EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27995408	High Expression of BCCIP β Can Promote Proliferation of Esophageal Squamous Cell Carcinoma.	Dig Dis Sci	2017 Feb	Chen L	doi: 10.1007/s10620-016-4382-0
28394342	Regulation of spindle integrity and mitotic fidelity by BCCIP.	Oncogene	2017 Aug 17	Huhn SC	doi: 10.1038/onc.2017.92
28510697	BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction.	J Mol Cell Biol	2017 Jun 1	Ba Q	doi: 10.1093/jmcb/mjx019.
29047390	Roles of BCCIP deficiency in mammary tumorigenesis.	Breast Cancer Res	2017 Oct 18	Droz-Rosario R	doi: 10.1186/s13058-017-0907-5.
11836363	Unique de novo mutation of BRCA2 in a woman with early onset breast cancer.	J Med Genet	2002 Feb	Robson M	-
11754111	BRCA2 gene mutations in Greek patients with familial breast cancer.	Hum Mutat	2002 Jan	Armakolas A	-
23911796	Mutation analysis of the BCCIP gene for breast cancer susceptibility in breast/ovarian cancer families.	Gynecol Oncol	2013 Nov	Bonache S	doi: 10.1016/j.ygyno.2013.07.104

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr10	125823665	Silent	novel	D36D	0.58
BLCA	chr10	125836310	3'UTR	novel		0.59
BLCA	chr10	125841372	3'Flank	novel		0.1
BLCA	chr10	125831466	Missense_Mutation	novel	C153Y	0.15
BLCA	chr10	125823678	Missense_Mutation	novel	D41N	0.35
BLCA	chr10	125853276	3'UTR	novel		0.52
BRCA	chr10	125833785	Missense_Mutation	rs544090028	G205R	0.31
BRCA	chr10	125841410	3'Flank	rs768326454		0.09
BRCA	chr10	125853274	3'UTR	novel		0.08
BRCA	chr10	125833784	Frame_Shift_Del	novel	*A206Hfs16**	0.08
BRCA	chr10	125853188	Nonsense_Mutation	novel	S305*	0.11
BRCA	chr10	125833772	Missense_Mutation	novel	Q200H	0.05
BRCA	chr10	125830602	Missense_Mutation	NA	E121A	0.16
BRCA	chr10	125853380	3'UTR	novel		0.18
BRCA	chr10	125853381	3'UTR	novel		0.18
BRCA	chr10	125830575	Missense_Mutation	NA	S112L	0.22
BRCA	chr10	125853235	Missense_Mutation	novel	L321V	0.41
CESC	chr10	125830604	In_Frame_Del	novel	D122del	0.21
CESC	chr10	125836192	Missense_Mutation	rs140510480	T288M	0.23
CESC	chr10	125823608	Frame_Shift_Ins	novel	*P18Tfs18**	0.02
CESC	chr10	125827564	Missense_Mutation	novel	L83V	0.58
COAD	chr10	125823648	Nonsense_Mutation	novel	E31*	0.12
COAD	chr10	125831532	Missense_Mutation	novel	P175H	0.46
COAD	chr10	125853155	Missense_Mutation	novel	V294G	0.55
COAD	chr10	125841976	Intron	novel		0.46
COAD	chr10	125830565	Missense_Mutation	novel	T109A	0.29
ESCA	chr10	125830628	Missense_Mutation	rs757615170	L130V	0.08
ESCA	chr10	125836270	Nonsense_Mutation	novel		0.24
GBM	chr10	125853338	3'UTR	novel		0.07
GBM	chr10	125841957	Intron	novel		0.38
GBM	chr10	125841473	3'Flank	novel		0.54
HNSC	chr10	125823581	Silent	novel	R8R	0.15
HNSC	chr10	125830575	Missense_Mutation	NA	S112L	0.1
HNSC	chr10	125823580	Missense_Mutation	novel	R8L	0.29
KIRC	chr10	125831584	Silent	NA	A192A	0.16
KIRP	chr10	125823607	Missense_Mutation	novel	P17L	0.54
KIRP	chr10	125826598	Missense_Mutation	novel	N58I	0.2
LGG	chr10	125841985	Intron	novel		0.12
LGG	chr10	125836262	Frame_Shift_Ins	novel	*L312Yfs28**	0.09
LGG	chr10	125836263	Frame_Shift_Ins	novel	*L312Rfs32**	0.09
LUAD	chr10	125836318	3'UTR	novel		0.18
LUAD	chr10	125823711	Missense_Mutation	novel	V52L	0.07
LUSC	chr10	125836152	Missense_Mutation	NA	C275S	0.14
