EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20217863	The effect of simvastatin on the proteome of detergent-resistant membrane domains: decreases of specific proteins previously related to cytoskeleton regulation, calcium homeostasis and cell fate.	Proteomics	2010 May	Ponce J	doi: 10.1002/pmic.200900055.
26884185	Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.	Proc Natl Acad Sci U S A	2016 Mar 1	Lissanu Deribe Y	doi: 10.1073/pnas.1513801113
25936522	Coronin 1A depletion protects endothelial cells from TNFα-induced apoptosis by modulating p38Beta expression and activation.	Cell Signal	2015 Sep	Kim GY	doi: 10.1016/j.cellsig.2015.04.012

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr16	30185410	Splice_Region	novel		0.5
BLCA	chr16	30187811	Silent	novel	I281I	0.12
BLCA	chr16	30187881	Intron	novel		0.28
BLCA	chr16	30188547	Missense_Mutation	rs757620393	A418T	0.59
BLCA	chr16	30188459	Silent	novel	L388L	0.21
BLCA	chr16	30186822	Missense_Mutation	novel	E110Q	0.16
BLCA	chr16	30186937	Missense_Mutation	novel	L148P	0.2
BLCA	chr16	30186938	Frame_Shift_Ins	novel	S149*	0.21
BLCA	chr16	30188387	Nonsense_Mutation	NA	Y364*	0.26
BLCA	chr16	30188245	Missense_Mutation	novel	R354Q	0.31
BLCA	chr16	30186647	Missense_Mutation	novel	P83L	0.37
BRCA	chr16	30186437	Intron	novel		0.24
BRCA	chr16	30186831	Missense_Mutation	NA	D113H	0.18
BRCA	chr16	30188111	Intron	novel		0.38
CESC	chr16	30187929	Intron	novel		0.54
CESC	chr16	30187431	Missense_Mutation	novel	V229A	0.07
CESC	chr16	30187734	Missense_Mutation	novel	E256Q	0.12
CESC	chr16	30186842	Silent	NA	L116L	0.24
CESC	chr16	30187519	Intron	novel		0.17
CESC	chr16	30187520	Intron	novel		0.17
CESC	chr16	30188108	Intron	novel		0.61
CESC	chr16	30188397	Missense_Mutation	novel	A368T	0.63
CESC	chr16	30186684	Silent	rs184262856	N95N	0.26
COAD	chr16	30185433	Intron	novel		0.41
COAD	chr16	30185371	Silent	rs536390638	S54S	0.33
COAD	chr16	30185271	Missense_Mutation	NA	A21V	0.32
COAD	chr16	30188288	Intron	novel		0.4
COAD	chr16	30185403	Missense_Mutation	novel	G65D	0.39
COAD	chr16	30187812	Missense_Mutation	NA	V282I	0.17
COAD	chr16	30188308	Intron	novel		0.43
COAD	chr16	30187673	Intron	novel		0.17
COAD	chr16	30187136	Missense_Mutation	novel	D183E	0.37
COAD	chr16	30187931	Intron	novel		0.29
COAD	chr16	30186435	Intron	novel		0.25
COAD	chr16	30186621	Silent	rs747607776	A74A	0.15
COAD	chr16	30188397	Missense_Mutation	novel	A368T	0.67
COAD	chr16	30186912	Missense_Mutation	NA	H140N	0.35
DLBC	chr16	30188471	Silent	novel	L392L	0.41
DLBC	chr16	30187142	Silent	rs745531321	S185S	0.22
DLBC	chr16	30188628	Intron	novel		0.29
ESCA	chr16	30187049	Silent	rs762370414	N154N	0.49
GBM	chr16	30187399	Silent	rs772017896	H218H	0.56
GBM	chr16	30187034	Splice_Region	novel		0.08
GBM	chr16	30186660	Silent	rs763085431	I87I	0.53
GBM	chr16	30187197	Missense_Mutation	rs752499984	E204K	0.29
GBM	chr16	30186999	Intron	novel		0.26
HNSC	chr16	30188195	Missense_Mutation	novel	F337L	0.09
HNSC	chr16	30186540	Intron	novel		0.17
HNSC	chr16	30188499	Missense_Mutation	rs150186033	R402W	0.39
KIRC	chr16	30187473	Missense_Mutation	NA	S243N	0.24
KIRP	chr16	30188107	Intron	novel		0.45
LGG	chr16	30187531	Intron	novel		0.38
