EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28607951	PGC-1 Coactivators: Shepherding the Mitochondrial Biogenesis of Tumors.	Trends Cancer	2016 Oct	Luo C	doi: 10.1016/j.trecan.2016.09.006.
21914785	PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.	Cancer Res	2011 Nov 1	Bhalla K	doi: 10.1158/0008-5472.CAN-11-1011
17290397	EP1-4 subtype, COX and PPAR gamma receptor expression in colorectal cancer in prediction of disease-specific mortality.	Int J Cancer	2007 Jul 15	Gustafsson A	-
26119730	Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma.	Cell Rep	2015 Jul 7	LaGory EL	doi: 10.1016/j.celrep.2015.06.006
24403067	Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin.	J Biol Chem	2014 Feb 21	Neill T	doi: 10.1074/jbc.M113.512566
27878239	AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway.	Int J Oncol	2017 Jan	Morishita M	doi: 10.3892/ijo.2016.3775
28381162	Peroxisome proliferator-activated receptor gamma coactivator-1 alpha acts as a tumor suppressor in hepatocellular carcinoma.	Tumour Biol	2017 Apr	Liu R	doi: 10.1177/1010428317695031.
15254719	The localisation and reduction of nuclear staining of PPARgamma and PGC-1 in human breast cancer.	Oncol Rep	2004 Aug	Watkins G	-
25585584	Overexpression of PGC1α enhances cell proliferation and tumorigenesis of HEK293 cells through the upregulation of Sp1 and Acyl-CoA binding protein.	Int J Oncol	2015 Mar	Shin SW	doi: 10.3892/ijo.2015.2834
21862870	Bax is necessary for PGC1α pro-apoptotic effect in colorectal cancer cells.	Cell Cycle	2011 Sep 1	D'Errico I	-
27916422	PGC-1 alpha interacts with microRNA-217 to functionally regulate breast cancer cell proliferation.	Biomed Pharmacother	2017 Jan	Zhang S	doi: 10.1016/j.biopha.2016.11.062.
21447778	Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.	Cancer Epidemiol Biomarkers Prev	2011 Jun	Permuth-Wey J	doi: 10.1158/1055-9965.EPI-10-1224
12866036	Expression of peroxisome-proliferator activated receptor-gamma (PPARgamma) and the PPARgamma co-activator, PGC-1, in human breast cancer correlates with clinical outcomes.	Int J Cancer	2003 Sep 20	Jiang WG	-
24583643	RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis.	Cell Death Differ	2014 Jul	Chen W	doi: 10.1038/cdd.2014.25
25241037	PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promotemetastasis.	Nat Cell Biol	2014 Oct	LeBleu VS	doi: 10.1038/ncb3039
16704985	Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer.	Carcinogenesis	2006 Nov	Wirtenberger M	-
19861117	The PGC-1alpha-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer.	Biochem Biophys Res Commun	2009 Dec 25	Cormio A	doi: 10.1016/j.bbrc.2009.10.114
19884383	Peroxisome proliferator-activated receptor gamma coactivator-1alpha interacts with the androgen receptor (AR) and promotes prostate cancer cell growth by activating the AR.	Mol Endocrinol	2010 Jan	Shiota M	doi: 10.1210/me.2009-0302
25779952	SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer.	Clin Cancer Res	2015 Jun 15	Vellinga TT	doi: 10.1158/1078-0432.CCR-14-2290
22285815	The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer.	Semin Cell Dev Biol	2012 Jun	Girnun GD	doi: 10.1016/j.semcdb.2012.01.007
17372612	PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway.	Cell Res	2007 Apr	Zhang Y	-
27102200	Alcohol-related breast cancer in postmenopausal women - effect of CYP19A1, PPARG and PPARGC1A polymorphisms on female sex-hormone levels and interaction with alcohol consumption and NSAID usage in a nested case-control study and a randomised controlled trial.	BMC Cancer	2016 Apr 21	Kopp TI	doi: 10.1186/s12885-016-2317-y.
24186207	Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.	Oncogene	2014 Nov 6	Tennakoon JB	doi: 10.1038/onc.2013.463
28051997	Genetic variation in PPARGC1A may affect the role of diet-associated inflammation in colorectal carcinogenesis.	Oncotarget	2017 Jan 31	Cho YA	doi: 10.18632/oncotarget.14347.
28453464	PPARGC1A and ADIPOQ polymorphisms are associated with aggressive prostate cancer in Mexican-Mestizo men with overweight or obesity.	Cancer Biomark	2017 Jul 4	Canto P	doi: 10.3233/CBM-160467.
28988825	PGC-1α Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs.	Cell Metab	2017 Nov 7	Andrzejewski S	doi: 10.1016/j.cmet.2017.09.006
29130104	Expression of fatty acid synthase is regulated by PGC1α and contributes to increased cell proliferation.	Oncol Rep	2017 Dec	Yun SH	doi: 10.3892/or.2017.6044
29566941	Peroxisome proliferator-activated receptor γ coactivator-1α is a predictor of lymph node metastasis and poor prognosis in human colorectal cancer.	Ann Diagn Pathol	2018 Apr	Yun SH	doi: 10.1016/j.anndiagpath.2017.11.007
29749474	PGC1α promotes cisplatin resistance in human ovarian carcinoma cells through upregulation of mitochondrial biogenesis.	Int J Oncol	2018 Jul	Shen L	doi: 10.3892/ijo.2018.4401
29888964	Promoter methylation of PGC1A and PGC1B predicts cancer incidence in a veteran cohort.	Epigenomics	2018 Jun	Kresovich JK	doi: 10.2217/epi-2017-0141

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr4	23814276	Missense_Mutation	rs781331386	E403Q	0.43
ACC	chr4	23802335	Missense_Mutation	rs539338812	R677H	0.44
BLCA	chr4	23884816	Nonsense_Mutation	novel	W57*	0.21
BLCA	chr4	23814496	Missense_Mutation	novel	K329N	0.54
BLCA	chr4	23812828	Missense_Mutation	novel	K646N	0.09
BLCA	chr4	23828502	Missense_Mutation	novel	D219Y	0.31
BLCA	chr4	23814391	Silent	novel	L364L	0.18
BLCA	chr4	23813691	Splice_Region	NA	R598R	0.35
BLCA	chr4	23814147	Missense_Mutation	NA	P446S	0.19
