EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20826764	Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.	Science	2010 Oct 8	Jones S	doi: 10.1126/science.1196333
14532964	Reduced expression of the regulatory A subunit of serine/threonine protein phosphatase 2A in human breast cancer MCF-7 cells.	Int J Oncol	2003 Nov	Suzuki K	-
27272709	Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway.	Sci Rep	2016 Jun 7	Jeong AL	doi: 10.1038/srep27391.
21882256	PPP2R1A mutations are common in the serous type of endometrial cancer.	Mol Carcinog	2012 Oct	Nagendra DC	doi: 10.1002/mc.20850
24204789	Functional genetic polymorphisms in PP2A subunit genes confer increased risks of lung cancer in southern and eastern Chinese.	PLoS One	2013 Oct 29	Yang R	doi: 10.1371/journal.pone.0077285
29547736	The presence of KRAS, PPP2R1A and ARID1A mutations in 101 Chinese samples with ovarian endometriosis.	Mutat Res	2018 May	Zou Y	doi: 10.1016/j.mrfmmm.2018.03.001

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr19	52216022	Missense_Mutation	NA	S314L	0.44
BLCA	chr19	52216654	Silent	NA	L373L	0.36
BLCA	chr19	52221124	Silent	NA	F503F	0.45
BLCA	chr19	52215815	Missense_Mutation	novel	D282H	0.12
BLCA	chr19	52202013	Missense_Mutation	novel	E50Q	0.15
BLCA	chr19	52215865	Silent	novel	V298V	0.11
BLCA	chr19	52212730	Frame_Shift_Ins	novel	*A184Gfs21**	0.32
BLCA	chr19	52212733	In_Frame_Del	novel	A185_S187del	0.31
BRCA	chr19	52201992	Frame_Shift_Ins	novel	*G43Efs100**	0.1
BRCA	chr19	52190102	Silent	novel	A2A	0.12
BRCA	chr19	52190114	Silent	NA	G6G	0.11
BRCA	chr19	52212729	Missense_Mutation	NA	R183W	0.54
BRCA	chr19	52226046	3'UTR	novel		0.14
BRCA	chr19	52216591	Silent	novel	L352L	0.1
BRCA	chr19	52225807	Splice_Region	NA	T584T	0.47
BRCA	chr19	52220204	Missense_Mutation	novel	D440H	0.1
BRCA	chr19	52201998	Missense_Mutation	NA	E45Q	0.19
CESC	chr19	52226009	3'UTR	novel		0.37
CESC	chr19	52225967	Splice_Region	novel	L586L	0.44
CESC	chr19	52219688	Splice_Region	novel		0.39
CESC	chr19	52219752	Missense_Mutation	NA	I397N	0.13
CESC	chr19	52213070	Missense_Mutation	NA	S256Y	0.4
CESC	chr19	52211348	Missense_Mutation	NA	S120L	0.32
CESC	chr19	52190239	Intron	novel		0.48
CESC	chr19	52219815	Missense_Mutation	novel	R418Q	0.39
CESC	chr19	52211334	Missense_Mutation	novel	I115M	0.09
CESC	chr19	52212795	Missense_Mutation	novel	I205V	0.07
CESC	chr19	52222215	Silent	novel	Q545Q	0.57
COAD	chr19	52213076	Missense_Mutation	NA	R258H	0.32
COAD	chr19	52212969	Silent	NA	L222L	0.25
COAD	chr19	52212729	Missense_Mutation	NA	R183W	0.78
COAD	chr19	52212729	Missense_Mutation	NA	R183W	0.66
COAD	chr19	52222221	Silent	novel	I547I	0.35
COAD	chr19	52190220	Intron	NA		0.26
COAD	chr19	52212735	Missense_Mutation	NA	A185T	0.26
COAD	chr19	52212729	Missense_Mutation	NA	R183W	0.46
COAD	chr19	52211401	Missense_Mutation	novel	G138S	0.34
COAD	chr19	52222242	Splice_Site	novel	X554_splice	0.27
COAD	chr19	52212729	Missense_Mutation	NA	R183W	0.32
COAD	chr19	52219747	Silent	NA	I395I	0.23
COAD	chr19	52212729	Missense_Mutation	NA	R183W	0.58
