EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27034171	Rheb may complex with RASSF1A to coordinate Hippo and TOR signaling.	Oncotarget	2016 Jun 7	Nelson N	doi: 10.18632/oncotarget.8447.
26255626	Point mutations of the mTOR-RHEB pathway in renal cell carcinoma.	Oncotarget	2015 Jul 20	Ghosh AP	-
18650380	ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo.	Proc Natl Acad Sci U S A	2008 Jul 29	Schewe DM	doi: 10.1073/pnas.0800939105
18708577	Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.	Genes Dev	2008 Aug 15	Nardella C	doi: 10.1101/gad.1699608.
20554106	Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells.	Cancer Lett	2010 Nov 1	Zheng H	doi: 10.1016/j.canlet.2010.05.004.
26319900	Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells.	Cancer Lett	2015 Dec 1	Altman MK	doi: 10.1016/j.canlet.2015.08.012
25594310	Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy.	Mol Carcinog	2016 Feb	Campos T	doi: 10.1002/mc.22272
20127734	Regulation of androgen receptor transactivity and mTOR-S6 kinase pathway by Rheb in prostate cancer cell proliferation.	Prostate	2010 Jun 1	Kobayashi T	doi: 10.1002/pros.21120.
27013580	Fas-associated protein with death domain (FADD) regulates autophagy through promoting the expression of Ras homolog enriched in brain (Rheb) in human breast adenocarcinoma cells.	Oncotarget	2016 Apr 26	He L	doi: 10.18632/oncotarget.8249.
29996312	[Polymorphisms of mTORC1 genes and risk of primary colorectal adenocarcinoma in Chinese populations].	Zhonghua Bing Li Xue Za Zhi	2018 Jul 8	Yu L	doi: 10.3760/cma.j.issn.0529-5807.2018.07.003.
29320991	An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation.	BMC Cancer	2018 Jan 10	Heard JJ	doi: 10.1186/s12885-017-3938-5.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr7	151484760	Nonsense_Mutation	NA	Q57*	0.39	MMR_HSR1
BLCA	chr7	151484778	Missense_Mutation	novel	G51R	0.09	MMR_HSR1
BRCA	chr7	151490982	Missense_Mutation	NA	G29S	0.22	MMR_HSR1
COAD	chr7	151490999	Missense_Mutation	NA	T23M	0.32	MMR_HSR1
COAD	chr7	151467161	Silent	rs143352740	D171D	0.38
COAD	chr7	151484804	Missense_Mutation	NA	T42I	0.3	MMR_HSR1
GBM	chr7	151467193	Nonsense_Mutation	novel	R161*	0.24
HNSC	chr7	151470611	Nonsense_Mutation	novel	W141*	0.31
KIRC	chr7	151471368	Intron	NA		0.45
KIRC	chr7	151490964	Missense_Mutation	NA	Y35N	0.19	MMR_HSR1
KIRC	chr7	151484783	Missense_Mutation	NA	V49E	0.15	MMR_HSR1
KIRP	chr7	151490964	Missense_Mutation	NA	Y35N	0.06	MMR_HSR1
LIHC	chr7	151490963	Missense_Mutation	NA	Y35C	0.05	MMR_HSR1
LUAD	chr7	151470649	Silent	novel	V128V	0.16
LUAD	chr7	151467145	Missense_Mutation	NA	G177C	0.12
LUAD	chr7	151490999	Missense_Mutation	NA	T23M	0.09	MMR_HSR1
LUAD	chr7	151477415	Missense_Mutation	novel	D65H	0.24	MMR_HSR1
LUAD	chr7	151477416	Splice_Site	novel	X65_splice	0.24
LUSC	chr7	151484742	Missense_Mutation	NA	G63W	0.3	MMR_HSR1
LUSC	chr7	151484750	Missense_Mutation	novel	D60V	0.36	MMR_HSR1
LUSC	chr7	151477408	Missense_Mutation	novel	Y67F	0.09	MMR_HSR1
OV	chr7	151484770	Missense_Mutation	NA	E53D	0.16	MMR_HSR1
OV	chr7	151490962	Nonsense_Mutation	novel	Y35*	0.04	MMR_HSR1
READ	chr7	151467009	3'UTR	novel		0.52
READ	chr7	151470650	Missense_Mutation	novel	V128E	0.15
SKCM	chr7	151471571	Silent	NA	L104L	0.27
