EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21567094	Caspase-14 is an anti-apoptotic protein targeting apoptosis-inducing factor in lung adenocarcinomas.	Oncol Rep	2011 Aug	Fang HY	doi: 10.3892/or.2011.1292
23408445	Genetic variants of AICDA/CASP14 associated with childhood brain tumor.	Genet Mol Res	2013 Jun 20	Jeon S	doi: 10.4238/2013.January.30.1.
16061862	Tumor-associated alterations in caspase-14 expression in epithelial malignancies.	Clin Cancer Res	2005 Aug 1	Krajewska M	-
25651379	S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3/caspase-14 pathway in A431 cells.	Exp Dermatol	2015 May	Li T	doi: 10.1111/exd.12645
28570747	Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients.	J Surg Oncol	2017 Nov	Handa T	doi: 10.1002/jso.24705
17436577	Expression of caspase-14 reduces tumorigenicity of skin cancer cells.	In Vivo	2007 Mar-Apr	Hsu S	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr19	15052212	5'UTR	novel		0.8
BLCA	chr19	15053891	Silent	NA	L112L	0.36
BLCA	chr19	15053917	Missense_Mutation	rs750059845	R121Q	0.28
BRCA	chr19	15052232	5'UTR	novel		0.11
BRCA	chr19	15055211	Missense_Mutation	NA	K153E	0.29
CESC	chr19	15053763	Missense_Mutation	NA	Q70K	0.23
CESC	chr19	15053805	Missense_Mutation	rs746084490	V84M	0.31
CESC	chr19	15055531	Missense_Mutation	novel	E208K	0.41
CESC	chr19	15053820	Missense_Mutation	NA	H89Y	0.4
COAD	chr19	15056066	Missense_Mutation	rs751321912	R236W	0.2
COAD	chr19	15055507	Nonsense_Mutation	novel	G200*	0.34
COAD	chr19	15055437	Silent	rs765384541	I176I	0.09
COAD	chr19	15053882	Silent	rs549293146	F109F	0.32
ESCA	chr19	15053742	Missense_Mutation	novel	E63Q	0.31
GBM	chr19	15053585	Missense_Mutation	NA	R44L	0.21
GBM	chr19	15055433	Missense_Mutation	novel	Y175S	0.63
GBM	chr19	15053757	Missense_Mutation	novel	F68I	0.09
HNSC	chr19	15053598	Silent	rs751047294	F48F	0.47
HNSC	chr19	15053615	Missense_Mutation	novel	R54T	0.19
KIRP	chr19	15053822	Silent	NA	H89H	0.16
LAML	chr19	15055430	Missense_Mutation	novel	G174E	0.03
LGG	chr19	15055256	Missense_Mutation	rs148526551	V168I	0.09
LGG	chr19	15053951	Frame_Shift_Del	novel	*C132Wfs9**	0.09
LIHC	chr19	15052222	5'UTR	novel		0.08
LUAD	chr19	15055488	Frame_Shift_Del	novel	*D193Efs14**	0.09
LUAD	chr19	15053594	Missense_Mutation	novel	R47K	0.16
LUAD	chr19	15053585	Missense_Mutation	rs755436920	R44Q	0.22
LUAD	chr19	15055429	Splice_Site	NA	X174_splice	0.31
LUSC	chr19	15055440	Silent	NA	A177A	0.27
LUSC	chr19	15053911	Missense_Mutation	novel	A119V	0.09
LUSC	chr19	15053828	Missense_Mutation	novel	R91S	0.24
OV	chr19	15053879	Silent	novel	L108L	0.05
OV	chr19	15053753	Silent	novel	E66E	0.06
READ	chr19	15052264	Missense_Mutation	rs77227419	R5W	0.46
READ	chr19	15055994	Missense_Mutation	rs200139686	R212W	0.33
READ	chr19	15053584	Missense_Mutation	rs61731993	R44W	0.46
READ	chr19	15053900	Missense_Mutation	novel	K115N	0.44
SARC	chr19	15053788	Missense_Mutation	novel	P78L	0.43
SKCM	chr19	15053781	Missense_Mutation	NA	E76K	0.43
SKCM	chr19	15055497	Silent	rs778384693	T196T	0.39
SKCM	chr19	15053844	Missense_Mutation	NA	G97R	0.34
SKCM	chr19	15053844	Missense_Mutation	NA	G97R	0.45
SKCM	chr19	15056035	Silent	rs773573153	R225R	0.36
SKCM	chr19	15055450	Missense_Mutation	NA	D181N	0.46
SKCM	chr19	15056067	Missense_Mutation	rs147759883	R236Q	0.4
SKCM	chr19	15053632	Splice_Site	NA	X59_splice	0.73
SKCM	chr19	15053617	Missense_Mutation	novel	D55N	0.79
SKCM	chr19	15056041	Silent	rs61750056	T227T	0.3
SKCM	chr19	15055155	Splice_Region	novel		0.45
SKCM	chr19	15053572	Missense_Mutation	NA	E40K	0.35
SKCM	chr19	15055225	Missense_Mutation	NA	Q157H	0.22
SKCM	chr19	15053939	Silent	novel	I128I	0.63
SKCM	chr19	15055459	Missense_Mutation	novel	G184S	0.27
SKCM	chr19	15056035	Silent	rs773573153	R225R	0.36
SKCM	chr19	15053804	Silent	rs776761326	F83F	0.26
SKCM	chr19	15053825	Silent	NA	G90G	0.06
SKCM	chr19	15052206	Splice_Region	novel		0.26
SKCM	chr19	15056044	Silent	NA	N228N	0.38
SKCM	chr19	15055429	Splice_Site	novel	X174_splice	0.21
SKCM	chr19	15055450	Missense_Mutation	NA	D181N	0.11
SKCM	chr19	15053738	Silent	rs377160369	F61F	0.42
SKCM	chr19	15055521	Silent	NA	E204E	0.14
SKCM	chr19	15053551	Missense_Mutation	rs775612358	E33K	0.43
SKCM	chr19	15053522	Missense_Mutation	NA	L23R	0.38
SKCM	chr19	15053632	Splice_Site	NA	X59_splice	0.24
SKCM	chr19	15053599	Missense_Mutation	NA	E49K	0.24
STAD	chr19	15053958	Missense_Mutation	novel	E135K	0.13
STAD	chr19	15053598	Silent	rs751047294	F48F	0.34
STAD	chr19	15055492	Missense_Mutation	NA	F195I	0.43
STAD	chr19	15055438	Missense_Mutation	rs140182507	A177T	0.43
STAD	chr19	15055994	Missense_Mutation	rs200139686	R212W	0.4
STAD	chr19	15055434	Silent	novel	Y175Y	0.23
THCA	chr19	15055444	Nonsense_Mutation	rs546136139	R179*	0.36
UCEC	chr19	15053584	Missense_Mutation	rs61731993	R44W	0.3
UCEC	chr19	15053551	Missense_Mutation	rs775612358	E33K	0.42
UCEC	chr19	15052234	5'UTR	novel		0.29
UCEC	chr19	15055515	Silent	novel	I202I	0.45
UCEC	chr19	15053742	Nonsense_Mutation	novel	E63*	0.1
UCEC	chr19	15053911	Missense_Mutation	novel	A119V	0.21
UCEC	chr19	15055437	Silent	rs765384541	I176I	0.46
UCEC	chr19	15055531	Nonsense_Mutation	novel	E208*	0.26
UCEC	chr19	15053905	Missense_Mutation	novel	C117Y	0.23
UCEC	chr19	15056009	Nonsense_Mutation	novel	E217*	0.58
UCEC	chr19	15053584	Missense_Mutation	rs61731993	R44W	0.5
UCEC	chr19	15053882	Silent	rs549293146	F109F	0.5
UCEC	chr19	15056053	Silent	novel	I231I	0.14
UCEC	chr19	15053551	Missense_Mutation	rs775612358	E33K	0.43
UCEC	chr19	15055509	Silent	novel	G200G	0.34
UCEC	chr19	15053854	Missense_Mutation	novel	G100V	0.43
UCEC	chr19	15052240	5'UTR	novel		0.12
UCEC	chr19	15052228	5'UTR	novel		0.42
UCEC	chr19	15053611	Missense_Mutation	NA	K53Q	0.35
UCEC	chr19	15053599	Missense_Mutation	NA	E49K	0.24
UCEC	chr19	15053882	Silent	rs549293146	F109F	0.36
UCEC	chr19	15055445	Missense_Mutation	rs185297693	R179Q	0.24
UCEC	chr19	15055218	Missense_Mutation	novel	S155N	0.41
UCEC	chr19	15055256	Missense_Mutation	rs148526551	V168I	0.25
UCEC	chr19	15052262	Missense_Mutation	rs201635146	P4L	0.31
UVM	chr19	15055445	Missense_Mutation	rs185297693	R179Q	0.15