LGG	chr16	30188443	Missense_Mutation	rs61736366	R383Q	0.1
LIHC	chr16	30188268	Intron	novel		0.42
LIHC	chr16	30187142	Silent	rs745531321	S185S	0.32
LUAD	chr16	30186684	Silent	rs184262856	N95N	0.19
LUAD	chr16	30187861	Intron	novel		0.28
LUAD	chr16	30187108	Missense_Mutation	NA	V174A	0.14
LUAD	chr16	30187082	Frame_Shift_Del	novel	*A166Pfs3**	0.15
LUAD	chr16	30188445	Missense_Mutation	NA	D384N	0.14
LUAD	chr16	30188297	Intron	novel		0.24
LUSC	chr16	30186831	Missense_Mutation	NA	D113H	0.07
OV	chr16	30187115	Silent	novel	P176P	0.16
OV	chr16	30187976	Missense_Mutation	NA	S299F	0.14
PAAD	chr16	30187035	Splice_Region	novel		0.09
READ	chr16	30185371	Silent	rs536390638	S54S	0.28
SKCM	chr16	30187404	Missense_Mutation	NA	G220E	0.41
SKCM	chr16	30187692	Intron	novel		0.48
SKCM	chr16	30186540	Intron	novel		0.24
SKCM	chr16	30188439	Missense_Mutation	novel	G382S	0.37
SKCM	chr16	30188504	Silent	NA	E403E	0.36
SKCM	chr16	30186821	Nonsense_Mutation	NA	W109*	0.53
SKCM	chr16	30186756	Intron	novel		0.38
SKCM	chr16	30188363	Splice_Region	rs752449610	S356S	0.19
SKCM	chr16	30186805	Intron	novel		0.32
SKCM	chr16	30188495	Silent	rs757666860	K400K	0.23
SKCM	chr16	30186720	Missense_Mutation	NA	M107I	0.43
SKCM	chr16	30186744	Intron	novel		0.46
SKCM	chr16	30185266	Silent	NA	A19A	0.18
SKCM	chr16	30185386	Silent	novel	F59F	0.41
SKCM	chr16	30188056	Missense_Mutation	novel	G326S	0.31
SKCM	chr16	30186579	Intron	novel		0.21
SKCM	chr16	30187983	Silent	NA	A301A	0.37
SKCM	chr16	30186758	Intron	novel		0.18
SKCM	chr16	30186831	Missense_Mutation	NA	D113N	0.1
SKCM	chr16	30188062	Missense_Mutation	novel	E328K	0.34
STAD	chr16	30188500	Missense_Mutation	NA	R402Q	0.29
STAD	chr16	30188369	Silent	NA	L358L	0.3
STAD	chr16	30186834	Frame_Shift_Del	novel	*G115Afs2**	0.27
STAD	chr16	30188404	Missense_Mutation	novel	P370H	0.05
STAD	chr16	30188399	Silent	novel	A368A	0.44
STAD	chr16	30188500	Missense_Mutation	NA	R402Q	0.29
STAD	chr16	30185228	Missense_Mutation	NA	R7C	0.29
STAD	chr16	30187812	Missense_Mutation	NA	V282I	0.26
STAD	chr16	30187035	Splice_Region	novel		0.67
STAD	chr16	30188408	Missense_Mutation	NA	D371E	0.39
STAD	chr16	30186708	Silent	NA	D103D	0.23
STAD	chr16	30188006	Missense_Mutation	NA	M309T	0.25
STAD	chr16	30187424	Missense_Mutation	NA	V227M	0.33
THCA	chr16	30186469	Intron	novel		0.17
UCEC	chr16	30188128	Intron	novel		0.36
UCEC	chr16	30188420	Silent	rs774230354	T375T	0.22
UCEC	chr16	30186620	Missense_Mutation	rs373022238	A74V	0.51
UCEC	chr16	30187187	Silent	novel	V200V	0.28
UCEC	chr16	30186620	Missense_Mutation	rs373022238	A74V	0.3
UCEC	chr16	30185267	Missense_Mutation	novel	K20E	0.17
UCEC	chr16	30188308	Intron	novel		0.5
UCEC	chr16	30186663	Silent	novel	A88A	0.06
UCEC	chr16	30188442	Missense_Mutation	NA	R383W	0.25
UCEC	chr16	30188426	Missense_Mutation	NA	E377D	0.2
UCEC	chr16	30185367	Missense_Mutation	novel	A53V	0.24
UCEC	chr16	30187104	Nonsense_Mutation	NA	E173*	0.23
UCEC	chr16	30185297	Missense_Mutation	rs775464405	V30I	0.52
UCEC	chr16	30186967	Intron	novel		0.35
UCEC	chr16	30186603	Silent	novel	G68G	0.4
UCEC	chr16	30185375	Missense_Mutation	NA	G56R	0.28
UCEC	chr16	30188363	Splice_Region	rs752449610	S356S	0.21
UCEC	chr16	30188307	Intron	novel		0.34
