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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26617887Multidrug resistance protein and topoisomerase 2 alpha expression in non-small cell lung cancer are related with brain metastasis postoperatively.Int J Clin Exp Pathol2015 Sep 1Huang H-
24024181Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma.Biomed Res Int2013Bagnoli Mdoi: 10.1155/2013/143202
17596751Clinicopathological parameters and expression of P-glycoprotein and MRP-1 in retinoblastoma.Ophthalmic Res2007Kamburolu G-
18200595Determination of P-glycoprotein, MDR-related protein 1, breast cancer resistance protein, and lung-resistance protein expression in leukemic stem cells of acute myeloid leukemia.Cytometry B Clin Cytom2008 Mayde Figueiredo-Pontes LLdoi: 10.1002/cyto.b.20403.
19883630Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1.Biochem Pharmacol2010 Mar 15Liang Zdoi: 10.1016/j.bcp.2009.10.017
21793937The expression and significance of MRP1, LRP, TOPOIIβ, and BCL2 in tongue squamous cell carcinoma.J Oral Pathol Med2012 FebZhang Bdoi: 10.1111/j.1600-0714.2011.01066.x
16278376Multidrug resistance proteins in gastrointestinal stromal tumors: site-dependent expression and initial response to imatinib.Clin Cancer Res2005 Nov 1Th??ou N-
22798502MGMT hypermethylation and MDR system in glioblastoma cancer stem cells.Cancer Genomics Proteomics2012 Jul-AugCaldera V-
28411177Expression of MRP1 and ABCG2 is associated with adverse clinical outcomes of papillary thyroid carcinoma with a solid component.Hum Pathol2017 SepOhashi Rdoi: 10.1016/j.humpath.2017.03.012
28849227Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells.Oncol Rep2017 OctGuimares LPTPdoi: 10.3892/or.2017.5895
19438741Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosis.Histopathology2009 MayFaggad Adoi: 10.1111/j.1365-2559.2009.03297.x.
27487127miR-145 sensitizes breast cancer to doxorubicin by targeting multidrug resistance-associated protein-1.Oncotarget2016 Sep 13Gao Mdoi: 10.18632/oncotarget.10845.
27689338Promoter methylation patterns of ABCB1, ABCC1 and ABCG2 in human cancer cell lines, multidrug-resistant cell models and tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients.Oncotarget2016 Nov 8Spitzwieser Mdoi: 10.18632/oncotarget.12332.
21736601ABCC1 polymorphism Arg723Gln (2168G> A) is associated with lung cancer susceptibility in a Chinese population.Clin Exp Pharmacol Physiol2011 SepYin JYdoi: 10.1111/j.1440-1681.2011.05571.x.
26852750miR-145 sensitizes gallbladder cancer to cisplatin by regulating multidrug resistance associated protein 1.Tumour Biol2016 AugZhan Mdoi: 10.1007/s13277-016-4957-6
27033456The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters.Cancer Lett2016 Jun 28Rigalli JPdoi: 10.1016/j.canlet.2016.03.040
19107762Genetic susceptibility of lung cancer associated with common variants in the 3' untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export.Cancer2009 Feb 1Wang Hdoi: 10.1002/cncr.24042.
26108539miR-7 modulates chemoresistance of small cell lung cancer by repressing MRP1/ABCC1.Int J Exp Pathol2015 AugLiu Hdoi: 10.1111/iep.12131
22117969Lung resistance protein and multidrug resistance protein in non-small cell lung cancer and their clinical significance.J Int Med Res2011Chen ZJ-
26031227MRP1 expression in bronchoalveolar lavage cells in subjects with lung cancer who were chronically exposed to arsenic.Environ Mol Mutagen2015 DecRecio-Vega Rdoi: 10.1002/em.21960
18702307[Role of PTEN protein in multidrug resistance of prostate cancer cells].Mol Biol (Mosk)2008 May-JunSherbakova EA-
21956451Expression and promoter methylation analysis of ATP-binding cassette genes in pancreatic cancer.Oncol Rep2012 JanChen Mdoi: 10.3892/or.2011.1475
22143792Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells.Proc Natl Acad Sci U S A2011 Dec 20Cho Sdoi: 10.1073/pnas.1019452108