COAD	chr19	52212975	Silent	novel	A224A	0.37
COAD	chr19	52211301	Silent	novel	V104V	0.4
COAD	chr19	52211333	Missense_Mutation	novel	I115T	0.26
COAD	chr19	52216610	Missense_Mutation	NA	D359N	0.09
COAD	chr19	52216590	Missense_Mutation	novel	L352P	0.19
ESCA	chr19	52225778	Missense_Mutation	novel	V575I	0.27
ESCA	chr19	52220981	Missense_Mutation	rs746735616	Y456H	0.41
ESCA	chr19	52211432	Missense_Mutation	novel	C148Y	0.35
ESCA	chr19	52213062	Missense_Mutation	novel	E253D	0.29
ESCA	chr19	52226334	3'UTR	novel		0.47
GBM	chr19	52213008	Silent	novel	L235L	0.32
GBM	chr19	52220985	Missense_Mutation	novel	A457V	0.41
GBM	chr19	52211321	Missense_Mutation	novel	S111C	0.16
GBM	chr19	52216033	Silent	rs775654171	R318R	0.61
GBM	chr19	52222151	Missense_Mutation	rs747537922	T524M	0.1
GBM	chr19	52220995	Silent	novel	E460E	0.04
GBM	chr19	52220250	Splice_Site	novel	X455_splice	0.06
HNSC	chr19	52226009	3'UTR	novel		0.17
HNSC	chr19	52220982	Missense_Mutation	novel	Y456C	0.35
HNSC	chr19	52212730	Missense_Mutation	NA	R183Q	0.18
HNSC	chr19	52213109	Missense_Mutation	novel	E269V	0.11
HNSC	chr19	52219735	Silent	novel	V391V	0.34
HNSC	chr19	52206048	Silent	rs760874499	Y85Y	0.18
HNSC	chr19	52221130	Silent	novel	I505I	0.21
HNSC	chr19	52221051	Frame_Shift_Ins	novel	*A480Cfs31**	0.15
KIRP	chr19	52221129	Missense_Mutation	NA	I505T	0.24
KIRP	chr19	52211300	Missense_Mutation	novel	V104G	0.47
LIHC	chr19	52213052	Missense_Mutation	novel	Q250L	0.52
LIHC	chr19	52213081	Missense_Mutation	NA	R260G	0.5
LIHC	chr19	52211489	Missense_Mutation	NA	R167Q	0.38
LUAD	chr19	52222202	Missense_Mutation	NA	A541G	0.3
LUAD	chr19	52212729	Missense_Mutation	NA	R183W	0.37
LUAD	chr19	52215862	Missense_Mutation	novel	E297D	0.08
LUAD	chr19	52206039	Silent	novel	G82G	0.06
LUAD	chr19	52213076	Missense_Mutation	NA	R258H	0.1
LUAD	chr19	52219692	Missense_Mutation	NA	C377F	0.38
LUAD	chr19	52225740	Missense_Mutation	novel	P562H	0.1
LUAD	chr19	52216650	Missense_Mutation	NA	Q372L	0.23
LUAD	chr19	52225780	Silent	NA	V575V	0.1
LUAD	chr19	52211319	Missense_Mutation	novel	E110D	0.27
LUAD	chr19	52216067	Missense_Mutation	NA	C329F	0.23
LUAD	chr19	52211426	Missense_Mutation	NA	S146L	0.05
LUAD	chr19	52216530	Missense_Mutation	novel	E332V	0.31
LUAD	chr19	52221089	Missense_Mutation	novel	D492Y	0.19
LUSC	chr19	52216663	Missense_Mutation	novel	E376D	0.09
LUSC	chr19	52219814	Missense_Mutation	rs770861676	R418W	0.32
LUSC	chr19	52219789	Silent	NA	V409V	0.13
LUSC	chr19	52219790	Nonsense_Mutation	NA	E410*	0.12
LUSC	chr19	52201952	Silent	NA	L29L	0.2
LUSC	chr19	52211420	Missense_Mutation	NA	R144H	0.47
LUSC	chr19	52219779	Missense_Mutation	NA	P406R	0.26
LUSC	chr19	52205974	Missense_Mutation	novel	D61N	0.14
LUSC	chr19	52221085	Silent	rs187141962	S490S	0.21
LUSC	chr19	52225780	Silent	novel	V575V	0.06
LUSC	chr19	52226017	3'UTR	novel		0.06
LUSC	chr19	52220195	Missense_Mutation	NA	E437K	0.27
LUSC	chr19	52211356	Missense_Mutation	NA	D123N	0.11
LUSC	chr19	52212825	Missense_Mutation	NA	D215H	0.26
LUSC	chr19	52219797	Missense_Mutation	NA	A412D	0.11
