EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr8	30689258	Missense_Mutation	novel	G315D	0.5
BLCA	chr8	30696398	Silent	rs756689722	L259L	0.38
BLCA	chr8	30679652	Missense_Mutation	NA	M479I	0.07
BLCA	chr8	30703106	Silent	NA	E209E	0.25
BLCA	chr8	30700129	Missense_Mutation	NA	S216N	0.49
BRCA	chr8	30679512	3'UTR	novel		0.15
BRCA	chr8	30700128	Silent	NA	S216S	0.13
BRCA	chr8	30696398	Silent	NA	L259L	0.27
BRCA	chr8	30681956	Frame_Shift_Del	NA	*P420Lfs18**	0.2
BRCA	chr8	30696442	Nonsense_Mutation	NA	E245*	0.15
CESC	chr8	30682029	Nonsense_Mutation	NA	R396*	0.49
CESC	chr8	30700128	Silent	NA	S216S	0.3
CESC	chr8	30681991	Silent	novel	Y408Y	0.49
CESC	chr8	30680969	Missense_Mutation	novel	H452N	0.31
CESC	chr8	30696431	Silent	novel	G248G	0.35
COAD	chr8	30679461	3'UTR	novel		0.32
COAD	chr8	30681956	Frame_Shift_Del	NA	*P420Lfs18**	0.58
COAD	chr8	30689176	Silent	rs776555712	L342L	0.33
COAD	chr8	30712062	Frame_Shift_Ins	NA	*V112Gfs10**	0.43
COAD	chr8	30679480	3'UTR	rs369230085		0.24
COAD	chr8	30689163	Splice_Region	NA	L347L	0.09
COAD	chr8	30684160	Missense_Mutation	rs779830894	E361K	0.31
COAD	chr8	30680907	Missense_Mutation	NA	E472D	0.35
COAD	chr8	30684166	Missense_Mutation	rs138721223	V359I	0.29
COAD	chr8	30703126	Missense_Mutation	rs758849140	M203V	0.35
ESCA	chr8	30689303	Frame_Shift_Del	novel	*K300Rfs21**	0.79
GBM	chr8	30693004	Missense_Mutation	novel	E283K	0.1
GBM	chr8	30679525	Missense_Mutation	NA	R522C	0.26
HNSC	chr8	30700128	Silent	NA	S216S	0.82
HNSC	chr8	30689287	Silent	novel	L305L	0.49
KIRC	chr8	30680956	Missense_Mutation	NA	K456R	0.36
KIRP	chr8	30679549	Missense_Mutation	novel	S514P	0.38
LIHC	chr8	30681963	Missense_Mutation	novel	H418Y	0.23
LUAD	chr8	30703128	Missense_Mutation	NA	G202V	0.29
LUAD	chr8	30709888	Silent	NA	T116T	0.24
LUAD	chr8	30681933	Missense_Mutation	NA	E428Q	0.14
LUAD	chr8	30679612	Missense_Mutation	NA	V493L	0.41
LUAD	chr8	30693049	Nonsense_Mutation	novel	R268*	0.25
LUAD	chr8	30679642	Missense_Mutation	NA	G483W	0.3
LUAD	chr8	30703205	Silent	NA	F176F	0.18
LUSC	chr8	30693002	Missense_Mutation	novel	E283D	0.33
LUSC	chr8	30682020	Missense_Mutation	NA	E399Q	0.64
LUSC	chr8	30709820	Missense_Mutation	NA	N139S	0.69
LUSC	chr8	30689262	Missense_Mutation	NA	P314S	0.21
LUSC	chr8	30700113	Silent	rs748916113	S221S	0.19
LUSC	chr8	30681977	Missense_Mutation	NA	T413I	0.2
OV	chr8	30679452	3'UTR	novel		0.17
OV	chr8	30680901	Splice_Region	novel		0.33
OV	chr8	30693055	Missense_Mutation	NA	V266L	0.16
PRAD	chr8	30696391	Missense_Mutation	rs140665617	R262W	0.47
SARC	chr8	30689197	Silent	novel	R335R	0.36
SKCM	chr8	30680978	Missense_Mutation	NA	P449S	0.07
SKCM	chr8	30703205	Silent	NA	F176F	0.31
SKCM	chr8	30703115	Silent	NA	T206T	0.42
SKCM	chr8	30689294	Missense_Mutation	novel	S303W	0.25
SKCM	chr8	30692990	Silent	NA	V287V	0.57
SKCM	chr8	30703223	Silent	novel	I170I	0.06
