EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16537497	Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.	Proc Natl Acad Sci U S A	2006 Mar 14	Liu H	-
16897363	Giant cells: contradiction to two-hit model of tuber formation?	Cell Mol Neurobiol	2007 Mar	Jozwiak J	-
27748010	Renal cell carcinoma harboring somatic TSC2 mutations in a child with methylmalonic acidemia.	Pediatr Blood Cancer	2017 May	Potter SL	doi: 10.1002/pbc.26286
12582162	The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.	J Biol Chem	2003 Apr 18	Li Y	-
17922028	Ras mediates cell survival by regulating tuberin.	Oncogene	2008 Mar 27	Freilinger A	-
27278252	Tuberin regulates reactive oxygen species in renal proximal cells, kidney from rodents, and kidney from patients with tuberous sclerosis complex.	Cancer Sci	2016 Aug	Habib SL	doi: 10.1111/cas.12984
21036916	Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2.	Am J Physiol Lung Cell Mol Physiol	2011 Jan	Ikeda Y	doi: 10.1152/ajplung.00095.2010
16258273	Growth control under stress: mTOR regulation through the REDD1-TSC pathway.	Cell Cycle	2005 Nov	Ellisen LW	-
18926585	Role of TSC-mTOR pathway in diabetic nephropathy.	Diabetes Res Clin Pract	2008 Nov 13	Inoki K	doi: 10.1016/j.diabres.2008.09.028
17470459	p27Kip1 localization depends on the tumor suppressor protein tuberin.	Hum Mol Genet	2007 Jul 1	Rosner M	-
25355409	Imaging features of tuberous sclerosis complex with autosomal-dominant polycystic kidney disease: a contiguous gene syndrome.	Pediatr Radiol	2015 Mar	Back SJ	doi: 10.1007/s00247-014-3147-1
15231735	Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.	Genes Dev	2004 Jul 1	Corradetti MN	-
22090422	Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem-cell differentiation.	Hum Mol Genet	2012 Mar 1	Fuchs C	doi: 10.1093/hmg/ddr535
26975632	Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal cancer.	Cancer Lett	2016 Jun 28	Qin X	doi: 10.1016/j.canlet.2016.03.013
25185584	High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting.	Mol Cancer Res	2015 Jan	Medvetz D	doi: 10.1158/1541-7786.MCR-14-0440
22287548	Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathway.	Cancer Res	2012 Mar 15	Chen W	doi: 10.1158/0008-5472.CAN-11-2684
23878245	Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.	Proc Natl Acad Sci U S A	2013 Aug 6	Tripathi DN	doi: 10.1073/pnas.1307736110
27494029	Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development.	PLoS Genet	2016 Aug 5	Giannikou K	doi: 10.1371/journal.pgen.1006242
20658316	Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes.	Breast Cancer Res Treat	2011 Feb	Mehta MS	doi: 10.1007/s10549-010-1062-1
25114899	Sensitization of cancer cells through reduction of total Akt and downregulation of salinomycin-induced pAkt, pGSk3β, pTSC2, and p4EBP1 by cotreatment with MK-2206.	Biomed Res Int	2014	Choi AR	doi: 10.1155/2014/295760
16213898	Expression and prognostic value of tuberous sclerosis complex 2 gene product tuberin in human pancreatic cancer.	Surgery	2005 Sep	Kataoka K	-
18848473	The TSC-mTOR signaling pathway regulates the innate inflammatory response.	Immunity	2008 Oct 17	Weichhart T	doi: 10.1016/j.immuni.2008.08.012
20145209	ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.	Sci Signal	2010 Feb 9	Kuo HP	doi: 10.1126/scisignal.2000590.
26318033	AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf, and TSC1/TSC2.	Oncotarget	2015 Sep 29	Lin HP	doi: 10.18632/oncotarget.4553.
29167182	TSC2 rare germline variants in non-tuberous sclerosis patients with neuroendocrine neoplasias.	Endocr Relat Cancer	2018 Feb	Asprino PF	doi: 10.1530/ERC-17-0286

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr16	2086868	Missense_Mutation	novel	I1662M	0.05
BLCA	chr16	2079297	Silent	NA	L1051L	0.09
BLCA	chr16	2080214	Silent	novel	F1149F	0.27
BLCA	chr16	2084682	Missense_Mutation	rs766916450	S1487C	0.38
BLCA	chr16	2086223	Missense_Mutation	novel	E1565Q	0.14
BLCA	chr16	2060795	Silent	rs45517149	R367R	0.37
BLCA	chr16	2048702	Silent	novel	R29R	0.33
BLCA	chr16	2079414	Silent	rs754951889	S1090S	0.08
BLCA	chr16	2081629	Silent	rs758114962	P1215P	0.24