LUSC	chr19	52222171	Missense_Mutation	NA	D531H	0.13
OV	chr19	52226039	3'UTR	novel		0.18
OV	chr19	52211422	Missense_Mutation	NA	T145P	0.23
OV	chr19	52212718	Missense_Mutation	NA	P179R	0.2
OV	chr19	52213074	Missense_Mutation	NA	W257C	0.21
OV	chr19	52225729	Missense_Mutation	novel	S558R	0.09
OV	chr19	52221110	Frame_Shift_Del	novel	M499*	0.2
OV	chr19	52212729	Missense_Mutation	NA	R183W	0.3
PAAD	chr19	52225762	Missense_Mutation	rs757889759	Q569H	0.19
PAAD	chr19	52206043	Missense_Mutation	novel	E84Q	0.04
PRAD	chr19	52219804	Silent	rs139139629	D414D	0.34
READ	chr19	52201949	Silent	NA	R28R	0.23
READ	chr19	52212828	Missense_Mutation	NA	E216K	0.16
READ	chr19	52220200	Missense_Mutation	NA	F438L	0.43
SARC	chr19	52212718	Missense_Mutation	NA	P179R	0.48
SKCM	chr19	52211261	Frame_Shift_Del	novel	*P91Rfs33**	0.61
SKCM	chr19	52226125	3'UTR	novel		0.22
SKCM	chr19	52211348	Missense_Mutation	NA	S120L	0.1
SKCM	chr19	52220990	Missense_Mutation	novel	R459C	0.51
SKCM	chr19	52205997	Silent	novel	A68A	0.25
SKCM	chr19	52201997	Silent	NA	V44V	0.29
SKCM	chr19	52213028	Missense_Mutation	NA	A242V	0.27
SKCM	chr19	52211417	Missense_Mutation	rs112759633	S143F	0.35
SKCM	chr19	52220221	Silent	NA	S445S	0.23
SKCM	chr19	52212693	Missense_Mutation	NA	R171W	0.11
SKCM	chr19	52219777	Silent	novel	L405L	0.51
SKCM	chr19	52211410	Missense_Mutation	novel	F141L	0.3
SKCM	chr19	52212797	Silent	NA	I205I	0.1
SKCM	chr19	52216008	Silent	NA	F309F	0.12
STAD	chr19	52215796	Silent	NA	G275G	0.11
STAD	chr19	52220231	Missense_Mutation	NA	A449T	0.25
STAD	chr19	52212964	Missense_Mutation	NA	R221W	0.7
STAD	chr19	52225999	3'UTR	novel		0.21
STAD	chr19	52201979	Silent	rs775159886	I38I	0.21
STAD	chr19	52219705	Silent	NA	R381R	0.35
STAD	chr19	52212997	Missense_Mutation	rs769334090	A232T	0.21
STAD	chr19	52212726	Missense_Mutation	rs786205227	R182W	0.23
STAD	chr19	52216541	Missense_Mutation	NA	D336N	0.29
STAD	chr19	52211273	Missense_Mutation	rs148604195	S95L	0.32
STAD	chr19	52212730	Missense_Mutation	NA	R183Q	0.24
STAD	chr19	52221011	Missense_Mutation	NA	L466M	0.07
STAD	chr19	52212765	Missense_Mutation	NA	V195M	0.26
STAD	chr19	52211452	Missense_Mutation	NA	Y155N	0.35
STAD	chr19	52211367	Silent	rs199586303	A126A	0.28
THCA	chr19	52215789	Missense_Mutation	NA	A273V	0.3
THCA	chr19	52215789	Missense_Mutation	NA	A273V	0.39
THYM	chr19	52212768	Missense_Mutation	novel	L196V	0.57
UCEC	chr19	52211419	Missense_Mutation	NA	R144C	0.45
UCEC	chr19	52213075	Missense_Mutation	NA	R258C	0.47
UCEC	chr19	52212832	Missense_Mutation	novel	Q217R	0.24
UCEC	chr19	52220991	Missense_Mutation	novel	R459H	0.58
UCEC	chr19	52213070	Missense_Mutation	NA	S256F	0.31
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.78
UCEC	chr19	52212961	Missense_Mutation	NA	V220M	0.27
UCEC	chr19	52213070	Missense_Mutation	NA	S256F	0.5
UCEC	chr19	52201943	Splice_Site	NA	X27_splice	0.19
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.29
UCEC	chr19	52213076	Missense_Mutation	NA	R258H	0.39
UCEC	chr19	52219821	Missense_Mutation	novel	R420Q	0.12
