EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23575475	Translation initiation factor eIF3b expression in human cancer and its role in tumor growth and lung colonization.	Clin Cancer Res	2013 Jun 1	Wang H	doi: 10.1158/1078-0432.CCR-12-3084
30551537	Effects of EIF3B gene downregulation on apoptosis and proliferation of human ovarian cancer SKOV3 and HO-8910 cells.	Biomed Pharmacother	2019 Jan	Wang L	doi: 10.1016/j.biopha.2018.10.027

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr7	2372748	Missense_Mutation	novel	S588Y	0.24
BLCA	chr7	2360806	Missense_Mutation	NA	R199Q	0.33
BLCA	chr7	2364383	Missense_Mutation	novel	E337D	0.04
BLCA	chr7	2380503	3'UTR	novel		0.17
BLCA	chr7	2371839	Silent	rs752645322	V559V	0.37
BLCA	chr7	2364398	Nonsense_Mutation	NA	W342*	0.52
BLCA	chr7	2366546	Missense_Mutation	novel	F437L	0.15
BLCA	chr7	2363662	Nonsense_Mutation	novel	E301*	0.54
BLCA	chr7	2360853	Missense_Mutation	novel	G215R	0.08
BRCA	chr7	2378728	Missense_Mutation	NA	E732Q	0.28
BRCA	chr7	2379165	Missense_Mutation	NA	E755G	0.23
BRCA	chr7	2369511	Silent	NA	F481F	0.29
BRCA	chr7	2366546	Missense_Mutation	NA	F437L	0.17
CESC	chr7	2372782	Silent	NA	K599K	0.12
CESC	chr7	2366535	Missense_Mutation	NA	D434N	0.5
CESC	chr7	2360805	Nonsense_Mutation	novel	R199*	0.23
CESC	chr7	2375406	Missense_Mutation	rs759606657	A636V	0.09
CESC	chr7	2375495	Missense_Mutation	rs370274071	V666I	0.36
CESC	chr7	2380392	3'UTR	rs201303353		0.12
CESC	chr7	2380516	3'UTR	novel		0.63
CESC	chr7	2377062	Missense_Mutation	novel	Q714R	0.26
CESC	chr7	2380318	3'UTR	novel		0.26
COAD	chr7	2377002	Missense_Mutation	novel	N694S	0.19
COAD	chr7	2369664	Missense_Mutation	novel	R532S	0.11
COAD	chr7	2371850	Splice_Site	novel	X563_splice	0.16
COAD	chr7	2379458	Silent	novel	F802F	0.14
COAD	chr7	2360837	Missense_Mutation	novel	K209N	0.23
COAD	chr7	2375396	Missense_Mutation	rs766601514	G633S	0.32
COAD	chr7	2363704	Missense_Mutation	rs772725989	R315C	0.22
COAD	chr7	2377024	Missense_Mutation	novel	Q701H	0.3
COAD	chr7	2379474	Missense_Mutation	novel	I808V	0.17
COAD	chr7	2377055	Missense_Mutation	novel	L712M	0.2
COAD	chr7	2366430	Missense_Mutation	novel	A424V	0.18
COAD	chr7	2379458	Silent	novel	F802F	0.25
COAD	chr7	2379153	Missense_Mutation	rs375864470	R751H	0.24
COAD	chr7	2378740	Missense_Mutation	NA	R736C	0.41
DLBC	chr7	2369470	Splice_Site	novel	X468_splice	0.36
ESCA	chr7	2380212	3'UTR	novel		0.33
ESCA	chr7	2372719	Silent	rs779376781	A578A	0.21
GBM	chr7	2376941	Intron	novel		0.19
GBM	chr7	2364394	Missense_Mutation	novel	R341H	0.17
GBM	chr7	2367034	Silent	NA	I464I	0.38
GBM	chr7	2367016	Silent	novel	D458D	0.08
GBM	chr7	2360758	Missense_Mutation	novel	I183T	0.03
GBM	chr7	2375455	Frame_Shift_Del	novel	Y652*	0.25
GBM	chr7	2372789	Missense_Mutation	NA	L602V	0.31
GBM	chr7	2380330	3'UTR	novel		0.1
HNSC	chr7	2369536	Missense_Mutation	novel	P490A	0.23
HNSC	chr7	2372696	Missense_Mutation	novel	E571K	0.37
HNSC	chr7	2369517	Silent	novel	V483V	0.13
HNSC	chr7	2369518	Missense_Mutation	novel	P484S	0.13
HNSC	chr7	2375498	Missense_Mutation	NA	V667I	0.2
KIRC	chr7	2364513	Missense_Mutation	novel	F381I	0.06
KIRC	chr7	2364449	Silent	NA	L359L	0.24
KIRP	chr7	2369647	Missense_Mutation	novel	C527S	0.21
KIRP	chr7	2375471	Missense_Mutation	rs776923545	E658K	0.29
LGG	chr7	2363751	Silent	novel	E330E	0.56
LGG	chr7	2364393	Missense_Mutation	rs368514580	R341C	0.46
LGG	chr7	2364482	Frame_Shift_Ins	novel	*F371Pfs12**	0.04
LGG	chr7	2364484	Missense_Mutation	novel	F371Y	0.04
LIHC	chr7	2363760	Splice_Region	novel	A333A	0.4
LIHC	chr7	2379157	Silent	novel	T752T	0.03
LIHC	chr7	2366574	Missense_Mutation	NA	S447R	0.09
LUAD	chr7	2366524	Splice_Site	NA	X430_splice	0.23
