EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18757437	Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma.	Cancer Res	2008 Sep 1	Fogal V	doi: 10.1158/0008-5472.CAN-07-6752.
22771308	Significance of hyaluronan binding protein (HABP1/P32/gC1qR) expression in advanced serous ovarian cancer patients.	Exp Mol Pathol	2013 Feb	Yu G	doi: 10.1016/j.yexmp.2012.06.007
25794640	Elevated expression of HABP1 is a novel prognostic indicator in triple-negative breast cancers.	Tumour Biol	2015 Jun	Wang J	doi: 10.1007/s13277-015-3131-x
21205079	Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy.	Cancer Sci	2011 Mar	Amamoto R	doi: 10.1111/j.1349-7006.2010.01828.x
21627988	Hyaluronan-binding protein 1 (HABP1/p32/gC1qR) induces melanoma cell migration and tumor growth by NF-kappa B dependent MMP-2 activation through integrin α(v)β(3) interaction.	Cell Signal	2011 Oct	Prakash M	doi: 10.1016/j.cellsig.2011.04.009
25061661	Increased hyaluronan levels in HABP1/p32/gC1qR overexpressing HepG2 cells inhibit autophagic vacuolation regulating tumor potency.	PLoS One	2014 Jul 25	Saha P	doi: 10.1371/journal.pone.0103208
21156793	The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies.	J Biol Chem	2011 Feb 18	S??nchez-Mart??n D	doi: 10.1074/jbc.M110.161927
21725590	The role of gC1qR in regulating survival of human papillomavirus 16 oncogene-transfected cervical cancer cells.	Int J Oncol	2011 Nov	Gao LJ	doi: 10.3892/ijo.2011.1108
19565630	Increased expression of hyaluronic acid binding protein 1 is correlated with poor prognosis in patients with breast cancer.	J Surg Oncol	2009 Oct 1	Chen YB	doi: 10.1002/jso.21329.
23924515	Interactome analysis reveals that C1QBP (complement component 1, q subcomponent binding protein) is associated with cancer cell chemotaxis and metastasis.	Mol Cell Proteomics	2013 Nov	Zhang X	doi: 10.1074/mcp.M113.029413
22101277	The mitochondrial protein C1qbp promotes cell proliferation, migration and resistance to cell death.	Cell Cycle	2011 Dec 1	McGee AM	doi: 10.4161/cc.10.23.18287
25355598	Overexpression of HABP1 correlated with clinicopathological characteristics and unfavorable prognosis in endometrial cancer.	Tumour Biol	2015 Feb	Zhao J	doi: 10.1007/s13277-014-2761-8
25573962	Complement component 1, q subcomponent binding protein is a marker for proliferation in breast cancer.	Exp Biol Med (Maywood)	2015 Jul	Scully OJ	doi: 10.1177/1535370214565075
20100866	Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation.	Mol Cell Biol	2010 Mar	Fogal V	doi: 10.1128/MCB.01101-09
25497084	C1QBP negatively regulates the activation of oncoprotein YBX1 in the renal cell carcinoma as revealed by interactomics analysis.	J Proteome Res	2015 Feb 6	Wang Y	doi: 10.1021/pr500847p
28039537	Hyaluronic acid binding protein 1 overexpression is an indicator for disease-free survival in cervical cancer.	Int J Clin Oncol	2017 Apr	Zhang M	doi: 10.1007/s10147-016-1077-7
28108744	Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women.	Oncotarget	2017 Feb 21	Jiang Y	doi: 10.18632/oncotarget.14737.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	5433358	Missense_Mutation	NA	Q212E	0.25
BLCA	chr17	5434884	Nonsense_Mutation	novel	E156*	0.44
BRCA	chr17	5433010	3'UTR	novel		0.68
CESC	chr17	5438845	Missense_Mutation	NA	D77N	0.29
CESC	chr17	5433401	Silent	rs184461242	D197D	0.09
CHOL	chr17	5438240	Missense_Mutation	novel	E89A	0.36
COAD	chr17	5433001	3'UTR	novel		0.44
COAD	chr17	5438154	Missense_Mutation	novel	A118T	0.38
COAD	chr17	5433132	Silent	novel	A244A	0.06
DLBC	chr17	5433032	Missense_Mutation	novel	F278V	0.25
GBM	chr17	5434900	Silent	rs535657744	S150S	0.41
GBM	chr17	5434889	Missense_Mutation	novel	K154T	0.07
GBM	chr17	5433055	Missense_Mutation	novel	T270N	0.05
HNSC	chr17	5433741	Silent	rs774258991	F168F	0.31
HNSC	chr17	5433127	Missense_Mutation	novel	R246Q	0.13
LUSC	chr17	5433764	Missense_Mutation	NA	E161K	0.41
MESO	chr17	5439064	Silent	novel	L4L	0.23
MESO	chr17	5438931	Missense_Mutation	novel	V48E	0.17
OV	chr17	5438131	Silent	NA	A125A	0.09
PAAD	chr17	5433328	Missense_Mutation	novel	T222A	0.19
