier Survival Analysis
ESCA	0.0007	Kaplan-Meier Survival Analysis
PAAD	0.0087	Kaplan-Meier Survival Analysis
CESC	0.00023	Kaplan-Meier Survival Analysis
LAML	0.017	Kaplan-Meier Survival Analysis
KICH	0.025	Kaplan-Meier Survival Analysis
LIHC	0.00013	Kaplan-Meier Survival Analysis
LUAD	0.016	Kaplan-Meier Survival Analysis
UVM	0.036	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000102144 (Gene tree)
Gene ID: 5230
Gene Symbol: PGK1
Alias: N
Full Name: phosphoglycerate kinase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 218,558 bases
Position: chrX:77,910,739-78,129,296
Accession: 8896
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21080034	Proteomic analysis of cisplatin resistance in human ovarian cancer using 2-DE method.	Mol Cell Biochem	2011 Feb	Gong F	doi: 10.1007/s11010-010-0648-6
21857920	Validation of endogenous control genes for gene expression studies on human ocular surface epithelium.	PLoS One	2011	Kulkarni B	doi: 10.1371/journal.pone.0022301
25573171	Identification of suitable reference genes for gene expression studies using quantitative polymerase chain reaction in lung cancer in vitro.	Mol Med Rep	2015 May	Ali H	doi: 10.3892/mmr.2015.3159
28134789	Mrpl10 and Tbp Are Suitable Reference Genes for Peripheral Nerve Crush Injury.	Int J Mol Sci	2017 Jan 27	Wang Y	doi: 10.3390/ijms18020263.
26393896	Identification of Valid Housekeeping Genes for Real-Time Quantitative PCR Analysis of Collapsed Lung Tissues of Neonatal Somatic Cell Nuclear Transfer-Derived Cattle.	Cell Reprogram	2015 Oct	Liu Y	doi: 10.1089/cell.2015.0024.
30942461	Identification of suitable reference genes for gene expression studies in rat skeletal muscle following sciatic nerve crush injury.	Mol Med Rep	2019 May	Wang X	doi: 10.3892/mmr.2019.10102
30982460	HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.	Autophagy	2019 Apr 14:1-18	Neubert P	doi: 10.1080/15548627.2019.1596483

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000373316	PGK1-201	4887	-	ENSP00000362413	417 (aa)	-	P00558
ENST00000644362	PGK1-206	2405	-	ENSP00000496140	389 (aa)	-	P00558
ENST00000477335	PGK1-204	353	-	-	- (aa)	-	-
ENST00000474281	PGK1-202	307	-	-	- (aa)	-	-
ENST00000491291	PGK1-205	702	-	-	- (aa)	-	-
ENST00000476531	PGK1-203	960	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000102144's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG
hsa04066	HIF-1 signaling pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102144's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000102144	PGK1	99	73.385	WBGene00020185	pgk-1	99	72.771	Caenorhabditis_elegans
ENSG00000102144	PGK1	100	97.842	ENSMUSG00000062070	Pgk1	100	97.842	Mus_musculus
ENSG00000102144	PGK1	99	65.783	YCR012W		99	65.783	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004618	phosphoglycerate kinase activity	21873635.	IBA	Function
GO:0004618	phosphoglycerate kinase activity	7391028.	IMP	Function
GO:0004618	phosphoglycerate kinase activity	-	ISS	Function
GO:0005515	protein binding	20392205.26356530.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	-	ISS	Function
GO:0005615	extracellular space	11130727.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006094	gluconeogenesis	21873635.	IBA	Process
GO:0006094	gluconeogenesis	-	TAS	Process
GO:0006096	glycolytic process	21873635.	IBA	Process
GO:0006096	glycolytic process	7391028.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016310	phosphorylation	-	ISS	Process
GO:0016525	negative regulation of angiogenesis	11130727.	IMP	Process
GO:0030855	epithelial cell differentiation	21492153.	IEP	Process
GO:0031639	plasminogen activation	11130727.	IMP	Process
GO:0043531	ADP binding	21873635.	IBA	Function
GO:0045121	membrane raft	25204797.	IDA	Component
GO:0047134	protein-disulfide reductase activity	11130727.	IMP	Function
GO:0061621	canonical glycolysis	-	TAS	Process
GO:0070062	extracellular exosome	11487543.19199708.20458337.23533145.	HDA	Component
GO:0071456	cellular response to hypoxia	11130727.	IDA	Process
GO:1903862	positive regulation of oxidative phosphorylation	21873635.	IBA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.