EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22064657	Regulation of CXCL8/IL-8 expression by zonula occludens-1 in human breast cancer cells.	Mol Cancer Res	2012 Jan	Brysse A	doi: 10.1158/1541-7786.MCR-11-0180
25452107	MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5.	Cell Signal	2015 Jan	Miao YS	doi: 10.1016/j.cellsig.2014.10.008
16140936	Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells.	Cancer Res	2005 Sep 1	Polette M	-
26293574	Unraveling the Role of Huntingtin in Breast Cancer Metastasis.	J Natl Cancer Inst	2015 Aug 20	Thion MS	doi: 10.1093/jnci/djv208
19885549	Localization of cortactin is associated with colorectal cancer development.	Int J Oncol	2009 Dec	Hirakawa H	-
29384218	microRNA-130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO-1.	J Cell Biochem	2018 Jun	Chen X	doi: 10.1002/jcb.26739
24294375	Increased ZO-1 expression predicts valuable prognosis in non-small cell lung cancer.	Int J Clin Exp Pathol	2013 Nov 15	Ni S	-
30061227	Tight Junction Protein 1 Dysfunction Contributes to Cell Motility in Bladder Cancer.	Anticancer Res	2018 Aug	Tsai KW	doi: 10.21873/anticanres.12765.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr15	29726450	Missense_Mutation	novel	G781C	0.13
BLCA	chr15	29766528	Silent	novel	K109K	0.24
BLCA	chr15	29726852	Missense_Mutation	NA	S747F	0.37
BLCA	chr15	29718406	Missense_Mutation	rs372074311	P1246S	0.62
BLCA	chr15	29718980	Silent	rs759944079	L1054L	0.23
BLCA	chr15	29726826	Nonsense_Mutation	novel	E756*	0.23
BLCA	chr15	29716726	Missense_Mutation	novel	D1363N	0.11
BLCA	chr15	29718597	Missense_Mutation	NA	G1182V	0.28
BLCA	chr15	29718817	Nonsense_Mutation	novel	Q1109*	0.24
BLCA	chr15	29772099	Nonsense_Mutation	NA	Q93*	0.3
BLCA	chr15	29716643	Silent	novel	Q1390Q	0.09
BLCA	chr15	29761752	Nonsense_Mutation	novel	E238*	0.12
BLCA	chr15	29701565	3'UTR	novel		0.37
BLCA	chr15	29766266	In_Frame_Del	novel	E197del	0.13
BRCA	chr15	29761282	Silent	novel	I289I	0.05
BRCA	chr15	29708816	Silent	rs200615605	P1531P	0.19
BRCA	chr15	29732812	Silent	NA	A580A	0.64
BRCA	chr15	29732630	Splice_Site	novel	X641_splice	0.27
BRCA	chr15	29727959	Missense_Mutation	novel	T693I	0.07
BRCA	chr15	29732475	Nonsense_Mutation	NA	E659*	0.44
BRCA	chr15	29726776	Splice_Site	novel	X765_splice	0.13
BRCA	chr15	29773287	Missense_Mutation	novel	T52K	0.07
BRCA	chr15	29710955	Silent	NA	E1416E	0.32
BRCA	chr15	29732811	Missense_Mutation	novel	E581Q	0.11
BRCA	chr15	29718940	Missense_Mutation	rs761548583	D1068N	0.22
BRCA	chr15	29716711	Missense_Mutation	novel	E1368Q	0.41
BRCA	chr15	29737267	Silent	novel	L468L	0.19
BRCA	chr15	29718872	Missense_Mutation	NA	Q1090H	0.35
BRCA	chr15	29820645	Intron	novel		0.08
BRCA	chr15	29705583	Missense_Mutation	novel	I1671M	0.1
BRCA	chr15	29718283	Missense_Mutation	novel	D1287Y	0.09
BRCA	chr15	29708905	Nonsense_Mutation	novel	*K1502Ffs4**	0.07
BRCA	chr15	29718524	In_Frame_Ins	novel	G1206_F1207insTKDI	0.07
BRCA	chr15	29718524	In_Frame_Ins	novel	G1206_F1207insI	0.08
BRCA	chr15	29718525	Missense_Mutation	novel	G1206E	0.08
BRCA	chr15	29718586	Missense_Mutation	NA	A1186T	0.36
BRCA	chr15	29761608	Missense_Mutation	NA	E285D	0.35
BRCA	chr15	29720597	Frame_Shift_Ins	novel	*D842Lfs18**	0.42
CESC	chr15	29820546	Intron	NA		0.5
CESC	chr15	29700212	3'UTR	novel		0.4
CESC	chr15	29701295	3'UTR	rs147285364		0.4
CESC	chr15	29726477	Missense_Mutation	novel	T772A	0.26
CESC	chr15	29737323	Missense_Mutation	novel	V450I	0.41
CESC	chr15	29742776	Missense_Mutation	NA	R339Q	0.29
CESC	chr15	29761193	Missense_Mutation	rs780286880	R319Q	0.37