LUAD	chr7	2375495	Missense_Mutation	novel	V666F	0.27
LUAD	chr7	2379182	Missense_Mutation	novel	R761W	0.24
LUAD	chr7	2367031	Missense_Mutation	novel	K463N	0.18
LUAD	chr7	2377035	Missense_Mutation	NA	R705L	0.26
LUAD	chr7	2369631	Silent	NA	K521K	0.12
LUAD	chr7	2369530	Missense_Mutation	NA	D488H	0.06
LUAD	chr7	2369521	Missense_Mutation	NA	E485K	0.17
LUSC	chr7	2380450	3'UTR	novel		0.39
LUSC	chr7	2380417	3'UTR	novel		0.44
LUSC	chr7	2363079	Silent	rs370385949	T274T	0.08
LUSC	chr7	2366341	Silent	novel	L394L	0.2
MESO	chr7	2380489	3'UTR	rs528347164		0.45
OV	chr7	2360757	Missense_Mutation	novel	I183F	0.05
OV	chr7	2360862	Missense_Mutation	novel	T218P	0.9
OV	chr7	2380393	3'UTR	rs377583925		0.57
OV	chr7	2366410	Silent	novel	G417G	0.04
OV	chr7	2360868	Missense_Mutation	novel	D220Y	0.2
OV	chr7	2364449	Silent	NA	L359L	0.04
OV	chr7	2363705	Missense_Mutation	rs371362324	R315H	0.42
PRAD	chr7	2375468	Missense_Mutation	rs139537965	V657I	0.08
PRAD	chr7	2364465	Missense_Mutation	NA	F365I	0.04
READ	chr7	2376899	Intron	NA		0.3
READ	chr7	2371797	Missense_Mutation	NA	E545D	0.57
SARC	chr7	2376814	Intron	novel		0.24
SKCM	chr7	2366564	Silent	novel	L443L	0.22
SKCM	chr7	2376866	Intron	novel		0.27
SKCM	chr7	2362654	Silent	NA	F234F	0.31
SKCM	chr7	2363101	Missense_Mutation	NA	P282S	0.28
SKCM	chr7	2372738	Missense_Mutation	NA	P585S	0.45
SKCM	chr7	2378740	Missense_Mutation	NA	R736C	0.56
SKCM	chr7	2369669	Missense_Mutation	rs747838544	P534L	0.38
SKCM	chr7	2371803	Silent	novel	F547F	0.24
SKCM	chr7	2375522	Missense_Mutation	NA	H675Y	0.28
SKCM	chr7	2379139	Missense_Mutation	NA	L746F	0.4
SKCM	chr7	2369668	Missense_Mutation	NA	P534S	0.51
SKCM	chr7	2369669	Missense_Mutation	rs747838544	P534L	0.51
SKCM	chr7	2369480	Missense_Mutation	rs768314023	S471F	0.31
SKCM	chr7	2369668	Missense_Mutation	NA	P534S	0.42
SKCM	chr7	2375400	Missense_Mutation	NA	A634V	0.14
SKCM	chr7	2375432	Missense_Mutation	novel	V645I	0.25
SKCM	chr7	2379479	Silent	NA	P809P	0.71
SKCM	chr7	2377009	Silent	novel	K696K	0.47
SKCM	chr7	2364481	Missense_Mutation	novel	R370K	0.41
STAD	chr7	2372741	Missense_Mutation	rs531111348	R586W	0.11
STAD	chr7	2363088	Missense_Mutation	NA	D277E	0.05
STAD	chr7	2364451	Frame_Shift_Del	NA	*G362Efs28**	0.37
STAD	chr7	2379236	Nonsense_Mutation	NA	R779*	0.25
STAD	chr7	2366546	Missense_Mutation	NA	F437L	0.35
STAD	chr7	2374583	Silent	rs762355143	F622F	0.28
STAD	chr7	2375444	Missense_Mutation	rs778618845	A649T	0.32
STAD	chr7	2377075	Splice_Region	NA	K718K	0.14
STAD	chr7	2375430	Missense_Mutation	rs181409131	T644M	0.24
STAD	chr7	2362647	Missense_Mutation	rs778237987	Y232C	0.08
STAD	chr7	2364450	Frame_Shift_Ins	rs764010445	*E363Rfs18**	0.38
STAD	chr7	2366327	Missense_Mutation	NA	T390S	0.21
STAD	chr7	2363704	Missense_Mutation	novel	R315S	0.28
STAD	chr7	2379135	Missense_Mutation	NA	E745G	0.16
STAD	chr7	2366366	Missense_Mutation	novel	A403T	0.2
THCA	chr7	2363067	Splice_Region	novel		0.14
THCA	chr7	2364482	Frame_Shift_Ins	novel	*F371Pfs12**	0.04
UCEC	chr7	2374535	Silent	rs748044149	F606F	0.28
UCEC	chr7	2363647	Missense_Mutation	novel	W296R	0.15
UCEC	chr7	2372776	Silent	rs754459941	N597N	0.12
UCEC	chr7	2363727	Silent	NA	D322D	0.22
UCEC	chr7	2369469	Splice_Region	rs749142613		0.1
UCEC	chr7	2374550	Silent	novel	A611A	0.06
UCEC	chr7	2369611	Missense_Mutation	novel	C515R	0.15
UCEC	chr7	2363117	Missense_Mutation	novel	F287C	0.1
UCEC	chr7	2362758	Missense_Mutation	NA	F269C	0.19
UCEC	chr7	2366425	Missense_Mutation	NA	S422R	0.21
UCEC	chr7	2369625	Nonsense_Mutation	novel	W519*	0.04
UCEC	chr7	2376766	Intron	novel		0.21
UCEC	chr7	2379173	Missense_Mutation	novel	R758W	0.19
UCEC	chr7	2375495	Missense_Mutation	rs370274071	V666I	0.41
