EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19177006	RNA-binding motif protein 35A is a novel tumor suppressor for colorectal cancer.	Cell Cycle	2009 Feb 1	Leontieva OV	-
27045022	Altered Expression and Splicing of ESRP1 in Malignant Melanoma Correlates with Epithelial-Mesenchymal Status and Tumor-Associated Immune Cytolytic Activity.	Cancer Immunol Res	2016 Jun	Yao J	doi: 10.1158/2326-6066.CIR-15-0255
27650542	Epithelial splicing regulatory protein 1 and 2 paralogues correlate with splice signatures and favorable outcome in human colorectal cancer.	Oncotarget	2016 Nov 8	Deloria AJ	doi: 10.18632/oncotarget.12070.
28975893	The ESRP1-GPR137 axis contributes to intestinal pathogenesis.	Elife	2017 Oct 4	Mager LF	doi: 10.7554/eLife.28366.
28052020	The RNA-binding protein ESRP1 promotes human colorectal cancer progression.	Oncotarget	2017 Feb 7	Fagoonee S	doi: 10.18632/oncotarget.14318.
25143390	Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms.	J Biol Chem	2014 Oct 3	Ishii H	doi: 10.1074/jbc.M114.589432
27401076	Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression.	Adv Exp Med Biol	2017	Hayakawa A	doi: 10.1007/5584_2016_50.
27500490	ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.	J Clin Invest	2016 Sep 1	Larsen JE	doi: 10.1172/JCI76725
27911856	Splicing factor ratio as an index of epithelial-mesenchymal transition and tumor aggressiveness in breast cancer.	Oncotarget	2017 Jan 10	Fici P	doi: 10.18632/oncotarget.13682.
29130517	Mesenchymal splice isoform of CD44 (CD44s) promotes EMT/invasion and imparts stem-like properties to ovarian cancer cells.	J Cell Biochem	2018 Apr	Bhattacharya R	doi: 10.1002/jcb.26504

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr8	94646191	Missense_Mutation	NA	F133L	0.05
BLCA	chr8	94668220	Silent	novel	L401L	0.35
BLCA	chr8	94674398	Missense_Mutation	novel	D515N	0.16
BLCA	chr8	94641436	Silent	NA	L40L	0.29
BLCA	chr8	94678211	Missense_Mutation	novel	P554S	0.44
BLCA	chr8	94646279	Missense_Mutation	novel	E163K	0.2
BLCA	chr8	94692688	Missense_Mutation	novel	S611L	0.16
BLCA	chr8	94671562	Missense_Mutation	novel	R448H	0.1
BLCA	chr8	94641436	Silent	NA	L40L	0.53
BLCA	chr8	94678288	Silent	novel	L579L	0.15
BLCA	chr8	94643315	Missense_Mutation	NA	V92M	0.04
BLCA	chr8	94668169	Missense_Mutation	NA	Q384H	0.48
BRCA	chr8	94641971	Missense_Mutation	NA	E50K	0.44
BRCA	chr8	94678360	Silent	NA	A603A	0.17
BRCA	chr8	94674334	Missense_Mutation	novel	I493M	0.21
BRCA	chr8	94706187	3'UTR	novel		0.16
BRCA	chr8	94646263	Silent	rs376259698	D157D	0.18
BRCA	chr8	94643385	Missense_Mutation	novel	R115M	0.05
BRCA	chr8	94674351	Missense_Mutation	novel	D499G	0.08
BRCA	chr8	94664727	Silent	rs367614022	T225T	0.19
BRCA	chr8	94674506	Missense_Mutation	novel	C551R	0.05
BRCA	chr8	94705947	3'UTR	novel		0.07
BRCA	chr8	94646243	Missense_Mutation	novel	P151S	0.06
BRCA	chr8	94642053	Missense_Mutation	NA	S77W	0.38
BRCA	chr8	94706067	3'UTR	novel		0.33
CESC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.3
CESC	chr8	94646216	Nonsense_Mutation	NA	E142*	0.46
CESC	chr8	94665178	Missense_Mutation	NA	F305V	0.1
CESC	chr8	94674318	Missense_Mutation	NA	S488L	0.19
CESC	chr8	94668145	Silent	novel	L376L	0.26
CESC	chr8	94678328	Missense_Mutation	novel	A593T	0.12
CESC	chr8	94706101	3'UTR	novel		0.32
CESC	chr8	94671510	Missense_Mutation	novel	P431S	0.25
