EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22534325	Increased expression of heat shock protein 27 correlates with peritoneal metastasis in epithelial ovarian cancer.	Reprod Sci	2012 Jul	Zhao M	doi: 10.1177/1933719111432875
18320359	P-cadherin and beta-catenin are useful prognostic markers in breast cancer patients; beta-catenin interacts with heat shock protein Hsp27.	Cell Stress Chaperones	2008 Summer	Fanelli MA	doi: 10.1007/s12192-007-0007-z
25519015	Relationship between the expression of phosphorylated heat shock protein beta-1 with lymph node metastases of breast cancer.	Cancer Biomark	2015	Kaigorodova EV	doi: 10.3233/CBM-140446.
26744531	HSPB1 Inhibits the Endothelial-to-Mesenchymal Transition to Suppress Pulmonary Fibrosis and Lung Tumorigenesis.	Cancer Res	2016 Mar 1	Choi SH	doi: 10.1158/0008-5472.CAN-15-0952
27022067	A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers.	Ann Oncol	2016 Jun	Chi KN	doi: 10.1093/annonc/mdw068
23264215	Hsp-27 expression in invasive ductal breast carcinoma.	Folia Histochem Cytobiol	2012	Grzegrzolka J	doi: 10.5603/16717.
22185976	Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses.	Cancer Prev Res (Phila)	2012 Jan	Nagaraja GM	doi: 10.1158/1940-6207.CAPR-11-0121
20439495	Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane.	Mol Cell Biol	2010 Jul	Razandi M	doi: 10.1128/MCB.01354-09
26782567	Potential role of heat-shock proteins in giant cell tumors.	Genet Mol Res	2015 Dec 29	Chen JT	doi: 10.4238/2015.December.29.24.
27354654	Expression of HSP27 in Hepatocellular Carcinoma.	Anticancer Res	2016 Jul	Eto D	-
16340246	Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell.	Tumour Biol	2006	Bausero MA	-
18950704	HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination.	Cell Signal	2009 Jan	Wu Y	doi: 10.1016/j.cellsig.2008.10.001
16240287	Heat-shock protein 27: a potential biomarker for hepatocellular carcinoma identified by serum proteome analysis.	Proteomics	2005 Nov	Feng JT	-
27555231	Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer.	Sci Rep	2016 Aug 24	Vahid S	doi: 10.1038/srep31842.
29332450	Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics.	Technol Cancer Res Treat	2017 Dec	Zhao S	doi: 10.1177/1533034617732426
21566277	Experimental study of HSP27 differential expression in left sided colon cancer and right sided colon cancer.	Zhong Nan Da Xue Xue Bao Yi Xue Ban	2011 Apr	Pei H	doi: 10.3969/j.issn.1672-7347.2011.04.001.
22886594	Heat shock protein 27 expression is inversely correlated with atrophic gastritis and intraepithelial neoplasia.	Dig Dis Sci	2013 Feb	Nagata Y	doi: 10.1007/s10620-012-2342-x
22362414	Effect of the heat shock protein HSP27 on androgen receptor expression and function in prostate cancer cells.	World J Urol	2012 Jun	Stope MB	doi: 10.1007/s00345-012-0843-z
25740245	Hsp27 Inhibition with OGX-427 Sensitizes Non-Small Cell Lung Cancer Cells to Erlotinib and Chemotherapy.	Mol Cancer Ther	2015 May	Lelj-Garolla B	doi: 10.1158/1535-7163.MCT-14-0866
22465083	Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70: a multi-institutional case-control study.	Clin Chim Acta	2012 Jul 11	Zimmermann M	doi: 10.1016/j.cca.2012.03.008
25811031	Associations of LIG4 and HSPB1 genetic polymorphisms with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy.	Biomed Res Int	2015	Xu F	doi: 10.1155/2015/860373
19767773	Heat shock protein 27 mediates repression of androgen receptor function by protein kinase D1 in prostate cancer cells.	Oncogene	2009 Dec 10	Hassan S	doi: 10.1038/onc.2009.291.