BLCA	chr4	23814545	Missense_Mutation	novel	S313F	0.18
BLCA	chr4	23889944	Missense_Mutation	novel	M5K	0.25
BLCA	chr4	23814486	Missense_Mutation	novel	Y333H	0.14
BLCA	chr4	23801729	Splice_Site	novel	X765_splice	0.3
BLCA	chr4	23802313	Missense_Mutation	novel	I684M	0.14	RRM_1
BLCA	chr4	23813028	Missense_Mutation	rs773200805	R631W	0.25
BLCA	chr4	23812796	Missense_Mutation	NA	R657Q	0.41
BLCA	chr4	23814260	Missense_Mutation	NA	R408T	0.35
BRCA	chr4	23813102	Missense_Mutation	NA	S606N	0.35
BRCA	chr4	23828476	In_Frame_Ins	novel	E227_N228insALGFIFVPLLFCLIL	0.09
BRCA	chr4	23795522	3'UTR	novel		0.19
BRCA	chr4	23814379	Silent	rs201394320	H368H	0.14
BRCA	chr4	23884784	Missense_Mutation	novel	Q68K	0.08
BRCA	chr4	23812788	Missense_Mutation	NA	E660Q	0.28
BRCA	chr4	23828462	Missense_Mutation	novel	S232I	0.2
BRCA	chr4	23814420	Missense_Mutation	rs749421285	Y355N	0.4
BRCA	chr4	23795916	Nonsense_Mutation	NA	S768*	0.24
BRCA	chr4	23813078	Missense_Mutation	rs139240743	R614Q	0.29
BRCA	chr4	23813763	Nonsense_Mutation	NA	R574*	0.15
BRCA	chr4	23795795	3'UTR	novel		0.21
BRCA	chr4	23813083	Silent	rs369563669	T612T	0.05
CESC	chr4	23884821	Silent	novel	L55L	0.14
CESC	chr4	23793393	3'UTR	novel		0.33
CESC	chr4	23828493	Missense_Mutation	NA	H222Y	0.61
CESC	chr4	23794069	3'UTR	novel		0.38
CESC	chr4	23814398	Nonsense_Mutation	NA	S362*	0.39
CESC	chr4	23795076	3'UTR	novel		0.19
CESC	chr4	23794277	3'UTR	novel		0.21
CHOL	chr4	23793904	3'UTR	novel		0.36
COAD	chr4	23828493	Missense_Mutation	NA	H222N	0.33
COAD	chr4	23831618	Missense_Mutation	NA	A123V	0.12
COAD	chr4	23795865	Missense_Mutation	novel	F785S	0.24
COAD	chr4	23828506	Silent	rs753811432	N217N	0.35
COAD	chr4	23829534	Missense_Mutation	NA	C161R	0.32
COAD	chr4	23814526	Silent	novel	S319S	0.21
COAD	chr4	23802234	Missense_Mutation	rs753923087	R711W	0.19	RRM_1
COAD	chr4	23831654	Missense_Mutation	rs779660669	A111V	0.42
COAD	chr4	23831599	Silent	novel	P129P	0.41
COAD	chr4	23814114	Nonsense_Mutation	novel	E457*	0.36
COAD	chr4	23831563	Silent	rs369519960	P141P	0.14
COAD	chr4	23813031	Missense_Mutation	novel	R630C	0.61
COAD	chr4	23814360	Missense_Mutation	rs199772441	R375W	0.12
COAD	chr4	23812796	Missense_Mutation	NA	R657Q	0.12
COAD	chr4	23828608	Splice_Region	NA		0.22
COAD	chr4	23814456	Missense_Mutation	novel	N343D	0.33
COAD	chr4	23795830	Missense_Mutation	rs34129331	R797C	0.28
COAD	chr4	23831637	Missense_Mutation	NA	V117M	0.44
COAD	chr4	23814369	Nonsense_Mutation	novel	K372*	0.14
COAD	chr4	23814370	Missense_Mutation	novel	R371S	0.14
COAD	chr4	23814209	Missense_Mutation	NA	S425Y	0.17
COAD	chr4	23795656	3'UTR	novel		0.43
COAD	chr4	23814033	Missense_Mutation	novel	L484V	0.45
COAD	chr4	23801826	Missense_Mutation	novel	E733K	0.39	RRM_1
COAD	chr4	23884688	Intron	rs542246794		0.17
COAD	chr4	23795905	Missense_Mutation	NA	D772Y	0.24
COAD	chr4	23814360	Missense_Mutation	rs199772441	R375W	0.26
COAD	chr4	23824312	Missense_Mutation	rs139281425	R282H	0.09
ESCA	chr4	23829556	Missense_Mutation	novel	N153K	0.08
ESCA	chr4	23795826	Missense_Mutation	novel	R798K	0.25
ESCA	chr4	23829528	Missense_Mutation	novel	G163S	0.84
ESCA	chr4	23794203	3'UTR	novel		0.26
GBM	chr4	23802278	Missense_Mutation	novel	R696H	0.05	RRM_1
GBM	chr4	23812759	Missense_Mutation	novel	R669S	0.28
GBM	chr4	23813834	Missense_Mutation	novel	S550Y	0.26
GBM	chr4	23814524	Missense_Mutation	novel	C320Y	0.1
GBM	chr4	23812815	Missense_Mutation	rs143103266	R651C	0.43
GBM	chr4	23813044	Missense_Mutation	novel	R625S	0.09
HNSC	chr4	23884784	Nonsense_Mutation	novel	Q68*	0.06
HNSC	chr4	23824360	Splice_Region	novel		0.14
HNSC	chr4	23814524	Missense_Mutation	novel	C320F	0.38
HNSC	chr4	23889947	Missense_Mutation	novel	D4V	0.34
HNSC	chr4	23802335	Missense_Mutation	rs539338812	R677H	0.23
HNSC	chr4	23813941	Silent	rs529792659	S514S	0.2
HNSC	chr4	23813940	Missense_Mutation	rs374643892	E515K	0.36
KIRC	chr4	23814499	Silent	NA	S328S	0.22
KIRC	chr4	23831609	Missense_Mutation	NA	S126Y	0.13
KIRP	chr4	23831716	Silent	novel	A90A	0.41
KIRP	chr4	23884845	Silent	novel	D47D	0.22
KIRP	chr4	23828526	Missense_Mutation	NA	L211I	0.37
LGG	chr4	23814007	Silent	NA	E492E	0.2
LGG	chr4	23828567	Missense_Mutation	NA	C197Y	0.3
LGG	chr4	23801797	Silent	rs181250217	N742N	0.14
LGG	chr4	23813050	Silent	novel	R623R	0.35
LGG	chr4	23813728	Silent	novel	R585R	0.36
LGG	chr4	23814582	Frame_Shift_Ins	novel	*P301Ffs17**	0.08
LGG	chr4	23814584	In_Frame_Ins	novel	T299_P300insL	0.08
LIHC	chr4	23884614	Intron	novel		0.5
LIHC	chr4	23813702	Missense_Mutation	NA	R594I	0.19
LIHC	chr4	23824500	Missense_Mutation	novel	T256A	0.17
LIHC	chr4	23802225	Nonsense_Mutation	novel	G714*	0.25	RRM_1
LIHC	chr4	23795889	Missense_Mutation	NA	K777M	0.05
LUAD	chr4	23828543	Missense_Mutation	novel	R205L	0.3
LUAD	chr4	23814103	Silent	rs777545886	A460A	0.23
LUAD	chr4	23814104	Missense_Mutation	novel	A460D	0.22
LUAD	chr4	23814158	Frame_Shift_Del	novel	*K442Sfs21**	0.29
LUAD	chr4	23812834	Missense_Mutation	NA	R644S	0.15
LUAD	chr4	23884705	Intron	novel		0.06
LUAD	chr4	23814425	Missense_Mutation	NA	E353V	0.13
LUAD	chr4	23814159	Nonsense_Mutation	NA	K442*	0.15
LUAD	chr4	23795848	Nonsense_Mutation	novel	E791*	0.13
LUAD	chr4	23828420	Nonsense_Mutation	novel	S246*	0.48
LUAD	chr4	23802316	Missense_Mutation	novel	K683N	0.36	RRM_1
LUAD	chr4	23813806	Silent	novel	S559S	0.39
LUAD	chr4	23814210	Missense_Mutation	novel	S425T	0.22
LUAD	chr4	23831674	Missense_Mutation	NA	D104E	0.18
LUAD	chr4	23801856	Missense_Mutation	novel	R723S	0.33	RRM_1
LUAD	chr4	23828524	Silent	NA	L211L	0.16
