EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26522722The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma.Oncogene2016 Jul 7Mizutani Adoi: 10.1038/onc.2015.412
25143390Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms.J Biol Chem2014 Oct 3Ishii Hdoi: 10.1074/jbc.M114.589432
27401076Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression.Adv Exp Med Biol2017Hayakawa Adoi: 10.1007/5584_2016_50.
27911856Splicing factor ratio as an index of epithelial-mesenchymal transition and tumor aggressiveness in breast cancer.Oncotarget2017 Jan 10Fici Pdoi: 10.18632/oncotarget.13682.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1668235699Missense_Mutationrs779673530E88Q0.41
BLCAchr1668235911SilentNAL45L0.52
BLCAchr1668230848Nonsense_MutationnovelY640*0.75
BLCAchr1668230951Frame_Shift_DelnovelS607Lfs*290.29
BLCAchr1668234025Missense_Mutationrs753751967R137Q0.34
BLCAchr1668230430Missense_MutationNAA685P0.29
BLCAchr1668232267Missense_MutationNAE336Q0.41
BLCAchr1668231689Missense_MutationNAL445F0.48
BRCAchr1668232492Missense_MutationNAA288E0.16
BRCAchr1668231633Missense_MutationnovelI464S0.22
BRCAchr1668231615Missense_MutationnovelP470H0.04
BRCAchr1668231211Missense_MutationNAS570G0.44
BRCAchr1668231689Missense_MutationNAL445F0.21
BRCAchr1668231517Missense_Mutationrs372908528R503W0.24
CESCchr1668232409Nonsense_MutationnovelQ316*0.39
CESCchr1668232410Silentrs758240299L315L0.4
CESCchr1668231213Missense_MutationNAR569H0.43
CESCchr1668232488SilentnovelL289L0.68
CESCchr1668231828Missense_MutationNAR435W0.33
COADchr1668232256Missense_MutationNAK339N0.38
COADchr1668232604Missense_Mutationrs748645452R275H0.36
COADchr1668230268SilentNAP714P0.42
COADchr1668230548Frame_Shift_InsnovelV646Sfs*570.2
COADchr1668230852SilentNAA639A0.38
COADchr1668232028Missense_Mutationrs763741902S368L0.49
COADchr16682300873'UTRnovel0.4
COADchr1668230267Missense_Mutationrs569178519R715C0.27
COADchr1668230966Silentrs756594868T601T0.21
ESCAchr1668230861Missense_MutationnovelN636K0.07
ESCAchr1668231361Missense_Mutationrs374057525D520N0.46
GBMchr1668232703Missense_MutationnovelV242E0.21
GBMchr1668232490Missense_MutationnovelL289F0.1
GBMchr1668232446SilentnovelI303I0.19
GBMchr1668232469Missense_MutationnovelR296S0.12
GBMchr1668232028Missense_Mutationrs763741902S368L0.79
GBMchr1668232284Missense_MutationnovelY330S0.09
HNSCchr1668235880Missense_MutationnovelV56L0.19
HNSCchr1668235729Missense_MutationnovelE78K0.15
HNSCchr1668231285Missense_MutationnovelE545V0.35
HNSCchr1668231372Missense_Mutationrs745503556R516Q0.09
KIRCchr1668231611SilentNAG471G0.05
KIRCchr1668230975In_Frame_InsnovelP598_T599insDWD0.03
KIRPchr1668233995Frame_Shift_DelnovelK147Rfs*410.26
KIRPchr1668231863Missense_MutationnovelK423R0.45
LGGchr1668232762Missense_MutationnovelC237R0.3
LIHCchr1668232419Missense_MutationNAD312E0.21
LIHCchr1668231956Missense_MutationnovelL392R0.15
LIHCchr1668231483Frame_Shift_DelnovelM509Rfs*120.29
LIHCchr1668230535Frame_Shift_InsnovelT650Lfs*460.3
LUADchr1668231373SilentnovelR516R0.36
LUADchr1668230445Missense_MutationNAG680R0.26
LUADchr1668231342Missense_MutationNAT526I0.33
LUADchr1668231491SilentnovelL511L0.25
LUADchr1668231254SilentnovelT555T0.08
LUADchr1668232087SilentnovelV348V0.15
LUADchr1668232693SilentNAP245P0.18
LUSCchr1668232388In_Frame_DelnovelH321_G323delinsR0.11
LUSCchr1668232255Missense_MutationnovelI340V0.33
OVchr1668231284Missense_MutationNAE545D0.2
OVchr1668230941Missense_MutationnovelL610V0.13