20233511Expression of P-glycoprotein and multidrug resistance-associated protein is associated with multidrug resistance in gastric cancer.J Int Med Res2010 Jan-FebXu HW-
17606722Multidrug resistance proteins do not predict benefit of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer: International Adjuvant Lung Cancer Trial Biologic Program.Clin Cancer Res2007 Jul 1Filipits M-
17033200Multidrug resistance in locally advanced breast cancer.Tumour Biol2006Atalay C-
19622290[Correlation of chemosensitivity measured by histoculture drug response assay to expression of multidrug resistance genes and proteins in gastric cancer].Ai Zheng2009 AprYuan SQ-
18204073Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane.Carcinogenesis2008 AprSibhatu MBdoi: 10.1093/carcin/bgn013
19513507The overexpression of multidrug resistance-associated proteins and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells.Oncol Rep2009 JulChen X-
27706681Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.Genet Mol Res2016 Sep 2Jiang YQdoi: 10.4238/gmr.15038336.
18690847Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy.Curr Cancer Drug Targets2008 AugGradilone A-
25078270Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer.PLoS One2014 Jul 31Kunick?? Tdoi: 10.1371/journal.pone.0101740
16410721CIAPIN1 confers multidrug resistance by upregulating the expression of MDR-1 and MRP-1 in gastric cancer cells.Cancer Biol Ther2006 MarHao Z-
19129072Role of ABCB1 and ABCC1 gene induction on survival in locally advanced breast cancer.J Chemother2008 DecAtalay C-
12576456RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response.Clin Cancer Res2003 FebBurger H-
25564970Time and concentration dependency of P-gp, MRP1 and MRP5 induction in response to gemcitabine uptake in Capan-2 pancreatic cancer cells.Xenobiotica2015Kohan HGdoi: 10.3109/00498254.2014.1001809
19875192Association of expression of MRP1, BCRP, LRP and ERCC1 with outcome of patients with locally advanced non-small cell lung cancer who received neoadjuvant chemotherapy.Lung Cancer2010 JulLi Jdoi: 10.1016/j.lungcan.2009.09.013
17203221Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines.Int J Oncol2007 FebNaramoto H-
25605145RNAi-based knockdown of multidrug resistance-associated protein 1 is sufficient to reverse multidrug resistance of human lung cells.Asian Pac J Cancer Prev2014Shao SL-
15856298Multidrug resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer: prognostic implications.J Cancer Res Clin Oncol2005 JunBerger W-
25550836Significance of multidrug resistance gene-related proteins in the postoperative chemotherapy of gastric cancer.Int J Clin Exp Pathol2014 Oct 15Yu P-
25885226Decreased functional activity of multidrug resistance protein in primary colorectal cancer.Diagn Pathol2015 Apr 16Micsik Tdoi: 10.1186/s13000-015-0264-6.
26600514Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells.Genet Mol Res2015 Nov 19Chen SFdoi: 10.4238/2015.November.18.18.
28762597Visfatin mediates doxorubicin resistance in human non-small-cell lung cancer via Akt-mediated up-regulation of ABCC1.Cell Prolif2017 OctCao Zdoi: 10.1111/cpr.12366
27739315[Expression of ATP-binding Cassette Proteins Pgp, MRP1, and MRP3 in Malignant and Benign Ovarian Lesions].Klin OnkolFall 2016Sedl??kov?? I-
28499449PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy.Mol Cancer2017 May 12Salaroglio ICdoi: 10.1186/s12943-017-0657-0.
27878697NF??BP65 transcription factor modulates resistance to doxorubicin through ABC transporters in breast cancer.Breast Cancer2017 JulVelaei Kdoi: 10.1007/s12282-016-0738-8
29080842Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells.Free Radic Biol Med2017 DecChen HHdoi: 10.1016/j.freeradbiomed.2017.10.375
30132569Clinical relevance of the multidrug resistanceassociated protein1 gene in nonsmall cell lung cancer: A systematic review and metaanalysis.Oncol Rep2018 NovHu Pdoi: 10.3892/or.2018.6652