LUAD	chr4	23824477	Silent	novel	T263T	0.22
LUAD	chr4	23814605	Missense_Mutation	novel	G293V	0.44
LUAD	chr4	23795746	3'UTR	novel		0.14
LUAD	chr4	23802234	Silent	NA	R711R	0.15
LUAD	chr4	23831672	Missense_Mutation	novel	G105V	0.19
LUAD	chr4	23814436	Silent	NA	P349P	0.2
LUAD	chr4	23831665	Silent	rs768048177	P107P	0.15
LUAD	chr4	23812822	Missense_Mutation	NA	E648D	0.08
LUAD	chr4	23828589	Missense_Mutation	NA	S190G	0.33
LUAD	chr4	23802254	Missense_Mutation	NA	E704V	0.7	RRM_1
LUAD	chr4	23801784	Frame_Shift_Ins	novel	E747*	0.37
LUAD	chr4	23884812	Silent	novel	C58C	0.08
LUAD	chr4	23813752	Silent	rs146697747	S577S	0.17
LUAD	chr4	23801733	Missense_Mutation	novel	L764V	0.4
LUAD	chr4	23801809	Silent	novel	L738L	0.12
LUAD	chr4	23814569	Missense_Mutation	novel	N305I	0.17
LUAD	chr4	23801856	Frame_Shift_Del	novel	*R723Vfs42**	0.07	RRM_1
LUSC	chr4	23813765	Missense_Mutation	NA	S573F	0.27
LUSC	chr4	23802284	Missense_Mutation	NA	R694M	0.27	RRM_1
LUSC	chr4	23812772	Missense_Mutation	novel	R665M	0.2
LUSC	chr4	23813030	Missense_Mutation	rs372413128	R630H	0.11
LUSC	chr4	23829465	Missense_Mutation	novel	K184E	0.78
LUSC	chr4	23802255	Missense_Mutation	NA	E704Q	0.1	RRM_1
LUSC	chr4	23814384	Nonsense_Mutation	NA	G367*	0.8
LUSC	chr4	23884870	Missense_Mutation	NA	S39C	0.56
LUSC	chr4	23812839	Nonsense_Mutation	novel	E643*	0.32
LUSC	chr4	23828589	Missense_Mutation	novel	S190C	0.21
LUSC	chr4	23814432	Nonsense_Mutation	novel	Q351*	0.44
LUSC	chr4	23824356	Splice_Region	novel		0.4
LUSC	chr4	23828461	Missense_Mutation	NA	S232R	0.33
LUSC	chr4	23802247	Silent	NA	C706C	0.6
OV	chr4	23802321	Missense_Mutation	rs776120045	G682S	0.44	RRM_1
OV	chr4	23814441	Missense_Mutation	rs146256421	G348R	0.65
OV	chr4	23812843	Silent	novel	Q641Q	0.04
OV	chr4	23795829	Missense_Mutation	rs200187877	R797H	0.39
OV	chr4	23814406	Silent	NA	S359S	0.26
OV	chr4	23828544	Missense_Mutation	novel	R205C	0.42
OV	chr4	23814243	Frame_Shift_Del	novel	*D414Mfs21**	0.05
PAAD	chr4	23813753	Missense_Mutation	rs17847360	S577L	0.23
PAAD	chr4	23813895	Missense_Mutation	novel	S530T	0.17
PAAD	chr4	23831563	Silent	rs369519960	P141P	0.19
PRAD	chr4	23814359	Missense_Mutation	novel	R375Q	0.16
PRAD	chr4	23814440	Missense_Mutation	NA	G348E	0.37
PRAD	chr4	23814025	Silent	NA	D486D	0.24
PRAD	chr4	23802338	Missense_Mutation	rs143962880	R676H	0.38
PRAD	chr4	23828506	Silent	rs753811432	N217N	0.16
SARC	chr4	23795248	3'UTR	novel		0.11
SARC	chr4	23795250	3'UTR	novel		0.11
SARC	chr4	23831735	Missense_Mutation	novel	N84I	0.33
SARC	chr4	23801848	Silent	novel	T725T	0.5
SKCM	chr4	23812809	Missense_Mutation	novel	E653K	0.42
SKCM	chr4	23814085	Silent	rs754478980	F466F	0.22
SKCM	chr4	23814518	Missense_Mutation	novel	T322I	0.24
SKCM	chr4	23824485	Missense_Mutation	NA	P261S	0.23
SKCM	chr4	23828505	Missense_Mutation	rs368992605	D218N	0.38
SKCM	chr4	23795814	3'UTR	novel		0.17
SKCM	chr4	23828437	Silent	NA	K240K	0.49
SKCM	chr4	23795903	Silent	novel	D772D	0.32
SKCM	chr4	23824490	Missense_Mutation	novel	S259F	0.36
SKCM	chr4	23795787	3'UTR	rs772347788		0.32
SKCM	chr4	23802282	Missense_Mutation	NA	D695N	0.1	RRM_1
SKCM	chr4	23813729	Missense_Mutation	NA	R585K	0.18
SKCM	chr4	23824357	Splice_Region	novel		0.12
SKCM	chr4	23828505	Missense_Mutation	rs368992605	D218N	0.22
SKCM	chr4	23814300	Missense_Mutation	NA	E395K	0.72
SKCM	chr4	23828505	Missense_Mutation	rs368992605	D218N	0.26
SKCM	chr4	23884885	Missense_Mutation	NA	P34L	0.1
SKCM	chr4	23801850	Missense_Mutation	NA	T725S	0.33	RRM_1
SKCM	chr4	23829562	Silent	novel	P151P	0.42
SKCM	chr4	23813967	Missense_Mutation	NA	A506T	0.54
SKCM	chr4	23814307	Silent	NA	S392S	0.3
SKCM	chr4	23801866	Silent	NA	F719F	0.74
SKCM	chr4	23831642	Missense_Mutation	NA	G115E	0.5
SKCM	chr4	23814107	Missense_Mutation	NA	R459Q	0.37
SKCM	chr4	23813695	Silent	NA	S596S	0.53
SKCM	chr4	23814114	Missense_Mutation	NA	E457K	0.4
SKCM	chr4	23814308	Missense_Mutation	novel	S392F	0.09
SKCM	chr4	23812824	Missense_Mutation	NA	E648K	0.34
SKCM	chr4	23795731	3'UTR	novel		0.39
SKCM	chr4	23795731	3'UTR	novel		0.16
SKCM	chr4	23831609	Missense_Mutation	novel	S126F	0.34
SKCM	chr4	23814195	Missense_Mutation	NA	D430N	0.12
SKCM	chr4	23824348	Missense_Mutation	NA	P270L	0.11
SKCM	chr4	23814109	Silent	novel	I458I	0.32
SKCM	chr4	23814016	Silent	novel	F489F	0.2
SKCM	chr4	23831697	Missense_Mutation	NA	D97N	0.11
SKCM	chr4	23812854	Missense_Mutation	rs772726563	E638K	0.14
SKCM	chr4	23824485	Missense_Mutation	NA	P261S	0.11
SKCM	chr4	23814427	Silent	NA	S352S	0.1
SKCM	chr4	23824357	Splice_Region	novel		0.23
SKCM	chr4	23795845	Missense_Mutation	novel	A792T	0.34
SKCM	chr4	23890072	5'UTR	novel		0.53
SKCM	chr4	23814385	Silent	NA	G366G	0.46
SKCM	chr4	23813837	Missense_Mutation	novel	D549V	0.33
SKCM	chr4	23813838	Missense_Mutation	novel	D549N	0.33
SKCM	chr4	23828578	Silent	rs574203083	A193A	0.56
SKCM	chr4	23813732	Missense_Mutation	novel	S584F	0.27
SKCM	chr4	23814276	Missense_Mutation	novel	E403K	0.35
SKCM	chr4	23824331	Missense_Mutation	novel	E276K	0.21
SKCM	chr4	23814585	Missense_Mutation	novel	P300S	0.14
SKCM	chr4	23824488	Missense_Mutation	NA	L260F	0.13
SKCM	chr4	23813792	Missense_Mutation	NA	R564K	0.24
SKCM	chr4	23814575	Missense_Mutation	NA	K303R	0.15
SKCM	chr4	23814370	Silent	novel	R371R	0.56
SKCM	chr4	23824356	Splice_Region	novel		0.55
SKCM	chr4	23828524	Silent	novel	L211L	0.32
SKCM	chr4	23813940	Missense_Mutation	rs374643892	E515K	0.41
SKCM	chr4	23813975	Missense_Mutation	NA	S503L	0.23
STAD	chr4	23829508	Silent	NA	H169H	0.08
STAD	chr4	23828506	Silent	rs753811432	N217N	0.21
STAD	chr4	23813927	Missense_Mutation	rs765713824	D519G	0.28
