EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26542179	The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney.	Genes Chromosomes Cancer	2016 Feb	Gooskens SL	doi: 10.1002/gcc.22320
23483955	14-3-3?? overexpression contributes to epithelial-mesenchymal transition of hepatocellular carcinoma.	PLoS One	2013	Liu TA	doi: 10.1371/journal.pone.0057968
26945340	Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney.	Am J Surg Pathol	2016 Aug	Kao YC	doi: 10.1097/PAS.0000000000000629.
24536031	Proteomic identification of 14-3-3 as a linker protein between pERK1/2 inhibition and BIM upregulation in human osteosarcoma cells.	J Orthop Res	2014 Jun	Kim KO	doi: 10.1002/jor.22598
22899242	RKIP and 14-3-3?? exert an opposite effect on human gastric cancer cells SGC7901 by regulating the ERK/MAPK pathway differently.	Dig Dis Sci	2013 Feb	Yan L	doi: 10.1007/s10620-012-2341-y
27863420	YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells: new insights about YWHAE role in the tumor development and metastasis process.	Oncotarget	2016 Dec 20	Leal MF	doi: 10.18632/oncotarget.13381.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	1400176	5'UTR	novel		0.45
BLCA	chr17	1364975	Nonsense_Mutation	novel	K50*	0.05
BLCA	chr17	1364976	Nonsense_Mutation	novel	Y49*	0.05
BLCA	chr17	1361215	Missense_Mutation	novel	Y152C	0.48
BLCA	chr17	1354328	Missense_Mutation	NA	D200H	0.31
BRCA	chr17	1361172	Silent	rs146808095	T166T	0.4
CESC	chr17	1361172	Silent	rs146808095	T166T	0.46
CESC	chr17	1400209	5'UTR	novel		0.24
CESC	chr17	1361913	Missense_Mutation	NA	F120L	0.31
CESC	chr17	1361174	Missense_Mutation	novel	T166A	0.22
CHOL	chr17	1344766	3'UTR	novel		0.12
COAD	chr17	1400079	Missense_Mutation	rs777592060	A11V	0.42
COAD	chr17	1400183	5'UTR	novel		0.43
COAD	chr17	1361296	Missense_Mutation	novel	K125T	0.21
COAD	chr17	1364998	Missense_Mutation	NA	R42I	0.17
GBM	chr17	1400101	Nonsense_Mutation	NA	R4*	0.37
HNSC	chr17	1400092	Missense_Mutation	rs11552915	L7V	0.17
HNSC	chr17	1354264	In_Frame_Del	novel	I220del	0.09
HNSC	chr17	1361262	Silent	rs752894008	A136A	0.08
KIRC	chr17	1365030	Frame_Shift_Ins	novel	*G32Qfs11**	0.05
KIRC	chr17	1365032	Missense_Mutation	novel	A31T	0.02
KIRP	chr17	1361928	Silent	rs758745399	G115G	0.03
KIRP	chr17	1345439	3'UTR	novel		0.49
KIRP	chr17	1400131	5'UTR	rs767076639		0.47
KIRP	chr17	1345386	3'UTR	novel		0.58
LGG	chr17	1400139	5'UTR	novel		0.91
LIHC	chr17	1361130	Missense_Mutation	NA	F180L	0.72
LIHC	chr17	1345430	3'UTR	novel		0.07
LIHC	chr17	1361959	Missense_Mutation	novel	D105G	0.08
LUAD	chr17	1354343	Missense_Mutation	NA	A195T	0.19
LUSC	chr17	1400072	Silent	rs748149659	L13L	0.5
LUSC	chr17	1354344	Missense_Mutation	novel	L194F	0.27
LUSC	chr17	1361907	Silent	rs779406770	Y122Y	0.3
OV	chr17	1400163	5'UTR	novel		0.9
OV	chr17	1364993	Missense_Mutation	NA	L44F	0.61
OV	chr17	1400138	5'UTR	novel		0.32
PAAD	chr17	1400166	5'UTR	rs538610783		0.22
PAAD	chr17	1354337	Missense_Mutation	novel	A197T	0.04
PAAD	chr17	1361273	Missense_Mutation	novel	A133T	0.18
PAAD	chr17	1400079	Missense_Mutation	rs777592060	A11V	0.37
