EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19676054	Udp-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer.	Int J Cancer	2010 Jan 15	Huang D	doi: 10.1002/ijc.24820.
29479058	Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration.	Oncogene	2018 May	Oyinlade O	doi: 10.1038/s41388-018-0138-y

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr4	39510389	Silent	NA	L209L	0.08
BLCA	chr4	39505732	Missense_Mutation	novel	D308A	0.22
BLCA	chr4	39505733	Missense_Mutation	novel	D308Y	0.22
BLCA	chr4	39505266	Missense_Mutation	NA	S381F	0.14
BLCA	chr4	39510713	Missense_Mutation	novel	E138G	0.15
BLCA	chr4	39500092	3'UTR	novel		0.55
BLCA	chr4	39505289	Silent	novel	R373R	0.21
BRCA	chr4	39503913	Missense_Mutation	NA	D446N	0.12
CESC	chr4	39505717	Missense_Mutation	novel	R313M	0.17
COAD	chr4	39503954	Frame_Shift_Ins	novel	*M432Nfs20**	0.29
COAD	chr4	39514134	Missense_Mutation	NA	F71L	0.33
COAD	chr4	39500028	3'UTR	novel		0.53
COAD	chr4	39500038	3'UTR	novel		0.21
COAD	chr4	39505298	Frame_Shift_Del	NA	*V371Yfs6**	0.34
COAD	chr4	39510708	Missense_Mutation	novel	I140L	0.16
COAD	chr4	39514133	Frame_Shift_Del	rs765734647	*S72Lfs18**	0.4
COAD	chr4	39510729	Missense_Mutation	NA	P133S	0.44
COAD	chr4	39514142	Missense_Mutation	rs140219602	L69I	0.11
COAD	chr4	39499982	3'UTR	novel		0.32
ESCA	chr4	39500136	3'UTR	novel		0.11
ESCA	chr4	39510821	Missense_Mutation	novel	R102L	0.09
GBM	chr4	39510783	Missense_Mutation	rs140504706	R115C	0.08
GBM	chr4	39514084	Missense_Mutation	novel	S88Y	0.2
GBM	chr4	39510760	Silent	novel	G122G	0.06
GBM	chr4	39503959	Silent	novel	K430K	0.05
HNSC	chr4	39505719	Missense_Mutation	novel	R312S	0.28
HNSC	chr4	39500217	Missense_Mutation	novel	I471L	0.07
HNSC	chr4	39505658	Missense_Mutation	novel	I333F	0.19
HNSC	chr4	39510833	Missense_Mutation	novel	M98T	0.22
HNSC	chr4	39521472	Missense_Mutation	rs369608407	Y14C	0.25
KIRP	chr4	39514133	Missense_Mutation	rs769243823	S72P	0.42
LGG	chr4	39508648	Missense_Mutation	novel	S275N	0.41
LUAD	chr4	39514121	Missense_Mutation	NA	D76N	0.19
LUAD	chr4	39514181	Nonsense_Mutation	NA	G56*	0.15
LUAD	chr4	39505330	Missense_Mutation	NA	E360K	0.14
LUAD	chr4	39510689	Missense_Mutation	NA	A146V	0.27
LUAD	chr4	39510460	Missense_Mutation	NA	P186A	0.12
LUSC	chr4	39500212	Silent	novel	P472P	0.06
LUSC	chr4	39509794	Missense_Mutation	NA	Q259H	0.45
LUSC	chr4	39505308	Missense_Mutation	novel	Y367C	0.26
OV	chr4	39503906	Missense_Mutation	novel	L448R	0.21
OV	chr4	39500178	Missense_Mutation	NA	L484F	0.47
OV	chr4	39509840	Missense_Mutation	novel	T244R	0.09