STAD	chr4	23828438	Frame_Shift_Del	novel	*K240Rfs23**	0.39
STAD	chr4	23828489	Missense_Mutation	NA	T223I	0.19
STAD	chr4	23831638	Silent	rs529427617	D116D	0.3
STAD	chr4	23801766	Missense_Mutation	rs748836875	R753C	0.1
STAD	chr4	23884874	Missense_Mutation	NA	L38V	0.13
STAD	chr4	23813780	Missense_Mutation	rs767722215	R568H	0.13
STAD	chr4	23812767	Missense_Mutation	NA	R667G	0.06
STAD	chr4	23890048	5'UTR	novel		0.29
STAD	chr4	23890015	5'UTR	novel		0.23
STAD	chr4	23814057	Missense_Mutation	rs143142906	D476N	0.1
STAD	chr4	23814183	Silent	NA	L434L	0.08
STAD	chr4	23812813	Silent	NA	R651R	0.36
STAD	chr4	23814043	Silent	NA	K480K	0.26
STAD	chr4	23814409	Silent	NA	L358L	0.18
STAD	chr4	23831601	Missense_Mutation	novel	P129S	0.33
STAD	chr4	23828416	Missense_Mutation	novel	Q247H	0.39
THCA	chr4	23831721	Missense_Mutation	novel	L89I	0.04
THCA	chr4	23831722	Missense_Mutation	novel	L88F	0.04
THCA	chr4	23831748	Missense_Mutation	rs757606579	I80V	0.41
THCA	chr4	23824382	Intron	novel		0.26
THYM	chr4	23813117	Missense_Mutation	novel	Y601C	0.49
UCEC	chr4	23795613	3'UTR	novel		0.2
UCEC	chr4	23795886	Missense_Mutation	novel	S778I	0.32
UCEC	chr4	23813792	Missense_Mutation	novel	R564M	0.17
UCEC	chr4	23795768	3'UTR	novel		0.07
UCEC	chr4	23795698	3'UTR	novel		0.29
UCEC	chr4	23792645	3'UTR	novel		0.37
UCEC	chr4	23801804	Missense_Mutation	novel	R740K	0.39
UCEC	chr4	23814371	Missense_Mutation	novel	R371M	0.37
UCEC	chr4	23814397	Silent	NA	S362S	0.15
UCEC	chr4	23831602	Missense_Mutation	novel	M128I	0.49
UCEC	chr4	23813755	Silent	novel	R576R	0.3
UCEC	chr4	23813078	Missense_Mutation	rs139240743	R614Q	0.52
UCEC	chr4	23828554	Missense_Mutation	novel	K201N	0.33
UCEC	chr4	23792502	3'UTR	novel		0.15
UCEC	chr4	23889962	5'UTR	novel		0.09
UCEC	chr4	23792976	3'UTR	novel		0.67
UCEC	chr4	23814252	Missense_Mutation	novel	E411K	0.33
UCEC	chr4	23792103	3'UTR	novel		0.22
UCEC	chr4	23795710	3'UTR	novel		0.21
UCEC	chr4	23793346	3'UTR	novel		0.38
UCEC	chr4	23813030	Missense_Mutation	rs372413128	R630H	0.05
UCEC	chr4	23812840	Silent	rs200822395	H642H	0.37
UCEC	chr4	23814601	Frame_Shift_Ins	novel	*T295Afs17**	0.12
UCEC	chr4	23814217	Frame_Shift_Ins	novel	*Q422Hfs55**	0.16
UCEC	chr4	23829514	Missense_Mutation	NA	Q167H	0.28
UCEC	chr4	23831653	Silent	rs747323735	A111A	0.23
UCEC	chr4	23814393	Missense_Mutation	novel	L364I	0.29
UCEC	chr4	23828544	Missense_Mutation	novel	R205C	0.19
UCEC	chr4	23884903	Missense_Mutation	novel	P28H	0.25
UCEC	chr4	23813753	Missense_Mutation	rs17847360	S577L	0.33
UCEC	chr4	23813096	Frame_Shift_Ins	novel	*Y608Lfs29**	0.02
UCEC	chr4	23824333	Missense_Mutation	novel	F275S	0.06
UCEC	chr4	23792102	3'UTR	novel		0.55
UCEC	chr4	23793181	3'UTR	novel		0.25
UCEC	chr4	23793959	3'UTR	novel		0.45
UCEC	chr4	23795084	3'UTR	novel		0.3
UCEC	chr4	23793147	3'UTR	novel		0.3
UCEC	chr4	23794179	3'UTR	novel		0.42
UCEC	chr4	23812756	Silent	novel	Q670Q	0.5
UCEC	chr4	23802335	Missense_Mutation	rs539338812	R677H	0.28
UCEC	chr4	23813942	Missense_Mutation	novel	S514I	0.38
UCEC	chr4	23814545	Missense_Mutation	novel	S313Y	0.38
UCEC	chr4	23813083	Silent	rs369563669	T612T	0.28
UCEC	chr4	23813728	Silent	novel	R585R	0.46
UCEC	chr4	23793091	3'UTR	novel		0.07
UCEC	chr4	23813095	In_Frame_Ins	novel	Y608_R609insCLLPLPLPLLGPL	0.03
UCEC	chr4	23813096	Frame_Shift_Ins	novel	*Y608Lfs29**	0.02
UCEC	chr4	23794081	3'UTR	novel		0.41
UCEC	chr4	23884910	Missense_Mutation	novel	D26Y	0.21
UCEC	chr4	23793075	3'UTR	novel		0.18
UCEC	chr4	23793870	3'UTR	novel		0.6
UCEC	chr4	23795155	3'UTR	novel		0.28
UCEC	chr4	23792380	3'UTR	novel		0.31
UCEC	chr4	23794961	3'UTR	novel		0.58
UCEC	chr4	23795607	3'UTR	novel		0.49
UCEC	chr4	23801840	Missense_Mutation	novel	A728D	0.41	RRM_1
UCEC	chr4	23831704	Missense_Mutation	novel	E94D	0.63
UCEC	chr4	23884799	Nonsense_Mutation	novel	E63*	0.43
UCEC	chr4	23802305	Frame_Shift_Ins	novel	*D687Afs21**	0.05	RRM_1
UCEC	chr4	23831565	Missense_Mutation	NA	P141S	0.31
UCEC	chr4	23795045	3'UTR	novel		0.41
UCEC	chr4	23824313	Missense_Mutation	rs781635737	R282C	0.48
UCEC	chr4	23793154	3'UTR	novel		0.36
UCEC	chr4	23801796	Missense_Mutation	rs767567742	E743K	0.35
UCEC	chr4	23802321	Missense_Mutation	rs776120045	G682S	0.24	RRM_1
UCEC	chr4	23814248	Missense_Mutation	novel	N412T	0.52
UCEC	chr4	23794117	3'UTR	novel		0.31
UCEC	chr4	23794804	3'UTR	novel		0.41
UCEC	chr4	23801786	Missense_Mutation	novel	F746S	0.15
UCEC	chr4	23814399	Missense_Mutation	novel	S362P	0.45
UCEC	chr4	23792036	3'UTR	novel		0.12
UCEC	chr4	23814572	Missense_Mutation	novel	A304D	0.16
UCEC	chr4	23884665	Intron	novel		0.26
UCEC	chr4	23792036	3'UTR	novel		0.3
UCEC	chr4	23792514	3'UTR	novel		0.38
UCEC	chr4	23792887	3'UTR	novel		0.67
UCEC	chr4	23792786	3'UTR	novel		0.44
UCEC	chr4	23792179	3'UTR	rs775665840		0.32
UCEC	chr4	23792428	3'UTR	novel		0.41
UCEC	chr4	23794654	3'UTR	novel		0.5
UCEC	chr4	23795725	3'UTR	novel		0.42
UCEC	chr4	23813694	Missense_Mutation	novel	S597A	0.39
UCEC	chr4	23814537	Silent	novel	L316L	0.33
UCEC	chr4	23795530	3'UTR	novel		0.33
UCEC	chr4	23795829	Missense_Mutation	rs200187877	R797H	0.33
UCEC	chr4	23813843	Missense_Mutation	novel	C547Y	0.38
UCEC	chr4	23792645	3'UTR	novel		0.26
UCEC	chr4	23793961	3'UTR	novel		0.38
UCEC	chr4	23813083	Silent	rs369563669	T612T	0.47
UCEC	chr4	23824351	Missense_Mutation	novel	D269G	0.39
UCEC	chr4	23831713	Silent	novel	V91V	0.39
UCEC	chr4	23795052	3'UTR	novel		0.44
UCEC	chr4	23795053	3'UTR	novel		0.44
UCEC	chr4	23792558	3'UTR	novel		0.46
UCEC	chr4	23794362	3'UTR	novel		0.42
UCEC	chr4	23794634	3'UTR	novel		0.42