30257334KDM5c inhibits multidrug resistance of colon cancer cell line by down-regulating ABCC1.Biomed Pharmacother2018 NovLin Hdoi: 10.1016/j.biopha.2018.08.041
29548748Knockdown of MALAT1 enhances chemosensitivity of ovarian cancer cells to cisplatin through inhibiting the Notch1 signaling pathway.Exp Cell Res2018 May 15Bai Ldoi: 10.1016/j.yexcr.2018.03.014
30486550Expression of LRP Gene in Breast Cancer Patients Correlated with MRP1 as Two Independent Predictive Biomarkers in Breast CancerAsian Pac J Cancer Prev2018 Nov 29Taheri M-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1616090525Missense_Mutationrs45517537A861T0.87
BLCAchr1616045890Missense_MutationnovelF365L0.21
BLCAchr1616009886SilentNAL112L0.23
BLCAchr1616090484Missense_MutationnovelS847C0.28
BLCAchr1616125895Missense_MutationNAS1268L0.12
BLCAchr1616138431Missense_MutationNAD1454N0.23
BLCAchr1616009895Missense_MutationNAI115M0.2
BLCAchr1616036529SilentNAN245N0.47
BLCAchr1616045932Silentrs528197968L379L0.21
BLCAchr1616136508Missense_MutationNAM1386V0.35
BLCAchr1616114968SilentNAF1094F0.29
BLCAchr1616090501Nonsense_MutationNAQ853*0.2
BLCAchr1616114968SilentNAF1094F0.17
BLCAchr1616086912Missense_MutationNAP794L0.22
BLCAchr1616121991Missense_MutationnovelS1136F0.33
BLCAchr1616016555SilentNAL183L0.17
BLCAchr1616044476Missense_Mutationrs775434031S279F0.15
BLCAchr1616114919Missense_MutationnovelK1078M0.09
BLCAchr1616086911Missense_MutationNAP794S0.1
BLCAchr1616122070SilentNAV1162V0.2
BRCAchr1616052733Missense_MutationNAP464A0.38
BRCAchr1616056276Nonsense_MutationnovelW553*0.32
BRCAchr1616134468Missense_MutationnovelG1362D0.32
BRCAchr1616056217SilentNAQ533Q0.23
BRCAchr1616114947SilentNAI1087I0.11
BRCAchr1616056282Missense_MutationnovelC555F0.08
BRCAchr1616014493Splice_RegionnovelL118L0.08
BRCAchr1616007881SilentNAL38L0.42
BRCAchr1616046002Missense_MutationNAV403F0.23
BRCAchr1616125873Missense_Mutationrs756405833V1261M0.38
BRCAchr1616106774SilentNAI924I0.13
BRCAchr1616056286Silentrs763358768T556T0.31
BRCAchr1616124820Missense_MutationNAN1208D0.13
BRCAchr1616014556Silentrs372930912L139L0.26
BRCAchr1616044510Missense_Mutationrs377634982K290N0.06
CESCchr1616068227SilentNAF583F0.27
CESCchr1616136642Splice_RegionnovelL1430L0.37
CESCchr1616086904Silentrs748257791F791F0.23
CESCchr1616056106Missense_MutationnovelK496N0.56
CESCchr1616044469Missense_MutationNAY277H0.36
CESCchr1616071711Nonsense_MutationnovelR632*0.16
CESCchr1616138415Silentrs36115566T1448T0.42
CESCchr1616141213Missense_Mutationrs764004869A1510T0.48
CESCchr1616086859SilentnovelV776V0.3
CESCchr1616136538Missense_MutationnovelD1396H0.13
CESCchr1616036491Missense_Mutationrs753693807R233C0.2
CESCchr1616014488Splice_Regionnovel0.2
CESCchr1616036553SilentnovelV253V0.39
CHOLchr1616086827Missense_MutationnovelV766M0.23
COADchr1616079406SilentnovelG681G0.09
COADchr1616056120Missense_MutationNAR501Q0.41
COADchr1616068195Missense_Mutationrs751292519E573K0.34
COADchr1616068275SilentNAL599L0.15
COADchr1616111382Missense_MutationnovelL960R0.2
COADchr1616115018Missense_MutationnovelA1111D0.1
COADchr1616111461Silentrs45607431H986H0.16
COADchr1616068209SilentnovelL577L0.07
COADchr1616048180SilentNAT419T0.36
COADchr1616048213Silentrs371886235D430D0.17
COADchr1616141258Missense_MutationNAA1525T0.41
COADchr1616016541Frame_Shift_DelnovelS180Pfs*480.24
COADchr1616131817Missense_Mutationrs765498811P1283L0.23
COADchr1616114895Missense_MutationnovelG1070E0.07
COADchr1616106861Silentrs372453304A953A0.37
COADchr1616141214Frame_Shift_DelnovelP1511Hfs*540.34
COADchr1616106796Missense_Mutationrs768011444A932T0.51
COADchr1616136537Silentrs200975492S1395S0.44
COADchr1616045897Missense_Mutationrs200520366V368M0.32
COADchr1616131925Missense_MutationNAG1319V0.35
COADchr1616106861Silentrs372453304A953A0.42
COADchr1616124906Nonsense_MutationNAY1236*0.22
COADchr1616090406Missense_MutationNAT821M0.1
