EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
21187441Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis of Sendai virus.J Immunol2011 Feb 1Okano Sdoi: 10.4049/jimmunol.0901641
24360797Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma.Cancer Cell2014 Jan 13Hou Jdoi: 10.1016/j.ccr.2013.11.011
26910120microRNA-34a-Upregulated Retinoic Acid-Inducible Gene-I Promotes Apoptosis and Delays Cell Cycle Transition in Cervical Cancer Cells.DNA Cell Biol2016 JunWang JHdoi: 10.1089/dna.2015.3130
26336994Anti-angiogenic efficacy of 5'-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs.Oncotarget2015 Oct 6Yuan Ddoi: 10.18632/oncotarget.4869.
28057020RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.J Exp Clin Cancer Res2017 Jan 5Zhu Hdoi: 10.1186/s13046-016-0471-3.
28940253The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer.J Pathol2018 JanShu XSdoi: 10.1002/path.4986
29496994Fascin1 suppresses RIG-I-like receptor signaling and interferon-β production by associating with I??B kinase (IKK) in colon cancer.J Biol Chem2018 Apr 27Matsumura Tdoi: 10.1074/jbc.M117.819201

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr932457145Missense_MutationnovelD919N0.18
BLCAchr932467824Missense_MutationnovelQ708L0.08
BLCAchr932500811Missense_MutationNAH79Y0.05
BLCAchr932489412Missense_MutationnovelR244K0.52
BLCAchr932488169Missense_MutationnovelE330Q0.13ResIII
BLCAchr932485208Missense_MutationnovelE483Q0.4
BLCAchr932492518Missense_MutationnovelM148I0.22
BLCAchr932457123Nonstop_Mutationnovel*926Sext*330.28
BLCAchr932487492Frame_Shift_DelnovelQ451Lfs*240.12
BRCAchr932487533Missense_MutationNAV438A0.2
BRCAchr932459496Missense_MutationNAH786Y0.38
BRCAchr932491386SilentNAD202D0.23
BRCAchr932492526Missense_MutationnovelK146Q0.07
BRCAchr932457351Missense_MutationnovelP850Q0.1
CESCchr932526104Missense_MutationnovelD21E0.19
CESCchr932473039Frame_Shift_DelnovelP651Lfs*60.09
CESCchr932485208Missense_MutationNAE483K0.36
CESCchr932480240Frame_Shift_InsnovelD585*0.09
CESCchr932488110Missense_MutationnovelQ349H0.28ResIII
CESCchr932481409Missense_MutationnovelF523L0.37
COADchr932481342Missense_Mutationrs377702259R546W0.4
COADchr932466438Missense_MutationNAR730T0.12
COADchr932526103Missense_MutationnovelP22S0.3
COADchr932457381Missense_MutationnovelE840G0.05
COADchr932500898Missense_MutationnovelP50T0.23
COADchr932457303Missense_Mutationrs751722546R866Q0.17
COADchr932459431Frame_Shift_DelnovelK807Nfs*170.09
COADchr932492510Missense_MutationnovelG151D0.06
COADchr932493803SilentnovelL127L0.15
COADchr932481338Splice_SitenovelX546_splice0.23
COADchr932491322Missense_MutationNAE224K0.12
COADchr9324570583'UTRnovel0.35
COADchr932488835Frame_Shift_DelNAK284Nfs*630.23ResIII
COADchr932488081Missense_Mutationrs759405155T359M0.36ResIII
COADchr932457202Missense_MutationNAG900R0.1
COADchr932457188SilentnovelL904L0.13
COADchr932473006In_Frame_DelnovelP658_L661del0.33
COADchr932480270Nonsense_Mutationrs371404578R575*0.38
COADchr932480256Silentrs116612738F579F0.17
COADchr932489412Missense_Mutationrs143106649R244I0.18
COADchr932467875Missense_MutationnovelH691R0.07
COADchr932457322Missense_MutationnovelA860T0.31
COADchr932459464Frame_Shift_DelnovelK796Nfs*280.2
ESCAchr932459472Nonsense_Mutationrs760856237Q794*0.77
GBMchr932489367Missense_MutationnovelN259T0.17ResIII
GBMchr9325262435'UTRnovel0.38
GBMchr932488740Missense_MutationnovelR316K0.06ResIII
GBMchr932492503Missense_MutationnovelE153D0.2
GBMchr932457234Missense_Mutationrs191688102I889T0.44
GBMchr932457163Frame_Shift_InsnovelF913Lfs*20.07
HNSCchr932493897Missense_MutationnovelK96T0.78
HNSCchr932488814SilentnovelG291G0.24
HNSCchr932472996Missense_MutationnovelG665S0.17
HNSCchr932493815SilentnovelI123I0.51
HNSCchr932500914Missense_MutationnovelE44D0.07
KIRCchr9324570923'UTRnovel0.17
KIRCchr932488011Silentrs151092988P382P0.49
KIRCchr932480248Missense_MutationNAI582N0.2
KIRPchr932467855Frame_Shift_DelnovelI693Qfs*270.4
KIRPchr932466291Frame_Shift_DelnovelK779Rfs*450.39
KIRPchr932488731Splice_Regionrs5330705250.38
KIRPchr932459422Nonsense_MutationNAC810*0.08
KIRPchr932467859Silentrs767862296A696A0.45
LIHCchr932457128SilentnovelS924S0.21
LIHCchr932489380Missense_MutationNAM255V0.13ResIII
LUADchr932487953SilentNAL402L0.34
LUADchr932466355Missense_MutationNAE758Q0.05
LUADchr932488880SilentnovelG269G0.25
LUADchr932481384Missense_MutationnovelS532C0.74
LUADchr932500930Missense_MutationNAQ39L0.18
LUADchr932480283SilentNAF570F0.11
LUADchr932500902Missense_MutationnovelK48N0.13
LUADchr932492482SilentNAL160L0.19
LUSCchr932459402Missense_MutationnovelA817V0.04
LUSCchr932493810Missense_MutationnovelS125F0.4
LUSCchr932477064SilentnovelL614L0.34
LUSCchr932491367Missense_MutationnovelI209V0.43
LUSCchr932488095Missense_MutationNAN354K0.23ResIII
LUSCchr932488840Nonsense_MutationnovelK283*0.31ResIII
LUSCchr932489367Frame_Shift_DelnovelN259Tfs*30.06ResIII
LUSCchr932500849Missense_MutationnovelE66V0.89
LUSCchr932526091Missense_MutationNAL26M0.17
LUSCchr932487627Missense_MutationnovelG407W0.26ResIII
OVchr932488766In_Frame_DelnovelV293_K307del0.07ResIII
OVchr932487986Missense_MutationNAL391V0.35ResIII
OVchr932485259Missense_Mutationrs769162572R466W0.5
OVchr932493811Missense_MutationNAS125P0.35
OVchr932488119Missense_MutationnovelL346F0.29ResIII
OVchr932457406Missense_Mutationrs567033543T832A0.13
PAADchr932488123Missense_MutationnovelI345T0.23ResIII
PRADchr932457355Missense_MutationnovelK849E0.25
PRADchr932466307Missense_MutationnovelA774S0.38
PRADchr932488834Frame_Shift_InsnovelF285Ifs*200.41ResIII
PRADchr932491394Missense_MutationnovelL200F0.32
READchr932493916Missense_MutationNAE90K0.25
READchr932466355Nonsense_Mutationrs553716308E758*0.34
READchr932480317Missense_MutationnovelR559Q0.06
READchr932493820Missense_Mutationrs749687427D122N0.41
SARCchr932500872SilentnovelL58L0.17
SKCMchr932500836SilentNAF70F0.6
SKCMchr932500847Missense_MutationNAE67K0.41
SKCMchr932500877Missense_MutationnovelF57L0.13
SKCMchr932493805SilentNAL127L0.14
SKCMchr932500836SilentNAF70F0.36
SKCMchr932487518Missense_MutationNAK443R0.08
SKCMchr932477027Missense_MutationNAE627K0.2
SKCMchr9324570283'UTRnovel0.53
STADchr9324570043'UTRnovel0.47
STADchr932493806Missense_MutationnovelD126E0.1
STADchr932487539Missense_Mutationrs139635230A436V0.33
STADchr932492460Missense_Mutationrs757063794P168S0.06
STADchr932488857Missense_MutationNAI277R0.6ResIII
STADchr932481368Missense_MutationNAA537V0.2
STADchr9324570293'UTRnovel0.46
STADchr932481359Frame_Shift_DelnovelL540Yfs*210.4
STADchr932459464Frame_Shift_DelnovelK796Nfs*280.41
STADchr932488797Missense_Mutationrs765663574A297V0.18ResIII
STADchr932492513Missense_MutationnovelA150V0.07
STADchr932457365SilentnovelR845R0.33
STADchr932457296Missense_MutationNAN868K0.09
STADchr932487521Missense_MutationnovelV442A0.33
STADchr932487590Frame_Shift_DelnovelN419Tfs*200.24
STADchr932467895SilentnovelA684A0.08
STADchr9324570173'UTRnovel0.12
STADchr932485237Missense_MutationNAY473C0.23
STADchr932526166Translation_Start_SiteNAM1?0.39
THCAchr932457324Missense_Mutationrs754726367R859K0.15
THYMchr932477117Missense_MutationnovelL597I0.09
UCECchr932459431Frame_Shift_DelnovelK807Nfs*170.52
UCECchr932493803SilentNAL127L0.31
UCECchr932493847Nonsense_MutationNAE113*0.23
UCECchr932459489Missense_MutationNAK788T0.27
UCECchr932466347Missense_MutationNAM760I0.26
UCECchr932488819Missense_MutationnovelK290Q0.16ResIII
UCECchr932457125Missense_MutationnovelK925N0.18
UCECchr932459493Missense_MutationnovelE787K0.11
UCECchr932488076Missense_MutationNAP361S0.4ResIII
UCECchr932498316Intronnovel0.16
UCECchr932481342Missense_Mutationrs377702259R546W0.07
UCECchr932489412Missense_Mutationrs143106649R244I0.45
UCECchr932491327Missense_MutationNAL222R0.4
UCECchr932459456Missense_MutationnovelP799H0.35
UCECchr932457182Silentrs751820024S906S0.37
UCECchr932487538Silentrs146824214A436A0.49
UCECchr932457285Missense_MutationnovelD872G0.19
UCECchr932488889Splice_SiteNAX267_splice0.16
UCECchr932491422Splice_SiteNAX191_splice0.21
UCECchr932493847Nonsense_MutationNAE113*0.21
UCECchr932467919Silentrs772210224P676P0.1
UCECchr932500828Frame_Shift_DelnovelE67Vfs*50.32
UCECchr9324570143'UTRnovel0.26
UCECchr932487979Missense_MutationnovelQ393L0.34ResIII
UCECchr932457155Missense_MutationnovelK915N0.5
UCECchr932467811SilentNAV712V0.4
UCECchr9324570893'UTRnovel0.22
UCECchr932477114Nonsense_MutationnovelE598*0.48
UCECchr932457409Missense_MutationnovelY831H0.13
UCECchr932489427Missense_MutationnovelS239N0.21
UCECchr9324570383'UTRrs5715466840.51
UCECchr932473013Missense_MutationnovelG659D0.48
UCECchr932487539Missense_Mutationrs139635230A436V0.42
UCECchr932480297Missense_MutationnovelY566H0.5
UCECchr9324570013'UTRnovel0.4
UCECchr932466340Missense_MutationnovelD763Y0.09
UCECchr932488121Missense_MutationnovelL346V0.14ResIII
UCECchr932493810Missense_MutationnovelS125F0.15
UCECchr932481380Missense_MutationnovelR533M0.09
UCECchr932477063Missense_MutationnovelC615R0.1
UCECchr932526090Missense_MutationnovelL26P0.16
UCECchr932477112Missense_MutationNAE598D0.49
UCECchr932477075Missense_MutationNAL611I0.26
UCECchr932480219Missense_MutationNAE592K0.38
UCECchr932487945Missense_MutationnovelQ404H0.18ResIII
UCECchr932459385Missense_Mutationrs755657492V823I0.25
UCECchr932467927Missense_MutationnovelT674P0.05
UCECchr932476999Missense_MutationnovelT636I0.05
UCECchr932481387Nonsense_MutationnovelE531*0.28
UCECchr932488011Silentrs151092988P382P0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LAMLDEL0.00520.24147
TGCTDEL0.327.3329e-05
THCADEL0.02610.24038
THYMDEL0.02440.022012