CESC	chr15	29732805	Missense_Mutation	novel	L583I	0.11
CESC	chr15	29720488	Missense_Mutation	NA	S878F	0.16
CESC	chr15	29704167	Intron	rs761419687		0.13
CESC	chr15	29766528	Silent	novel	K109K	0.06
CESC	chr15	29705594	Missense_Mutation	novel	E1668Q	0.21
CESC	chr15	29766483	Silent	novel	V124V	0.13
CESC	chr15	29742675	Missense_Mutation	NA	E373Q	0.27
CESC	chr15	29716635	Missense_Mutation	novel	S1393L	0.39
COAD	chr15	29708798	Silent	NA	R1537R	0.22
COAD	chr15	29726437	Missense_Mutation	NA	A785V	0.17
COAD	chr15	29733170	Silent	novel	L554L	0.09
COAD	chr15	29726808	Missense_Mutation	novel	R762C	0.23
COAD	chr15	29719075	Missense_Mutation	novel	A1023T	0.29
COAD	chr15	29737323	Missense_Mutation	novel	V450I	0.41
COAD	chr15	29710829	Splice_Site	novel	X1458_splice	0.25
COAD	chr15	29762399	Missense_Mutation	NA	E210A	0.17
COAD	chr15	29719795	Silent	rs368537788	S995S	0.29
COAD	chr15	29773318	Nonsense_Mutation	NA	R42*	0.92
COAD	chr15	29726388	Silent	rs2229516	S801S	0.45
COAD	chr15	29720703	Silent	novel	D806D	0.48
COAD	chr15	29734342	Missense_Mutation	NA	A483V	0.43
COAD	chr15	29734374	Silent	rs769336192	N472N	0.17
COAD	chr15	29761670	Missense_Mutation	rs754428169	R265W	0.36
COAD	chr15	29704268	Silent	novel	P1702P	0.79
COAD	chr15	29734341	Silent	rs543455376	A483A	0.41
COAD	chr15	29733304	Missense_Mutation	rs776245658	R509H	0.31
COAD	chr15	29772090	Missense_Mutation	NA	R96W	0.27
COAD	chr15	29710868	Silent	rs774848779	A1445A	0.25
COAD	chr15	29719007	Silent	rs373853690	Y1045Y	0.21
COAD	chr15	29701581	3'UTR	novel		0.32
COAD	chr15	29704164	Intron	rs45460497		0.17
COAD	chr15	29766286	Missense_Mutation	novel	V190A	0.28
COAD	chr15	29701637	Silent	NA	L1735L	0.26
COAD	chr15	29773318	Nonsense_Mutation	NA	R42*	0.25
COAD	chr15	29701679	Missense_Mutation	rs200595796	K1721N	0.17
COAD	chr15	29718683	Silent	rs201782508	S1153S	0.05
COAD	chr15	29820578	Intron	novel		0.12
COAD	chr15	29761742	Missense_Mutation	NA	S241A	0.49
COAD	chr15	29761743	Missense_Mutation	NA	M240I	0.5
DLBC	chr15	29719075	Missense_Mutation	novel	A1023P	0.82
DLBC	chr15	29822045	5'UTR	novel		0.36
ESCA	chr15	29708626	Missense_Mutation	novel	I1595V	0.27
ESCA	chr15	29766335	Missense_Mutation	novel	R174W	0.56
ESCA	chr15	29773237	Missense_Mutation	novel	L69V	0.19
ESCA	chr15	29719898	Frame_Shift_Del	novel	*P961Qfs14**	0.3
GBM	chr15	29720385	Silent	novel	S912S	0.06
GBM	chr15	29726379	Splice_Region	novel	K804K	0.39
GBM	chr15	29727968	Missense_Mutation	rs201475376	R690H	0.33
GBM	chr15	29719987	Nonsense_Mutation	novel	Y931*	0.34
GBM	chr15	29708679	Missense_Mutation	rs61736881	S1577L	0.48
GBM	chr15	29737323	Missense_Mutation	novel	V450I	0.13
GBM	chr15	29710947	Missense_Mutation	rs200549140	Y1419C	0.11
GBM	chr15	29761197	Nonsense_Mutation	NA	Q318*	0.54
HNSC	chr15	29800656	Missense_Mutation	rs375824999	T25M	0.33
HNSC	chr15	29766372	Silent	novel	A161A	0.14
HNSC	chr15	29762408	Missense_Mutation	novel	F207S	0.14
HNSC	chr15	29719007	Silent	rs373853690	Y1045Y	0.3
HNSC	chr15	29716768	Missense_Mutation	novel	E1349K	0.17
HNSC	chr15	29732495	Missense_Mutation	novel	P652L	0.21
HNSC	chr15	29733160	Nonsense_Mutation	novel	W557*	0.16
HNSC	chr15	29716656	Missense_Mutation	novel	P1386L	0.21
HNSC	chr15	29710935	Missense_Mutation	novel	Q1423L	0.32
HNSC	chr15	29710915	Missense_Mutation	novel	P1430A	0.41
HNSC	chr15	29741335	Missense_Mutation	novel	L418F	0.45
HNSC	chr15	29720597	Missense_Mutation	novel	D842N	0.53
HNSC	chr15	29726463	Silent	novel	N776N	0.25
HNSC	chr15	29720386	Missense_Mutation	novel	S912F	0.34
KICH	chr15	29718676	Missense_Mutation	rs747859807	R1156W	0.22
KIRC	chr15	29734347	Silent	NA	E481E	0.06
