EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	45939899	Missense_Mutation	novel	Q481H	0.26
BLCA	chr19	45940937	Silent	novel	L135L	0.3
BLCA	chr19	45940016	Silent	rs748017043	I442I	0.42
BLCA	chr19	45940876	Missense_Mutation	rs200399286	V156M	0.27
BLCA	chr19	45940010	Silent	NA	K444K	0.34
BLCA	chr19	45940168	Missense_Mutation	novel	G392R	0.42
BRCA	chr19	45961031	Missense_Mutation	NA	K70E	0.3
BRCA	chr19	45953865	Missense_Mutation	NA	R104Q	0.56
CESC	chr19	45940832	Silent	rs772334065	P170P	0.19
COAD	chr19	45940423	Missense_Mutation	novel	G307S	0.29
COAD	chr19	45939979	Missense_Mutation	novel	R455W	0.17	KH_1
COAD	chr19	45953890	Missense_Mutation	novel	H96N	0.04
COAD	chr19	45940412	Silent	novel	A310A	0.42
COAD	chr19	45939985	Missense_Mutation	NA	R453W	0.35	KH_1
COAD	chr19	45940892	Silent	NA	G150G	0.55
COAD	chr19	45940919	Silent	rs368021609	T141T	0.61
COAD	chr19	45940876	Missense_Mutation	rs200399286	V156M	0.37
COAD	chr19	45961074	Silent	NA	I55I	0.11
COAD	chr19	45961110	Silent	novel	A43A	0.38
ESCA	chr19	45940766	Frame_Shift_Del	novel	E187*	0.11
ESCA	chr19	45940712	Silent	novel	L210L	0.37
ESCA	chr19	45961052	Missense_Mutation	novel	G63R	0.57
GBM	chr19	45940113	Missense_Mutation	novel	E410G	0.38	KH_1
HNSC	chr19	45940054	Missense_Mutation	novel	V430M	0.25	KH_1
HNSC	chr19	45940904	Silent	novel	I146I	0.14
HNSC	chr19	45940784	Silent	NA	P186P	0.08
HNSC	chr19	45953935	Missense_Mutation	NA	R81W	0.28
KIRP	chr19	45940449	Frame_Shift_Ins	novel	*L298Pfs106**	0.5
KIRP	chr19	45940477	Missense_Mutation	NA	Y289H	0.17
LAML	chr19	45953843	Silent	novel	T111T	0.73
LIHC	chr19	45953935	Missense_Mutation	NA	R81W	0.31
LIHC	chr19	45953783	Missense_Mutation	NA	K131N	0.38
LUAD	chr19	45940627	Missense_Mutation	novel	P239T	0.35
LUAD	chr19	45940729	Frame_Shift_Del	novel	*Q205Rfs191**	0.14
LUAD	chr19	45940150	Missense_Mutation	NA	E398Q	0.11
LUSC	chr19	45940106	Silent	novel	A412A	0.21
LUSC	chr19	45973335	Missense_Mutation	NA	P6R	0.43
LUSC	chr19	45973336	Missense_Mutation	NA	P6T	0.4
LUSC	chr19	45953803	Missense_Mutation	novel	M125V	0.35
LUSC	chr19	45940052	Silent	NA	V430V	0.38
LUSC	chr19	45940744	Missense_Mutation	novel	V200L	0.07
OV	chr19	45940091	Silent	NA	L417L	0.23
OV	chr19	45953793	Missense_Mutation	novel	D128G	0.11
PAAD	chr19	45939887	Silent	novel	A485A	0.19
PRAD	chr19	45953806	Missense_Mutation	NA	T124S	0.3
PRAD	chr19	45940027	Missense_Mutation	NA	R439C	0.09	KH_1
PRAD	chr19	45940694	Silent	novel	N216N	0.1
READ	chr19	45940693	Missense_Mutation	rs754714738	V217M	0.58
READ	chr19	45940733	Missense_Mutation	NA	D203E	0.42
READ	chr19	45939953	Silent	novel	P463P	0.41
READ	chr19	45940754	Silent	novel	I196I	0.25
READ	chr19	45939953	Silent	novel	P463P	0.6
SKCM	chr19	45961149	Missense_Mutation	novel	E30D	0.27
SKCM	chr19	45940693	Missense_Mutation	rs754714738	V217M	0.55
SKCM	chr19	45940787	Silent	novel	E185E	0.48
SKCM	chr19	45940169	Silent	NA	A391A	0.28
SKCM	chr19	45940794	Missense_Mutation	novel	S183N	0.19
SKCM	chr19	45940666	Missense_Mutation	NA	P226S	0.37
SKCM	chr19	45939911	Silent	NA	V477V	0.45
SKCM	chr19	45939779	3'UTR	novel		0.33
SKCM	chr19	45940873	Missense_Mutation	NA	M157V	0.38
STAD	chr19	45940064	Frame_Shift_Ins	novel	*K427Qfs99**	0.25	KH_1
STAD	chr19	45940648	Missense_Mutation	NA	A232T	0.28
STAD	chr19	45939987	Missense_Mutation	NA	T452M	0.18	KH_1
