EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr7	2547326	Nonsense_Mutation	NA	Q94*	0.32
BLCA	chr7	2543770	Missense_Mutation	NA	S208F	0.22
BLCA	chr7	2543852	Missense_Mutation	rs779338983	E181K	0.51
BLCA	chr7	2538227	Missense_Mutation	novel	E770K	0.12
BLCA	chr7	2543183	Intron	novel		0.31
BLCA	chr7	2539883	Silent	NA	L467L	0.55
BLCA	chr7	2539197	Silent	novel	E584E	0.42
BLCA	chr7	2554434	5'UTR	novel		0.42
BLCA	chr7	2538323	Missense_Mutation	NA	E738K	0.18
BLCA	chr7	2543498	Intron	novel		0.09
BLCA	chr7	2538569	Missense_Mutation	novel	E656Q	0.17
BRCA	chr7	2543512	Intron	novel		0.33
CESC	chr7	2542830	Intron	novel		0.28
CESC	chr7	2543297	Missense_Mutation	novel	G277D	0.36
CESC	chr7	2543620	Missense_Mutation	NA	S258L	0.13
CESC	chr7	2540919	Intron	novel		0.09
CESC	chr7	2539850	Silent	novel	L478L	0.22
COAD	chr7	2543882	Missense_Mutation	novel	V171I	0.09
COAD	chr7	2543135	Intron	novel		0.3
COAD	chr7	2542223	Intron	novel		0.19
COAD	chr7	2545020	Nonsense_Mutation	novel	G107*	0.91
COAD	chr7	2541723	Missense_Mutation	rs780327501	P377S	0.21
COAD	chr7	2554445	Splice_Region	novel		0.1
COAD	chr7	2538364	In_Frame_Del	rs762488461	L724del	0.42
COAD	chr7	2537915	3'UTR	novel		0.57
COAD	chr7	2547392	Missense_Mutation	NA	V72I	0.23
COAD	chr7	2544981	Missense_Mutation	rs769006340	R120C	0.21
COAD	chr7	2544976	Silent	novel	S121S	0.54
COAD	chr7	2544934	Silent	NA	S135S	0.2
ESCA	chr7	2543355	Intron	novel		0.18
ESCA	chr7	2539635	Silent	novel	F502F	0.08
ESCA	chr7	2541752	Missense_Mutation	rs774408317	R367H	0.1
ESCA	chr7	2539957	Intron	novel		0.31
GBM	chr7	2541003	Silent	rs368441113	L457L	0.36
GBM	chr7	2554385	Missense_Mutation	novel	L16Q	0.21
GBM	chr7	2541349	Missense_Mutation	NA	R424W	0.23
HNSC	chr7	2543110	Intron	novel		0.31
HNSC	chr7	2541753	Missense_Mutation	rs139472984	R367C	0.32
HNSC	chr7	2543330	Splice_Region	novel		0.21
KIRC	chr7	2538219	Silent	NA	V772V	0.54
KIRP	chr7	2541295	Splice_Region	novel		0.16
KIRP	chr7	2547400	Missense_Mutation	NA	S69T	0.46
KIRP	chr7	2542178	Silent	novel	V319V	0.5
KIRP	chr7	2538284	Missense_Mutation	novel	T751P	0.2
LGG	chr7	2543290	Silent	novel	L279L	0.33
LGG	chr7	2543661	Silent	NA	V244V	0.11
LGG	chr7	2538425	Missense_Mutation	rs772032271	A704T	0.16
LIHC	chr7	2539845	Missense_Mutation	NA	S480N	0.4
LUAD	chr7	2543805	Missense_Mutation	NA	Q196H	0.39
LUAD	chr7	2539304	Missense_Mutation	NA	L549V	0.45
LUAD	chr7	2543246	Missense_Mutation	NA	H294R	0.21
LUAD	chr7	2538317	Missense_Mutation	novel	R740W	0.22
LUAD	chr7	2554349	Missense_Mutation	NA	C28F	0.23
LUAD	chr7	2538180	Silent	novel	R785R	0.18
LUSC	chr7	2538569	Nonsense_Mutation	novel	E656*	0.39
LUSC	chr7	2538032	3'UTR	novel		0.74
LUSC	chr7	2543959	Missense_Mutation	rs140833277	A145V	0.19
LUSC	chr7	2538056	3'UTR	novel		0.37
LUSC	chr7	2543301	Missense_Mutation	novel	D276Y	0.33
LUSC	chr7	2543678	Missense_Mutation	rs758480762	R239W	0.1