UCEC	chr7	2380348	3'UTR	novel		0.23
UCEC	chr7	2374583	Silent	rs762355143	F622F	0.36
UCEC	chr7	2380561	3'UTR	novel		0.12
UCEC	chr7	2362679	Missense_Mutation	rs752665303	A243T	0.52
UCEC	chr7	2363759	Missense_Mutation	novel	A333V	0.38
UCEC	chr7	2379415	Missense_Mutation	novel	D788G	0.42
UCEC	chr7	2375396	Missense_Mutation	rs766601514	G633S	0.08
UCEC	chr7	2366391	Missense_Mutation	rs376326730	T411M	0.36
UCEC	chr7	2378724	Silent	novel	I730I	0.21
UCEC	chr7	2369634	Silent	rs754834085	N522N	0.45
UCEC	chr7	2380542	3'UTR	novel		0.48
UCEC	chr7	2380325	3'UTR	novel		0.61
UCEC	chr7	2363088	Silent	rs145413649	D277D	0.4
UCEC	chr7	2366999	Missense_Mutation	NA	S453P	0.41
UCEC	chr7	2379195	Missense_Mutation	NA	Q765R	0.08
UCEC	chr7	2374583	Silent	rs762355143	F622F	0.16
UCEC	chr7	2366570	Silent	novel	T445T	0.28
UCEC	chr7	2364451	Frame_Shift_Del	NA	*G362Efs28**	0.42
UCEC	chr7	2378691	Missense_Mutation	novel	Q719H	0.16
UCEC	chr7	2372748	Missense_Mutation	NA	S588F	0.47
UCEC	chr7	2369480	Missense_Mutation	NA	S471Y	0.26
UCEC	chr7	2362664	Missense_Mutation	rs561298082	A238T	0.14
UCEC	chr7	2369572	Nonsense_Mutation	novel	Q502*	0.2
UCEC	chr7	2369669	Missense_Mutation	rs747838544	P534L	0.21
UCEC	chr7	2379220	Silent	rs756242706	N773N	0.6
UCEC	chr7	2362745	Missense_Mutation	rs763185237	L265I	0.24
UCEC	chr7	2360765	Silent	NA	S185S	0.39
UCEC	chr7	2369593	Missense_Mutation	novel	L509M	0.34
UCEC	chr7	2374583	Silent	rs762355143	F622F	0.35
UCS	chr7	2355376	Missense_Mutation	novel	S152C	0.19

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.5667	0.24436
BRCA	DEL	0.0991	0.056864
DLBC	AMP	0.3333	0.13215
LGG	DEL	0.0292	0.077684
LUAD	AMP	0.4593	0.17291
OV	DEL	0.3972	3.8574e-27
SKCM	AMP	0.4932	0.00015162
STAD	AMP	0.4354	0.0078915
TGCT	AMP	0.7133	0.019484
THCA	DEL	0	0.27619
UCEC	DEL	0.1132	0.00010851

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0036	Kaplan-Meier Survival Analysis
SARC	0.025	Kaplan-Meier Survival Analysis
MESO	0.0088	Kaplan-Meier Survival Analysis
ACC	0.00028	Kaplan-Meier Survival Analysis
HNSC	0.00042	Kaplan-Meier Survival Analysis
SKCM	0.00051	Kaplan-Meier Survival Analysis
LUSC	0.03	Kaplan-Meier Survival Analysis
BRCA	0.043	Kaplan-Meier Survival Analysis
KIRP	0.026	Kaplan-Meier Survival Analysis
COAD	0.04	Kaplan-Meier Survival Analysis
PCPG	0.023	Kaplan-Meier Survival Analysis
BLCA	0.022	Kaplan-Meier Survival Analysis
KICH	0.008	Kaplan-Meier Survival Analysis
GBM	0.042	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.0045	Kaplan-Meier Survival Analysis
LGG	0.014	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.005	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000106263 (Gene tree)
Gene ID: 8662
Gene Symbol: EIF3B
Alias: PRT1|eIF3b|EIF3S9
Full Name: eukaryotic translation initiation factor 3 subunit B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 26,660 bases
Position: chr7:2,354,086-2,380,745
Accession: 3280
RBP type: canonical RBP
Summary: (Eukaryotic Translation Initiation Factor 3 Subunit B) is a Protein Coding gene. Diseases associated with EIF3B include Hyperinsulinemic Hypoglycemia, Familial, 2. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000407785	RRM_1	PF00076.22	1.3e-07	1	1
ENSP00000354125	RRM_1	PF00076.22	4.1e-07	1	1
ENSP00000380206	RRM_1	PF00076.22	4.1e-07	1	1
ENSP00000354125	eIF2A	PF08662.11	1.9e-71	1	1
ENSP00000380206	eIF2A	PF08662.11	1.9e-71	1	1
ENSP00000408062	eIF2A	PF08662.11	0.00028	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20862284	Crystal structure of the RNA recognition motif of yeast translation initiation factor eIF3b reveals differences to human eIF3b.	PLoS One	2010 Sep 16	Khoshnevis S	doi: 10.1371/journal.pone.0012784.