20231684	Functional promoter -1271G>C variant of HSPB1 predicts lung cancer risk and survival.	J Clin Oncol	2010 Apr 10	Guo H	doi: 10.1200/JCO.2009.24.4954
18949417	Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer.	Oncol Rep	2008 Nov	Tsuruta M	-
24798191	Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression.	Oncotarget	2014 May 15	Voll EA	-
25615626	Ratio of phosphorylated HSP27 to nonphosphorylated HSP27 biphasically acts as a determinant of cellular fate in gemcitabine-resistant pancreatic cancer cells.	Cell Signal	2015 Apr	Kang D	doi: 10.1016/j.cellsig.2015.01.007
24403454	Active hexose-correlated compound down-regulates HSP27 of pancreatic cancer cells, and helps the cytotoxic effect of gemcitabine.	Anticancer Res	2014 Jan	Suenaga S	-
16407830	MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer.	Oncogene	2006 May 18	Xu L	-
19707199	Hsp-27 expression at diagnosis predicts poor clinical outcome in prostate cancer independent of ETS-gene rearrangement.	Br J Cancer	2009 Oct 6	Foster CS	doi: 10.1038/sj.bjc.6605227
25793600	Stromal expression of heat-shock protein 27 is associated with worse clinical outcome in patients with colorectal cancer lung metastases.	PLoS One	2015 Mar 20	Schweiger T	doi: 10.1371/journal.pone.0120724
24882106	An investigation of heat shock protein 27 and P-glycoprotein mediated multi-drug resistance in breast cancer using liquid chromatography-tandem mass spectrometry-based targeted proteomics.	J Proteomics	2014 Aug 28	Xu F	doi: 10.1016/j.jprot.2014.05.016
24950183	Epidermal growth factor/heat shock protein 27 pathway regulates vasculogenic mimicry activity of breast cancer stem/progenitor cells.	Biochimie	2014 Sep	Lee CH	doi: 10.1016/j.biochi.2014.06.011
23453029	Promoter hypermethylation of the gene encoding heat shock protein B1 in oral squamous carcinoma cells.	Oral Surg Oral Med Oral Pathol Oral Radiol	2013 Mar	Wang HC	doi: 10.1016/j.oooo.2012.12.011.
26348464	The Effects of HSP27 on Gemcitabine-Resistant Pancreatic Cancer Cell Line Through Snail.	Pancreas	2015 Oct	Zhang S	doi: 10.1097/MPA.0000000000000418.
18800238	The level of Hsp27 in lymphocytes is negatively associated with a higher risk of lung cancer.	Cell Stress Chaperones	2009 May	Wang F	doi: 10.1007/s12192-008-0078-5
26805817	The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer.	Int J Mol Sci	2016 Jan 21	Okuno M	doi: 10.3390/ijms17010137.
24061637	Heat shock protein 27: a potential biomarker of peritoneal metastasis in epithelial ovarian cancer?	Tumour Biol	2014 Feb	Zhao M	doi: 10.1007/s13277-013-1139-7
17342744	HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells.	Prostate	2007 May 15	Dall'Era MA	-
25193387	DNA methylation gene-based models indicating independent poor outcome in prostate cancer.	BMC Cancer	2014 Sep 6	Vasiljevi N	doi: 10.1186/1471-2407-14-655.
22535481	High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer.	Cell Oncol (Dordr)	2012 Jun	Bauer K	doi: 10.1007/s13402-012-0079-3
25231055	Immediate and transient phosphorylation of the heat shock protein 27 initiates chemoresistance in prostate cancer cells.	Oncol Rep	2014 Dec	Stope MB	doi: 10.3892/or.2014.3492
23848600	Upregulation of heat shock protein 27 confers resistance to actinomycin D-induced apoptosis in cancer cells.	FEBS J	2013 Sep	Ma W	doi: 10.1111/febs.12432
23185379	Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.	PLoS One	2012	Lin SP	doi: 10.1371/journal.pone.0049605
22982087	HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53.	Exp Mol Pathol	2013 Feb	Ghosh A	doi: 10.1016/j.yexmp.2012.09.001
22647853	LEDGF gene silencing impairs the tumorigenicity of prostate cancer DU145 cells by abating the expression of Hsp27 and activation of the Akt/ERK signaling pathway.	Cell Death Dis	2012 May 31	Bhargavan B	doi: 10.1038/cddis.2012.57.
24222130	Shortened isoforms of the androgen receptor are regulated by the cytoprotective heat-shock protein HSPB1 and the tumor-suppressive microRNA miR-1 in prostate cancer cells.	Anticancer Res	2013 Nov	Stope MB	-
26711786	Heat shock protein 27 and gross cystic disease fluid protein 15 play critical roles in molecular apocrine breast cancer.	Tumour Biol	2016 Jun	Liu X	doi: 10.1007/s13277-015-4712-4
23996744	HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor.	Int J Cancer	2014 Mar 15	Pavan S	doi: 10.1002/ijc.28464
22004109	Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma.	J Cell Mol Med	2012 Aug	Schfer C	doi: 10.1111/j.1582-4934.2011.01473.x.
22023707	Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-??B.	Breast Cancer Res	2011 Oct 24	Wei L	doi: 10.1186/bcr3042.
25728673	HSPB1 as a novel regulator of ferroptotic cancer cell death.	Oncogene	2015 Nov 5	Sun X	doi: 10.1038/onc.2015.32
28347227	Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells.	Tumour Biol	2017 Mar	Cai Q	doi: 10.1177/1010428317695015.
