EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
12176997	Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.	J Biol Chem	2002 Oct 18	Basso AD	-
18089825	Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells.	Cancer Res	2007 Dec 15	Gray PJ Jr	-
28284560	Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells InVitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.	Gastroenterology	2017 Jun	Chen B	doi: 10.1053/j.gastro.2017.02.039
23281476	Novel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen receptor activity and prostate cancer growth.	J Biol Chem	2013 Feb 22	Wu F	doi: 10.1074/jbc.M112.390963
24869908	Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37.	Mol Med	2014 Jul 14	Kim H	doi: 10.2119/molmed.2013.00166.
22912728	Cell surface Cdc37 participates in extracellular HSP90 mediated cancer cell invasion.	PLoS One	2012	El Hamidieh A	doi: 10.1371/journal.pone.0042722
28073914	Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.	J Biol Chem	2017 Feb 17	Li R	doi: 10.1074/jbc.M116.762443

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr19	10393104	Silent	novel	I321I	0.26
ACC	chr19	10396115	Missense_Mutation	novel	C64F	0.18
BLCA	chr19	10395302	Missense_Mutation	rs201914397	D177N	0.14
BLCA	chr19	10396026	Missense_Mutation	novel	E94Q	0.06
BLCA	chr19	10393286	Silent	rs138014063	P294P	0.24
BLCA	chr19	10396068	Missense_Mutation	novel	E80Q	0.19
BLCA	chr19	10393381	Missense_Mutation	novel	V263L	0.13
BRCA	chr19	10391661	Missense_Mutation	NA	V343I	0.17
BRCA	chr19	10395473	Missense_Mutation	novel	T150I	0.04
BRCA	chr19	10395097	Missense_Mutation	novel	Q217P	0.1
BRCA	chr19	10403424	Missense_Mutation	NA	T19M	0.24
BRCA	chr19	10395056	Missense_Mutation	rs779190160	R231W	0.21
CESC	chr19	10391684	Missense_Mutation	rs751173951	R335H	0.21
CESC	chr19	10391532	3'UTR	novel		0.15
CESC	chr19	10391647	Frame_Shift_Ins	novel	*K347Nfs27**	0.1
CESC	chr19	10396141	Silent	rs759946976	R55R	0.15
CESC	chr19	10403411	Silent	NA	I23I	0.16
COAD	chr19	10391685	Missense_Mutation	novel	R335C	0.13
COAD	chr19	10395801	Intron	novel		0.43
COAD	chr19	10395795	Intron	novel		0.38
COAD	chr19	10395360	Intron	novel		0.32
COAD	chr19	10403385	Missense_Mutation	NA	R32L	0.33
COAD	chr19	10393436	Silent	NA	A244A	0.07
COAD	chr19	10395395	Intron	novel		0.26
COAD	chr19	10396067	Missense_Mutation	novel	E80G	0.46
COAD	chr19	10391446	3'UTR	novel		0.27
COAD	chr19	10396058	Missense_Mutation	NA	R83H	0.52
COAD	chr19	10395948	Missense_Mutation	novel	S120G	0.29
COAD	chr19	10393085	Splice_Site	novel	X327_splice	0.09
DLBC	chr19	10395781	Intron	novel		0.88
ESCA	chr19	10403560	5'Flank	novel		0.45
GBM	chr19	10396019	Missense_Mutation	NA	R96Q	0.32
GBM	chr19	10391562	Missense_Mutation	novel	V376I	0.56
GBM	chr19	10395830	Intron	novel		0.2
GBM	chr19	10393276	Missense_Mutation	novel	Y298H	0.26
GBM	chr19	10396055	Missense_Mutation	NA	L84Q	0.43
HNSC	chr19	10395281	Missense_Mutation	rs750412756	E184K	0.38
HNSC	chr19	10396011	Missense_Mutation	novel	E99Q	0.21
HNSC	chr19	10395042	Silent	novel	R235R	0.78
KIRP	chr19	10396199	Missense_Mutation	NA	R36Q	0.54
KIRP	chr19	10395407	Intron	novel		0.55
LGG	chr19	10391368	3'UTR	novel		0.5
LGG	chr19	10391575	Silent	rs373049246	G371G	0.42
LGG	chr19	10395621	Intron	novel		0.43