UCEC	chr19	52216614	Missense_Mutation	novel	N360S	0.41
UCEC	chr19	52226085	3'UTR	novel		0.64
UCEC	chr19	52213070	Missense_Mutation	NA	S256Y	0.34
UCEC	chr19	52211367	Silent	rs199586303	A126A	0.34
UCEC	chr19	52213070	Missense_Mutation	NA	S256F	0.34
UCEC	chr19	52202008	Missense_Mutation	rs770424653	R48Q	0.38
UCEC	chr19	52225746	Missense_Mutation	novel	L564P	0.44
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.33
UCEC	chr19	52201986	Missense_Mutation	NA	A41T	0.43
UCEC	chr19	52212729	Missense_Mutation	NA	R183W	0.52
UCEC	chr19	52212726	Missense_Mutation	rs786205227	R182W	0.52
UCEC	chr19	52215870	Missense_Mutation	rs778644015	A300V	0.4
UCEC	chr19	52211265	Silent	rs765353178	P92P	0.32
UCEC	chr19	52219738	Silent	rs143253734	N392N	0.3
UCEC	chr19	52205989	Missense_Mutation	novel	L66I	0.41
UCEC	chr19	52213073	Missense_Mutation	novel	W257L	0.6
UCEC	chr19	52190176	Splice_Site	novel	X26_splice	0.47
UCEC	chr19	52216074	Splice_Region	NA	K331K	0.52
UCEC	chr19	52212964	Missense_Mutation	NA	R221W	0.21
UCEC	chr19	52221070	Silent	NA	K485K	0.19
UCEC	chr19	52211290	Missense_Mutation	novel	E101K	0.46
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.46
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.5
UCEC	chr19	52211290	Missense_Mutation	novel	E101K	0.49
UCEC	chr19	52212729	Missense_Mutation	NA	R183W	0.09
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.52
UCEC	chr19	52211492	Missense_Mutation	novel	Q168R	0.26
UCEC	chr19	52212711	Missense_Mutation	novel	D177Y	0.23
UCEC	chr19	52212828	Missense_Mutation	NA	E216K	0.29
UCEC	chr19	52213065	Missense_Mutation	novel	D254E	0.08
UCEC	chr19	52211433	Silent	rs752352459	C148C	0.37
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.47
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.52
UCEC	chr19	52213073	Missense_Mutation	novel	W257L	0.55
UCEC	chr19	52190100	Missense_Mutation	novel	A2S	0.27
UCEC	chr19	52226005	3'UTR	novel		0.52
UCEC	chr19	52215802	Missense_Mutation	novel	E277D	0.4
UCEC	chr19	52226334	3'UTR	novel		0.3
UCEC	chr19	52226205	3'UTR	novel		0.1
UCEC	chr19	52226069	3'UTR	novel		0.11
UCEC	chr19	52212729	Missense_Mutation	NA	R183W	0.56
UCEC	chr19	52212729	Missense_Mutation	NA	R183W	0.82
UCEC	chr19	52213079	Missense_Mutation	novel	V259A	0.2
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.3
UCEC	chr19	52213070	Missense_Mutation	NA	S256Y	0.42
UCEC	chr19	52212718	Missense_Mutation	rs786205228	P179L	0.74
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.6
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.32
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.31
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.31
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.58
UCEC	chr19	52212717	Missense_Mutation	novel	P179T	0.15
UCEC	chr19	52220990	Missense_Mutation	novel	R459C	0.71
UCEC	chr19	52212726	Missense_Mutation	rs786205227	R182W	0.35
UCEC	chr19	52222234	Missense_Mutation	novel	D552N	0.35
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.55
UCEC	chr19	52213073	Missense_Mutation	novel	W257L	0.57