26872057	The molecular and clinical verification of therapeutic resistance via the p38 MAPK-Hsp27 axis in lung cancer.	Oncotarget	2016 Mar 22	Liu CL	doi: 10.18632/oncotarget.7306.
26895107	The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer.	Oncotarget	2016 Mar 22	Okuno M	doi: 10.18632/oncotarget.7424.
27449291	Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules.	Oncotarget	2016 Aug 16	Kim JH	doi: 10.18632/oncotarget.10629.
28656293	Anti-proliferation and anti-metastasis effect of barbaloin in non-small cell lung cancer via inactivating p38MAPK/Cdc25B/Hsp27 pathway.	Oncol Rep	2017 Aug	Zhang Z	doi: 10.3892/or.2017.5760
28935773	A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial.	Oncologist	2017 Dec	Ko AH	doi: 10.1634/theoncologist.2017-0066
30056019	Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation.	Life Sci	2018 Sep 15	Liang HH	doi: 10.1016/j.lfs.2018.07.047
29936456	Enzyme-treated Asparagus Extract Down-regulates Heat Shock Protein 27 of Pancreatic Cancer Cells.	In Vivo	2018 Jul-Aug	Shimada T	doi: 10.21873/invivo.11305.
30396985	HSP27, ALDH6A1 and Prohibitin Act as a Trio-biomarker to Predict Survival in Late Metastatic Prostate Cancer.	Anticancer Res	2018 Nov	Cho SY	doi: 10.21873/anticanres.13021.
30106436	Decreasing O-GlcNAcylation affects the malignant transformation of MCF-7 cells via Hsp27 expression and its O-GlcNAc modification.	Oncol Rep	2018 Oct	Netsirisawan P	doi: 10.3892/or.2018.6617

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr7	76304138	Frame_Shift_Del	novel	*E195Rfs6**	0.19
BLCA	chr7	76303825	Missense_Mutation	novel	E130K	0.1
BRCA	chr7	76304224	3'UTR	novel		0.13
BRCA	chr7	76304065	Silent	novel	P170P	0.19
COAD	chr7	76302953	Missense_Mutation	NA	L81I	0.7
COAD	chr7	76304221	3'UTR	novel		0.09
COAD	chr7	76304056	Silent	novel	A167A	0.38
HNSC	chr7	76302659	5'UTR	novel		0.23
LIHC	chr7	76302713	Translation_Start_Site	novel	M1?	0.25
LUAD	chr7	76304129	Missense_Mutation	novel	G192W	0.27
LUSC	chr7	76303850	Missense_Mutation	novel	F138C	0.2
LUSC	chr7	76304167	Silent	NA	A204A	0.18
OV	chr7	76302741	Missense_Mutation	rs772216758	L10H	0.32
SKCM	chr7	76303690	Intron	novel		0.5
SKCM	chr7	76304099	Missense_Mutation	rs104894020	P182S	0.3
SKCM	chr7	76304091	Missense_Mutation	NA	I179N	0.26
STAD	chr7	76302805	Silent	rs761051758	Q31Q	0.31
STAD	chr7	76303987	Frame_Shift_Ins	rs747325717	*G147Rfs14**	0.28
UCEC	chr7	76303988	Frame_Shift_Del	NA	*G147Vfs17**	0.45
UCEC	chr7	76304068	Missense_Mutation	novel	K171N	0.44
UCEC	chr7	76304295	3'UTR	novel		0.21
UCS	chr7	76304028	Missense_Mutation	novel	S158F	0.23

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.2708	0.13215
TGCT	AMP	0.6933	0.035574
THCA	DEL	0.002	0.27619

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0024	Kaplan-Meier Survival Analysis
SARC	0.00088	Kaplan-Meier Survival Analysis
MESO	0.023	Kaplan-Meier Survival Analysis
ACC	0.0011	Kaplan-Meier Survival Analysis
HNSC	0.034	Kaplan-Meier Survival Analysis
SKCM	0.0016	Kaplan-Meier Survival Analysis
KIRP	0.031	Kaplan-Meier Survival Analysis
COAD	0.0058	Kaplan-Meier Survival Analysis
READ	0.002	Kaplan-Meier Survival Analysis
LAML	0.00076	Kaplan-Meier Survival Analysis
KICH	0.0088	Kaplan-Meier Survival Analysis
UCEC	0.005	Kaplan-Meier Survival Analysis
GBM	0.0015	Kaplan-Meier Survival Analysis
LIHC	0.011	Kaplan-Meier Survival Analysis
UVM	0.043	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000106211 (Gene tree)
Gene ID: 3315
Gene Symbol: HSPB1
Alias: HSP27|HSP28|Hs.76067|Hsp25|CMT2F
Full Name: heat shock protein family B (small) member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 1,754 bases
Position: chr7:76,302,544-76,304,297
Accession: 5246
RBP type: non-canonical RBP
Summary: This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19940440	Potential contributions of heat shock proteins to temperature-dependent sex determination in the American alligator.	Sex Dev	2010	Kohno S	doi: 10.1159/000260374
28077174	Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease.	Acta Neuropathol Commun	2017 Jan 11	Geuens T	doi: 10.1186/s40478-016-0407-3.