KIRC	chr15	29772085	Missense_Mutation	NA	K97N	0.28
KIRC	chr15	29719944	Missense_Mutation	NA	N946Y	0.32
KIRP	chr15	29716616	Silent	NA	S1399S	0.12
KIRP	chr15	29773326	Missense_Mutation	NA	S39Y	0.17
KIRP	chr15	29726878	Silent	NA	T738T	0.24
LAML	chr15	29719045	Missense_Mutation	novel	K1033E	0.08
LAML	chr15	29718865	Missense_Mutation	novel	Y1093D	0.24
LAML	chr15	29708629	Missense_Mutation	NA	S1594P	0.45
LGG	chr15	29732694	Missense_Mutation	novel	D620N	0.32
LGG	chr15	29761719	Missense_Mutation	novel	L248F	0.38
LGG	chr15	29710868	Silent	rs774848779	A1445A	0.18
LGG	chr15	29766427	Missense_Mutation	rs377122303	R143Q	0.27
LGG	chr15	29708800	Nonsense_Mutation	NA	R1537*	0.29
LGG	chr15	29710950	Missense_Mutation	rs769496614	R1418H	0.38
LGG	chr15	29732767	Silent	rs756065514	G595G	0.34
LIHC	chr15	29718949	Missense_Mutation	NA	S1065G	0.29
LIHC	chr15	29708792	Frame_Shift_Del	novel	F1539*	0.38
LIHC	chr15	29718385	Nonsense_Mutation	NA	E1253*	0.31
LIHC	chr15	29718463	Missense_Mutation	novel	I1227V	0.45
LIHC	chr15	29701574	3'UTR	novel		0.36
LIHC	chr15	29705621	Missense_Mutation	novel	P1659S	0.17
LIHC	chr15	29719904	Missense_Mutation	NA	P959L	0.45
LUAD	chr15	29761711	Missense_Mutation	novel	R251M	0.15
LUAD	chr15	29718098	Missense_Mutation	NA	K1299N	0.8
LUAD	chr15	29761171	Silent	rs771873571	S326S	0.22
LUAD	chr15	29732740	Silent	NA	F604F	0.37
LUAD	chr15	29728018	Missense_Mutation	NA	K673N	0.34
LUAD	chr15	29719877	Missense_Mutation	novel	S968L	0.15
LUAD	chr15	29762388	Missense_Mutation	novel	D214Y	0.11
LUAD	chr15	29708743	Nonsense_Mutation	novel	E1556*	0.13
LUAD	chr15	29718497	Missense_Mutation	NA	E1215D	0.15
LUAD	chr15	29719799	Missense_Mutation	rs751977843	S994L	0.1
LUAD	chr15	29732759	Missense_Mutation	NA	R598L	0.07
LUAD	chr15	29716617	Missense_Mutation	novel	S1399F	0.07
LUAD	chr15	29741345	Silent	novel	E414E	0.33
LUAD	chr15	29734356	Silent	rs367703610	I478I	0.19
LUAD	chr15	29732685	Missense_Mutation	NA	A623S	0.68
LUAD	chr15	29766360	Missense_Mutation	novel	R165S	0.25
LUAD	chr15	29716746	Missense_Mutation	rs762084848	R1356Q	0.64
LUSC	chr15	29719947	Missense_Mutation	novel	V945F	0.34
LUSC	chr15	29761214	Missense_Mutation	rs748619818	R312Q	0.12
LUSC	chr15	29742770	Missense_Mutation	novel	R341T	0.16
LUSC	chr15	29716684	Missense_Mutation	novel	A1377T	0.31
LUSC	chr15	29733201	Silent	novel	F543F	0.31
LUSC	chr15	29719977	Missense_Mutation	novel	E935Q	0.13
LUSC	chr15	29726866	Missense_Mutation	novel	R742S	0.13
LUSC	chr15	29710917	Frame_Shift_Del	novel	*P1429Lfs41**	0.85
LUSC	chr15	29718723	Missense_Mutation	novel	Y1140F	0.4
LUSC	chr15	29733295	Missense_Mutation	novel	E512A	0.23
LUSC	chr15	29705702	Missense_Mutation	NA	V1632L	0.11
LUSC	chr15	29708985	Missense_Mutation	novel	P1475L	0.28
LUSC	chr15	29732682	Nonsense_Mutation	NA	Q624*	0.79
LUSC	chr15	29708733	Frame_Shift_Del	novel	*H1559Lfs17**	0.32
LUSC	chr15	29716709	Silent	novel	E1368E	0.23
LUSC	chr15	29762384	Missense_Mutation	novel	S215I	0.46
LUSC	chr15	29766518	Nonsense_Mutation	NA	Q113*	0.32
LUSC	chr15	29737347	Missense_Mutation	novel	D442H	0.3
LUSC	chr15	29718671	Missense_Mutation	novel	H1157Q	0.15
LUSC	chr15	29737298	Missense_Mutation	NA	K458M	0.46
LUSC	chr15	29708573	Missense_Mutation	novel	K1612N	0.51
LUSC	chr15	29800663	Missense_Mutation	NA	T23A	0.24
LUSC	chr15	29701636	Missense_Mutation	rs369915729	V1736F	0.22
LUSC	chr15	29732439	Missense_Mutation	NA	I671L	0.11
LUSC	chr15	29719808	Missense_Mutation	novel	P991L	0.15
LUSC	chr15	29708729	Missense_Mutation	NA	K1560N	0.82
MESO	chr15	29772155	Missense_Mutation	rs745465485	R74Q	0.73