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	AMP	0.1602	0.074592
READ	DEL	0.0727	0.23023
THCA	DEL	0.014	0.090402

Survival Analysis

Cancer	P-value	Q-value
STAD	0.04	Kaplan-Meier Survival Analysis
UCS	0.048	Kaplan-Meier Survival Analysis
SKCM	0.00022	Kaplan-Meier Survival Analysis
BRCA	0.016	Kaplan-Meier Survival Analysis
PAAD	0.0014	Kaplan-Meier Survival Analysis
CESC	0.02	Kaplan-Meier Survival Analysis
OV	0.011	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000105141 (Gene tree)
Gene ID: 23581
Gene Symbol: CASP14
Alias: MICE|MGC119078|MGC119079
Full Name: caspase 14
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 8,910 bases
Position: chr19:15,049,384-15,058,293
Accession: 1502
RBP type: non-canonical RBP
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000427043	CASP14-201	3241	XM_011527861	ENSP00000393417	242 (aa)	XP_011526163	P31944
ENST00000598738	CASP14-202	771	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000105141's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105141's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004197	cysteine-type endopeptidase activity	10203698.	TAS	Function
GO:0005515	protein binding	24872419.25416956.	IPI	Function
GO:0005634	nucleus	23377137.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	23377137.	IDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006508	proteolysis	-	IEA	Process
GO:0006915	apoptotic process	21873635.	IBA	Process
GO:0008544	epidermis development	10203698.	TAS	Process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	21873635.	IBA	Process
GO:0031424	keratinization	18309324.	TAS	Process
GO:0045095	keratin filament	-	IEA	Component
GO:0070268	cornification	18309324.	TAS	Process
GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	21873635.	IBA	Function

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.