COADchr1616079410Missense_Mutationrs766665700G683R0.39
COADchr1616106797Missense_Mutationrs375097324A932V0.25
COADchr1616044589Missense_MutationNAL317V0.36
COADchr1616102633Missense_Mutationrs751066573T884M0.16
COADchr16161412843'UTRnovel0.24
COADchr1616122031SilentNAS1149S0.22
COADchr1616122133Silentrs759822263D1183D0.2
COADchr1616056269Missense_MutationNAF551V0.34
COADchr1616111539SilentNAT1012T0.15
COADchr1616124875Missense_MutationNAS1226N0.23
COADchr1616071660In_Frame_InsNAR615delinsLS0.33
COADchr1616044623Missense_MutationnovelS328N0.29
COADchr1616141207Missense_MutationnovelY1508H0.39
COADchr1616090525Missense_Mutationrs45517537A861T0.24
COADchr1616136485Missense_MutationNAV1378A0.33
COADchr1616076335Missense_Mutationrs756498834T641M0.13
COADchr1616071683SilentNAH622H0.19
COADchr1616114843SilentNAL1053L0.27
DLBCchr1616052728Missense_MutationnovelL462P0.41
DLBCchr1616068303Splice_SitenovelX608_splice0.64
ESCAchr1616068169Missense_MutationnovelT564I0.07
ESCAchr1616083498SilentnovelL750L0.12
GBMchr1616122025SilentNAS1147S0.13
GBMchr1616052768SilentnovelL475L0.08
GBMchr1616007904Missense_MutationnovelL46P0.07
GBMchr1616106811Missense_MutationnovelA937P0.1
GBMchr1616009782Nonsense_MutationnovelG78*0.23
GBMchr1616111539SilentNAT1012T0.13
GBMchr1616134352Splice_Regionrs759266398V1323V0.21
GBMchr1616083508Missense_MutationnovelL753R0.12
GBMchr1616086872Missense_MutationnovelA781P0.07
GBMchr1616056200Missense_MutationnovelV528L0.21
GBMchr1616036542Missense_MutationnovelS250P0.18
GBMchr1616048178Missense_MutationnovelT419S0.06
GBMchr1616114874Missense_MutationnovelF1063S0.18
GBMchr1616044558SilentnovelQ306Q0.41
GBMchr1616068228Missense_Mutationrs368340485V584M0.09
GBMchr1616111509Frame_Shift_InsnovelP1003Tfs*630.15
GBMchr1616124801SilentNAV1201V0.26
GBMchr1616036527Missense_MutationnovelN245Y0.18
GBMchr1616138506Missense_MutationnovelC1479S0.2
GBMchr1616009827Missense_MutationnovelF93L0.19
HNSCchr1616007905SilentnovelL46L0.08
HNSCchr1616122014Missense_MutationNAE1144K0.31
HNSCchr1616124860Missense_MutationnovelS1221F0.38
HNSCchr1616124861SilentnovelS1221S0.38
HNSCchr1616090452Silentrs374092475D836D0.11
HNSCchr1616122160SilentnovelS1192S0.34
HNSCchr1616009817SilentnovelL89L0.13
HNSCchr1616111449Silentrs376870080F982F0.09
HNSCchr1616052780SilentnovelV479V0.11
HNSCchr1616138415Silentrs36115566T1448T0.16
HNSCchr1616114843Missense_MutationnovelL1053M0.24
HNSCchr1616048303Splice_RegionnovelL460L0.2
HNSCchr1616111539SilentNAT1012T0.38
HNSCchr1616068189Missense_MutationnovelI571V0.16
HNSCchr1616083506SilentnovelI752I0.16
KIRCchr1616131935Splice_SitenovelX1322_splice0.5
KIRCchr1616056120Missense_MutationNAR501Q0.26
KIRCchr1616014619SilentNAA160A0.23
KIRPchr1616134366Missense_Mutationrs370672850R1328Q0.16
KIRPchr1616122052Silentrs766636573N1156N0.55
KIRPchr1616086839Missense_MutationNAG770R0.15
KIRPchr1616083501Missense_MutationNAE751K0.21
LGGchr1616056194Missense_MutationnovelD526H0.42
LGGchr1616007933Missense_MutationnovelY56H0.36
LGGchr1616052739Missense_Mutationrs768562502V466I0.52
LGGchr1616122074Missense_Mutationrs202134920V1164I0.46
LGGchr1616131935Missense_MutationnovelK1322N0.39
LIHCchr1616083531Missense_MutationnovelI761F0.2
LIHCchr1616083445Missense_MutationnovelL732Q0.3
LIHCchr1616044494Missense_MutationnovelP285Q0.19
LIHCchr1616090456Missense_Mutationrs780819239I838V0.34
LIHCchr1616045947SilentNAY384Y0.13
LUADchr1616016535Missense_Mutationrs201215222V177I0.06
LUADchr1616131905Silentrs369198761H1312H0.11
LUADchr1616124810Missense_MutationNAE1204D0.27
LUADchr1616036541SilentNAT249T0.33
LUADchr1616056150Missense_MutationNAG511V0.2
LUADchr1616068279Missense_MutationNAM601V0.08
LUADchr1616052810SilentNAT489T0.4
LUADchr1616115006Missense_MutationNAV1107A0.12
LUADchr1616122080Nonsense_Mutationrs368794890R1166*0.08
LUADchr1616086871SilentnovelR780R0.28
LUADchr1616016534Silentrs200973377Y176Y0.1
LUADchr1616079475SilentnovelI704I0.14
