EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
12421917	Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells.	J Immunol	2002 Nov 15	Noessner E	-
18772114	Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.	Cancer Cell	2008 Sep 9	Powers MV	doi: 10.1016/j.ccr.2008.08.002.
26229111	Characterization of Aes nuclear foci in colorectal cancer cells.	J Biochem	2016 Jan	Itatani Y	doi: 10.1093/jb/mvv077
23065205	HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case-control study.	Mol Biol Rep	2012 Dec	Zagouri F	doi: 10.1007/s11033-012-1984-2
24327656	The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.	J Biol Chem	2014 Jan 31	Connarn JN	doi: 10.1074/jbc.M113.519421
24736948	Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-specic apoptosis.	Int J Oncol	2014 Jul	Wang H	doi: 10.3892/ijo.2014.2388
19802014	Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells.	Oncogene	2010 Jan 7	Nird?? P	doi: 10.1038/onc.2009.311
15336565	Expression of methionine aminopeptidase 2, N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29.	Biochem Biophys Res Commun	2004 Sep 24	Selvakumar P	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr11	123058681	Silent	novel	V491V	0.46
ACC	chr11	123058683	Missense_Mutation	novel	V491L	0.46
BLCA	chr11	123059941	Missense_Mutation	novel	E218Q	0.18
BLCA	chr11	123061175	Silent	NA	L50L	0.3
BLCA	chr11	123060300	Intron	novel		0.16
BLCA	chr11	123059663	Silent	novel	F310F	0.37
BLCA	chr11	123059830	Nonsense_Mutation	novel	E255*	0.1
BLCA	chr11	123061226	Silent	novel	Q33Q	0.48
BLCA	chr11	123057779	Silent	NA	P632P	0.16
BLCA	chr11	123057749	Silent	novel	I642I	0.34
BLCA	chr11	123059639	Missense_Mutation	novel	E318D	0.84
BLCA	chr11	123057745	Missense_Mutation	NA	E644K	0.21
BLCA	chr11	123058694	Missense_Mutation	rs749707173	N487S	0.15
BLCA	chr11	123057778	Frame_Shift_Ins	novel	*S633Lfs11**	0.42
BLCA	chr11	123058827	Missense_Mutation	NA	Y443H	0.34
BLCA	chr11	123058425	Missense_Mutation	novel	E528K	0.47
BLCA	chr11	123059830	Missense_Mutation	novel	E255K	0.56
BLCA	chr11	123060019	Missense_Mutation	NA	E192Q	0.51
BLCA	chr11	123058709	Missense_Mutation	NA	A482V	0.43
BRCA	chr11	123058762	Missense_Mutation	NA	I464M	0.41
BRCA	chr11	123059897	Missense_Mutation	NA	D232E	0.13
BRCA	chr11	123058735	Missense_Mutation	novel	Q473H	0.57
BRCA	chr11	123061254	Missense_Mutation	NA	G24E	0.21
BRCA	chr11	123058771	Silent	NA	L461L	0.76
BRCA	chr11	123059586	In_Frame_Del	NA	L336del	0.35
BRCA	chr11	123061117	Splice_Region	novel		0.46
BRCA	chr11	123061153	Missense_Mutation	novel	Q58E	0.19
CESC	chr11	123058281	Missense_Mutation	novel	E576K	0.32
CESC	chr11	123058312	Missense_Mutation	NA	E565D	0.5
CESC	chr11	123058263	Missense_Mutation	NA	D582N	0.17
CESC	chr11	123057739	Missense_Mutation	NA	D646H	0.15
CESC	chr11	123061213	Missense_Mutation	novel	T38A	0.41
CESC	chr11	123059143	Silent	novel	L413L	0.19
CESC	chr11	123060743	Missense_Mutation	NA	M87I	0.48