SKCM	chr17	5434951	Silent	NA	F133F	0.3
SKCM	chr17	5434928	Missense_Mutation	NA	P141L	0.27
STAD	chr17	5433740	Missense_Mutation	rs371917632	V169M	0.19
STAD	chr17	5434935	Missense_Mutation	NA	I139V	0.1
TGCT	chr17	5433318	Missense_Mutation	novel	T225I	0.07
UCEC	chr17	5438210	Missense_Mutation	novel	H99R	0.4
UCEC	chr17	5438164	Silent	NA	N114N	0.42
UCEC	chr17	5432952	3'UTR	novel		0.43
UCEC	chr17	5438261	Missense_Mutation	NA	F82S	0.15
UCEC	chr17	5433050	Missense_Mutation	novel	L272I	0.21
UCEC	chr17	5438152	Silent	novel	A118A	0.36
UCEC	chr17	5433349	Missense_Mutation	rs115819590	G215S	0.41
UCEC	chr17	5433021	Silent	novel	S281S	0.29
UCEC	chr17	5433315	Missense_Mutation	novel	L226P	0.19
UCEC	chr17	5433756	Silent	novel	T163T	0.23
UCEC	chr17	5433383	Silent	NA	I203I	0.21
UCEC	chr17	5438202	Missense_Mutation	novel	L102I	0.42
UCEC	chr17	5433011	3'UTR	novel		0.37
UCS	chr17	5434875	Missense_Mutation	novel	E159K	0.08

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.2083	0.18166
LAML	DEL	0.0733	0.12511
LIHC	DEL	0.5568	3.9592e-10
THCA	DEL	0.016	0.221

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.029	Kaplan-Meier Survival Analysis
SARC	0.0042	Kaplan-Meier Survival Analysis
PRAD	0.03	Kaplan-Meier Survival Analysis
PAAD	0.032	Kaplan-Meier Survival Analysis
KICH	0.0058	Kaplan-Meier Survival Analysis
CHOL	0.0014	Kaplan-Meier Survival Analysis
LUAD	0.0047	Kaplan-Meier Survival Analysis
UVM	0.0037	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000108561 (Gene tree)
Gene ID: 708
Gene Symbol: C1QBP
Alias: HABP1|P32
Full Name: Complement C1q Binding Protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 16,054 bases
Position: chr17:5,432,777-5,448,830
Accession: 1243
RBP type: non-canonical RBP
Summary: The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10022843	The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation.	EMBO J	1999 Feb 15	Petersen-Mahrt SK	-
9678487	Physical association between the EBV protein EBNA-1 and P32/TAP/hyaluronectin.	J Biomed Sci	1998	Chen MR	-
10823864	Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria.	J Virol	2000 Jun	Beatch MD	-
16641292	Cellular splicing and transcription regulatory protein p32 represses adenovirus major late transcription and causes hyperphosphorylation of RNA polymerase II.	J Virol	2006 May	Ohrmalm C	-
22904065	p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability.	Nucleic Acids Res	2012 Oct	Yagi M	doi: 10.1093/nar/gks774
17698161	Analysis of the selective advantage conferred by a C-E1 fusion protein synthesized by rubella virus DI RNAs.	Virology	2007 Dec 5	Claus C	-
21920408	The role of TFAM-associated proteins in mitochondrial RNA metabolism.	Biochim Biophys Acta	2012 May	Uchiumi T	doi: 10.1016/j.bbagen.2011.08.014
23947187	[The functional and pathological analysis of mitochondrial protein p32].	Rinsho Byori	2013 Jun	Uchiumi T	-
26385742	Interactions between RNA-binding proteins and P32 homologues in trypanosomes and human cells.	Curr Genet	2016 Feb	Polledo JM	doi: 10.1007/s00294-015-0519-5
26816005	Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.	PLoS One	2016 Jan 27	Ansseau E	doi: 10.1371/journal.pone.0146893
27814609	Mitochondrial nucleic acid binding proteins associated with diseases.	Front Biosci (Landmark Ed)	2017 Jan 1	Uchiumi T	-
15163734	Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt.	J Virol	2004 Jun	Yao ZQ	-
25354864	[Expression of C1QBP gene and its correlation with drug resistance in human resistance choriocarcinoma cell line].	Zhonghua Fu Chan Ke Za Zhi	2014 Aug	Shen X	-
11812855	The trypanosome homolog of human p32 interacts with RBP16 and stimulates its gRNA binding activity.	Nucleic Acids Res	2001 Dec 15	Hayman ML	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000576122	C1QBP-207	383	-	ENSP00000458624	9 (aa)	-	A0A0G2JLC0
ENST00000573406	C1QBP-204	767	-	-	- (aa)	-	-
ENST00000574444	C1QBP-206	901	-	ENSP00000460308	178 (aa)	-	I3L3B0
ENST00000225698	C1QBP-201	1169	-	ENSP00000225698	282 (aa)	-	Q07021
ENST00000573421	C1QBP-205	330	-	-	- (aa)	-	-