UCEC	chr16	30188082	Silent	rs377351892	I334I	0.36
UCEC	chr16	30188320	Intron	novel		0.34
UCEC	chr16	30186445	Intron	novel		0.4
UCEC	chr16	30186685	Missense_Mutation	rs756845489	V96I	0.28
UCEC	chr16	30187049	Silent	rs762370414	N154N	0.41
UCEC	chr16	30187811	Silent	rs199650298	I281I	0.38
UCEC	chr16	30188054	Missense_Mutation	novel	R325H	0.04
UCEC	chr16	30187081	Missense_Mutation	rs371653086	A165V	0.49
UCEC	chr16	30187599	Intron	novel		0.4
UCEC	chr16	30187450	Silent	novel	L235L	0.51
UCEC	chr16	30187218	Missense_Mutation	rs371818902	V211I	0.33
UCEC	chr16	30188535	Missense_Mutation	novel	R414C	0.25
UCEC	chr16	30186457	Intron	novel		0.35
UCEC	chr16	30188317	Intron	novel		0.49
UCEC	chr16	30186347	Intron	novel		0.6
UCEC	chr16	30187410	Missense_Mutation	novel	R222Q	0.34
UCEC	chr16	30187593	Intron	novel		0.39
UCEC	chr16	30187702	Intron	novel		0.19
UCEC	chr16	30188144	Intron	novel		0.25
UCEC	chr16	30188293	Intron	novel		0.36
UCEC	chr16	30186362	Intron	novel		0.36
UVM	chr16	30185457	Intron	novel		0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.0556	0.23475
LUAD	AMP	0.2461	0.20955

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0049	Kaplan-Meier Survival Analysis
KIRC	0.0054	Kaplan-Meier Survival Analysis
SARC	0.023	Kaplan-Meier Survival Analysis
HNSC	0.00038	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
BRCA	0.013	Kaplan-Meier Survival Analysis
ESCA	0.047	Kaplan-Meier Survival Analysis
CESC	0.0015	Kaplan-Meier Survival Analysis
LAML	0.0026	Kaplan-Meier Survival Analysis
UCEC	0.00069	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.00076	Kaplan-Meier Survival Analysis
UVM	0.00034	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000102879 (Gene tree)
Gene ID: 11151
Gene Symbol: CORO1A
Alias: P57|TACO|HCORO1
Full Name: Coronin 1A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 6,250 bases
Position: chr16:30,182,827-30,189,076
Accession: 2252
RBP type: non-canonical RBP
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000570045	CORO1A-216	1622	XM_011545714	ENSP00000455552	461 (aa)	XP_011544016	P31146
ENST00000562129	CORO1A-204	387	-	-	- (aa)	-	-
ENST00000567034	CORO1A-210	2891	-	-	- (aa)	-	-
ENST00000568982	CORO1A-212	756	-	-	- (aa)	-	-
ENST00000569203	CORO1A-213	582	-	ENSP00000454752	148 (aa)	-	H3BNA2
ENST00000564768	CORO1A-207	2236	-	-	- (aa)	-	-
ENST00000568763	CORO1A-211	2809	-	-	- (aa)	-	-
ENST00000565497	CORO1A-208	1348	-	ENSP00000456457	389 (aa)	-	H3BRY3
ENST00000563778	CORO1A-205	937	-	ENSP00000456266	249 (aa)	-	H3BRJ0
ENST00000561849	CORO1A-203	566	-	-	- (aa)	-	-
ENST00000566619	CORO1A-209	577	-	-	- (aa)	-	-
ENST00000569970	CORO1A-215	714	-	ENSP00000457509	165 (aa)	-	H3BU76
ENST00000564446	CORO1A-206	190	-	-	- (aa)	-	-
ENST00000570244	CORO1A-217	844	-	ENSP00000457332	246 (aa)	-	H3BTU6
ENST00000569469	CORO1A-214	560	-	-	- (aa)	-	-
ENST00000561815	CORO1A-202	694	-	ENSP00000456756	218 (aa)	-	H3BSL1
ENST00000219150	CORO1A-201	1803	XM_017022885	ENSP00000219150	461 (aa)	XP_016878374	P31146

Gene Model

Click here to download ENSG00000102879's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04145	Phagosome	KEGG
