EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26522722	The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma.	Oncogene	2016 Jul 7	Mizutani A	doi: 10.1038/onc.2015.412
25143390	Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms.	J Biol Chem	2014 Oct 3	Ishii H	doi: 10.1074/jbc.M114.589432
27401076	Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression.	Adv Exp Med Biol	2017	Hayakawa A	doi: 10.1007/5584_2016_50.
27911856	Splicing factor ratio as an index of epithelial-mesenchymal transition and tumor aggressiveness in breast cancer.	Oncotarget	2017 Jan 10	Fici P	doi: 10.18632/oncotarget.13682.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr16	68235699	Missense_Mutation	rs779673530	E88Q	0.41
BLCA	chr16	68235911	Silent	NA	L45L	0.52
BLCA	chr16	68230848	Nonsense_Mutation	novel	Y640*	0.75
BLCA	chr16	68230951	Frame_Shift_Del	novel	*S607Lfs29**	0.29
BLCA	chr16	68234025	Missense_Mutation	rs753751967	R137Q	0.34
BLCA	chr16	68230430	Missense_Mutation	NA	A685P	0.29
BLCA	chr16	68232267	Missense_Mutation	NA	E336Q	0.41
BLCA	chr16	68231689	Missense_Mutation	NA	L445F	0.48
BRCA	chr16	68232492	Missense_Mutation	NA	A288E	0.16
BRCA	chr16	68231633	Missense_Mutation	novel	I464S	0.22
BRCA	chr16	68231615	Missense_Mutation	novel	P470H	0.04
BRCA	chr16	68231211	Missense_Mutation	NA	S570G	0.44
BRCA	chr16	68231689	Missense_Mutation	NA	L445F	0.21
BRCA	chr16	68231517	Missense_Mutation	rs372908528	R503W	0.24
CESC	chr16	68232409	Nonsense_Mutation	novel	Q316*	0.39
CESC	chr16	68232410	Silent	rs758240299	L315L	0.4
CESC	chr16	68231213	Missense_Mutation	NA	R569H	0.43
CESC	chr16	68232488	Silent	novel	L289L	0.68
CESC	chr16	68231828	Missense_Mutation	NA	R435W	0.33
COAD	chr16	68232256	Missense_Mutation	NA	K339N	0.38
COAD	chr16	68232604	Missense_Mutation	rs748645452	R275H	0.36
COAD	chr16	68230268	Silent	NA	P714P	0.42
COAD	chr16	68230548	Frame_Shift_Ins	novel	*V646Sfs57**	0.2
COAD	chr16	68230852	Silent	NA	A639A	0.38
COAD	chr16	68232028	Missense_Mutation	rs763741902	S368L	0.49
COAD	chr16	68230087	3'UTR	novel		0.4
COAD	chr16	68230267	Missense_Mutation	rs569178519	R715C	0.27
COAD	chr16	68230966	Silent	rs756594868	T601T	0.21
ESCA	chr16	68230861	Missense_Mutation	novel	N636K	0.07
ESCA	chr16	68231361	Missense_Mutation	rs374057525	D520N	0.46
GBM	chr16	68232703	Missense_Mutation	novel	V242E	0.21
GBM	chr16	68232490	Missense_Mutation	novel	L289F	0.1
GBM	chr16	68232446	Silent	novel	I303I	0.19
GBM	chr16	68232469	Missense_Mutation	novel	R296S	0.12
GBM	chr16	68232028	Missense_Mutation	rs763741902	S368L	0.79
GBM	chr16	68232284	Missense_Mutation	novel	Y330S	0.09
HNSC	chr16	68235880	Missense_Mutation	novel	V56L	0.19
HNSC	chr16	68235729	Missense_Mutation	novel	E78K	0.15
HNSC	chr16	68231285	Missense_Mutation	novel	E545V	0.35
HNSC	chr16	68231372	Missense_Mutation	rs745503556	R516Q	0.09
KIRC	chr16	68231611	Silent	NA	G471G	0.05
KIRC	chr16	68230975	In_Frame_Ins	novel	P598_T599insDWD	0.03
KIRP	chr16	68233995	Frame_Shift_Del	novel	*K147Rfs41**	0.26
KIRP	chr16	68231863	Missense_Mutation	novel	K423R	0.45
LGG	chr16	68232762	Missense_Mutation	novel	C237R	0.3
LIHC	chr16	68232419	Missense_Mutation	NA	D312E	0.21
LIHC	chr16	68231956	Missense_Mutation	novel	L392R	0.15
LIHC	chr16	68231483	Frame_Shift_Del	novel	*M509Rfs12**	0.29
LIHC	chr16	68230535	Frame_Shift_Ins	novel	*T650Lfs46**	0.3
LUAD	chr16	68231373	Silent	novel	R516R	0.36
LUAD	chr16	68230445	Missense_Mutation	NA	G680R	0.26
LUAD	chr16	68231342	Missense_Mutation	NA	T526I	0.33
LUAD	chr16	68231491	Silent	novel	L511L	0.25
LUAD	chr16	68231254	Silent	novel	T555T	0.08
LUAD	chr16	68232087	Silent	novel	V348V	0.15
LUAD	chr16	68232693	Silent	NA	P245P	0.18
LUSC	chr16	68232388	In_Frame_Del	novel	H321_G323delinsR	0.11
LUSC	chr16	68232255	Missense_Mutation	novel	I340V	0.33
OV	chr16	68231284	Missense_Mutation	NA	E545D	0.2
OV	chr16	68230941	Missense_Mutation	novel	L610V	0.13
OV	chr16	68232474	Missense_Mutation	novel	Q294L	0.08
OV	chr16	68231958	Silent	NA	L391L	0.33
PAAD	chr16	68230232	Missense_Mutation	novel	C726W	0.17
PAAD	chr16	68230463	Missense_Mutation	rs747807167	A674T	0.18
READ	chr16	68230953	Missense_Mutation	NA	P606T	0.35
READ	chr16	68231846	Nonsense_Mutation	novel	R429*	0.38
READ	chr16	68232458	Silent	rs570243647	G299G	0.52
READ	chr16	68231241	Nonsense_Mutation	NA	R560*	0.21
READ	chr16	68231499	Missense_Mutation	novel	M509V	0.17
SKCM	chr16	68231645	Missense_Mutation	rs759779188	P460L	0.28
SKCM	chr16	68234005	Missense_Mutation	novel	A144T	0.45
SKCM	chr16	68234006	Silent	novel	E143E	0.45
SKCM	chr16	68232407	Silent	NA	Q316Q	0.16
SKCM	chr16	68234085	Missense_Mutation	NA	D117G	0.71
SKCM	chr16	68231275	Silent	novel	V548V	0.39
SKCM	chr16	68234108	Splice_Site	NA	X110_splice	0.2
SKCM	chr16	68232382	Missense_Mutation	rs757516890	R325C	0.28
SKCM	chr16	68231015	Missense_Mutation	novel	P585L	0.36
SKCM	chr16	68235699	Missense_Mutation	NA	E88K	0.14
SKCM	chr16	68232082	Missense_Mutation	NA	R350P	0.39
SKCM	chr16	68232059	Missense_Mutation	novel	V358M	0.76
SKCM	chr16	68232069	Silent	novel	R354R	0.19
SKCM	chr16	68232270	Missense_Mutation	rs765862714	E335K	0.22
SKCM	chr16	68232774	Missense_Mutation	rs149148189	E233K	0.29
STAD	chr16	68230549	Frame_Shift_Del	novel	*P645Qfs43**	0.5
STAD	chr16	68232043	Missense_Mutation	rs201908706	R363Q	0.14
STAD	chr16	68235963	Missense_Mutation	NA	G28E	0.93
STAD	chr16	68232290	Splice_Site	NA	X329_splice	0.27
STAD	chr16	68232775	Silent	rs752191401	Y232Y	0.2
STAD	chr16	68230291	Missense_Mutation	NA	L707V	0.06
STAD	chr16	68231534	Frame_Shift_Ins	novel	*E497Gfs5**	0.3
STAD	chr16	68230539	Frame_Shift_Del	novel	*T649Pfs39**	0.12
STAD	chr16	68230549	Frame_Shift_Del	novel	*P645Qfs43**	0.22
STAD	chr16	68231212	Silent	NA	R569R	0.21
STAD	chr16	68232586	Missense_Mutation	NA	N281S	0.21
UCEC	chr16	68234102	Silent	novel	S111S	0.25
UCEC	chr16	68230180	3'UTR	novel		0.43
UCEC	chr16	68231225	Missense_Mutation	novel	G565D	0.58
UCEC	chr16	68231309	Missense_Mutation	novel	R537H	0.48
UCEC	chr16	68229392	3'UTR	novel		0.36
UCEC	chr16	68232444	Missense_Mutation	rs763528773	R304H	0.21
UCEC	chr16	68231232	Missense_Mutation	novel	M563V	0.76
UCEC	chr16	68231277	Missense_Mutation	rs570580551	V548M	0.18
UCEC	chr16	68231569	Silent	rs56323755	T485T	0.23
UCEC	chr16	68231568	Missense_Mutation	novel	A486T	0.2
UCEC	chr16	68232802	Silent	novel	S223S	0.27
UCEC	chr16	68233771	Nonsense_Mutation	novel	Q185*	0.46
UCEC	chr16	68229422	3'UTR	novel		0.24
UCEC	chr16	68232071	Missense_Mutation	rs755162828	R354W	0.22
UCEC	chr16	68229426	3'UTR	novel		0.43
UCEC	chr16	68230252	Missense_Mutation	rs377274422	A720T	0.28
UCEC	chr16	68230867	Silent	novel	Y634Y	0.31
UCEC	chr16	68231815	Missense_Mutation	NA	A439V	0.17
UCEC	chr16	68229438	3'UTR	rs767880630		0.39
UCEC	chr16	68233426	Splice_Site	novel	X186_splice	0.22
UCEC	chr16	68232413	Silent	rs376533831	A314A	0.48
UCEC	chr16	68231966	Missense_Mutation	rs540156390	E389K	0.27
UCEC	chr16	68231912	Missense_Mutation	rs774450234	A407T	0.45
UCEC	chr16	68230266	Missense_Mutation	rs371553582	R715H	0.41
UCEC	chr16	68233840	Silent	novel	R162R	0.44
UCEC	chr16	68232070	Missense_Mutation	novel	R354Q	0.3
UCEC	chr16	68230189	3'UTR	novel		0.46
UCEC	chr16	68231530	Silent	novel	A498A	0.26
UCEC	chr16	68229578	3'UTR	novel		1
UCEC	chr16	68231587	Silent	novel	L479L	0.46
UCEC	chr16	68231581	Silent	NA	G481G	0.15
UCEC	chr16	68232278	Missense_Mutation	rs752955291	A332V	0.32
UCEC	chr16	68233834	Nonsense_Mutation	NA	E164*	0.48
UCEC	chr16	68233839	Missense_Mutation	rs779909429	R162Q	0.49
UCEC	chr16	68233839	Missense_Mutation	rs779909429	R162Q	0.09
UCEC	chr16	68232485	Silent	novel	C290C	0.2
UCEC	chr16	68233816	Missense_Mutation	novel	P170S	0.3
UCEC	chr16	68229427	3'UTR	novel		0.4
UCEC	chr16	68232444	Missense_Mutation	rs763528773	R304H	0.28
UCEC	chr16	68232604	Missense_Mutation	rs748645452	R275H	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.1912	0.063591
CHOL	DEL	0.1667	0.23475
LAML	DEL	0.0314	0.0010312
OV	DEL	0.7634	1.5979e-14
TGCT	AMP	0.12	0.035574
UCEC	DEL	0.2801	4.7164e-05