9362495	Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation.	EMBO J	1997 Nov 17	Verlhac MH	-
7798228	Purified yeast translational initiation factor eIF-3 is an RNA-binding protein complex that contains the PRT1 protein.	J Biol Chem	1994 Dec 23	Naranda T	-
20816988	Distinct regions of human eIF3 are sufficient for binding to the HCV IRES and the 40S ribosomal subunit.	J Mol Biol	2010 Oct 22	Cai Q	doi: 10.1016/j.jmb.2010.07.054
25336651	Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor β1-3 (TGF-β1-3).	J Biol Chem	2014 Dec 5	Yue MM	doi: 10.1074/jbc.M114.609495
24063684	Impaired binding of standard initiation factors eIF3b, eIF4G and eIF4B to domain V of the live-attenuated coxsackievirus B3 Sabin3-like IRES--alternatives for 5'UTR-related cardiovirulence mechanisms.	Diagn Pathol	2013 Sep 24	Souii A	doi: 10.1186/1746-1596-8-161.
25673016	In vitro-reduced translation efficiency of coxsackievirus B3 Sabin3-like strain is correlated to impaired binding of cellular initiation factors to viral IRES RNA.	Curr Microbiol	2015 May	Ben M'hadheb M	doi: 10.1007/s00284-015-0784-z
11179233	Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding.	EMBO J	2001 Feb 15	Valasek L	-
23921387	Spectrin domain of eukaryotic initiation factor 3a is the docking site for formation of the a:b:i:g subcomplex.	J Biol Chem	2013 Sep 27	Dong Z	doi: 10.1074/jbc.M113.483164

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000397011	EIF3B-202	2966	XM_011515600	ENSP00000380206	814 (aa)	XP_011513902	P55884
ENST00000463229	EIF3B-206	552	-	-	- (aa)	-	-
ENST00000431643	EIF3B-204	1074	XM_017012753	ENSP00000408062	153 (aa)	XP_016868242	C9JQN7
ENST00000463026	EIF3B-205	633	-	-	- (aa)	-	-
ENST00000494658	EIF3B-212	637	-	-	- (aa)	-	-
ENST00000466199	EIF3B-208	734	-	-	- (aa)	-	-
ENST00000475415	EIF3B-211	3745	-	-	- (aa)	-	-
ENST00000360876	EIF3B-201	3055	XM_011515599	ENSP00000354125	814 (aa)	XP_011513901	P55884
ENST00000468611	EIF3B-210	1868	-	-	- (aa)	-	-
ENST00000413917	EIF3B-203	962	-	ENSP00000407785	302 (aa)	-	C9JZG1
ENST00000468250	EIF3B-209	602	-	-	- (aa)	-	-
ENST00000465670	EIF3B-207	2766	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000106263's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000106263's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000106263	EIF3B	100	83.660	ENSAPOG00000002297	eif3bb	98	88.404	Acanthochromis_polyacanthus
ENSG00000106263	EIF3B	100	83.660	ENSACIG00000015396	eif3bb	98	88.705	Amphilophus_citrinellus
ENSG00000106263	EIF3B	100	83.660	ENSAOCG00000010921	eif3bb	98	88.554	Amphiprion_ocellaris
ENSG00000106263	EIF3B	100	83.660	ENSAPEG00000000844	eif3bb	98	88.554	Amphiprion_percula
ENSG00000106263	EIF3B	100	83.007	ENSATEG00000008626	eif3bb	98	88.253	Anabas_testudineus
ENSG00000106263	EIF3B	100	93.464	ENSAPLG00000016062	EIF3B	100	94.136	Anas_platyrhynchos
ENSG00000106263	EIF3B	100	92.157	ENSACAG00000008874	-	88	80.197	Anolis_carolinensis
ENSG00000106263	EIF3B	100	100.000	ENSANAG00000020360	EIF3B	100	95.455	Aotus_nancymaae
ENSG00000106263	EIF3B	100	83.007	ENSACLG00000000870	eif3bb	98	87.801	Astatotilapia_calliptera
ENSG00000106263	EIF3B	100	85.621	ENSAMXG00000009773	eif3ba	99	86.156	Astyanax_mexicanus
ENSG00000106263	EIF3B	100	99.346	ENSBTAG00000007474	EIF3B	100	88.575	Bos_taurus
ENSG00000106263	EIF3B	93	41.290	WBGene00001225	eif-3.B	98	34.081	Caenorhabditis_elegans
ENSG00000106263	EIF3B	100	100.000	ENSCJAG00000001442	EIF3B	100	97.174	Callithrix_jacchus