READ	chr17	1400134	5'UTR	novel		0.25
READ	chr17	1361199	Silent	NA	D157D	0.45
SKCM	chr17	1345437	3'UTR	novel		0.27
SKCM	chr17	1345438	3'UTR	novel		0.26
SKCM	chr17	1361928	Silent	rs758745399	G115G	0.39
SKCM	chr17	1361110	Missense_Mutation	NA	S187F	0.09
SKCM	chr17	1361137	Missense_Mutation	NA	S178F	0.12
SKCM	chr17	1345353	3'UTR	novel		0.42
STAD	chr17	1400235	5'UTR	novel		0.27
STAD	chr17	1361267	Missense_Mutation	NA	F135I	0.17
STAD	chr17	1354264	In_Frame_Del	novel	I220del	0.08
STAD	chr17	1361248	Missense_Mutation	NA	R141K	0.2
STAD	chr17	1361260	Missense_Mutation	novel	T137I	0.77
STAD	chr17	1345408	3'UTR	novel		0.46
STAD	chr17	1364865	Silent	NA	R86R	0.38
THCA	chr17	1361200	Missense_Mutation	NA	D157V	0.03
UCEC	chr17	1400166	5'UTR	rs538610783		0.39
UCEC	chr17	1400068	Missense_Mutation	novel	E15K	0.53
UCEC	chr17	1345478	Missense_Mutation	rs754262216	A246V	0.15
UCEC	chr17	1345091	3'UTR	novel		0.42
UCEC	chr17	1361926	Missense_Mutation	NA	E116V	0.47
UCEC	chr17	1361985	Silent	rs767528415	I96I	0.33
UCEC	chr17	1345344	3'UTR	novel		0.35
UCEC	chr17	1354228	Nonsense_Mutation	NA	S233*	0.4
UCEC	chr17	1344899	3'UTR	novel		0.67
UCEC	chr17	1344938	3'UTR	rs778922436		0.55
UCEC	chr17	1345168	3'UTR	rs112066507		0.33
UCEC	chr17	1361225	Silent	novel	L149L	0.43
UCEC	chr17	1344637	3'UTR	novel		0.37
UCEC	chr17	1345458	Missense_Mutation	novel	E253K	0.42
UCEC	chr17	1364951	Missense_Mutation	novel	A58T	0.12
UCEC	chr17	1344587	3'UTR	novel		0.32
UCEC	chr17	1365057	Splice_Region	novel	E22E	0.52
UCEC	chr17	1344608	3'UTR	novel		0.29
UCEC	chr17	1344745	3'UTR	novel		0.33
UCEC	chr17	1345498	Splice_Region	novel	G239G	0.46
UCEC	chr17	1400162	5'UTR	novel		0.41
UCEC	chr17	1344575	3'UTR	rs144973335		0.19
UCEC	chr17	1344727	3'UTR	novel		0.29
UCEC	chr17	1361172	Silent	rs146808095	T166T	0.05
UCEC	chr17	1345369	3'UTR	novel		0.12
UCEC	chr17	1345445	3'UTR	NA		0.28
UCEC	chr17	1400178	5'UTR	NA		0.29
UCEC	chr17	1345464	Nonsense_Mutation	novel	E251*	0.23

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.2083	0.18166
LAML	DEL	0.0733	0.12511
LIHC	DEL	0.527	3.9592e-10
LUAD	DEL	0.4496	0.00029194
SKCM	DEL	0.3025	0.21028
THCA	DEL	0.016	0.221

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0011	Kaplan-Meier Survival Analysis
SARC	0.0014	Kaplan-Meier Survival Analysis
ACC	0.0047	Kaplan-Meier Survival Analysis
HNSC	0.03	Kaplan-Meier Survival Analysis
LAML	0.019	Kaplan-Meier Survival Analysis
KICH	0.01	Kaplan-Meier Survival Analysis
UCEC	0.0001	Kaplan-Meier Survival Analysis
LIHC	0.044	Kaplan-Meier Survival Analysis
LGG	0.0002	Kaplan-Meier Survival Analysis
CHOL	0.024	Kaplan-Meier Survival Analysis
LUAD	0.019	Kaplan-Meier Survival Analysis
UVM	0.018	Kaplan-Meier Survival Analysis
OV	0.046	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000108953 (Gene tree)
Gene ID: 7531
Gene Symbol: YWHAE
Alias: FLJ45465
Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 56,107 bases
Position: chr17:1,344,272-1,400,378
Accession: 12851
RBP type: non-canonical RBP
Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30718516	Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control.	Nat Commun	2019 Feb 4	Winz ML	doi: 10.1038/s41467-019-08382-z.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498643	YWHAE-207	312	-	-	- (aa)	-	-
ENST00000496706	YWHAE-206	732	-	ENSP00000466324	115 (aa)	-	K7EM20
ENST00000469398	YWHAE-203	676	-	-	- (aa)	-	-
ENST00000575977	YWHAE-212	540	-	ENSP00000460712	107 (aa)	-	I3L3T1
ENST00000576854	YWHAE-213	1374	-	-	- (aa)	-	-
ENST00000466227	YWHAE-202	1377	-	ENSP00000464883	109 (aa)	-	K7EIT4
ENST00000571732	YWHAE-208	1818	XM_017025005	ENSP00000461762	233 (aa)	XP_016880494	P62258
ENST00000573026	YWHAE-210	780	-	ENSP00000458386	38 (aa)	-	I3L0W5
ENST00000489287	YWHAE-205	465	-	-	- (aa)	-	-
ENST00000572108	YWHAE-209	258	-	-	- (aa)	-	-
ENST00000486241	YWHAE-204	691	-	-	- (aa)	-	-
ENST00000264335	YWHAE-201	2211	XM_005256784	ENSP00000264335	255 (aa)	XP_005256841	P62258
ENST00000573196	YWHAE-211	739	-	ENSP00000461766	94 (aa)	-	B4DJF2

Gene Model

Click here to download ENSG00000108953's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa04722	Neurotrophin signaling pathway	KEGG
hsa05160	Hepatitis C	KEGG
hsa05203	Viral carcinogenesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000108953	Platelet Count	7.552e-005	-
ENSG00000108953	Breast Density	6.9046861E-006	-
ENSG00000108953	Breast Density	1.3327706E-005	-
ENSG00000108953	Schizophrenia	3E-6	26198764

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000108953	rs9908552	17	1394697	T	Schizophrenia	26198764	[NR]	1.05	EFO_0000692
ENSG00000108953	rs56007784	17	1387656	C	Schizophrenia	28991256	[1.04-1.08]	1.059	EFO_0000692
ENSG00000108953	rs75543711	17	1352780	?	Reaction time	29844566	[0.0061-0.0128] unit decrease	0.009456	EFO_0008393
ENSG00000108953	rs56007784	17	1387656	C	Schizophrenia	30285260	[1.03-1.07]	1.052	EFO_0000692

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000108953's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000108953	YWHAE	99	71.930	ENSG00000170027	YWHAG	100	63.968	Homo_sapiens
ENSG00000108953	YWHAE	100	69.565	ENSG00000128245	YWHAH	99	63.265	Homo_sapiens
ENSG00000108953	YWHAE	100	100.000	ENSMUSG00000020849	Ywhae	100	100.000	Mus_musculus
ENSG00000108953	YWHAE	99	71.930	ENSMUSG00000051391	Ywhag	100	63.968	Mus_musculus
ENSG00000108953	YWHAE	100	69.565	ENSMUSG00000018965	Ywhah	99	63.265	Mus_musculus
ENSG00000108953	YWHAE	96	83.636	YDR099W	BMH2	93	73.913	Saccharomyces_cerevisiae
ENSG00000108953	YWHAE	96	84.545	YER177W	BMH1	92	75.203	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000165	MAPK cascade	12917326.	IDA	Process
GO:0001764	neuron migration	-	IEA	Process
GO:0003064	regulation of heart rate by hormone	11953308.	NAS	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005246	calcium channel regulator activity	18029012.	IDA	Function
GO:0005515	protein binding	1266503.7644510.10644344.11504882.11697890.12392720.12917326.14743216.15722337.16099986.16227609.16260042.16376338.16407301.16511560.16775625.17085597.18045992.18227151.18356162.18458160.18573912.19172738.19640509.20618440.20642453.20936779.21044950.21242966.21282530.21346153.21988832.22151054.22246185.23075850.23572552.23622247.23752268.24255178.24366813.24725412.24947832.25588844.25751139.25852190.26496610.27173435.29128334.29769719.30611118.	IPI	Function