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0017	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.029	Kaplan-Meier Survival Analysis
BLCA	0.0082	Kaplan-Meier Survival Analysis
LAML	0.0039	Kaplan-Meier Survival Analysis
LIHC	0.048	Kaplan-Meier Survival Analysis
THCA	0.023	Kaplan-Meier Survival Analysis
LUAD	0.018	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000103067 (Gene tree)
Gene ID: 80004
Gene Symbol: ESRP2
Alias: FLJ21918|RBM35B
Full Name: epithelial splicing regulatory protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 9,556 bases
Position: chr16:68,228,547-68,238,102
Accession: 26152
RBP type: non-canonical RBP
Summary: ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31131921	Small molecule inhibitors of epithelial-mesenchymal transition for the treatment of cancer and fibrosis.	Med Res Rev	2019 May 27	Feng YL	doi: 10.1002/med.21596
19829082	The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events.	RNA Biol	2009 Nov-Dec	Warzecha CC	-
20348248	Genetic and epigenetic mechanisms down-regulate FGF receptor 2 to induce melanoma-associated antigen A in breast cancer.	Am J Pathol	2010 May	Zhu X	doi: 10.2353/ajpath.2010.091049
27682981	Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events.	J Cell Physiol	2017 Jun	Matos ML	doi: 10.1002/jcp.25622

