EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28856538	UBR5 Contributes to Colorectal Cancer Progression by Destabilizing the Tumor Suppressor ECRG4.	Dig Dis Sci	2017 Oct	Wang J	doi: 10.1007/s10620-017-4732-6
28330927	E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer.	Cancer Res	2017 Apr 15	Liao L	doi: 10.1158/0008-5472.CAN-16-2409
27590582	The E3 ligase UBR5 regulates gastric cancer cell growth by destabilizing the tumor suppressor GKN1.	Biochem Biophys Res Commun	2016 Sep 30	Yang M	doi: 10.1016/j.bbrc.2016.08.170
29441938	UBR5 promotes cell proliferation and inhibits apoptosis in colon cancer by destablizing P21.	Pharmazie	2017 Jul 3	Ji SQ	doi: 10.1691/ph.2017.7433.
26234678	E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60.	Oncogene	2016 Apr 21	Subbaiah VK	doi: 10.1038/onc.2015.268
26464214	Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer.	Mol Cancer Res	2015 Dec	Shearer RF	doi: 10.1158/1541-7786.MCR-15-0383
24379240	EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer.	Carcinogenesis	2014 May	Bradley A	doi: 10.1093/carcin/bgt489
18073532	The E3 ubiquitin ligase EDD regulates S-phase and G(2)/M DNA damage checkpoints.	Cell Cycle	2007 Dec 15	Munoz MA	-
17074762	EDD mediates DNA damage-induced activation of CHK2.	J Biol Chem	2006 Dec 29	Henderson MJ	-
18349819	The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro.	Br J Cancer	2008 Mar 25	O'Brien PM	doi: 10.1038/sj.bjc.6604281
24441042	Systems level-based RNAi screening by high content analysis identifies UBR5 as a regulator of estrogen receptor-α protein levels and activity.	Oncogene	2015 Jan 8	Bolt MJ	doi: 10.1038/onc.2013.550
21949371	A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis.	Proc Natl Acad Sci U S A	2011 Oct 25	Dompe N	doi: 10.1073/pnas.1100132108
27721409	Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.	Oncogene	2017 Mar 23	Matsuura K	doi: 10.1038/onc.2016.336
28332316	GOLPH3 induces epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway in epithelial ovarian cancer.	Cancer Med	2017 Apr	Sun J	doi: 10.1002/cam4.1040

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.54
ACC	chr8	102285771	Silent	rs761737763	A1742A	0.45
ACC	chr8	102272709	Silent	novel	R2265R	0.52
ACC	chr8	102285712	Missense_Mutation	novel	A1762D	0.9
BLCA	chr8	102295779	Silent	NA	L1223L	0.18
BLCA	chr8	102289522	Silent	NA	I1548I	0.09
BLCA	chr8	102312240	Silent	novel	V719V	0.48
BLCA	chr8	102312472	Missense_Mutation	novel	D674G	0.28
BLCA	chr8	102275537	Missense_Mutation	novel	R2238T	0.07
BLCA	chr8	102342478	Missense_Mutation	NA	D365H	0.14
BLCA	chr8	102261912	Splice_Region	novel		0.2
BLCA	chr8	102286371	Missense_Mutation	NA	S1735C	0.07
BLCA	chr8	102346956	Missense_Mutation	NA	Q175E	0.17
BLCA	chr8	102272565	Missense_Mutation	novel	E2313Q	0.15
BLCA	chr8	102323318	Missense_Mutation	NA	E593K	0.13
BLCA	chr8	102278868	Silent	novel	G2082G	0.4
BLCA	chr8	102360105	Missense_Mutation	novel	E118Q	0.08
BLCA	chr8	102299506	Missense_Mutation	novel	L1050V	0.13
BLCA	chr8	102327818	Missense_Mutation	novel	Q469K	0.27
BLCA	chr8	102265247	Missense_Mutation	NA	R2485Q	0.56
BLCA	chr8	102329346	Silent	NA	V384V	0.08
BLCA	chr8	102272749	Silent	novel	L2251L	0.56
BLCA	chr8	102278921	Missense_Mutation	novel	D2065N	0.06
BLCA	chr8	102289503	Missense_Mutation	novel	R1555W	0.15
BLCA	chr8	102293623	Missense_Mutation	NA	S1524L	0.35
BLCA	chr8	102278852	Missense_Mutation	novel	V2088F	0.05
BLCA	chr8	102254475	Missense_Mutation	rs745620207	E2743K	0.21
BLCA	chr8	102278828	Missense_Mutation	novel	E2096Q	0.05
BLCA	chr8	102298871	Silent	novel	Y1101Y	0.38
BLCA	chr8	102285540	Missense_Mutation	novel	L1819F	0.05
BLCA	chr8	102326644	Frame_Shift_Ins	novel	*Q501Kfs10**	0.19
BLCA	chr8	102254450	Missense_Mutation	novel	S2751L	0.13
BLCA	chr8	102311747	Silent	NA	F802F	0.53
BLCA	chr8	102361622	Missense_Mutation	NA	R23G	0.07
BLCA	chr8	102345509	Missense_Mutation	NA	S258F	0.35
BLCA	chr8	102361621	Missense_Mutation	NA	R23Q	0.35
BLCA	chr8	102254302	Nonstop_Mutation	novel	2800Yext42	0.11
BLCA	chr8	102265224	Missense_Mutation	NA	D2493H	0.68
BLCA	chr8	102275579	Missense_Mutation	novel	K2224I	0.19
BRCA	chr8	102312353	Missense_Mutation	novel	D714N	0.18
BRCA	chr8	102259034	Silent	novel	E2684E	0.09
BRCA	chr8	102272652	Missense_Mutation	NA	E2284K	0.2
BRCA	chr8	102272551	Missense_Mutation	NA	N2317K	0.16
BRCA	chr8	102285179	Missense_Mutation	NA	E1882K	0.19
BRCA	chr8	102347077	Silent	rs547851962	S134S	0.09
BRCA	chr8	102312173	Missense_Mutation	novel	E742K	0.1
BRCA	chr8	102275720	Silent	NA	A2206A	0.15
BRCA	chr8	102295234	Missense_Mutation	NA	I1343N	0.2
BRCA	chr8	102300121	Silent	novel	S995S	0.06
BRCA	chr8	102323487	Missense_Mutation	NA	L536F	0.22
BRCA	chr8	102287467	Silent	NA	S1641S	0.19
BRCA	chr8	102289527	Missense_Mutation	rs758390848	R1547C	0.07
BRCA	chr8	102278929	Missense_Mutation	NA	R2062K	0.19