LIHC	chr19	10396087	Silent	NA	V73V	0.32
LIHC	chr19	10403432	Missense_Mutation	novel	E16D	0.43
LIHC	chr19	10403500	5'UTR	rs766721158		0.11
LUAD	chr19	10391571	Missense_Mutation	novel	E373K	0.11
LUAD	chr19	10393371	Missense_Mutation	rs758820884	R266H	0.11
LUAD	chr19	10395257	Missense_Mutation	NA	I192V	0.16
LUAD	chr19	10393358	Silent	NA	R270R	0.92
LUSC	chr19	10391703	Missense_Mutation	novel	A329T	0.38
LUSC	chr19	10395602	Intron	novel		0.07
LUSC	chr19	10393423	Missense_Mutation	novel	M249V	0.21
LUSC	chr19	10395976	Missense_Mutation	NA	K110N	0.11
LUSC	chr19	10391543	3'UTR	novel		0.42
OV	chr19	10396191	Missense_Mutation	NA	R39C	0.14
OV	chr19	10395258	Silent	novel	V191V	0.07
OV	chr19	10395641	Intron	novel		0.3
OV	chr19	10393359	Missense_Mutation	NA	R270H	0.13
OV	chr19	10393342	Missense_Mutation	novel	K276Q	0.05
PAAD	chr19	10391475	3'UTR	novel		0.05
PAAD	chr19	10395233	Nonsense_Mutation	novel	E200*	0.08
PAAD	chr19	10395831	Intron	novel		0.21
PAAD	chr19	10396078	Silent	rs745696526	G76G	0.2
PRAD	chr19	10396109	Missense_Mutation	NA	R66T	0.17
PRAD	chr19	10395272	Missense_Mutation	novel	A187S	0.06
PRAD	chr19	10396190	Missense_Mutation	NA	R39H	0.38
READ	chr19	10393301	Silent	NA	P289P	0.36
SARC	chr19	10403562	5'Flank	NA		0.8
SKCM	chr19	10403562	5'Flank	NA		0.6
SKCM	chr19	10403562	5'Flank	NA		0.5
SKCM	chr19	10403562	5'Flank	NA		0.3
SKCM	chr19	10393288	Missense_Mutation	novel	P294S	0.08
SKCM	chr19	10396176	Nonsense_Mutation	novel	Q44*	0.09
SKCM	chr19	10391475	3'UTR	novel		0.38
SKCM	chr19	10395513	Missense_Mutation	novel	E137K	0.39
SKCM	chr19	10391667	Missense_Mutation	NA	L341F	0.27
SKCM	chr19	10403562	5'Flank	NA		0.44
SKCM	chr19	10396156	Silent	NA	L50L	0.15
SKCM	chr19	10403583	5'Flank	novel		0.43
STAD	chr19	10391486	3'UTR	novel		0.14
STAD	chr19	10393378	Missense_Mutation	NA	R264W	0.28
STAD	chr19	10396019	Missense_Mutation	NA	R96Q	0.3
STAD	chr19	10396200	Missense_Mutation	NA	R36W	0.29
STAD	chr19	10393321	Missense_Mutation	rs143134175	R283C	0.16
STAD	chr19	10393301	Silent	NA	P289P	0.13
STAD	chr19	10391532	3'UTR	rs201534349		0.3
UCEC	chr19	10393436	Silent	NA	A244A	0.12
UCEC	chr19	10395468	Missense_Mutation	NA	V152M	0.44
UCEC	chr19	10393436	Silent	NA	A244A	0.3
UCEC	chr19	10391675	Missense_Mutation	NA	D338G	0.48
UCEC	chr19	10393432	Missense_Mutation	NA	R246C	0.64
UCEC	chr19	10395400	Intron	novel		0.28
UCEC	chr19	10393143	Silent	novel	C308C	0.44
UCEC	chr19	10393339	Missense_Mutation	novel	E277K	0.31
UCEC	chr19	10391426	3'UTR	novel		0.22
UCEC	chr19	10395656	Intron	novel		0.24
UCEC	chr19	10395571	Intron	novel		0.07
UCEC	chr19	10391380	3'UTR	novel		0.21
UCEC	chr19	10396022	Missense_Mutation	novel	E95A	0.48
UCEC	chr19	10395400	Intron	novel		0.44
UCEC	chr19	10395523	Silent	rs182055971	P133P	0.27
UCEC	chr19	10391391	3'UTR	novel		0.5
UCEC	chr19	10395266	Missense_Mutation	NA	Y189D	0.25
UCEC	chr19	10395942	Missense_Mutation	NA	D122Y	0.13
UCEC	chr19	10395508	Missense_Mutation	novel	E138D	0.19
UCEC	chr19	10396168	In_Frame_Del	novel	E46del	0.13
UCEC	chr19	10395990	Missense_Mutation	rs753612399	R106C	0.35
UCEC	chr19	10395104	Missense_Mutation	novel	V215I	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	DEL	0.0909	0.23023
THCA	DEL	0.014	0.10598
UCS	AMP	0.2857	0.00085866