Survival Analysis
CancerP-value Q-value
THYM0.021

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.0038

Kaplan-Meier Survival Analysis

MESO0.0082

Kaplan-Meier Survival Analysis

ACC0.037

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

PAAD0.0028

Kaplan-Meier Survival Analysis

READ0.04

Kaplan-Meier Survival Analysis

UCEC0.0035

Kaplan-Meier Survival Analysis

LGG0.00025

Kaplan-Meier Survival Analysis

THCA0.013

Kaplan-Meier Survival Analysis

LUAD0.038

Kaplan-Meier Survival Analysis

UVM0.045

Kaplan-Meier Survival Analysis

OV0.011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000107201 (Gene tree)
Gene ID
23586
Gene Symbol
DDX58
Alias
RIG-I|FLJ13599|DKFZp434J1111|RIG-1|RIG1
Full Name
DExD/H-box helicase 58
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
71,023 bases
Position
chr9:32,455,302-32,526,324
Accession
19102
RBP type
canonical RBP
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000369197ResIIIPF04851.156e-1711
ENSP00000369213ResIIIPF04851.151.1e-1611
ENSP00000369197RIG-I_C-RDPF11648.86e-3611
ENSP00000369213RIG-I_C-RDPF11648.89.8e-3611
ENSP00000369197DEADPF00270.298.6e-1811
ENSP00000369213DEADPF00270.291.8e-1711

