EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30089216	Silencing non-SMC chromosome-associated polypeptide G inhibits proliferation and induces apoptosis in hepatocellular carcinoma cells.	Can J Physiol Pharmacol	2018 Dec	Liu K	doi: 10.1139/cjpp-2018-0195

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr4	17812975	In_Frame_Del	novel	L126_I143del	0.16
BLCA	chr4	17814952	Missense_Mutation	NA	G215V	0.43
BLCA	chr4	17813115	Missense_Mutation	novel	P172T	0.17
BLCA	chr4	17843278	Intron	rs774042015		0.35
BLCA	chr4	17845835	3'Flank	novel		0.27
BLCA	chr4	17845898	3'Flank	novel		0.34
BRCA	chr4	17815330	Silent	NA	L249L	0.22
BRCA	chr4	17845729	3'Flank	rs769565617		0.07
BRCA	chr4	17811031	5'UTR	novel		0.33
BRCA	chr4	17817441	Missense_Mutation	NA	N319I	0.11
BRCA	chr4	17839781	Nonsense_Mutation	NA	E858*	0.26
BRCA	chr4	17842341	Silent	rs761385706	T962T	0.2
BRCA	chr4	17843433	3'UTR	rs775104185		0.14
BRCA	chr4	17837295	Missense_Mutation	novel	R749P	0.08
CESC	chr4	17837775	Nonsense_Mutation	NA	Q814*	0.31
CESC	chr4	17844388	3'UTR	novel		0.43
CESC	chr4	17843439	3'UTR	novel		0.4
CESC	chr4	17844482	3'UTR	novel		0.11
COAD	chr4	17840646	Missense_Mutation	NA	V936A	0.38
COAD	chr4	17825049	Nonsense_Mutation	novel	E489*	0.17
COAD	chr4	17839741	Silent	rs773411854	S844S	0.1
COAD	chr4	17845733	3'Flank	rs527647162		0.12
COAD	chr4	17813070	Missense_Mutation	novel	N157H	0.27
COAD	chr4	17840140	Nonsense_Mutation	NA	E900*	0.24
COAD	chr4	17837752	Missense_Mutation	novel	T806K	0.3
COAD	chr4	17834391	Frame_Shift_Ins	NA	*I662Nfs7**	0.37
COAD	chr4	17814898	Missense_Mutation	novel	R197Q	0.34
COAD	chr4	17834318	Missense_Mutation	rs146806366	V635A	0.29
COAD	chr4	17839685	Missense_Mutation	novel	V826L	0.31
COAD	chr4	17823749	Missense_Mutation	novel	D454E	0.23
COAD	chr4	17843341	Missense_Mutation	NA	M988I	0.45
COAD	chr4	17818090	Splice_Site	NA	X373_splice	0.27
COAD	chr4	17812951	Missense_Mutation	novel	R117T	0.37
COAD	chr4	17825005	Missense_Mutation	novel	V474D	0.11
COAD	chr4	17817450	Missense_Mutation	NA	G322D	0.28
COAD	chr4	17842365	Missense_Mutation	novel	E970D	0.1
COAD	chr4	17845657	3'Flank	novel		0.28
COAD	chr4	17824996	Missense_Mutation	rs770259903	A471V	0.13
COAD	chr4	17824997	Silent	novel	A471A	0.19
COAD	chr4	17825025	Missense_Mutation	rs765333490	D481N	0.43
COAD	chr4	17828380	Missense_Mutation	NA	E586K	0.17
COAD	chr4	17814969	Missense_Mutation	novel	K221E	0.4
COAD	chr4	17837158	Splice_Site	novel	X704_splice	0.2
COAD	chr4	17817428	Frame_Shift_Ins	novel	*G315Efs4**	0.05
COAD	chr4	17817429	Frame_Shift_Ins	novel	*L316Nfs11**	0.05
COAD	chr4	17842356	Missense_Mutation	NA	Q967H	0.18
DLBC	chr4	17842339	Missense_Mutation	novel	T962P	0.4
ESCA	chr4	17837693	Silent	novel	A786A	0.53
ESCA	chr4	17837695	Missense_Mutation	novel	S787F	0.53
ESCA	chr4	17812220	Splice_Site	novel	X38_splice	0.12
GBM	chr4	17812938	Missense_Mutation	novel	A113S	0.31
GBM	chr4	17813063	Silent	novel	K154K	0.56
GBM	chr4	17845830	3'Flank	rs779850195		0.26
GBM	chr4	17818061	Missense_Mutation	NA	P364L	0.16
HNSC	chr4	17845784	3'Flank	novel		0.3
