EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
16829125Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer.Crit Rev Oncol Hematol2006 SepDong Z-
25070653eIF3a is over-expressed in urinary bladder cancer and influences its phenotype independent of translation initiation.Cell Oncol (Dordr)2014 AugSpilka Rdoi: 10.1007/s13402-014-0181-9
20647036The translational regulator eIF3a: the tricky eIF3 subunit!Biochim Biophys Acta2010 DecSaletta Fdoi: 10.1016/j.bbcan.2010.07.005
23127338The A/G allele of eIF3a rs3740556 predicts platinum-based chemotherapy resistance in lung cancer patients.Lung Cancer2013 JanXu Xdoi: 10.1016/j.lungcan.2012.10.005
26213845eIF3a improve cisplatin sensitivity in ovarian cancer by regulating XPC and p27Kip1 translation.Oncotarget2015 Sep 22Zhang Ydoi: 10.18632/oncotarget.4555.
27333287Impact of a Eukaryotic Translation Initiation Factor 3a Polymorphism on Susceptibility to Gastric Cancer.Med Princ Pract2016Liu Kdoi: 10.1159/000447741

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr10119042728Missense_MutationnovelR931T0.13
BLCAchr10119042528Missense_Mutationrs369661440P998S0.39
BLCAchr10119069627Missense_MutationnovelH257D0.15
BLCAchr10119071002Nonsense_MutationnovelQ209*0.15
BLCAchr10119037271Missense_MutationnovelS1256C0.15
BLCAchr10119060066Intronnovel0.16
BLCAchr10119044062Silentrs144646420P913P0.38
BLCAchr10119049836Missense_MutationNAE875Q0.26
BLCAchr10119036140Missense_MutationNAE1350K0.27
BLCAchr10119037173Missense_MutationnovelL1289V0.5
BLCAchr10119065404Missense_MutationnovelD373N0.22
BLCAchr10119042683Missense_MutationNAR946T0.97
BLCAchr10119042390Missense_MutationnovelD1044N0.17
BLCAchr10119073809Missense_MutationnovelD60N0.65
BLCAchr10119070957Missense_MutationnovelE224Q0.07
BLCAchr10119058147Nonsense_MutationNAQ596*0.25
BRCAchr10119058184Missense_MutationNAE583D0.27
BRCAchr10119073833Silentrs138126632L52L0.41
BRCAchr101190340383'UTRnovel0.24
BRCAchr10119038373Missense_Mutationrs771425860S1198L0.16
BRCAchr10119042614Missense_MutationNAR969T0.7
BRCAchr10119036043Missense_MutationNAR1382H0.16
BRCAchr10119042048Missense_MutationNAP1158A0.25
BRCAchr10119051255Missense_MutationNAE755K0.11
CESCchr10119059904IntronNA0.21
CESCchr10119050625Missense_Mutationrs772554138R790Q0.32
CESCchr10119049941Missense_MutationnovelE840Q0.44
CESCchr10119060114IntronNA0.28
CESCchr10119036254Missense_Mutationrs775513192R1312C0.33
CESCchr10119042654Missense_Mutationrs144099570R956W0.27
CESCchr10119056800Silentrs780837333S712S0.37
CESCchr10119042762Missense_Mutationrs780944947R920C0.27
CESCchr10119051277Missense_MutationnovelK747N0.1
CESCchr10119073513Missense_MutationnovelE102G0.38
CESCchr10119038280Missense_MutationNAR1229T0.47
CESCchr101190353333'UTRnovel0.37
COADchr10119036146Nonsense_MutationNAE1348*0.35
COADchr10119042140Missense_MutationNAR1127I0.33
COADchr101190343433'UTRnovel0.32
COADchr10119042170Missense_Mutationrs768823906R1117Q0.23