BLCA	chr16	2050463	Missense_Mutation	rs767626323	A68T	0.14
BLCA	chr16	2088121	Silent	rs147147042	Q1714Q	0.41
BLCA	chr16	2048648	Silent	novel	L11L	0.34
BLCA	chr16	2065599	Silent	novel	V560V	0.1
BLCA	chr16	2074332	Missense_Mutation	novel	L830V	0.18
BLCA	chr16	2075868	Missense_Mutation	NA	S872F	0.23
BLCA	chr16	2071803	Nonsense_Mutation	NA	E656*	0.26
BLCA	chr16	2086339	Silent	rs147578602	D1603D	0.32
BLCA	chr16	2060793	Missense_Mutation	rs757844109	R367W	0.85
BLCA	chr16	2074382	Silent	novel	F846F	0.47
BLCA	chr16	2080276	Nonsense_Mutation	rs45517296	S1170*	0.12
BLCA	chr16	2077669	Missense_Mutation	rs758447107	S970C	0.6
BRCA	chr16	2054325	Silent	novel	L122L	0.24
BRCA	chr16	2058762	Silent	rs780887572	D288D	0.32
BRCA	chr16	2084656	Silent	rs758374702	D1478D	0.12
BRCA	chr16	2084402	Silent	novel	L1394L	0.32
BRCA	chr16	2062512	Missense_Mutation	NA	N425Y	0.22
BRCA	chr16	2076576	Missense_Mutation	NA	R943K	0.38
BRCA	chr16	2072249	Missense_Mutation	novel	D702E	0.1
BRCA	chr16	2086342	Silent	rs397515103	G1604G	0.27
BRCA	chr16	2085231	Missense_Mutation	NA	S1524L	0.15
BRCA	chr16	2084597	Nonsense_Mutation	rs45517340	R1459*	0.28
BRCA	chr16	2065621	Missense_Mutation	novel	L568V	0.07
BRCA	chr16	2084568	Missense_Mutation	NA	S1449C	0.26
BRCA	chr16	2055459	Missense_Mutation	novel	L180P	0.08
BRCA	chr16	2088235	Silent	novel	S1723S	0.33
CESC	chr16	2071587	Silent	novel	R639R	0.67
CESC	chr16	2072297	Silent	novel	R718R	0.14
CESC	chr16	2079554	Splice_Region	novel		0.19
CESC	chr16	2081602	Silent	NA	T1206T	0.23
CESC	chr16	2088074	Missense_Mutation	rs370864445	V1699M	0.37
CESC	chr16	2058834	Silent	NA	L312L	0.34
CESC	chr16	2079135	Missense_Mutation	NA	E1024K	0.41
CESC	chr16	2086840	Missense_Mutation	rs45517383	S1653F	0.34
CESC	chr16	2081798	Frame_Shift_Ins	novel	*V1272Afs57**	0.09
CESC	chr16	2079554	Splice_Region	novel		0.3
CESC	chr16	2056736	Silent	NA	I247I	0.11
CESC	chr16	2071564	Missense_Mutation	novel	P632S	0.7
CESC	chr16	2056225	Missense_Mutation	rs764925296	A210V	0.33
CESC	chr16	2056644	Missense_Mutation	novel	V217I	0.28
CESC	chr16	2071586	Missense_Mutation	rs753932484	R639Q	0.36
CESC	chr16	2079295	Missense_Mutation	novel	L1051I	0.43
CESC	chr16	2083801	Silent	rs369943684	T1330T	0.39
CESC	chr16	2084619	Missense_Mutation	rs45517341	S1466L	0.36
CESC	chr16	2084390	Nonsense_Mutation	rs397515033	E1390*	0.18
CESC	chr16	2061883	Missense_Mutation	NA	P378T	0.27
CESC	chr16	2076558	Frame_Shift_Ins	novel	*T938Lfs11**	0.06
CESC	chr16	2087871	Missense_Mutation	NA	F1666L	0.26
CESC	chr16	2064342	Missense_Mutation	rs376285784	R505Q	0.43
CESC	chr16	2065599	Silent	NA	V560V	0.32
CESC	chr16	2079075	Missense_Mutation	NA	D1004N	0.31
CESC	chr16	2079354	Silent	rs539927192	T1070T	0.24
CESC	chr16	2076532	Silent	rs45517267	P928P	0.37
COAD	chr16	2053394	Missense_Mutation	NA	R93L	0.07
COAD	chr16	2050436	Missense_Mutation	NA	R59W	0.41
COAD	chr16	2055442	Silent	NA	S174S	0.28
COAD	chr16	2056742	Silent	NA	V249V	0.47
COAD	chr16	2074310	Silent	rs141728350	A822A	0.27
COAD	chr16	2080355	Silent	rs771550363	E1196E	0.34
COAD	chr16	2061920	Missense_Mutation	NA	T390M	0.25
COAD	chr16	2056729	Missense_Mutation	rs397515011	R245H	0.56
COAD	chr16	2088599	Missense_Mutation	rs376017665	E1805K	0.29
COAD	chr16	2079086	Silent	rs201516931	S1007S	0.13
COAD	chr16	2071855	Missense_Mutation	rs745897413	A673V	0.44
COAD	chr16	2080321	Missense_Mutation	NA	A1185V	0.38
COAD	chr16	2084446	Silent	NA	G1408G	0.33
COAD	chr16	2072323	Missense_Mutation	NA	P727H	0.28
COAD	chr16	2080310	Silent	rs139313964	T1181T	0.34
COAD	chr16	2065529	Missense_Mutation	rs372681603	R537H	0.55
COAD	chr16	2086811	Silent	rs45517381	N1643N	0.35
COAD	chr16	2084449	Silent	NA	R1409R	0.11
COAD	chr16	2054303	Missense_Mutation	rs764529584	R115H	0.25
COAD	chr16	2088134	Missense_Mutation	rs201206500	A1719T	0.23
COAD	chr16	2076497	Missense_Mutation	rs781587135	R917W	0.24
COAD	chr16	2072848	Splice_Site	NA	X741_splice	0.15
COAD	chr16	2056711	In_Frame_Del	NA	I240del	0.36
COAD	chr16	2084499	Frame_Shift_Del	NA	*S1427Vfs49**	0.21
COAD	chr16	2048677	Missense_Mutation	novel	L21P	0.2
COAD	chr16	2056716	Missense_Mutation	rs200943828	V241I	0.33