SKCM	chr8	30679619	Silent	NA	G490G	0.16
SKCM	chr8	30681011	Missense_Mutation	NA	E438K	0.15
STAD	chr8	30684144	Missense_Mutation	rs142840135	N366S	0.25
STAD	chr8	30693051	Missense_Mutation	NA	L267H	0.07
STAD	chr8	30689199	Missense_Mutation	rs767042164	R335W	0.43
STAD	chr8	30682028	Missense_Mutation	rs754732491	R396Q	0.22
STAD	chr8	30679490	3'UTR	novel		0.3
STAD	chr8	30682033	Silent	novel	A394A	0.2
STAD	chr8	30684143	Silent	rs138286932	N366N	0.18
STAD	chr8	30703174	Missense_Mutation	NA	S187G	0.2
STAD	chr8	30708125	Missense_Mutation	rs150594097	R147W	0.09
TGCT	chr8	30703155	Missense_Mutation	novel	A193V	0.29
UCEC	chr8	30696473	Silent	rs140455984	S234S	0.36
UCEC	chr8	30679443	3'UTR	novel		0.4
UCEC	chr8	30684143	Silent	rs138286932	N366N	0.12
UCEC	chr8	30708101	Missense_Mutation	novel	N155H	0.2
UCEC	chr8	30679481	3'UTR	novel		0.45
UCEC	chr8	30689247	Missense_Mutation	novel	V319F	0.22
UCEC	chr8	30689215	Silent	novel	L329L	0.49
UCEC	chr8	30696447	Missense_Mutation	novel	A243V	0.18
UCEC	chr8	30680956	Missense_Mutation	novel	K456T	0.31
UCEC	chr8	30684166	Missense_Mutation	rs138721223	V359I	0.41
UCEC	chr8	30703173	Missense_Mutation	NA	S187N	0.53
UCEC	chr8	30703231	Nonsense_Mutation	novel	E168*	0.29
UCEC	chr8	30679520	Nonstop_Mutation	novel	523Cext13	0.17
UCEC	chr8	30681958	Silent	novel	P419P	0.37
UCEC	chr8	30712063	Frame_Shift_Del	novel	*K111Rfs2**	0.47
UCEC	chr8	30709884	Missense_Mutation	novel	V118L	0.46
UCEC	chr8	30680934	Missense_Mutation	novel	M463I	0.11
UCEC	chr8	30700100	Frame_Shift_Ins	novel	*Q226Sfs31**	0.45
UCEC	chr8	30679505	3'UTR	rs779495845		0.34
UCEC	chr8	30712063	Frame_Shift_Del	novel	*K111Rfs2**	0.42
UCEC	chr8	30681035	Nonsense_Mutation	NA	E430*	0.41
UCEC	chr8	30681964	Silent	novel	S417S	0.05
UCEC	chr8	30682045	Silent	novel	G390G	0.41
UCEC	chr8	30708106	Missense_Mutation	rs753098957	R153H	0.43
UCEC	chr8	30709882	Silent	rs374468714	V118V	0.69
UCEC	chr8	30689198	Missense_Mutation	rs754741581	R335Q	0.5
UCEC	chr8	30680966	Missense_Mutation	rs148353562	A453T	0.4
UCEC	chr8	30684187	Missense_Mutation	rs144097786	D352N	0.36
UCEC	chr8	30700088	Missense_Mutation	NA	L230V	0.47
UCEC	chr8	30709815	Missense_Mutation	rs142875796	R141C	0.18
UCEC	chr8	30681933	Frame_Shift_Del	novel	*E428Kfs10**	0.14
UCEC	chr8	30689184	Missense_Mutation	novel	K340E	0.15
UCEC	chr8	30679499	3'UTR	rs763647057		0.4
UCEC	chr8	30679373	3'UTR	novel		0.38
UCEC	chr8	30682029	Nonsense_Mutation	NA	R396*	0.16
UCEC	chr8	30679416	3'UTR	novel		0.42
UCEC	chr8	30684157	Missense_Mutation	NA	F362I	0.27
UCEC	chr8	30696472	Missense_Mutation	rs756475234	V235I	0.28
UCEC	chr8	30684160	Nonsense_Mutation	novel	E361*	0.44
UCEC	chr8	30684188	Silent	rs561348625	T351T	0.33
UCS	chr8	30681955	Frame_Shift_Ins	novel	*I421Yfs10**	0.19
UCS	chr8	30703208	Silent	novel	A175A	0.06
UCS	chr8	30679473	3'UTR	novel		0.59