LUADchr1616122069Missense_MutationnovelV1162A0.29
LUADchr1616083412Missense_MutationnovelS721C0.19
LUADchr1616079377Missense_MutationnovelA672T0.32
LUADchr1616131812SilentnovelT1281T0.15
LUADchr16161413633'UTRnovel0.29
LUADchr1616079411Missense_MutationnovelG683E0.43
LUADchr1616114891Missense_MutationnovelS1069C0.08
LUADchr1616083538In_Frame_DelnovelK764del0.11
LUADchr1616090491Missense_MutationNAM849I0.47
LUSCchr1616090525Missense_Mutationrs45517537A861T0.22
LUSCchr1616124886Missense_MutationnovelV1230L0.28
LUSCchr1616086863Missense_MutationnovelL778V0.18
LUSCchr1616009817SilentNAL89L0.08
LUSCchr1616090449SilentnovelV835V0.22
LUSCchr1616138367Silentrs753509205V1432V0.21
LUSCchr1616056211SilentnovelI531I0.18
LUSCchr1616115071Missense_Mutationrs74985930V1129I0.45
LUSCchr1616114771Missense_MutationNAA1029T0.27
LUSCchr1616016590Missense_MutationNAS195L0.24
LUSCchr1616076377Missense_MutationNAR655M0.28
LUSCchr1616083398Frame_Shift_DelnovelQ718Lfs*200.09
LUSCchr1616052804SilentNAT487T0.23
LUSCchr1616071671Missense_MutationnovelI618M0.27
LUSCchr1616079400SilentnovelQ679Q0.21
LUSCchr1616014592SilentNAA151A0.25
LUSCchr1616125812Splice_RegionNAV1240V0.13
LUSCchr1616111422Missense_MutationNAF973L0.17
OVchr1616124838Missense_MutationnovelA1214S0.16
OVchr1616036583SilentnovelK263K0.03
OVchr1616122128Missense_MutationnovelV1182L0.11
OVchr1616134409SilentnovelR1342R0.09
OVchr1616079462Missense_MutationNAG700A0.17
OVchr1616115010Frame_Shift_InsnovelL1109Tfs*710.1
OVchr1616114815SilentNAL1043L0.54
OVchr1616114955Missense_MutationnovelV1090D0.11
OVchr1616141266Frame_Shift_DelnovelD1527Efs*380.07
OVchr16161413573'UTRnovel0.1
OVchr16161413983'UTRnovel0.09
OVchr1616048263Frame_Shift_DelnovelL449Cfs*120.08
OVchr1616111464SilentNAV987V0.19
OVchr1616138434Missense_MutationnovelE1455Q0.24
OVchr1616056358Intronnovel0.08
OVchr1616114822Missense_Mutationrs376107020R1046C0.34
OVchr1616068209SilentnovelL577L0.03
OVchr1616141217Missense_MutationnovelP1511L0.04
OVchr1616114807Missense_MutationnovelG1041R0.13
OVchr1616102675Missense_Mutationrs762722945N898S0.69
PAADchr1616056273Missense_MutationnovelT552I0.2
PRADchr1616122014Missense_MutationNAE1144K0.26
READchr1616122150Missense_MutationNAY1189C0.21
READchr1616068177Missense_Mutationrs545772203V567I0.28
READchr1616048239Missense_MutationNAT439R0.18
READchr1616044668Missense_Mutationrs749166736P343L0.08
READchr1616138442Silentrs202222707T1457T0.31
READchr1616115029Missense_Mutationrs371062976A1115T0.5
READchr1616134407Missense_Mutationrs201020041R1342W0.26
READchr1616016558Missense_MutationnovelI184M0.11
READchr1616044519SilentNAA293A0.29
SARCchr1616111387Missense_Mutationrs371105838V962M0.11
SARCchr16161413903'UTRnovel0.2
SARCchr1616086949SilentnovelI806I0.35
SKCMchr1616048266Missense_MutationnovelP448L0.19
SKCMchr1616048267Silentrs770162860P448P0.19
SKCMchr1616138483Missense_MutationnovelT1471I0.54
SKCMchr1616138484Silentrs765042675T1471T0.54
SKCMchr1616033112Missense_MutationnovelP207S0.13
SKCMchr1616056289SilentnovelP557P0.49
SKCMchr1616056316Intronnovel0.53
SKCMchr1616068227SilentNAF583F0.43
SKCMchr1616033113Missense_MutationNAP207L0.16
SKCMchr1616044543Silentrs371536692I301I0.28
SKCMchr1616111385Missense_MutationNAS961F0.27
SKCMchr1616136494Missense_Mutationrs574461562S1381L0.18
SKCMchr1616131893Silentrs201117375F1308F0.81
SKCMchr1616083491SilentNAL747L0.5
SKCMchr1616044494Missense_Mutationrs199675371P285L0.1
SKCMchr1616138400SilentnovelA1443A0.18
SKCMchr1616068245SilentNAF589F0.16
SKCMchr1616083371Silentrs778317375S707S0.35
SKCMchr1616122109SilentNAI1175I0.17
SKCMchr1616045896Silentrs757411793T367T0.18
SKCMchr1616083386SilentNAP712P0.26
SKCMchr1616079417Missense_MutationNAS685L0.31
SKCMchr1616106752Missense_MutationNAS917F0.24
SKCMchr1616122037SilentNAV1151V0.21
SKCMchr1616007815Splice_SiteNAX17_splice0.33
SKCMchr1616007816Missense_Mutationrs761719926D17Y0.36
SKCMchr1616134407Missense_Mutationrs201020041R1342W0.34