BRCA	chr8	102272673	Missense_Mutation	NA	V2277I	0.21
BRCA	chr8	102285199	Missense_Mutation	novel	S1875F	0.18
BRCA	chr8	102323415	Silent	novel	V560V	0.12
BRCA	chr8	102314843	Missense_Mutation	novel	K599Q	0.08
BRCA	chr8	102264481	Missense_Mutation	novel	G2560V	0.08
BRCA	chr8	102270172	Missense_Mutation	novel	R2366I	0.11
BRCA	chr8	102311442	Missense_Mutation	NA	D825Y	0.13
BRCA	chr8	102361622	Missense_Mutation	NA	R23G	0.06
BRCA	chr8	102296936	Missense_Mutation	novel	C1208G	0.07
BRCA	chr8	102296938	Nonsense_Mutation	novel	C1207*	0.07
BRCA	chr8	102360640	Nonsense_Mutation	novel	F72*	0.04
BRCA	chr8	102346911	Missense_Mutation	novel	I190F	0.06
BRCA	chr8	102277062	Missense_Mutation	novel	S2140F	0.07
BRCA	chr8	102285602	Missense_Mutation	NA	M1799V	0.18
BRCA	chr8	102261929	Missense_Mutation	NA	E2610K	0.25
BRCA	chr8	102281379	Missense_Mutation	novel	H1946L	0.11
BRCA	chr8	102297581	Silent	NA	E1150E	0.89
CESC	chr8	102286576	Missense_Mutation	novel	Q1667E	0.21
CESC	chr8	102304097	Missense_Mutation	novel	S967L	0.23
CESC	chr8	102272624	Missense_Mutation	novel	R2293Q	0.27
CESC	chr8	102329193	Missense_Mutation	NA	S408L	0.51
CESC	chr8	102323487	Missense_Mutation	novel	L536F	0.26
CESC	chr8	102295203	Splice_Site	NA	X1353_splice	0.26
CESC	chr8	102253924	3'UTR	novel		0.37
CESC	chr8	102287529	Missense_Mutation	NA	E1621K	0.2
CESC	chr8	102346367	Missense_Mutation	NA	R202K	0.43
CESC	chr8	102253702	3'UTR	novel		0.4
CESC	chr8	102275770	Missense_Mutation	NA	R2190C	0.38
CESC	chr8	102305268	Missense_Mutation	rs138913761	R882C	0.37
CESC	chr8	102326600	Frame_Shift_Ins	novel	*P516Afs2**	0.34
CESC	chr8	102412175	Splice_Region	novel	D20D	0.39
CESC	chr8	102346332	Missense_Mutation	NA	L214V	0.29
CESC	chr8	102275791	Missense_Mutation	novel	D2183N	0.08
CESC	chr8	102277090	Missense_Mutation	novel	E2131Q	0.58
CESC	chr8	102253559	3'UTR	novel		0.61
CESC	chr8	102346907	Missense_Mutation	NA	S191L	0.64
CESC	chr8	102253564	3'UTR	novel		0.24
CESC	chr8	102326574	Missense_Mutation	rs780581220	S524L	0.16
CHOL	chr8	102311415	Missense_Mutation	novel	D834N	0.4
COAD	chr8	102345393	Splice_Region	novel		0.44
COAD	chr8	102360132	Missense_Mutation	NA	D109N	0.4
COAD	chr8	102265269	Nonsense_Mutation	NA	R2478*	0.1
COAD	chr8	102296968	Missense_Mutation	rs748469481	R1197Q	0.07
COAD	chr8	102254355	Missense_Mutation	novel	L2783I	0.49
COAD	chr8	102304046	Missense_Mutation	NA	R984Q	0.1
COAD	chr8	102267142	Intron	novel		0.41
COAD	chr8	102275770	Missense_Mutation	NA	R2190C	0.36
COAD	chr8	102262044	Frame_Shift_Del	NA	*F2571Lfs4**	0.34
COAD	chr8	102295271	Missense_Mutation	NA	R1331C	0.28
COAD	chr8	102254198	3'UTR	novel		0.3
COAD	chr8	102295436	Silent	novel	N1303N	0.32
COAD	chr8	102295222	Missense_Mutation	novel	S1347L	0.13
COAD	chr8	102280397	Missense_Mutation	novel	Q2000E	0.08
COAD	chr8	102299518	Frame_Shift_Ins	novel	*A1046Rfs49**	0.21
COAD	chr8	102295203	Splice_Site	NA	X1353_splice	0.18
COAD	chr8	102279105	Missense_Mutation	NA	I2035M	0.26
COAD	chr8	102347034	Missense_Mutation	NA	A149T	0.19
COAD	chr8	102360154	Silent	rs150186712	T101T	0.21
COAD	chr8	102311856	Missense_Mutation	novel	V766A	0.64
COAD	chr8	102277120	Frame_Shift_Ins	NA	*E2121Rfs13**	0.28
COAD	chr8	102278913	Frame_Shift_Del	NA	*F2067Lfs19**	0.28
COAD	chr8	102262044	Frame_Shift_Del	NA	*F2571Lfs4**	0.28
COAD	chr8	102285146	Nonsense_Mutation	NA	R1893*	0.26
COAD	chr8	102254197	3'UTR	novel		0.31
COAD	chr8	102342641	Missense_Mutation	NA	E310D	0.19
COAD	chr8	102277121	Frame_Shift_Del	NA	*K2120Rfs13**	0.24
COAD	chr8	102342645	Missense_Mutation	novel	R309H	0.11
COAD	chr8	102347024	Missense_Mutation	NA	R152Q	0.34
COAD	chr8	102254292	3'UTR	novel		0.38
COAD	chr8	102275824	Nonsense_Mutation	novel	Q2172*	0.08
COAD	chr8	102300046	Frame_Shift_Del	NA	I1021*	0.41
COAD	chr8	102295271	Missense_Mutation	NA	R1331C	0.18
COAD	chr8	102326624	Missense_Mutation	NA	E507D	0.1
COAD	chr8	102259036	Missense_Mutation	NA	E2684K	0.32
COAD	chr8	102300045	Frame_Shift_Ins	NA	*I1021Hfs5**	0.23
COAD	chr8	102272734	Missense_Mutation	novel	M2256I	0.17
COAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.39
COAD	chr8	102265171	Silent	novel	K2510K	0.26
COAD	chr8	102280464	Silent	rs748248735	T1977T	0.19
COAD	chr8	102342618	Missense_Mutation	rs566868823	R318H	0.36
DLBC	chr8	102297545	Silent	novel	G1162G	0.3
DLBC	chr8	102257675	Nonsense_Mutation	NA	W2715*	0.53
DLBC	chr8	102254424	Nonsense_Mutation	novel	Q2760*	0.11
ESCA	chr8	102257685	Missense_Mutation	novel	R2712C	0.77
ESCA	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.28
ESCA	chr8	102259040	Silent	rs754064392	C2682C	0.07
ESCA	chr8	102296975	Frame_Shift_Ins	novel	E1195*	0.1
ESCA	chr8	102261972	Missense_Mutation	novel	F2595L	0.18
ESCA	chr8	102271221	Missense_Mutation	novel	R2333Q	0.31
ESCA	chr8	102253666	3'UTR	novel		0.33
GBM	chr8	102288207	Silent	rs200315433	H1591H	0.44
GBM	chr8	102285692	Missense_Mutation	novel	L1769V	0.1