UVM	chr8	30684166	Missense_Mutation	rs138721223	V359I	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.5368	4.5185e-08
DLBC	DEL	0.1875	0.15679
ESCA	DEL	0.3804	0.060925
PAAD	DEL	0.2174	0.050455
READ	DEL	0.5394	0.20625

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.016	Kaplan-Meier Survival Analysis
STAD	0.011	Kaplan-Meier Survival Analysis
ACC	0.044	Kaplan-Meier Survival Analysis
SKCM	0.036	Kaplan-Meier Survival Analysis
PRAD	0.011	Kaplan-Meier Survival Analysis
KIRP	0.025	Kaplan-Meier Survival Analysis
COAD	0.00022	Kaplan-Meier Survival Analysis
CESC	0.0014	Kaplan-Meier Survival Analysis
KICH	0.014	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000104687 (Gene tree)
Gene ID: 2936
Gene Symbol: GSR
Alias: N
Full Name: glutathione-disulfide reductase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 49,939 bases
Position: chr8:30,678,061-30,727,999
Accession: 4623
RBP type: non-canonical RBP
Summary: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000221130	GSR-201	3192	-	ENSP00000221130	522 (aa)	-	P00390
ENST00000537535	GSR-204	1323	-	ENSP00000438845	440 (aa)	-	P00390
ENST00000643653	GSR-208	2804	-	ENSP00000494854	123 (aa)	-	A0A2R8YF59
ENST00000541648	GSR-205	1410	-	ENSP00000444559	469 (aa)	-	P00390
ENST00000643525	GSR-207	1802	-	-	- (aa)	-	-
ENST00000546342	GSR-206	1482	-	ENSP00000445516	493 (aa)	-	P00390
ENST00000521479	GSR-202	582	-	-	- (aa)	-	-
ENST00000523295	GSR-203	913	-	ENSP00000431044	131 (aa)	-	H0YC68

Gene Model

Click here to download ENSG00000104687's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00480	Glutathione metabolism	KEGG
hsa04918	Thyroid hormone synthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000104687	Arteries	1.5140000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104687's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000104687	GSR	85	56.410	YPL091W	GLR1	95	50.740	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004362	glutathione-disulfide reductase activity	21873635.	IBA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006749	glutathione metabolic process	21873635.	IBA	Process
GO:0009055	electron transfer activity	947404.	TAS	Function
GO:0009897	external side of plasma membrane	-	IEA	Component
GO:0015949	nucleobase-containing small molecule interconversion	-	TAS	Process
GO:0022900	electron transport chain	-	IEA	Process
GO:0034599	cellular response to oxidative stress	21873635.	IBA	Process
GO:0034599	cellular response to oxidative stress	-	TAS	Process
GO:0045454	cell redox homeostasis	21873635.	IBA	Process
GO:0050660	flavin adenine dinucleotide binding	21873635.	IBA	Function
GO:0050661	NADP binding	-	IEA	Function
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:0098869	cellular oxidant detoxification	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.