EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	28575242	Missense_Mutation	rs753185090	R69C	0.31
BLCA	chr17	28574753	Silent	novel	A161A	0.61
BLCA	chr17	28574560	Missense_Mutation	novel	I186M	0.4
BLCA	chr17	28575275	Silent	rs780045497	L58L	0.29
BRCA	chr17	28573347	3'UTR	novel		0.67
BRCA	chr17	28574240	Missense_Mutation	NA	V209A	0.31
BRCA	chr17	28574147	Missense_Mutation	novel	C240Y	0.33
BRCA	chr17	28575468	Missense_Mutation	NA	R22Q	0.15
CESC	chr17	28573742	Missense_Mutation	rs762828594	R331Q	0.39
CESC	chr17	28574529	Missense_Mutation	rs749373286	H197Y	0.45
CESC	chr17	28575526	Missense_Mutation	NA	H3D	0.23
COAD	chr17	28575435	Missense_Mutation	rs775893117	A33V	0.24
COAD	chr17	28574719	Missense_Mutation	rs747367976	R173C	0.29
ESCA	chr17	28575456	Missense_Mutation	rs752045255	P26L	0.24
ESCA	chr17	28574092	Silent	novel	R258R	0.3
GBM	chr17	28573853	Missense_Mutation	novel	R294Q	0.41
GBM	chr17	28574090	Missense_Mutation	rs765845189	R259H	0.18
GBM	chr17	28575224	Missense_Mutation	novel	G75R	0.23
GBM	chr17	28574131	Silent	novel	T245T	0.4
HNSC	chr17	28573466	3'UTR	novel		0.17
HNSC	chr17	28575223	Missense_Mutation	novel	G75A	0.25
HNSC	chr17	28575176	Missense_Mutation	novel	G91S	0.27
HNSC	chr17	28574233	Silent	novel	A211A	0.09
HNSC	chr17	28575168	Silent	NA	P93P	0.3
KIRP	chr17	28573837	Frame_Shift_Del	novel	*W296Sfs35**	0.16
KIRP	chr17	28574093	Missense_Mutation	rs145665688	R258H	0.56
LGG	chr17	28575536	5'UTR	novel		0.24
LIHC	chr17	28573906	Silent	rs369962449	S276S	0.33
LUAD	chr17	28575456	Missense_Mutation	NA	P26Q	0.08
LUAD	chr17	28575175	Missense_Mutation	novel	G91V	0.25
LUSC	chr17	28575275	Silent	rs780045497	L58L	0.35
OV	chr17	28573497	3'UTR	novel		0.47
OV	chr17	28573824	Missense_Mutation	rs376690171	R304C	0.19
PRAD	chr17	28575423	Missense_Mutation	novel	V37A	0.15
PRAD	chr17	28574501	Missense_Mutation	NA	T206K	0.04
PRAD	chr17	28574190	Missense_Mutation	novel	G226R	0.37
READ	chr17	28574093	Missense_Mutation	rs145665688	R258H	0.25
READ	chr17	28574090	Missense_Mutation	rs765845189	R259H	0.42
SKCM	chr17	28574527	Silent	rs564709825	H197H	0.35
SKCM	chr17	28573854	Nonsense_Mutation	NA	R294*	0.15
SKCM	chr17	28575168	Silent	NA	P93P	0.52
SKCM	chr17	28573856	Missense_Mutation	NA	P293L	0.08
SKCM	chr17	28573827	Missense_Mutation	NA	G303R	0.8
STAD	chr17	28575218	Missense_Mutation	rs201657122	V77I	0.2
STAD	chr17	28574081	Missense_Mutation	NA	P262H	0.44
STAD	chr17	28575494	Silent	NA	K13K	0.33
STAD	chr17	28573906	Silent	rs369962449	S276S	0.11
STAD	chr17	28574526	Missense_Mutation	novel	D198N	0.27
STAD	chr17	28574966	Missense_Mutation	NA	E122G	0.14
STAD	chr17	28573820	Missense_Mutation	NA	A305V	0.32
STAD	chr17	28575468	Missense_Mutation	NA	R22Q	0.23
STAD	chr17	28573933	Splice_Region	NA	G267G	0.18
STAD	chr17	28573815	Missense_Mutation	NA	Q307K	0.2
STAD	chr17	28573844	Missense_Mutation	rs150324059	A297V	0.26
UCEC	chr17	28574090	Missense_Mutation	rs765845189	R259H	0.38
UCEC	chr17	28573462	3'UTR	novel		0.42
UCEC	chr17	28574795	Silent	rs758753501	K147K	0.45
UCEC	chr17	28573803	Missense_Mutation	rs758865156	L311F	0.13
UCEC	chr17	28574516	Missense_Mutation	rs182794210	R201H	0.56
UCEC	chr17	28575469	Missense_Mutation	rs140001292	R22W	0.58
UCEC	chr17	28573823	Missense_Mutation	NA	R304H	0.41
UCEC	chr17	28574735	Silent	rs200821079	N167N	0.19
