EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22532625	Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer.	J Mol Cell Biol	2012 Jun	Choi JW	doi: 10.1093/jmcb/mjs018
22285955	Selective regression of cancer cells expressing a splicing variant of AIMP2 through targeted RNA replacement by trans-splicing ribozyme.	J Biotechnol	2012 Mar 31	Won YS	doi: 10.1016/j.jbiotec.2012.01.006
22562359	Lentiviral vector-mediated shRNA against AIMP2-DX2 suppresses lung cancer cell growth through blocking glucose uptake.	Mol Cells	2012 Jun	Chang SH	doi: 10.1007/s10059-012-2269-2
21483803	Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis.	PLoS Genet	2011 Mar	Choi JW	doi: 10.1371/journal.pgen.1001351
27302160	Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression.	Cancer Res	2016 Aug 15	Oh AY	doi: 10.1158/0008-5472.CAN-15-1025

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr7	6023316	Missense_Mutation	novel	Q196H	0.05
BLCA	chr7	6009283	5'UTR	novel		0.15
BLCA	chr7	6015334	Missense_Mutation	NA	L108F	0.18
BLCA	chr7	6015290	Nonsense_Mutation	novel	Q94*	0.06
BLCA	chr7	6009457	Missense_Mutation	rs200362634	G32C	0.1
BLCA	chr7	6023600	Missense_Mutation	novel	C291F	0.19
BLCA	chr7	6023601	Missense_Mutation	novel	C291W	0.18
BRCA	chr7	6023480	Frame_Shift_Del	NA	*A253Pfs7**	0.4
BRCA	chr7	6015180	Missense_Mutation	NA	S57F	0.12
CESC	chr7	6015251	Missense_Mutation	NA	Q81E	0.26
CESC	chr7	6017863	Missense_Mutation	novel	P131L	0.25
CESC	chr7	6023415	Silent	rs764803060	N229N	0.51
CESC	chr7	6023675	Frame_Shift_Del	novel	*L316Pfs9**	0.11
COAD	chr7	6023580	Silent	NA	V284V	0.18
COAD	chr7	6018013	Missense_Mutation	novel	Y181F	0.25
COAD	chr7	6017901	Nonsense_Mutation	novel	E144*	0.11
COAD	chr7	6009333	5'UTR	novel		0.06
COAD	chr7	6017836	Missense_Mutation	rs764368950	I122T	0.34
COAD	chr7	6017932	Missense_Mutation	rs75895975	T154M	0.16
COAD	chr7	6023307	Silent	rs761471943	P193P	0.13
COAD	chr7	6017854	Missense_Mutation	rs747974072	P128L	0.3
COAD	chr7	6017928	Missense_Mutation	rs764843355	H153Y	0.16
COAD	chr7	6017870	Silent	novel	L133L	0.54
ESCA	chr7	6023336	Missense_Mutation	rs766467029	T203M	0.38
GBM	chr7	6015148	Splice_Region	novel	E46E	0.15
GBM	chr7	6017880	Missense_Mutation	novel	V137L	0.05
GBM	chr7	6015307	Silent	rs538013036	T99T	0.5
GBM	chr7	6023312	Missense_Mutation	novel	T195R	0.05
HNSC	chr7	6017991	Missense_Mutation	novel	K174E	0.43
HNSC	chr7	6023669	Missense_Mutation	rs372238513	T314M	0.15
LGG	chr7	6015228	Missense_Mutation	rs150139402	V73A	0.06
LIHC	chr7	6015259	Silent	novel	P83P	0.32
LUAD	chr7	6023619	Silent	NA	A297A	0.28
LUAD	chr7	6009304	5'UTR	novel		0.3
LUSC	chr7	6009339	5'UTR	novel		0.29
LUSC	chr7	6015217	Missense_Mutation	NA	L69F	0.21
LUSC	chr7	6023295	Splice_Region	novel		0.32
LUSC	chr7	6017938	Missense_Mutation	rs746796665	S156F	0.24
LUSC	chr7	6023416	Missense_Mutation	rs756474990	A230T	0.29
OV	chr7	6017855	Silent	NA	P128P	0.31
READ	chr7	6018006	Missense_Mutation	rs750336358	Q179E	0.76
SKCM	chr7	6009250	5'UTR	novel		0.24
SKCM	chr7	6023376	Missense_Mutation	NA	F216L	0.16
SKCM	chr7	6015173	Missense_Mutation	novel	L55F	0.7
SKCM	chr7	6009250	5'UTR	novel		0.15
SKCM	chr7	6015208	Silent	novel	L66L	0.4
SKCM	chr7	6015240	Missense_Mutation	NA	S77F	0.46
SKCM	chr7	6009281	5'UTR	rs566011847		0.32
STAD	chr7	6023438	Missense_Mutation	novel	V237A	0.19
STAD	chr7	6023678	Missense_Mutation	NA	K317T	0.15
STAD	chr7	6017971	Missense_Mutation	rs771380350	K167R	0.1
STAD	chr7	6023610	Silent	novel	T294T	0.15
STAD	chr7	6023536	Missense_Mutation	rs770771902	A270T	0.33
STAD	chr7	6023436	Nonsense_Mutation	rs779256399	W236*	0.32
STAD	chr7	6023591	Missense_Mutation	NA	I288S	0.35
STAD	chr7	6009385	Missense_Mutation	rs377537932	P8S	0.27
STAD	chr7	6023519	Missense_Mutation	NA	G264V	0.3
THYM	chr7	6023336	Missense_Mutation	rs766467029	T203M	0.3
UCEC	chr7	6015295	Silent	rs746565414	A95A	0.2
UCEC	chr7	6009312	5'UTR	novel		0.32
UCEC	chr7	6017819	Silent	rs747924744	Y116Y	0.49
UCEC	chr7	6023447	Missense_Mutation	rs140208111	A240V	0.41
UCEC	chr7	6023466	Silent	novel	E246E	0.22
UCEC	chr7	6015204	Missense_Mutation	NA	R65H	0.2
UCEC	chr7	6017837	Silent	NA	I122I	0.31
UCEC	chr7	6023411	Missense_Mutation	NA	V228G	0.24
UCEC	chr7	6023428	Missense_Mutation	NA	D234Y	0.25
UCEC	chr7	6023498	Missense_Mutation	novel	R257L	0.1
UCEC	chr7	6017838	Missense_Mutation	novel	V123M	0.59
UCEC	chr7	6023563	Missense_Mutation	rs374123170	V279M	0.39
UCEC	chr7	6009385	Missense_Mutation	NA	P8T	0.73
UCEC	chr7	6015337	Missense_Mutation	novel	N109K	0.39
UCEC	chr7	6015294	Missense_Mutation	rs368845750	A95V	0.35
UCEC	chr7	6023344	Missense_Mutation	novel	P206S	0.34
UCEC	chr7	6018041	Missense_Mutation	novel	K190N	0.26
UCEC	chr7	6023669	Missense_Mutation	rs372238513	T314M	0.35
UCEC	chr7	6018007	Missense_Mutation	novel	Q179R	0.32
UCEC	chr7	6023313	Silent	rs767064905	T195T	0.36
UCEC	chr7	6015195	Missense_Mutation	NA	I62S	0.42
UCEC	chr7	6023356	Missense_Mutation	rs756425703	E210K	0.38
UCEC	chr7	6023408	Missense_Mutation	novel	A227V	0.37
UCEC	chr7	6015203	Missense_Mutation	rs140850823	R65C	0.43
UCS	chr7	6015307	Silent	rs538013036	T99T	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.5667	0.24436
LUAD	AMP	0.4574	0.17291
OV	DEL	0.4041	3.8574e-27
SKCM	AMP	0.5068	0.00015162
STAD	AMP	0.4422	0.0078915
TGCT	AMP	0.72	0.019484
THCA	DEL	0	0.27619