COADchr10119058221Missense_MutationnovelR571H0.37
COADchr101190807745'UTRnovel0.21
COADchr101190360233'UTRnovel0.08
COADchr101190343343'UTRnovel0.2
COADchr10119042339Missense_MutationNAR1061C0.42
COADchr10119037156SilentNAD1294D0.17
COADchr10119073012Missense_MutationNAR140L0.27
COADchr10119050529Missense_MutationNAM822T0.07
COADchr10119036135Frame_Shift_DelNAE1352Rfs*430.4
COADchr10119065514Missense_Mutationrs755084308T336M0.12
COADchr10119065484Missense_MutationnovelG346V0.29
COADchr10119049850Missense_MutationnovelR870Q0.1
COADchr10119038312In_Frame_DelNAE1218del0.29
COADchr10119061283Missense_MutationNAL390I0.2
COADchr10119037127Missense_MutationNAR1304H0.11
COADchr10119042291Missense_Mutationrs375388729R1077W0.46
COADchr10119042380Missense_MutationNAG1047E0.51
COADchr10119042641Missense_Mutationrs775041698R960H0.27
COADchr10119059640Missense_Mutationrs770069171R469W0.31
COADchr101190342763'UTRnovel0.13
COADchr10119073776Missense_MutationnovelL71V0.09
COADchr10119051263Missense_MutationNAR752Q0.12
COADchr10119049822Silentrs201904104G879G0.31
COADchr10119056962Missense_MutationNAE686K0.29
COADchr10119069600Missense_MutationNAP266T0.34
COADchr10119072916Missense_MutationNAR172H0.34
COADchr101190338993'UTRnovel0.19
COADchr10119073045In_Frame_DelnovelL129del0.36
COADchr10119036199Missense_MutationnovelV1330A0.16
COADchr10119065517Missense_Mutationrs199796475R335H0.16
COADchr101190337783'UTRnovel0.17
COADchr10119059282Missense_MutationNAR520I0.27
COADchr101190342223'UTRnovel0.24
COADchr101190342053'UTRnovel0.06
COADchr10119073565Frame_Shift_InsnovelS85Pfs*100.05
DLBCchr10119065441SilentnovelG360G0.27
ESCAchr10119070998Missense_MutationnovelR210H0.22
ESCAchr10119058195Missense_MutationnovelE580K0.42
ESCAchr10119036262Missense_MutationnovelS1309Y0.19
GBMchr10119059250Missense_MutationnovelA531T0.11
GBMchr10119038345SilentnovelK1207K0.18
GBMchr10119042553Missense_MutationnovelW989C0.23
GBMchr10119042771Missense_MutationnovelE917K0.43
GBMchr10119058298Missense_MutationnovelE545D0.2
GBMchr10119069633Missense_MutationnovelD255Y0.04
GBMchr10119038317Nonsense_MutationnovelE1217*0.28
GBMchr10119056958Missense_MutationnovelR687H0.46
GBMchr10119059684Missense_MutationnovelR454H0.14
HNSCchr10119069625Silentrs759767366H257H0.2
HNSCchr10119038426SilentnovelE1180E0.16
HNSCchr10119058159Missense_MutationnovelE592K0.48
HNSCchr10119049851Missense_Mutationrs150064739R870W0.28
HNSCchr10119061286Missense_MutationnovelD389Y0.15
HNSCchr10119069627Missense_MutationnovelH257Y0.24
HNSCchr10119042647Missense_MutationnovelP958H0.27
HNSCchr10119037116Splice_Regionnovel0.36
HNSCchr10119049876SilentnovelR861R0.34
HNSCchr10119080637Missense_MutationnovelR14C0.58
KIRCchr10119073447Missense_MutationNAP124L0.77
KIRCchr10119037165Silentrs774454537D1291D0.24
LGGchr10119037240Silentrs773115498D1266D0.2
LGGchr10119042763Missense_MutationNAR919S0.06
LGGchr10119042644Missense_Mutationrs558278066R959Q0.42