GBM	chr8	102287466	Missense_Mutation	novel	V1642I	0.29
GBM	chr8	102261164	Silent	novel	V2646V	0.16
GBM	chr8	102285216	Missense_Mutation	novel	N1869K	0.08
GBM	chr8	102342571	Missense_Mutation	novel	S334A	0.22
GBM	chr8	102286406	Missense_Mutation	novel	H1723Q	0.08
GBM	chr8	102275610	Nonsense_Mutation	novel	E2214*	0.41
GBM	chr8	102294990	Missense_Mutation	novel	D1394N	0.13
GBM	chr8	102346915	Silent	rs770087135	E188E	0.13
GBM	chr8	102329097	Missense_Mutation	novel	N440T	0.04
GBM	chr8	102327870	Frame_Shift_Ins	novel	*L451Ffs7**	0.33
GBM	chr8	102286407	Missense_Mutation	novel	H1723R	0.09
GBM	chr8	102254340	Silent	NA	L2788L	0.1
GBM	chr8	102285152	Missense_Mutation	novel	S1891G	0.04
GBM	chr8	102285695	Missense_Mutation	NA	A1768P	0.44
HNSC	chr8	102285534	Nonsense_Mutation	novel	Y1821*	0.13
HNSC	chr8	102293736	Silent	novel	V1486V	0.19
HNSC	chr8	102281426	Silent	novel	D1930D	0.08
HNSC	chr8	102346994	Missense_Mutation	rs753343861	R162Q	0.24
HNSC	chr8	102289471	Silent	novel	V1565V	0.2
HNSC	chr8	102326569	Missense_Mutation	novel	P526S	0.11
HNSC	chr8	102342676	Missense_Mutation	novel	L299V	0.08
HNSC	chr8	102323383	Missense_Mutation	novel	S571I	0.23
HNSC	chr8	102293607	Splice_Region	novel	S1529S	0.1
HNSC	chr8	102269009	Nonsense_Mutation	novel	E2444*	0.18
HNSC	chr8	102347054	Missense_Mutation	novel	G142E	0.24
HNSC	chr8	102342477	Missense_Mutation	novel	D365G	0.47
HNSC	chr8	102312450	Silent	novel	K681K	0.05
HNSC	chr8	102266982	Missense_Mutation	novel	D2463H	0.12
HNSC	chr8	102347066	Missense_Mutation	novel	G138A	0.07
HNSC	chr8	102305145	Silent	novel	L923L	0.18
HNSC	chr8	102275741	Silent	novel	V2199V	0.27
HNSC	chr8	102281423	Silent	novel	E1931E	0.16
HNSC	chr8	102346992	Missense_Mutation	novel	T163S	0.11
HNSC	chr8	102346275	Missense_Mutation	novel	D233N	0.07
HNSC	chr8	102276974	Splice_Region	novel	F2169F	0.21
HNSC	chr8	102311301	Missense_Mutation	novel	E872Q	0.2
HNSC	chr8	102313918	Splice_Site	novel	X632_splice	0.26
HNSC	chr8	102296932	Missense_Mutation	rs764816360	T1209M	0.11
HNSC	chr8	102346271	Missense_Mutation	novel	G234V	0.4
HNSC	chr8	102361138	Missense_Mutation	novel	A59V	0.18
HNSC	chr8	102279080	Silent	novel	L2044L	0.06
HNSC	chr8	102298477	Silent	novel	G1113G	0.25
HNSC	chr8	102342586	Missense_Mutation	novel	D329H	0.06
KICH	chr8	102312401	Missense_Mutation	novel	D698H	0.07
KICH	chr8	102265269	Nonsense_Mutation	NA	R2478*	0.04
KIRC	chr8	102329356	Frame_Shift_Del	novel	*E380Sfs6**	0.06
KIRC	chr8	102285298	Missense_Mutation	NA	M1842T	0.28
KIRC	chr8	102314780	Missense_Mutation	rs796264766	A620T	0.26
KIRC	chr8	102329370	Silent	NA	A376A	0.19
KIRC	chr8	102329092	Frame_Shift_Del	novel	*N440Kfs8**	0.39
KIRC	chr8	102262054	Missense_Mutation	NA	F2568Y	0.12
KIRP	chr8	102275730	Missense_Mutation	NA	D2203G	0.1
KIRP	chr8	102261245	Silent	novel	P2619P	0.4
KIRP	chr8	102254499	Missense_Mutation	novel	S2735T	0.34
KIRP	chr8	102289542	Missense_Mutation	novel	N1542H	0.25
KIRP	chr8	102285270	Silent	novel	A1851A	0.04
LAML	chr8	102277120	Frame_Shift_Ins	NA	*E2121Rfs13**	0.34
LAML	chr8	102288250	Frame_Shift_Del	novel	*G1577Vfs41**	0.04
LAML	chr8	102361194	Frame_Shift_Ins	novel	*L40Ffs10**	0.12
LGG	chr8	102285673	Missense_Mutation	NA	S1775N	0.2
LGG	chr8	102347056	Silent	novel	G141G	0.44
LGG	chr8	102254452	Silent	NA	P2750P	0.13
LGG	chr8	102257674	Nonsense_Mutation	novel	W2715*	0.06
LGG	chr8	102254398	Silent	rs748361831	C2768C	0.41
LGG	chr8	102275808	Missense_Mutation	novel	G2177E	0.28
LGG	chr8	102314838	Missense_Mutation	novel	Q600H	0.5
LGG	chr8	102329088	Splice_Site	novel	X442_splice	0.39
LGG	chr8	102342631	Missense_Mutation	novel	V314I	0.32
LGG	chr8	102323411	Missense_Mutation	rs753988129	M562V	0.36
LGG	chr8	102293683	Frame_Shift_Del	novel	*I1504Kfs114**	0.08
LGG	chr8	102293684	Missense_Mutation	novel	I1504L	0.08
LIHC	chr8	102323487	Missense_Mutation	novel	L536F	0.22
LIHC	chr8	102267033	Intron	novel		0.19
LIHC	chr8	102257708	Missense_Mutation	NA	A2704V	0.08
LIHC	chr8	102288252	Silent	NA	E1576E	0.25
LIHC	chr8	102267023	Intron	novel		0.5
LIHC	chr8	102279196	Missense_Mutation	novel	N2005I	0.22
LIHC	chr8	102311815	Missense_Mutation	NA	Q780E	0.14
LUAD	chr8	102281428	Missense_Mutation	NA	D1930N	0.23
LUAD	chr8	102278929	Missense_Mutation	NA	R2062T	0.05
LUAD	chr8	102254453	Missense_Mutation	NA	P2750L	0.06
LUAD	chr8	102289494	Missense_Mutation	novel	D1558Y	0.54
LUAD	chr8	102305182	Silent	rs777856300	T910T	0.53
LUAD	chr8	102314780	Missense_Mutation	NA	A620S	0.59
LUAD	chr8	102277011	Missense_Mutation	NA	G2157E	0.09
LUAD	chr8	102277012	Missense_Mutation	novel	G2157R	0.09
LUAD	chr8	102305160	Missense_Mutation	novel	G918R	0.34
LUAD	chr8	102296938	Missense_Mutation	NA	C1207F	0.62
LUAD	chr8	102275734	Nonsense_Mutation	NA	E2202*	0.63
LUAD	chr8	102304119	Missense_Mutation	NA	E960K	0.25
LUAD	chr8	102327770	Missense_Mutation	novel	A485S	0.51