OV	chr15	29719910	Missense_Mutation	NA	E957V	0.58
OV	chr15	29718592	Frame_Shift_Del	NA	*H1178Qfs10**	0.4
OV	chr15	29710933	Missense_Mutation	novel	A1424T	0.05
OV	chr15	29742743	Missense_Mutation	novel	G350E	0.07
OV	chr15	29733126	Silent	NA	E568E	0.28
OV	chr15	29701672	Missense_Mutation	NA	Q1724E	0.21
OV	chr15	29732661	Frame_Shift_Ins	novel	*P631Afs15**	0.07
PAAD	chr15	29728008	Nonsense_Mutation	novel	R677*	0.1
PAAD	chr15	29710934	Missense_Mutation	novel	Q1423H	0.18
PAAD	chr15	29718727	Missense_Mutation	rs141258029	S1139P	0.17
PAAD	chr15	29718815	Missense_Mutation	novel	Q1109H	0.16
PAAD	chr15	29719804	Silent	novel	S992S	0.16
PAAD	chr15	29773358	Splice_Site	novel	X29_splice	0.14
PRAD	chr15	29732802	Missense_Mutation	NA	A584S	0.48
PRAD	chr15	29761662	Silent	rs764484998	T267T	0.12
READ	chr15	29719970	Missense_Mutation	NA	N937S	0.26
READ	chr15	29718769	Missense_Mutation	NA	E1125Q	0.17
READ	chr15	29705738	Missense_Mutation	novel	A1620P	0.17
READ	chr15	29718930	Missense_Mutation	NA	S1071F	0.27
READ	chr15	29708715	Nonsense_Mutation	NA	S1565*	0.44
READ	chr15	29732634	Nonsense_Mutation	NA	E640*	0.36
READ	chr15	29766387	Silent	rs199932396	P156P	0.43
READ	chr15	29705638	Missense_Mutation	novel	G1653D	0.3
READ	chr15	29732480	Missense_Mutation	NA	A657V	0.38
SARC	chr15	29704280	Silent	rs575536449	V1698V	0.2
SARC	chr15	29741423	Silent	novel	V388V	0.1
SARC	chr15	29704290	Missense_Mutation	novel	S1695T	0.14
SARC	chr15	29766429	Silent	novel	G142G	0.46
SARC	chr15	29716669	Missense_Mutation	rs541526165	E1382K	0.47
SARC	chr15	29720617	Missense_Mutation	rs752322243	T835M	0.41
SKCM	chr15	29701612	Missense_Mutation	NA	L1744F	0.24
SKCM	chr15	29705622	Silent	rs755521613	I1658I	0.22
SKCM	chr15	29734320	Silent	novel	L490L	0.28
SKCM	chr15	29732513	Missense_Mutation	NA	P646L	0.19
SKCM	chr15	29732730	Missense_Mutation	rs751151456	R608C	0.21
SKCM	chr15	29734356	Silent	rs367703610	I478I	0.27
SKCM	chr15	29766371	Missense_Mutation	NA	S162R	0.15
SKCM	chr15	29742654	Missense_Mutation	NA	P380S	0.22
SKCM	chr15	29766334	Missense_Mutation	rs781078737	R174Q	0.22
SKCM	chr15	29734338	Silent	novel	V484V	0.28
SKCM	chr15	29716825	Nonsense_Mutation	NA	Q1330*	0.57
SKCM	chr15	29718066	Missense_Mutation	rs372973125	P1310L	0.38
SKCM	chr15	29733108	Silent	NA	I574I	0.3
SKCM	chr15	29718828	Missense_Mutation	NA	P1105L	0.43
SKCM	chr15	29708813	Nonsense_Mutation	novel	Y1532*	0.28
SKCM	chr15	29741417	Silent	novel	A390A	0.31
SKCM	chr15	29716835	Silent	rs373398760	I1326I	0.23
SKCM	chr15	29716752	Missense_Mutation	NA	Y1354C	0.47
SKCM	chr15	29733163	Missense_Mutation	NA	S556F	0.37
SKCM	chr15	29709006	Missense_Mutation	NA	S1468F	0.65
SKCM	chr15	29718711	Missense_Mutation	novel	P1144L	0.49
SKCM	chr15	29742751	Silent	novel	S347S	0.27
SKCM	chr15	29761176	Missense_Mutation	NA	H325Y	0.28
SKCM	chr15	29734331	Silent	novel	L487L	0.28
SKCM	chr15	29734332	Missense_Mutation	novel	F486L	0.29
SKCM	chr15	29718927	Missense_Mutation	rs180850389	R1072Q	0.19
STAD	chr15	29718362	Missense_Mutation	novel	K1260N	0.13
STAD	chr15	29718363	Missense_Mutation	novel	K1260T	0.13
STAD	chr15	29766446	Missense_Mutation	rs202151545	H137Y	0.23
STAD	chr15	29726939	Missense_Mutation	rs774071639	Y718C	0.16
STAD	chr15	29718303	Missense_Mutation	novel	E1280A	0.12
STAD	chr15	29701508	3'UTR	novel		0.46
STAD	chr15	29719050	Missense_Mutation	NA	P1031Q	0.3
STAD	chr15	29708941	Nonsense_Mutation	rs775677800	R1490*	0.29
STAD	chr15	29718502	Missense_Mutation	NA	F1214V	0.46
STAD	chr15	29701613	Silent	NA	V1743V	0.1
STAD	chr15	29716746	Missense_Mutation	rs762084848	R1356Q	0.24