CESC	chr11	123060785	Silent	NA	L73L	0.19
CESC	chr11	123061294	Missense_Mutation	novel	L11F	0.28
CHOL	chr11	123061239	Missense_Mutation	novel	I29S	0.65
COAD	chr11	123059290	Intron	novel		0.37
COAD	chr11	123058377	Missense_Mutation	novel	S544P	0.22
COAD	chr11	123059984	Silent	novel	G203G	0.49
COAD	chr11	123060734	Nonsense_Mutation	novel	W90*	0.16
COAD	chr11	123058337	Missense_Mutation	NA	K557T	0.31
COAD	chr11	123059741	Silent	rs148846437	I284I	0.25
COAD	chr11	123059135	Missense_Mutation	NA	R416H	0.38
COAD	chr11	123058302	Frame_Shift_Del	NA	*K569Dfs6**	0.3
COAD	chr11	123058279	Missense_Mutation	novel	E576D	0.28
COAD	chr11	123057734	Nonstop_Mutation	novel	647Yext5	0.24
COAD	chr11	123057810	In_Frame_Del	novel	M621_G624del	0.28
ESCA	chr11	123057892	Missense_Mutation	novel	Q595E	0.35
ESCA	chr11	123057792	Missense_Mutation	novel	G628D	0.07
GBM	chr11	123060355	Intron	novel		0.25
HNSC	chr11	123059939	Silent	novel	E218E	0.14
HNSC	chr11	123057757	Missense_Mutation	novel	P640S	0.71
HNSC	chr11	123058832	Splice_Region	novel		0.16
HNSC	chr11	123060676	Missense_Mutation	novel	E110Q	0.09
HNSC	chr11	123057885	Missense_Mutation	novel	K597I	0.35
HNSC	chr11	123058746	Frame_Shift_Ins	novel	*G470Rfs6**	0.07
HNSC	chr11	123058748	Missense_Mutation	novel	R469P	0.13
HNSC	chr11	123060198	Missense_Mutation	novel	A161D	0.16
HNSC	chr11	123059662	Missense_Mutation	novel	R311C	0.31
HNSC	chr11	123059677	Missense_Mutation	novel	N306D	0.21
HNSC	chr11	123057816	In_Frame_Del	rs765426437	M621_G624del	0.17
HNSC	chr11	123059657	Silent	novel	G312G	0.33
KICH	chr11	123060695	Silent	rs751477695	V103V	0.04
KIRC	chr11	123059568	Missense_Mutation	NA	R342P	0.14
KIRC	chr11	123059554	Nonsense_Mutation	NA	Q347*	0.32
KIRC	chr11	123059556	Missense_Mutation	NA	I346N	0.34
KIRC	chr11	123061289	Silent	rs536070549	G12G	0.23
KIRC	chr11	123061267	Missense_Mutation	NA	V20L	0.26
KIRC	chr11	123060190	Missense_Mutation	NA	I164V	0.4
KIRC	chr11	123060264	Frame_Shift_Ins	novel	*V139Gfs50**	0.11
KIRC	chr11	123059960	Silent	rs756568266	T211T	0.3
KIRC	chr11	123061133	Silent	NA	T64T	0.28
KIRC	chr11	123060221	Silent	NA	S153S	0.42
KIRC	chr11	123058697	Missense_Mutation	NA	L486P	0.21
KIRC	chr11	123060293	Intron	novel		0.38
KIRP	chr11	123060254	Silent	novel	A142A	0.54
KIRP	chr11	123059056	Splice_Region	novel		0.12
KIRP	chr11	123060232	Missense_Mutation	NA	F150L	0.44
KIRP	chr11	123061269	Missense_Mutation	novel	G19A	0.57
KIRP	chr11	123058670	In_Frame_Ins	novel	K493_S494dup	0.11
LAML	chr11	123060096	Intron	novel		0.1
LAML	chr11	123060600	Missense_Mutation	novel	L135R	0.09
LGG	chr11	123057790	Missense_Mutation	NA	G629R	0.34
LIHC	chr11	123059117	Missense_Mutation	novel	T422N	0.3
LIHC	chr11	123061139	Silent	NA	N62N	0.14
LIHC	chr11	123059514	Missense_Mutation	rs756920138	N360S	0.09
LUAD	chr11	123059683	Missense_Mutation	NA	E304K	0.2
LUAD	chr11	123060205	Missense_Mutation	NA	K159E	0.27