LUAD	chr8	102286435	Missense_Mutation	novel	M1714L	0.25
LUAD	chr8	102346293	Missense_Mutation	novel	D227N	0.06
LUAD	chr8	102277165	Missense_Mutation	novel	A2106T	0.28
LUAD	chr8	102261245	Silent	novel	P2619P	0.15
LUAD	chr8	102326663	Missense_Mutation	novel	W494C	0.12
LUAD	chr8	102270072	Missense_Mutation	NA	E2399D	0.2	PABP
LUAD	chr8	102294108	Missense_Mutation	novel	D1399V	0.14
LUAD	chr8	102342481	Missense_Mutation	novel	P364S	0.26
LUAD	chr8	102304166	Missense_Mutation	rs748984520	A944V	0.15
LUAD	chr8	102285741	Missense_Mutation	novel	L1752F	0.28
LUAD	chr8	102345413	Missense_Mutation	novel	R290M	0.17
LUAD	chr8	102312477	Missense_Mutation	NA	K672N	0.35
LUAD	chr8	102299525	Silent	novel	L1043L	0.35
LUAD	chr8	102346238	Missense_Mutation	novel	G245E	0.08
LUAD	chr8	102286392	Missense_Mutation	novel	S1728I	0.16
LUAD	chr8	102304167	Missense_Mutation	novel	A944T	0.24
LUAD	chr8	102347067	Nonsense_Mutation	NA	G138*	0.43
LUAD	chr8	102285164	Nonsense_Mutation	NA	R1887*	0.1
LUAD	chr8	102254483	Missense_Mutation	NA	P2740L	0.1
LUAD	chr8	102275568	Missense_Mutation	NA	E2228K	0.16
LUAD	chr8	102329179	Missense_Mutation	novel	R413G	0.2
LUAD	chr8	102286545	Missense_Mutation	rs767084751	S1677N	0.36
LUAD	chr8	102272655	Missense_Mutation	novel	D2283Y	0.11
LUSC	chr8	102311875	Missense_Mutation	novel	L760V	0.17
LUSC	chr8	102346255	Silent	rs768814975	S239S	0.16
LUSC	chr8	102312412	Missense_Mutation	NA	S694I	0.44
LUSC	chr8	102293635	Missense_Mutation	novel	P1520L	0.06
LUSC	chr8	102297564	Missense_Mutation	novel	G1156E	0.23
LUSC	chr8	102272615	Missense_Mutation	NA	Y2296C	0.33
LUSC	chr8	102277042	Nonsense_Mutation	novel	Q2147*	0.38
LUSC	chr8	102296896	Missense_Mutation	NA	C1221F	0.39
LUSC	chr8	102294094	Missense_Mutation	NA	T1404S	0.13
LUSC	chr8	102285287	Missense_Mutation	NA	M1846V	0.56
LUSC	chr8	102293626	Missense_Mutation	novel	P1523L	0.25
LUSC	chr8	102327798	Silent	NA	S475S	0.08
LUSC	chr8	102287471	Missense_Mutation	NA	R1640T	0.2
LUSC	chr8	102342514	Missense_Mutation	novel	P353A	0.13
LUSC	chr8	102281501	Missense_Mutation	novel	S1905R	0.07
LUSC	chr8	102289551	Missense_Mutation	NA	I1539V	0.13
LUSC	chr8	102305254	Missense_Mutation	novel	E886D	0.12
LUSC	chr8	102287474	Missense_Mutation	NA	R1639P	0.39
LUSC	chr8	102254498	Nonsense_Mutation	novel	S2735*	0.05
LUSC	chr8	102270030	Splice_Site	novel	X2403_splice	0.13
LUSC	chr8	102275587	Missense_Mutation	novel	K2221N	0.51
LUSC	chr8	102300019	Silent	NA	D1029D	0.37
LUSC	chr8	102277022	Silent	novel	L2153L	0.13
LUSC	chr8	102257649	Missense_Mutation	novel	T2724A	0.23
LUSC	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.13
LUSC	chr8	102278852	Missense_Mutation	novel	V2088I	0.11
LUSC	chr8	102277150	Missense_Mutation	novel	V2111I	0.19
LUSC	chr8	102327789	Silent	novel	C478C	0.33
LUSC	chr8	102279139	Missense_Mutation	novel	R2024L	0.19
LUSC	chr8	102285215	Missense_Mutation	novel	H1870Y	0.33
LUSC	chr8	102262022	Silent	NA	L2579L	0.07
OV	chr8	102342636	Missense_Mutation	NA	E312A	0.21
OV	chr8	102305223	Missense_Mutation	NA	Q897K	0.55
OV	chr8	102346914	Missense_Mutation	novel	L189V	0.1
OV	chr8	102265223	Missense_Mutation	NA	D2493V	0.42
OV	chr8	102298960	In_Frame_Del	novel	G1068_T1071del	0.14
OV	chr8	102259027	Missense_Mutation	NA	V2687M	0.54
OV	chr8	102278932	Missense_Mutation	novel	A2061G	0.09
OV	chr8	102275591	Missense_Mutation	novel	V2220E	0.07
OV	chr8	102300133	Missense_Mutation	novel	M991I	0.15
OV	chr8	102286584	Missense_Mutation	NA	D1664G	0.4
OV	chr8	102342534	Missense_Mutation	rs767658152	K346R	0.53
OV	chr8	102305244	Missense_Mutation	novel	Q890E	0.09
OV	chr8	102311497	Splice_Site	NA	X807_splice	0.25
OV	chr8	102288163	Missense_Mutation	novel	D1606A	0.04
PAAD	chr8	102254382	Missense_Mutation	novel	V2774I	0.21
PAAD	chr8	102262039	Missense_Mutation	novel	P2573H	0.19
PAAD	chr8	102295678	Missense_Mutation	novel	R1257H	0.05
PAAD	chr8	102326652	Missense_Mutation	novel	P498L	0.13
PAAD	chr8	102345455	Missense_Mutation	novel	S276I	0.17
PRAD	chr8	102279140	Nonsense_Mutation	NA	R2024*	0.08
PRAD	chr8	102281440	Missense_Mutation	NA	R1926W	0.47
PRAD	chr8	102298457	Missense_Mutation	novel	A1120V	0.43
PRAD	chr8	102305213	Missense_Mutation	novel	V900A	0.38
READ	chr8	102295215	Silent	NA	E1349E	0.21
READ	chr8	102254434	Silent	NA	P2756P	0.69
READ	chr8	102279137	Missense_Mutation	novel	R2025C	0.2
READ	chr8	102346307	Missense_Mutation	novel	N222T	0.04
READ	chr8	102305233	Missense_Mutation	novel	M893I	0.39
READ	chr8	102342533	Missense_Mutation	novel	K346N	0.42
READ	chr8	102361608	Missense_Mutation	novel	E27D	0.38
READ	chr8	102281341	Missense_Mutation	NA	K1959E	0.1
READ	chr8	102345462	Missense_Mutation	novel	D274Y	0.36
SARC	chr8	102253459	3'UTR	novel		0.48
SKCM	chr8	102281395	Missense_Mutation	NA	V1941I	0.42
SKCM	chr8	102311490	Missense_Mutation	NA	P809S	0.31
SKCM	chr8	102327821	Missense_Mutation	rs778304413	L468F	0.37
SKCM	chr8	102277185	Missense_Mutation	novel	P2099L	0.33