STAD	chr15	29742671	Missense_Mutation	NA	R374I	0.31
STAD	chr15	29716687	Missense_Mutation	novel	A1376T	0.33
STAD	chr15	29718567	Missense_Mutation	novel	F1192S	0.26
STAD	chr15	29705662	Frame_Shift_Del	novel	*G1645Afs3**	0.1
STAD	chr15	29732529	Splice_Site	NA	X641_splice	0.27
STAD	chr15	29718511	Missense_Mutation	novel	A1211S	0.23
STAD	chr15	29701508	3'UTR	novel		0.5
STAD	chr15	29726957	Missense_Mutation	NA	A712E	0.18
STAD	chr15	29800647	Missense_Mutation	NA	R28M	0.19
STAD	chr15	29718907	Nonsense_Mutation	NA	R1079*	0.29
STAD	chr15	29773265	Silent	rs774428839	V59V	0.29
STAD	chr15	29726437	Missense_Mutation	NA	A785V	0.3
STAD	chr15	29737323	Missense_Mutation	novel	V450I	0.14
STAD	chr15	29737330	Silent	NA	V447V	0.15
STAD	chr15	29732500	Frame_Shift_Del	NA	*F650Lfs4**	0.19
STAD	chr15	29705696	Missense_Mutation	NA	A1634T	0.27
STAD	chr15	29718638	Silent	novel	H1168H	0.41
STAD	chr15	29719115	Silent	rs45562135	P1009P	0.27
STAD	chr15	29726930	Missense_Mutation	NA	W721L	0.49
STAD	chr15	29773317	Missense_Mutation	NA	R42Q	0.38
STAD	chr15	29718516	Missense_Mutation	NA	S1209F	0.37
STAD	chr15	29710831	Missense_Mutation	NA	G1458C	0.11
STAD	chr15	29705590	Missense_Mutation	rs201192620	Q1669R	0.29
STAD	chr15	29773300	Frame_Shift_Ins	novel	*Q48Sfs19**	0.18
STAD	chr15	29761162	Silent	rs770559228	S329S	0.09
THCA	chr15	29761274	Frame_Shift_Ins	novel	*I292Sfs67**	0.06
THCA	chr15	29716619	Nonsense_Mutation	novel	Y1398*	0.08
THCA	chr15	29720426	Missense_Mutation	NA	S899A	0.27
UCEC	chr15	29742674	Missense_Mutation	novel	E373G	0.4
UCEC	chr15	29720395	Missense_Mutation	NA	R909I	0.37
UCEC	chr15	29727942	Missense_Mutation	NA	D699Y	0.25
UCEC	chr15	29700272	3'UTR	rs538206506		0.13
UCEC	chr15	29701238	3'UTR	novel		0.3
UCEC	chr15	29708833	Nonsense_Mutation	novel	R1526*	0.1
UCEC	chr15	29718670	Missense_Mutation	NA	E1158K	0.04
UCEC	chr15	29718781	Missense_Mutation	rs374354747	E1121K	0.32
UCEC	chr15	29762355	Nonsense_Mutation	NA	E225*	0.32
UCEC	chr15	29720537	Missense_Mutation	rs370774822	L862F	0.31
UCEC	chr15	29719881	Missense_Mutation	novel	Y967H	0.25
UCEC	chr15	29761662	Silent	rs764484998	T267T	0.46
UCEC	chr15	29762345	Missense_Mutation	NA	V228A	0.58
UCEC	chr15	29734373	Missense_Mutation	rs371036893	V473I	0.29
UCEC	chr15	29701060	3'UTR	novel		0.25
UCEC	chr15	29718335	Missense_Mutation	novel	K1269N	0.26
UCEC	chr15	29719104	Missense_Mutation	novel	M1013T	0.19
UCEC	chr15	29800655	Silent	rs754587324	T25T	0.08
UCEC	chr15	29708618	Silent	novel	A1597A	0.04
UCEC	chr15	29733174	Silent	novel	G552G	0.06
UCEC	chr15	29700454	3'UTR	novel		0.6
UCEC	chr15	29766448	Missense_Mutation	novel	I136T	0.44
UCEC	chr15	29700670	3'UTR	novel		0.11
UCEC	chr15	29716722	Missense_Mutation	rs770537746	R1364Q	0.44
UCEC	chr15	29773303	Missense_Mutation	novel	F47V	0.38
UCEC	chr15	29700363	3'UTR	novel		0.36
UCEC	chr15	29705704	Missense_Mutation	novel	T1631I	0.44
UCEC	chr15	29720007	Missense_Mutation	novel	A925S	0.47
UCEC	chr15	29720456	Missense_Mutation	novel	H889Y	0.38
UCEC	chr15	29726948	Missense_Mutation	rs200221423	R715H	0.28
UCEC	chr15	29700670	3'UTR	novel		0.14
UCEC	chr15	29701250	3'UTR	novel		0.16
UCEC	chr15	29708937	Missense_Mutation	NA	E1491V	0.14
UCEC	chr15	29718099	Missense_Mutation	NA	K1299T	0.29
UCEC	chr15	29718523	Frame_Shift_Ins	novel	*F1207Hfs5**	0.05
UCEC	chr15	29718263	Splice_Region	novel		0.37
UCEC	chr15	29734303	Missense_Mutation	NA	V496A	0.43
UCEC	chr15	29718524	In_Frame_Ins	novel	G1206_F1207insTKDI	0.14
UCEC	chr15	29719795	Silent	rs368537788	S995S	0.14
UCEC	chr15	29742768	Missense_Mutation	NA	D342N	0.22
UCEC	chr15	29718776	Silent	novel	E1122E	0.2