SKCM	chr7	151470622	Missense_Mutation	NA	L137F	0.07
SKCM	chr7	151519474	Missense_Mutation	novel	G13D	0.56	MMR_HSR1
SKCM	chr7	151519475	Missense_Mutation	novel	G13S	0.5	MMR_HSR1
STAD	chr7	151467120	Nonstop_Mutation	novel	185Lext6	0.34
STAD	chr7	151467161	Silent	rs143352740	D171D	0.31
STAD	chr7	151484756	Missense_Mutation	NA	L58R	0.23	MMR_HSR1
TGCT	chr7	151490962	Nonsense_Mutation	novel	Y35*	0.04	MMR_HSR1
UCEC	chr7	151490997	Missense_Mutation	NA	I24V	0.04	MMR_HSR1
UCEC	chr7	151470624	Silent	novel	L137L	0.04
UCEC	chr7	151490999	Missense_Mutation	NA	T23M	0.2	MMR_HSR1
UCEC	chr7	151470579	Nonsense_Mutation	novel	E152*	0.31
UCEC	chr7	151470631	Silent	novel	G134G	0.56
UCEC	chr7	151490993	Missense_Mutation	NA	Q25R	0.42	MMR_HSR1
UCEC	chr7	151477389	Silent	novel	T73T	0.33
UCEC	chr7	151490989	Missense_Mutation	novel	F26L	0.28	MMR_HSR1
UCEC	chr7	151490964	Missense_Mutation	NA	Y35N	0.46	MMR_HSR1
UCEC	chr7	151477368	Silent	novel	G80G	0.1
UCEC	chr7	151467009	3'UTR	novel		0.58
UCEC	chr7	151470584	Missense_Mutation	novel	A150V	0.46
UCEC	chr7	151477413	Splice_Region	novel	D65D	0.47
UCEC	chr7	151484804	Missense_Mutation	NA	T42N	0.23	MMR_HSR1
UCEC	chr7	151467060	3'UTR	novel		0.47
UCEC	chr7	151467161	Silent	rs143352740	D171D	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0778	0.12261
CESC	DEL	0.1797	0.0016147
DLBC	DEL	0.0833	0.03486
HNSC	DEL	0.2088	1.1399e-22
KIRC	AMP	0.2898	0.075418
LAML	DEL	0.1309	3.4101e-05
LGG	AMP	0.3119	1.5525e-07
LIHC	DEL	0.0757	0.24831
OV	AMP	0.4853	1.5763e-13
PAAD	DEL	0.0652	0.049388
TGCT	DEL	0.0733	0.11738
THCA	DEL	0	0.27619
UCEC	DEL	0.0983	0.0001859
UCS	DEL	0.3036	0.10142

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0021	Kaplan-Meier Survival Analysis
MESO	0.0025	Kaplan-Meier Survival Analysis
ACC	0.0082	Kaplan-Meier Survival Analysis
HNSC	0.0094	Kaplan-Meier Survival Analysis
PRAD	0.04	Kaplan-Meier Survival Analysis
BRCA	0.036	Kaplan-Meier Survival Analysis
KIRP	0.00064	Kaplan-Meier Survival Analysis
PAAD	0.012	Kaplan-Meier Survival Analysis
LAML	0.042	Kaplan-Meier Survival Analysis
KICH	0.035	Kaplan-Meier Survival Analysis
LIHC	0.00014	Kaplan-Meier Survival Analysis
LGG	0.00078	Kaplan-Meier Survival Analysis
UVM	0.0037	Kaplan-Meier Survival Analysis
OV	0.044	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000106615 (Gene tree)
Gene ID: 6009
Gene Symbol: RHEB
Alias: RHEB2
Full Name: Ras homolog, mTORC1 binding
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 54,109 bases
Position: chr7:151,466,012-151,520,120
Accession: 10011
RBP type: canonical RBP
Summary: This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000262187	MMR_HSR1	PF01926.23	0.00019	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18842593	Rheb and mTOR regulate neuronal polarity through Rap1B.	J Biol Chem	2008 Nov 28	Li YH	doi: 10.1074/jbc.M802431200

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000478470	RHEB-205	1153	-	ENSP00000417802	47 (aa)	-	F8WBL3
ENST00000470370	RHEB-203	501	-	ENSP00000417212	19 (aa)	-	C9J469
ENST00000482053	RHEB-206	557	-	-	- (aa)	-	-
ENST00000262187	RHEB-201	2075	XM_011516457	ENSP00000262187	184 (aa)	XP_011514759	Q15382
ENST00000496004	RHEB-207	744	-	ENSP00000418161	79 (aa)	-	C9J931
ENST00000470072	RHEB-202	764	-	-	- (aa)	-	-
ENST00000472642	RHEB-204	900	-	ENSP00000420726	79 (aa)	-	C9J931