UCEC	chr19	52215863	Missense_Mutation	NA	V298L	0.35
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.25
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.23
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.33
UCEC	chr19	52216028	Missense_Mutation	novel	D316G	0.1
UCEC	chr19	52212831	Missense_Mutation	novel	Q217K	0.5
UCEC	chr19	52213073	Missense_Mutation	novel	W257S	0.43
UCEC	chr19	52225992	3'UTR	novel		0.37
UCEC	chr19	52201947	Missense_Mutation	NA	R28C	0.16
UCEC	chr19	52226334	3'UTR	novel		0.48
UCEC	chr19	52211480	Missense_Mutation	rs749322788	A164V	0.14
UCEC	chr19	52213070	Missense_Mutation	NA	S256F	0.52
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.31
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.47
UCEC	chr19	52212699	Missense_Mutation	NA	L173M	0.34
UCEC	chr19	52226389	3'UTR	novel		0.23
UCEC	chr19	52211303	Missense_Mutation	NA	R105Q	0.43
UCEC	chr19	52213013	Missense_Mutation	NA	Q237R	0.48
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.38
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.89
UCEC	chr19	52212729	Missense_Mutation	NA	R183W	0.38
UCEC	chr19	52215865	Silent	NA	V298V	0.48
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.24
UCEC	chr19	52213070	Missense_Mutation	NA	S256F	0.28
UCEC	chr19	52212729	Missense_Mutation	NA	R183G	0.09
UCEC	chr19	52213070	Missense_Mutation	NA	S256F	0.33
UCEC	chr19	52212729	Missense_Mutation	NA	R183W	0.57
UCEC	chr19	52213070	Missense_Mutation	NA	S256Y	0.17
UCEC	chr19	52213070	Missense_Mutation	NA	S256F	0.35
UCEC	chr19	52212718	Missense_Mutation	NA	P179R	0.55
UCEC	chr19	52211395	Missense_Mutation	NA	A136T	0.5
UCEC	chr19	52212730	Missense_Mutation	NA	R183Q	0.42
UCEC	chr19	52219740	Missense_Mutation	novel	E393G	0.33
UCEC	chr19	52212729	Missense_Mutation	NA	R183W	0.6
UCS	chr19	52212959	Missense_Mutation	NA	S219L	0.47
UCS	chr19	52212718	Missense_Mutation	NA	P179R	0.35
UCS	chr19	52212718	Missense_Mutation	NA	P179R	0.44
UCS	chr19	52212718	Missense_Mutation	NA	P179R	0.21
UCS	chr19	52212730	Missense_Mutation	NA	R183Q	0.9
UCS	chr19	52212729	Missense_Mutation	NA	R183W	0.56
UCS	chr19	52212959	Missense_Mutation	NA	S219L	0.78
UCS	chr19	52212718	Missense_Mutation	rs786205228	P179L	0.91
UCS	chr19	52215835	Missense_Mutation	novel	Q288H	0.19
UCS	chr19	52212729	Missense_Mutation	NA	R183W	0.31
UCS	chr19	52213070	Missense_Mutation	NA	S256F	0.25
UCS	chr19	52213070	Missense_Mutation	NA	S256Y	0.27
UCS	chr19	52212831	Missense_Mutation	novel	Q217K	0.45
UCS	chr19	52212718	Missense_Mutation	NA	P179R	0.45
UCS	chr19	52202008	Missense_Mutation	rs770424653	R48Q	0.4
UCS	chr19	52219799	Missense_Mutation	novel	E413K	0.37
UCS	chr19	52211426	Missense_Mutation	NA	S146L	0.12
UVM	chr19	52212730	Missense_Mutation	NA	R183Q	0.35
UVM	chr19	52221002	Missense_Mutation	novel	T463P	0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0881	0.027508
KIRP	DEL	0.0486	0.054726
PAAD	DEL	0.087	0.035089
READ	DEL	0.0909	0.23023
TGCT	DEL	0.2933	0.0046229
UCS	DEL	0.1429	0.12448

Survival Analysis