OVchr1668232474Missense_MutationnovelQ294L0.08
OVchr1668231958SilentNAL391L0.33
PAADchr1668230232Missense_MutationnovelC726W0.17
PAADchr1668230463Missense_Mutationrs747807167A674T0.18
READchr1668230953Missense_MutationNAP606T0.35
READchr1668231846Nonsense_MutationnovelR429*0.38
READchr1668232458Silentrs570243647G299G0.52
READchr1668231241Nonsense_MutationNAR560*0.21
READchr1668231499Missense_MutationnovelM509V0.17
SKCMchr1668231645Missense_Mutationrs759779188P460L0.28
SKCMchr1668234005Missense_MutationnovelA144T0.45
SKCMchr1668234006SilentnovelE143E0.45
SKCMchr1668232407SilentNAQ316Q0.16
SKCMchr1668234085Missense_MutationNAD117G0.71
SKCMchr1668231275SilentnovelV548V0.39
SKCMchr1668234108Splice_SiteNAX110_splice0.2
SKCMchr1668232382Missense_Mutationrs757516890R325C0.28
SKCMchr1668231015Missense_MutationnovelP585L0.36
SKCMchr1668235699Missense_MutationNAE88K0.14
SKCMchr1668232082Missense_MutationNAR350P0.39
SKCMchr1668232059Missense_MutationnovelV358M0.76
SKCMchr1668232069SilentnovelR354R0.19
SKCMchr1668232270Missense_Mutationrs765862714E335K0.22
SKCMchr1668232774Missense_Mutationrs149148189E233K0.29
STADchr1668230549Frame_Shift_DelnovelP645Qfs*430.5
STADchr1668232043Missense_Mutationrs201908706R363Q0.14
STADchr1668235963Missense_MutationNAG28E0.93
STADchr1668232290Splice_SiteNAX329_splice0.27
STADchr1668232775Silentrs752191401Y232Y0.2
STADchr1668230291Missense_MutationNAL707V0.06
STADchr1668231534Frame_Shift_InsnovelE497Gfs*50.3
STADchr1668230539Frame_Shift_DelnovelT649Pfs*390.12
STADchr1668230549Frame_Shift_DelnovelP645Qfs*430.22
STADchr1668231212SilentNAR569R0.21
STADchr1668232586Missense_MutationNAN281S0.21
UCECchr1668234102SilentnovelS111S0.25
UCECchr16682301803'UTRnovel0.43
UCECchr1668231225Missense_MutationnovelG565D0.58
UCECchr1668231309Missense_MutationnovelR537H0.48
UCECchr16682293923'UTRnovel0.36
UCECchr1668232444Missense_Mutationrs763528773R304H0.21
UCECchr1668231232Missense_MutationnovelM563V0.76
UCECchr1668231277Missense_Mutationrs570580551V548M0.18
UCECchr1668231569Silentrs56323755T485T0.23
UCECchr1668231568Missense_MutationnovelA486T0.2
UCECchr1668232802SilentnovelS223S0.27
UCECchr1668233771Nonsense_MutationnovelQ185*0.46
UCECchr16682294223'UTRnovel0.24
UCECchr1668232071Missense_Mutationrs755162828R354W0.22
UCECchr16682294263'UTRnovel0.43
UCECchr1668230252Missense_Mutationrs377274422A720T0.28
UCECchr1668230867SilentnovelY634Y0.31
UCECchr1668231815Missense_MutationNAA439V0.17
UCECchr16682294383'UTRrs7678806300.39
UCECchr1668233426Splice_SitenovelX186_splice0.22
UCECchr1668232413Silentrs376533831A314A0.48
UCECchr1668231966Missense_Mutationrs540156390E389K0.27
UCECchr1668231912Missense_Mutationrs774450234A407T0.45
UCECchr1668230266Missense_Mutationrs371553582R715H0.41
UCECchr1668233840SilentnovelR162R0.44
UCECchr1668232070Missense_MutationnovelR354Q0.3
UCECchr16682301893'UTRnovel0.46
UCECchr1668231530SilentnovelA498A0.26
UCECchr16682295783'UTRnovel1
UCECchr1668231587SilentnovelL479L0.46
UCECchr1668231581SilentNAG481G0.15
UCECchr1668232278Missense_Mutationrs752955291A332V0.32
UCECchr1668233834Nonsense_MutationNAE164*0.48
UCECchr1668233839Missense_Mutationrs779909429R162Q0.49
UCECchr1668233839Missense_Mutationrs779909429R162Q0.09
UCECchr1668232485SilentnovelC290C0.2
UCECchr1668233816Missense_MutationnovelP170S0.3
UCECchr16682294273'UTRnovel0.4
UCECchr1668232444Missense_Mutationrs763528773R304H0.28
UCECchr1668232604Missense_Mutationrs748645452R275H0.44