LGGchr10119059244Missense_MutationnovelA533T0.28
LGGchr10119071043Missense_Mutationrs201828136R195H0.43
LGGchr10119073003Missense_MutationnovelR143K0.44
LIHCchr10119059637Missense_MutationNAA470T0.24
LIHCchr10119042046SilentNAP1158P0.47
LIHCchr10119069640SilentnovelA252A0.06
LIHCchr101190339433'UTRnovel0.4
LIHCchr10119042217SilentnovelR1101R0.14
LUADchr10119059603Missense_MutationnovelQ481L0.2
LUADchr10119042683Missense_MutationNAR946T0.43
LUADchr10119038332Missense_MutationNAD1212Y0.16
LUADchr10119073559Missense_MutationnovelE87Q0.14
LUADchr10119042057Missense_MutationNAD1155N0.38
LUADchr10119070946SilentnovelS227S0.24
LUADchr10119042576Frame_Shift_DelnovelA982Qfs*1910.18
LUADchr10119042672Missense_MutationNAL950F0.14
LUADchr10119051308Missense_MutationNAQ737L0.3
LUSCchr10119049947Nonsense_MutationnovelE838*0.28
LUSCchr10119070965Missense_MutationnovelN221I0.38
LUSCchr10119059357Missense_MutationnovelS495C0.06
LUSCchr10119044096Missense_MutationnovelG902E0.06
LUSCchr10119058232SilentnovelR567R0.34
LUSCchr10119036201SilentNAR1329R0.18
LUSCchr10119072911Missense_MutationNAY174H0.77
LUSCchr10119042547SilentNAN991N0.24
LUSCchr10119050638Nonsense_MutationnovelE786*0.25
LUSCchr10119037165Silentrs774454537D1291D0.18
LUSCchr10119050582SilentnovelI804I0.3
LUSCchr10119073445Missense_MutationNAE125K0.35
LUSCchr10119065430Missense_MutationnovelP364L0.32
LUSCchr10119042470Missense_MutationNAP1017Q0.14
LUSCchr10119042617Missense_MutationNAP968R0.04
OVchr10119058074Missense_MutationnovelE620V0.07
OVchr10119073919Frame_Shift_InsnovelK23Tfs*110.08
PAADchr10119071017Missense_MutationnovelH204Y0.2
PAADchr10119059297Missense_MutationnovelP515L0.21
READchr10119042080Missense_MutationNAR1147H0.19
READchr10119037215Missense_MutationNAR1275S0.46
READchr10119037218Missense_Mutationrs745913298R1274C0.05
READchr10119065421Missense_MutationnovelR367Q0.03
READchr10119037154Missense_MutationnovelR1295Q0.41
READchr10119042431Missense_Mutationrs138563024R1030Q0.38
READchr10119049962Missense_MutationnovelE833K0.08
READchr10119050585SilentnovelR803R0.44
READchr10119050625Missense_Mutationrs772554138R790Q0.23
READchr10119057980SilentnovelK651K0.08
SKCMchr10119057022Missense_MutationNAP666S0.64
SKCMchr10119058171Nonsense_MutationnovelQ588*0.39
SKCMchr10119041995Splice_RegionNAP1175P0.24
SKCMchr10119042594Missense_MutationnovelR976G0.21
SKCMchr10119042054Missense_Mutationrs754819756R1156W0.29
SKCMchr10119056813Missense_MutationnovelP708L0.42
SKCMchr10119042485Missense_Mutationrs372236521A1012V0.07
SKCMchr10119037201SilentnovelD1279D0.33
SKCMchr10119036194Missense_Mutationrs758241791P1332S0.16
SKCMchr10119042024Missense_Mutationrs769860513P1166S0.26
SKCMchr10119042527Missense_MutationNAP998L0.09
SKCMchr10119058237Nonsense_MutationNAQ566*0.24
SKCMchr10119065461Missense_MutationNAR354C0.22
SKCMchr10119044136Missense_MutationnovelR889G0.26
SKCMchr10119038254Missense_MutationNAR1238C0.34
SKCMchr10119059324Missense_Mutationrs535803217P506L0.89