LUSC	chr7	2541350	Silent	NA	V423V	0.3
LUSC	chr7	2543453	Intron	novel		0.26
LUSC	chr7	2538388	Missense_Mutation	rs140802292	A716V	0.06
OV	chr7	2543826	Frame_Shift_Ins	novel	D190*	0.06
OV	chr7	2543741	Missense_Mutation	novel	L218V	0.11
PRAD	chr7	2543217	Missense_Mutation	rs777504857	K304Q	0.22
PRAD	chr7	2543615	Missense_Mutation	rs774718814	V260M	0.09
SARC	chr7	2541809	Missense_Mutation	novel	A348V	0.69
SARC	chr7	2538597	Silent	novel	L646L	0.25
SARC	chr7	2542834	Intron	novel		0.11
SKCM	chr7	2543631	Silent	rs143192367	P254P	0.22
SKCM	chr7	2543632	Missense_Mutation	novel	P254L	0.22
SKCM	chr7	2543620	Missense_Mutation	NA	S258L	0.6
SKCM	chr7	2538733	Missense_Mutation	NA	S601F	0.46
SKCM	chr7	2543313	Missense_Mutation	NA	F272I	0.22
SKCM	chr7	2543344	Intron	novel		0.33
SKCM	chr7	2543332	Intron	novel		0.11
SKCM	chr7	2539801	Missense_Mutation	novel	P495T	0.29
SKCM	chr7	2539891	Splice_Region	novel		0.47
SKCM	chr7	2543792	Missense_Mutation	NA	H201Y	0.26
SKCM	chr7	2543628	Silent	novel	A255A	0.29
SKCM	chr7	2543591	Missense_Mutation	rs145047426	R268C	0.2
SKCM	chr7	2543616	Silent	rs557291535	F259F	0.64
SKCM	chr7	2541790	Silent	NA	L354L	0.09
SKCM	chr7	2538363	Silent	NA	L724L	0.21
SKCM	chr7	2547385	Missense_Mutation	NA	S74F	0.41
SKCM	chr7	2543212	Silent	NA	L305L	0.09
SKCM	chr7	2541374	Silent	novel	L415L	0.2
SKCM	chr7	2538426	Silent	rs745775567	F703F	0.28
SKCM	chr7	2543613	Silent	NA	V260V	0.33
SKCM	chr7	2541323	Silent	rs141653707	F432F	0.21
SKCM	chr7	2538129	Silent	NA	L802L	0.61
SKCM	chr7	2538247	Missense_Mutation	NA	P763L	0.34
SKCM	chr7	2543580	Intron	novel		0.4
SKCM	chr7	2541393	Missense_Mutation	NA	S409F	0.28
SKCM	chr7	2543681	Missense_Mutation	novel	V238M	0.19
STAD	chr7	2538101	Missense_Mutation	NA	F812I	0.33
STAD	chr7	2539246	Missense_Mutation	novel	A568V	0.18
STAD	chr7	2554417	Silent	NA	C5C	0.13
STAD	chr7	2538145	Frame_Shift_Del	novel	*K797Efs81**	0.17
STAD	chr7	2543372	Intron	novel		0.08
STAD	chr7	2540980	Missense_Mutation	NA	T465M	0.28
STAD	chr7	2543709	Silent	NA	C228C	0.32
STAD	chr7	2543565	Intron	novel		0.06
STAD	chr7	2543746	Missense_Mutation	novel	Q216R	0.21
STAD	chr7	2538158	Missense_Mutation	rs759036645	D793N	0.3
STAD	chr7	2538533	Missense_Mutation	NA	P668S	0.3
STAD	chr7	2538235	Missense_Mutation	NA	Q767R	0.12
STAD	chr7	2543276	Missense_Mutation	rs750645922	A284V	0.32
STAD	chr7	2554416	Missense_Mutation	NA	A6T	0.29
STAD	chr7	2543848	Missense_Mutation	NA	G182V	0.34
STAD	chr7	2543057	Intron	novel		0.16
STAD	chr7	2541381	Frame_Shift_Del	novel	*G413Afs34**	0.39
STAD	chr7	2538703	Missense_Mutation	novel	A611V	0.25
STAD	chr7	2539190	Missense_Mutation	NA	E587K	0.18
STAD	chr7	2543584	Splice_Region	novel		0.36
TGCT	chr7	2541018	Silent	novel	V452V	0.36
THCA	chr7	2543317	Silent	rs775096485	P270P	0.36
UCEC	chr7	2542320	Intron	novel		0.27
UCEC	chr7	2538426	Silent	rs745775567	F703F	0.21