UCEC	chr15	29732648	Missense_Mutation	novel	R635I	0.19
UCEC	chr15	29800690	Nonsense_Mutation	novel	E14*	0.19
UCEC	chr15	29705583	Silent	rs764299023	I1671I	0.45
UCEC	chr15	29720380	Missense_Mutation	NA	G914E	0.45
UCEC	chr15	29719132	Nonsense_Mutation	novel	*R1004Sfs2**	0.05
UCEC	chr15	29701639	Missense_Mutation	novel	L1735I	0.1
UCEC	chr15	29733148	Missense_Mutation	rs369890947	R561Q	0.15
UCEC	chr15	29716746	Missense_Mutation	rs762084848	R1356Q	0.42
UCEC	chr15	29719828	Silent	novel	I984I	0.07
UCEC	chr15	29734307	Nonsense_Mutation	novel	E495*	0.43
UCEC	chr15	29718415	Frame_Shift_Ins	novel	*P1243Tfs27**	0.33
UCEC	chr15	29719850	Missense_Mutation	novel	P977L	0.21
UCEC	chr15	29737294	Frame_Shift_Del	novel	*G460Afs2**	0.25
UCEC	chr15	29700205	3'UTR	novel		0.21
UCEC	chr15	29701060	3'UTR	novel		0.4
UCEC	chr15	29718350	Silent	novel	V1264V	0.32
UCEC	chr15	29719795	Silent	rs368537788	S995S	0.41
UCEC	chr15	29733304	Missense_Mutation	rs776245658	R509H	0.43
UCEC	chr15	29741425	Missense_Mutation	novel	V388L	0.16
UCEC	chr15	29704164	Intron	rs45460497		0.45
UCEC	chr15	29726808	Missense_Mutation	novel	R762C	0.25
UCEC	chr15	29716793	Missense_Mutation	novel	I1340M	0.45
UCEC	chr15	29732766	Missense_Mutation	novel	G596R	0.43
UCEC	chr15	29705532	Missense_Mutation	novel	E1688D	0.33
UCEC	chr15	29719007	Silent	rs373853690	Y1045Y	0.42
UCEC	chr15	29800655	Silent	rs754587324	T25T	0.45
UCEC	chr15	29719981	Silent	rs369526482	S933S	0.43
UCEC	chr15	29734331	Frame_Shift_Ins	novel	*L487Cfs15**	0.04
UCEC	chr15	29700454	3'UTR	novel		0.83
UCEC	chr15	29701483	3'UTR	novel		0.53
UCEC	chr15	29720416	Missense_Mutation	rs754602712	A902V	0.33
UCEC	chr15	29727968	Missense_Mutation	rs201475376	R690H	0.34
UCEC	chr15	29762415	Frame_Shift_Del	novel	*H205Ifs26**	0.74
UCEC	chr15	29704167	Intron	rs761419687		0.37
UCEC	chr15	29700454	3'UTR	novel		0.41
UCEC	chr15	29700842	3'UTR	novel		0.23
UCEC	chr15	29701006	3'UTR	novel		0.29
UCEC	chr15	29716819	Frame_Shift_Ins	novel	*P1332Tfs7**	0.17
UCEC	chr15	29732472	Missense_Mutation	novel	K660E	0.3
UCEC	chr15	29773283	Silent	novel	S53S	0.38
UCEC	chr15	29701029	3'UTR	novel		0.37
UCEC	chr15	29708941	Nonsense_Mutation	rs775677800	R1490*	0.24
UCEC	chr15	29726399	Missense_Mutation	novel	V798L	0.19
UCEC	chr15	29719795	Silent	rs368537788	S995S	0.42
UCEC	chr15	29720665	Missense_Mutation	rs757146968	R819H	0.55
UCEC	chr15	29766347	Missense_Mutation	rs749565170	R170W	0.53
UCEC	chr15	29700454	3'UTR	novel		0.41
UCEC	chr15	29737270	Silent	novel	I467I	0.17
UCEC	chr15	29700454	3'UTR	novel		0.43
UCEC	chr15	29708679	Missense_Mutation	rs61736881	S1577L	0.34
UCEC	chr15	29719986	Missense_Mutation	novel	L932I	0.37
UCEC	chr15	29726849	Missense_Mutation	rs538345537	R748Q	0.4
UCEC	chr15	29800686	Missense_Mutation	novel	E15G	0.45
UCEC	chr15	29710881	Missense_Mutation	novel	P1441H	0.18
UCEC	chr15	29726396	Missense_Mutation	NA	W799R	0.27
UCEC	chr15	29705603	Missense_Mutation	rs200636289	E1665K	0.36
UCEC	chr15	29708805	Missense_Mutation	novel	S1535Y	0.41
UCEC	chr15	29718526	Nonsense_Mutation	novel	G1206*	0.49
UCEC	chr15	29700454	3'UTR	novel		0.52
UCEC	chr15	29733148	Missense_Mutation	rs369890947	R561Q	0.07
UCEC	chr15	29733136	Frame_Shift_Del	novel	*N565Ifs5**	0.46
UCEC	chr15	29700306	3'UTR	novel		0.56
UCEC	chr15	29700454	3'UTR	novel		0.59
UCEC	chr15	29718423	Missense_Mutation	novel	N1240S	0.18
UCEC	chr15	29766334	Missense_Mutation	rs781078737	R174Q	0.38
UCEC	chr15	29726955	Missense_Mutation	novel	V713L	0.25
UCEC	chr15	29733304	Missense_Mutation	rs776245658	R509H	0.1
UCEC	chr15	29708629	Missense_Mutation	NA	S1594P	0.37