30696738	Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1.	MBio	2019 Jan 29	Xu J	doi: 10.1128/mBio.02687-18.
15833836	Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.	Cancer Res	2005 Apr 15	Lee SA	-
17623797	Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide.	J Natl Cancer Inst	2007 Jul 18	Keshelava N	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000248553	HSPB1-201	909	-	ENSP00000248553	205 (aa)	-	P04792
ENST00000447574	HSPB1-203	1455	-	ENSP00000414357	186 (aa)	-	F8WE04
ENST00000429938	HSPB1-202	527	-	ENSP00000405285	37 (aa)	-	C9J3N8

Gene Model

Click here to download ENSG00000106211's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04010	MAPK signaling pathway	KEGG
hsa04370	VEGF signaling pathway	KEGG
hsa05146	Amoebiasis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000106211	Platelet Function Tests	2.9969500E-005	-
ENSG00000106211	Multiple Sclerosis	6E-6	21654844
ENSG00000106211	S-(3-hydroxypropyl)cysteine N-acetate	2E-6	26053186
ENSG00000106211	Smoking	2E-6	26053186
ENSG00000106211	Multiple Sclerosis	8E-6	21654844

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000106211's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000106211	HSPB1	100	83.254	ENSMUSG00000004951	Hspb1	100	84.354	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000502	proteasome complex	-	ISS	Component
GO:0001895	retina homeostasis	23580065.	HEP	Process
GO:0001932	regulation of protein phosphorylation	23728742.	IMP	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005080	protein kinase C binding	-	ISS	Function
GO:0005515	protein binding	11003656.12601044.14594798.15161933.15657067.16169070.17184779.17342744.18330356.20467437.20618440.21157431.21575178.22365833.23188086.23397142.23948568.24189400.25036637.25241761.25277244.26496610.	IPI	Function
GO:0005615	extracellular space	22664934.23580065.	HDA	Component
GO:0005634	nucleus	19464326.	IDA	Component
GO:0005737	cytoplasm	19464326.28144995.	IDA	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005819	spindle	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	16130169.	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006446	regulation of translational initiation	10859165.	TAS	Process
GO:0006469	negative regulation of protein kinase activity	-	ISS	Process
GO:0006986	response to unfolded protein	1560006.	NAS	Process
GO:0008426	protein kinase C inhibitor activity	-	ISS	Function
GO:0009615	response to virus	16548883.	IEP	Process
GO:0010506	regulation of autophagy	25962073.	NAS	Process
GO:0019901	protein kinase binding	8774846.	IPI	Function
GO:0030018	Z disc	-	IEA	Component
GO:0032731	positive regulation of interleukin-1 beta production	-	ISS	Process
GO:0035556	intracellular signal transduction	18440775.	IMP	Process
GO:0035924	cellular response to vascular endothelial growth factor stimulus	18440775.	IMP	Process
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	18440775.	IMP	Process
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	-	ISS	Process
GO:0042802	identical protein binding	20178975.23948568.	IMP	Function
GO:0042802	identical protein binding	11003656.22365833.25036637.25277244.	IPI	Function
GO:0042803	protein homodimerization activity	28144995.	IDA	Function
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	-	ISS	Process
GO:0043130	ubiquitin binding	-	ISS	Function
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043536	positive regulation of blood vessel endothelial cell migration	18440775.	IMP	Process
GO:0044183	protein binding involved in protein folding	20178975.	IMP	Function
GO:0045766	positive regulation of angiogenesis	18440775.	IMP	Process
GO:0061077	chaperone-mediated protein folding	20178975.23948568.	IMP	Process
GO:0070062	extracellular exosome	19056867.19199708.23533145.	HDA	Component
GO:0070527	platelet aggregation	23382103.	HMP	Process
GO:0071901	negative regulation of protein serine/threonine kinase activity	-	IEA	Process
GO:0099641	anterograde axonal protein transport	23728742.	IMP	Process
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	-	ISS	Process
GO:1904115	axon cytoplasm	-	IEA	Component
GO:2001028	positive regulation of endothelial cell chemotaxis	18440775.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.