PAAD	chr4	39510765	Missense_Mutation	rs766669367	N121D	0.31
PAAD	chr4	39521401	Missense_Mutation	novel	N38D	0.2
PRAD	chr4	39509892	Missense_Mutation	novel	L227V	0.08
PRAD	chr4	39504442	Missense_Mutation	NA	I413T	0.1
READ	chr4	39521398	Nonsense_Mutation	NA	E39*	0.19
SARC	chr4	39503952	Frame_Shift_Del	novel	H429*	0.17
SARC	chr4	39514158	Silent	novel	S63S	0.34
SARC	chr4	39514159	Missense_Mutation	novel	S63F	0.34
SKCM	chr4	39505618	Missense_Mutation	NA	R346K	0.15
SKCM	chr4	39508611	Silent	NA	L287L	0.59
SKCM	chr4	39521459	Silent	NA	P18P	0.43
STAD	chr4	39503955	Frame_Shift_Del	rs774133578	*M432Cfs2**	0.15
STAD	chr4	39503954	Frame_Shift_Ins	novel	*M432Nfs20**	0.22
STAD	chr4	39510842	Missense_Mutation	NA	T95N	0.22
STAD	chr4	39505652	Missense_Mutation	novel	G335R	0.25
STAD	chr4	39521388	Missense_Mutation	novel	I42N	0.16
STAD	chr4	39503885	Missense_Mutation	rs755764491	I455T	0.21
STAD	chr4	39510783	Missense_Mutation	rs140504706	R115C	0.31
UCEC	chr4	39521502	Missense_Mutation	novel	I4N	0.29
UCEC	chr4	39500232	Missense_Mutation	rs750080424	V466M	0.47
UCEC	chr4	39508630	Missense_Mutation	novel	V281G	0.38
UCEC	chr4	39514181	Nonsense_Mutation	NA	G56*	0.35
UCEC	chr4	39521413	Missense_Mutation	novel	V34I	0.09
UCEC	chr4	39509884	Missense_Mutation	novel	Q229H	0.06
UCEC	chr4	39510384	Missense_Mutation	rs770721281	T211N	0.07
UCEC	chr4	39510666	Missense_Mutation	novel	L154V	0.11
UCEC	chr4	39505302	Missense_Mutation	novel	P369L	0.3
UCEC	chr4	39503921	Missense_Mutation	NA	R443H	0.29
UCEC	chr4	39510723	Missense_Mutation	rs768674438	R135W	0.47
UCEC	chr4	39514103	Missense_Mutation	novel	A82T	0.32
UCEC	chr4	39514172	Missense_Mutation	novel	E59K	0.33
UCEC	chr4	39504435	Silent	NA	T415T	0.31
UCEC	chr4	39514106	Nonsense_Mutation	novel	E81*	0.41
UCEC	chr4	39521373	Missense_Mutation	novel	S47Y	0.57
UCEC	chr4	39504430	Missense_Mutation	novel	W417L	0.39
UCEC	chr4	39521495	Missense_Mutation	novel	K6N	0.41
UCEC	chr4	39514132	Missense_Mutation	novel	S72Y	0.34
UCEC	chr4	39500128	3'UTR	novel		0.13
UCEC	chr4	39514133	Frame_Shift_Del	rs765734647	*S72Lfs18**	0.41
UCEC	chr4	39510705	Missense_Mutation	rs115137663	R141C	0.53
UCEC	chr4	39503955	Frame_Shift_Del	rs774133578	*M432Cfs2**	0.48
UCEC	chr4	39521398	Nonsense_Mutation	NA	E39*	0.38
UCEC	chr4	39521468	Silent	novel	V15V	0.14
UCEC	chr4	39500219	Missense_Mutation	novel	R470I	0.33
UCEC	chr4	39521474	Silent	NA	G13G	0.29
UCEC	chr4	39504429	Missense_Mutation	novel	W417C	0.34
UCEC	chr4	39510701	Missense_Mutation	rs368044471	R142H	0.34
UCS	chr4	39505302	Missense_Mutation	novel	P369R	0.25