UCEC	chr4	23813072	Missense_Mutation	novel	S616Y	0.31
UCEC	chr4	23884695	Intron	novel		0.47
UCEC	chr4	23795081	3'UTR	rs552213235		0.15
UCEC	chr4	23795508	3'UTR	novel		0.13
UCEC	chr4	23814338	Missense_Mutation	NA	G382A	0.33
UCEC	chr4	23794022	3'UTR	novel		0.36
UCEC	chr4	23814235	Silent	novel	S416S	0.34
UCEC	chr4	23889953	Missense_Mutation	rs771290152	A2V	0.13
UCEC	chr4	23828519	In_Frame_Ins	novel	Y213delinsLYLCQERFSPNHQD	0.04
UCEC	chr4	23828419	Silent	NA	S246S	0.2
UCEC	chr4	23793262	3'UTR	novel		0.19
UCEC	chr4	23795725	3'UTR	novel		0.29
UCEC	chr4	23792918	3'UTR	novel		0.4
UCEC	chr4	23794747	3'UTR	novel		0.2
UCEC	chr4	23812825	In_Frame_Ins	novel	R647delinsSDLERDLTYK	0.06
UCEC	chr4	23812827	Missense_Mutation	novel	R647G	0.02
UCEC	chr4	23812794	Nonsense_Mutation	novel	E658*	0.3
UCEC	chr4	23813941	Silent	rs529792659	S514S	0.23
UCEC	chr4	23831673	Missense_Mutation	novel	G105R	0.22
UCEC	chr4	23831638	Silent	rs529427617	D116D	0.44
UCEC	chr4	23793346	3'UTR	novel		0.54
UCEC	chr4	23793961	3'UTR	novel		0.24
UCEC	chr4	23795863	Missense_Mutation	novel	D786N	0.29
UCEC	chr4	23801807	Missense_Mutation	rs145169644	R739H	0.32	RRM_1
UCS	chr4	23884746	Splice_Region	novel		0.31
UCS	chr4	23813992	Silent	rs779716743	L497L	0.39
UCS	chr4	23884641	Intron	novel		0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	DEL	0.1973	0.14149

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
SARC	0.00034	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.014	Kaplan-Meier Survival Analysis
KIRP	0.00093	Kaplan-Meier Survival Analysis
COAD	0.0053	Kaplan-Meier Survival Analysis
BLCA	0.0052	Kaplan-Meier Survival Analysis
UCEC	0.00079	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0083	Kaplan-Meier Survival Analysis
THCA	0.014	Kaplan-Meier Survival Analysis
UVM	0.023	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000109819 (Gene tree)
Gene ID: 10891
Gene Symbol: PPARGC1A
Alias: PGC1|PGC1A|PGC-1alpha|PPARGC1
Full Name: PPARG coactivator 1 alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 717,731 bases
Position: chr4:23,755,041-24,472,771
Accession: 9237
RBP type: canonical RBP
Summary: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000481498	RRM_1	PF00076.22	7.3e-07	1	1
ENSP00000264867	RRM_1	PF00076.22	9e-07	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18673300	PGC-1alpha induces dynamic protein interactions on the ERRalpha gene multi-hormone response element nucleosome in kidney cells.	Biochem J	2008 Dec 15	Wang L	doi: 10.1042/BJ20081085.
30209975	Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.	Autophagy	2019 Jan	Yau WW	doi: 10.1080/15548627.2018.1511263
16267049	Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription.	J Biol Chem	2006 Jan 6	Herzog B	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000507342	PPARGC1A-205	359	-	-	- (aa)	-	-
ENST00000617484	PPARGC1A-218	1026	-	ENSP00000477921	297 (aa)	-	A0A087WTJ3
ENST00000509702	PPARGC1A-209	2704	-	-	- (aa)	-	-
ENST00000505469	PPARGC1A-203	406	-	-	- (aa)	-	-
ENST00000503714	PPARGC1A-202	380	-	-	- (aa)	-	-
ENST00000507380	PPARGC1A-206	2385	-	ENSP00000424181	99 (aa)	-	D6RBF3
ENST00000508380	PPARGC1A-207	576	-	-	- (aa)	-	-
ENST00000264867	PPARGC1A-201	6318	XM_005248131	ENSP00000264867	798 (aa)	XP_005248188	Q9UBK2
ENST00000515534	PPARGC1A-215	433	-	-	- (aa)	-	-
ENST00000513205	PPARGC1A-211	1432	-	ENSP00000421632	301 (aa)	-	Q9UBK2
ENST00000514517	PPARGC1A-214	548	-	-	- (aa)	-	-
ENST00000514479	PPARGC1A-212	324	-	-	- (aa)	-	-
ENST00000514494	PPARGC1A-213	529	-	-	- (aa)	-	-
ENST00000512169	PPARGC1A-210	550	-	-	- (aa)	-	-
ENST00000613098	PPARGC1A-217	3210	XM_011513766	ENSP00000481498	671 (aa)	XP_011512068	Q9UBK2
ENST00000612355	PPARGC1A-216	936	-	ENSP00000479729	267 (aa)	-	A0A087WVW3
ENST00000506055	PPARGC1A-204	2627	-	ENSP00000423075	271 (aa)	-	Q9UBK2
ENST00000509642	PPARGC1A-208	1391	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000109819's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04152	AMPK signaling pathway	KEGG
hsa04211	Longevity regulating pathway	KEGG
hsa04371	Apelin signaling pathway	KEGG
hsa04714	Thermogenesis	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04920	Adipocytokine signaling pathway	KEGG
hsa04922	Glucagon signaling pathway	KEGG
hsa04931	Insulin resistance	KEGG
hsa05016	Huntington disease	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000109819	Cholesterol, HDL	9.11565346408683E-5	17903299
ENSG00000109819	Cholesterol, HDL	8.92867062780578E-5	17903299
ENSG00000109819	Blood Pressure	5.04278146959727E-6	17903303
ENSG00000109819	Blood Pressure	8.19596529333388E-6	17903303
ENSG00000109819	Blood Pressure	8.58702893994373E-6	17903303
ENSG00000109819	Blood Pressure	1.01477958305285E-5	17903303
ENSG00000109819	Alkaline Phosphatase	5.09992075077292E-5	17903293
ENSG00000109819	Myocardial Infarction	7.3233145E-004	-
ENSG00000109819	Heart Failure	4.0505419E-004	-
ENSG00000109819	Stroke	3.4733485E-004	19369658
ENSG00000109819	Blood Pressure	1.137e-005	19060910
ENSG00000109819	Personality	3.327e-005	-
ENSG00000109819	Cardiovascular Physiological Phenomena	1.2830000E-005	-
ENSG00000109819	Cardiovascular Physiological Phenomena	4.2550000E-005	-
ENSG00000109819	Cardiovascular Physiological Phenomena	6.5600000E-005	-
ENSG00000109819	Lipoprotein(a)	8.6620000E-005	-
ENSG00000109819	Lipoprotein(a)	4.4610000E-005	-
ENSG00000109819	Lipoprotein(a)	7.7620000E-005	-
ENSG00000109819	Lipoprotein(a)	8.8630000E-005	-
ENSG00000109819	Monocytes	3.4470000E-005	-
ENSG00000109819	Platelet Count	1.2390000E-005	-