CESC	chr8	94662325	Missense_Mutation	NA	E182Q	0.32
COAD	chr8	94662276	Silent	NA	L165L	0.38
COAD	chr8	94674382	Frame_Shift_Ins	NA	*N512Kfs8**	0.48
COAD	chr8	94678259	Missense_Mutation	NA	A570T	0.18
COAD	chr8	94671539	Silent	novel	P440P	0.06
COAD	chr8	94696855	Missense_Mutation	NA	A659T	0.62
COAD	chr8	94641287	5'UTR	rs765041345		0.56
COAD	chr8	94641288	5'UTR	rs757019926		0.39
COAD	chr8	94692731	Silent	rs369829287	S625S	0.1
COAD	chr8	94674307	Splice_Site	NA	X485_splice	0.41
COAD	chr8	94665004	Missense_Mutation	NA	H278R	0.11
COAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.37
COAD	chr8	94671570	Missense_Mutation	NA	G451S	0.32
COAD	chr8	94671454	Missense_Mutation	NA	V412A	0.11
COAD	chr8	94641289	5'UTR	rs748556062		0.22
COAD	chr8	94674383	Frame_Shift_Del	NA	*N512Hfs7**	0.53
COAD	chr8	94641289	5'UTR	rs748556062		0.27
COAD	chr8	94665039	Missense_Mutation	NA	M290L	0.43
COAD	chr8	94668174	Missense_Mutation	NA	A386V	0.06
COAD	chr8	94696861	Missense_Mutation	rs775408778	E661K	0.31
COAD	chr8	94674471	Missense_Mutation	rs757908275	R539Q	0.39
COAD	chr8	94668009	Frame_Shift_Del	NA	*L333Sfs55**	0.35
COAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.35
COAD	chr8	94674383	Frame_Shift_Del	NA	*N512Hfs7**	0.12
DLBC	chr8	94664741	Missense_Mutation	NA	R230Q	0.4
ESCA	chr8	94678316	Missense_Mutation	NA	A589T	0.55
ESCA	chr8	94692754	Missense_Mutation	novel	T633R	0.14
ESCA	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.22
ESCA	chr8	94706480	3'UTR	novel		0.5
ESCA	chr8	94641279	5'UTR	novel		0.05
GBM	chr8	94671624	Missense_Mutation	rs542614931	A469T	0.24
GBM	chr8	94665048	Missense_Mutation	novel	R293W	0.2
GBM	chr8	94678260	Missense_Mutation	novel	A570D	0.2
HNSC	chr8	94641360	Silent	rs369835294	I14I	0.09
HNSC	chr8	94668239	Missense_Mutation	novel	E408K	0.14
HNSC	chr8	94646221	Silent	rs746386987	F143F	0.21
HNSC	chr8	94696864	Missense_Mutation	novel	D662H	0.29
HNSC	chr8	94671662	Missense_Mutation	novel	L481F	0.17
HNSC	chr8	94678235	Missense_Mutation	novel	P562S	0.23
HNSC	chr8	94671472	Missense_Mutation	rs760981296	S418L	0.28
HNSC	chr8	94665194	Missense_Mutation	novel	G310V	0.25
HNSC	chr8	94665195	Splice_Region	novel	G310G	0.24
HNSC	chr8	94641443	Missense_Mutation	novel	N42S	0.32
KIRC	chr8	94667999	Missense_Mutation	NA	V328L	0.09
KIRP	chr8	94641424	Nonsense_Mutation	novel	K36*	0.47
LGG	chr8	94668134	Missense_Mutation	NA	A373T	0.07
LGG	chr8	94671501	Missense_Mutation	novel	P428T	0.36
LIHC	chr8	94667985	Missense_Mutation	novel	E323G	0.37
LIHC	chr8	94674489	Missense_Mutation	novel	P545L	0.17
LIHC	chr8	94664700	Silent	NA	S216S	0.1
LIHC	chr8	94665046	Frame_Shift_Del	novel	*R293Gfs24**	0.32
LIHC	chr8	94642056	Missense_Mutation	rs752591294	A78E	0.06
LUAD	chr8	94641398	In_Frame_Del	novel	K28del	0.31
LUAD	chr8	94641314	5'UTR	novel		0.38
LUAD	chr8	94678244	Missense_Mutation	NA	V565L	0.34
LUAD	chr8	94678326	Missense_Mutation	novel	P592L	0.22
LUAD	chr8	94678326	Missense_Mutation	novel	P592L	0.36
LUAD	chr8	94674456	Missense_Mutation	novel	G534V	0.38
LUAD	chr8	94678277	Missense_Mutation	NA	S576P	0.37
LUAD	chr8	94646216	Missense_Mutation	NA	E142Q	0.18
LUAD	chr8	94664946	Missense_Mutation	NA	L259V	0.17
LUAD	chr8	94668250	Missense_Mutation	NA	Q411H	0.35
LUSC	chr8	94671513	Missense_Mutation	novel	V432L	0.08
LUSC	chr8	94674398	Missense_Mutation	novel	D515H	0.6