ENSG00000106263	EIF3B	100	98.693	ENSCAFG00000016418	EIF3B	97	89.024	Canis_familiaris
ENSG00000106263	EIF3B	100	98.693	ENSCAFG00020020771	EIF3B	100	86.463	Canis_lupus_dingo
ENSG00000106263	EIF3B	100	99.346	ENSCHIG00000009941	EIF3B	100	88.725	Capra_hircus
ENSG00000106263	EIF3B	100	100.000	ENSTSYG00000008256	EIF3B	99	95.097	Carlito_syrichta
ENSG00000106263	EIF3B	76	98.276	ENSCAPG00000006394	-	99	86.762	Cavia_aperea
ENSG00000106263	EIF3B	86	98.485	ENSCAPG00000009347	-	98	92.130	Cavia_aperea
ENSG00000106263	EIF3B	100	100.000	ENSCPOG00000012541	-	100	89.173	Cavia_porcellus
ENSG00000106263	EIF3B	100	98.039	ENSCPOG00000031410	-	100	88.078	Cavia_porcellus
ENSG00000106263	EIF3B	100	100.000	ENSCCAG00000021556	EIF3B	100	96.806	Cebus_capucinus
ENSG00000106263	EIF3B	100	100.000	ENSCATG00000040107	EIF3B	100	98.894	Cercocebus_atys
ENSG00000106263	EIF3B	100	100.000	ENSCLAG00000006140	EIF3B	100	89.173	Chinchilla_lanigera
ENSG00000106263	EIF3B	100	100.000	ENSCSAG00000017603	EIF3B	100	92.138	Chlorocebus_sabaeus
ENSG00000106263	EIF3B	100	98.693	ENSCHOG00000006142	-	59	98.985	Choloepus_hoffmanni
ENSG00000106263	EIF3B	100	92.157	ENSCPBG00000020654	EIF3B	99	83.439	Chrysemys_picta_bellii
ENSG00000106263	EIF3B	99	63.399	ENSCING00000003620	-	96	60.503	Ciona_intestinalis
ENSG00000106263	EIF3B	65	63.452	ENSCSAVG00000001251	-	90	65.278	Ciona_savignyi
ENSG00000106263	EIF3B	100	100.000	ENSCANG00000042097	EIF3B	100	99.711	Colobus_angolensis_palliatus
ENSG00000106263	EIF3B	100	99.346	ENSCGRG00001019278	Eif3b	100	89.803	Cricetulus_griseus_chok1gshd
ENSG00000106263	EIF3B	100	99.346	ENSCGRG00000004618	Eif3b	100	89.926	Cricetulus_griseus_crigri
ENSG00000106263	EIF3B	100	80.392	ENSCSEG00000020931	eif3bb	98	86.898	Cynoglossus_semilaevis
ENSG00000106263	EIF3B	100	83.660	ENSCVAG00000015650	eif3bb	98	88.253	Cyprinodon_variegatus
ENSG00000106263	EIF3B	100	84.967	ENSDARG00000059654	eif3ba	99	86.451	Danio_rerio
ENSG00000106263	EIF3B	100	82.353	ENSDARG00000074213	eif3bb	99	86.336	Danio_rerio
ENSG00000106263	EIF3B	100	98.693	ENSDNOG00000049572	EIF3B	100	90.424	Dasypus_novemcinctus
ENSG00000106263	EIF3B	100	100.000	ENSDORG00000001401	Eif3b	100	84.908	Dipodomys_ordii
ENSG00000106263	EIF3B	95	43.919	FBgn0034237	eIF3b	97	51.846	Drosophila_melanogaster
ENSG00000106263	EIF3B	100	94.771	ENSETEG00000001719	EIF3B	99	94.393	Echinops_telfairi
ENSG00000106263	EIF3B	100	77.124	ENSEBUG00000004379	eif3bb	99	74.378	Eptatretus_burgeri
ENSG00000106263	EIF3B	100	99.346	ENSEASG00005021167	EIF3B	100	89.793	Equus_asinus_asinus
ENSG00000106263	EIF3B	100	99.346	ENSECAG00000013671	EIF3B	100	90.036	Equus_caballus
ENSG00000106263	EIF3B	100	98.693	ENSEEUG00000014359	EIF3B	88	96.648	Erinaceus_europaeus
ENSG00000106263	EIF3B	100	84.314	ENSELUG00000021762	eif3bb	98	87.743	Esox_lucius
ENSG00000106263	EIF3B	100	99.346	ENSFCAG00000005392	EIF3B	91	94.011	Felis_catus
ENSG00000106263	EIF3B	100	93.464	ENSFALG00000013907	EIF3B	100	88.567	Ficedula_albicollis
ENSG00000106263	EIF3B	100	100.000	ENSFDAG00000007558	EIF3B	97	91.591	Fukomys_damarensis
ENSG00000106263	EIF3B	100	84.314	ENSFHEG00000002563	eif3bb	97	88.404	Fundulus_heteroclitus
ENSG00000106263	EIF3B	100	81.046	ENSGMOG00000006100	eif3bb	98	83.308	Gadus_morhua
ENSG00000106263	EIF3B	100	93.464	ENSGALG00000040999	EIF3B	98	83.042	Gallus_gallus
ENSG00000106263	EIF3B	100	83.660	ENSGACG00000016738	eif3bb	98	86.478	Gasterosteus_aculeatus