SKCMchr10119059325Missense_MutationNAP506S0.88
SKCMchr10119073013Missense_MutationNAR140C0.57
SKCMchr10119042047Missense_MutationnovelP1158L0.22
SKCMchr10119042048Missense_MutationnovelP1158S0.21
SKCMchr10119073447Missense_MutationNAP124L0.54
SKCMchr10119051238SilentnovelF760F0.25
STADchr10119042661Silentrs148664870D953D0.36
STADchr10119065566Missense_MutationNAS319P0.34
STADchr10119050633Missense_MutationNAR787S0.33
STADchr10119059268Missense_MutationnovelA525S0.34
STADchr10119050589Missense_MutationNAR802H0.06
STADchr10119059347SilentNAN498N0.09
STADchr10119042714Missense_Mutationrs762013834R936W0.32
STADchr10119065514Missense_Mutationrs755084308T336M0.22
STADchr10119050601Missense_MutationNAR798H0.2
STADchr10119036091Missense_Mutationrs143903271R1366H0.09
STADchr10119049903Frame_Shift_DelnovelE853Kfs*3200.37
STADchr10119050603SilentNAQ797Q0.15
STADchr10119037179Nonsense_MutationNAR1287*0.35
STADchr10119038253Missense_MutationnovelR1238H0.42
TGCTchr10119061276Missense_MutationnovelN392S0.31
THCAchr10119038331Missense_MutationNAD1212V0.05
UCECchr10119049983Missense_Mutationrs762663906R826W0.23
UCECchr10119042584Missense_Mutationrs201081411R979H0.15
UCECchr10119036152Nonsense_MutationNAE1346*0.3
UCECchr10119042521Missense_Mutationrs757558927R1000Q0.34
UCECchr10119036047Nonsense_MutationNAR1381*0.15
UCECchr10119042340Missense_MutationnovelW1060C0.23
UCECchr10119036161Nonsense_Mutationrs763416725R1343*0.28
UCECchr10119036088Missense_Mutationrs764426395R1367H0.43
UCECchr10119042026Missense_MutationNAR1165I0.46
UCECchr10119042653Missense_MutationNAR956Q0.46
UCECchr10119050625Missense_Mutationrs772554138R790Q0.46
UCECchr10119058248Missense_MutationNAR562Q0.48
UCECchr10119050532Missense_MutationnovelQ821R0.81
UCECchr10119049962Missense_MutationnovelE833K0.21
UCECchr10119042024Missense_Mutationrs769860513P1166S0.43
UCECchr10119042607SilentnovelG971G0.38
UCECchr10119037214Missense_Mutationrs751921377R1275H0.42
UCECchr10119042068Missense_Mutationrs752397968R1151H0.09
UCECchr10119044062Silentrs144646420P913P0.36
UCECchr10119073543Missense_MutationnovelA92V0.41
UCECchr101190355823'UTRrs1896399900.52
UCECchr10119056959Missense_MutationnovelR687C0.23
UCECchr10119051243Missense_MutationNAL759V0.18
UCECchr10119042756Nonsense_MutationNAE922*0.22
UCECchr10119070945Missense_MutationnovelM228V0.11
UCECchr10119036172Missense_MutationNAR1339Q0.23
UCECchr10119042488Missense_MutationNAH1011R0.23
UCECchr10119042661Silentrs148664870D953D0.24
UCECchr10119080630Missense_MutationNAN16S0.24
UCECchr10119049848Missense_Mutationrs780272294R871C0.18
UCECchr10119069565SilentnovelN277N0.18
UCECchr10119042151Silentrs781737428A1123A0.51
UCECchr10119051210Missense_MutationnovelS770P0.08
UCECchr10119036088Missense_Mutationrs764426395R1367H0.39
UCECchr10119036202Missense_MutationnovelR1329L0.28
UCECchr10119051246Missense_MutationnovelD758Y0.34
UCECchr10119073783Missense_MutationnovelK68N0.42