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.19120.063591
CHOLDEL0.16670.23475
LAMLDEL0.03140.0010312
OVDEL0.76341.5979e-14
TGCTAMP0.120.035574
UCECDEL0.28014.7164e-05

Survival Analysis
CancerP-value Q-value
MESO0.0017

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

PAAD0.029

Kaplan-Meier Survival Analysis

BLCA0.0082

Kaplan-Meier Survival Analysis

LAML0.0039

Kaplan-Meier Survival Analysis

LIHC0.048

Kaplan-Meier Survival Analysis

THCA0.023

Kaplan-Meier Survival Analysis

LUAD0.018

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000103067 (Gene tree)
Gene ID
80004
Gene Symbol
ESRP2
Alias
FLJ21918|RBM35B
Full Name
epithelial splicing regulatory protein 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
9,556 bases
Position
chr16:68,228,547-68,238,102
Accession
26152
RBP type
non-canonical RBP
Summary
ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
31131921Small molecule inhibitors of epithelial-mesenchymal transition for the treatment of cancer and fibrosis.Med Res Rev2019 May 27Feng YLdoi: 10.1002/med.21596
19829082The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events.RNA Biol2009 Nov-DecWarzecha CC-
20348248Genetic and epigenetic mechanisms down-regulate FGF receptor 2 to induce melanoma-associated antigen A in breast cancer.Am J Pathol2010 MayZhu Xdoi: 10.2353/ajpath.2010.091049
27682981Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events.J Cell Physiol2017 JunMatos MLdoi: 10.1002/jcp.25622
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000564465ESRP2-208734--- (aa)--
ENST00000565858ESRP2-2103386-ENSP00000454554727 (aa)-Q9H6T0
ENST00000565213ESRP2-209398--- (aa)--
ENST00000563159ESRP2-206716--- (aa)--
ENST00000566774ESRP2-2112072-ENSP0000046323765 (aa)-J3QKU3
ENST00000562567ESRP2-2031379--- (aa)--
ENST00000569964ESRP2-212572--- (aa)--
ENST00000564382ESRP2-207592-ENSP0000046377082 (aa)-J3QQJ9
ENST00000251366ESRP2-2013228--- (aa)--
ENST00000562724ESRP2-204478-ENSP0000046197043 (aa)-J3KRF2
ENST00000562738ESRP2-205590--- (aa)--
ENST00000473183ESRP2-2023793XM_005256153ENSP00000418748717 (aa)XP_005256210Q9H6T0
Gene Model
Click here to download ENSG00000103067's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000103067rs71848211668236326THighest math class taken30038396[0.013-0.025] unit increase0.0187EFO_0004875
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103067's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000103067ESRP210095.349ENSMUSG00000084128Esrp210093.305Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000380alternative mRNA splicing, via spliceosome-IEAProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003729mRNA binding19285943.IDAFunction
GO:0005634nucleus19285943.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0008543fibroblast growth factor receptor signaling pathway-TASProcess
GO:0043484regulation of RNA splicing19285943.IDAProcess
GO:0050679positive regulation of epithelial cell proliferation-IEAProcess
GO:0060441epithelial tube branching involved in lung morphogenesis-IEAProcess
GO:0060445branching involved in salivary gland morphogenesis-IEAProcess
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