ENSG00000109819	Platelet Function Tests	2.8111000E-005	-
ENSG00000109819	Platelet Function Tests	2.3248900E-005	-
ENSG00000109819	Child Development Disorders, Pervasive	4.4000000E-005	-
ENSG00000109819	Erythrocyte Count	6.4500000E-006	-
ENSG00000109819	Tooth Demineralization	2E-6	23918034
ENSG00000109819	Smell	9E-6	26632684
ENSG00000109819	Cognition Disorders	1E-7	26252872
ENSG00000109819	Cognitive Dysfunction	1E-7	26252872
ENSG00000109819	Schizophrenia	1E-6	26198764
ENSG00000109819	Emphysema	2E-10	24383474
ENSG00000109819	Gout	1E-7	22179738
ENSG00000109819	Cognition Disorders	7E-8	26252872
ENSG00000109819	Cognitive Dysfunction	7E-8	26252872
ENSG00000109819	Longevity	6E-6	27015805
ENSG00000109819	Heart Rate	2E-15	27798624
ENSG00000109819	Essential Tremor	1E-9	27797806

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000109819	rs188794202	4	23848945	C	Cognitive decline rate in late mild cognitive impairment	26252872	[0.36-0.78] unit decrease	0.5678	HP_0100543\|EFO_0007710
ENSG00000109819	rs41359445	4	23792721	A	Cognitive decline rate in late mild cognitive impairment	26252872	[0.39-0.83] unit decrease	0.6109	HP_0100543\|EFO_0007710
ENSG00000109819	rs768695	4	23797195	?	Reaction time	29844566	[0.0044-0.0113] unit decrease	0.0078592	EFO_0008393
ENSG00000109819	rs2970870	4	23891394	?	Red blood cell count	30595370			EFO_0004305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000109819's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000109819	PPARGC1A	55	51.908	ENSG00000155846	PPARGC1B	50	51.908

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000109819	PPARGC1A	96	70.205	ENSAPOG00000018632	ppargc1a	100	56.588	Acanthochromis_polyacanthus
ENSG00000109819	PPARGC1A	68	49.630	ENSAMEG00000005287	PPARGC1B	52	49.630	Ailuropoda_melanoleuca
ENSG00000109819	PPARGC1A	99	98.134	ENSAMEG00000010421	PPARGC1A	100	96.366	Ailuropoda_melanoleuca
ENSG00000109819	PPARGC1A	96	70.205	ENSAOCG00000006754	ppargc1a	100	56.522	Amphiprion_ocellaris
ENSG00000109819	PPARGC1A	96	70.205	ENSAPEG00000022574	ppargc1a	100	55.401	Amphiprion_percula
ENSG00000109819	PPARGC1A	96	69.360	ENSATEG00000016702	ppargc1a	100	54.472	Anabas_testudineus
ENSG00000109819	PPARGC1A	100	88.722	ENSAPLG00000005303	PPARGC1A	100	88.722	Anas_platyrhynchos
ENSG00000109819	PPARGC1A	69	49.265	ENSACAG00000015737	PPARGC1B	52	49.265	Anolis_carolinensis
ENSG00000109819	PPARGC1A	99	88.433	ENSACAG00000000741	PPARGC1A	100	83.396	Anolis_carolinensis
ENSG00000109819	PPARGC1A	100	99.373	ENSANAG00000035930	PPARGC1A	100	99.373	Aotus_nancymaae
ENSG00000109819	PPARGC1A	53	51.908	ENSANAG00000021830	PPARGC1B	50	51.908	Aotus_nancymaae
ENSG00000109819	PPARGC1A	96	69.024	ENSACLG00000001002	ppargc1a	86	70.306	Astatotilapia_calliptera
ENSG00000109819	PPARGC1A	85	92.000	ENSAMXG00000002461	ppargc1a	99	56.407	Astyanax_mexicanus
ENSG00000109819	PPARGC1A	99	97.761	ENSBTAG00000017024	PPARGC1A	100	94.869	Bos_taurus
ENSG00000109819	PPARGC1A	100	98.997	ENSCJAG00000013024	PPARGC1A	100	98.997	Callithrix_jacchus
ENSG00000109819	PPARGC1A	68	48.529	ENSCAFG00000018275	PPARGC1B	53	48.529	Canis_familiaris
ENSG00000109819	PPARGC1A	99	98.134	ENSCAFG00000016519	PPARGC1A	100	96.742	Canis_familiaris
ENSG00000109819	PPARGC1A	100	96.572	ENSCAFG00020027242	PPARGC1A	99	96.891	Canis_lupus_dingo
ENSG00000109819	PPARGC1A	64	42.857	ENSCAFG00020023524	PPARGC1B	51	48.529	Canis_lupus_dingo
ENSG00000109819	PPARGC1A	99	97.761	ENSCHIG00000015991	PPARGC1A	100	94.994	Capra_hircus
ENSG00000109819	PPARGC1A	56	47.826	ENSCHIG00000004409	PPARGC1B	53	47.794	Capra_hircus
ENSG00000109819	PPARGC1A	66	48.092	ENSTSYG00000034354	PPARGC1B	53	48.092	Carlito_syrichta
ENSG00000109819	PPARGC1A	100	98.997	ENSTSYG00000010439	PPARGC1A	100	98.997	Carlito_syrichta
ENSG00000109819	PPARGC1A	100	91.654	ENSCAPG00000005150	PPARGC1A	96	92.718	Cavia_aperea
ENSG00000109819	PPARGC1A	55	49.020	ENSCPOG00000001958	PPARGC1B	53	48.120	Cavia_porcellus
ENSG00000109819	PPARGC1A	99	97.015	ENSCPOG00000001518	PPARGC1A	100	95.990	Cavia_porcellus
ENSG00000109819	PPARGC1A	100	98.872	ENSCCAG00000024681	PPARGC1A	100	98.872	Cebus_capucinus
ENSG00000109819	PPARGC1A	65	51.145	ENSCATG00000030402	PPARGC1B	50	51.145	Cercocebus_atys
ENSG00000109819	PPARGC1A	100	99.624	ENSCATG00000032575	PPARGC1A	100	99.624	Cercocebus_atys
ENSG00000109819	PPARGC1A	99	97.015	ENSCLAG00000002058	PPARGC1A	100	95.865	Chinchilla_lanigera
ENSG00000109819	PPARGC1A	65	49.630	ENSCLAG00000015452	PPARGC1B	54	49.630	Chinchilla_lanigera
ENSG00000109819	PPARGC1A	100	99.624	ENSCSAG00000016575	PPARGC1A	100	99.624	Chlorocebus_sabaeus
ENSG00000109819	PPARGC1A	100	99.499	ENSCANG00000033426	PPARGC1A	100	99.499	Colobus_angolensis_palliatus
ENSG00000109819	PPARGC1A	56	52.128	ENSCGRG00001017949	Ppargc1b	53	46.753	Cricetulus_griseus_chok1gshd
ENSG00000109819	PPARGC1A	99	95.896	ENSCGRG00001015534	Ppargc1a	100	94.862	Cricetulus_griseus_chok1gshd
ENSG00000109819	PPARGC1A	99	95.896	ENSCGRG00000000200	Ppargc1a	100	94.862	Cricetulus_griseus_crigri
ENSG00000109819	PPARGC1A	54	52.128	ENSCGRG00000008387	Ppargc1b	52	48.905	Cricetulus_griseus_crigri
ENSG00000109819	PPARGC1A	96	69.178	ENSCSEG00000006884	ppargc1a	79	82.927	Cynoglossus_semilaevis
ENSG00000109819	PPARGC1A	79	83.333	ENSCVAG00000016547	ppargc1a	64	78.659	Cyprinodon_variegatus
ENSG00000109819	PPARGC1A	70	34.694	ENSDARG00000101569	ppargc1b	54	40.984	Danio_rerio
ENSG00000109819	PPARGC1A	87	80.337	ENSDARG00000067829	ppargc1a	90	82.317	Danio_rerio
ENSG00000109819	PPARGC1A	100	96.241	ENSDNOG00000041106	PPARGC1A	100	96.241	Dasypus_novemcinctus