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	AMP	0.1297	0.0362
READ	DEL	0.3333	0.14076

Survival Analysis

Cancer	P-value	Q-value
ACC	0.0033	Kaplan-Meier Survival Analysis
SKCM	0.028	Kaplan-Meier Survival Analysis
BRCA	0.01	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.0067	Kaplan-Meier Survival Analysis
LAML	0.0031	Kaplan-Meier Survival Analysis
LIHC	0.0063	Kaplan-Meier Survival Analysis
LUAD	0.015	Kaplan-Meier Survival Analysis
UVM	0.028	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000109814 (Gene tree)
Gene ID: 7358
Gene Symbol: UGDH
Alias: N
Full Name: UDP-glucose 6-dehydrogenase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 29,557 bases
Position: chr4:39,498,755-39,528,311
Accession: 12525
RBP type: non-canonical RBP
Summary: The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23137539	Rossmann-fold motifs can confer multiple functions to metabolic enzymes: RNA binding and ribonuclease activity of a UDP-glucose dehydrogenase.	Biochem Biophys Res Commun	2013 Jan 4	Barbas A	doi: 10.1016/j.bbrc.2012.10.091

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000514106	UGDH-210	568	-	ENSP00000425834	153 (aa)	-	E7ETF4
ENST00000316423	UGDH-201	3216	XM_005262667	ENSP00000319501	494 (aa)	XP_005262724	O60701
ENST00000501493	UGDH-202	2826	-	ENSP00000422909	427 (aa)	-	O60701
ENST00000510881	UGDH-209	549	-	ENSP00000424059	55 (aa)	-	E9PBD2
ENST00000515398	UGDH-212	584	-	-	- (aa)	-	-
ENST00000503779	UGDH-203	575	-	ENSP00000424435	55 (aa)	-	E9PBD2
ENST00000507089	UGDH-206	1712	-	ENSP00000426560	397 (aa)	-	O60701
ENST00000515021	UGDH-211	861	-	ENSP00000421954	181 (aa)	-	E7EV97
ENST00000505698	UGDH-204	433	-	ENSP00000422565	84 (aa)	-	E7ER95
ENST00000510490	UGDH-208	534	-	ENSP00000427708	53 (aa)	-	D6RHF4
ENST00000509391	UGDH-207	577	-	ENSP00000422603	130 (aa)	-	E7ER83
ENST00000506179	UGDH-205	3021	-	ENSP00000421757	494 (aa)	-	O60701

Gene Model

Click here to download ENSG00000109814's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00040	Pentose and glucuronate interconversions	KEGG
hsa00053	Ascorbate and aldarate metabolism	KEGG
hsa00520	Amino sugar and nucleotide sugar metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000109814	Platelet Function Tests	2.9673700E-005	-
ENSG00000109814	Platelet Function Tests	2.9673700E-005	-
ENSG00000109814	Platelet Function Tests	2.8331100E-005	-
ENSG00000109814	Platelet Function Tests	2.1238000E-005	-
ENSG00000109814	Platelet Function Tests	3.5690800E-005	-
ENSG00000109814	Platelet Function Tests	3.5690800E-005	-
ENSG00000109814	Platelet Function Tests	3.3300400E-005	-
ENSG00000109814	Platelet Function Tests	2.8975700E-005	-
ENSG00000109814	Autistic Disorder	9.0510000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000109814	rs56118664	4	39516245	G	Ankle injury	28957384		1.8994	EFO_1002021
ENSG00000109814	rs3755899	4	39528080	G	Peripheral arterial disease (traffic-related air pollution interaction)	27082954	[1772.72-1806.94]	1789.83	EFO_0004265\|EFO_0007908

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000109814's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000109814	UGDH	98	64.062	WBGene00005022	sqv-4	95	65.659	Caenorhabditis_elegans

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001702	gastrulation with mouth forming second	-	ISS	Process
GO:0003979	UDP-glucose 6-dehydrogenase activity	27966912.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005975	carbohydrate metabolic process	-	IEA	Process
GO:0006024	glycosaminoglycan biosynthetic process	21873635.	IBA	Process
GO:0006065	UDP-glucuronate biosynthetic process	27966912.	IDA	Process
GO:0006065	UDP-glucuronate biosynthetic process	-	IEA	Process
GO:0006065	UDP-glucuronate biosynthetic process	-	TAS	Process
GO:0015012	heparan sulfate proteoglycan biosynthetic process	-	ISS	Process
GO:0030206	chondroitin sulfate biosynthetic process	-	ISS	Process
GO:0034214	protein hexamerization	27966912.	IDA	Process
GO:0051287	NAD binding	-	IEA	Function
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0070062	extracellular exosome	23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.