UCECchr101190337833'UTRnovel0.18
UCECchr101190338893'UTRnovel0.2
UCECchr101190341173'UTRnovel0.23
UCECchr10119051199Missense_MutationnovelE773D0.07
UCECchr101190337423'UTRnovel0.21
UCECchr101190337313'UTRnovel0.28
UCECchr10119036047Nonsense_MutationNAR1381*0.53
UCECchr10119051264Nonsense_MutationnovelR752*0.32
UCECchr10119056985Missense_MutationnovelE678G0.3
UCECchr10119070978Missense_MutationnovelA217T0.36
UCECchr10119073020SilentnovelT137T0.41
UCECchr10119036256Missense_MutationNAR1311T0.38
UCECchr10119036088Missense_Mutationrs764426395R1367H0.54
UCECchr10119042513Missense_MutationnovelD1003N0.34
UCECchr10119071061Missense_Mutationrs182093925T189M0.43
UCECchr10119037299Missense_MutationnovelG1247S0.29
UCECchr10119058023Missense_MutationnovelR637Q0.35
UCECchr10119049822Silentrs201904104G879G0.48
UCECchr10119069503Missense_MutationnovelR298H0.44
UCECchr10119070902Missense_MutationnovelS242I0.48
UCECchr101190337783'UTRnovel0.19
UCECchr10119036047Nonsense_MutationNAR1381*0.43
UCECchr10119044072Missense_MutationnovelR910K0.48
UCECchr10119051213Nonsense_MutationNAQ769*0.38
UCECchr10119058120Missense_MutationNAR605W0.36
UCECchr10119059651Missense_MutationNAF465S0.41
UCECchr10119073566Missense_MutationnovelK84N0.22
UCECchr101190354503'UTRnovel0.12
UCECchr10119060803Missense_MutationNAE423D0.18
UCECchr10119073934Missense_MutationnovelF18C0.59
UCECchr101190339803'UTRnovel0.42
UCECchr101190352113'UTRnovel0.36
UCECchr101190359063'UTRnovel0.41
UCECchr10119042232SilentNAD1096D0.39
UCECchr10119058287Missense_MutationnovelQ549R0.26
UCECchr10119059610Missense_MutationnovelD479N0.28
UCECchr10119070980Missense_Mutationrs746446445T216M0.05
UCECchr10119042332Missense_MutationnovelA1063V0.46
UCECchr10119049968Missense_Mutationrs759307585R831C0.44
UCECchr10119059394Missense_Mutationrs758556287R483C0.41
UCECchr10119060091Intronnovel0.36
UCECchr10119065517Missense_Mutationrs199796475R335H0.24
UCECchr10119050623SilentNAL791L0.39
UCECchr10119036043Missense_MutationNAR1382H0.23
UCECchr10119042679SilentnovelE947E0.22
UCECchr10119056956Missense_MutationnovelL688I0.13
UCECchr10119042220SilentNAR1100R0.2
UCECchr10119042490SilentNAR1010R0.49
UCECchr10119071044Missense_MutationnovelR195C0.33
UCECchr10119050625Missense_Mutationrs772554138R790Q0.04
UCECchr10119042351Nonsense_MutationnovelR1057*0.19
UCECchr10119042654Missense_Mutationrs144099570R956W0.46
UCECchr10119059675Missense_MutationnovelS457Y0.15
UCECchr10119072925Missense_MutationnovelR169I0.21
UCECchr10119073782Missense_MutationnovelE69K0.19
UCECchr101190359793'UTRnovel0.48
UCECchr101190807435'UTRnovel0.5
UCECchr10119037212Missense_MutationnovelE1276K0.45
UCECchr10119069595SilentnovelP267P0.2
UCECchr10119070990Missense_MutationnovelN213D0.51
UCECchr101190351953'UTRnovel0.48
UCECchr10119036241Missense_MutationnovelR1316K0.36
UCECchr101190339743'UTRnovel0.38
UCSchr10119056951Silentrs767275902K689K0.33
UCSchr10119060124Intronnovel0.37