SKCM	chr8	102278918	Missense_Mutation	NA	L2066F	0.27
SKCM	chr8	102300135	Missense_Mutation	novel	M991L	0.14
SKCM	chr8	102312446	Missense_Mutation	NA	P683S	0.34
SKCM	chr8	102265247	Missense_Mutation	novel	R2485L	0.17
SKCM	chr8	102311853	Missense_Mutation	rs778419766	R767Q	0.3
SKCM	chr8	102295522	Missense_Mutation	NA	L1275F	0.34
SKCM	chr8	102294062	Silent	NA	T1414T	0.39
SKCM	chr8	102267043	Intron	novel		0.57
SKCM	chr8	102293720	Missense_Mutation	rs753552729	R1492C	0.3
SKCM	chr8	102293721	Silent	novel	A1491A	0.29
SKCM	chr8	102346923	Missense_Mutation	NA	P186S	0.55
SKCM	chr8	102266962	Silent	rs770782554	S2469S	0.29
SKCM	chr8	102346937	Missense_Mutation	NA	P181L	0.54
SKCM	chr8	102300049	Silent	novel	P1019P	0.26
SKCM	chr8	102286608	Frame_Shift_Ins	novel	*S1656Tfs30**	0.09
SKCM	chr8	102346370	Missense_Mutation	NA	S201F	0.14
SKCM	chr8	102257675	Nonsense_Mutation	NA	W2715*	0.52
SKCM	chr8	102295779	Silent	NA	L1223L	0.11
SKCM	chr8	102279148	Missense_Mutation	NA	P2021L	0.16
SKCM	chr8	102305164	Missense_Mutation	NA	C916W	0.16
SKCM	chr8	102299472	Missense_Mutation	NA	P1061L	0.29
SKCM	chr8	102299473	Missense_Mutation	NA	P1061S	0.28
SKCM	chr8	102299454	Missense_Mutation	novel	P1067L	0.37
SKCM	chr8	102327753	Silent	novel	S490S	0.34
SKCM	chr8	102285590	Missense_Mutation	NA	P1803S	0.9
SKCM	chr8	102342572	Silent	NA	G333G	0.28
SKCM	chr8	102298933	Nonsense_Mutation	NA	R1081*	0.27
SKCM	chr8	102313851	Missense_Mutation	NA	R654W	0.17
SKCM	chr8	102258987	Missense_Mutation	NA	S2700L	0.22
SKCM	chr8	102267017	Intron	novel		0.12
SKCM	chr8	102254453	Missense_Mutation	NA	P2750L	0.55
SKCM	chr8	102267166	Intron	novel		0.68
SKCM	chr8	102267167	Intron	novel		0.68
SKCM	chr8	102298850	Splice_Region	NA	A1108A	0.27
SKCM	chr8	102326653	Missense_Mutation	NA	P498A	0.56
SKCM	chr8	102265270	Silent	novel	N2477N	0.58
SKCM	chr8	102258987	Nonsense_Mutation	novel	S2700*	0.24
SKCM	chr8	102258988	Missense_Mutation	novel	S2700T	0.25
SKCM	chr8	102295491	Missense_Mutation	novel	R1285K	0.18
SKCM	chr8	102279094	Missense_Mutation	novel	P2039L	0.2
SKCM	chr8	102311486	Missense_Mutation	NA	I810N	0.38
SKCM	chr8	102314810	Missense_Mutation	NA	P610S	0.35
SKCM	chr8	102295511	Silent	rs139159922	F1278F	0.49
SKCM	chr8	102277171	Missense_Mutation	NA	Y2104H	0.45
SKCM	chr8	102262048	Missense_Mutation	NA	F2570C	0.34
SKCM	chr8	102345467	Missense_Mutation	novel	S272F	0.86
SKCM	chr8	102360074	Missense_Mutation	NA	L128S	0.23
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.26
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.24
STAD	chr8	102345539	Missense_Mutation	NA	L248R	0.17
STAD	chr8	102261931	Missense_Mutation	novel	E2609V	0.11
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.29
STAD	chr8	102311454	Missense_Mutation	NA	P821T	0.34
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.15
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.18
STAD	chr8	102281398	Missense_Mutation	novel	D1940N	0.19
STAD	chr8	102276977	Silent	NA	S2168S	0.14
STAD	chr8	102261918	Silent	NA	G2613G	0.12
STAD	chr8	102270159	Silent	rs140195197	I2370I	0.06
STAD	chr8	102298473	Missense_Mutation	NA	T1115P	0.22
STAD	chr8	102327774	Silent	NA	T483T	0.23
STAD	chr8	102280394	Frame_Shift_Del	novel	*S2001Cfs5**	0.07
STAD	chr8	102285166	Missense_Mutation	rs747984717	A1886V	0.14
STAD	chr8	102346255	Silent	rs768814975	S239S	0.08
STAD	chr8	102280403	Missense_Mutation	NA	T1998A	0.28
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.69
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.21
STAD	chr8	102262044	Frame_Shift_Del	NA	*F2571Lfs4**	0.35
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.46
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.37
STAD	chr8	102299519	Silent	rs548926233	P1045P	0.28
STAD	chr8	102347077	Silent	rs547851962	S134S	0.28
STAD	chr8	102257698	Silent	rs566010702	L2707L	0.48
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.28
STAD	chr8	102345398	Missense_Mutation	NA	R295Q	0.43
STAD	chr8	102281478	Missense_Mutation	novel	A1913V	0.29
STAD	chr8	102285551	Missense_Mutation	novel	A1816T	0.26
STAD	chr8	102286563	Missense_Mutation	novel	S1671L	0.23
STAD	chr8	102272692	Frame_Shift_Ins	novel	*P2271Nfs8**	0.26
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.27
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.42
STAD	chr8	102360165	Frame_Shift_Del	novel	*A98Qfs23**	0.12
STAD	chr8	102277113	Frame_Shift_Ins	novel	*E2123Gfs11**	0.11
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.27
STAD	chr8	102360642	Silent	novel	G71G	0.24
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.22
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.33
STAD	chr8	102295027	Missense_Mutation	novel	D1381E	0.18
STAD	chr8	102285678	Silent	NA	N1773N	0.12
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.36
STAD	chr8	102285740	Missense_Mutation	NA	R1753C	0.18