UCEC	chr19	45939888	Missense_Mutation	novel	A485V	0.13
UCEC	chr19	45940018	Missense_Mutation	novel	I442V	0.15	KH_1
UCEC	chr19	45940004	Silent	NA	G446G	0.33
UCEC	chr19	45953876	Silent	rs761319971	A100A	0.21
UCEC	chr19	45953935	Missense_Mutation	NA	R81W	0.37
UCEC	chr19	45953913	Missense_Mutation	rs781569043	T88M	0.43
UCEC	chr19	45939793	3'UTR	novel		0.38
UCEC	chr19	45939980	Silent	novel	N454N	0.19
UCEC	chr19	45953787	Missense_Mutation	novel	A130V	0.06
UCEC	chr19	45953850	Missense_Mutation	rs771796947	A109V	0.12
UCEC	chr19	45953797	Missense_Mutation	NA	P127T	0.33
UCEC	chr19	45961011	Splice_Region	rs139055477	P76P	0.09
UCEC	chr19	45953870	Silent	NA	K102K	0.28
UCEC	chr19	45961022	Missense_Mutation	novel	D73Y	0.22
UCEC	chr19	45939839	3'UTR	novel		0.28
UCEC	chr19	45939945	Missense_Mutation	rs757517954	T466M	0.07	KH_1
UCEC	chr19	45940031	Silent	NA	G437G	0.38
UCS	chr19	45940031	Silent	novel	G437G	0.2

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0814	0.027508
KIRP	DEL	0.0486	0.054726
OV	DEL	0.468	2.441e-17
READ	DEL	0.0727	0.23023
TGCT	DEL	0.2867	0.0046229
UCS	DEL	0.1964	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.03	Kaplan-Meier Survival Analysis
SARC	0.041	Kaplan-Meier Survival Analysis
MESO	0.00028	Kaplan-Meier Survival Analysis
ACC	0.0039	Kaplan-Meier Survival Analysis
UCS	0.022	Kaplan-Meier Survival Analysis
LUSC	0.014	Kaplan-Meier Survival Analysis
KIRP	0.00033	Kaplan-Meier Survival Analysis
COAD	0.038	Kaplan-Meier Survival Analysis
PAAD	0.00013	Kaplan-Meier Survival Analysis
LAML	0.00069	Kaplan-Meier Survival Analysis
KICH	0.018	Kaplan-Meier Survival Analysis
LGG	0.01	Kaplan-Meier Survival Analysis
OV	0.005	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000104967 (Gene tree)
Gene ID: 4858
Gene Symbol: NOVA2
Alias: ANOVA|NOVA3
Full Name: NOVA alternative splicing regulator 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 39,813 bases
Position: chr19:45,933,734-45,973,546
Accession: 7887
RBP type: canonical RBP
Summary: (NOVA Alternative Splicing Regulator 2) is a Protein Coding gene. Diseases associated with NOVA2 include Fragile X Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is NOVA1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000263257	KH_1	PF00013.29	9.4e-47	1	3
ENSP00000263257	KH_1	PF00013.29	9.4e-47	2	3
ENSP00000263257	KH_1	PF00013.29	9.4e-47	3	3

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9789075	The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia.	Proc Natl Acad Sci U S A	1998 Oct 27	Yang YY	-
10368286	Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains.	Structure	1999 Feb 15	Lewis HA	-
11784037	pasilla, the Drosophila homologue of the human Nova-1 and Nova-2 proteins, is required for normal secretion in the salivary gland.	Dev Biol	2001 Nov 15	Seshaiah P	-
16213216	Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition.	Cell	2005 Oct 7	Huang CS	-
21150296	The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels.	Channels (Austin)	2010 Nov-Dec	Allen SE	-
20620865	Alternative splicing disabled by Nova2.	Neuron	2010 Jun 24	Park TJ	doi: 10.1016/j.neuron.2010.06.012.
20620871	Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling.	Neuron	2010 Jun 24	Yano M	doi: 10.1016/j.neuron.2010.05.007.
