EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
18757437Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma.Cancer Res2008 Sep 1Fogal Vdoi: 10.1158/0008-5472.CAN-07-6752.
22771308Significance of hyaluronan binding protein (HABP1/P32/gC1qR) expression in advanced serous ovarian cancer patients.Exp Mol Pathol2013 FebYu Gdoi: 10.1016/j.yexmp.2012.06.007
25794640Elevated expression of HABP1 is a novel prognostic indicator in triple-negative breast cancers.Tumour Biol2015 JunWang Jdoi: 10.1007/s13277-015-3131-x
21205079Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy.Cancer Sci2011 MarAmamoto Rdoi: 10.1111/j.1349-7006.2010.01828.x
21627988Hyaluronan-binding protein 1 (HABP1/p32/gC1qR) induces melanoma cell migration and tumor growth by NF-kappa B dependent MMP-2 activation through integrin α(v)β(3) interaction.Cell Signal2011 OctPrakash Mdoi: 10.1016/j.cellsig.2011.04.009
25061661Increased hyaluronan levels in HABP1/p32/gC1qR overexpressing HepG2 cells inhibit autophagic vacuolation regulating tumor potency.PLoS One2014 Jul 25Saha Pdoi: 10.1371/journal.pone.0103208
21156793The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies.J Biol Chem2011 Feb 18S??nchez-Mart??n Ddoi: 10.1074/jbc.M110.161927
21725590The role of gC1qR in regulating survival of human papillomavirus 16 oncogene-transfected cervical cancer cells.Int J Oncol2011 NovGao LJdoi: 10.3892/ijo.2011.1108
19565630Increased expression of hyaluronic acid binding protein 1 is correlated with poor prognosis in patients with breast cancer.J Surg Oncol2009 Oct 1Chen YBdoi: 10.1002/jso.21329.
23924515Interactome analysis reveals that C1QBP (complement component 1, q subcomponent binding protein) is associated with cancer cell chemotaxis and metastasis.Mol Cell Proteomics2013 NovZhang Xdoi: 10.1074/mcp.M113.029413
22101277The mitochondrial protein C1qbp promotes cell proliferation, migration and resistance to cell death.Cell Cycle2011 Dec 1McGee AMdoi: 10.4161/cc.10.23.18287
25355598Overexpression of HABP1 correlated with clinicopathological characteristics and unfavorable prognosis in endometrial cancer.Tumour Biol2015 FebZhao Jdoi: 10.1007/s13277-014-2761-8
25573962Complement component 1, q subcomponent binding protein is a marker for proliferation in breast cancer.Exp Biol Med (Maywood)2015 JulScully OJdoi: 10.1177/1535370214565075
20100866Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation.Mol Cell Biol2010 MarFogal Vdoi: 10.1128/MCB.01101-09
25497084C1QBP negatively regulates the activation of oncoprotein YBX1 in the renal cell carcinoma as revealed by interactomics analysis.J Proteome Res2015 Feb 6Wang Ydoi: 10.1021/pr500847p
28039537Hyaluronic acid binding protein 1 overexpression is an indicator for disease-free survival in cervical cancer.Int J Clin Oncol2017 AprZhang Mdoi: 10.1007/s10147-016-1077-7
28108744Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women.Oncotarget2017 Feb 21Jiang Ydoi: 10.18632/oncotarget.14737.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr175433358Missense_MutationNAQ212E0.25
BLCAchr175434884Nonsense_MutationnovelE156*0.44
BRCAchr1754330103'UTRnovel0.68
CESCchr175438845Missense_MutationNAD77N0.29
CESCchr175433401Silentrs184461242D197D0.09
CHOLchr175438240Missense_MutationnovelE89A0.36
COADchr1754330013'UTRnovel0.44
COADchr175438154Missense_MutationnovelA118T0.38
COADchr175433132SilentnovelA244A0.06
DLBCchr175433032Missense_MutationnovelF278V0.25
GBMchr175434900Silentrs535657744S150S0.41
GBMchr175434889Missense_MutationnovelK154T0.07
GBMchr175433055Missense_MutationnovelT270N0.05
HNSCchr175433741Silentrs774258991F168F0.31
HNSCchr175433127Missense_MutationnovelR246Q0.13
LUSCchr175433764Missense_MutationNAE161K0.41
MESOchr175439064SilentnovelL4L0.23
MESOchr175438931Missense_MutationnovelV48E0.17
OVchr175438131SilentNAA125A0.09
PAADchr175433328Missense_MutationnovelT222A0.19
SKCMchr175434951SilentNAF133F0.3
SKCMchr175434928Missense_MutationNAP141L0.27
STADchr175433740Missense_Mutationrs371917632V169M0.19
STADchr175434935Missense_MutationNAI139V0.1
TGCTchr175433318Missense_MutationnovelT225I0.07
UCECchr175438210Missense_MutationnovelH99R0.4
UCECchr175438164SilentNAN114N0.42
UCECchr1754329523'UTRnovel0.43
UCECchr175438261Missense_MutationNAF82S0.15
UCECchr175433050Missense_MutationnovelL272I0.21
UCECchr175438152SilentnovelA118A0.36
UCECchr175433349Missense_Mutationrs115819590G215S0.41
UCECchr175433021SilentnovelS281S0.29
UCECchr175433315Missense_MutationnovelL226P0.19
UCECchr175433756SilentnovelT163T0.23
UCECchr175433383SilentNAI203I0.21
UCECchr175438202Missense_MutationnovelL102I0.42
UCECchr1754330113'UTRnovel0.37
UCSchr175434875Missense_MutationnovelE159K0.08