GO:0005634	nucleus	12917326.	IDA	Component
GO:0005737	cytoplasm	12917326.	IDA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005871	kinesin complex	-	IEA	Component
GO:0005886	plasma membrane	18029012.	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006605	protein targeting	-	IEA	Process
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0015459	potassium channel regulator activity	11953308.	IDA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0019899	enzyme binding	10788521.	IPI	Function
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0021762	substantia nigra development	22926577.	HEP	Process
GO:0021766	hippocampus development	-	IEA	Process
GO:0021987	cerebral cortex development	-	IEA	Process
GO:0023026	MHC class II protein complex binding	20458337.	HDA	Function
GO:0031625	ubiquitin protein ligase binding	19725078.	IPI	Function
GO:0034504	protein localization to nucleus	29769719.	IMP	Process
GO:0034605	cellular response to heat	12917326.	IDA	Process
GO:0035329	hippo signaling	-	TAS	Process
GO:0035556	intracellular signal transduction	7644510.	TAS	Process
GO:0042470	melanosome	-	IEA	Component
GO:0042802	identical protein binding	17085597.20936779.	IPI	Function
GO:0042826	histone deacetylase binding	10869435.	IPI	Function
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	TAS	Process
GO:0044325	ion channel binding	11953308.18029012.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046827	positive regulation of protein export from nucleus	12917326.	IDA	Process
GO:0046982	protein heterodimerization activity	11953308.	IPI	Function
GO:0050815	phosphoserine residue binding	10869435.	IPI	Function
GO:0051219	phosphoprotein binding	10869435.	IPI	Function
GO:0051480	regulation of cytosolic calcium ion concentration	18029012.	IDA	Process
GO:0060306	regulation of membrane repolarization	11953308.	IDA	Process
GO:0061024	membrane organization	-	TAS	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0086013	membrane repolarization during cardiac muscle cell action potential	11953308.	IC	Process
GO:0086091	regulation of heart rate by cardiac conduction	11953308.	IC	Process
GO:0090724	central region of growth cone	-	IEA	Component
GO:0097110	scaffold protein binding	10409742.	IPI	Function
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	-	IEA	Process
GO:1900034	regulation of cellular response to heat	-	TAS	Process
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	-	TAS	Process
GO:1901016	regulation of potassium ion transmembrane transporter activity	11953308.	IDA	Process
GO:1901020	negative regulation of calcium ion transmembrane transporter activity	18029012.	IDA	Process
GO:1902309	negative regulation of peptidyl-serine dephosphorylation	11953308.	IDA	Process
GO:1905913	negative regulation of calcium ion export across plasma membrane	18029012.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.