HNSC	chr4	17839689	Frame_Shift_Ins	novel	D828*	0.24
HNSC	chr4	17828298	Missense_Mutation	novel	Q558H	0.36
HNSC	chr4	17825544	Missense_Mutation	rs748530489	E546K	0.11
KIRC	chr4	17817993	Silent	NA	A341A	0.3
KIRC	chr4	17817402	Frame_Shift_Ins	novel	*I307Kfs2**	0.36
LAML	chr4	17815330	Silent	NA	L249L	0.4
LGG	chr4	17842358	Missense_Mutation	NA	T968I	0.39
LIHC	chr4	17839757	Missense_Mutation	NA	Y850H	0.29
LIHC	chr4	17828345	Nonsense_Mutation	novel	S574*	0.46
LUAD	chr4	17818021	Missense_Mutation	NA	D351Y	0.29
LUAD	chr4	17815292	Missense_Mutation	NA	H237Y	0.1
LUAD	chr4	17812958	Missense_Mutation	novel	C119W	0.19
LUAD	chr4	17814866	Missense_Mutation	novel	L186F	0.07
LUAD	chr4	17840146	Missense_Mutation	novel	G902R	0.31
LUAD	chr4	17823123	Missense_Mutation	novel	R420K	0.14
LUAD	chr4	17815316	Missense_Mutation	novel	Q245E	0.2
LUAD	chr4	17814932	Missense_Mutation	novel	K208N	0.2
LUSC	chr4	17818078	Missense_Mutation	novel	Y370H	0.28
LUSC	chr4	17825049	Missense_Mutation	NA	E489K	0.25
LUSC	chr4	17839808	Missense_Mutation	NA	L867F	0.17
LUSC	chr4	17825434	Missense_Mutation	NA	C509F	0.15
LUSC	chr4	17817976	Missense_Mutation	novel	A336S	0.4
LUSC	chr4	17823124	Splice_Site	NA	X420_splice	0.22
LUSC	chr4	17814968	Silent	novel	V220V	0.28
LUSC	chr4	17837276	Missense_Mutation	novel	E743Q	0.1
OV	chr4	17837234	Missense_Mutation	novel	I729V	0.04
OV	chr4	17812418	Silent	novel	L103L	0.1
PAAD	chr4	17843355	Missense_Mutation	rs757772284	R993Q	0.19
PAAD	chr4	17837646	Missense_Mutation	novel	E771Q	0.15
PRAD	chr4	17837226	Missense_Mutation	novel	S726I	0.11
READ	chr4	17828301	Missense_Mutation	NA	K559N	0.37
READ	chr4	17845733	3'Flank	rs527647162		0.19
SARC	chr4	17810923	5'UTR	novel		0.38
SKCM	chr4	17811094	Missense_Mutation	NA	R6K	0.71
SKCM	chr4	17837763	Missense_Mutation	novel	G810R	0.47
SKCM	chr4	17837764	Missense_Mutation	novel	G810E	0.47
SKCM	chr4	17843278	Intron	rs774042015		0.3
SKCM	chr4	17828340	Silent	NA	S572S	0.32
SKCM	chr4	17824998	Missense_Mutation	NA	P472S	0.68
SKCM	chr4	17828320	Missense_Mutation	novel	E566K	0.54
SKCM	chr4	17845648	3'Flank	novel		0.55
SKCM	chr4	17813067	Missense_Mutation	NA	P156S	0.2
SKCM	chr4	17837689	Missense_Mutation	NA	P785R	0.4
STAD	chr4	17813136	Missense_Mutation	NA	V179L	0.17
STAD	chr4	17817947	Missense_Mutation	NA	I326S	0.35
STAD	chr4	17837295	Missense_Mutation	NA	R749Q	0.27
STAD	chr4	17843382	Missense_Mutation	rs771576325	S1002N	0.06
STAD	chr4	17837285	Missense_Mutation	NA	V746I	0.36
STAD	chr4	17825385	Missense_Mutation	NA	A493T	0.15
STAD	chr4	17834343	Missense_Mutation	NA	K643N	0.23
STAD	chr4	17845767	3'Flank	rs372845898		0.27
STAD	chr4	17831013	Missense_Mutation	novel	I594R	0.15
STAD	chr4	17837309	Missense_Mutation	rs111401034	V754M	0.23
STAD	chr4	17843375	Frame_Shift_Ins	novel	*S1002Kfs2**	0.36
STAD	chr4	17814954	Missense_Mutation	novel	R216G	0.24
STAD	chr4	17845810	3'Flank	NA		0.13
UCEC	chr4	17843555	3'UTR	rs573559380		0.42
UCEC	chr4	17825409	Missense_Mutation	NA	E501K	0.27
UCEC	chr4	17844388	3'UTR	novel		0.56
UCEC	chr4	17818033	Nonsense_Mutation	NA	E355*	0.34
