EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
21567094Caspase-14 is an anti-apoptotic protein targeting apoptosis-inducing factor in lung adenocarcinomas.Oncol Rep2011 AugFang HYdoi: 10.3892/or.2011.1292
23408445Genetic variants of AICDA/CASP14 associated with childhood brain tumor.Genet Mol Res2013 Jun 20Jeon Sdoi: 10.4238/2013.January.30.1.
16061862Tumor-associated alterations in caspase-14 expression in epithelial malignancies.Clin Cancer Res2005 Aug 1Krajewska M-
25651379S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3/caspase-14 pathway in A431 cells.Exp Dermatol2015 MayLi Tdoi: 10.1111/exd.12645
28570747Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients.J Surg Oncol2017 NovHanda Tdoi: 10.1002/jso.24705
17436577Expression of caspase-14 reduces tumorigenicity of skin cancer cells.In Vivo2007 Mar-AprHsu S-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr19150522125'UTRnovel0.8
BLCAchr1915053891SilentNAL112L0.36
BLCAchr1915053917Missense_Mutationrs750059845R121Q0.28
BRCAchr19150522325'UTRnovel0.11
BRCAchr1915055211Missense_MutationNAK153E0.29
CESCchr1915053763Missense_MutationNAQ70K0.23
CESCchr1915053805Missense_Mutationrs746084490V84M0.31
CESCchr1915055531Missense_MutationnovelE208K0.41
CESCchr1915053820Missense_MutationNAH89Y0.4
COADchr1915056066Missense_Mutationrs751321912R236W0.2
COADchr1915055507Nonsense_MutationnovelG200*0.34
COADchr1915055437Silentrs765384541I176I0.09
COADchr1915053882Silentrs549293146F109F0.32
ESCAchr1915053742Missense_MutationnovelE63Q0.31
GBMchr1915053585Missense_MutationNAR44L0.21
GBMchr1915055433Missense_MutationnovelY175S0.63
GBMchr1915053757Missense_MutationnovelF68I0.09
HNSCchr1915053598Silentrs751047294F48F0.47
HNSCchr1915053615Missense_MutationnovelR54T0.19
KIRPchr1915053822SilentNAH89H0.16
LAMLchr1915055430Missense_MutationnovelG174E0.03
LGGchr1915055256Missense_Mutationrs148526551V168I0.09
LGGchr1915053951Frame_Shift_DelnovelC132Wfs*90.09
LIHCchr19150522225'UTRnovel0.08
LUADchr1915055488Frame_Shift_DelnovelD193Efs*140.09
LUADchr1915053594Missense_MutationnovelR47K0.16
LUADchr1915053585Missense_Mutationrs755436920R44Q0.22
LUADchr1915055429Splice_SiteNAX174_splice0.31
LUSCchr1915055440SilentNAA177A0.27
LUSCchr1915053911Missense_MutationnovelA119V0.09
LUSCchr1915053828Missense_MutationnovelR91S0.24
OVchr1915053879SilentnovelL108L0.05
OVchr1915053753SilentnovelE66E0.06
READchr1915052264Missense_Mutationrs77227419R5W0.46
READchr1915055994Missense_Mutationrs200139686R212W0.33
READchr1915053584Missense_Mutationrs61731993R44W0.46
READchr1915053900Missense_MutationnovelK115N0.44
SARCchr1915053788Missense_MutationnovelP78L0.43
SKCMchr1915053781Missense_MutationNAE76K0.43
SKCMchr1915055497Silentrs778384693T196T0.39
SKCMchr1915053844Missense_MutationNAG97R0.34
SKCMchr1915053844Missense_MutationNAG97R0.45
SKCMchr1915056035Silentrs773573153R225R0.36
SKCMchr1915055450Missense_MutationNAD181N0.46
SKCMchr1915056067Missense_Mutationrs147759883R236Q0.4
SKCMchr1915053632Splice_SiteNAX59_splice0.73
SKCMchr1915053617Missense_MutationnovelD55N0.79
SKCMchr1915056041Silentrs61750056T227T0.3
SKCMchr1915055155Splice_Regionnovel0.45
SKCMchr1915053572Missense_MutationNAE40K0.35
SKCMchr1915055225Missense_MutationNAQ157H0.22
SKCMchr1915053939SilentnovelI128I0.63
SKCMchr1915055459Missense_MutationnovelG184S0.27
SKCMchr1915056035Silentrs773573153R225R0.36
SKCMchr1915053804Silentrs776761326F83F0.26
SKCMchr1915053825SilentNAG90G0.06
SKCMchr1915052206Splice_Regionnovel0.26
SKCMchr1915056044SilentNAN228N0.38
SKCMchr1915055429Splice_SitenovelX174_splice0.21
SKCMchr1915055450Missense_MutationNAD181N0.11
SKCMchr1915053738Silentrs377160369F61F0.42
SKCMchr1915055521SilentNAE204E0.14
SKCMchr1915053551Missense_Mutationrs775612358E33K0.43
SKCMchr1915053522Missense_MutationNAL23R0.38
SKCMchr1915053632Splice_SiteNAX59_splice0.24
SKCMchr1915053599Missense_MutationNAE49K0.24
STADchr1915053958Missense_MutationnovelE135K0.13
STADchr1915053598Silentrs751047294F48F0.34
STADchr1915055492Missense_MutationNAF195I0.43
STADchr1915055438Missense_Mutationrs140182507A177T0.43
STADchr1915055994Missense_Mutationrs200139686R212W0.4
STADchr1915055434SilentnovelY175Y0.23
THCAchr1915055444Nonsense_Mutationrs546136139R179*0.36
UCECchr1915053584Missense_Mutationrs61731993R44W0.3
UCECchr1915053551Missense_Mutationrs775612358E33K0.42
UCECchr19150522345'UTRnovel0.29
UCECchr1915055515SilentnovelI202I0.45
UCECchr1915053742Nonsense_MutationnovelE63*0.1
UCECchr1915053911Missense_MutationnovelA119V0.21
UCECchr1915055437Silentrs765384541I176I0.46
UCECchr1915055531Nonsense_MutationnovelE208*0.26
UCECchr1915053905Missense_MutationnovelC117Y0.23
UCECchr1915056009Nonsense_MutationnovelE217*0.58
UCECchr1915053584Missense_Mutationrs61731993R44W0.5
UCECchr1915053882Silentrs549293146F109F0.5
UCECchr1915056053SilentnovelI231I0.14
UCECchr1915053551Missense_Mutationrs775612358E33K0.43
UCECchr1915055509SilentnovelG200G0.34
UCECchr1915053854Missense_MutationnovelG100V0.43
UCECchr19150522405'UTRnovel0.12
UCECchr19150522285'UTRnovel0.42
UCECchr1915053611Missense_MutationNAK53Q0.35
UCECchr1915053599Missense_MutationNAE49K0.24
UCECchr1915053882Silentrs549293146F109F0.36
UCECchr1915055445Missense_Mutationrs185297693R179Q0.24
UCECchr1915055218Missense_MutationnovelS155N0.41
UCECchr1915055256Missense_Mutationrs148526551V168I0.25
UCECchr1915052262Missense_Mutationrs201635146P4L0.31
UVMchr1915055445Missense_Mutationrs185297693R179Q0.15