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
25172485Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs.J Immunol2014 Oct 1Yang Sdoi: 10.4049/jimmunol.1401136
19478455Crystallization and preliminary crystallographic studies of human RIG-I in complex with double-stranded RNA.Acta Crystallogr Sect F Struct Biol Cryst Commun2009 Jun 1Moon Hdoi: 10.1107/S1744309109018405
19380577Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors.J Biol Chem2009 Jun 26Takahasi Kdoi: 10.1074/jbc.M109.007179
21947008Structural basis of RNA recognition and activation by innate immune receptor RIG-I.Nature2011 Sep 25Jiang Fdoi: 10.1038/nature10537.
20961956Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate.Nucleic Acids Res2011 MarLu Cdoi: 10.1093/nar/gkq974
26354181IKK negatively regulates RIG-I via direct phosphorylation.J Med Virol2016 AprZhang Xdoi: 10.1002/jmv.24376
16877044siRNA and isRNA: two edges of one sword.Mol Ther2006 OctSchlee M-
20127681DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.Eur J Immunol2010 AprOshiumi Hdoi: 10.1002/eji.200940203.
19587032Role for the paramyxovirus genomic promoter in limiting host cell antiviral responses and cell killing.J Virol2009 SepManuse MJdoi: 10.1128/JVI.01055-09
19531363Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5.Arch Biochem Biophys2009 Aug 1Li Xdoi: 10.1016/j.abb.2009.06.008
18550659Cellular La protein shields nonsegmented negative-strand RNA viral leader RNA from RIG-I and enhances virus growth by diverse mechanisms.J Virol2008 AugBitko Vdoi: 10.1128/JVI.02762-07
18268020Essential role of the N-terminal domain in the regulation of RIG-I ATPase activity.J Biol Chem2008 Apr 4Gee Pdoi: 10.1074/jbc.M706777200
17190814Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.Proc Natl Acad Sci U S A2007 Jan 9Saito T-
22301138Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5.J Virol2012 AprXing Jdoi: 10.1128/JVI.06713-11
21632559RNA helicase retinoic acid-inducible gene I as a sensor of Hantaan virus replication.J Gen Virol2011 SepLee MHdoi: 10.1099/vir.0.032367-0
27574504Dependence of RIG-I Nucleic Acid-Binding and ATP Hydrolysis on Activation of Type I Interferon Response.Immune Netw2016 AugBaek YMdoi: 10.4110/in.2016.16.4.249
24067967Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein.J Virol2013 DecKew Cdoi: 10.1128/JVI.02564-13
28180316Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.Nucleic Acids Res2017 Feb 17Fitzgerald MEdoi: 10.1093/nar/gkw816.
27651356RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling.MBio2016 Sep 20Durbin AFdoi: 10.1128/mBio.00833-16.
27625396-----
26215161Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5.BMC Biol2015 Jul 28Louber Jdoi: 10.1186/s12915-015-0166-9.
26187414A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.Immunity2015 Jul 21Schuberth-Wagner Cdoi: 10.1016/j.immuni.2015.06.015
26200004A Sense of Self: RIG-I's Tolerance to Host RNA.Immunity2015 Jul 21Schoggins JWdoi: 10.1016/j.immuni.2015.06.022.
29453856Defective RNA sensing by RIG-I in severe influenza virus infection.Clin Exp Immunol2018 JunJorgensen SEdoi: 10.1111/cei.13120
30047865Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants.Elife2018 Jul 26Lassig Cdoi: 10.7554/eLife.38958.
30804210The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance interferon-β response.J Biol Chem2019 Apr 19Kim SSdoi: 10.1074/jbc.RA118.005868
21288362Influenza C virus NS1 protein counteracts RIG-I-mediated IFN signalling.Virol J2011 Feb 2Pachler Kdoi: 10.1186/1743-422X-8-48.
19374188[Structural and functional views of the intracellular viral RNA sensor RIG-I].Uirusu2008 DecGo S-
19224987Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities.J Virol2009 MayUzri Ddoi: 10.1128/JVI.02449-08
23317505tRNA binding, structure, and localization of the human interferon-induced protein IFIT5.Mol Cell2013 Feb 21Katibah GEdoi: 10.1016/j.molcel.2012.12.015
21501829The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response.Cell Host Microbe2011 Apr 21Kok KHdoi: 10.1016/j.chom.2011.03.007.
20637642The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain.Structure2010 Aug 11Lu Cdoi: 10.1016/j.str.2010.05.007
25557055The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus.Immunity2015 Jan 20Sato Sdoi: 10.1016/j.immuni.2014.12.016
25259935RIG-I self-oligomerization is either dispensable or very transient for signal transduction.PLoS One2014 Sep 26Louber Jdoi: 10.1371/journal.pone.0108770
24931123Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.Immunity2014 Jun 19Zhu Jdoi: 10.1016/j.immuni.2014.05.007
24706898Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.Proc Natl Acad Sci U S A2014 Apr 15Kuniyoshi Kdoi: 10.1073/pnas.1401674111
24522921Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.J Virol2014 MaySiu KLdoi: 10.1128/JVI.03649-13
24220721Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus.Immunogenetics2014 JanLemos de Matos Adoi: 10.1007/s00251-013-0740-7
23950712A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.PLoS Pathog2013Oshiumi Hdoi: 10.1371/journal.ppat.1003533
27122586Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.J Virol2016 Jun 24Jiang Jdoi: 10.1128/JVI.00549-16
26525917MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.Brain2016 JanMacNair Ldoi: 10.1093/brain/awv308
26365801Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I.Structure2015 Nov 3Jureka ASdoi: 10.1016/j.str.2015.08.007
29109527The RNA binding protein La/SS-B promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection.Sci Rep2017 Nov 6Mahony Rdoi: 10.1038/s41598-017-15197-9.
29769346Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA.J Virol2018 Jul 17Fang Pdoi: 10.1128/JVI.00712-18
30158112Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response.EMBO J2018 Dec 3Wu Ydoi: 10.15252/embj.201899017
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Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000379883DDX58-2024353-ENSP00000369213925 (aa)-O95786
ENST00000379868DDX58-2014089-ENSP00000369197722 (aa)-A2A376
Gene Model
Click here to download ENSG00000107201's gene model file
Pathways
Pathway IDPathway NameSource
hsa04064NF-kappa B signaling pathwayKEGG
hsa04622RIG-I-like receptor signaling pathwayKEGG
hsa04623Cytosolic DNA-sensing pathwayKEGG
hsa05160Hepatitis CKEGG
hsa05161Hepatitis BKEGG
hsa05162MeaslesKEGG
hsa05164Influenza AKEGG
hsa05168Herpes simplex virus 1 infectionKEGG
hsa05169Epstein-Barr virus infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000107201Psoriasis6E-626626624
ENSG00000107201Psoriasis4E-725903422
ENSG00000107201Psoriasis4E-1225574825