24658850	RNA-binding proteins in neurological diseases.	Sci China Life Sci	2014 Apr	Zhou H	-
27223325	NOVA2-mediated RNA regulation is required for axonal pathfinding during development.	Elife	2016 May 25	Saito Y	doi: 10.7554/eLife.14371.
25921069	Global Promotion of Alternative Internal Exon Usage by mRNA 3' End Formation Factors.	Mol Cell	2015 Jun 4	Misra A	doi: 10.1016/j.molcel.2015.03.016
28910620	cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation.	Neuron	2017 Sep 13	Hwang HW	doi: 10.1016/j.neuron.2017.08.024.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000263257	NOVA2-201	7803	-	ENSP00000263257	492 (aa)	-	Q9UNW9
ENST00000599462	NOVA2-203	589	-	-	- (aa)	-	-
ENST00000596784	NOVA2-202	698	XM_006723230	ENSP00000471736	40 (aa)	XP_006723293	M0R1A0

Gene Model

Click here to download ENSG00000104967's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000104967	Lipoprotein(a)	5.8240000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000104967's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000104967	NOVA2	58	41.538	ENSG00000090097	PCBP4	88	30.909
ENSG00000104967	NOVA2	50	41.096	ENSG00000197111	PCBP2	89	36.486
ENSG00000104967	NOVA2	59	40.845	ENSG00000183570	PCBP3	91	41.429
ENSG00000104967	NOVA2	51	41.558	ENSG00000169564	PCBP1	66	41.558
ENSG00000104967	NOVA2	100	77.500	ENSG00000139910	NOVA1	100	82.569
ENSG00000104967	NOVA2	54	37.681	ENSG00000165119	HNRNPK	64	38.806

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000104967	NOVA2	100	100.000	ENSAMEG00000000649	NOVA2	92	100.000	Ailuropoda_melanoleuca
ENSG00000104967	NOVA2	100	90.000	ENSACAG00000003724	NOVA2	61	89.643	Anolis_carolinensis
ENSG00000104967	NOVA2	100	100.000	ENSANAG00000022520	NOVA2	60	86.275	Aotus_nancymaae
ENSG00000104967	NOVA2	100	100.000	ENSBTAG00000013157	NOVA2	100	100.000	Bos_taurus
ENSG00000104967	NOVA2	100	100.000	ENSCJAG00000012121	NOVA2	89	100.000	Callithrix_jacchus
ENSG00000104967	NOVA2	100	100.000	ENSCAFG00000004359	NOVA2	97	95.325	Canis_familiaris
ENSG00000104967	NOVA2	100	100.000	ENSCAFG00020001763	NOVA2	67	100.000	Canis_lupus_dingo
ENSG00000104967	NOVA2	100	100.000	ENSCHIG00000010547	NOVA2	89	100.000	Capra_hircus
ENSG00000104967	NOVA2	69	100.000	ENSCPOG00000020582	NOVA2	90	100.000	Cavia_porcellus
ENSG00000104967	NOVA2	100	100.000	ENSCCAG00000037311	NOVA2	88	100.000	Cebus_capucinus
ENSG00000104967	NOVA2	100	100.000	ENSCATG00000045122	NOVA2	100	100.000	Cercocebus_atys
ENSG00000104967	NOVA2	60	99.219	ENSCLAG00000000991	-	86	99.219	Chinchilla_lanigera
ENSG00000104967	NOVA2	100	100.000	ENSCSAG00000003105	NOVA2	97	96.341	Chlorocebus_sabaeus
ENSG00000104967	NOVA2	100	92.500	ENSCPBG00000007153	NOVA2	58	90.036	Chrysemys_picta_bellii
ENSG00000104967	NOVA2	97	44.106	ENSCSAVG00000009137	-	88	61.176	Ciona_savignyi