LUSC	chr8	94665162	Missense_Mutation	NA	K299N	0.11
LUSC	chr8	94674377	Missense_Mutation	NA	C508R	0.28
LUSC	chr8	94643395	Silent	novel	L118L	0.37
OV	chr8	94641962	Nonsense_Mutation	novel	Q47*	0.05
PRAD	chr8	94664762	Nonsense_Mutation	NA	S237*	0.27
PRAD	chr8	94668009	Missense_Mutation	NA	R331Q	0.27
READ	chr8	94646216	Nonsense_Mutation	NA	E142*	0.39
READ	chr8	94692731	Silent	rs369829287	S625S	0.42
READ	chr8	94643324	Nonsense_Mutation	NA	E95*	0.33
SARC	chr8	94641172	5'UTR	novel		0.08
SARC	chr8	94646222	Frame_Shift_Del	novel	*K144Rfs18**	0.48
SARC	chr8	94665048	Missense_Mutation	novel	R293W	0.2
SKCM	chr8	94667968	Silent	NA	A317A	0.44
SKCM	chr8	94674440	Missense_Mutation	novel	N529D	0.28
SKCM	chr8	94667975	Missense_Mutation	novel	L320F	0.26
SKCM	chr8	94668081	Missense_Mutation	novel	G355E	0.64
SKCM	chr8	94642066	Silent	novel	L81L	0.17
SKCM	chr8	94664762	Missense_Mutation	NA	S237L	0.25
SKCM	chr8	94671482	Silent	NA	L421L	0.14
SKCM	chr8	94668095	Missense_Mutation	novel	L360F	0.19
SKCM	chr8	94668129	Missense_Mutation	NA	G371E	0.25
SKCM	chr8	94671478	Missense_Mutation	novel	P420L	0.34
SKCM	chr8	94671645	Missense_Mutation	NA	G476R	0.39
SKCM	chr8	94668085	Silent	NA	K356K	0.16
SKCM	chr8	94668086	Missense_Mutation	NA	E357K	0.16
SKCM	chr8	94641254	5'UTR	novel		0.25
SKCM	chr8	94665180	Silent	NA	F305F	0.09
SKCM	chr8	94674483	Missense_Mutation	NA	S543F	0.46
SKCM	chr8	94668017	Missense_Mutation	NA	P334S	0.12
SKCM	chr8	94668086	Missense_Mutation	NA	E357K	0.34
SKCM	chr8	94668086	Missense_Mutation	NA	E357K	0.2
SKCM	chr8	94646241	Missense_Mutation	rs201610171	S150L	0.32
SKCM	chr8	94668115	Missense_Mutation	NA	D366E	0.32
SKCM	chr8	94671462	Nonsense_Mutation	NA	R415*	0.08
SKCM	chr8	94668143	Missense_Mutation	NA	L376F	0.2
SKCM	chr8	94671576	Missense_Mutation	NA	P453S	0.6
SKCM	chr8	94671463	Missense_Mutation	NA	R415Q	0.06
SKCM	chr8	94641988	Silent	NA	P55P	0.23
SKCM	chr8	94706095	3'UTR	novel		0.45
SKCM	chr8	94696859	Missense_Mutation	rs746129950	T660I	0.55
SKCM	chr8	94646211	Missense_Mutation	rs771325567	R140Q	0.09
SKCM	chr8	94668085	Silent	NA	K356K	0.1
SKCM	chr8	94641357	Silent	novel	G13G	0.27
SKCM	chr8	94662305	Missense_Mutation	NA	R175Q	0.11
SKCM	chr8	94705995	3'UTR	novel		0.27
SKCM	chr8	94671503	Silent	novel	P428P	0.15
SKCM	chr8	94641441	Silent	NA	A41A	0.41
SKCM	chr8	94664961	Nonsense_Mutation	NA	R264*	0.68
SKCM	chr8	94641971	Missense_Mutation	NA	E50K	0.53
SKCM	chr8	94664749	Missense_Mutation	rs776222018	P233S	0.15
STAD	chr8	94678218	Missense_Mutation	NA	S556F	0.22
STAD	chr8	94678264	Silent	NA	A571A	0.06
STAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.24
STAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.47
STAD	chr8	94668003	Missense_Mutation	NA	R329H	0.24
STAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.59
STAD	chr8	94641389	Missense_Mutation	novel	G24A	0.21
STAD	chr8	94671613	Frame_Shift_Ins	novel	*E467Gfs44**	0.31
STAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.5
STAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.67
STAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.64
STAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.27
STAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.41
STAD	chr8	94646263	Silent	rs376259698	D157D	0.18
STAD	chr8	94646282	Missense_Mutation	NA	Y164H	0.13