ENSG00000107201Psoriasis6E-925574825
ENSG00000107201Menarche2E-626312577
ENSG00000107201Bone Density2E-626312577
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000107201rs11795343932523739TPsoriasis vulgaris26626624NR1.101EFO_1001494
ENSG00000107201rs11795343932523739TPsoriasis25574825[1.155-1.226]1.19EFO_0000676
ENSG00000107201rs11795343932523739?Inflammatory skin disease25574825EFO_0000676
ENSG00000107201rs10738889932458055?Bone mineral density (spine) and age at menarche26312577EFO_0004703|EFO_0007701
ENSG00000107201rs11795343932523739TPsoriasis231435941.11EFO_0000676
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000107201's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000107201DDX589634.667ENSG00000115267IFIH19731.115
ENSG00000107201DDX589432.184ENSG00000108771DHX589537.755
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000107201DDX589533.286ENSAPOG00000017013dhx589833.286Acanthochromis_polyacanthus
ENSG00000107201DDX589734.097ENSAPOG00000024529ifih19831.010Acanthochromis_polyacanthus
ENSG00000107201DDX5810081.155ENSAMEG00000003766DDX5810079.699Ailuropoda_melanoleuca
ENSG00000107201DDX589534.626ENSAMEG00000005698IFIH16935.027Ailuropoda_melanoleuca
ENSG00000107201DDX589431.556ENSAMEG00000005941DHX589731.556Ailuropoda_melanoleuca
ENSG00000107201DDX589434.410ENSACIG00000021179ifih16934.415Amphilophus_citrinellus
ENSG00000107201DDX585231.100ENSACIG00000010684dhx588631.100Amphilophus_citrinellus
ENSG00000107201DDX589332.899ENSACIG00000010643dhx589732.899Amphilophus_citrinellus
ENSG00000107201DDX589734.235ENSAOCG00000014773ifih19831.199Amphiprion_ocellaris
ENSG00000107201DDX589333.622ENSAOCG00000016713dhx589733.622Amphiprion_ocellaris
ENSG00000107201DDX589333.478ENSAPEG00000004817dhx589733.478Amphiprion_percula
ENSG00000107201DDX589734.235ENSAPEG00000018872ifih19831.199Amphiprion_percula
ENSG00000107201DDX589433.238ENSATEG00000001847dhx589733.238Anabas_testudineus
ENSG00000107201DDX589432.959ENSATEG00000018364ifih17032.959Anabas_testudineus
ENSG00000107201DDX589956.006ENSAPLG00000015091DDX589954.524Anas_platyrhynchos
ENSG00000107201DDX589434.262ENSAPLG00000010913IFIH16834.262Anas_platyrhynchos
ENSG00000107201DDX589949.309ENSACAG00000001354DDX5810046.939Anolis_carolinensis
ENSG00000107201DDX589334.789ENSACAG00000014017IFIH16834.789Anolis_carolinensis
ENSG00000107201DDX589432.046ENSACAG00000012501DHX589832.046Anolis_carolinensis
ENSG00000107201DDX589735.302ENSANAG00000028163IFIH19831.884Aotus_nancymaae
ENSG00000107201DDX589294.681ENSANAG00000031893DDX589994.681Aotus_nancymaae
ENSG00000107201DDX589432.040ENSANAG00000029056DHX589932.626Aotus_nancymaae
ENSG00000107201DDX589433.240ENSACLG00000012934ifih16933.240Astatotilapia_calliptera
ENSG00000107201DDX589632.107ENSACLG00000002582dhx589832.107Astatotilapia_calliptera
ENSG00000107201DDX589333.671ENSACLG00000002574dhx589733.671Astatotilapia_calliptera
ENSG00000107201DDX589551.585ENSAMXG00000015795-9946.186Astyanax_mexicanus
ENSG00000107201DDX589431.838ENSAMXG00000030658dhx589631.838Astyanax_mexicanus
ENSG00000107201DDX589435.211ENSAMXG00000010023ifih18531.284Astyanax_mexicanus
ENSG00000107201DDX589633.647ENSBTAG00000008142IFIH19630.267Bos_taurus
ENSG00000107201DDX589980.854ENSBTAG00000003366DDX589180.323Bos_taurus
ENSG00000107201DDX589431.746ENSBTAG00000046580DHX589831.746Bos_taurus
ENSG00000107201DDX589735.171ENSCJAG00000005956IFIH19831.691Callithrix_jacchus
ENSG00000107201DDX589431.753ENSCJAG00000014852DHX589731.753Callithrix_jacchus
ENSG00000107201DDX5810094.875ENSCJAG00000007741DDX5810094.270Callithrix_jacchus
ENSG00000107201DDX589432.612ENSCAFG00000015720DHX589732.612Canis_familiaris
ENSG00000107201DDX589982.621ENSCAFG00000001807DDX589981.701Canis_familiaris
ENSG00000107201DDX589634.483ENSCAFG00000010438IFIH17034.748Canis_familiaris
ENSG00000107201DDX589432.518ENSCAFG00020013642DHX589933.473Canis_lupus_dingo
ENSG00000107201DDX589634.483ENSCAFG00020004329IFIH19731.814Canis_lupus_dingo
ENSG00000107201DDX5810081.981ENSCAFG00020014567DDX589881.096Canis_lupus_dingo
ENSG00000107201DDX589980.165ENSCHIG00000025883DDX589879.570Capra_hircus
ENSG00000107201DDX589634.091ENSCHIG00000019848IFIH19630.875Capra_hircus
ENSG00000107201DDX589431.178ENSCHIG00000017011DHX589831.178Capra_hircus
ENSG00000107201DDX589234.583ENSTSYG00000005900IFIH19731.176Carlito_syrichta
ENSG00000107201DDX5810085.734ENSTSYG00000004200DDX5810084.881Carlito_syrichta
ENSG00000107201DDX585030.423ENSTSYG00000032842-9530.423Carlito_syrichta
ENSG00000107201DDX588231.639ENSCAPG00000016521DHX589931.475Cavia_aperea
ENSG00000107201DDX5810060.246ENSCAPG00000007816DDX5810059.133Cavia_aperea
ENSG00000107201DDX589533.649ENSCAPG00000009502IFIH19732.999Cavia_aperea
ENSG00000107201DDX589634.048ENSCPOG00000007154IFIH19731.465Cavia_porcellus
ENSG00000107201DDX5810078.255ENSCPOG00000001598DDX5810076.998Cavia_porcellus
ENSG00000107201DDX589431.313ENSCPOG00000023721DHX589731.169Cavia_porcellus
ENSG00000107201DDX589431.897ENSCCAG00000022542DHX589731.897Cebus_capucinus
ENSG00000107201DDX589735.039ENSCCAG00000027248IFIH19831.594Cebus_capucinus
ENSG00000107201DDX5810093.213ENSCCAG00000036752DDX5810093.189Cebus_capucinus
ENSG00000107201DDX5810096.973ENSCATG00000040246DDX5810096.973Cercocebus_atys
ENSG00000107201DDX589634.672ENSCATG00000032062IFIH19731.146Cercocebus_atys
ENSG00000107201DDX589432.328ENSCATG00000043180DHX589635.514Cercocebus_atys
ENSG00000107201DDX589831.342ENSCLAG00000008509IFIH19731.342Chinchilla_lanigera
ENSG00000107201DDX5810077.147ENSCLAG00000002351DDX5810076.142Chinchilla_lanigera
ENSG00000107201DDX589431.412ENSCLAG00000013960DHX589731.556Chinchilla_lanigera
ENSG00000107201DDX589634.672ENSCSAG00000015614IFIH19731.109Chlorocebus_sabaeus
ENSG00000107201DDX589432.184ENSCSAG00000003082DHX589732.184Chlorocebus_sabaeus
ENSG00000107201DDX5810096.541ENSCSAG00000009834DDX5810096.541Chlorocebus_sabaeus
ENSG00000107201DDX589974.483ENSCHOG00000009019DDX589374.365Choloepus_hoffmanni
ENSG00000107201DDX589032.684ENSCPBG00000006804DHX589532.684Chrysemys_picta_bellii
ENSG00000107201DDX589958.832ENSCPBG00000008101DDX589956.821Chrysemys_picta_bellii
ENSG00000107201DDX589434.521ENSCPBG00000026441IFIH16934.530Chrysemys_picta_bellii
ENSG00000107201DDX589131.471ENSCING00000009744-9731.471Ciona_intestinalis
ENSG00000107201DDX589431.897ENSCANG00000031041DHX589731.897Colobus_angolensis_palliatus
ENSG00000107201DDX589235.466ENSCANG00000031775IFIH19731.176Colobus_angolensis_palliatus
ENSG00000107201DDX5810096.973ENSCANG00000031971DDX5810096.973Colobus_angolensis_palliatus
ENSG00000107201DDX589979.612ENSCGRG00001024123Ddx589979.027Cricetulus_griseus_chok1gshd
ENSG00000107201DDX589434.600ENSCGRG00001024740Ifih19631.166Cricetulus_griseus_chok1gshd