ENSG00000106263	EIF3B	100	92.157	ENSGAGG00000003659	EIF3B	97	81.628	Gopherus_agassizii
ENSG00000106263	EIF3B	79	96.914	ENSGGOG00000016291	EIF3B	98	96.914	Gorilla_gorilla
ENSG00000106263	EIF3B	100	83.007	ENSHBUG00000019329	eif3bb	98	87.801	Haplochromis_burtoni
ENSG00000106263	EIF3B	100	99.346	ENSHGLG00000015253	EIF3B	100	88.957	Heterocephalus_glaber_female
ENSG00000106263	EIF3B	100	99.346	ENSHGLG00100015005	EIF3B	89	96.413	Heterocephalus_glaber_male
ENSG00000106263	EIF3B	100	84.314	ENSHCOG00000020583	eif3bb	98	87.688	Hippocampus_comes
ENSG00000106263	EIF3B	100	86.275	ENSIPUG00000018347	eif3b	99	87.187	Ictalurus_punctatus
ENSG00000106263	EIF3B	100	99.346	ENSSTOG00000021545	EIF3B	99	95.828	Ictidomys_tridecemlineatus
ENSG00000106263	EIF3B	100	100.000	ENSJJAG00000014658	Eif3b	100	89.461	Jaculus_jaculus
ENSG00000106263	EIF3B	100	83.007	ENSKMAG00000007432	eif3bb	98	87.349	Kryptolebias_marmoratus
ENSG00000106263	EIF3B	100	84.314	ENSLBEG00000005233	eif3bb	98	88.705	Labrus_bergylta
ENSG00000106263	EIF3B	100	88.889	ENSLACG00000010357	EIF3B	99	90.147	Latimeria_chalumnae
ENSG00000106263	EIF3B	100	88.889	ENSLOCG00000004215	eif3bb	99	89.736	Lepisosteus_oculatus
ENSG00000106263	EIF3B	100	99.346	ENSLAFG00000001540	EIF3B	100	89.193	Loxodonta_africana
ENSG00000106263	EIF3B	100	100.000	ENSMFAG00000046100	EIF3B	100	94.103	Macaca_fascicularis
ENSG00000106263	EIF3B	100	100.000	ENSMMUG00000015529	EIF3B	100	97.683	Macaca_mulatta
ENSG00000106263	EIF3B	100	100.000	ENSMNEG00000042021	EIF3B	100	98.284	Macaca_nemestrina
ENSG00000106263	EIF3B	100	100.000	ENSMLEG00000042295	EIF3B	100	100.000	Mandrillus_leucophaeus
ENSG00000106263	EIF3B	100	83.660	ENSMAMG00000008654	eif3bb	98	88.705	Mastacembelus_armatus
ENSG00000106263	EIF3B	100	83.007	ENSMZEG00005011827	eif3bb	98	87.801	Maylandia_zebra
ENSG00000106263	EIF3B	100	93.464	ENSMGAG00000002719	EIF3B	100	94.136	Meleagris_gallopavo
ENSG00000106263	EIF3B	100	99.346	ENSMAUG00000020259	Eif3b	100	89.435	Mesocricetus_auratus
ENSG00000106263	EIF3B	100	100.000	ENSMICG00000010103	EIF3B	100	94.595	Microcebus_murinus
ENSG00000106263	EIF3B	100	99.346	ENSMOCG00000000390	Eif3b	100	90.172	Microtus_ochrogaster
ENSG00000106263	EIF3B	100	84.314	ENSMMOG00000003655	eif3bb	98	88.705	Mola_mola
ENSG00000106263	EIF3B	100	99.346	ENSMODG00000009778	EIF3B	100	85.154	Monodelphis_domestica
ENSG00000106263	EIF3B	92	82.143	ENSMALG00000002494	eif3bb	99	80.889	Monopterus_albus
ENSG00000106263	EIF3B	100	99.346	MGP_CAROLIEiJ_G0027948	Eif3b	100	97.126	Mus_caroli
ENSG00000106263	EIF3B	100	99.346	ENSMUSG00000056076	Eif3b	99	97.126	Mus_musculus
ENSG00000106263	EIF3B	100	99.346	MGP_PahariEiJ_G0024520	Eif3b	100	97.126	Mus_pahari
ENSG00000106263	EIF3B	100	99.346	MGP_SPRETEiJ_G0028952	Eif3b	100	97.126	Mus_spretus
ENSG00000106263	EIF3B	100	98.693	ENSMPUG00000017919	EIF3B	99	97.866	Mustela_putorius_furo
ENSG00000106263	EIF3B	100	98.039	ENSMLUG00000013740	EIF3B	99	97.923	Myotis_lucifugus
ENSG00000106263	EIF3B	100	100.000	ENSNGAG00000016188	Eif3b	100	89.474	Nannospalax_galili
ENSG00000106263	EIF3B	62	90.511	ENSNBRG00000008582	eif3bb	97	90.511	Neolamprologus_brichardi
ENSG00000106263	EIF3B	100	100.000	ENSNLEG00000008647	EIF3B	100	90.423	Nomascus_leucogenys
ENSG00000106263	EIF3B	100	99.346	ENSMEUG00000000880	EIF3B	77	98.524	Notamacropus_eugenii
ENSG00000106263	EIF3B	100	98.693	ENSOPRG00000014504	EIF3B	99	93.925	Ochotona_princeps
ENSG00000106263	EIF3B	100	100.000	ENSODEG00000012851	EIF3B	98	80.982	Octodon_degus