STAD	chr8	102295668	Silent	novel	T1260T	0.07
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.52
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.21
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.35
STAD	chr8	102285740	Missense_Mutation	NA	R1753C	0.22
STAD	chr8	102285165	Silent	rs145137858	A1886A	0.22
STAD	chr8	102285742	Nonsense_Mutation	NA	L1752*	0.39
STAD	chr8	102285674	Missense_Mutation	NA	S1775R	0.21
STAD	chr8	102275756	Silent	NA	E2194E	0.18
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.54
STAD	chr8	102311324	Missense_Mutation	NA	A864V	0.2
STAD	chr8	102312212	Missense_Mutation	rs757038576	D729N	0.19
STAD	chr8	102275758	Missense_Mutation	NA	E2194K	0.19
STAD	chr8	102293995	Frame_Shift_Ins	novel	*V1437Cfs65**	0.09
STAD	chr8	102314788	Missense_Mutation	NA	C617Y	0.07
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.27
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.47
STAD	chr8	102281385	Missense_Mutation	NA	L1944S	0.15
STAD	chr8	102285737	Missense_Mutation	NA	R1754W	0.2
STAD	chr8	102300134	Missense_Mutation	NA	M991T	0.09
STAD	chr8	102326658	Missense_Mutation	NA	V496A	0.13
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.28
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.45
STAD	chr8	102312166	Frame_Shift_Ins	novel	*T744Nfs29**	0.26
STAD	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.56
TGCT	chr8	102265150	Missense_Mutation	novel	R2517S	0.1
THCA	chr8	102272718	In_Frame_Ins	novel	N2261_H2262insDY	0.08
THCA	chr8	102259007	Frame_Shift_Del	novel	*F2693Lfs25**	0.28
THCA	chr8	102285694	Missense_Mutation	NA	A1768V	0.15
THCA	chr8	102314828	Frame_Shift_Ins	novel	*K604Pfs2**	0.11
THCA	chr8	102314829	Frame_Shift_Ins	novel	*K604Efs15**	0.11
UCEC	chr8	102313803	Splice_Site	NA	X669_splice	0.48
UCEC	chr8	102361202	Missense_Mutation	NA	P38T	0.45
UCEC	chr8	102285262	Missense_Mutation	rs773575916	R1854H	0.44
UCEC	chr8	102295455	Missense_Mutation	NA	R1297Q	0.32
UCEC	chr8	102311358	Missense_Mutation	NA	N853H	0.38
UCEC	chr8	102327799	Missense_Mutation	NA	S475Y	0.28
UCEC	chr8	102271222	Nonsense_Mutation	NA	R2333*	0.06
UCEC	chr8	102253707	3'UTR	novel		0.39
UCEC	chr8	102265263	Missense_Mutation	rs759186337	R2480C	0.21
UCEC	chr8	102271222	Nonsense_Mutation	NA	R2333*	0.3
UCEC	chr8	102272599	Missense_Mutation	novel	Q2301H	0.2
UCEC	chr8	102295772	Missense_Mutation	novel	T1226A	0.13
UCEC	chr8	102412170	Splice_Region	novel		0.23
UCEC	chr8	102265247	Missense_Mutation	NA	R2485Q	0.21
UCEC	chr8	102285245	Missense_Mutation	novel	A1860S	0.33
UCEC	chr8	102299543	Silent	novel	G1037G	0.31
UCEC	chr8	102300139	Silent	novel	R989R	0.42
UCEC	chr8	102311378	Missense_Mutation	novel	M846T	0.36
UCEC	chr8	102295313	Missense_Mutation	novel	H1317N	0.72
UCEC	chr8	102277120	Frame_Shift_Ins	NA	*E2121Rfs13**	0.32
UCEC	chr8	102312403	Missense_Mutation	rs761767500	P697L	0.09
UCEC	chr8	102267163	Intron	novel		0.29
UCEC	chr8	102267053	Intron	novel		0.57
UCEC	chr8	102286554	Missense_Mutation	novel	S1674F	0.45
UCEC	chr8	102294042	Missense_Mutation	rs765061645	A1421D	0.34
UCEC	chr8	102296901	Silent	novel	H1219H	0.46
UCEC	chr8	102298410	Missense_Mutation	novel	A1136T	0.51
UCEC	chr8	102312398	Missense_Mutation	novel	A699T	0.44
UCEC	chr8	102327771	Silent	rs61752299	C484C	0.2
UCEC	chr8	102269104	Missense_Mutation	novel	F2412C	0.39	PABP
UCEC	chr8	102253779	3'UTR	novel		0.26
UCEC	chr8	102346296	Silent	novel	R226R	0.27
UCEC	chr8	102261229	Missense_Mutation	novel	P2625S	0.39
UCEC	chr8	102300125	Missense_Mutation	rs751155901	R994H	0.43
UCEC	chr8	102342553	Missense_Mutation	novel	E340K	0.43
UCEC	chr8	102311478	Nonsense_Mutation	NA	R813*	0.48
UCEC	chr8	102287490	Missense_Mutation	NA	D1634Y	0.2
UCEC	chr8	102311366	Missense_Mutation	NA	S850Y	0.15
UCEC	chr8	102295204	Missense_Mutation	rs578173678	P1353L	0.16
UCEC	chr8	102295507	Missense_Mutation	rs747701348	V1280I	0.13
UCEC	chr8	102346982	Missense_Mutation	NA	D166G	0.6
UCEC	chr8	102271158	Missense_Mutation	rs747442774	A2354V	0.48
UCEC	chr8	102265201	Missense_Mutation	novel	D2500E	0.07
UCEC	chr8	102286432	Nonsense_Mutation	NA	Q1715*	0.23
UCEC	chr8	102298934	Silent	NA	D1080D	0.23
UCEC	chr8	102312143	Missense_Mutation	NA	D752Y	0.25
UCEC	chr8	102342551	Silent	NA	E340E	0.22
UCEC	chr8	102265263	Missense_Mutation	rs759186337	R2480C	0.18
UCEC	chr8	102286511	Silent	novel	T1688T	0.17
UCEC	chr8	102300064	Missense_Mutation	novel	Q1014H	0.32
UCEC	chr8	102311789	Silent	NA	S788S	0.21
UCEC	chr8	102345432	Missense_Mutation	rs780579895	R284C	0.68
UCEC	chr8	102278850	Silent	novel	V2088V	0.21
UCEC	chr8	102277120	Frame_Shift_Ins	NA	*E2121Rfs13**	0.41
UCEC	chr8	102286513	Missense_Mutation	novel	T1688A	0.08
UCEC	chr8	102311329	Missense_Mutation	NA	K862N	0.26
UCEC	chr8	102360117	Missense_Mutation	novel	L114I	0.41
UCEC	chr8	102254480	Missense_Mutation	novel	A2741V	0.32
UCEC	chr8	102285700	Missense_Mutation	novel	A1766V	0.28