ENSG00000109819	PPARGC1A	100	95.529	ENSDORG00000016276	Ppargc1a	98	95.780	Dipodomys_ordii
ENSG00000109819	PPARGC1A	100	97.317	ENSEASG00005007984	PPARGC1A	100	97.243	Equus_asinus_asinus
ENSG00000109819	PPARGC1A	100	97.466	ENSECAG00000009164	PPARGC1A	98	96.827	Equus_caballus
ENSG00000109819	PPARGC1A	94	96.800	ENSEEUG00000009219	PPARGC1A	100	89.629	Erinaceus_europaeus
ENSG00000109819	PPARGC1A	81	92.000	ENSELUG00000017027	ppargc1a	100	52.058	Esox_lucius
ENSG00000109819	PPARGC1A	99	97.388	ENSFCAG00000000043	PPARGC1A	100	96.241	Felis_catus
ENSG00000109819	PPARGC1A	100	87.183	ENSFALG00000009211	PPARGC1A	99	87.580	Ficedula_albicollis
ENSG00000109819	PPARGC1A	63	48.921	ENSFALG00000008858	PPARGC1B	58	48.921	Ficedula_albicollis
ENSG00000109819	PPARGC1A	99	97.388	ENSFDAG00000005659	PPARGC1A	100	95.614	Fukomys_damarensis
ENSG00000109819	PPARGC1A	64	42.857	ENSFDAG00000008719	PPARGC1B	53	48.855	Fukomys_damarensis
ENSG00000109819	PPARGC1A	96	69.178	ENSFHEG00000021990	ppargc1a	100	52.241	Fundulus_heteroclitus
ENSG00000109819	PPARGC1A	100	88.596	ENSGALG00000042851	PPARGC1A	100	88.596	Gallus_gallus
ENSG00000109819	PPARGC1A	94	76.596	ENSGAFG00000015514	ppargc1a	100	53.513	Gambusia_affinis
ENSG00000109819	PPARGC1A	100	86.587	ENSGAGG00000007043	PPARGC1A	100	86.684	Gopherus_agassizii
ENSG00000109819	PPARGC1A	57	50.000	ENSGAGG00000012870	PPARGC1B	60	50.000	Gopherus_agassizii
ENSG00000109819	PPARGC1A	100	99.749	ENSGGOG00000009810	PPARGC1A	100	99.749	Gorilla_gorilla
ENSG00000109819	PPARGC1A	55	51.908	ENSGGOG00000009505	PPARGC1B	51	51.908	Gorilla_gorilla
ENSG00000109819	PPARGC1A	96	69.024	ENSHBUG00000005269	ppargc1a	99	84.375	Haplochromis_burtoni
ENSG00000109819	PPARGC1A	54	50.000	ENSHGLG00000005967	PPARGC1B	55	48.889	Heterocephalus_glaber_female
ENSG00000109819	PPARGC1A	100	96.423	ENSHGLG00000007022	PPARGC1A	100	96.923	Heterocephalus_glaber_female
ENSG00000109819	PPARGC1A	100	96.491	ENSHGLG00100000133	PPARGC1A	100	96.491	Heterocephalus_glaber_male
ENSG00000109819	PPARGC1A	79	80.769	ENSHCOG00000014886	ppargc1a	91	79.878	Hippocampus_comes
ENSG00000109819	PPARGC1A	100	95.990	ENSSTOG00000012522	PPARGC1A	100	95.990	Ictidomys_tridecemlineatus
ENSG00000109819	PPARGC1A	96	68.601	ENSKMAG00000005390	ppargc1a	91	81.098	Kryptolebias_marmoratus
ENSG00000109819	PPARGC1A	95	71.368	ENSLBEG00000019562	ppargc1a	85	71.368	Labrus_bergylta
ENSG00000109819	PPARGC1A	91	35.047	ENSLACG00000011232	PPARGC1B	69	48.322	Latimeria_chalumnae
ENSG00000109819	PPARGC1A	98	76.014	ENSLACG00000014054	PPARGC1A	99	72.321	Latimeria_chalumnae
ENSG00000109819	PPARGC1A	69	37.824	ENSLOCG00000012195	ppargc1b	57	42.105	Lepisosteus_oculatus
ENSG00000109819	PPARGC1A	98	66.981	ENSLOCG00000012350	ppargc1a	100	63.290	Lepisosteus_oculatus
ENSG00000109819	PPARGC1A	100	95.113	ENSLAFG00000012981	PPARGC1A	100	95.113	Loxodonta_africana
ENSG00000109819	PPARGC1A	57	48.529	ENSLAFG00000012339	PPARGC1B	55	48.529	Loxodonta_africana
ENSG00000109819	PPARGC1A	53	51.145	ENSMFAG00000042269	PPARGC1B	51	51.145	Macaca_fascicularis
ENSG00000109819	PPARGC1A	100	99.123	ENSMFAG00000000534	PPARGC1A	100	99.123	Macaca_fascicularis
ENSG00000109819	PPARGC1A	53	51.145	ENSMMUG00000004749	PPARGC1B	51	51.145	Macaca_mulatta
ENSG00000109819	PPARGC1A	100	99.248	ENSMMUG00000001844	PPARGC1A	100	99.248	Macaca_mulatta
ENSG00000109819	PPARGC1A	100	99.248	ENSMNEG00000028682	PPARGC1A	100	99.248	Macaca_nemestrina
ENSG00000109819	PPARGC1A	53	51.145	ENSMNEG00000034121	PPARGC1B	51	51.145	Macaca_nemestrina
ENSG00000109819	PPARGC1A	100	99.624	ENSMLEG00000034233	PPARGC1A	100	99.624	Mandrillus_leucophaeus
ENSG00000109819	PPARGC1A	53	51.145	ENSMLEG00000040973	PPARGC1B	52	51.145	Mandrillus_leucophaeus
ENSG00000109819	PPARGC1A	86	88.000	ENSMAMG00000005531	ppargc1a	100	53.015	Mastacembelus_armatus
ENSG00000109819	PPARGC1A	94	70.370	ENSMZEG00005001739	ppargc1a	70	70.370	Maylandia_zebra
ENSG00000109819	PPARGC1A	100	88.471	ENSMGAG00000012485	PPARGC1A	100	88.471	Meleagris_gallopavo
ENSG00000109819	PPARGC1A	62	44.545	ENSMGAG00000003134	PPARGC1B	50	44.545	Meleagris_gallopavo
ENSG00000109819	PPARGC1A	99	95.896	ENSMAUG00000011811	Ppargc1a	100	94.737	Mesocricetus_auratus
ENSG00000109819	PPARGC1A	71	47.403	ENSMAUG00000014191	Ppargc1b	54	47.403	Mesocricetus_auratus
ENSG00000109819	PPARGC1A	55	51.020	ENSMICG00000002702	PPARGC1B	52	49.265	Microcebus_murinus
ENSG00000109819	PPARGC1A	100	97.619	ENSMICG00000015390	PPARGC1A	100	97.619	Microcebus_murinus
ENSG00000109819	PPARGC1A	99	95.522	ENSMOCG00000008765	Ppargc1a	100	94.361	Microtus_ochrogaster
ENSG00000109819	PPARGC1A	71	44.805	ENSMOCG00000014885	Ppargc1b	55	44.805	Microtus_ochrogaster
ENSG00000109819	PPARGC1A	80	84.242	ENSMMOG00000011847	ppargc1a	98	84.146	Mola_mola
ENSG00000109819	PPARGC1A	100	91.103	ENSMODG00000000549	PPARGC1A	100	91.103	Monodelphis_domestica
ENSG00000109819	PPARGC1A	79	82.051	ENSMALG00000004625	ppargc1a	85	78.659	Monopterus_albus
ENSG00000109819	PPARGC1A	56	51.042	MGP_CAROLIEiJ_G0022323	Ppargc1b	53	44.156	Mus_caroli
ENSG00000109819	PPARGC1A	99	96.269	MGP_CAROLIEiJ_G0027213	Ppargc1a	100	94.361	Mus_caroli
ENSG00000109819	PPARGC1A	99	96.283	ENSMUSG00000029167	Ppargc1a	100	94.493	Mus_musculus
ENSG00000109819	PPARGC1A	55	52.128	ENSMUSG00000033871	Ppargc1b	52	44.156	Mus_musculus
ENSG00000109819	PPARGC1A	99	96.269	MGP_PahariEiJ_G0016995	Ppargc1a	100	94.486	Mus_pahari
ENSG00000109819	PPARGC1A	57	51.064	MGP_PahariEiJ_G0019053	Ppargc1b	54	44.156	Mus_pahari
ENSG00000109819	PPARGC1A	99	96.283	MGP_SPRETEiJ_G0028208	Ppargc1a	100	94.243	Mus_spretus