ENSG00000104967	NOVA2	100	100.000	ENSCGRG00001013374	Nova2	91	98.377	Cricetulus_griseus_chok1gshd
ENSG00000104967	NOVA2	100	100.000	ENSDNOG00000031258	NOVA2	99	96.099	Dasypus_novemcinctus
ENSG00000104967	NOVA2	100	100.000	ENSDORG00000026568	Nova2	97	100.000	Dipodomys_ordii
ENSG00000104967	NOVA2	68	55.556	ENSEBUG00000004758	-	84	55.556	Eptatretus_burgeri
ENSG00000104967	NOVA2	95	71.053	ENSEBUG00000012405	NOVA2	78	69.286	Eptatretus_burgeri
ENSG00000104967	NOVA2	100	100.000	ENSEASG00005014236	NOVA2	99	96.319	Equus_asinus_asinus
ENSG00000104967	NOVA2	62	83.333	ENSECAG00000024041	NOVA2	88	89.634	Equus_caballus
ENSG00000104967	NOVA2	100	100.000	ENSFCAG00000024784	NOVA2	100	99.187	Felis_catus
ENSG00000104967	NOVA2	100	92.500	ENSGAGG00000009498	NOVA2	61	91.007	Gopherus_agassizii
ENSG00000104967	NOVA2	100	100.000	ENSGGOG00000000325	NOVA2	100	95.708	Gorilla_gorilla
ENSG00000104967	NOVA2	100	100.000	ENSHGLG00000016103	NOVA2	94	90.854	Heterocephalus_glaber_female
ENSG00000104967	NOVA2	100	100.000	ENSHGLG00100015153	NOVA2	100	100.000	Heterocephalus_glaber_male
ENSG00000104967	NOVA2	100	100.000	ENSSTOG00000022126	NOVA2	100	97.689	Ictidomys_tridecemlineatus
ENSG00000104967	NOVA2	100	100.000	ENSJJAG00000000944	Nova2	100	100.000	Jaculus_jaculus
ENSG00000104967	NOVA2	100	97.500	ENSLAFG00000025917	NOVA2	100	97.210	Loxodonta_africana
ENSG00000104967	NOVA2	100	100.000	ENSMFAG00000043672	NOVA2	72	100.000	Macaca_fascicularis
ENSG00000104967	NOVA2	100	100.000	ENSMMUG00000004085	NOVA2	67	100.000	Macaca_mulatta
ENSG00000104967	NOVA2	100	100.000	ENSMNEG00000040253	NOVA2	87	97.358	Macaca_nemestrina
ENSG00000104967	NOVA2	100	100.000	ENSMLEG00000030389	NOVA2	98	100.000	Mandrillus_leucophaeus
ENSG00000104967	NOVA2	100	100.000	ENSMAUG00000014038	Nova2	98	90.244	Mesocricetus_auratus
ENSG00000104967	NOVA2	100	100.000	ENSMICG00000028720	NOVA2	100	99.593	Microcebus_murinus
ENSG00000104967	NOVA2	100	100.000	ENSMOCG00000018489	Nova2	92	98.577	Microtus_ochrogaster
ENSG00000104967	NOVA2	100	92.500	ENSMODG00000021529	NOVA2	77	90.278	Monodelphis_domestica
ENSG00000104967	NOVA2	100	100.000	MGP_CAROLIEiJ_G0029261	-	100	98.488	Mus_caroli
ENSG00000104967	NOVA2	100	100.000	MGP_CAROLIEiJ_G0029262	-	100	98.488	Mus_caroli
ENSG00000104967	NOVA2	100	100.000	ENSMUSG00000030411	Nova2	100	98.577	Mus_musculus
ENSG00000104967	NOVA2	100	100.000	MGP_PahariEiJ_G0021121	-	94	98.577	Mus_pahari
ENSG00000104967	NOVA2	100	100.000	MGP_PahariEiJ_G0021122	-	100	98.577	Mus_pahari
ENSG00000104967	NOVA2	100	100.000	MGP_SPRETEiJ_G0030345	-	89	98.577	Mus_spretus
ENSG00000104967	NOVA2	100	100.000	MGP_SPRETEiJ_G0030346	-	100	98.577	Mus_spretus
ENSG00000104967	NOVA2	64	97.753	ENSMPUG00000005444	NOVA2	99	97.753	Mustela_putorius_furo
ENSG00000104967	NOVA2	100	100.000	ENSMLUG00000008039	-	100	99.425	Myotis_lucifugus