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.20830.18166
LAMLDEL0.07330.12511
LIHCDEL0.55683.9592e-10
THCADEL0.0160.221

Survival Analysis
CancerP-value Q-value
KIRC0.029

Kaplan-Meier Survival Analysis

SARC0.0042

Kaplan-Meier Survival Analysis

PRAD0.03

Kaplan-Meier Survival Analysis

PAAD0.032

Kaplan-Meier Survival Analysis

KICH0.0058

Kaplan-Meier Survival Analysis

CHOL0.0014

Kaplan-Meier Survival Analysis

LUAD0.0047

Kaplan-Meier Survival Analysis

UVM0.0037

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000108561 (Gene tree)
Gene ID
708
Gene Symbol
C1QBP
Alias
HABP1|P32
Full Name
Complement C1q Binding Protein
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
16,054 bases
Position
chr17:5,432,777-5,448,830
Accession
1243
RBP type
non-canonical RBP
Summary
The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
10022843The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation.EMBO J1999 Feb 15Petersen-Mahrt SK-
9678487Physical association between the EBV protein EBNA-1 and P32/TAP/hyaluronectin.J Biomed Sci1998Chen MR-
10823864Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria.J Virol2000 JunBeatch MD-
16641292Cellular splicing and transcription regulatory protein p32 represses adenovirus major late transcription and causes hyperphosphorylation of RNA polymerase II.J Virol2006 MayOhrmalm C-
22904065p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability.Nucleic Acids Res2012 OctYagi Mdoi: 10.1093/nar/gks774
17698161Analysis of the selective advantage conferred by a C-E1 fusion protein synthesized by rubella virus DI RNAs.Virology2007 Dec 5Claus C-
21920408The role of TFAM-associated proteins in mitochondrial RNA metabolism.Biochim Biophys Acta2012 MayUchiumi Tdoi: 10.1016/j.bbagen.2011.08.014
23947187[The functional and pathological analysis of mitochondrial protein p32].Rinsho Byori2013 JunUchiumi T-
26385742Interactions between RNA-binding proteins and P32 homologues in trypanosomes and human cells.Curr Genet2016 FebPolledo JMdoi: 10.1007/s00294-015-0519-5
26816005Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.PLoS One2016 Jan 27Ansseau Edoi: 10.1371/journal.pone.0146893
27814609Mitochondrial nucleic acid binding proteins associated with diseases.Front Biosci (Landmark Ed)2017 Jan 1Uchiumi T-
15163734Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt.J Virol2004 JunYao ZQ-
25354864[Expression of C1QBP gene and its correlation with drug resistance in human resistance choriocarcinoma cell line].Zhonghua Fu Chan Ke Za Zhi2014 AugShen X-
11812855The trypanosome homolog of human p32 interacts with RBP16 and stimulates its gRNA binding activity.Nucleic Acids Res2001 Dec 15Hayman ML-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000576122C1QBP-207383-ENSP000004586249 (aa)-A0A0G2JLC0
ENST00000573406C1QBP-204767--- (aa)--
ENST00000574444C1QBP-206901-ENSP00000460308178 (aa)-I3L3B0
ENST00000225698C1QBP-2011169-ENSP00000225698282 (aa)-Q07021
ENST00000573421C1QBP-205330--- (aa)--
ENST00000570805C1QBP-202688-ENSP00000460638177 (aa)-I3L3Q7
ENST00000573204C1QBP-203911--- (aa)--
Gene Model
Click here to download ENSG00000108561's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108561's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II15243141.IDAProcess
GO:0001849complement component C1q binding21873635.IBAFunction
GO:0001849complement component C1q binding8195709.IDAFunction
GO:0003714transcription corepressor activity21873635.IBAFunction
GO:0003714transcription corepressor activity15243141.IDAFunction
GO:0003729mRNA binding21873635.IBAFunction