ENSG00000107201DDX589432.756ENSCGRG00001010336Dhx589732.756Cricetulus_griseus_chok1gshd
ENSG00000107201DDX589434.600ENSCGRG00000010637Ifih19631.166Cricetulus_griseus_crigri
ENSG00000107201DDX589970.645ENSCGRG00000003581Ddx589970.645Cricetulus_griseus_crigri
ENSG00000107201DDX589432.756ENSCGRG00000008364Dhx589732.756Cricetulus_griseus_crigri
ENSG00000107201DDX589331.205ENSCSEG00000021382dhx589631.205Cynoglossus_semilaevis
ENSG00000107201DDX589432.821ENSCSEG00000010056ifih19030.796Cynoglossus_semilaevis
ENSG00000107201DDX589434.262ENSCVAG00000002089ifih19531.217Cyprinodon_variegatus
ENSG00000107201DDX589533.906ENSCVAG00000009503dhx589833.906Cyprinodon_variegatus
ENSG00000107201DDX589930.276ENSDARG00000018553ifih19735.203Danio_rerio
ENSG00000107201DDX589433.333ENSDARG00000089463dhx589934.186Danio_rerio
ENSG00000107201DDX587330.115ENSDNOG00000043127DHX589730.115Dasypus_novemcinctus
ENSG00000107201DDX5810080.220ENSDNOG00000003968DDX5810079.077Dasypus_novemcinctus
ENSG00000107201DDX589634.441ENSDNOG00000012100IFIH19331.841Dasypus_novemcinctus
ENSG00000107201DDX589634.501ENSDORG00000001907Ifih19731.884Dipodomys_ordii
ENSG00000107201DDX589430.836ENSDORG00000006815Dhx589830.836Dipodomys_ordii
ENSG00000107201DDX589978.363ENSDORG00000027625Ddx589977.670Dipodomys_ordii
ENSG00000107201DDX589436.466ENSEBUG00000014150DDX589736.908Eptatretus_burgeri
ENSG00000107201DDX588034.343ENSEBUG00000012092IFIH18934.343Eptatretus_burgeri
ENSG00000107201DDX589432.281ENSEBUG00000007527dhx589931.019Eptatretus_burgeri
ENSG00000107201DDX589331.250ENSEASG00005009112DHX589731.178Equus_asinus_asinus
ENSG00000107201DDX5810082.393ENSEASG00005004589DDX589181.633Equus_asinus_asinus
ENSG00000107201DDX589031.118ENSEASG00005022976IFIH19931.118Equus_asinus_asinus
ENSG00000107201DDX589982.507ENSECAG00000021989DDX589981.971Equus_caballus
ENSG00000107201DDX589434.563ENSECAG00000007881IFIH19531.682Equus_caballus
ENSG00000107201DDX589331.433ENSECAG00000011439DHX589731.304Equus_caballus
ENSG00000107201DDX589334.444ENSEEUG00000005153IFIH16834.722Erinaceus_europaeus
ENSG00000107201DDX588676.596ENSEEUG00000015254DDX588676.596Erinaceus_europaeus
ENSG00000107201DDX588442.540ENSELUG00000005444-9542.540Esox_lucius
ENSG00000107201DDX589433.761ENSELUG00000018439dhx589733.761Esox_lucius
ENSG00000107201DDX589432.418ENSELUG00000019690ifih17432.548Esox_lucius
ENSG00000107201DDX5810084.319ENSFCAG00000001294DDX5810082.492Felis_catus
ENSG00000107201DDX589634.441ENSFCAG00000023951IFIH17034.441Felis_catus
ENSG00000107201DDX589433.141ENSFCAG00000002145DHX589633.141Felis_catus
ENSG00000107201DDX589955.989ENSFALG00000001146DDX589954.732Ficedula_albicollis
ENSG00000107201DDX588732.198ENSFALG00000000653DHX589732.198Ficedula_albicollis
ENSG00000107201DDX589434.807ENSFALG00000000721IFIH16834.807Ficedula_albicollis
ENSG00000107201DDX589431.077ENSFDAG00000018042DHX589430.979Fukomys_damarensis
ENSG00000107201DDX587277.735ENSFDAG00000011958-10077.735Fukomys_damarensis
ENSG00000107201DDX589333.379ENSFDAG00000013122IFIH19330.660Fukomys_damarensis
ENSG00000107201DDX589435.294ENSFHEG00000022714ifih19531.983Fundulus_heteroclitus
ENSG00000107201DDX589534.659ENSFHEG00000012195dhx589834.659Fundulus_heteroclitus
ENSG00000107201DDX589331.772ENSGMOG00000015145dhx589731.772Gadus_morhua
ENSG00000107201DDX589333.048ENSGMOG00000014790ifih16833.048Gadus_morhua
ENSG00000107201DDX589633.691ENSGALG00000041192IFIH16533.691Gallus_gallus
ENSG00000107201DDX589332.023ENSGALG00000023821DHX589732.023Gallus_gallus
ENSG00000107201DDX589435.162ENSGAFG00000007593ifih19531.707Gambusia_affinis
ENSG00000107201DDX589333.864ENSGAFG00000000986dhx589833.864Gambusia_affinis
ENSG00000107201DDX589333.624ENSGACG00000008740dhx589633.624Gasterosteus_aculeatus
ENSG00000107201DDX589433.801ENSGACG00000005518ifih16833.801Gasterosteus_aculeatus
ENSG00000107201DDX589734.718ENSGAGG00000007126IFIH17134.834Gopherus_agassizii
ENSG00000107201DDX589958.275ENSGAGG00000018278DDX589956.284Gopherus_agassizii
ENSG00000107201DDX589033.234ENSGAGG00000023270DHX589533.234Gopherus_agassizii
ENSG00000107201DDX589634.800ENSGGOG00000015893IFIH19731.115Gorilla_gorilla
ENSG00000107201DDX5810099.861ENSGGOG00000016335DDX5810099.784Gorilla_gorilla
ENSG00000107201DDX589431.897ENSGGOG00000005458DHX589731.897Gorilla_gorilla
ENSG00000107201DDX589333.526ENSHBUG00000001953dhx589733.526Haplochromis_burtoni
ENSG00000107201DDX589632.532ENSHBUG00000001963dhx589832.532Haplochromis_burtoni
ENSG00000107201DDX589932.680ENSHBUG00000004855ifih17532.680Haplochromis_burtoni
ENSG00000107201DDX589232.719ENSHGLG00000011529DHX588232.719Heterocephalus_glaber_female
ENSG00000107201DDX5810079.778ENSHGLG00000016504DDX5810078.294Heterocephalus_glaber_female
ENSG00000107201DDX589631.841ENSHGLG00000008772IFIH19330.739Heterocephalus_glaber_female
ENSG00000107201DDX589631.714ENSHGLG00100002141IFIH19330.640Heterocephalus_glaber_male
ENSG00000107201DDX5810079.778ENSHGLG00100000205DDX5810078.294Heterocephalus_glaber_male
ENSG00000107201DDX589431.124ENSHGLG00100009705DHX589731.124Heterocephalus_glaber_male
ENSG00000107201DDX589631.586ENSHCOG00000004788dhx589931.728Hippocampus_comes
ENSG00000107201DDX589933.690ENSHCOG00000016423ifih19530.901Hippocampus_comes
ENSG00000107201DDX589432.272ENSIPUG00000019893dhx589732.272Ictalurus_punctatus
ENSG00000107201DDX589435.112ENSIPUG00000013367ifih16835.112Ictalurus_punctatus
ENSG00000107201DDX589947.548ENSIPUG00000003114ddx589942.887Ictalurus_punctatus
ENSG00000107201DDX589980.389ENSSTOG00000006994DDX589979.523Ictidomys_tridecemlineatus
ENSG00000107201DDX589633.512ENSSTOG00000004953IFIH19730.315Ictidomys_tridecemlineatus
ENSG00000107201DDX589431.169ENSSTOG00000006524DHX589731.169Ictidomys_tridecemlineatus
ENSG00000107201DDX587978.962ENSJJAG00000004582Ddx589978.962Jaculus_jaculus
ENSG00000107201DDX589831.020ENSJJAG00000018669Ifih19731.020Jaculus_jaculus
ENSG00000107201DDX589330.836ENSJJAG00000000855Dhx589730.647Jaculus_jaculus
ENSG00000107201DDX589532.956ENSKMAG00000020096dhx589932.956Kryptolebias_marmoratus
ENSG00000107201DDX589833.244ENSKMAG00000014309ifih19830.325Kryptolebias_marmoratus
ENSG00000107201DDX589432.999ENSLBEG00000004224dhx589732.999Labrus_bergylta
ENSG00000107201DDX589934.166ENSLBEG00000005389ifih19531.563Labrus_bergylta
ENSG00000107201DDX589853.073ENSLACG00000000411DDX589950.915Latimeria_chalumnae
ENSG00000107201DDX589430.780ENSLACG00000011208DHX589830.780Latimeria_chalumnae
ENSG00000107201DDX589436.740ENSLACG00000011448IFIH19536.740Latimeria_chalumnae
ENSG00000107201DDX589843.436ENSLOCG00000006504-9743.436Lepisosteus_oculatus
ENSG00000107201DDX589534.758ENSLOCG00000012582dhx589734.758Lepisosteus_oculatus