ENSG00000106263	EIF3B	100	83.007	ENSONIG00000003283	eif3bb	98	88.253	Oreochromis_niloticus
ENSG00000106263	EIF3B	100	99.346	ENSOANG00000004314	EIF3B	99	98.003	Ornithorhynchus_anatinus
ENSG00000106263	EIF3B	100	100.000	ENSOCUG00000010289	EIF3B	100	97.644	Oryctolagus_cuniculus
ENSG00000106263	EIF3B	100	83.660	ENSORLG00000008861	eif3bb	98	87.145	Oryzias_latipes
ENSG00000106263	EIF3B	100	83.660	ENSORLG00020012732	eif3bb	98	87.145	Oryzias_latipes_hni
ENSG00000106263	EIF3B	100	83.660	ENSORLG00015000357	eif3bb	98	87.145	Oryzias_latipes_hsok
ENSG00000106263	EIF3B	100	83.007	ENSOMEG00000017895	eif3bb	97	87.009	Oryzias_melastigma
ENSG00000106263	EIF3B	100	81.788	ENSOGAG00000006319	EIF3B	98	91.609	Otolemur_garnettii
ENSG00000106263	EIF3B	100	99.346	ENSOARG00000005137	EIF3B	99	89.201	Ovis_aries
ENSG00000106263	EIF3B	100	100.000	ENSPPAG00000032833	EIF3B	100	99.858	Pan_paniscus
ENSG00000106263	EIF3B	100	99.346	ENSPPRG00000003071	EIF3B	100	89.403	Panthera_pardus
ENSG00000106263	EIF3B	100	99.346	ENSPTIG00000013328	EIF3B	83	98.920	Panthera_tigris_altaica
ENSG00000106263	EIF3B	100	100.000	ENSPTRG00000046041	-	100	99.263	Pan_troglodytes
ENSG00000106263	EIF3B	100	100.000	ENSPTRG00000018860	EIF3B	100	99.263	Pan_troglodytes
ENSG00000106263	EIF3B	100	100.000	ENSPANG00000014557	EIF3B	100	94.226	Papio_anubis
ENSG00000106263	EIF3B	100	85.621	ENSPKIG00000009981	eif3ba	98	89.628	Paramormyrops_kingsleyae
ENSG00000106263	EIF3B	100	84.967	ENSPKIG00000011735	eif3bb	99	88.183	Paramormyrops_kingsleyae
ENSG00000106263	EIF3B	100	92.157	ENSPSIG00000009889	EIF3B	99	88.122	Pelodiscus_sinensis
ENSG00000106263	EIF3B	100	83.660	ENSPMGG00000016466	eif3bb	99	88.253	Periophthalmus_magnuspinnatus
ENSG00000106263	EIF3B	100	100.000	ENSPEMG00000021554	Eif3b	100	90.172	Peromyscus_maniculatus_bairdii
ENSG00000106263	EIF3B	100	75.974	ENSPMAG00000005331	eif3bb	97	78.080	Petromyzon_marinus
ENSG00000106263	EIF3B	100	99.346	ENSPCIG00000009464	EIF3B	98	98.457	Phascolarctos_cinereus
ENSG00000106263	EIF3B	100	84.314	ENSPFOG00000001449	eif3bb	98	88.855	Poecilia_formosa
ENSG00000106263	EIF3B	100	84.314	ENSPLAG00000005120	eif3bb	98	83.584	Poecilia_latipinna
ENSG00000106263	EIF3B	100	84.314	ENSPMEG00000015157	eif3bb	99	88.855	Poecilia_mexicana
ENSG00000106263	EIF3B	100	84.314	ENSPREG00000006422	eif3bb	98	89.006	Poecilia_reticulata
ENSG00000106263	EIF3B	100	100.000	ENSPPYG00000017313	EIF3B	93	98.146	Pongo_abelii
ENSG00000106263	EIF3B	100	99.346	ENSPCAG00000010455	-	70	99.313	Procavia_capensis
ENSG00000106263	EIF3B	100	100.000	ENSPCOG00000025894	EIF3B	100	94.010	Propithecus_coquereli
ENSG00000106263	EIF3B	100	96.732	ENSPVAG00000013735	EIF3B	92	98.287	Pteropus_vampyrus
ENSG00000106263	EIF3B	100	82.353	ENSPNYG00000014859	eif3bb	97	74.849	Pundamilia_nyererei
ENSG00000106263	EIF3B	100	85.621	ENSPNAG00000021677	eif3ba	99	87.187	Pygocentrus_nattereri
ENSG00000106263	EIF3B	100	99.346	ENSRNOG00000001253	Eif3b	100	90.049	Rattus_norvegicus
ENSG00000106263	EIF3B	100	100.000	ENSRBIG00000030590	EIF3B	100	100.000	Rhinopithecus_bieti
ENSG00000106263	EIF3B	100	100.000	ENSRROG00000035023	EIF3B	100	98.526	Rhinopithecus_roxellana
ENSG00000106263	EIF3B	90	36.129	YOR361C	PRT1	85	31.603	Saccharomyces_cerevisiae
ENSG00000106263	EIF3B	100	100.000	ENSSBOG00000001954	EIF3B	97	97.273	Saimiri_boliviensis_boliviensis
ENSG00000106263	EIF3B	100	99.346	ENSSHAG00000001063	EIF3B	100	85.305	Sarcophilus_harrisii
ENSG00000106263	EIF3B	100	85.621	ENSSFOG00015006390	eif3bb	98	89.790	Scleropages_formosus