GO:0003729mRNA binding-ISSFunction
GO:0005080protein kinase C binding-IEAFunction
GO:0005515protein binding8710908.8900153.10831594.11086025.12034482.15031724.16721827.17486078.18191643.18676636.19164550.22118625.22238231.23986595.24955142.25497084.25852190.28018340.IPIFunction
GO:0005540hyaluronic acid binding21873635.IBAFunction
GO:0005540hyaluronic acid binding8567680.IDAFunction
GO:0005615extracellular space-IEAComponent
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus15243141.IDAComponent
GO:0005730nucleolus-IEAComponent
GO:0005737cytoplasm-ISSComponent
GO:0005739mitochondrion21873635.IBAComponent
GO:0005739mitochondrion11083468.19164550.IDAComponent
GO:0005759mitochondrial matrix-IEAComponent
GO:0005829cytosol15243141.IDAComponent
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane-IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0006397mRNA processing-IEAProcess
GO:0006915apoptotic process-IEAProcess
GO:0006955immune response8195709.TASProcess
GO:0006958complement activation, classical pathway-IEAProcess
GO:0007597blood coagulation, intrinsic pathway-TASProcess
GO:0008134transcription factor binding21873635.IBAFunction
GO:0008134transcription factor binding15243141.IDAFunction
GO:0008380RNA splicing-IEAProcess
GO:0008494translation activator activity21873635.IBAFunction
GO:0009986cell surface21873635.IBAComponent
GO:0009986cell surface17881511.IDAComponent
GO:0014065phosphatidylinositol 3-kinase signaling16177118.IMPProcess
GO:0016020membrane8662673.11290596.IDAComponent
GO:0016032viral process-IEAProcess
GO:0030449regulation of complement activation21873635.IBAProcess
GO:0030449regulation of complement activation8195709.IDAProcess
GO:0030984kininogen binding21873635.IBAFunction
GO:0030984kininogen binding8662673.IDAFunction
GO:0031690adrenergic receptor binding-ISSFunction
GO:0032689negative regulation of interferon-gamma production17881511.IDAProcess
GO:0032695negative regulation of interleukin-12 production16177118.17881511.IDAProcess
GO:0039534negative regulation of MDA-5 signaling pathway19164550.IDAProcess
GO:0039536negative regulation of RIG-I signaling pathway19164550.IDAProcess
GO:0042256mature ribosome assembly21873635.IBAProcess
GO:0042256mature ribosome assembly21536856.IMPProcess
GO:0043065positive regulation of apoptotic process15031724.IMPProcess
GO:0045087innate immune response-IEAProcess
GO:0045785positive regulation of cell adhesion20810993.IMPProcess
GO:0048025negative regulation of mRNA splicing, via spliceosome21873635.IBAProcess
GO:0048025negative regulation of mRNA splicing, via spliceosome10022843.IDAProcess
GO:0048786presynaptic active zone-IEAComponent
GO:0050687negative regulation of defense response to virus19164550.IMPProcess
GO:0051897positive regulation of protein kinase B signaling16177118.IMPProcess
GO:0070131positive regulation of mitochondrial translation21873635.IBAProcess
GO:0070131positive regulation of mitochondrial translation-ISSProcess
GO:0090023positive regulation of neutrophil chemotaxis9461517.IDAProcess
GO:0097177mitochondrial ribosome binding21873635.IBAFunction
GO:0097177mitochondrial ribosome binding-ISSFunction
GO:0098978glutamatergic synapse-IEAComponent
GO:0098982GABA-ergic synapse-IEAComponent
GO:1900026positive regulation of substrate adhesion-dependent cell spreading11859136.IMPProcess
GO:1901165positive regulation of trophoblast cell migration20810993.IMPProcess
GO:2000510positive regulation of dendritic cell chemotaxis16140380.IMPProcess
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