UCEC	chr4	17825409	Missense_Mutation	NA	E501K	0.37
UCEC	chr4	17813026	Missense_Mutation	novel	K142R	0.46
UCEC	chr4	17837283	Missense_Mutation	novel	D745G	0.4
UCEC	chr4	17824984	Nonsense_Mutation	NA	S467*	0.15
UCEC	chr4	17817298	Silent	novel	Q271Q	0.04
UCEC	chr4	17842368	Silent	rs753639012	A971A	0.19
UCEC	chr4	17823760	Missense_Mutation	novel	R458K	0.29
UCEC	chr4	17839695	Missense_Mutation	novel	N829S	0.35
UCEC	chr4	17831046	Missense_Mutation	NA	V605A	0.42
UCEC	chr4	17843343	Missense_Mutation	novel	R989K	0.39
UCEC	chr4	17834511	Missense_Mutation	novel	F699L	0.09
UCEC	chr4	17837735	Silent	novel	E800E	0.25
UCEC	chr4	17828380	Missense_Mutation	NA	E586K	0.35
UCEC	chr4	17812941	Missense_Mutation	NA	V114L	0.22
UCEC	chr4	17828365	Missense_Mutation	novel	M581V	0.06
UCEC	chr4	17812273	Missense_Mutation	NA	V55A	0.31
UCEC	chr4	17845901	3'Flank	NA		0.25
UCEC	chr4	17811073	5'UTR	novel		0.2
UCEC	chr4	17818033	Nonsense_Mutation	NA	E355*	0.19
UCEC	chr4	17844584	3'UTR	novel		0.46
UCEC	chr4	17834449	Nonsense_Mutation	NA	E679*	0.45
UCEC	chr4	17834437	Missense_Mutation	novel	D675Y	0.45
UCEC	chr4	17825049	Nonsense_Mutation	novel	E489*	0.2
UCEC	chr4	17825522	Silent	novel	E538E	0.35
UCEC	chr4	17844512	3'UTR	novel		0.33
UCEC	chr4	17845319	3'Flank	novel		0.33
UCEC	chr4	17837631	Missense_Mutation	rs746347285	N766Y	0.29
UCEC	chr4	17837676	Silent	rs765215058	L781L	0.29
UCEC	chr4	17845138	3'Flank	novel		0.63
UCEC	chr4	17815326	Missense_Mutation	novel	M248T	0.29
UCEC	chr4	17831006	Missense_Mutation	novel	G592R	0.39
UCEC	chr4	17831102	Missense_Mutation	rs569951009	V624I	0.3
UCEC	chr4	17839811	Silent	novel	L868L	0.3
UCEC	chr4	17844388	3'UTR	novel		0.22
UCEC	chr4	17825409	Nonsense_Mutation	novel	E501*	0.38
UCEC	chr4	17845695	3'Flank	novel		0.47
UCEC	chr4	17840091	Silent	novel	C883C	0.38
UCEC	chr4	17845095	3'Flank	novel		0.39
UCEC	chr4	17818033	Nonsense_Mutation	NA	E355*	0.28
UCEC	chr4	17818077	Silent	NA	D369D	0.14
UCEC	chr4	17844477	3'UTR	novel		0.42
UCEC	chr4	17828306	Missense_Mutation	novel	L561P	0.26
UCEC	chr4	17845856	3'Flank	novel		0.29
UCEC	chr4	17814914	Silent	NA	C202C	0.34
UCEC	chr4	17828380	Missense_Mutation	NA	E586K	0.18
UCEC	chr4	17831016	Missense_Mutation	novel	S595I	0.15
UCEC	chr4	17840618	Nonsense_Mutation	novel	E927*	0.22
UCEC	chr4	17845773	3'Flank	novel		0.29
UCEC	chr4	17814872	Missense_Mutation	NA	E188D	0.32
UCEC	chr4	17817941	Missense_Mutation	rs768114793	K324T	0.33
UCEC	chr4	17844388	3'UTR	novel		0.25
UCEC	chr4	17812317	Nonsense_Mutation	novel	E70*	0.28
UCEC	chr4	17825486	Silent	novel	K526K	0.32
UCEC	chr4	17844329	3'UTR	novel		0.35
UCEC	chr4	17840674	Silent	novel	T945T	0.54
UCEC	chr4	17823059	Nonsense_Mutation	NA	E399*	0.28
UCEC	chr4	17845155	3'Flank	novel		0.25
UCEC	chr4	17845773	3'Flank	novel		0.18
UCEC	chr4	17812370	Silent	novel	D87D	0.24
UCEC	chr4	17828294	Missense_Mutation	rs773335393	L557S	0.37
UCEC	chr4	17834500	Missense_Mutation	novel	L696I	0.2
UCEC	chr4	17823760	Missense_Mutation	NA	R458I	0.28
UCEC	chr4	17845645	3'Flank	novel		0.41
UCEC	chr4	17843532	3'UTR	novel		0.35