SKCMchr1616136505Nonsense_MutationNAR1385*0.3
SKCMchr1616056316Intronnovel0.37
SKCMchr1616044600SilentNAT320T0.34
SKCMchr1616036499SilentNAP235P0.17
SKCMchr1616014628Splice_RegionnovelE163E0.36
SKCMchr1616079397SilentnovelG678G0.42
SKCMchr1616016542Missense_MutationNAF179Y0.18
SKCMchr1616044615SilentNAF325F0.15
SKCMchr1616131936Splice_SiteNAX1322_splice0.2
SKCMchr1616083398Nonsense_MutationNAW716*0.33
SKCMchr1616121992Silentrs755141356S1136S0.35
SKCMchr1616056316Intronnovel0.24
SKCMchr1616122088Silentrs372721973F1168F0.12
SKCMchr1616016559Nonsense_MutationNAQ185*0.2
SKCMchr1616016517Missense_Mutationrs775155522R171C0.41
SKCMchr1616086825Missense_MutationnovelG765D0.43
SKCMchr1616016517Missense_Mutationrs775155522R171C0.13
SKCMchr1616111415Missense_MutationNAG971E0.4
SKCMchr1616083522Missense_Mutationrs763841979R758W0.41
SKCMchr1616111386Silentrs769381562S961S0.32
SKCMchr1616111577Missense_MutationNAS1025L0.43
SKCMchr1616134487Silentrs376860266F1368F0.32
STADchr1616122034Silentrs4148377P1150P0.3
STADchr1616036482Missense_Mutationrs200485505R230W0.31
STADchr1616106758Missense_MutationNAS919Y0.38
STADchr1616014596Missense_MutationNAL153M0.22
STADchr1616044669Silentrs568658348P343P0.4
STADchr1616141213Missense_Mutationrs764004869A1510T0.17
STADchr1616071729Frame_Shift_Insrs7633579380.43
STADchr1616141267Missense_Mutationrs377013600A1528T0.37
STADchr1616138375Missense_MutationNAR1435H0.41
STADchr16161412903'UTRnovel0.43
STADchr1616046013Splice_RegionNAK406K0.09
STADchr1616115022Silentrs767072123T1112T0.09
STADchr1616007917Frame_Shift_DelNAF52Sfs*160.12
STADchr1616068194Silentrs766460837D572D0.2
STADchr1616033135SilentNAS214S0.21
STADchr1616131790Missense_Mutationrs746483854A1274V0.45
STADchr1616098889Intronrs1819406600.13
STADchr1616131817Missense_Mutationrs765498811P1283L0.29
STADchr1616048262Frame_Shift_InsnovelL449Pfs*1240.46
STADchr1616048262Frame_Shift_InsnovelL449Pfs*1240.16
STADchr1616124793SilentNAL1199L0.13
STADchr1616052785Missense_MutationNAA481D0.21
STADchr1616138394SilentnovelA1441A0.27
STADchr1616111431Missense_MutationNAF976L0.24
STADchr1616090453Missense_Mutationrs754975789V837I0.18
STADchr1616131818Silentrs372055534P1283P0.28
STADchr1616007895Frame_Shift_InsnovelY45Lfs*170.08
TGCTchr1616131854Missense_MutationnovelF1295L0.1
THYMchr1616114823Missense_Mutationrs761512468R1046H0.12
UCECchr1616124890Missense_MutationnovelG1231D0.32
UCECchr1616048236Missense_MutationnovelA438V0.3
UCECchr1616014626Nonsense_MutationNAE163*0.33
UCECchr1616036571Silentrs148057395K259K0.28
UCECchr1616134457Silentrs769980148I1358I0.34
UCECchr1616036535Missense_MutationnovelE247D0.22
UCECchr1616138490SilentNAR1473R0.31
UCECchr1616071644Splice_Regionrs758909835A609A0.41
UCECchr1616114779SilentnovelF1031F0.06
UCECchr1616138449Missense_Mutationrs749468738V1460M0.34
UCECchr1616009822Missense_Mutationrs757068084Y91C0.19
UCECchr1616048149Missense_MutationnovelV409A0.08
UCECchr1616079431Missense_MutationnovelA690S0.45
UCECchr1616083406Missense_MutationnovelN719T0.44
UCECchr1616134465Missense_MutationnovelI1361T0.5
UCECchr1616033169Missense_MutationnovelG226W0.5
UCECchr1616045858Missense_MutationnovelD355Y0.48
UCECchr1616044469Missense_MutationNAY277H0.47
UCECchr1616124915Missense_Mutationrs748378518Q1239H0.36
UCECchr1616016587Missense_MutationnovelR194H0.08
UCECchr1616076336SilentnovelT641T0.44
UCECchr1616007881Silentrs745945401L38L0.38
UCECchr1616056137Missense_MutationNAE507K0.37
UCECchr1616111488Nonsense_MutationnovelW995*0.39
UCECchr1616136537Silentrs200975492S1395S0.41
UCECchr1616036544Silentrs201310614S250S0.21
UCECchr1616045963Missense_Mutationrs754876461V390I0.1
UCECchr1616016518Missense_Mutationrs559703047R171H0.39
UCECchr1616045987Missense_MutationNAA398T0.26
UCECchr1616090569Missense_MutationNAE875D0.29
UCECchr1616122014Missense_MutationNAE1144K0.23
UCECchr1616138541In_Frame_InsnovelT1490_I1491insYNL0.09