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCAAMP0.16020.074592
READDEL0.07270.23023
THCADEL0.0140.090402

Survival Analysis
CancerP-value Q-value
STAD0.04

Kaplan-Meier Survival Analysis

UCS0.048

Kaplan-Meier Survival Analysis

SKCM0.00022

Kaplan-Meier Survival Analysis

BRCA0.016

Kaplan-Meier Survival Analysis

PAAD0.0014

Kaplan-Meier Survival Analysis

CESC0.02

Kaplan-Meier Survival Analysis

OV0.011

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000105141 (Gene tree)
Gene ID
23581
Gene Symbol
CASP14
Alias
MICE|MGC119078|MGC119079
Full Name
caspase 14
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
8,910 bases
Position
chr19:15,049,384-15,058,293
Accession
1502
RBP type
non-canonical RBP
Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000427043CASP14-2013241XM_011527861ENSP00000393417242 (aa)XP_011526163P31944
ENST00000598738CASP14-202771--- (aa)--
Gene Model
Click here to download ENSG00000105141's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105141's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004197cysteine-type endopeptidase activity10203698.TASFunction
GO:0005515protein binding24872419.25416956.IPIFunction
GO:0005634nucleus23377137.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm23377137.IDAComponent
GO:0005739mitochondrion-IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006508proteolysis-IEAProcess
GO:0006915apoptotic process21873635.IBAProcess
GO:0008544epidermis development10203698.TASProcess
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage21873635.IBAProcess
GO:0031424keratinization18309324.TASProcess
GO:0045095keratin filament-IEAComponent
GO:0070268cornification18309324.TASProcess
GO:0097153cysteine-type endopeptidase activity involved in apoptotic process21873635.IBAFunction
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