Gene Model

Click here to download ENSG00000106615's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04072	Phospholipase D signaling pathway	KEGG
hsa04140	Autophagy - animal	KEGG
hsa04150	mTOR signaling pathway	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04152	AMPK signaling pathway	KEGG
hsa04211	Longevity regulating pathway	KEGG
hsa04218	Cellular senescence	KEGG
hsa04714	Thermogenesis	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05165	Human papillomavirus infection	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG
hsa05231	Choline metabolism in cancer	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000106615	rs17635967	7	151487834	?	Carboplatin disposition in epthelial ovarian cancer	29367611	unit decrease (EA)	1.49	Orphanet_398934\|GO_0097328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000106615's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000106615	RHEB	100	100.000	ENSANAG00000022525	RHEB	100	99.457	Aotus_nancymaae
ENSG00000106615	RHEB	100	100.000	ENSBTAG00000031861	RHEB	100	99.457	Bos_taurus
ENSG00000106615	RHEB	100	100.000	ENSCJAG00000042669	RHEB	100	99.457	Callithrix_jacchus
ENSG00000106615	RHEB	100	100.000	ENSCAFG00000004894	RHEB	100	99.457	Canis_familiaris
ENSG00000106615	RHEB	100	100.000	ENSCAFG00020005505	RHEB	100	99.457	Canis_lupus_dingo
ENSG00000106615	RHEB	100	100.000	ENSCHIG00000017350	RHEB	100	99.457	Capra_hircus
ENSG00000106615	RHEB	100	89.189	ENSTSYG00000027100	-	100	89.189	Carlito_syrichta
ENSG00000106615	RHEB	100	100.000	ENSTSYG00000034760	-	94	96.045	Carlito_syrichta
ENSG00000106615	RHEB	100	100.000	ENSCPOG00000031743	RHEB	100	100.000	Cavia_porcellus
ENSG00000106615	RHEB	100	100.000	ENSCCAG00000030751	RHEB	100	99.457	Cebus_capucinus
ENSG00000106615	RHEB	100	100.000	ENSCATG00000036856	RHEB	100	100.000	Cercocebus_atys
ENSG00000106615	RHEB	100	100.000	ENSCPBG00000018286	RHEB	100	98.913	Chrysemys_picta_bellii
ENSG00000106615	RHEB	100	100.000	ENSCGRG00001021366	Rheb	100	98.913	Cricetulus_griseus_chok1gshd
ENSG00000106615	RHEB	100	100.000	ENSEASG00005001996	RHEB	100	99.457	Equus_asinus_asinus
ENSG00000106615	RHEB	100	100.000	ENSECAG00000010046	RHEB	100	99.457	Equus_caballus
ENSG00000106615	RHEB	100	100.000	ENSFCAG00000012862	RHEB	100	99.457	Felis_catus
ENSG00000106615	RHEB	100	100.000	ENSFDAG00000020602	RHEB	100	99.457	Fukomys_damarensis
ENSG00000106615	RHEB	100	100.000	ENSGALG00000039880	RHEB	100	98.370	Gallus_gallus
ENSG00000106615	RHEB	63	91.379	ENSGAGG00000022981	-	67	91.379	Gopherus_agassizii
ENSG00000106615	RHEB	100	100.000	ENSGGOG00000014675	RHEB	100	100.000	Gorilla_gorilla
ENSG00000106615	RHEB	100	100.000	ENSHGLG00000006790	RHEB	100	99.457	Heterocephalus_glaber_female
ENSG00000106615	RHEB	100	100.000	ENSSTOG00000004544	RHEB	100	99.457	Ictidomys_tridecemlineatus
ENSG00000106615	RHEB	100	100.000	ENSLAFG00000000691	RHEB	100	99.457	Loxodonta_africana
ENSG00000106615	RHEB	100	100.000	ENSMFAG00000035424	RHEB	100	100.000	Macaca_fascicularis
ENSG00000106615	RHEB	100	100.000	ENSMNEG00000042255	RHEB	100	100.000	Macaca_nemestrina
ENSG00000106615	RHEB	100	100.000	ENSMICG00000033790	RHEB	99	98.089	Microcebus_murinus
ENSG00000106615	RHEB	100	100.000	ENSMOCG00000022240	Rheb	100	98.913	Microtus_ochrogaster