ENSG00000109819	PPARGC1A	56	52.128	MGP_SPRETEiJ_G0023235	Ppargc1b	53	44.156	Mus_spretus
ENSG00000109819	PPARGC1A	54	52.688	ENSMPUG00000014245	PPARGC1B	52	48.529	Mustela_putorius_furo
ENSG00000109819	PPARGC1A	99	97.761	ENSMPUG00000016736	PPARGC1A	100	95.489	Mustela_putorius_furo
ENSG00000109819	PPARGC1A	99	97.015	ENSMLUG00000016307	PPARGC1A	100	95.865	Myotis_lucifugus
ENSG00000109819	PPARGC1A	100	94.236	ENSNGAG00000015090	Ppargc1a	100	94.236	Nannospalax_galili
ENSG00000109819	PPARGC1A	100	99.702	ENSNLEG00000016760	PPARGC1A	100	99.702	Nomascus_leucogenys
ENSG00000109819	PPARGC1A	56	51.042	ENSNLEG00000010193	PPARGC1B	51	48.201	Nomascus_leucogenys
ENSG00000109819	PPARGC1A	66	49.618	ENSOPRG00000010017	PPARGC1B	52	47.794	Ochotona_princeps
ENSG00000109819	PPARGC1A	100	94.635	ENSOPRG00000012899	PPARGC1A	100	94.612	Ochotona_princeps
ENSG00000109819	PPARGC1A	96	63.787	ENSONIG00000007635	ppargc1a	100	55.217	Oreochromis_niloticus
ENSG00000109819	PPARGC1A	99	89.925	ENSOANG00000006680	PPARGC1A	100	88.847	Ornithorhynchus_anatinus
ENSG00000109819	PPARGC1A	62	48.889	ENSOANG00000009368	PPARGC1B	51	48.889	Ornithorhynchus_anatinus
ENSG00000109819	PPARGC1A	100	94.987	ENSOCUG00000014668	PPARGC1A	100	94.987	Oryctolagus_cuniculus
ENSG00000109819	PPARGC1A	73	38.647	ENSOCUG00000013833	PPARGC1B	53	44.604	Oryctolagus_cuniculus
ENSG00000109819	PPARGC1A	91	78.947	ENSORLG00000004788	ppargc1a	100	54.675	Oryzias_latipes
ENSG00000109819	PPARGC1A	91	77.895	ENSORLG00020014690	ppargc1a	100	51.740	Oryzias_latipes_hni
ENSG00000109819	PPARGC1A	91	78.421	ENSORLG00015012206	ppargc1a	90	82.051	Oryzias_latipes_hsok
ENSG00000109819	PPARGC1A	96	69.863	ENSOMEG00000000670	ppargc1a	91	81.098	Oryzias_melastigma
ENSG00000109819	PPARGC1A	99	97.761	ENSOGAG00000014559	PPARGC1A	100	96.115	Otolemur_garnettii
ENSG00000109819	PPARGC1A	99	97.761	ENSOARG00000005581	PPARGC1A	97	95.119	Ovis_aries
ENSG00000109819	PPARGC1A	55	51.908	ENSPPAG00000035226	PPARGC1B	51	51.908	Pan_paniscus
ENSG00000109819	PPARGC1A	100	99.702	ENSPPAG00000034694	PPARGC1A	100	99.702	Pan_paniscus
ENSG00000109819	PPARGC1A	99	97.388	ENSPPRG00000001711	PPARGC1A	100	96.241	Panthera_pardus
ENSG00000109819	PPARGC1A	99	97.388	ENSPTIG00000007378	PPARGC1A	100	96.241	Panthera_tigris_altaica
ENSG00000109819	PPARGC1A	53	51.908	ENSPTRG00000017403	PPARGC1B	50	51.908	Pan_troglodytes
ENSG00000109819	PPARGC1A	100	99.749	ENSPTRG00000015954	PPARGC1A	100	99.749	Pan_troglodytes
ENSG00000109819	PPARGC1A	99	100.000	ENSPANG00000005420	PPARGC1A	100	98.498	Papio_anubis
ENSG00000109819	PPARGC1A	53	51.145	ENSPANG00000009512	PPARGC1B	51	51.145	Papio_anubis
ENSG00000109819	PPARGC1A	81	37.838	ENSPSIG00000008358	PPARGC1B	57	45.223	Pelodiscus_sinensis
ENSG00000109819	PPARGC1A	100	88.376	ENSPSIG00000011790	PPARGC1A	100	88.346	Pelodiscus_sinensis
ENSG00000109819	PPARGC1A	79	83.333	ENSPMGG00000019204	ppargc1a	100	51.007	Periophthalmus_magnuspinnatus
ENSG00000109819	PPARGC1A	72	46.104	ENSPEMG00000018822	Ppargc1b	56	46.104	Peromyscus_maniculatus_bairdii
ENSG00000109819	PPARGC1A	100	95.119	ENSPEMG00000010892	Ppargc1a	100	95.119	Peromyscus_maniculatus_bairdii
ENSG00000109819	PPARGC1A	99	91.791	ENSPCIG00000015835	PPARGC1A	100	89.850	Phascolarctos_cinereus
ENSG00000109819	PPARGC1A	90	75.510	ENSPFOG00000001263	ppargc1a	92	79.878	Poecilia_formosa
ENSG00000109819	PPARGC1A	86	88.000	ENSPMEG00000000720	ppargc1a	79	79.878	Poecilia_mexicana
ENSG00000109819	PPARGC1A	100	99.875	ENSPPYG00000014640	PPARGC1A	100	99.875	Pongo_abelii
ENSG00000109819	PPARGC1A	55	52.308	ENSPPYG00000015938	PPARGC1B	50	52.308	Pongo_abelii
ENSG00000109819	PPARGC1A	99	95.896	ENSPCAG00000016308	PPARGC1A	100	92.982	Procavia_capensis
ENSG00000109819	PPARGC1A	100	97.494	ENSPCOG00000022858	PPARGC1A	100	97.494	Propithecus_coquereli
ENSG00000109819	PPARGC1A	61	45.000	ENSPCOG00000024059	PPARGC1B	52	50.000	Propithecus_coquereli
ENSG00000109819	PPARGC1A	54	52.128	ENSPVAG00000001308	PPARGC1B	52	47.794	Pteropus_vampyrus
ENSG00000109819	PPARGC1A	99	97.761	ENSPVAG00000004965	PPARGC1A	100	96.617	Pteropus_vampyrus
ENSG00000109819	PPARGC1A	96	69.024	ENSPNYG00000006846	ppargc1a	70	70.782	Pundamilia_nyererei
ENSG00000109819	PPARGC1A	85	92.000	ENSPNAG00000010393	ppargc1a	100	55.127	Pygocentrus_nattereri
ENSG00000109819	PPARGC1A	99	97.015	ENSRNOG00000004473	Ppargc1a	100	95.113	Rattus_norvegicus
ENSG00000109819	PPARGC1A	67	47.059	ENSRNOG00000017503	Ppargc1b	54	47.059	Rattus_norvegicus
ENSG00000109819	PPARGC1A	100	99.373	ENSRBIG00000032333	PPARGC1A	100	99.373	Rhinopithecus_bieti
ENSG00000109819	PPARGC1A	57	46.429	ENSRROG00000029594	PPARGC1B	51	51.145	Rhinopithecus_roxellana
ENSG00000109819	PPARGC1A	100	99.499	ENSRROG00000010419	PPARGC1A	100	99.499	Rhinopithecus_roxellana
ENSG00000109819	PPARGC1A	100	99.123	ENSSBOG00000006423	PPARGC1A	100	99.123	Saimiri_boliviensis_boliviensis
ENSG00000109819	PPARGC1A	100	91.353	ENSSHAG00000010033	PPARGC1A	96	91.353	Sarcophilus_harrisii
ENSG00000109819	PPARGC1A	79	82.051	ENSSFOG00015001633	ppargc1a	86	62.651	Scleropages_formosus
ENSG00000109819	PPARGC1A	92	76.596	ENSSMAG00000011571	ppargc1a	100	55.855	Scophthalmus_maximus
ENSG00000109819	PPARGC1A	96	69.863	ENSSDUG00000007408	ppargc1a	100	55.054	Seriola_dumerili
ENSG00000109819	PPARGC1A	79	83.333

EuRBPDB

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

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Expression

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GWAS

PPI

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.