LUSC	chr10	125833851	Missense_Mutation	novel	V227L	0.07
LUSC	chr10	125836115	Silent	rs750445786	L262L	0.05
LUSC	chr10	125841318	3'Flank	NA		0.16
LUSC	chr10	125831573	Missense_Mutation	novel	P189T	0.13
LUSC	chr10	125853194	Missense_Mutation	novel	L307P	0.33
OV	chr10	125853377	3'UTR	novel		0.13
PAAD	chr10	125827597	Missense_Mutation	novel	D94Y	0.2
PAAD	chr10	125853272	3'UTR	novel		0.2
PRAD	chr10	125823576	Missense_Mutation	rs138579130	R7G	0.19
READ	chr10	125853249	3'UTR	novel		0.28
SARC	chr10	125853158	Missense_Mutation	novel	S295C	0.38
SKCM	chr10	125831444	Nonsense_Mutation	NA	Q146*	0.43
SKCM	chr10	125831545	Silent	NA	L179L	0.48
SKCM	chr10	125831581	Silent	rs143179971	I191I	0.32
STAD	chr10	125831502	Missense_Mutation	novel	L165R	0.26
STAD	chr10	125831594	Missense_Mutation	novel	Y196H	0.42
STAD	chr10	125853252	3'UTR	novel		0.28
STAD	chr10	125836235	Silent	rs772560768	N302N	0.35
STAD	chr10	125841711	Intron	novel		0.28
STAD	chr10	125836184	Silent	NA	V285V	0.33
STAD	chr10	125841377	3'Flank	novel		0.11
TGCT	chr10	125836328	3'UTR	novel		0.21
THCA	chr10	125823703	Frame_Shift_Ins	novel	*D50Afs10**	0.05
UCEC	chr10	125833932	Nonsense_Mutation	NA	E254*	0.33
UCEC	chr10	125841660	Intron	novel		0.35
UCEC	chr10	125853250	3'UTR	novel		0.45
UCEC	chr10	125833872	Missense_Mutation	novel	S234P	0.3
UCEC	chr10	125823719	Silent	novel	D54D	0.48
UCEC	chr10	125836236	Missense_Mutation	NA	E303K	0.37
UCEC	chr10	125853148	Missense_Mutation	novel	A292S	0.34
UCEC	chr10	125853380	3'UTR	novel		0.1
UCEC	chr10	125853381	3'UTR	novel		0.1
UCEC	chr10	125827561	Missense_Mutation	NA	F82V	0.42
UCEC	chr10	125841661	Intron	novel		0.3
UCEC	chr10	125853377	3'UTR	novel		0.18
UCEC	chr10	125853377	3'UTR	novel		0.11
UCEC	chr10	125823648	Nonsense_Mutation	novel	E31*	0.51
UCEC	chr10	125823648	Nonsense_Mutation	novel	E31*	0.46
UCEC	chr10	125831473	Missense_Mutation	NA	K155N	0.4
UCEC	chr10	125833896	Missense_Mutation	rs78371050	K242Q	0.31
UCEC	chr10	125836236	Missense_Mutation	NA	E303K	0.36
UCEC	chr10	125842785	Intron	novel		0.45
UCEC	chr10	125823695	Missense_Mutation	rs182757952	K46N	0.31
UCEC	chr10	125841718	Intron	novel		0.2
UCEC	chr10	125826590	Splice_Site	novel	X56_splice	0.48
UCEC	chr10	125833849	Missense_Mutation	novel	F226C	0.61
UCEC	chr10	125836236	Missense_Mutation	NA	E303K	0.52
UCEC	chr10	125831485	Missense_Mutation	novel	K159N	0.31
UCEC	chr10	125836253	Silent	novel	L308L	0.35
UCEC	chr10	125841710	Intron	rs746110433		0.31
UCEC	chr10	125833907	Silent	rs140341325	A245A	0.26
UCEC	chr10	125841711	Intron	novel		0.27
UCEC	chr10	125853299	3'UTR	novel		0.3
UCEC	chr10	125853296	3'UTR	rs555755243		0.45
UCEC	chr10	125841273	3'Flank	NA		0.43
UCEC	chr10	125836235	Silent	rs772560768	N302N	0.33
UCEC	chr10	125842005	Intron	novel		0.33
UCEC	chr10	125836191	Missense_Mutation	NA	T288S	0.29
UCEC	chr10	125841945	Intron	novel		0.17
UCEC	chr10	125827597	Missense_Mutation	novel	D94N	0.37
UCEC	chr10	125826591	Missense_Mutation	novel	E56K	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1111	0.19593
CHOL	DEL	0.1944	0.048655
COAD	DEL	0.1596	9.4741e-07
LGG	DEL	0.2671	4.3789e-20
LIHC	DEL	0.2405	5.7505e-06
MESO	DEL	0.2644	0.00015289
PAAD	DEL	0.1141	0.169
READ	DEL	0.2061	0.014135
THYM	DEL	0.0325	0.10563
UCS	DEL	0.25	0.1218