COAD	chr16	2079067	Missense_Mutation	rs368878445	G1001V	0.12
COAD	chr16	2055449	Missense_Mutation	novel	L177F	0.04
ESCA	chr16	2081768	Missense_Mutation	novel	K1262E	0.18
ESCA	chr16	2061976	Nonsense_Mutation	novel	E409*	0.29
ESCA	chr16	2080298	Silent	novel	V1177V	0.25
ESCA	chr16	2084251	Silent	novel	E1343E	0.33
ESCA	chr16	2053478	Intron	novel		0.47
ESCA	chr16	2076498	Missense_Mutation	rs397515046	R917Q	0.67
ESCA	chr16	2060682	Missense_Mutation	novel	P330A	0.26
ESCA	chr16	2076083	Silent	novel	I885I	0.12
ESCA	chr16	2053375	Missense_Mutation	novel	D87Y	0.38
GBM	chr16	2072905	Missense_Mutation	novel	R759S	0.5
GBM	chr16	2085281	Missense_Mutation	rs796872464	D1541N	0.07
GBM	chr16	2074250	Missense_Mutation	novel	S802R	0.12
GBM	chr16	2084715	Missense_Mutation	rs137854879	S1498N	0.13
GBM	chr16	2088136	Silent	novel	A1719A	0.21
GBM	chr16	2074319	Silent	novel	V825V	0.19
GBM	chr16	2070541	Missense_Mutation	novel	S601I	0.71
GBM	chr16	2088317	Missense_Mutation	rs781630603	R1751C	0.76
HNSC	chr16	2077693	Missense_Mutation	NA	R978H	0.19
HNSC	chr16	2085262	Silent	rs368534883	L1534L	0.15
HNSC	chr16	2070558	Missense_Mutation	rs45517203	A607T	0.33
HNSC	chr16	2061961	Nonsense_Mutation	rs45457701	Q404*	0.22
HNSC	chr16	2082474	Missense_Mutation	novel	G1285R	0.04
HNSC	chr16	2071791	Missense_Mutation	novel	E652Q	0.17
HNSC	chr16	2048709	Missense_Mutation	novel	E32Q	0.08
HNSC	chr16	2077658	Silent	novel	F966F	0.26
HNSC	chr16	2048602	5'UTR	novel		0.1
KICH	chr16	2063033	Missense_Mutation	novel	I475F	0.43
KICH	chr16	2079289	Missense_Mutation	rs796053492	E1049K	0.42
KIRC	chr16	2061907	Missense_Mutation	NA	D386N	0.33
KIRC	chr16	2081630	Missense_Mutation	NA	L1216I	0.13
KIRC	chr16	2075856	Missense_Mutation	novel	V868E	0.25
KIRC	chr16	2080378	Splice_Site	novel	X1204_splice	0.3
KIRC	chr16	2065578	Silent	NA	Y553Y	0.27
KIRC	chr16	2084518	Silent	NA	A1432A	0.4
KIRC	chr16	2082492	Missense_Mutation	rs201135184	V1291I	0.28
KIRP	chr16	2076138	Missense_Mutation	NA	F904L	0.12
KIRP	chr16	2061921	Silent	novel	T390T	0.05
KIRP	chr16	2062990	Silent	novel	A460A	0.23
KIRP	chr16	2088134	Missense_Mutation	rs201206500	A1719T	0.35
KIRP	chr16	2085238	Frame_Shift_Ins	novel	E1528*	0.1
KIRP	chr16	2072848	Splice_Site	NA	X741_splice	0.47
KIRP	chr16	2080344	Missense_Mutation	NA	G1193S	0.28
KIRP	chr16	2048729	Silent	novel	F38F	0.23
KIRP	chr16	2084693	Missense_Mutation	novel	K1491E	0.53
LGG	chr16	2072980	Missense_Mutation	NA	K784N	0.22
LGG	chr16	2088114	Missense_Mutation	NA	A1712G	0.4
LGG	chr16	2055474	Missense_Mutation	novel	K185R	0.32
LGG	chr16	2075815	Silent	rs779606786	P854P	0.44
LIHC	chr16	2080278	Frame_Shift_Del	novel	*A1171Lfs20**	0.14
LIHC	chr16	2054354	Frame_Shift_Del	novel	*N133Tfs49**	0.07
LIHC	chr16	2086370	Frame_Shift_Del	novel	*I1614Hfs38**	0.11
LIHC	chr16	2086305	In_Frame_Del	novel	Y1593_L1594del	0.21
LIHC	chr16	2072983	Frame_Shift_Del	novel		0.42
LIHC	chr16	2054374	Missense_Mutation	novel	R139W	0.32
LIHC	chr16	2088084	Frame_Shift_Del	novel	*I1702Sfs123**	0.34
LIHC	chr16	2086834	Frame_Shift_Del	novel	*N1651Kfs48**	0.44
LIHC	chr16	2084405	Nonsense_Mutation	NA	Q1395*	0.21
LIHC	chr16	2062587	Nonsense_Mutation	rs45491095	E450*	0.76
LIHC	chr16	2048718	Nonsense_Mutation	rs137854105	Q35*	0.22
LIHC	chr16	2074224	Nonsense_Mutation	rs45517233	Q794*	0.45
LIHC	chr16	2058809	Nonsense_Mutation	rs45517140	W304*	0.5
LUAD	chr16	2080193	Silent	novel	L1142L	0.05
LUAD	chr16	2072924	Missense_Mutation	novel	V766L	0.1
LUAD	chr16	2079152	Missense_Mutation	novel	M1029I	0.19
LUAD	chr16	2065573	Missense_Mutation	NA	A552T	0.06
LUAD	chr16	2064373	Frame_Shift_Del	novel	*A516Qfs19**	0.53
LUAD	chr16	2054433	Silent	NA	E158E	0.12
LUAD	chr16	2065636	Splice_Site	NA	X572_splice	0.27
LUAD	chr16	2060756	Missense_Mutation	NA	Q354H	0.2
LUAD	chr16	2055463	Silent	novel	V181V	0.15
LUAD	chr16	2055464	Missense_Mutation	novel	N182Y	0.15
LUAD	chr16	2079275	Splice_Site	rs45443096	X1044_splice	0.24
LUAD	chr16	2070499	Missense_Mutation	novel	Y587C	0.15
LUAD	chr16	2079039	Nonsense_Mutation	rs45438592	Q992*	0.17
LUAD	chr16	2061937	Missense_Mutation	NA	D396Y	0.17
LUAD	chr16	2056211	Silent	novel	L205L	0.61