STAD	chr8	94692828	Splice_Site	novel	X657_splice	0.28
STAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.28
STAD	chr8	94668174	Missense_Mutation	NA	A386V	0.24
STAD	chr8	94641264	5'UTR	novel		0.33
STAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.38
STAD	chr8	94692826	Missense_Mutation	novel	Q657L	0.15
STAD	chr8	94678323	Missense_Mutation	NA	Y591C	0.18
STAD	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.27
STAD	chr8	94678259	Missense_Mutation	NA	A570T	0.12
STAD	chr8	94668134	Missense_Mutation	NA	A373T	0.1
TGCT	chr8	94643411	Missense_Mutation	novel	K124E	0.07
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.48
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.88
UCEC	chr8	94668190	Missense_Mutation	NA	K391N	0.33
UCEC	chr8	94696861	Missense_Mutation	rs775408778	E661K	0.33
UCEC	chr8	94641136	5'UTR	novel		0.36
UCEC	chr8	94662543	Missense_Mutation	rs760239537	E211G	0.41
UCEC	chr8	94664766	Silent	novel	D238D	0.31
UCEC	chr8	94646225	Missense_Mutation	NA	K145E	0.32
UCEC	chr8	94664791	Nonsense_Mutation	novel	G247*	0.06
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.71
UCEC	chr8	94671567	Nonsense_Mutation	NA	R450*	0.43
UCEC	chr8	94674470	Nonsense_Mutation	NA	R539*	0.44
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.95
UCEC	chr8	94674491	Missense_Mutation	novel	P546S	0.39
UCEC	chr8	94678317	Missense_Mutation	rs376569123	A589V	0.22
UCEC	chr8	94671462	Nonsense_Mutation	NA	R415*	0.22
UCEC	chr8	94641213	5'UTR	novel		0.51
UCEC	chr8	94646211	Missense_Mutation	rs771325567	R140Q	0.33
UCEC	chr8	94646216	Nonsense_Mutation	NA	E142*	0.06
UCEC	chr8	94646210	Nonsense_Mutation	NA	R140*	0.22
UCEC	chr8	94665058	Missense_Mutation	NA	E296V	0.23
UCEC	chr8	94668211	Nonsense_Mutation	NA	Y398*	0.31
UCEC	chr8	94674470	Nonsense_Mutation	NA	R539*	0.22
UCEC	chr8	94678316	Missense_Mutation	NA	A589T	0.25
UCEC	chr8	94706189	3'UTR	novel		0.13
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.6
UCEC	chr8	94662535	Frame_Shift_Ins	novel	*K209Sfs21**	0.04
UCEC	chr8	94706009	3'UTR	novel		0.4
UCEC	chr8	94706172	3'UTR	novel		0.25
UCEC	chr8	94678306	Silent	NA	Q585Q	0.21
UCEC	chr8	94665041	Missense_Mutation	NA	M290I	0.46
UCEC	chr8	94668077	Frame_Shift_Del	novel	*G355Efs33**	0.53
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.28
UCEC	chr8	94706660	3'UTR	novel		0.29
UCEC	chr8	94662354	Missense_Mutation	novel	M191I	0.27
UCEC	chr8	94671567	Nonsense_Mutation	NA	R450*	0.45
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.43
UCEC	chr8	94706542	3'UTR	novel		0.4
UCEC	chr8	94674400	Silent	rs777955065	D515D	0.18
UCEC	chr8	94671623	Silent	rs565423201	F468F	0.38
UCEC	chr8	94692731	Silent	rs369829287	S625S	0.49
UCEC	chr8	94674382	Frame_Shift_Ins	NA	*N512Kfs8**	0.32
UCEC	chr8	94671562	Missense_Mutation	novel	R448H	0.07
UCEC	chr8	94696851	Splice_Site	novel	X658_splice	0.19
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.27
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.28
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.37
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.95
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.51
UCEC	chr8	94664740	Nonsense_Mutation	NA	R230*	0.14
UCEC	chr8	94646216	Nonsense_Mutation	NA	E142*	0.82
UCEC	chr8	94692688	Missense_Mutation	novel	S611L	0.31
UCEC	chr8	94671637	Missense_Mutation	rs772941059	R473H	0.48