UCEC	chr7	2538314	Missense_Mutation	NA	G741C	0.54
UCEC	chr7	2538359	Silent	novel	L726L	0.29
UCEC	chr7	2543321	Missense_Mutation	novel	S269Y	0.36
UCEC	chr7	2542834	Intron	novel		0.22
UCEC	chr7	2540994	Silent	NA	P460P	0.73
UCEC	chr7	2538346	Missense_Mutation	rs143963658	I730T	0.4
UCEC	chr7	2539577	Missense_Mutation	novel	E522K	0.08
UCEC	chr7	2541436	Missense_Mutation	novel	V395M	0.5
UCEC	chr7	2539806	Missense_Mutation	novel	L493P	0.19
UCEC	chr7	2538387	Silent	rs756583395	A716A	0.41
UCEC	chr7	2543790	Silent	rs529393784	H201H	0.46
UCEC	chr7	2538461	Missense_Mutation	NA	L692M	0.24
UCEC	chr7	2539634	Missense_Mutation	novel	P503T	0.1
UCEC	chr7	2539857	Missense_Mutation	NA	R476M	0.19
UCEC	chr7	2554355	Missense_Mutation	NA	D26G	0.11
UCEC	chr7	2543017	Intron	novel		0.22
UCEC	chr7	2543270	Missense_Mutation	novel	A286D	0.17
UCEC	chr7	2541821	Missense_Mutation	rs371239207	T344M	0.18
UCEC	chr7	2541803	Missense_Mutation	rs755296109	T350M	0.35
UCEC	chr7	2538402	Silent	rs149690979	C711C	0.13
UCEC	chr7	2544922	Missense_Mutation	novel	F139L	0.44
UCEC	chr7	2547389	Missense_Mutation	novel	L73I	0.51
UCEC	chr7	2543666	Missense_Mutation	rs749451094	R243C	0.4
UCEC	chr7	2542142	Silent	rs76646873	T331T	0.36
UCEC	chr7	2537926	3'UTR	novel		0.23
UCEC	chr7	2543135	Intron	novel		0.19
UCEC	chr7	2543536	Intron	novel		0.43
UCEC	chr7	2554349	Missense_Mutation	novel	C28Y	0.18
UCEC	chr7	2540930	Intron	novel		0.28
UCEC	chr7	2537910	3'UTR	novel		0.26
UCEC	chr7	2542609	Intron	novel		0.28
UCEC	chr7	2538443	Missense_Mutation	rs781355172	V698M	0.33
UCEC	chr7	2538663	Silent	novel	H624H	0.41
UCEC	chr7	2542712	Intron	novel		0.28
UCEC	chr7	2543053	Intron	novel		0.39
UCEC	chr7	2543616	Silent	rs557291535	F259F	0.36
UCEC	chr7	2539333	Missense_Mutation	rs762435787	C539Y	0.5
UCEC	chr7	2542536	Intron	novel		0.44
UCEC	chr7	2543826	Frame_Shift_Ins	novel	D190*	0.48
UCEC	chr7	2539804	Missense_Mutation	NA	I494V	0.33
UCEC	chr7	2543606	Missense_Mutation	novel	L263I	0.31
UCEC	chr7	2543927	Missense_Mutation	novel	S156P	0.24
UCEC	chr7	2543301	Missense_Mutation	rs146546197	D276N	0.14
UCEC	chr7	2543088	Intron	novel		0.25
UCEC	chr7	2538129	Silent	NA	L802L	0.08
UCEC	chr7	2539557	Silent	rs768471054	S528S	0.46
UCEC	chr7	2543827	Frame_Shift_Del	novel	*G189Vfs30**	0.29
UCEC	chr7	2544956	Missense_Mutation	rs369391505	R128H	0.38
UCEC	chr7	2538333	Silent	NA	S734S	0.2
UCEC	chr7	2539891	Splice_Region	novel		0.51
UCEC	chr7	2539260	Silent	rs146276208	A563A	0.41
UCEC	chr7	2542326	Intron	novel		0.42
UCEC	chr7	2554342	Missense_Mutation	novel	E30D	0.06
UCEC	chr7	2543048	Intron	novel		0.42
UCEC	chr7	2547356	Missense_Mutation	rs773430061	A84T	0.38
UCEC	chr7	2538011	3'UTR	rs1043297		0.37
UCEC	chr7	2538494	Missense_Mutation	rs145833100	E681K	0.37
UCEC	chr7	2542221	Intron	novel		0.42
UCEC	chr7	2542663	Intron	novel		0.38
UCEC	chr7	2543299	Silent	rs758287252	D276D	0.11
UCEC	chr7	2538633	Silent	NA	F634F	0.17