hsa05152	Tuberculosis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000102879's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001771	immunological synapse formation	24760828.	IMP	Process
GO:0001772	immunological synapse	24760828.	IDA	Component
GO:0001845	phagolysosome assembly	12132654.	IMP	Process
GO:0001891	phagocytic cup	17442961.	IDA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003779	actin binding	23100250.	IPI	Function
GO:0003785	actin monomer binding	23100250.	IMP	Function
GO:0005515	protein binding	11094157.17652161.21988832.25416956.	IPI	Function
GO:0005634	nucleus	17341475.	IDA	Component
GO:0005737	cytoplasm	17341475.	IDA	Component
GO:0005769	early endosome	-	IEA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0005884	actin filament	15800061.	IDA	Component
GO:0005886	plasma membrane	17341475.17442961.	IDA	Component
GO:0005911	cell-cell junction	-	IEA	Component
GO:0006816	calcium ion transport	-	IEA	Process
GO:0006909	phagocytosis	17442961.	IMP	Process
GO:0007015	actin filament organization	-	IEA	Process
GO:0008022	protein C-terminus binding	9365277.	IPI	Function
GO:0008092	cytoskeletal protein binding	-	ISS	Function
GO:0008360	regulation of cell shape	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0030027	lamellipodium	17442961.	IDA	Component
GO:0030036	actin cytoskeleton organization	17442961.	IMP	Process
GO:0030335	positive regulation of cell migration	-	IEA	Process
GO:0030424	axon	-	IEA	Component
GO:0030595	leukocyte chemotaxis	-	IEA	Process
GO:0030670	phagocytic vesicle membrane	-	IEA	Component
GO:0030864	cortical actin cytoskeleton	15800061.	IDA	Component
GO:0030864	cortical actin cytoskeleton	24760828.	IDA	Component
GO:0031339	negative regulation of vesicle fusion	-	IEA	Process
GO:0031589	cell-substrate adhesion	17442961.	IMP	Process
GO:0032036	myosin heavy chain binding	23100250.	IPI	Function
GO:0032796	uropod organization	-	IEA	Process
GO:0032956	regulation of actin cytoskeleton organization	24760828.	IMP	Process
GO:0032991	protein-containing complex	11094157.	IDA	Component
GO:0038180	nerve growth factor signaling pathway	-	IEA	Process
GO:0042102	positive regulation of T cell proliferation	-	IEA	Process
GO:0042803	protein homodimerization activity	15601263.	IDA	Function
GO:0043029	T cell homeostasis	-	IEA	Process
GO:0043320	natural killer cell degranulation	24760828.	IMP	Process
GO:0043524	negative regulation of neuron apoptotic process	-	IEA	Process
GO:0043548	phosphatidylinositol 3-kinase binding	11094157.	IDA	Function
GO:0045087	innate immune response	17341475.	NAS	Process
GO:0045335	phagocytic vesicle	17442961.	IDA	Component
GO:0048873	homeostasis of number of cells within a tissue	-	IEA	Process
GO:0050918	positive chemotaxis	17442961.	IDA	Process
GO:0051015	actin filament binding	7758584.15601263.	IDA	Function
GO:0051015	actin filament binding	22364218.23100250.	IMP	Function
GO:0051126	negative regulation of actin nucleation	17442961.	IDA	Process
GO:0051279	regulation of release of sequestered calcium ion into cytosol	-	IEA	Process
GO:0061502	early endosome to recycling endosome transport	-	IEA	Process
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:0071353	cellular response to interleukin-4	-	IEA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.