UCEC	chr8	102345538	Silent	novel	L248L	0.16
UCEC	chr8	102288246	Silent	novel	V1578V	0.17
UCEC	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.21
UCEC	chr8	102253816	3'UTR	novel		0.56
UCEC	chr8	102258988	Missense_Mutation	novel	S2700P	0.42
UCEC	chr8	102296975	Missense_Mutation	novel	E1195Q	0.06
UCEC	chr8	102305266	Silent	novel	R882R	0.07
UCEC	chr8	102277120	Frame_Shift_Ins	NA	*E2121Rfs13**	0.18
UCEC	chr8	102277121	Frame_Shift_Del	rs763652408	*E2121Kfs28**	0.26
UCEC	chr8	102253615	3'UTR	novel		0.24
UCEC	chr8	102272760	Nonsense_Mutation	novel	R2248*	0.42
UCEC	chr8	102270117	Silent	rs777255551	S2384S	0.45
UCEC	chr8	102279153	Silent	novel	N2019N	0.23
UCEC	chr8	102287501	Missense_Mutation	novel	H1630R	0.42
UCEC	chr8	102299541	Missense_Mutation	novel	D1038G	0.38
UCEC	chr8	102305219	Missense_Mutation	novel	A898V	0.4
UCEC	chr8	102253691	3'UTR	novel		0.68
UCEC	chr8	102254031	3'UTR	novel		0.56
UCEC	chr8	102265263	Missense_Mutation	rs759186337	R2480C	0.58
UCEC	chr8	102276978	Missense_Mutation	novel	S2168Y	0.11
UCEC	chr8	102277173	Missense_Mutation	novel	S2103Y	0.31
UCEC	chr8	102294993	Missense_Mutation	novel	A1393S	0.77
UCEC	chr8	102326608	Missense_Mutation	novel	N513H	0.64
UCEC	chr8	102289483	Missense_Mutation	NA	Q1561H	0.43
UCEC	chr8	102265211	Frame_Shift_Del	novel	*D2497Vfs30**	0.06
UCEC	chr8	102277167	Missense_Mutation	novel	A2105V	0.32
UCEC	chr8	102361198	Frame_Shift_Del	novel	*P39Lfs2**	0.74
UCEC	chr8	102254250	3'UTR	novel		0.46
UCEC	chr8	102329305	Missense_Mutation	NA	S398F	0.12
UCEC	chr8	102295721	Missense_Mutation	novel	L1243F	0.3
UCEC	chr8	102253223	3'UTR	novel		0.33
UCEC	chr8	102295523	Silent	rs368831957	H1274H	0.29
UCEC	chr8	102342499	In_Frame_Del	rs776412815	G357del	0.25
UCEC	chr8	102281398	Missense_Mutation	novel	D1940H	0.11
UCEC	chr8	102288242	Nonsense_Mutation	novel	*G1580Kfs4**	0.04
UCEC	chr8	102253705	3'UTR	novel		0.36
UCEC	chr8	102254248	3'UTR	novel		0.32
UCEC	chr8	102265141	Missense_Mutation	novel	K2520N	0.31
UCEC	chr8	102269029	Missense_Mutation	novel	S2437Y	0.16	PABP
UCEC	chr8	102313851	Missense_Mutation	NA	R654W	0.14
UCEC	chr8	102268979	Missense_Mutation	rs143124130	R2454W	0.34
UCEC	chr8	102293980	Missense_Mutation	novel	E1442K	0.27
UCEC	chr8	102299519	Frame_Shift_Del	novel	*A1046Lfs30**	0.09
UCEC	chr8	102253878	3'UTR	novel		0.46
UCEC	chr8	102254310	Missense_Mutation	novel	F2798V	0.29
UCEC	chr8	102286528	Missense_Mutation	rs536321614	D1683N	0.36
UCEC	chr8	102295035	Missense_Mutation	rs762276992	R1379W	0.23
UCEC	chr8	102361622	Missense_Mutation	NA	R23G	0.45
UCEC	chr8	102253861	3'UTR	novel		0.57
UCEC	chr8	102265156	Silent	novel	T2515T	0.51
UCEC	chr8	102272740	Silent	novel	Q2254Q	0.38
UCEC	chr8	102254027	3'UTR	novel		0.33
UCEC	chr8	102281454	Missense_Mutation	novel	A1921D	0.36
UCEC	chr8	102304068	Missense_Mutation	rs767143872	R977W	0.44
UCEC	chr8	102360117	Missense_Mutation	novel	L114I	0.4
UCEC	chr8	102346353	Nonsense_Mutation	NA	R207*	0.31
UCEC	chr8	102286455	Missense_Mutation	NA	A1707D	0.42
UCEC	chr8	102312166	Frame_Shift_Ins	novel	*T744Nfs29**	0.42
UCEC	chr8	102289503	Missense_Mutation	novel	R1555W	0.05
UCEC	chr8	102313822	Missense_Mutation	NA	K663N	0.25
UCEC	chr8	102254121	3'UTR	novel		0.4
UCEC	chr8	102254388	Missense_Mutation	novel	L2772F	0.19
UCEC	chr8	102297514	Missense_Mutation	novel	L1173V	0.2
UCEC	chr8	102323416	Missense_Mutation	novel	V560A	0.14
UCEC	chr8	102361198	Frame_Shift_Del	novel	*P39Lfs2**	0.36
UCEC	chr8	102298972	Splice_Site	novel	X1068_splice	0.15
UCEC	chr8	102347007	Missense_Mutation	novel	T158A	0.22
UCEC	chr8	102272628	Missense_Mutation	novel	A2292S	0.07
UCEC	chr8	102272629	In_Frame_Ins	novel	V2291_A2292insFI	0.07
UCEC	chr8	102253666	3'UTR	novel		0.48
UCEC	chr8	102298851	Missense_Mutation	novel	A1108V	0.21
UCEC	chr8	102298457	Missense_Mutation	novel	A1120V	0.07
UCEC	chr8	102277036	Frame_Shift_Ins	novel	*K2149Lfs6**	0.02
UCEC	chr8	102277037	Frame_Shift_Ins	novel	*L2148Ffs5**	0.03
UCEC	chr8	102254012	3'UTR	rs14674		0.31
UCEC	chr8	102265167	Nonsense_Mutation	novel	G2512*	0.41
UCEC	chr8	102295449	Frame_Shift_Del	NA	*R1299Gfs4**	0.26
UCEC	chr8	102361198	Frame_Shift_Del	novel	*P39Lfs2**	0.04
UCEC	chr8	102323338	Missense_Mutation	novel	E586G	0.06
UCEC	chr8	102254150	3'UTR	novel		0.23
UCEC	chr8	102272574	Missense_Mutation	NA	P2310S	0.24
UCEC	chr8	102311366	Missense_Mutation	NA	S850Y	0.16
UCEC	chr8	102312341	Splice_Site	novel	X717_splice	0.31
UCEC	chr8	102280463	Nonsense_Mutation	NA	R1978*	0.21
UCEC	chr8	102281295	Missense_Mutation	rs748421183	R1974H	0.28
UCEC	chr8	102287476	Silent	novel	G1638G	0.16
UCEC	chr8	102296968	Missense_Mutation	rs748469481	R1197Q	0.25
UCEC	chr8	102360069	Splice_Site	novel	X129_splice	0.22
UCEC	chr8	102261992	Missense_Mutation	novel	S2589A	0.42
UCEC	chr8	102253666	3'UTR	novel		0.62
UCEC	chr8	102270106	Missense_Mutation	novel	E2388G	0.48	PABP