UCEC	chr8	94641288	5'UTR	rs757019926		0.33
UCEC	chr8	94668221	Missense_Mutation	novel	F402L	0.22
UCEC	chr8	94671567	Nonsense_Mutation	NA	R450*	0.34
UCEC	chr8	94642028	Frame_Shift_Del	novel	I70*	0.22
UCEC	chr8	94668231	Missense_Mutation	novel	T405I	0.13
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.57
UCEC	chr8	94696931	3'UTR	novel		0.38
UCEC	chr8	94646216	Nonsense_Mutation	NA	E142*	0.31
UCEC	chr8	94662273	Nonsense_Mutation	novel	Y164*	0.21
UCEC	chr8	94665177	Missense_Mutation	novel	D304E	0.32
UCEC	chr8	94662304	Nonsense_Mutation	NA	R175*	0.15
UCEC	chr8	94696909	Nonsense_Mutation	NA	E677*	0.14
UCEC	chr8	94646216	Nonsense_Mutation	NA	E142*	0.34
UCEC	chr8	94671636	Missense_Mutation	NA	R473C	0.27
UCEC	chr8	94643399	Missense_Mutation	novel	P120T	0.44
UCEC	chr8	94646273	Missense_Mutation	rs762910489	M161V	0.31
UCEC	chr8	94662371	Splice_Site	novel	X197_splice	0.29
UCEC	chr8	94668211	Nonsense_Mutation	NA	Y398*	0.28
UCEC	chr8	94671563	Silent	novel	R448R	0.31
UCEC	chr8	94668174	Missense_Mutation	NA	A386V	0.34
UCEC	chr8	94641217	5'UTR	novel		0.35
UCEC	chr8	94668077	Frame_Shift_Del	novel	*G355Efs33**	0.27
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.5
UCEC	chr8	94674382	Frame_Shift_Ins	NA	*N512Kfs8**	0.35
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.86
UCEC	chr8	94664754	Nonsense_Mutation	NA	W234*	0.57
UCEC	chr8	94641970	Silent	rs377762593	H49H	0.5
UCEC	chr8	94641447	Silent	rs371931710	K43K	0.32
UCEC	chr8	94641230	5'UTR	novel		0.15
UCEC	chr8	94646211	Missense_Mutation	rs771325567	R140Q	0.15
UCEC	chr8	94646275	Missense_Mutation	novel	M161I	0.38
UCEC	chr8	94696958	3'UTR	novel		0.42
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.31
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.45
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.51
UCEC	chr8	94646252	Missense_Mutation	novel	D154N	0.28
UCEC	chr8	94674383	Frame_Shift_Del	rs775950025	*N512Tfs2**	0.97
UCS	chr8	94641247	5'UTR	novel		0.32
UCS	chr8	94664741	Missense_Mutation	NA	R230Q	0.12

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.1023	0.15559
PRAD	AMP	0.2602	3.7005e-05
SARC	AMP	0.2918	0.18425
TGCT	AMP	0.66	0.13696
THCA	DEL	0.008	0.038162

Survival Analysis

Cancer	P-value	Q-value
THYM	0.016	Kaplan-Meier Survival Analysis
ACC	0.0016	Kaplan-Meier Survival Analysis
SKCM	0.00051	Kaplan-Meier Survival Analysis
BRCA	0.0042	Kaplan-Meier Survival Analysis
KIRP	0.047	Kaplan-Meier Survival Analysis
COAD	0.05	Kaplan-Meier Survival Analysis
PAAD	0.00011	Kaplan-Meier Survival Analysis
LAML	0.0042	Kaplan-Meier Survival Analysis
UCEC	0.00054	Kaplan-Meier Survival Analysis
LUAD	0.048	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000104413 (Gene tree)
Gene ID: 54845
Gene Symbol: ESRP1
Alias: RBM35A|DFNB109
Full Name: Epithelial Splicing Regulatory Protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 66,393 bases
Position: chr8:94,641,074-94,707,466
Accession: 25966
RBP type: non-canonical RBP
Summary: ESRP1 (Epithelial Splicing Regulatory Protein 1) is a Protein Coding gene. Diseases associated with ESRP1 include Deafness, Autosomal Recessive 109. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and mRNA binding. An important paralog of this gene is ESRP2.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19177006	RNA-binding motif protein 35A is a novel tumor suppressor for colorectal cancer.	Cell Cycle	2009 Feb 1	Leontieva OV	-