UCEC	chr4	17839770	Missense_Mutation	novel	L854S	0.28
UCEC	chr4	17843555	3'UTR	rs573559380		0.3
UCEC	chr4	17845899	3'Flank	novel		0.5
UCEC	chr4	17843227	Intron	novel		0.27
UCEC	chr4	17845478	3'Flank	novel		0.46
UCEC	chr4	17825556	Missense_Mutation	novel	E550K	0.32
UCEC	chr4	17844768	3'UTR	novel		0.47
UCEC	chr4	17837328	Missense_Mutation	novel	A760V	0.2
UCEC	chr4	17844597	3'UTR	novel		0.34
UCS	chr4	17823059	Nonsense_Mutation	NA	E399*	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
HNSC	DEL	0.3276	0.00046209
LIHC	DEL	0.1892	0.14149

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0079	Kaplan-Meier Survival Analysis
KIRC	0.00011	Kaplan-Meier Survival Analysis
SARC	0.013	Kaplan-Meier Survival Analysis
ACC	0.00015	Kaplan-Meier Survival Analysis
UCS	0.025	Kaplan-Meier Survival Analysis
PRAD	0.035	Kaplan-Meier Survival Analysis
KIRP	0.00012	Kaplan-Meier Survival Analysis
COAD	0.017	Kaplan-Meier Survival Analysis
PAAD	0.00013	Kaplan-Meier Survival Analysis
PCPG	0.029	Kaplan-Meier Survival Analysis
KICH	0.007	Kaplan-Meier Survival Analysis
UCEC	0.0035	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.00011	Kaplan-Meier Survival Analysis
UVM	0.0072	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000109805 (Gene tree)
Gene ID: 64151
Gene Symbol: NCAPG
Alias: FLJ12450|hCAP-G|CAP-G|YCG1
Full Name: non-SMC condensin I complex subunit G
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 34,053 bases
Position: chr4:17,810,813-17,844,865
Accession: 24304
RBP type: non-canonical RBP
Summary: This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000251496	NCAPG-201	4661	XM_011513876	ENSP00000251496	1015 (aa)	XP_011512178	Q9BPX3
ENST00000510063	NCAPG-203	807	-	ENSP00000425625	269 (aa)	-	H0Y9Z8
ENST00000509719	NCAPG-202	537	-	-	- (aa)	-	-
ENST00000513226	NCAPG-204	795	-	-	- (aa)	-	-
ENST00000514176	NCAPG-205	3017	-	ENSP00000423042	232 (aa)	-	D6RA93

Gene Model

Click here to download ENSG00000109805's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000109805	Body Height	2E-40	25429064

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000109805	rs16895802	4	17814266	C	Height	25429064	[0.087-0.119] unit increase	0.103	EFO_0004339
ENSG00000109805	rs11932971	4	17822279	T	Intelligence	29942086	z-score increase	7.213	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000109805's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000779	condensed chromosome, centromeric region	-	IEA	Component
GO:0000793	condensed chromosome	21873635.	IBA	Component
GO:0000796	condensin complex	11136719.	IDA	Component
GO:0005515	protein binding	12138188.17268547.26496610.	IPI	Function
GO:0005634	nucleus	10910072.	NAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007076	mitotic chromosome condensation	21873635.	IBA	Process
GO:0007076	mitotic chromosome condensation	11136719.	IDA	Process
GO:0007076	mitotic chromosome condensation	10910072.	NAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0051301	cell division	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.