UCECchr1616115054Missense_Mutationrs770719562G1123D0.13
UCECchr16161412903'UTRnovel0.3
UCECchr1616111566SilentnovelA1021A0.32
UCECchr1616090474Missense_Mutationrs186193767G844S0.16
UCECchr1616071690Missense_MutationNAL625M0.19
UCECchr16161414373'UTRnovel0.56
UCECchr1616014597Missense_MutationNAL153P0.2
UCECchr1616068229Missense_MutationnovelV584A0.27
UCECchr1616086857Missense_Mutationrs763781150V776M0.25
UCECchr1616114834Missense_MutationnovelV1050M0.37
UCECchr1616007952Missense_Mutationrs187769078R62Q0.23
UCECchr1616045881Missense_MutationnovelQ362H0.17
UCECchr1616071694Missense_MutationnovelE626G0.25
UCECchr1616122027Missense_Mutationrs748686682R1148H0.12
UCECchr16161417633'UTRrs3765733390.25
UCECchr1616007975Missense_MutationnovelL70V0.12
UCECchr1616131843Nonsense_Mutationrs374116688R1292*0.41
UCECchr1616044532Missense_MutationnovelE298K0.33
UCECchr1616056137Missense_MutationNAE507K0.29
UCECchr1616136505Nonsense_MutationNAR1385*0.42
UCECchr1616016603Silentrs761393295S199S0.53
UCECchr1616115029Missense_Mutationrs371062976A1115T0.44
UCECchr1616138415Silentrs36115566T1448T0.29
UCECchr1616068241Nonsense_MutationnovelL588*0.53
UCECchr1616090453Missense_Mutationrs754975789V837I0.41
UCECchr16161413443'UTRnovel0.28
UCECchr1616007848Silentrs375663357P27P0.53
UCECchr1616131832Missense_MutationnovelP1288H0.37
UCECchr1616141183SilentnovelL1500L0.38
UCECchr1616007829Missense_Mutationrs762542019T21M0.2
UCECchr1616036544Silentrs201310614S250S0.35
UCECchr1616102719Splice_SitenovelX912_splice0.41
UCECchr1616134458Missense_Mutationrs779040246A1359T0.11
UCECchr16161429343'UTRnovel0.41
UCECchr1616106799Nonsense_MutationnovelE933*0.42
UCECchr1616134359Missense_MutationnovelV1326M0.26
UCECchr1616083371Silentrs778317375S707S0.35
UCECchr1616115047Missense_MutationnovelP1121S0.41
UCECchr1616014626Missense_MutationnovelE163K0.32
UCECchr1616036590Missense_Mutationrs758046256A266T0.36
UCECchr1616045866Missense_MutationnovelK357N0.43
UCECchr1616048240Silentrs776862356T439T0.28
UCECchr1616007942Nonsense_Mutationrs768037858R59*0.42
UCECchr1616111414Missense_MutationnovelG971R0.39
UCECchr1616014624Missense_MutationnovelK162T0.91
UCECchr1616044543Silentrs371536692I301I0.85
UCECchr1616083522Missense_Mutationrs763841979R758W0.88
UCECchr1616115029Missense_Mutationrs371062976A1115T0.83
UCECchr1616138499Silentrs765994841F1476F0.92
UCECchr1616115046Silentrs748005412P1120P0.49
UCECchr1616056102Missense_MutationNAM495T0.27
UCECchr1616036507Missense_MutationNAG238D0.26
UCECchr1616014618Missense_Mutationrs746254153A160V0.18
UCECchr1616056217SilentNAQ533Q0.33
UCECchr1616086857Missense_Mutationrs763781150V776M0.2
UCECchr1616090544Missense_Mutationrs778539912R867H0.37
UCECchr1616122091Missense_MutationnovelE1169D0.41
UCECchr1616124824Missense_MutationNAC1209Y0.25
UCECchr1616090524Silentrs367802550G860G0.21
UCECchr1616056316Intronnovel0.09
UCECchr1616068296Silentrs776825129I606I0.34
UCECchr1616083504Missense_MutationNAI752L0.33
UCECchr1616009782Missense_MutationnovelG78R0.25
UCECchr1616048184Missense_Mutationrs763651349G421R0.43
UCECchr1616052810Silentrs566325824T489T0.44
UCECchr1616086856Silentrs544129742R775R0.23
UCECchr1616106796Missense_Mutationrs768011444A932T0.53
UCECchr1616111414Missense_MutationnovelG971R0.48
UCECchr1616114771Missense_MutationNAA1029T0.37
UCECchr1616122008Missense_MutationnovelR1142C0.38
UCECchr1616131927Missense_MutationnovelG1320R0.53
UCECchr1616076357Missense_MutationnovelN648K0.43
UCECchr1616079431Missense_MutationnovelA690T0.43
UCECchr1616122069Missense_MutationnovelV1162G0.46
UCECchr1616134416Missense_MutationnovelE1345K0.33
UCECchr1616044495Silentrs587783372P285P0.3
UCECchr1616086863Missense_MutationnovelL778M0.43
UCECchr1616111489Missense_MutationnovelL996F0.07
UCSchr1616056101Missense_Mutationrs777074835M495V0.22
UCSchr1616014548Missense_Mutationrs766226776I137V0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CHOLDEL0.11110.23475