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000564465	ESRP2-208	734	-	-	- (aa)	-	-
ENST00000565858	ESRP2-210	3386	-	ENSP00000454554	727 (aa)	-	Q9H6T0
ENST00000565213	ESRP2-209	398	-	-	- (aa)	-	-
ENST00000563159	ESRP2-206	716	-	-	- (aa)	-	-
ENST00000566774	ESRP2-211	2072	-	ENSP00000463237	65 (aa)	-	J3QKU3
ENST00000562567	ESRP2-203	1379	-	-	- (aa)	-	-
ENST00000569964	ESRP2-212	572	-	-	- (aa)	-	-
ENST00000564382	ESRP2-207	592	-	ENSP00000463770	82 (aa)	-	J3QQJ9
ENST00000251366	ESRP2-201	3228	-	-	- (aa)	-	-
ENST00000562724	ESRP2-204	478	-	ENSP00000461970	43 (aa)	-	J3KRF2
ENST00000562738	ESRP2-205	590	-	-	- (aa)	-	-
ENST00000473183	ESRP2-202	3793	XM_005256153	ENSP00000418748	717 (aa)	XP_005256210	Q9H6T0

Gene Model

Click here to download ENSG00000103067's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000103067	rs7184821	16	68236326	T	Highest math class taken	30038396	[0.013-0.025] unit increase	0.0187	EFO_0004875

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103067's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000103067	ESRP2	100	95.349	ENSMUSG00000084128	Esrp2	100	93.305	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000380	alternative mRNA splicing, via spliceosome	-	IEA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003729	mRNA binding	19285943.	IDA	Function
GO:0005634	nucleus	19285943.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	Process
GO:0043484	regulation of RNA splicing	19285943.	IDA	Process
GO:0050679	positive regulation of epithelial cell proliferation	-	IEA	Process
GO:0060441	epithelial tube branching involved in lung morphogenesis	-	IEA	Process
GO:0060445	branching involved in salivary gland morphogenesis	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.