ENSG00000107201DDX589951.791ENSLOCG00000013422DDX589848.822Lepisosteus_oculatus
ENSG00000107201DDX589435.154ENSLOCG00000008460ifih19731.004Lepisosteus_oculatus
ENSG00000107201DDX589236.155ENSLAFG00000009997IFIH16736.155Loxodonta_africana
ENSG00000107201DDX5810080.959ENSLAFG00000005416DDX5810079.336Loxodonta_africana
ENSG00000107201DDX589430.504ENSLAFG00000027301DHX589730.504Loxodonta_africana
ENSG00000107201DDX589634.672ENSMFAG00000003848IFIH19731.109Macaca_fascicularis
ENSG00000107201DDX589432.328ENSMFAG00000034530DHX589635.514Macaca_fascicularis
ENSG00000107201DDX5810095.152ENSMFAG00000045674DDX5810095.152Macaca_fascicularis
ENSG00000107201DDX589432.328ENSMMUG00000014755DHX589635.514Macaca_mulatta
ENSG00000107201DDX5810095.784ENSMMUG00000012442DDX5810095.784Macaca_mulatta
ENSG00000107201DDX589634.672ENSMMUG00000003202IFIH19731.109Macaca_mulatta
ENSG00000107201DDX5810095.892ENSMNEG00000041909DDX5810095.892Macaca_nemestrina
ENSG00000107201DDX589432.328ENSMNEG00000043994DHX589635.514Macaca_nemestrina
ENSG00000107201DDX589634.672ENSMNEG00000032734IFIH19731.109Macaca_nemestrina
ENSG00000107201DDX589432.328ENSMLEG00000042616DHX589635.514Mandrillus_leucophaeus
ENSG00000107201DDX5810096.108ENSMLEG00000029982DDX5810096.108Mandrillus_leucophaeus
ENSG00000107201DDX589634.806ENSMLEG00000000107IFIH17034.806Mandrillus_leucophaeus
ENSG00000107201DDX589433.939ENSMAMG00000003380ifih19531.441Mastacembelus_armatus
ENSG00000107201DDX589332.602ENSMAMG00000022316dhx589632.602Mastacembelus_armatus
ENSG00000107201DDX589333.815ENSMZEG00005022742dhx589733.815Maylandia_zebra
ENSG00000107201DDX589632.673ENSMZEG00005022739dhx589832.673Maylandia_zebra
ENSG00000107201DDX589433.240ENSMZEG00005007158ifih17033.240Maylandia_zebra
ENSG00000107201DDX589633.917ENSMGAG00000010882IFIH17233.917Meleagris_gallopavo
ENSG00000107201DDX588231.220ENSMGAG00000006752DHX589731.220Meleagris_gallopavo
ENSG00000107201DDX589432.374ENSMAUG00000019934Dhx589732.225Mesocricetus_auratus
ENSG00000107201DDX589979.057ENSMAUG00000021814Ddx589974.190Mesocricetus_auratus
ENSG00000107201DDX589433.829ENSMICG00000005405IFIH19530.709Microcebus_murinus
ENSG00000107201DDX5810088.227ENSMICG00000006555DDX5810088.227Microcebus_murinus
ENSG00000107201DDX589730.833ENSMOCG00000011565Ifih19630.833Microtus_ochrogaster
ENSG00000107201DDX589432.277ENSMOCG00000019066Dhx589732.421Microtus_ochrogaster
ENSG00000107201DDX588878.807ENSMOCG00000006173Ddx589978.807Microtus_ochrogaster
ENSG00000107201DDX589434.631ENSMMOG00000003652ifih19530.922Mola_mola
ENSG00000107201DDX589333.186ENSMMOG00000020631dhx589633.186Mola_mola
ENSG00000107201DDX589930.179ENSMODG00000005628IFIH19830.179Monodelphis_domestica
ENSG00000107201DDX589431.358ENSMODG00000014782DHX589631.358Monodelphis_domestica
ENSG00000107201DDX589333.721ENSMALG00000006556dhx589733.721Monopterus_albus
ENSG00000107201DDX589833.950ENSMALG00000015489ifih19830.589Monopterus_albus
ENSG00000107201DDX589631.661MGP_CAROLIEiJ_G0023594Ifih19531.661Mus_caroli
ENSG00000107201DDX589433.237MGP_CAROLIEiJ_G0017181Dhx589733.237Mus_caroli
ENSG00000107201DDX589977.917MGP_CAROLIEiJ_G0025893Ddx589976.649Mus_caroli
ENSG00000107201DDX589978.194ENSMUSG00000040296Ddx589977.081Mus_musculus
ENSG00000107201DDX589234.535ENSMUSG00000026896Ifih19332.051Mus_musculus
ENSG00000107201DDX589433.622ENSMUSG00000017830Dhx589733.622Mus_musculus
ENSG00000107201DDX589433.285MGP_PahariEiJ_G0018311Dhx589733.285Mus_pahari
ENSG00000107201DDX589970.000MGP_PahariEiJ_G0024016Ddx589969.405Mus_pahari
ENSG00000107201DDX589830.502MGP_PahariEiJ_G0025045Ifih19730.502Mus_pahari
ENSG00000107201DDX589234.258MGP_SPRETEiJ_G0024516Ifih19331.624Mus_spretus
ENSG00000107201DDX589433.622MGP_SPRETEiJ_G0018024Dhx589733.622Mus_spretus
ENSG00000107201DDX589977.778MGP_SPRETEiJ_G0026842Ddx589976.541Mus_spretus
ENSG00000107201DDX589380.560ENSMPUG00000004319DDX589179.882Mustela_putorius_furo
ENSG00000107201DDX589432.853ENSMPUG00000010568DHX589732.853Mustela_putorius_furo
ENSG00000107201DDX589634.840ENSMPUG00000000564IFIH17035.372Mustela_putorius_furo
ENSG00000107201DDX589234.626ENSMLUG00000009505IFIH19630.754Myotis_lucifugus
ENSG00000107201DDX589981.981ENSMLUG00000003041DDX5810081.633Myotis_lucifugus
ENSG00000107201DDX589431.457ENSMLUG00000012001DHX589731.457Myotis_lucifugus
ENSG00000107201DDX5810078.393ENSNGAG00000003642Ddx5810077.754Nannospalax_galili
ENSG00000107201DDX589830.967ENSNGAG00000012752Ifih19730.967Nannospalax_galili
ENSG00000107201DDX589331.936ENSNGAG00000017107Dhx589632.277Nannospalax_galili
ENSG00000107201DDX589632.390ENSNBRG00000018263dhx589832.390Neolamprologus_brichardi
ENSG00000107201DDX589333.817ENSNBRG00000018515dhx589633.817Neolamprologus_brichardi
ENSG00000107201DDX589433.801ENSNBRG00000014585ifih19530.526Neolamprologus_brichardi
ENSG00000107201DDX589831.655ENSNLEG00000026782IFIH19731.655Nomascus_leucogenys
ENSG00000107201DDX588386.644ENSNLEG00000034971-9586.644Nomascus_leucogenys
ENSG00000107201DDX589230.362ENSMEUG00000003310IFIH16830.362Notamacropus_eugenii
ENSG00000107201DDX589433.671ENSMEUG00000005569DHX589933.671Notamacropus_eugenii
ENSG00000107201DDX588665.979ENSMEUG00000011210-8165.979Notamacropus_eugenii
ENSG00000107201DDX589432.319ENSOPRG00000000753DHX589732.319Ochotona_princeps
ENSG00000107201DDX588869.704ENSOPRG00000016806-7969.697Ochotona_princeps
ENSG00000107201DDX587632.776ENSOPRG00000015760IFIH15732.776Ochotona_princeps
ENSG00000107201DDX589633.869ENSODEG00000013586IFIH19631.276Octodon_degus
ENSG00000107201DDX5810077.424ENSODEG00000015750DDX5810076.458Octodon_degus
ENSG00000107201DDX589431.556ENSODEG00000017902DHX589731.556Octodon_degus
ENSG00000107201DDX589433.566ENSONIG00000008901ifih16933.566Oreochromis_niloticus
ENSG00000107201DDX589963.764ENSOANG00000012131DDX589961.814Ornithorhynchus_anatinus
ENSG00000107201DDX588636.157ENSOANG00000006194IFIH18132.426Ornithorhynchus_anatinus
ENSG00000107201DDX589432.319ENSOCUG00000013278DHX589732.319Oryctolagus_cuniculus
ENSG00000107201DDX5810079.086ENSOCUG00000004710DDX5810078.196Oryctolagus_cuniculus
ENSG00000107201DDX589235.794ENSOCUG00000002863IFIH19431.864Oryctolagus_cuniculus
ENSG00000107201DDX589532.528ENSORLG00000003825dhx589732.518Oryzias_latipes
ENSG00000107201DDX589833.869ENSORLG00000016902ifih19831.552Oryzias_latipes
ENSG00000107201DDX589532.244ENSORLG00020008521dhx589732.230Oryzias_latipes_hni
ENSG00000107201DDX589833.869ENSORLG00020022369ifih19831.452Oryzias_latipes_hni
ENSG00000107201DDX589532.244ENSORLG00015022015dhx589732.230Oryzias_latipes_hsok
ENSG00000107201DDX589833.869ENSORLG00015017957ifih19831.452Oryzias_latipes_hsok