31131921	Small molecule inhibitors of epithelial-mesenchymal transition for the treatment of cancer and fibrosis.	Med Res Rev	2019 May 27	Feng YL	doi: 10.1002/med.21596
19829082	The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events.	RNA Biol	2009 Nov-Dec	Warzecha CC	-
20348248	Genetic and epigenetic mechanisms down-regulate FGF receptor 2 to induce melanoma-associated antigen A in breast cancer.	Am J Pathol	2010 May	Zhu X	doi: 10.2353/ajpath.2010.091049
25512611	A posttranscriptional mechanism that controls Ptbp1 abundance in the Xenopus epidermis.	Mol Cell Biol	2015 Feb	Mereau A	doi: 10.1128/MCB.01040-14
27682981	Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events.	J Cell Physiol	2017 Jun	Matos ML	doi: 10.1002/jcp.25622
24015231	The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells.	PLoS One	2013 Aug 27	Fagoonee S	doi: 10.1371/journal.pone.0072300
28052020	The RNA-binding protein ESRP1 promotes human colorectal cancer progression.	Oncotarget	2017 Feb 7	Fagoonee S	doi: 10.18632/oncotarget.14318.
27108394	Epithelial Splicing Regulatory Protein 1 (ESRP1) is a new regulator of stomach smooth muscle development and plasticity.	Dev Biol	2016 Jun 15	Sagnol S	doi: 10.1016/j.ydbio.2016.04.015
28634384	Alternative splicing regulates distinct subcellular localization of Epithelial splicing regulatory protein 1 (Esrp1) isoforms.	Sci Rep	2017 Jun 20	Yang Y	doi: 10.1038/s41598-017-03180-3.
29803834	Epithelial Splicing Regulatory Protein 1 Inhibits the Invasion and Metastasis of Lung Adenocarcinoma.	Am J Pathol	2018 Aug	Li L	doi: 10.1016/j.ajpath.2018.04.012
22354987	Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing.	Mol Cell Biol	2012 Apr	Dittmar KA	doi: 10.1128/MCB.06536-11

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000358397	ESRP1-201	3756	-	ENSP00000351168	677 (aa)	-	Q6NXG1
ENST00000522756	ESRP1-209	609	-	ENSP00000428490	40 (aa)	-	E5RI26
ENST00000522920	ESRP1-210	402	-	-	- (aa)	-	-
ENST00000642581	ESRP1-212	3782	-	ENSP00000495733	681 (aa)	-	Q6NXG1
ENST00000646773	ESRP1-213	3274	-	ENSP00000494213	608 (aa)	-	Q6NXG1
ENST00000433389	ESRP1-203	3806	XM_005250992	ENSP00000405738	681 (aa)	XP_005251049	Q6NXG1
ENST00000519505	ESRP1-207	3068	-	ENSP00000430118	502 (aa)	-	H0YBR2
ENST00000423620	ESRP1-202	3746	XM_005250991	ENSP00000407349	659 (aa)	XP_005251048	Q6NXG1
ENST00000517610	ESRP1-206	2139	-	ENSP00000429125	522 (aa)	-	H0YBB3
ENST00000520385	ESRP1-208	764	-	-	- (aa)	-	-
ENST00000517556	ESRP1-205	457	-	-	- (aa)	-	-
ENST00000454170	ESRP1-204	3465	-	ENSP00000402766	604 (aa)	-	A0A2U3TZN9
ENST00000523347	ESRP1-211	1813	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000104413's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104413's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000104413	ESRP1	100	97.269	ENSMUSG00000040728	Esrp1	100	97.269	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003729	mRNA binding	19285943.	IDA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	19285943.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0042669	regulation of inner ear auditory receptor cell fate specification	-	ISS	Process
GO:0043484	regulation of RNA splicing	19285943.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.