Survival Analysis
CancerP-value Q-value
THYM0.022

Kaplan-Meier Survival Analysis

KIRC0.027

Kaplan-Meier Survival Analysis

MESO0.0012

Kaplan-Meier Survival Analysis

UCS0.0063

Kaplan-Meier Survival Analysis

SKCM0.0024

Kaplan-Meier Survival Analysis

LUSC0.037

Kaplan-Meier Survival Analysis

KIRP0.0039

Kaplan-Meier Survival Analysis

PAAD0.011

Kaplan-Meier Survival Analysis

READ0.012

Kaplan-Meier Survival Analysis

LIHC0.00014

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

THCA0.017

Kaplan-Meier Survival Analysis

UVM0.00022

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000103222 (Gene tree)
Gene ID
4363
Gene Symbol
ABCC1
Alias
GS-X|MRP|MRP1
Full Name
ATP binding cassette subfamily C member 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
193,498 bases
Position
chr16:15,949,577-16,143,074
Accession
51
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15504736RNA interference analyses suggest a transcript-specific regulatory role for mitochondrial RNA-binding proteins MRP1 and MRP2 in RNA editing and other RNA processing in Trypanosoma brucei.J Biol Chem2005 Jan 28Vondruskova E-
16730807The effect of down-regulation of mitochondrial RNA-binding proteins MRP1 and MRP2 on respiratory complexes in procyclic Trypanosoma brucei.Mol Biochem Parasitol2006 SepZikova A-
23746168Structure prediction of gBP21 protein of L. donovani and its molecular interaction.J Biomol Struct Dyn2014Sahoo GCdoi: 10.1080/07391102.2013.789400
16923390Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism.Cell2006 Aug 25Schumacher MA-
9166399The dynamic organization of the perinucleolar compartment in the cell nucleus.J Cell Biol1997 Jun 2Huang S-
22840641The role of several ABC transporter genes in ivermectin resistance in Caenorhabditis elegans.Vet Parasitol2012 Dec 21Yan Rdoi: 10.1016/j.vetpar.2012.06.038
27092478Pharmacogenomics of Scopoletin in Tumor Cells.Molecules2016 Apr 15Seo EJdoi: 10.3390/molecules21040496.
29726910Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival.Carcinogenesis2018 Jul 3Freedman JAdoi: 10.1093/carcin/bgy062.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000575422ABCC1-2071198--- (aa)--
ENST00000576557ABCC1-208542--- (aa)--
ENST00000399410ABCC1-2026552XM_011522497ENSP000003823421531 (aa)XP_011520799P33527
ENST00000572053ABCC1-203744-ENSP0000045969322 (aa)-I3L2H9
ENST00000574761ABCC1-206996--- (aa)--
ENST00000572882ABCC1-2044565-ENSP000004616151440 (aa)-I3L4X2
ENST00000399408ABCC1-2016594-ENSP000003823401215 (aa)-A0A0A0MS99
ENST00000574224ABCC1-2051543--- (aa)--
Gene Model
Click here to download ENSG00000103222's gene model file
Pathways
Pathway IDPathway NameSource
hsa01523Antifolate resistanceKEGG
hsa02010ABC transportersKEGG
hsa04071Sphingolipid signaling pathwayKEGG
hsa04977Vitamin digestion and absorptionKEGG
hsa05206MicroRNAs in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000103222Antihypertensive Agents9.4790000E-005-
ENSG00000103222Blood Pressure6.9696923E-005-
ENSG00000103222Platelet Function Tests1.1278571E-006-
ENSG00000103222Platelet Function Tests5.4908429E-009-
ENSG00000103222Platelet Function Tests1.7966147E-008-
ENSG00000103222Platelet Function Tests4.3986517E-009-
ENSG00000103222Platelet Function Tests1.3296790E-008-
ENSG00000103222Platelet Function Tests5.4908429E-009-
ENSG00000103222Platelet Function Tests1.7966147E-008-
ENSG00000103222Leptin8.9040000E-005-
ENSG00000103222Venous Thromboembolism6E-628203683
ENSG00000103222Metabolism2E-1924816252
ENSG00000103222Metabolism3E-1424816252
ENSG00000103222Metabolism1E-2524816252
ENSG00000103222Metabolism6E-1324816252
ENSG00000103222Stroke5E-1126708676
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000103222rs99314871616110965?Psychosis proneness (perceptual aberration scale)28525603EFO_0008337
ENSG00000103222rs20625411616033378ABlood metabolite ratios24816252[0.014-0.022] unit decrease0.018EFO_0005664
ENSG00000103222rs744759351615961249GIschemic stroke (undetermined subtype)26708676[2.77-7.72]4.63HP_0002140
ENSG00000103222rs9241351616029602ABlood metabolite levels24816252[0.013-0.021] unit decrease0.017EFO_0005664
ENSG00000103222rs2462341616034885CBlood metabolite levels24816252[0.014-0.026] unit decrease0.02EFO_0005664
ENSG00000103222rs20625411616033378ABlood metabolite levels24816252[0.014-0.026] unit increase0.02EFO_0005664
ENSG00000103222rs9241351616029602TWhite blood cell count (basophil)27863252[0.016-0.03] unit decrease0.02315483EFO_0005090
ENSG00000103222rs2150881615971544AVenous thromboembolism adjusted for sickle cell variant rs77121243-T28203683[1.232-1.697]1.446EFO_0004286
ENSG00000103222rs1659751616040137?Mean corpuscular hemoglobin30595370EFO_0004527
ENSG00000103222rs172647361616022699?Red cell distribution width30595370EFO_0005192
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000103222's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004012phospholipid-translocating ATPase activity17050692.IMPFunction
GO:0005215transporter activity1360704.TASFunction
GO:0005524ATP binding-IEAFunction
GO:0005774vacuolar membrane21873635.IBAComponent
GO:0005886plasma membrane17050692.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0005887integral component of plasma membrane-IEAComponent
GO:0006691leukotriene metabolic process-TASProcess
GO:0006855drug transmembrane transport21873635.IBAProcess
GO:0008559xenobiotic transmembrane transporting ATPase activity21873635.IBAFunction
GO:0009235cobalamin metabolic process-TASProcess
GO:0015420cobalamin-transporting ATPase activity-TASFunction
GO:0015889cobalamin transport-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016020membrane21873635.IBAComponent
GO:0016323basolateral plasma membrane21873635.IBAComponent
GO:0016323basolateral plasma membrane24130369.IDAComponent
GO:0016887ATPase activity15999530.IDAFunction
GO:0034634glutathione transmembrane transporter activity21873635.IBAFunction
GO:0034775glutathione transmembrane transport21873635.IBAProcess
GO:0042493response to drug1360704.TASProcess
GO:0042626ATPase activity, coupled to transmembrane movement of substances21873635.IBAFunction
GO:0042626ATPase activity, coupled to transmembrane movement of substances-TASFunction
GO:0042908xenobiotic transport21873635.IBAProcess
GO:0045332phospholipid translocation17050692.IMPProcess
GO:0046623sphingolipid-translocating ATPase activity17050692.IMPFunction
GO:0055085transmembrane transport21873635.IBAProcess
GO:0055085transmembrane transport-TASProcess
GO:0060326cell chemotaxis17050692.ISSProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:0099039sphingolipid translocation17050692.IMPProcess
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