UCEC	chr7	2547397	Missense_Mutation	novel	S70F	0.28

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.5556	0.24436
BRCA	DEL	0.0991	0.056864
DLBC	AMP	0.3333	0.13215
LGG	DEL	0.0292	0.077684
LUAD	AMP	0.4593	0.17291
OV	DEL	0.4007	3.8574e-27
SKCM	AMP	0.4932	0.00015162
STAD	AMP	0.4354	0.0078915
TGCT	AMP	0.7133	0.019484
THCA	DEL	0	0.27619

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.039	Kaplan-Meier Survival Analysis
ACC	0.00045	Kaplan-Meier Survival Analysis
SKCM	0.00019	Kaplan-Meier Survival Analysis
COAD	0.017	Kaplan-Meier Survival Analysis
PAAD	0.00014	Kaplan-Meier Survival Analysis
UCEC	0.031	Kaplan-Meier Survival Analysis
GBM	0.023	Kaplan-Meier Survival Analysis
LIHC	0.0065	Kaplan-Meier Survival Analysis
DLBC	0.018	Kaplan-Meier Survival Analysis
LGG	0.0003	Kaplan-Meier Survival Analysis
CHOL	0.0097	Kaplan-Meier Survival Analysis
UVM	0.0011	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000106009 (Gene tree)
Gene ID: 221927
Gene Symbol: BRAT1
Alias: MGC22916|C7orf27|BAAT1
Full Name: BRCA1 associated ATM activator 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 17,949 bases
Position: chr7:2,537,810-2,555,758
Accession: 21701
RBP type: non-canonical RBP
Summary: The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000340611	BRAT1-201	2915	XM_011515177	ENSP00000339637	821 (aa)	XP_011513479	Q6PJG6
ENST00000473879	BRAT1-205	666	-	-	- (aa)	-	-
ENST00000467558	BRAT1-203	4440	-	-	- (aa)	-	-
ENST00000421712	BRAT1-202	823	-	ENSP00000409209	168 (aa)	-	F8WDN5
ENST00000493232	BRAT1-206	5360	-	-	- (aa)	-	-
ENST00000469750	BRAT1-204	5226	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000106009's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000106009	Energy Metabolism	5E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000106009	rs6972204	7	2542818	G	Obesity-related traits	23251661	[NR] kcal/min increase	0.03	EFO_0005109

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000106009's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001934	positive regulation of protein phosphorylation	22977523.	IMP	Process
GO:0005515	protein binding	16452482.22977523.25631046.25657994.	IPI	Function
GO:0005634	nucleus	16452482.25631046.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	25631046.	IDA	Component
GO:0006006	glucose metabolic process	25070371.	IMP	Process
GO:0006915	apoptotic process	25070371.	IMP	Process
GO:0006974	cellular response to DNA damage stimulus	25631046.	IMP	Process
GO:0008283	cell proliferation	25070371.	IMP	Process
GO:0010212	response to ionizing radiation	16452482.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016477	cell migration	25070371.	IMP	Process
GO:0030307	positive regulation of cell growth	25070371.	IMP	Process
GO:0051646	mitochondrion localization	25070371.	IMP	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.