LUAD	chr16	2071807	Missense_Mutation	novel	K657R	1
LUSC	chr16	2065582	Missense_Mutation	novel	A555S	0.51
LUSC	chr16	2074227	Missense_Mutation	novel	G795S	0.3
LUSC	chr16	2079555	Splice_Site	NA	X1095_splice	0.54
LUSC	chr16	2056206	Silent	novel	L204L	0.19
LUSC	chr16	2084977	Frame_Shift_Del	novel	*P1508Lfs15**	0.27
LUSC	chr16	2081786	Missense_Mutation	novel	R1268C	0.16
LUSC	chr16	2079609	Nonsense_Mutation	NA	E1113*	0.28
LUSC	chr16	2050412	Nonsense_Mutation	novel	E51*	0.94
LUSC	chr16	2088267	Frame_Shift_Ins	novel	*I1735Yfs40**	0.09
LUSC	chr16	2088579	Missense_Mutation	novel	S1798C	0.48
LUSC	chr16	2076130	Missense_Mutation	NA	R901H	0.25
LUSC	chr16	2056195	Splice_Site	NA	X200_splice	0.4
LUSC	chr16	2083708	Silent	novel	V1299V	0.5
LUSC	chr16	2088230	Missense_Mutation	rs397515270	A1722P	0.08
LUSC	chr16	2086756	Missense_Mutation	novel	M1625T	0.35
LUSC	chr16	2061903	Silent	novel	V384V	0.29
LUSC	chr16	2086246	Silent	rs369346726	T1572T	0.13
LUSC	chr16	2085246	Missense_Mutation	novel	R1529L	0.15
LUSC	chr16	2079165	Frame_Shift_Del	novel	*V1034Sfs18**	0.06
LUSC	chr16	2076550	Missense_Mutation	novel	R934S	0.17
LUSC	chr16	2056690	Missense_Mutation	rs760100924	P232L	0.31
MESO	chr16	2084300	Missense_Mutation	rs397514997	E1360K	0.09
OV	chr16	2086352	Missense_Mutation	NA	Y1608D	0.79
OV	chr16	2055455	Frame_Shift_Ins	novel	*V179Gfs16**	0.05
OV	chr16	2081696	Missense_Mutation	novel	A1238P	0.84
OV	chr16	2080219	Missense_Mutation	novel	G1151A	0.69
OV	chr16	2057108	Missense_Mutation	NA	M260V	0.66
OV	chr16	2061945	Missense_Mutation	novel	N398K	0.06
OV	chr16	2060745	Missense_Mutation	novel	K351Q	0.46
OV	chr16	2083670	Intron	novel		0.58
OV	chr16	2056752	Missense_Mutation	novel	C253G	0.1
OV	chr16	2074238	Frame_Shift_Del	novel	*R799Afs25**	0.29
OV	chr16	2079152	Missense_Mutation	NA	M1029I	0.44
PAAD	chr16	2086296	Missense_Mutation	rs373635516	P1589L	0.37
PAAD	chr16	2062581	Silent	novel	L448L	0.16
PAAD	chr16	2070559	Missense_Mutation	rs397515296	A607V	0.19
PAAD	chr16	2074211	Silent	novel	V789V	0.18
PAAD	chr16	2079278	Missense_Mutation	novel	S1045F	0.19
PAAD	chr16	2080328	Silent	novel	V1187V	0.18
PAAD	chr16	2084251	Missense_Mutation	novel	E1343D	0.3
PAAD	chr16	2086298	Missense_Mutation	novel	D1590N	0.22
PAAD	chr16	2057129	Missense_Mutation	novel	H267N	0.4
PCPG	chr16	2081702	Missense_Mutation	rs137854353	R1240C	0.07
PRAD	chr16	2071839	Missense_Mutation	novel	G668W	0.4
PRAD	chr16	2086229	Missense_Mutation	novel	G1567R	0.51
PRAD	chr16	2076129	Missense_Mutation	rs796053512	R901C	0.37
PRAD	chr16	2060815	Splice_Site	novel	X373_splice	0.32
READ	chr16	2060790	Missense_Mutation	rs45517148	E366K	0.09
READ	chr16	2064382	Silent	NA	G518G	0.39
READ	chr16	2071552	Missense_Mutation	rs45437797	R628C	0.12
READ	chr16	2083557	Intron	novel		0.4
SARC	chr16	2081749	Silent	novel	V1255V	0.07
SARC	chr16	2060733	Frame_Shift_Del	novel	*K347Rfs16**	0.45
SARC	chr16	2057141	Frame_Shift_Del	novel	*S271Rfs66**	0.43
SARC	chr16	2076102	Missense_Mutation	rs376801256	V892I	0.23
SARC	chr16	2065568	Frame_Shift_Del	novel	A551*	0.55
SKCM	chr16	2088455	Missense_Mutation	NA	E1757K	0.26
SKCM	chr16	2079086	Silent	rs201516931	S1007S	0.48
SKCM	chr16	2072879	Nonsense_Mutation	rs45517222	R751*	0.35
SKCM	chr16	2060708	Silent	NA	I338I	0.3
SKCM	chr16	2084514	Missense_Mutation	rs375785710	S1431L	0.18
SKCM	chr16	2061907	Missense_Mutation	NA	D386N	0.64
SKCM	chr16	2071512	Splice_Region	rs201575136	A614A	0.6
SKCM	chr16	2064418	Silent	NA	I530I	0.34
SKCM	chr16	2079297	Silent	NA	L1051L	0.36
SKCM	chr16	2088109	Silent	rs760978505	F1710F	0.15
SKCM	chr16	2047868	5'UTR	NA		0.5
SKCM	chr16	2072312	Silent	novel	I723I	0.2
SKCM	chr16	2074230	Missense_Mutation	NA	L796F	0.18
SKCM	chr16	2081775	Missense_Mutation	rs762822990	P1264L	0.58
SKCM	chr16	2080179	Nonsense_Mutation	rs45451497	R1138*	0.27
SKCM	chr16	2087897	Missense_Mutation	rs45483392	P1675L	0.35
SKCM	chr16	2081642	Missense_Mutation	NA	S1220T	0.34
SKCM	chr16	2075885	Missense_Mutation	rs397515077	P878S	0.49
SKCM	chr16	2075886	Missense_Mutation	novel	P878L	0.49
SKCM	chr16	2072857	Silent	novel	G743G	0.23
SKCM	chr16	2084434	Silent	novel	K1404K	0.29