Survival Analysis

Cancer	P-value	Q-value
STAD	0.0001	Kaplan-Meier Survival Analysis
MESO	0.038	Kaplan-Meier Survival Analysis
ACC	0.00018	Kaplan-Meier Survival Analysis
PRAD	0.015	Kaplan-Meier Survival Analysis
PCPG	0.017	Kaplan-Meier Survival Analysis
BLCA	0.018	Kaplan-Meier Survival Analysis
LAML	0.00043	Kaplan-Meier Survival Analysis
UCEC	0.026	Kaplan-Meier Survival Analysis
LGG	0.023	Kaplan-Meier Survival Analysis
LUAD	0.0091	Kaplan-Meier Survival Analysis
OV	0.023	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000105401 (Gene tree)
Gene ID: 11140
Gene Symbol: CDC37
Alias: P50CDC37
Full Name: cell division cycle 37
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 28,991 bases
Position: chr19:10,391,131-10,420,121
Accession: 1735
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000588869	CDC37-203	966	-	ENSP00000464971	60 (aa)	-	K7EJ06
ENST00000589331	CDC37-204	537	-	ENSP00000464889	104 (aa)	-	K7EIU0
ENST00000222005	CDC37-201	1608	XM_011527652	ENSP00000222005	378 (aa)	XP_011525954	Q16543
ENST00000588498	CDC37-202	690	-	-	- (aa)	-	-
ENST00000589755	CDC37-207	793	-	-	- (aa)	-	-
ENST00000589625	CDC37-205	587	-	ENSP00000465941	184 (aa)	-	K7EL68
ENST00000590632	CDC37-208	601	-	-	- (aa)	-	-
ENST00000593124	CDC37-210	1389	-	ENSP00000465724	353 (aa)	-	K7EKQ2
ENST00000591248	CDC37-209	1377	-	-	- (aa)	-	-
ENST00000589629	CDC37-206	728	-	ENSP00000467747	230 (aa)	-	K7EQA9

Gene Model

Click here to download ENSG00000105401's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04151	PI3K-Akt signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000105401	Inflammatory Bowel Diseases	2E-18	23128233
ENSG00000105401	Crohn Disease	3E-13	28067908
ENSG00000105401	Crohn Disease	5E-20	26192919
ENSG00000105401	Inflammatory Bowel Diseases	2E-11	28067908

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000105401	rs8112449	19	10409388	G	Multiple sclerosis	21833088	[1.07-1.1]	1.08	EFO_0003885
ENSG00000105401	rs8112449	19	10409388	T	Gastritis	25317112	[NR]	1.304	EFO_0000217
ENSG00000105401	rs11879191	19	10402235	A	Crohn's disease	26192919		1.1537393	EFO_0000384
ENSG00000105401	rs35164067	19	10414505	?	Inflammatory bowel disease	26192919			EFO_0003767
ENSG00000105401	rs35164067	19	10414505	G	Ankylosing spondylitis	23749187		1.14	EFO_0003898
ENSG00000105401	rs35164067	19	10414505	G	Ankylosing spondylitis	23749187		1.16	EFO_0003898
ENSG00000105401	rs11879191	19	10402235	?	Crohn's disease	28067908			EFO_0000384
ENSG00000105401	rs11879191	19	10402235	?	Inflammatory bowel disease	28067908			EFO_0003767
ENSG00000105401	rs11879191	19	10402235	G	Inflammatory bowel disease	23128233	[1.096-1.177]	1.136	EFO_0003767

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105401's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	8666233.	TAS	Process
GO:0005515	protein binding	9150368.11036079.12176997.14676191.14743216.16321986.17979178.19026643.19875381.20562859.20642453.21163940.21360678.21871133.21900206.21903422.22612223.22939624.23075850.23428871.23455922.24189400.24366813.24618592.24880080.25036637.25486457.26496610.27086506.27339980.27353360.28330616.29568061.30108113.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006457	protein folding	21873635.	IBA	Process
GO:0006605	protein targeting	8666233.	TAS	Process
GO:0010608	posttranscriptional regulation of gene expression	-	IEA	Process
GO:0019887	protein kinase regulator activity	-	IEA	Function
GO:0019900	kinase binding	21855797.	IPI	Function
GO:0019901	protein kinase binding	-	IEA	Function
GO:0031072	heat shock protein binding	21873635.	IBA	Function
GO:0031072	heat shock protein binding	9660753.	IPI	Function
GO:0038128	ERBB2 signaling pathway	-	TAS	Process
GO:0050821	protein stabilization	21873635.	IBA	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0051087	chaperone binding	21873635.	IBA	Function
GO:0051879	Hsp90 protein binding	-	IEA	Function
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	16280321.	IMP	Process
GO:0060338	regulation of type I interferon-mediated signaling pathway	16280321.	IMP	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0097110	scaffold protein binding	10409742.	IPI	Function
GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	-	IEA	Process
GO:0101031	chaperone complex	29127155.	IDA	Component
GO:1990565	HSP90-CDC37 chaperone complex	21855797.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.