Cancer	P-value	Q-value
SARC	0.00017	Kaplan-Meier Survival Analysis
MESO	0.0069	Kaplan-Meier Survival Analysis
ACC	0.016	Kaplan-Meier Survival Analysis
UCS	0.041	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
LUSC	0.02	Kaplan-Meier Survival Analysis
ESCA	0.038	Kaplan-Meier Survival Analysis
PAAD	0.011	Kaplan-Meier Survival Analysis
LAML	0.00012	Kaplan-Meier Survival Analysis
LIHC	0.0002	Kaplan-Meier Survival Analysis
LUAD	0.0035	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000105568 (Gene tree)
Gene ID: 5518
Gene Symbol: PPP2R1A
Alias: PR65A|PP2A-Aalpha|PP2AA
Full Name: protein phosphatase 2 scaffold subunit Aalpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 39,732 bases
Position: chr19:52,189,802-52,229,533
Accession: 9302
RBP type: non-canonical RBP
Summary: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000462047	PPP2R1A-204	561	-	-	- (aa)	-	-
ENST00000628959	PPP2R1A-212	117	-	ENSP00000485914	38 (aa)	-	M0QXG4
ENST00000477989	PPP2R1A-209	444	-	ENSP00000471298	66 (aa)	-	M0R0K6
ENST00000495876	PPP2R1A-211	562	-	-	- (aa)	-	-
ENST00000473820	PPP2R1A-208	646	-	-	- (aa)	-	-
ENST00000490868	PPP2R1A-210	668	-	ENSP00000469150	38 (aa)	-	M0QXG4
ENST00000322088	PPP2R1A-201	5380	-	ENSP00000324804	589 (aa)	-	P30153
ENST00000462990	PPP2R1A-205	2730	XM_017026929	ENSP00000470504	410 (aa)	XP_016882418	B3KQV6
ENST00000468280	PPP2R1A-206	688	-	-	- (aa)	-	-
ENST00000391791	PPP2R1A-202	979	-	ENSP00000375668	132 (aa)	-	E9PH38
ENST00000454220	PPP2R1A-203	1233	-	ENSP00000391905	395 (aa)	-	C9J9C1
ENST00000473455	PPP2R1A-207	615	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000105568's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04152	AMPK signaling pathway	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04350	TGF-beta signaling pathway	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa04530	Tight junction	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04730	Long-term depression	KEGG
hsa05142	Chagas disease (American trypanosomiasis)	KEGG
hsa05160	Hepatitis C	KEGG
hsa05165	Human papillomavirus infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000105568's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000105568	PPP2R1A	99	62.887	WBGene00003901	paa-1	99	62.887	Caenorhabditis_elegans
ENSG00000105568	PPP2R1A	99	75.345	FBgn0260439	Pp2A-29B	100	74.450	Drosophila_melanogaster
ENSG00000105568	PPP2R1A	99	86.403	ENSG00000137713	PPP2R1B	98	86.224	Homo_sapiens
ENSG00000105568	PPP2R1A	100	85.610	ENSMUSG00000032058	Ppp2r1b	98	86.735	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000159	protein phosphatase type 2A complex	21873635.	IBA	Component
GO:0000159	protein phosphatase type 2A complex	17055435.17174897.	IDA	Component
GO:0000159	protein phosphatase type 2A complex	11007961.	TAS	Component
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	Process
GO:0000188	inactivation of MAPK activity	11007961.	NAS	Process
GO:0000775	chromosome, centromeric region	16580887.	IDA	Component