SKCM	chr16	2081600	Missense_Mutation	NA	T1206A	0.33
SKCM	chr16	2056231	Missense_Mutation	novel	S212F	0.24
SKCM	chr16	2079565	Missense_Mutation	rs773545852	P1098L	0.79
SKCM	chr16	2056222	Missense_Mutation	NA	T209I	0.34
SKCM	chr16	2054436	Silent	novel	E159E	0.37
SKCM	chr16	2072931	Missense_Mutation	NA	P768L	0.39
SKCM	chr16	2083789	Missense_Mutation	NA	M1326I	0.24
SKCM	chr16	2084314	Silent	NA	S1364S	0.27
SKCM	chr16	2065517	Splice_Site	NA	X534_splice	0.05
SKCM	chr16	2079312	Silent	NA	R1056R	0.64
SKCM	chr16	2062523	Silent	NA	S428S	0.33
SKCM	chr16	2080176	Missense_Mutation	NA	L1137F	0.29
SKCM	chr16	2048704	Missense_Mutation	NA	S30Y	0.23
SKCM	chr16	2075864	Missense_Mutation	NA	I871L	0.33
SKCM	chr16	2055448	Silent	NA	F176F	0.27
SKCM	chr16	2055449	Missense_Mutation	novel	L177F	0.27
SKCM	chr16	2060708	Silent	NA	I338I	0.3
SKCM	chr16	2077661	Silent	NA	K967K	0.31
STAD	chr16	2074337	Silent	rs773645613	T831T	0.1
STAD	chr16	2056664	Silent	rs35501344	D223D	0.24
STAD	chr16	2056668	Missense_Mutation	rs142919353	V225M	0.22
STAD	chr16	2055424	Missense_Mutation	NA	M168I	0.39
STAD	chr16	2084592	Missense_Mutation	NA	R1457Q	0.24
STAD	chr16	2071605	Silent	novel	V645V	0.3
STAD	chr16	2072295	Missense_Mutation	rs182538665	R718C	0.19
STAD	chr16	2070491	Silent	rs141285742	T584T	0.18
STAD	chr16	2074275	Missense_Mutation	NA	C811R	0.2
STAD	chr16	2056755	Missense_Mutation	rs45517126	E254K	0.28
STAD	chr16	2081668	Silent	NA	L1228L	0.38
STAD	chr16	2086306	Silent	NA	V1592V	0.4
STAD	chr16	2080220	Silent	novel	G1151G	0.35
STAD	chr16	2056226	Silent	rs567756494	A210A	0.28
STAD	chr16	2070493	Missense_Mutation	rs397515063	R585H	0.25
STAD	chr16	2074373	Silent	NA	L843L	0.25
STAD	chr16	2056735	Missense_Mutation	novel	I247T	0.32
STAD	chr16	2074282	Missense_Mutation	novel	V813A	0.14
STAD	chr16	2080301	Silent	rs201305783	Q1178Q	0.26
STAD	chr16	2088461	Missense_Mutation	rs758450326	A1759T	0.37
STAD	chr16	2055505	Silent	rs397515309	I195I	0.32
STAD	chr16	2060687	Silent	rs45517153	N331N	0.24
STAD	chr16	2088300	Missense_Mutation	rs766093661	R1745H	0.16
STAD	chr16	2048715	Frame_Shift_Del	novel	*K34Nfs12**	0.28
STAD	chr16	2088051	Missense_Mutation	rs397515110	M1691T	0.28
STAD	chr16	2060800	Missense_Mutation	NA	L369R	0.24
STAD	chr16	2064385	Silent	novel	C519C	0.36
STAD	chr16	2077693	Missense_Mutation	NA	R978H	0.31
STAD	chr16	2081647	Silent	rs137854268	S1221S	0.31
STAD	chr16	2076083	Silent	NA	I885I	0.38
THCA	chr16	2048651	Silent	novel	K12K	0.06
THYM	chr16	2076080	Nonsense_Mutation	novel	Y884*	0.08
UCEC	chr16	2084620	Silent	rs376086638	S1466S	0.18
UCEC	chr16	2058830	Missense_Mutation	NA	S311F	0.16
UCEC	chr16	2056728	Missense_Mutation	rs375574283	R245C	0.15
UCEC	chr16	2058784	Missense_Mutation	rs747237113	V296M	0.15
UCEC	chr16	2086208	Missense_Mutation	rs777539610	A1560T	0.15
UCEC	chr16	2086820	Silent	novel	V1646V	0.09
UCEC	chr16	2083777	Silent	novel	A1322A	0.29
UCEC	chr16	2057168	Missense_Mutation	novel	M280L	0.62
UCEC	chr16	2064304	Silent	novel	Q492Q	0.61
UCEC	chr16	2082491	Silent	rs754466663	S1290S	0.51
UCEC	chr16	2048663	Missense_Mutation	novel	K16N	0.34
UCEC	chr16	2084514	Missense_Mutation	rs375785710	S1431L	0.24
UCEC	chr16	2086163	Splice_Site	novel	X1555_splice	0.27
UCEC	chr16	2065529	Missense_Mutation	rs372681603	R537H	0.31
UCEC	chr16	2061887	Missense_Mutation	NA	E379G	0.27
UCEC	chr16	2054303	Missense_Mutation	rs764529584	R115H	0.23
UCEC	chr16	2065635	Missense_Mutation	NA	Q572H	0.11
UCEC	chr16	2084954	Silent	rs372974007	F1499F	0.23
UCEC	chr16	2083795	Silent	NA	R1328R	0.3
UCEC	chr16	2048654	Missense_Mutation	rs766814650	E13D	0.15
UCEC	chr16	2088324	Missense_Mutation	rs749487441	R1753Q	0.26
UCEC	chr16	2058764	Missense_Mutation	rs755631210	A289V	0.47
UCEC	chr16	2060708	Silent	NA	I338I	0.08
UCEC	chr16	2081778	Missense_Mutation	novel	P1265H	0.11
UCEC	chr16	2060764	Missense_Mutation	rs150195368	A357V	0.16
UCEC	chr16	2079308	Missense_Mutation	NA	G1055D	0.16
UCEC	chr16	2088117	Missense_Mutation	rs45517395	R1713H	0.2
UCEC	chr16	2053372	Missense_Mutation	NA	A86T	0.26
UCEC	chr16	2058784	Missense_Mutation	rs747237113	V296M	0.26
UCEC	chr16	2076571	Silent	rs750806272	N941N	0.59