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.10.19593
CHOLDEL0.27780.048655
COADDEL0.15529.4741e-07
LGGDEL0.26124.3789e-20
LIHCDEL0.24865.7505e-06
MESODEL0.28740.00015289
OVDEL0.30575.3759e-12
PAADDEL0.11410.169
READDEL0.20.014135
THYMDEL0.03250.10563
UCSDEL0.28570.1218

Survival Analysis
CancerP-value Q-value
KIRC0.00011

Kaplan-Meier Survival Analysis

ACC0.0028

Kaplan-Meier Survival Analysis

PRAD0.046

Kaplan-Meier Survival Analysis

LUSC0.041

Kaplan-Meier Survival Analysis

PAAD0.031

Kaplan-Meier Survival Analysis

BLCA0.019

Kaplan-Meier Survival Analysis

LAML0.0034

Kaplan-Meier Survival Analysis

GBM0.048

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.022

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000107581 (Gene tree)
Gene ID
8661
Gene Symbol
EIF3A
Alias
eIF3-theta|eIF3-p170|KIAA0139|eIF3a|TIF32|EIF3|EIF3S10
Full Name
eukaryotic translation initiation factor 3 subunit A
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
47,154 bases
Position
chr10:119,033,670-119,080,823
Accession
3271
RBP type
non-canonical RBP
Summary
(Eukaryotic Translation Initiation Factor 3 Subunit A) is a Protein Coding gene. Diseases associated with EIF3A include Brachydactyly, Type E1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
11022043Mutually cooperative binding of eukaryotic translation initiation factor (eIF) 3 and eIF4A to human eIF4G-1.J Biol Chem2000 Dec 29Korneeva NL-
7542616GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.Genes Dev1995 Jul 15Garcia-Barrio MT-
10212941Replication of tobacco mosaic virus RNA.Philos Trans R Soc Lond B Biol Sci1999 Mar 29Buck KW-
23766293Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation.Nucleic Acids Res2013 AugSun Cdoi: 10.1093/nar/gkt510
10085088Characterization of the p33 subunit of eukaryotic translation initiation factor-3 from Saccharomyces cerevisiae.J Biol Chem1999 Mar 26Hanachi P-
9341143Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.J Biol Chem1997 Oct 24Asano K-
7798228Purified yeast translational initiation factor eIF-3 is an RNA-binding protein complex that contains the PRT1 protein.J Biol Chem1994 Dec 23Naranda T-
19835415How does a scanning ribosomal particle move along the 5'-untranslated region of eukaryotic mRNA? Brownian Ratchet model.Biochemistry2009 Nov 17Spirin ASdoi: 10.1021/bi901379a.
17445855Foot-and-mouth disease virus infection induces proteolytic cleavage of PTB, eIF3a,b, and PABP RNA-binding proteins.Virology2007 Aug 1Rodriguez Pulido M-
22123745The eIF3c/NIP1 PCI domain interacts with RNA and RACK1/ASC1 and promotes assembly of translation preinitiation complexes.Nucleic Acids Res2012 MarKouba Tdoi: 10.1093/nar/gkr1083
20862284Crystal structure of the RNA recognition motif of yeast translation initiation factor eIF3b reveals differences to human eIF3b.PLoS One2010 Sep 16Khoshnevis Sdoi: 10.1371/journal.pone.0012784.
20816988Distinct regions of human eIF3 are sufficient for binding to the HCV IRES and the 40S ribosomal subunit.J Mol Biol2010 Oct 22Cai Qdoi: 10.1016/j.jmb.2010.07.054
24423867Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes.Nucleic Acids Res2014 AprKhoshnevis Sdoi: 10.1093/nar/gkt1369
28138064Human eIF3: from 'blobology' to biological insight.Philos Trans R Soc Lond B Biol Sci2017 Mar 19Cate JHdoi: 10.1098/rstb.2016.0176.
25849773eIF3 targets cell-proliferation messenger RNAs for translational activation or repression.Nature2015 Jun 4Lee ASdoi: 10.1038/nature14267
31088929Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae.MBio2019 May 14Anderson DEdoi: 10.1128/mBio.00826-19.
24965446Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.J Virol2014 SepJefferson Mdoi: 10.1128/JVI.00984-14
18977752Translation initiation factor 4B homodimerization, RNA binding, and interaction with Poly(A)-binding protein are enhanced by zinc.J Biol Chem2008 Dec 26Cheng Sdoi: 10.1074/jbc.M807716200
11233977Mechanism of ribosome recruitment by hepatitis C IRES RNA.RNA2001 FebKieft JS-
10648778Influence of correct secondary and tertiary RNA folding on the binding of cellular factors to the HCV IRES.Nucleic Acids Res2000 Feb 15Odreman-Macchioli FE-
29136179Fluorescently-tagged human eIF3 for single-molecule spectroscopy.Nucleic Acids Res2018 Jan 25Johnson AGdoi: 10.1093/nar/gkx1050.
9573242Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs.J Virol1998 JunSizova DV-
11927953Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation.Nat Struct Biol2002 MayKieft JS-