ENSG00000107201DDX589333.906ENSOMEG00000023054dhx589933.906Oryzias_melastigma
ENSG00000107201DDX589931.420ENSOMEG00000002513ifih19831.521Oryzias_melastigma
ENSG00000107201DDX587433.028ENSOMEG00000023026dhx589533.028Oryzias_melastigma
ENSG00000107201DDX5810085.180ENSOGAG00000010536DDX5810084.449Otolemur_garnettii
ENSG00000107201DDX589334.716ENSOGAG00000012611IFIH16834.716Otolemur_garnettii
ENSG00000107201DDX589330.636ENSOGAG00000025321DHX589630.636Otolemur_garnettii
ENSG00000107201DDX589979.890ENSOARG00000014731DDX589879.355Ovis_aries
ENSG00000107201DDX589634.137ENSOARG00000006142IFIH19630.754Ovis_aries
ENSG00000107201DDX589431.746ENSOARG00000018383DHX589831.746Ovis_aries
ENSG00000107201DDX589634.667ENSPPAG00000038665IFIH19731.115Pan_paniscus
ENSG00000107201DDX5810099.892ENSPPAG00000041750DDX5810099.892Pan_paniscus
ENSG00000107201DDX589432.184ENSPPAG00000031118DHX589732.184Pan_paniscus
ENSG00000107201DDX5810084.594ENSPPRG00000010161DDX5810082.707Panthera_pardus
ENSG00000107201DDX589432.853ENSPPRG00000004933DHX589632.853Panthera_pardus
ENSG00000107201DDX589634.441ENSPPRG00000024685IFIH17034.441Panthera_pardus
ENSG00000107201DDX589432.997ENSPTIG00000007982DHX589632.997Panthera_tigris_altaica
ENSG00000107201DDX589634.441ENSPTIG00000019898IFIH16934.441Panthera_tigris_altaica
ENSG00000107201DDX5810084.594ENSPTIG00000015345DDX5810082.599Panthera_tigris_altaica
ENSG00000107201DDX58100100.000ENSPTRG00000020844DDX58100100.000Pan_troglodytes
ENSG00000107201DDX589432.184ENSPTRG00000009191DHX589732.184Pan_troglodytes
ENSG00000107201DDX589634.667ENSPTRG00000012582IFIH19731.115Pan_troglodytes
ENSG00000107201DDX589435.238ENSPANG00000023890IFIH19431.281Papio_anubis
ENSG00000107201DDX5810096.324ENSPANG00000025269DDX5810096.324Papio_anubis
ENSG00000107201DDX589432.328ENSPANG00000021475DHX589635.514Papio_anubis
ENSG00000107201DDX589950.345ENSPKIG00000017174DDX589947.966Paramormyrops_kingsleyae
ENSG00000107201DDX589434.429ENSPKIG00000020140dhx589734.789Paramormyrops_kingsleyae
ENSG00000107201DDX589434.225ENSPKIG00000001054ifih17134.507Paramormyrops_kingsleyae
ENSG00000107201DDX589434.759ENSPSIG00000007364IFIH19530.495Pelodiscus_sinensis
ENSG00000107201DDX589958.889ENSPSIG00000013490DDX589956.681Pelodiscus_sinensis
ENSG00000107201DDX589731.806ENSPMGG00000006236ifih19530.552Periophthalmus_magnuspinnatus
ENSG00000107201DDX589533.381ENSPMGG00000010442dhx589833.381Periophthalmus_magnuspinnatus
ENSG00000107201DDX589432.323ENSPEMG00000018681Dhx589732.323Peromyscus_maniculatus_bairdii
ENSG00000107201DDX589434.328ENSPEMG00000014586Ifih19331.045Peromyscus_maniculatus_bairdii
ENSG00000107201DDX589979.861ENSPEMG00000012372Ddx589979.676Peromyscus_maniculatus_bairdii
ENSG00000107201DDX587842.660ENSPMAG00000009697DDX589642.660Petromyzon_marinus
ENSG00000107201DDX586931.041ENSPMAG00000007346-9931.189Petromyzon_marinus
ENSG00000107201DDX589967.538ENSPCIG00000029320RIG-I9964.850Phascolarctos_cinereus
ENSG00000107201DDX589234.310ENSPCIG00000030338IFIH17434.449Phascolarctos_cinereus
ENSG00000107201DDX589432.615ENSPCIG00000020229LGP29832.615Phascolarctos_cinereus
ENSG00000107201DDX589931.670ENSPFOG00000017223ifih19731.670Poecilia_formosa
ENSG00000107201DDX589434.483ENSPFOG00000011777dhx589834.483Poecilia_formosa
ENSG00000107201DDX589931.670ENSPLAG00000000949ifih19731.670Poecilia_latipinna
ENSG00000107201DDX589434.339ENSPLAG00000021657dhx589834.339Poecilia_latipinna
ENSG00000107201DDX589434.438ENSPMEG00000011404dhx589834.438Poecilia_mexicana
ENSG00000107201DDX589931.606ENSPMEG00000016070ifih19731.606Poecilia_mexicana
ENSG00000107201DDX589635.422ENSPREG00000007796ifih19731.122Poecilia_reticulata
ENSG00000107201DDX589434.582ENSPREG00000010240dhx589834.582Poecilia_reticulata
ENSG00000107201DDX5810098.476ENSPPYG00000019149DDX5810098.743Pongo_abelii
ENSG00000107201DDX589634.441ENSPPYG00000012887IFIH17034.441Pongo_abelii
ENSG00000107201DDX586736.278ENSPCAG00000007680IFIH18630.947Procavia_capensis
ENSG00000107201DDX587630.243ENSPCAG00000016244DHX588630.243Procavia_capensis
ENSG00000107201DDX586581.707ENSPCAG00000016086-7181.707Procavia_capensis
ENSG00000107201DDX589633.865ENSPCOG00000021673IFIH19730.574Propithecus_coquereli
ENSG00000107201DDX5810084.488ENSPCOG00000027117DDX589984.488Propithecus_coquereli
ENSG00000107201DDX5810084.319ENSPVAG00000009207DDX5810083.333Pteropus_vampyrus
ENSG00000107201DDX589431.594ENSPVAG00000003855DHX589731.594Pteropus_vampyrus
ENSG00000107201DDX589031.489ENSPVAG00000002643IFIH16731.631Pteropus_vampyrus
ENSG00000107201DDX589433.380ENSPNYG00000002971ifih19430.083Pundamilia_nyererei
ENSG00000107201DDX589333.965ENSPNYG00000010782dhx589733.965Pundamilia_nyererei
ENSG00000107201DDX588037.681ENSPNYG00000010709dhx589837.681Pundamilia_nyererei
ENSG00000107201DDX589432.997ENSPNAG00000028648dhx589732.997Pygocentrus_nattereri
ENSG00000107201DDX589934.533ENSPNAG00000023802ifih18532.143Pygocentrus_nattereri
ENSG00000107201DDX589550.794ENSPNAG00000002347-9945.435Pygocentrus_nattereri
ENSG00000107201DDX586476.351ENSRNOG00000006384Ddx589976.351Rattus_norvegicus
ENSG00000107201DDX589234.163ENSRNOG00000006227Ifih16834.163Rattus_norvegicus
ENSG00000107201DDX589433.813ENSRNOG00000018247Dhx589733.813Rattus_norvegicus
ENSG00000107201DDX589434.789ENSRBIG00000029188IFIH19830.915Rhinopithecus_bieti
ENSG00000107201DDX589432.328ENSRBIG00000028906DHX589635.514Rhinopithecus_bieti
ENSG00000107201DDX5810096.676ENSRBIG00000040257DDX5810096.676Rhinopithecus_bieti
ENSG00000107201DDX5810096.649ENSRROG00000029512DDX5810096.649Rhinopithecus_roxellana
ENSG00000107201DDX589634.672ENSRROG00000030959IFIH19730.882Rhinopithecus_roxellana
ENSG00000107201DDX588631.669ENSRROG00000035891DHX589635.514Rhinopithecus_roxellana
ENSG00000107201DDX589431.897ENSSBOG00000020589DHX589731.897Saimiri_boliviensis_boliviensis
ENSG00000107201DDX589931.014ENSSBOG00000026205IFIH19731.832Saimiri_boliviensis_boliviensis
ENSG00000107201DDX589993.620ENSSBOG00000030627DDX589993.506Saimiri_boliviensis_boliviensis
ENSG00000107201DDX589433.572ENSSHAG00000006130DHX589833.572Sarcophilus_harrisii
ENSG00000107201DDX589730.336ENSSHAG00000017981IFIH19630.435Sarcophilus_harrisii
ENSG00000107201DDX589452.632ENSSFOG00015017386ddx589947.329Scleropages_formosus
ENSG00000107201DDX589434.685ENSSFOG00015022705ifih17634.825Scleropages_formosus
ENSG00000107201DDX589434.776ENSSFOG00015023124dhx589734.776Scleropages_formosus
ENSG00000107201DDX589930.378ENSSMAG00000012345ifih19931.102Scophthalmus_maximus
ENSG00000107201DDX589632.815ENSSMAG00000007427dhx589932.815Scophthalmus_maximus
ENSG00000107201DDX589833.862ENSSDUG00000019000ifih19830.715Seriola_dumerili
ENSG00000107201DDX589432.235ENSSDUG00000022971dhx589732.235Seriola_dumerili