UCEC	chr16	2079165	Missense_Mutation	rs146745242	V1034I	0.41
UCEC	chr16	2079652	Missense_Mutation	rs746197874	R1127Q	0.38
UCEC	chr16	2081729	Missense_Mutation	novel	L1249M	0.3
UCEC	chr16	2085298	Silent	rs45517354	A1546A	0.35
UCEC	chr16	2072350	Missense_Mutation	rs764259520	A736V	0.23
UCEC	chr16	2070558	Missense_Mutation	rs45517203	A607T	0.52
UCEC	chr16	2056762	Missense_Mutation	NA	C256Y	0.46
UCEC	chr16	2048663	Missense_Mutation	novel	K16N	0.07
UCEC	chr16	2079278	Missense_Mutation	novel	S1045Y	0.31
UCEC	chr16	2084535	Missense_Mutation	rs45448791	R1438Q	0.46
UCEC	chr16	2071534	Missense_Mutation	rs397514914	R622W	0.32
UCEC	chr16	2084379	Missense_Mutation	novel	S1386I	0.09
UCEC	chr16	2088109	Silent	rs760978505	F1710F	0.38
UCEC	chr16	2056217	Frame_Shift_Del	novel	*T209Vfs24**	0.09
UCEC	chr16	2071618	Splice_Site	rs397515247	X649_splice	0.41
UCEC	chr16	2075877	Missense_Mutation	novel	Y875C	0.35
UCEC	chr16	2083760	Silent	novel	L1317L	0.33
UCEC	chr16	2085253	Silent	novel	V1531V	0.17
UCEC	chr16	2084244	Missense_Mutation	novel	S1341N	0.47
UCEC	chr16	2084514	Missense_Mutation	rs375785710	S1431L	0.31
UCEC	chr16	2083626	Intron	novel		0.14
UCEC	chr16	2050430	Missense_Mutation	novel	R57C	0.43
UCEC	chr16	2079415	Missense_Mutation	rs796053493	G1091S	0.26
UCEC	chr16	2084960	Silent	rs778332133	F1501F	0.39
UCEC	chr16	2048651	Missense_Mutation	novel	K12N	0.38
UCEC	chr16	2048744	Missense_Mutation	novel	E43D	0.31
UCEC	chr16	2086208	Missense_Mutation	rs777539610	A1560T	0.33
UCEC	chr16	2088461	Missense_Mutation	rs758450326	A1759T	0.4
UCEC	chr16	2084477	Nonsense_Mutation	rs45437193	Q1419*	0.26
UCEC	chr16	2055484	Missense_Mutation	novel	S188R	0.21
UCEC	chr16	2086733	Splice_Region	rs556045045	A1617A	0.2
UCEC	chr16	2076497	Missense_Mutation	rs781587135	R917W	0.53
UCEC	chr16	2079102	Missense_Mutation	rs45517279	D1013N	0.88
UCEC	chr16	2070493	Missense_Mutation	rs397515063	R585H	0.56
UCEC	chr16	2056649	Silent	NA	S218S	0.47
UCEC	chr16	2056195	Splice_Site	rs45517117	X200_splice	0.41
UCEC	chr16	2065538	Frame_Shift_Del	novel	*P541Hfs20**	0.34
UCEC	chr16	2055407	Frame_Shift_Del	NA	*F163Cfs25**	0.24
UCEC	chr16	2053481	Intron	novel		0.23
UCEC	chr16	2058765	Silent	rs375163125	A289A	0.32
UCEC	chr16	2080214	Silent	novel	F1149F	0.3
UCEC	chr16	2088643	3'UTR	novel		0.13
UCEC	chr16	2084573	Missense_Mutation	rs369553241	R1451C	0.47
UCEC	chr16	2072279	Silent	novel	R712R	0.35
UCEC	chr16	2076083	Silent	novel	I885I	0.05
UCEC	chr16	2050445	Missense_Mutation	novel	G62W	0.38
UCEC	chr16	2062986	Missense_Mutation	novel	G459D	0.64
UCEC	chr16	2079108	Missense_Mutation	novel	L1015M	0.28
UCEC	chr16	2065529	Missense_Mutation	rs372681603	R537H	0.43
UCEC	chr16	2079044	Silent	rs45517277	T993T	0.33
UCEC	chr16	2056235	Silent	novel	V213V	0.34
UCEC	chr16	2079414	Silent	rs754951889	S1090S	0.4
UCEC	chr16	2063012	Missense_Mutation	novel	V468M	0.3
UCEC	chr16	2070453	Splice_Region	novel		0.39
UCEC	chr16	2077604	Silent	NA	R948R	0.35
UCEC	chr16	2088266	Missense_Mutation	rs751990617	D1734N	0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.5333	0.22898
CHOL	DEL	0.1111	0.23475

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.029	Kaplan-Meier Survival Analysis
MESO	0.037	Kaplan-Meier Survival Analysis
HNSC	0.00038	Kaplan-Meier Survival Analysis
SKCM	0.0096	Kaplan-Meier Survival Analysis
PAAD	0.00093	Kaplan-Meier Survival Analysis
READ	0.021	Kaplan-Meier Survival Analysis
LGG	0.04	Kaplan-Meier Survival Analysis
LUAD	0.024	Kaplan-Meier Survival Analysis
UVM	0.0012	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000103197 (Gene tree)
Gene ID: 7249
Gene Symbol: TSC2
Alias: tuberin|LAM|PPP1R160|TSC4
Full Name: TSC complex subunit 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 42,023 bases
Position: chr16:2,047,465-2,089,487
Accession: 12363
RBP type: non-canonical RBP
Summary: Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24189100	MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1.	Autophagy	2013 Dec	Wang Y	doi: 10.4161/auto.26447
20304964	The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.	Am J Pathol	2010 May	Block K	doi: 10.2353/ajpath.2010.090606