UCEC	chr17	28573487	3'UTR	novel		0.33
UCEC	chr17	28573534	Missense_Mutation	novel	A363T	0.13
UCEC	chr17	28574839	Missense_Mutation	novel	E133K	0.44
UCEC	chr17	28573547	Silent	NA	Y358Y	0.31
UCEC	chr17	28573844	Missense_Mutation	rs150324059	A297V	0.2
UCEC	chr17	28574133	Missense_Mutation	novel	T245A	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0	0.18166
THCA	DEL	0.002	0.221
THYM	AMP	0.065	0.24554
UCEC	AMP	0.1095	1.8255e-06
UCS	DEL	0.2857	0.19877

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.023	Kaplan-Meier Survival Analysis
HNSC	0.0069	Kaplan-Meier Survival Analysis
LUSC	0.037	Kaplan-Meier Survival Analysis
KIRP	0.00044	Kaplan-Meier Survival Analysis
COAD	0.0096	Kaplan-Meier Survival Analysis
CESC	0.0036	Kaplan-Meier Survival Analysis
LAML	0.00064	Kaplan-Meier Survival Analysis
UVM	0.04	Kaplan-Meier Survival Analysis
OV	0.00053	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000109107 (Gene tree)
Gene ID: 230
Gene Symbol: ALDOC
Alias: N
Full Name: aldolase, fructose-bisphosphate C
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 4,150 bases
Position: chr17:28,573,115-28,577,264
Accession: 418
RBP type: non-canonical RBP
Summary: This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000395319	ALDOC-202	1519	-	ENSP00000378729	336 (aa)	-	A8MVZ9
ENST00000395321	ALDOC-203	1722	XM_005257949	ENSP00000378731	364 (aa)	XP_005258006	P09972
ENST00000578590	ALDOC-206	839	-	ENSP00000463118	122 (aa)	-	J3QKK1
ENST00000460201	ALDOC-205	922	-	ENSP00000463174	180 (aa)	-	J3QKP5
ENST00000581807	ALDOC-207	580	-	ENSP00000465623	135 (aa)	-	K7EKH5
ENST00000226253	ALDOC-201	1982	-	ENSP00000226253	364 (aa)	-	P09972
ENST00000584086	ALDOC-209	686	-	ENSP00000462674	175 (aa)	-	J3KSV6
ENST00000435638	ALDOC-204	579	-	ENSP00000398976	149 (aa)	-	C9J8F3
ENST00000582381	ALDOC-208	571	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000109107's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa00030	Pentose phosphate pathway	KEGG
hsa00051	Fructose and mannose metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000109107's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000109107	ALDOC	100	67.407	WBGene00011474	aldo-1	98	65.084	Caenorhabditis_elegans
ENSG00000109107	ALDOC	98	61.732	WBGene00017166	aldo-2	97	62.396	Caenorhabditis_elegans
ENSG00000109107	ALDOC	100	83.333	ENSG00000149925	ALDOA	100	85.784	Homo_sapiens
ENSG00000109107	ALDOC	100	83.889	ENSMUSG00000030695	Aldoa	100	87.712	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004332	fructose-bisphosphate aldolase activity	9244396.15537755.	IDA	Function
GO:0005515	protein binding	11399750.25416956.25910212.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	9244396.	IC	Component
GO:0006000	fructose metabolic process	3105602.	TAS	Process
GO:0006094	gluconeogenesis	-	TAS	Process
GO:0008092	cytoskeletal protein binding	9244396.	IDA	Function
GO:0030388	fructose 1,6-bisphosphate metabolic process	9244396.15537755.	IDA	Process
GO:0030855	epithelial cell differentiation	21492153.	IEP	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0061621	canonical glycolysis	-	TAS	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:1904724	tertiary granule lumen	-	TAS	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.