UCEC	chr15	29718524	In_Frame_Ins	novel	G1206_F1207insTKDI	0.04
UCEC	chr15	29773318	Nonsense_Mutation	NA	R42*	0.22
UCEC	chr15	29761703	Missense_Mutation	NA	G254C	0.36
UCEC	chr15	29718956	Missense_Mutation	novel	E1062D	0.35
UCEC	chr15	29718524	In_Frame_Ins	novel	G1206_F1207insTKDI	0.14
UCEC	chr15	29733308	Missense_Mutation	rs764984835	R508C	0.39
UCEC	chr15	29742716	Missense_Mutation	rs372663991	A359V	0.42
UCEC	chr15	29742684	Missense_Mutation	NA	V370F	0.26
UCEC	chr15	29720626	Missense_Mutation	novel	M832T	0.34
UCEC	chr15	29708578	Missense_Mutation	novel	P1611S	0.23
UCEC	chr15	29708787	Missense_Mutation	novel	R1541H	0.21
UCEC	chr15	29718060	Missense_Mutation	novel	S1312Y	0.21
UCEC	chr15	29718318	Missense_Mutation	novel	R1275K	0.21
UCEC	chr15	29718781	Missense_Mutation	rs374354747	E1121K	0.24
UCEC	chr15	29719908	Missense_Mutation	NA	E958K	0.42
UCEC	chr15	29726826	Missense_Mutation	rs754072191	E756K	0.23
UCEC	chr15	29728002	Missense_Mutation	novel	A679T	0.12
UCEC	chr15	29732708	Missense_Mutation	novel	R615Q	0.26
UCEC	chr15	29734373	Missense_Mutation	rs371036893	V473I	0.16
UCEC	chr15	29742759	Silent	novel	R345R	0.26
UCEC	chr15	29761763	Missense_Mutation	novel	G234S	0.41
UCEC	chr15	29716746	Missense_Mutation	rs762084848	R1356Q	0.31
UCEC	chr15	29708802	Missense_Mutation	novel	A1536V	0.25
UCEC	chr15	29718489	Missense_Mutation	NA	H1218R	0.27
UCEC	chr15	29700384	3'UTR	novel		0.35
UCEC	chr15	29710962	Missense_Mutation	novel	F1414C	0.46
UCEC	chr15	29719862	Missense_Mutation	rs768426404	S973Y	0.41
UCEC	chr15	29734292	Missense_Mutation	novel	A500P	0.44
UCEC	chr15	29772139	Silent	rs756820699	N79N	0.28
UCEC	chr15	29820551	Intron	novel		0.36
UCS	chr15	29742758	Missense_Mutation	novel	R345I	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2111	0.079424
BLCA	DEL	0.3186	0.00034787
BRCA	DEL	0.2954	9.0465e-17
COAD	DEL	0.357	1.0065e-06
ESCA	DEL	0.2065	0.035837
HNSC	DEL	0.1571	0.11567
KICH	AMP	0.2727	0.21756
KIRP	DEL	0.1111	0.2062
LUAD	DEL	0.3857	6.8561e-07
LUSC	DEL	0.2555	5.9764e-05
PAAD	DEL	0.1196	0.13216
READ	DEL	0.4303	0.025797
SARC	DEL	0.1907	0.18974
SKCM	DEL	0.1826	1.0926e-08
STAD	DEL	0.1814	3.7853e-05
UCEC	DEL	0.2115	7.1012e-08
UCS	DEL	0.6607	4.9548e-10

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0099	Kaplan-Meier Survival Analysis
KIRC	0.00014	Kaplan-Meier Survival Analysis
STAD	0.006	Kaplan-Meier Survival Analysis
ACC	0.0019	Kaplan-Meier Survival Analysis
SKCM	0.041	Kaplan-Meier Survival Analysis
BRCA	0.029	Kaplan-Meier Survival Analysis
PAAD	0.0018	Kaplan-Meier Survival Analysis
LAML	0.00045	Kaplan-Meier Survival Analysis
CHOL	0.018	Kaplan-Meier Survival Analysis
LUAD	0.03	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000104067 (Gene tree)
Gene ID: 7082
Gene Symbol: TJP1
Alias: ZO-1|MGC133289|DKFZp686M05161
Full Name: tight junction protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 269,499 bases
Position: chr15:29,699,367-29,968,865
Accession: 11827
RBP type: non-canonical RBP
Summary: This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18562690	JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function.	Mol Biol Cell	2008 Sep	Chen J	doi: 10.1091/mbc.E08-02-0175
26884465	H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR.	Mol Cell Biol	2016 Apr 15	Zou T	doi: 10.1128/MCB.01030-15
11518717	IGF-I receptor-induced cell-cell adhesion of MCF-7 breast cancer cells requires the expression of junction protein ZO-1.	J Biol Chem	2001 Oct 26	Mauro L	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000485381	TJP1-207	803	-	-	- (aa)	-	-