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000646674	TSC2-264	2710	-	-	- (aa)	-	-
ENST00000646464	TSC2-261	461	-	ENSP00000496610	65 (aa)	-	A0A2R8YHA2
ENST00000644665	TSC2-252	3604	-	-	- (aa)	-	-
ENST00000645186	TSC2-256	541	-	ENSP00000495110	180 (aa)	-	A0A2R8Y670
ENST00000568692	TSC2-224	1695	-	-	- (aa)	-	-
ENST00000646388	TSC2-260	5614	-	ENSP00000495921	1805 (aa)	-	A0A2R8YGD6
ENST00000647234	TSC2-268	4228	-	-	- (aa)	-	-
ENST00000643149	TSC2-237	4117	-	-	- (aa)	-	-
ENST00000568366	TSC2-221	562	-	-	- (aa)	-	-
ENST00000439117	TSC2-206	5073	-	ENSP00000406980	108 (aa)	-	Q5HYF7
ENST00000642797	TSC2-232	5388	XM_005255531	ENSP00000493846	1741 (aa)	XP_005255588	X5D2U8
ENST00000645024	TSC2-255	3475	-	-	- (aa)	-	-
ENST00000467949	TSC2-211	606	-	-	- (aa)	-	-
ENST00000568238	TSC2-220	422	-	-	- (aa)	-	-
ENST00000642791	TSC2-231	1855	-	-	- (aa)	-	-
ENST00000643120	TSC2-236	792	-	-	- (aa)	-	-
ENST00000647042	TSC2-266	2729	-	-	- (aa)	-	-
ENST00000642561	TSC2-229	5396	-	ENSP00000495099	1760 (aa)	-	A0A2R8YDZ2
ENST00000563346	TSC2-219	703	-	-	- (aa)	-	-
ENST00000643533	TSC2-241	516	-	-	- (aa)	-	-
ENST00000497886	TSC2-216	3248	-	-	- (aa)	-	-
ENST00000643426	TSC2-240	3123	-	-	- (aa)	-	-
ENST00000646634	TSC2-263	4321	-	-	- (aa)	-	-
ENST00000646823	TSC2-265	1536	-	-	- (aa)	-	-
ENST00000432909	TSC2-205	408	-	ENSP00000387937	136 (aa)	-	C9JX95
ENST00000644278	TSC2-247	649	-	-	- (aa)	-	-
ENST00000569110	TSC2-225	1727	-	ENSP00000455817	316 (aa)	-	H3BQK4
ENST00000643088	TSC2-235	5970	-	ENSP00000494747	1738 (aa)	-	A0A2R8Y5F1
ENST00000642812	TSC2-233	2320	-	-	- (aa)	-	-
ENST00000568566	TSC2-223	542	-	ENSP00000455997	30 (aa)	-	H3BQY7
ENST00000642936	TSC2-234	5507	XM_011522640	ENSP00000494514	1763 (aa)	XP_011520942	P49815
ENST00000644335	TSC2-249	5433	-	ENSP00000496317	1739 (aa)	-	A0A2R8YGU4
ENST00000488675	TSC2-214	567	-	-	- (aa)	-	-
ENST00000439673	TSC2-207	5287	XM_017023617	ENSP00000399232	1704 (aa)	XP_016879106	P49815
ENST00000644399	TSC2-250	5445	-	ENSP00000493990	1781 (aa)	-	A0A2R8YDR3
ENST00000646557	TSC2-262	478	-	-	- (aa)	-	-
ENST00000647242	TSC2-269	2749	-	-	- (aa)	-	-
ENST00000569930	TSC2-226	3388	-	-	- (aa)	-	-
ENST00000644417	TSC2-251	436	-	ENSP00000493912	86 (aa)	-	A0A2R8YCR8
ENST00000645192	TSC2-257	209	-	-	- (aa)	-	-
ENST00000562474	TSC2-218	589	-	-	- (aa)	-	-
ENST00000644847	TSC2-254	1735	-	-	- (aa)	-	-
ENST00000645591	TSC2-259	3488	-	-	- (aa)	-	-
ENST00000642365	TSC2-228	4122	XM_017023618	ENSP00000495459	1359 (aa)	XP_016879107	A0A2R8Y6C9
ENST00000461648	TSC2-208	2793	-	-	- (aa)	-	-
ENST00000643298	TSC2-239	2963	-	ENSP00000494393	237 (aa)	-	A0A2R8Y5B2
ENST00000644722	TSC2-253	992	-	-	- (aa)	-	-
ENST00000643177	TSC2-238	1181	-	-	- (aa)	-	-
ENST00000647180	TSC2-267	2617	-	-	- (aa)	-	-
ENST00000463601	TSC2-209	2529	-	-	- (aa)	-	-
ENST00000463808	TSC2-210	842	-	-	- (aa)	-	-
ENST00000471143	TSC2-212	579	-	ENSP00000458541	32 (aa)	-	I3L134
ENST00000642206	TSC2-227	335	-	ENSP00000495146	88 (aa)	-	A0A2R8Y692
ENST00000219476	TSC2-201	6164	XM_011522636	ENSP00000219476	1807 (aa)	XP_011520938	P49815
ENST00000401874	TSC2-204	5437	-	ENSP00000384468	1740 (aa)	-	P49815
ENST00000490108	TSC2-215	482	-	-	- (aa)	-	-
ENST00000483020	TSC2-213	563	-	ENSP00000460310	35 (aa)	-	I3L3B1
ENST00000643745	TSC2-242	2588	-	ENSP00000495948	384 (aa)	-	A0A2R8YGE6
ENST00000642728	TSC2-230	1171	-	-	- (aa)	-	-
ENST00000382538	TSC2-203	5264	-	ENSP00000371978	1692 (aa)	-	P49815
ENST00000644329	TSC2-248	5453	XM_024450413	ENSP00000496611	1769 (aa)	XP_024306181	A0A2R8Y7X5
ENST00000350773	TSC2-202	5538	-	ENSP00000344383	1784 (aa)	-	P49815
ENST00000644043	TSC2-244	5457	XM_005255529	ENSP00000496262	1764 (aa)	XP_005255586	P49815
ENST00000644222	TSC2-246	2433	-	-	- (aa)	-	-
ENST00000644135	TSC2-245	2277	-	ENSP00000495644	572 (aa)	-	A0A2R8YEJ8
ENST00000568454	TSC2-222	5429	-	ENSP00000454487	1751 (aa)	-	H3BMQ0
ENST00000643946	TSC2-243	6344	-	ENSP00000495927	1782 (aa)	-	A0A2R8Y7C8
ENST00000561695	TSC2-217	555	-	-	- (aa)	-	-
ENST00000645552	TSC2-258	1706	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000103197's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04072	Phospholipase D signaling pathway	KEGG