UCEC	chr8	102305273	Missense_Mutation	novel	I880T	0.29
UCEC	chr8	102253877	3'UTR	novel		0.54
UCEC	chr8	102297497	Silent	novel	T1178T	0.3
UCEC	chr8	102296932	Missense_Mutation	rs764816360	T1209M	0.28
UCEC	chr8	102314835	Missense_Mutation	novel	E601D	0.17
UCEC	chr8	102254198	3'UTR	novel		0.31
UCEC	chr8	102253995	3'UTR	novel		0.48
UCEC	chr8	102270122	Missense_Mutation	novel	P2383S	0.58
UCEC	chr8	102281399	Frame_Shift_Ins	novel	*L1939Ffs21**	0.38
UCEC	chr8	102289503	Missense_Mutation	novel	R1555W	0.15
UCEC	chr8	102311478	Nonsense_Mutation	NA	R813*	0.33
UCEC	chr8	102272760	Nonsense_Mutation	novel	R2248*	0.4
UCEC	chr8	102293784	Silent	rs770982917	Y1470Y	0.35
UCEC	chr8	102295271	Missense_Mutation	NA	R1331C	0.27
UCEC	chr8	102300048	Missense_Mutation	novel	P1020T	0.29
UCEC	chr8	102314816	Missense_Mutation	novel	G608S	0.42
UCS	chr8	102286452	Missense_Mutation	novel	A1708V	0.47
UVM	chr8	102277085	Silent	rs777572603	T2132T	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.1061	0.15559
PRAD	AMP	0.2663	3.7005e-05
SARC	AMP	0.2763	0.18425
TGCT	AMP	0.6467	0.13696
THCA	DEL	0.01	0.038162

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0053	Kaplan-Meier Survival Analysis
SARC	0.02	Kaplan-Meier Survival Analysis
ACC	0.027	Kaplan-Meier Survival Analysis
BRCA	0.0027	Kaplan-Meier Survival Analysis
KIRP	0.017	Kaplan-Meier Survival Analysis
PAAD	0.038	Kaplan-Meier Survival Analysis
CESC	0.031	Kaplan-Meier Survival Analysis
READ	0.018	Kaplan-Meier Survival Analysis
KICH	0.01	Kaplan-Meier Survival Analysis
UCEC	0.011	Kaplan-Meier Survival Analysis
GBM	0.047	Kaplan-Meier Survival Analysis
LIHC	0.0012	Kaplan-Meier Survival Analysis
UVM	0.0027	Kaplan-Meier Survival Analysis
OV	0.027	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000104517 (Gene tree)
Gene ID: 51366
Gene Symbol: UBR5
Alias: DD5|HYD|EDD|KIAA0896|EDD1
Full Name: ubiquitin protein ligase E3 component n-recognin 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 160,569 bases
Position: chr8:102,252,273-102,412,841
Accession: 16806
RBP type: canonical RBP
Summary: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000428693	PABP	PF00658.18	4.7e-20	1	1
ENSP00000429084	PABP	PF00658.18	3.8e-19	1	1
ENSP00000220959	PABP	PF00658.18	3.8e-19	1	1
ENSP00000427819	PABP	PF00658.18	3.8e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000520539	UBR5-207	10297	XM_005250962	ENSP00000429084	2799 (aa)	XP_005251019	O95071
ENST00000520898	UBR5-208	582	-	ENSP00000429127	194 (aa)	-	H0YBB4
ENST00000521312	UBR5-209	560	-	-	- (aa)	-	-
ENST00000521922	UBR5-212	9008	XM_011517106	ENSP00000427819	2792 (aa)	XP_011515408	E7EMW7
ENST00000518205	UBR5-204	1931	-	ENSP00000428693	527 (aa)	-	E7ET84
ENST00000517465	UBR5-202	1095	-	-	- (aa)	-	-
ENST00000521566	UBR5-210	563	-	ENSP00000428062	166 (aa)	-	E5RFK7
ENST00000518145	UBR5-203	598	-	-	- (aa)	-	-
ENST00000521767	UBR5-211	1763	-	-	- (aa)	-	-
ENST00000519528	UBR5-206	325	-	-	- (aa)	-	-
ENST00000220959	UBR5-201	9418	XM_011517105	ENSP00000220959	2798 (aa)	XP_011515407	O95071
ENST00000522327	UBR5-213	701	-	-	- (aa)	-	-
ENST00000519365	UBR5-205	602	-	ENSP00000428138	201 (aa)	-	H0YAV7

Gene Model

Click here to download ENSG00000104517's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04120	Ubiquitin mediated proteolysis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000104517	Cholesterol, LDL	4.06432921751035E-11	17903299
ENSG00000104517	Personality Inventory	5.105e-005	-
ENSG00000104517	Personality Inventory	3.884e-005	-
ENSG00000104517	Myoglobin	1.2600000E-005	-
ENSG00000104517	Gestational Age	4E-6	27490719
ENSG00000104517	Live Birth	4E-6	27490719
ENSG00000104517	Diabetes Mellitus, Type 2	2E-6	28060188

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000104517	rs7840202	8	102296172	C	Gestational age at birth in labor-initiated deliveries (child effect)	27490719			EFO_0005112\|EFO_0006921
ENSG00000104517	rs4734619	8	102377272	C	Self-reported math ability	30038396	[0.009-0.018] unit decrease	0.0135	EFO_0004875
ENSG00000104517	rs10088255	8	102355371	A	Self-reported math ability (MTAG)	30038396	[0.0063-0.0133] unit decrease	0.0098	EFO_0004875
ENSG00000104517	rs7840202	8	102296172	C	Rate of cognitive decline in mild cognitive impairment (time interaction)	22833209			HP_0100543\|EFO_0007710\|EFO_0008336
ENSG00000104517	rs7827839	8	102341502	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104517's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000104517	UBR5	100	87.831	ENSAPOG00000007770	ubr5	100	88.042	Acanthochromis_polyacanthus
ENSG00000104517	UBR5	100	99.431	ENSAMEG00000014808	UBR5	100	98.927	Ailuropoda_melanoleuca
ENSG00000104517	UBR5	100	88.636	ENSACIG00000003786	ubr5	100	88.767	Amphilophus_citrinellus
ENSG00000104517	UBR5	74	88.491	ENSAOCG00000010576	-	100	88.776	Amphiprion_oce

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.