ENST00000356107	TJP1-202	6747	XM_017022521	ENSP00000348416	1768 (aa)	XP_016878010	G3V1L9
ENST00000614355	TJP1-212	6977	XM_005254619	ENSP00000483470	1676 (aa)	XP_005254676	A0A087X0K9
ENST00000462916	TJP1-205	698	-	-	- (aa)	-	-
ENST00000561307	TJP1-211	598	-	-	- (aa)	-	-
ENST00000495972	TJP1-208	2890	-	ENSP00000452729	383 (aa)	-	H0YKB1
ENST00000545208	TJP1-209	5007	-	ENSP00000441202	1668 (aa)	-	Q07157
ENST00000558447	TJP1-210	720	-	ENSP00000453334	231 (aa)	-	H0YLT6
ENST00000400007	TJP1-203	1032	-	ENSP00000382887	227 (aa)	-	H0Y3R8
ENST00000473741	TJP1-206	270	-	-	- (aa)	-	-
ENST00000400011	TJP1-204	6764	XM_017022525	ENSP00000382890	1692 (aa)	XP_016878014	G5E9E7
ENST00000346128	TJP1-201	7950	XM_011521972	ENSP00000281537	1748 (aa)	XP_011520274	Q07157

Gene Model

Click here to download ENSG00000104067's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04520	Adherens junction	KEGG
hsa04530	Tight junction	KEGG
hsa04540	Gap junction	KEGG
hsa05110	Vibrio cholerae infection	KEGG
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	KEGG
hsa05132	Salmonella infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000104067	monocyte chemoattractant protein 1 (66-77)	5.7420000E-005	-
ENSG00000104067	Interleukin-6	3.9700000E-005	-
ENSG00000104067	Corneal Topography	3E-11	23291589
ENSG00000104067	Risperidone	2E-7	23241943

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000104067	rs785422	15	29881682	T	Central corneal thickness	29760442	[2.81-5.01] unit decrease	3.91	EFO_0005213
ENSG00000104067	rs711355	15	29901265	T	Response to antipsychotic treatment	23241943			GO_0097336
ENSG00000104067	rs785422	15	29881682	T	Corneal structure	23291589	[0.1-0.18] unit decrease	0.14	EFO_0004345
ENSG00000104067	rs74710884	15	29793820	?	Heel bone mineral density	30048462	[0.017-0.034] unit increase	0.0255473	EFO_0009270
ENSG00000104067	rs78026071	15	29813456	?	Gamma glutamyl transferase levels in excessive alcohol consumption	30589442	[0.15-0.37] unit increase	0.26	EFO_0004532\|EFO_0007878
ENSG00000104067	rs74710884	15	29793820	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104067's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000104067	TJP1	100	92.064	ENSMUSG00000030516	Tjp1	100	98.246	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002102	podosome	-	IEA	Component
GO:0005515	protein binding	9707407.11042084.11734628.12154091.16944923.17015620.17724469.18823282.19332538.20164257.20850437.21402783.22262837.23885123.28661558.29366904.	IPI	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005737	cytoplasm	11734628.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005913	cell-cell adherens junction	8486731.	TAS	Component
GO:0005921	gap junction	-	ISS	Component
GO:0005923	bicellular tight junction	11734628.14757759.18823282.22006950.	IDA	Component
GO:0007043	cell-cell junction assembly	8486731.	TAS	Process
GO:0016323	basolateral plasma membrane	16427635.	IDA	Component
GO:0030054	cell junction	28169360.	IDA	Component
GO:0030054	cell junction	-	TAS	Component
GO:0035329	hippo signaling	-	TAS	Process
GO:0042995	cell projection	-	IEA	Component
GO:0043296	apical junction complex	16427635.	IDA	Component
GO:0045177	apical part of cell	22006950.	IDA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0090557	establishment of endothelial intestinal barrier	23885123.	IMP	Process
GO:1901350	cell-cell signaling involved in cell-cell junction organization	8395056.	NAS	Process
GO:2000810	regulation of bicellular tight junction assembly	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.