ENSG00000104967	NOVA2	100	100.000	ENSNGAG00000014104	Nova2	100	99.291	Nannospalax_galili
ENSG00000104967	NOVA2	100	100.000	ENSNLEG00000002399	-	100	88.235	Nomascus_leucogenys
ENSG00000104967	NOVA2	100	92.500	ENSMEUG00000000562	NOVA2	79	80.195	Notamacropus_eugenii
ENSG00000104967	NOVA2	62	99.038	ENSOPRG00000010051	NOVA2	68	100.000	Ochotona_princeps
ENSG00000104967	NOVA2	100	100.000	ENSODEG00000008485	NOVA2	96	90.244	Octodon_degus
ENSG00000104967	NOVA2	100	100.000	ENSOCUG00000022891	NOVA2	100	100.000	Oryctolagus_cuniculus
ENSG00000104967	NOVA2	100	100.000	ENSOGAG00000028973	NOVA2	95	99.592	Otolemur_garnettii
ENSG00000104967	NOVA2	100	100.000	ENSOARG00000010434	-	72	100.000	Ovis_aries
ENSG00000104967	NOVA2	100	100.000	ENSPPAG00000035049	-	100	100.000	Pan_paniscus
ENSG00000104967	NOVA2	100	100.000	ENSPPRG00000005941	NOVA2	96	100.000	Panthera_pardus
ENSG00000104967	NOVA2	100	100.000	ENSPTIG00000015368	NOVA2	64	100.000	Panthera_tigris_altaica
ENSG00000104967	NOVA2	100	100.000	ENSPTRG00000011173	NOVA2	100	100.000	Pan_troglodytes
ENSG00000104967	NOVA2	100	100.000	ENSPANG00000023868	NOVA2	96	100.000	Papio_anubis
ENSG00000104967	NOVA2	100	90.244	ENSPSIG00000006125	-	85	95.105	Pelodiscus_sinensis
ENSG00000104967	NOVA2	100	92.500	ENSPCIG00000007632	NOVA2	59	96.104	Phascolarctos_cinereus
ENSG00000104967	NOVA2	100	100.000	ENSPPYG00000010139	-	99	93.462	Pongo_abelii
ENSG00000104967	NOVA2	100	100.000	ENSPCOG00000022693	NOVA2	98	99.143	Propithecus_coquereli
ENSG00000104967	NOVA2	100	100.000	ENSPVAG00000006169	NOVA2	100	94.802	Pteropus_vampyrus
ENSG00000104967	NOVA2	100	100.000	ENSRNOG00000013847	Nova2	99	97.755	Rattus_norvegicus
ENSG00000104967	NOVA2	100	100.000	ENSRROG00000037399	NOVA2	76	100.000	Rhinopithecus_roxellana
ENSG00000104967	NOVA2	58	100.000	ENSSBOG00000001000	-	84	87.500	Saimiri_boliviensis_boliviensis
ENSG00000104967	NOVA2	78	92.135	ENSSPUG00000002591	NOVA2	94	88.542	Sphenodon_punctatus
ENSG00000104967	NOVA2	100	100.000	ENSSSCG00000035029	NOVA2	100	99.593	Sus_scrofa
ENSG00000104967	NOVA2	95	86.842	ENSTRUG00000019498	NOVA2	96	87.500	Takifugu_rubripes
ENSG00000104967	NOVA2	100	100.000	ENSTTRG00000001612	NOVA2	100	97.248	Tursiops_truncatus
ENSG00000104967	NOVA2	100	100.000	ENSUAMG00000015647	NOVA2	68	100.000	Ursus_americanus
ENSG00000104967	NOVA2	60	98.374	ENSVVUG00000002971	-	57	98.374	Vulpes_vulpes
ENSG00000104967	NOVA2	98	71.795	ENSXETG00000019101	nova2	87	81.443	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	IEA	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003723	RNA binding	10735272.	NAS	Function
GO:0005634	nucleus	-	IEA	Component
GO:0051252	regulation of RNA metabolic process	-	IEA	Process
GO:0120163	negative regulation of cold-induced thermogenesis	27635635.	ISS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.