ENSG00000107201DDX589833.995ENSSLDG00000016351ifih19830.653Seriola_lalandi_dorsalis
ENSG00000107201DDX589432.235ENSSLDG00000017659dhx589732.235Seriola_lalandi_dorsalis
ENSG00000107201DDX589268.538ENSSARG00000008445DDX589368.538Sorex_araneus
ENSG00000107201DDX586731.481ENSSARG00000002192DHX587231.481Sorex_araneus
ENSG00000107201DDX589633.243ENSSPUG00000017377IFIH18430.174Sphenodon_punctatus
ENSG00000107201DDX589432.851ENSSPUG00000012993DHX589832.851Sphenodon_punctatus
ENSG00000107201DDX589959.218ENSSPUG00000002608DDX589956.606Sphenodon_punctatus
ENSG00000107201DDX589930.031ENSSPAG00000000528ifih19830.271Stegastes_partitus
ENSG00000107201DDX589333.527ENSSPAG00000006485dhx589733.527Stegastes_partitus
ENSG00000107201DDX589979.201ENSSSCG00000030408DDX589979.976Sus_scrofa
ENSG00000107201DDX589432.035ENSSSCG00000017416DHX589732.035Sus_scrofa
ENSG00000107201DDX589731.031ENSSSCG00000015897IFIH19631.134Sus_scrofa
ENSG00000107201DDX589434.328ENSTGUG00000006914IFIH16934.328Taeniopygia_guttata
ENSG00000107201DDX589432.950ENSTGUG00000002516DHX589932.950Taeniopygia_guttata
ENSG00000107201DDX589755.064ENSTGUG00000001516DDX5810053.115Taeniopygia_guttata
ENSG00000107201DDX589930.426ENSTRUG00000001413ifih19730.426Takifugu_rubripes
ENSG00000107201DDX589334.626ENSTRUG00000015710dhx589734.638Takifugu_rubripes
ENSG00000107201DDX589333.041ENSTNIG00000011713dhx589533.041Tetraodon_nigroviridis
ENSG00000107201DDX589433.146ENSTNIG00000016500ifih16833.146Tetraodon_nigroviridis
ENSG00000107201DDX585435.889ENSTBEG00000005427DHX585635.889Tupaia_belangeri
ENSG00000107201DDX589131.769ENSTBEG00000005625IFIH18831.769Tupaia_belangeri
ENSG00000107201DDX589431.511ENSTTRG00000006650DHX589731.655Tursiops_truncatus
ENSG00000107201DDX589231.528ENSTTRG00000013780IFIH16831.528Tursiops_truncatus
ENSG00000107201DDX589978.225ENSTTRG00000016993DDX589978.316Tursiops_truncatus
ENSG00000107201DDX589431.548ENSUAMG00000024348DHX589731.548Ursus_americanus
ENSG00000107201DDX5810082.271ENSUAMG00000020703DDX5810080.778Ursus_americanus
ENSG00000107201DDX589534.707ENSUAMG00000015811IFIH19631.893Ursus_americanus
ENSG00000107201DDX589334.959ENSUMAG00000012031IFIH19531.663Ursus_maritimus
ENSG00000107201DDX5810081.431ENSUMAG00000005813DDX5810080.021Ursus_maritimus
ENSG00000107201DDX589430.483ENSUMAG00000023000DHX589830.483Ursus_maritimus
ENSG00000107201DDX5810078.393ENSVPAG00000009880DDX589978.876Vicugna_pacos
ENSG00000107201DDX589231.944ENSVPAG00000010823IFIH17932.361Vicugna_pacos
ENSG00000107201DDX589634.574ENSVVUG00000018569IFIH19731.445Vulpes_vulpes
ENSG00000107201DDX5810081.706ENSVVUG00000021149DDX5810081.158Vulpes_vulpes
ENSG00000107201DDX589431.250ENSVVUG00000020914DHX589731.250Vulpes_vulpes
ENSG00000107201DDX589333.616ENSXETG00000013176ifih16733.616Xenopus_tropicalis
ENSG00000107201DDX589433.141ENSXETG00000002302dhx589733.143Xenopus_tropicalis
ENSG00000107201DDX589951.140ENSXETG00000009200ddx589951.140Xenopus_tropicalis
ENSG00000107201DDX589835.207ENSXCOG00000019338ifih19331.965Xiphophorus_couchianus
ENSG00000107201DDX589735.142ENSXMAG00000011536ifih19332.324Xiphophorus_maculatus
ENSG00000107201DDX589434.339ENSXMAG00000008899dhx589834.339Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0002230positive regulation of defense response to virus by host19609254.IMPProcess
GO:0002735positive regulation of myeloid dendritic cell cytokine production-ISSProcess
GO:0003690double-stranded DNA binding-IEAFunction
GO:0003725double-stranded RNA binding19576794.IDAFunction
GO:0003725double-stranded RNA binding19211564.IMPFunction
GO:0003725double-stranded RNA binding17079289.TASFunction
GO:0003727single-stranded RNA binding19211564.IMPFunction
GO:0004386helicase activity-IEAFunction
GO:0005515protein binding16127453.16177806.16281057.17079289.17190814.17460044.18636086.18724357.19017631.19164550.19193793.19419966.20007272.20127681.20434986.20818395.21102435.21791617.21813773.21903422.22152002.22301138.22328336.22623778.23552410.23843640.23870315.24360797.24478431.27824081.30193849.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005737cytoplasm21102435.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005923bicellular tight junction19122199.IDAComponent
GO:0008270zinc ion binding18243112.IDAFunction
GO:0009597detection of virus17079289.IDAProcess
GO:0009615response to virus21616437.TASProcess
GO:0010628positive regulation of gene expression24409285.IDAProcess
GO:0015629actin cytoskeleton19122199.IDAComponent
GO:0016032viral process-IEAProcess
GO:0016579protein deubiquitination-TASProcess
GO:0030334regulation of cell migration19122199.IDAProcess
GO:0031625ubiquitin protein ligase binding26471729.IPIFunction
GO:0032480negative regulation of type I interferon production-TASProcess
GO:0032587ruffle membrane19122199.IDAComponent
GO:0032725positive regulation of granulocyte macrophage colony-stimulating factor production24409285.IDAProcess
GO:0032727positive regulation of interferon-alpha production19576794.IDAProcess
GO:0032727positive regulation of interferon-alpha production19609254.IMPProcess
GO:0032728positive regulation of interferon-beta production17079289.IDAProcess
GO:0032728positive regulation of interferon-beta production19211564.19609254.19631370.IMPProcess
GO:0032755positive regulation of interleukin-6 production24409285.IDAProcess
GO:0032757positive regulation of interleukin-8 production24409285.IDAProcess
GO:0034344regulation of type III interferon production21616437.TASProcess
GO:0035549positive regulation of interferon-beta secretion21957149.IMPProcess
GO:0039528cytoplasmic pattern recognition receptor signaling pathway in response to virus21616437.TASProcess
GO:0039529RIG-I signaling pathway19211564.IMPProcess
GO:0042802identical protein binding21102435.IPIFunction
GO:0043330response to exogenous dsRNA-ISSProcess
GO:0045087innate immune response19609254.19631370.IMPProcess
GO:0045087innate immune response-TASProcess
GO:0045944positive regulation of transcription by RNA polymerase II17079289.IDAProcess
GO:0051091positive regulation of DNA-binding transcription factor activity17079289.IDAProcess
GO:0051607defense response to virus21478870.IDAProcess
GO:0051607defense response to virus-TASProcess
GO:0060760positive regulation of response to cytokine stimulus21957149.IMPProcess
GO:0071360cellular response to exogenous dsRNA21957149.IMPProcess
GO:1902741positive regulation of interferon-alpha secretion21957149.IMPProcess
GO:1904469positive regulation of tumor necrosis factor secretion21957149.IMPProcess
GO:2000778positive regulation of interleukin-6 secretion21957149.IMPProcess
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