Survival Analysis

Cancer	P-value	Q-value
MESO	0.006	Kaplan-Meier Survival Analysis
ACC	0.002	Kaplan-Meier Survival Analysis
HNSC	0.00013	Kaplan-Meier Survival Analysis
SKCM	0.0018	Kaplan-Meier Survival Analysis
BRCA	0.011	Kaplan-Meier Survival Analysis
ESCA	0.025	Kaplan-Meier Survival Analysis
BLCA	0.00048	Kaplan-Meier Survival Analysis
CESC	0.012	Kaplan-Meier Survival Analysis
KICH	0.0086	Kaplan-Meier Survival Analysis
UCEC	0.031	Kaplan-Meier Survival Analysis
LUAD	0.014	Kaplan-Meier Survival Analysis
UVM	0.014	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000106305 (Gene tree)
Gene ID: 7965
Gene Symbol: AIMP2
Alias: p38|PRO0992|JTV-1|JTV1
Full Name: aminoacyl tRNA synthetase complex interacting multifunctional protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 14,590 bases
Position: chr7:6,009,245-6,023,834
Accession: 20609
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19648294	p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.	Hum Mol Genet	2009 Nov 1	Farooq F	doi: 10.1093/hmg/ddp352
23575223	Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeutics.	Hum Mol Genet	2013 Aug 1	Amirouche A	doi: 10.1093/hmg/ddt165
26494902	Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic muscles.	Hum Mol Genet	2016 Jan 1	Peladeau C	doi: 10.1093/hmg/ddv444

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000395236	AIMP2-202	860	-	ENSP00000378658	251 (aa)	-	F8W950
ENST00000223029	AIMP2-201	1225	-	ENSP00000223029	320 (aa)	-	Q13155
ENST00000415999	AIMP2-204	777	-	ENSP00000392519	48 (aa)	-	F8WCL2
ENST00000400479	AIMP2-203	1107	XM_005249847	ENSP00000383327	242 (aa)	XP_005249904	A8MU58

Gene Model

Click here to download ENSG00000106305's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000106305	rs34097030	7	6014758	A	Reticulocyte fraction of red cells	27863252	[0.021-0.038] unit decrease	0.02982401	EFO_0007986

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000106305's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	16189514.18695251.19060904.21044950.21285945.21516116.21536907.21900206.21988832.22190034.23159739.24212136.24312579.25416956.26496610.26871637.27107012.29997244.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	19289464.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0008285	negative regulation of cell proliferation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	19131329.	IDA	Component
GO:0031398	positive regulation of protein ubiquitination	-	IEA	Process
GO:0060090	molecular adaptor activity	-	IEA	Function
GO:0060510	type II pneumocyte differentiation	-	IEA	Process
GO:0065003	protein-containing complex assembly	-	IEA	Process
GO:1901216	positive regulation of neuron death	-	IEA	Process
GO:1903632	positive regulation of aminoacyl-tRNA ligase activity	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.