ENSG00000106263	EIF3B	100	85.621	ENSSFOG00015005824	eif3ba	98	88.806	Scleropages_formosus
ENSG00000106263	EIF3B	100	84.314	ENSSMAG00000021264	eif3bb	98	86.898	Scophthalmus_maximus
ENSG00000106263	EIF3B	100	83.660	ENSSDUG00000016761	eif3bb	98	88.554	Seriola_dumerili
ENSG00000106263	EIF3B	100	83.660	ENSSLDG00000022874	eif3bb	98	88.404	Seriola_lalandi_dorsalis
ENSG00000106263	EIF3B	100	98.693	ENSSARG00000006036	EIF3B	99	97.975	Sorex_araneus
ENSG00000106263	EIF3B	100	94.771	ENSSPUG00000001870	EIF3B	99	94.136	Sphenodon_punctatus
ENSG00000106263	EIF3B	100	83.660	ENSSPAG00000013403	eif3bb	98	88.554	Stegastes_partitus
ENSG00000106263	EIF3B	100	99.346	ENSSSCG00000039390	EIF3B	100	89.066	Sus_scrofa
ENSG00000106263	EIF3B	100	93.464	ENSTGUG00000008140	EIF3B	100	92.676	Taeniopygia_guttata
ENSG00000106263	EIF3B	100	84.967	ENSTRUG00000011064	eif3bb	98	87.952	Takifugu_rubripes
ENSG00000106263	EIF3B	99	83.444	ENSTNIG00000004648	eif3bb	99	87.237	Tetraodon_nigroviridis
ENSG00000106263	EIF3B	88	100.000	ENSTBEG00000012836	EIF3B	93	83.641	Tupaia_belangeri
ENSG00000106263	EIF3B	99	78.986	ENSTTRG00000014713	EIF3B	92	79.604	Tursiops_truncatus
ENSG00000106263	EIF3B	100	99.346	ENSUAMG00000000800	EIF3B	99	98.018	Ursus_americanus
ENSG00000106263	EIF3B	100	99.346	ENSUMAG00000007200	EIF3B	100	99.049	Ursus_maritimus
ENSG00000106263	EIF3B	100	99.346	ENSVVUG00000004280	EIF3B	100	99.051	Vulpes_vulpes
ENSG00000106263	EIF3B	100	86.928	ENSXETG00000020593	eif3b	99	88.872	Xenopus_tropicalis
ENSG00000106263	EIF3B	100	83.660	ENSXCOG00000008279	eif3bb	98	87.199	Xiphophorus_couchianus
ENSG00000106263	EIF3B	100	83.660	ENSXMAG00000004705	eif3bb	98	87.349	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001732	formation of cytoplasmic translation initiation complex	-	IEA	Process
GO:0003723	RNA binding	25849773.27462815.	IDA	Function
GO:0003743	translation initiation factor activity	21873635.	IBA	Function
GO:0003743	translation initiation factor activity	17322308.18599441.	IC	Function
GO:0003743	translation initiation factor activity	8995410.	IDA	Function
GO:0003743	translation initiation factor activity	17581632.25849773.	IDA	Function
GO:0005515	protein binding	11169732.14688252.15567442.18423201.18599441.18628297.19245811.19615732.21986499.24396066.24423872.30021884.	IPI	Function
GO:0005829	cytosol	-	TAS	Component
GO:0005852	eukaryotic translation initiation factor 3 complex	21873635.	IBA	Component
GO:0005852	eukaryotic translation initiation factor 3 complex	8995410.17322308.17581632.18599441.25849773.	IDA	Component
GO:0006413	translational initiation	21873635.	IBA	Process
GO:0006413	translational initiation	17322308.18599441.	IC	Process
GO:0006413	translational initiation	8995410.17581632.	IDA	Process
GO:0006413	translational initiation	-	TAS	Process
GO:0006446	regulation of translational initiation	8995410.	IDA	Process
GO:0016282	eukaryotic 43S preinitiation complex	-	IEA	Component
GO:0031369	translation initiation factor binding	-	IEA	Function
GO:0033290	eukaryotic 48S preinitiation complex	-	IEA	Component
GO:0045202	synapse	-	IEA	Component
GO:0060090	molecular adaptor activity	17322308.	TAS	Function
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	-	IEA	Component
GO:0075522	IRES-dependent viral translational initiation	9573242.	IDA	Process
GO:0075525	viral translational termination-reinitiation	21347434.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.