hsa04115	p53 signaling pathway	KEGG
hsa04140	Autophagy - animal	KEGG
hsa04150	mTOR signaling pathway	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04152	AMPK signaling pathway	KEGG
hsa04211	Longevity regulating pathway	KEGG
hsa04218	Cellular senescence	KEGG
hsa04714	Thermogenesis	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05165	Human papillomavirus infection	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG
hsa05231	Choline metabolism in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000103197	Longevity	1E-6	20834067
ENSG00000103197	Insulin-Like Growth Factor Binding Protein 3	5E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000103197	rs45502703	16	2057112	G	Obesity-related traits	23251661	[NR] ng/mL increase	0.03	EFO_0004626
ENSG00000103197	rs8050755	16	2069186	T	Major depressive disorder	29317602	[0.071-0.149] unit increase	0.11	EFO_0003761

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103197's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001843	neural tube closure	-	ISS	Process
GO:0005096	GTPase activator activity	21873635.	IBA	Function
GO:0005096	GTPase activator activity	9045618.	IDA	Function
GO:0005515	protein binding	9580671.9809973.10585443.12176984.12364343.12582162.15161933.16636147.17693255.18381890.18692468.19389623.20169078.20169165.20412061.20618440.21134130.24255178.25263562.27451907.	IPI	Function
GO:0005634	nucleus	17114346.	IDA	Component
GO:0005634	nucleus	16636147.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	9580671.16636147.	IDA	Component
GO:0005737	cytoplasm	17114346.	IDA	Component
GO:0005764	lysosome	25936802.	IDA	Component
GO:0005794	Golgi apparatus	8806680.	IDA	Component
GO:0005794	Golgi apparatus	10585443.	IDA	Component
GO:0005829	cytosol	10585443.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006469	negative regulation of protein kinase activity	-	ISS	Process
GO:0006606	protein import into nucleus	-	ISS	Process
GO:0006897	endocytosis	9045618.	TAS	Process
GO:0007507	heart development	-	ISS	Process
GO:0008104	protein localization	-	ISS	Process
GO:0008285	negative regulation of cell proliferation	-	ISS	Process
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	-	ISS	Process
GO:0014069	postsynaptic density	27898073.	EXP	Component
GO:0014069	postsynaptic density	27898073.	IDA	Component
GO:0016020	membrane	16636147.	IDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0016192	vesicle-mediated transport	9045618.	TAS	Process
GO:0016239	positive regulation of macroautophagy	23778976.	IGI	Process
GO:0019902	phosphatase binding	19389623.	IDA	Function
GO:0030100	regulation of endocytosis	-	ISS	Process
GO:0030178	negative regulation of Wnt signaling pathway	21873635.	IBA	Process
GO:0031267	small GTPase binding	25936802.	IPI	Function
GO:0032007	negative regulation of TOR signaling	21873635.	IBA	Process
GO:0032007	negative regulation of TOR signaling	23778976.	IGI	Process
GO:0033596	TSC1-TSC2 complex	21873635.	IBA	Component
GO:0033596	TSC1-TSC2 complex	9580671.	IDA	Component
GO:0042803	protein homodimerization activity	10585443.	IPI	Function
GO:0043276	anoikis	23778976.	IGI	Process
GO:0043491	protein kinase B signaling	-	ISS	Process
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0046626	regulation of insulin receptor signaling pathway	-	ISS	Process
GO:0046627	negative regulation of insulin receptor signaling pathway	21873635.	IBA	Process
GO:0048009	insulin-like growth factor receptor signaling pathway	-	ISS	Process
GO:0048471	perinuclear region of cytoplasm	8806680.	IDA	Component
GO:0050918	positive chemotaxis	-	ISS	Process
GO:0051056	regulation of small GTPase mediated signal transduction	-	IEA	Process
GO:0051726	regulation of cell cycle	21873635.	IBA	Process
GO:0051879	Hsp90 protein binding	29127155.	IPI	Function
GO:0051898	negative regulation of protein kinase B signaling	21873635.	IBA	Process
GO:0051898	negative regulation of protein kinase B signaling	-	ISS	Process
GO:1901525	negative regulation of mitophagy	26735435.	NAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.