ENST00000570805	C1QBP-202	688	-	ENSP00000460638	177 (aa)	-	I3L3Q7
ENST00000573204	C1QBP-203	911	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000108561's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108561's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	15243141.	IDA	Process
GO:0001849	complement component C1q binding	21873635.	IBA	Function
GO:0001849	complement component C1q binding	8195709.	IDA	Function
GO:0003714	transcription corepressor activity	21873635.	IBA	Function
GO:0003714	transcription corepressor activity	15243141.	IDA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	-	ISS	Function
GO:0005080	protein kinase C binding	-	IEA	Function
GO:0005515	protein binding	8710908.8900153.10831594.11086025.12034482.15031724.16721827.17486078.18191643.18676636.19164550.22118625.22238231.23986595.24955142.25497084.25852190.28018340.	IPI	Function
GO:0005540	hyaluronic acid binding	21873635.	IBA	Function
GO:0005540	hyaluronic acid binding	8567680.	IDA	Function
GO:0005615	extracellular space	-	IEA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	15243141.	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	11083468.19164550.	IDA	Component
GO:0005759	mitochondrial matrix	-	IEA	Component
GO:0005829	cytosol	15243141.	IDA	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0006955	immune response	8195709.	TAS	Process
GO:0006958	complement activation, classical pathway	-	IEA	Process
GO:0007597	blood coagulation, intrinsic pathway	-	TAS	Process
GO:0008134	transcription factor binding	21873635.	IBA	Function
GO:0008134	transcription factor binding	15243141.	IDA	Function
GO:0008380	RNA splicing	-	IEA	Process
GO:0008494	translation activator activity	21873635.	IBA	Function
GO:0009986	cell surface	21873635.	IBA	Component
GO:0009986	cell surface	17881511.	IDA	Component
GO:0014065	phosphatidylinositol 3-kinase signaling	16177118.	IMP	Process
GO:0016020	membrane	8662673.11290596.	IDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0030449	regulation of complement activation	21873635.	IBA	Process
GO:0030449	regulation of complement activation	8195709.	IDA	Process
GO:0030984	kininogen binding	21873635.	IBA	Function
GO:0030984	kininogen binding	8662673.	IDA	Function
GO:0031690	adrenergic receptor binding	-	ISS	Function
GO:0032689	negative regulation of interferon-gamma production	17881511.	IDA	Process
GO:0032695	negative regulation of interleukin-12 production	16177118.17881511.	IDA	Process
GO:0039534	negative regulation of MDA-5 signaling pathway	19164550.	IDA	Process
GO:0039536	negative regulation of RIG-I signaling pathway	19164550.	IDA	Process
GO:0042256	mature ribosome assembly	21873635.	IBA	Process
GO:0042256	mature ribosome assembly	21536856.	IMP	Process
GO:0043065	positive regulation of apoptotic process	15031724.	IMP	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0045785	positive regulation of cell adhesion	20810993.	IMP	Process
GO:0048025	negative regulation of mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0048025	negative regulation of mRNA splicing, via spliceosome	10022843.	IDA	Process
GO:0048786	presynaptic active zone	-	IEA	Component
GO:0050687	negative regulation of defense response to virus	19164550.	IMP	Process
GO:0051897	positive regulation of protein kinase B signaling	16177118.	IMP	Process
GO:0070131	positive regulation of mitochondrial translation	21873635.	IBA	Process
GO:0070131	positive regulation of mitochondrial translation	-	ISS	Process
GO:0090023	positive regulation of neutrophil chemotaxis	9461517.	IDA	Process
GO:0097177	mitochondrial ribosome binding	21873635.	IBA	Function
GO:0097177	mitochondrial ribosome binding	-	ISS	Function
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0098982	GABA-ergic synapse	-	IEA	Component
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	11859136.	IMP	Process
GO:1901165	positive regulation of trophoblast cell migration	20810993.	IMP	Process
GO:2000510	positive regulation of dendritic cell chemotaxis	16140380.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.