GO:0004722	protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0005515	protein binding	8617797.9847399.9857076.11504734.11591705.15761952.16044149.16580887.16764867.17055435.17245430.17274953.17374643.17529992.17540176.17632056.18394995.18715871.18782753.19156129.19293187.19915589.20711181.21075311.21460856.23555304.25150978.25241761.25438055.26496610.26829474.27173435.27588481.28174209.28330616.30611118.	IPI	Function
GO:0005634	nucleus	30611118.	IDA	Component
GO:0005634	nucleus	11007961.	NAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005739	mitochondrion	11007961.	NAS	Component
GO:0005829	cytosol	11007961.	TAS	Component
GO:0006275	regulation of DNA replication	11007961.	NAS	Process
GO:0006355	regulation of transcription, DNA-templated	11007961.	NAS	Process
GO:0006470	protein dephosphorylation	11007961.	TAS	Process
GO:0006672	ceramide metabolic process	11007961.	NAS	Process
GO:0006915	apoptotic process	11007961.	TAS	Process
GO:0007059	chromosome segregation	16580887.	IDA	Process
GO:0007084	mitotic nuclear envelope reassembly	-	TAS	Process
GO:0007143	female meiotic nuclear division	-	IEA	Process
GO:0008380	RNA splicing	11007961.	NAS	Process
GO:0010033	response to organic substance	11007961.	NAS	Process
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0015630	microtubule cytoskeleton	11007961.	NAS	Component
GO:0016020	membrane	11007961.	NAS	Component
GO:0016328	lateral plasma membrane	-	IEA	Component
GO:0019888	protein phosphatase regulator activity	21873635.	IBA	Function
GO:0019888	protein phosphatase regulator activity	11007961.	TAS	Function
GO:0019932	second-messenger-mediated signaling	11007961.	NAS	Process
GO:0030111	regulation of Wnt signaling pathway	11007961.	NAS	Process
GO:0030155	regulation of cell adhesion	11007961.	NAS	Process
GO:0030308	negative regulation of cell growth	11007961.	NAS	Process
GO:0030425	dendrite	-	IEA	Component
GO:0040008	regulation of growth	11360189.	NAS	Process
GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	11007961.	NAS	Process
GO:0043666	regulation of phosphoprotein phosphatase activity	-	IEA	Process
GO:0045595	regulation of cell differentiation	11360189.	NAS	Process
GO:0046982	protein heterodimerization activity	9847399.	IPI	Function
GO:0051232	meiotic spindle elongation	-	IEA	Process
GO:0051306	mitotic sister chromatid separation	-	IEA	Process
GO:0051754	meiotic sister chromatid cohesion, centromeric	-	IEA	Process
GO:0065003	protein-containing complex assembly	9989501.	TAS	Process
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:0070262	peptidyl-serine dephosphorylation	-	IEA	Process
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:1903538	regulation of meiotic cell cycle process involved in oocyte maturation	-	IEA	Process
GO:1990405	protein antigen binding	9847399.	IPI	Function
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	IEA	Process

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Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

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