ENSG00000106615	RHEB	100	100.000	MGP_CAROLIEiJ_G0027024	Rheb	100	98.913	Mus_caroli
ENSG00000106615	RHEB	100	100.000	ENSMUSG00000028945	Rheb	100	98.913	Mus_musculus
ENSG00000106615	RHEB	100	100.000	MGP_PahariEiJ_G0021797	Rheb	100	98.913	Mus_pahari
ENSG00000106615	RHEB	100	100.000	MGP_SPRETEiJ_G0028020	Rheb	100	98.913	Mus_spretus
ENSG00000106615	RHEB	100	100.000	ENSNGAG00000023353	Rheb	100	98.913	Nannospalax_galili
ENSG00000106615	RHEB	100	100.000	ENSNLEG00000004500	RHEB	100	100.000	Nomascus_leucogenys
ENSG00000106615	RHEB	100	100.000	ENSMEUG00000011774	-	100	99.206	Notamacropus_eugenii
ENSG00000106615	RHEB	100	100.000	ENSOPRG00000005358	RHEB	100	99.457	Ochotona_princeps
ENSG00000106615	RHEB	100	100.000	ENSODEG00000009963	RHEB	100	100.000	Octodon_degus
ENSG00000106615	RHEB	100	100.000	ENSOCUG00000013173	RHEB	100	99.457	Oryctolagus_cuniculus
ENSG00000106615	RHEB	100	100.000	ENSPPAG00000031857	-	100	99.457	Pan_paniscus
ENSG00000106615	RHEB	100	100.000	ENSPPRG00000018707	RHEB	100	99.457	Panthera_pardus
ENSG00000106615	RHEB	100	91.848	ENSPTRG00000047231	-	100	91.848	Pan_troglodytes
ENSG00000106615	RHEB	100	100.000	ENSPTRG00000046866	RHEB	100	100.000	Pan_troglodytes
ENSG00000106615	RHEB	100	100.000	ENSPANG00000000819	RHEB	100	100.000	Papio_anubis
ENSG00000106615	RHEB	100	100.000	ENSPSIG00000010115	RHEB	100	97.826	Pelodiscus_sinensis
ENSG00000106615	RHEB	100	100.000	ENSPCIG00000003392	RHEB	91	100.000	Phascolarctos_cinereus
ENSG00000106615	RHEB	96	64.205	ENSPLAG00000016748	RHEB	93	64.205	Poecilia_latipinna
ENSG00000106615	RHEB	96	61.932	ENSPMEG00000001179	-	92	61.932	Poecilia_mexicana
ENSG00000106615	RHEB	100	100.000	ENSPCOG00000015977	RHEB	100	99.457	Propithecus_coquereli
ENSG00000106615	RHEB	100	100.000	ENSRNOG00000050578	Rheb	100	98.370	Rattus_norvegicus
ENSG00000106615	RHEB	100	100.000	ENSSPUG00000018361	RHEB	91	98.089	Sphenodon_punctatus
ENSG00000106615	RHEB	100	100.000	ENSSSCG00000016434	RHEB	100	99.457	Sus_scrofa

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0000287	magnesium ion binding	15728574.	IMP	Function
GO:0003924	GTPase activity	-	TAS	Function
GO:0005515	protein binding	17301792.18550814.	IPI	Function
GO:0005525	GTP binding	15728574.	IMP	Function
GO:0005525	GTP binding	-	ISS	Function
GO:0005681	spliceosomal complex	-	IEA	Component
GO:0005765	lysosomal membrane	-	TAS	Component
GO:0005789	endoplasmic reticulum membrane	-	IEA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0007050	cell cycle arrest	-	TAS	Process
GO:0007165	signal transduction	-	IEA	Process
GO:0014069	postsynaptic density	27898073.	EXP	Component
GO:0014069	postsynaptic density	27898073.	IDA	Component
GO:0016020	membrane	8206940.	TAS	Component
GO:0016241	regulation of macroautophagy	-	TAS	Process
GO:0019003	GDP binding	15728574.	IMP	Function
GO:0019901	protein kinase binding	-	IEA	Function
GO:0032008	positive regulation of TOR signaling	20381137.	IMP	Process
GO:0048714	positive regulation of oligodendrocyte differentiation	-	IEA	Process
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component
GO:0120163	negative regulation of cold-induced thermogenesis	28242620.	ISS	Process
GO:2000074	regulation of type B pancreatic cell development	19258434.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.