Survival Analysis

Cancer	P-value	Q-value
STAD	0.021	Kaplan-Meier Survival Analysis
SARC	0.0048	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
UCS	0.049	Kaplan-Meier Survival Analysis
HNSC	0.034	Kaplan-Meier Survival Analysis
SKCM	0.016	Kaplan-Meier Survival Analysis
PRAD	0.016	Kaplan-Meier Survival Analysis
ESCA	0.027	Kaplan-Meier Survival Analysis
KIRP	0.01	Kaplan-Meier Survival Analysis
CESC	0.024	Kaplan-Meier Survival Analysis
UCEC	0.047	Kaplan-Meier Survival Analysis
LIHC	0.0034	Kaplan-Meier Survival Analysis
CHOL	0.0036	Kaplan-Meier Survival Analysis
UVM	0.0056	Kaplan-Meier Survival Analysis
OV	0.011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000107949 (Gene tree)
Gene ID: 56647
Gene Symbol: BCCIP
Alias: BCCIPalpha|TOK-1
Full Name: BRCA2 and CDKN1A interacting protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 30,161 bases
Position: chr10:125,823,535-125,853,695
Accession: 978
RBP type: non-canonical RBP
Summary: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17135243	Abrogation of the transactivation activity of p53 by BCCIP down-regulation.	J Biol Chem	2007 Jan 19	Meng X	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000278100	BCCIP-201	1236	-	ENSP00000278100	314 (aa)	-	Q9P287
ENST00000478798	BCCIP-205	1461	-	-	- (aa)	-	-
ENST00000368759	BCCIP-203	1433	-	ENSP00000357748	322 (aa)	-	Q9P287
ENST00000463330	BCCIP-204	500	-	-	- (aa)	-	-
ENST00000299130	BCCIP-202	2337	-	ENSP00000299130	292 (aa)	-	Q9P287

Gene Model

Click here to download ENSG00000107949's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000107949	Body Mass Index	9.9260000E-005	-
ENSG00000107949	Waist Circumference	3.6680000E-005	-
ENSG00000107949	Arteries	7.4650000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	EFO ID
ENSG00000107949	rs11244669	10	125844213	?	Red cell distribution width	30595370	EFO_0005192
ENSG00000107949	rs11244669	10	125844213	?	Mean corpuscular hemoglobin	30595370	EFO_0004527
ENSG00000107949	rs11244669	10	125844213	?	Red blood cell count	30595370	EFO_0004305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000107949's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000055	ribosomal large subunit export from nucleus	21873635.	IBA	Process
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	21873635.	IBA	Process
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	10878006.	IDA	Process
GO:0000132	establishment of mitotic spindle orientation	21873635.	IBA	Process
GO:0000226	microtubule cytoskeleton organization	28394342.	IMP	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	16189514.18440304.25416956.28931820.	IPI	Function
GO:0005634	nucleus	10878006.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005813	centrosome	28394342.	IDA	Component
GO:0005814	centriole	21873635.	IBA	Component
GO:0005814	centriole	28394342.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0006974	cellular response to DNA damage stimulus	21873635.	IBA	Process
GO:0007052	mitotic spindle organization	21873635.	IBA	Process
GO:0007052	mitotic spindle organization	28394342.	IMP	Process
GO:0015631	tubulin binding	21873635.	IBA	Function
GO:0019207	kinase regulator activity	21873635.	IBA	Function
GO:0019207	kinase regulator activity	10878006.	IDA	Function
GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	21873635.	IBA	Component
GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex	10878006.	IDA	Component
GO:0034453	microtubule anchoring	21873635.	IBA	Process
GO:0034453	microtubule anchoring	28394342.	IMP	Process
GO:0061101	neuroendocrine cell differentiation	18440304.	IDA	Process
GO:0090307	mitotic spindle assembly	21873635.	IBA	Process
GO:0090307	mitotic spindle assembly	28394342.	IMP	Process
GO:0097431	mitotic spindle pole	21873635.	IBA	Component
GO:0097431	mitotic spindle pole	28394342.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.