11927954A conserved RNA structure within the HCV IRES eIF3-binding site.Nat Struct Biol2002 MayCollier AJ-
11179233Related eIF3 subunits TIF32 and HCR1 interact with an RNA recognition motif in PRT1 required for eIF3 integrity and ribosome binding.EMBO J2001 Feb 15Valasek L-
16322461Structural roles for human translation factor eIF3 in initiation of protein synthesis.Science2005 Dec 2Siridechadilok B-
19114715MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation.J Biol Chem2009 Mar 6Unhavaithaya Ydoi: 10.1074/jbc.M809104200
17921501Targeted inhibition of the hepatitis C internal ribosomal entry site genomic RNA with oligonucleotide conjugates.Nucleic Acids Res2007Guerniou V-
23921387Spectrin domain of eukaryotic initiation factor 3a is the docking site for formation of the a:b:i:g subcomplex.J Biol Chem2013 Sep 27Dong Zdoi: 10.1074/jbc.M113.483164
24278036Translation initiation factors eIF3 and HCR1 control translation termination and stop codon read-through in yeast cells.PLoS Genet2013 NovBeznoskova Pdoi: 10.1371/journal.pgen.1003962
27462815eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.Nature2016 Aug 4Lee AS-
30684270A 54-kDa short variant of DHX33 functions in regulating mRNA translation.J Cell Physiol2019 Jan 26Su Ddoi: 10.1002/jcp.28178
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000541549EIF3A-2034495-ENSP000004381781382 (aa)-Q14152
ENST00000369144EIF3A-2016646-ENSP000003581401382 (aa)-Q14152
ENST00000462527EIF3A-2021192--- (aa)--
Gene Model
Click here to download ENSG00000107581's gene model file
Pathways
Pathway IDPathway NameSource
hsa03013RNA transportKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000107581Albuminuria3.85433975361434E-1717903292
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000107581rs7647391310119063394CDisease progression in age-related macular degeneration293466441.5EFO_0001365|EFO_0008336
ENSG00000107581rs1078790310119064457?Alcoholic chronic pancreatitis28754779[1.16-1.36]1.2575EFO_1002013
ENSG00000107581rs11761958010119075359?Alcoholic chronic pancreatitis28754779[1.39-2.20]1.7531557EFO_1002013
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000107581's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000107581EIF3A5838.941WBGene00001209egl-457438.647Caenorhabditis_elegans
ENSG00000107581EIF3A10076.525ENSDARG00000076815eif3s109276.322Danio_rerio
ENSG00000107581EIF3A7746.387FBgn0037249eIF3a7051.572Drosophila_melanogaster
ENSG00000107581EIF3A10091.486ENSMUSG00000024991Eif3a10092.857Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001732formation of cytoplasmic translation initiation complex21873635.IBAProcess
GO:0001732formation of cytoplasmic translation initiation complex17581632.IDAProcess
GO:0002188translation reinitiation21873635.IBAProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003723RNA binding25849773.27462815.IDAFunction
GO:0003729mRNA binding21873635.IBAFunction
GO:0003743translation initiation factor activity21873635.IBAFunction
GO:0003743translation initiation factor activity17322308.18599441.ICFunction
GO:0003743translation initiation factor activity17581632.25849773.IDAFunction
GO:0005198structural molecule activity9150439.NASFunction
GO:0005515protein binding11169732.14688252.17468741.18423202.18599441.18628297.19245811.21124883.22190034.23623729.IPIFunction
GO:0005634nucleus-IDAComponent
GO:0005730nucleolus-IDAComponent
GO:0005737cytoplasm9150439.NASComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005852eukaryotic translation initiation factor 3 complex17322308.17581632.18599441.25849773.IDAComponent
GO:0005874microtubule-IEAComponent
GO:0006413translational initiation17322308.18599441.ICProcess
GO:0006413translational initiation-TASProcess
GO:0014069postsynaptic density-IEAComponent
GO:0016020membrane19946888.HDAComponent
GO:0016282eukaryotic 43S preinitiation complex-IEAComponent
GO:0030971receptor tyrosine kinase binding-IEAFunction
GO:0033290eukaryotic 48S preinitiation complex-IEAComponent
GO:0043614multi-eIF complex21873635.IBAComponent
GO:0070373negative regulation of ERK1 and ERK2 cascade-IEAProcess
GO:0071540eukaryotic translation initiation factor 3 complex, eIF3e21873635.IBAComponent
GO:0071541eukaryotic translation initiation factor 3 complex, eIF3m21873635.IBAComponent
GO:0075522IRES-dependent viral translational initiation9573242.23766293.24357634.IDAProcess
GO:0075525viral translational termination-reinitiation21347434.IDAProcess
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