LUAD	chr11	123057820	Frame_Shift_Ins	novel	*G619Rfs25**	0.47
LUAD	chr11	123058656	Nonsense_Mutation	novel	K500*	0.46
LUAD	chr11	123060652	Nonsense_Mutation	NA	E118*	0.19
LUAD	chr11	123060116	Splice_Region	NA	K188K	0.08
LUAD	chr11	123057608	3'UTR	novel		0.43
LUAD	chr11	123061249	Missense_Mutation	novel	V26I	0.12
LUAD	chr11	123059998	Missense_Mutation	novel	D199Y	0.28
LUAD	chr11	123060676	Missense_Mutation	novel	E110K	0.12
LUAD	chr11	123061254	Missense_Mutation	NA	G24E	0.09
LUAD	chr11	123059985	Missense_Mutation	NA	G203D	0.29
LUAD	chr11	123061180	Missense_Mutation	NA	R49W	0.47
LUAD	chr11	123058807	Missense_Mutation	novel	M449I	0.07
LUAD	chr11	123059998	Missense_Mutation	novel	D199N	0.12
LUSC	chr11	123058411	Missense_Mutation	novel	Q532H	0.16
LUSC	chr11	123059952	Missense_Mutation	novel	D214G	0.1
LUSC	chr11	123058660	Silent	novel	E498E	0.06
LUSC	chr11	123058258	Frame_Shift_Ins	novel	*N584Efs5**	0.33
LUSC	chr11	123058391	Missense_Mutation	novel	K539M	0.37
LUSC	chr11	123058750	Silent	NA	P468P	0.13
LUSC	chr11	123058267	Missense_Mutation	NA	W580C	0.29
LUSC	chr11	123060121	Missense_Mutation	novel	K187E	0.09
LUSC	chr11	123060328	Intron	novel		0.19
LUSC	chr11	123058823	Missense_Mutation	novel	E444V	0.1
OV	chr11	123060135	Frame_Shift_Ins	novel	*A182Vfs18**	0.31
OV	chr11	123060136	Frame_Shift_Ins	novel	*A182Pfs14**	0.3
OV	chr11	123059460	Intron	novel		0.11
OV	chr11	123059585	Frame_Shift_Del	NA	*D333Gfs25**	0.46
OV	chr11	123059912	Silent	novel	H227H	0.12
PAAD	chr11	123059680	Missense_Mutation	novel	L305M	0.16
PAAD	chr11	123060786	Missense_Mutation	novel	L73P	0.21
PRAD	chr11	123060261	Missense_Mutation	rs141156763	T140N	0.09
PRAD	chr11	123058694	Missense_Mutation	rs749707173	N487S	0.12
PRAD	chr11	123060640	Missense_Mutation	novel	M122V	0.15
PRAD	chr11	123058705	Missense_Mutation	NA	N483K	0.32
PRAD	chr11	123059792	Missense_Mutation	novel	C267W	0.16
PRAD	chr11	123058278	Missense_Mutation	NA	I577V	0.33
PRAD	chr11	123059502	Missense_Mutation	novel	N364S	0.1
READ	chr11	123059550	Missense_Mutation	NA	K348T	0.32
READ	chr11	123058460	Missense_Mutation	NA	E516G	0.07
READ	chr11	123059658	Missense_Mutation	NA	G312A	0.39
READ	chr11	123060292	Intron	novel		0.39
READ	chr11	123061123	Missense_Mutation	NA	F68I	0.44
SARC	chr11	123057689	3'UTR	novel		0.19
SKCM	chr11	123057799	Missense_Mutation	NA	P626S	0.22
SKCM	chr11	123058324	Silent	NA	K561K	0.09
SKCM	chr11	123058271	Missense_Mutation	novel	N579S	0.85
SKCM	chr11	123059356	Intron	novel		0.78
SKCM	chr11	123061157	Silent	novel	K56K	0.51
SKCM	chr11	123057672	3'UTR	novel		0.25
SKCM	chr11	123061142	Missense_Mutation	NA	M61I	0.78
SKCM	chr11	123060626	Silent	rs374961418	K126K	0.35
SKCM	chr11	123061142	Missense_Mutation	NA	M61I	0.19
SKCM	chr11	123057799	Missense_Mutation	NA	P626S	0.14
SKCM	chr11	123060123	Missense_Mutation	NA	D186A	0.37
SKCM	chr11	123060671	Silent	rs140536048	T111T	0.24
STAD	chr11	123059728	Missense_Mutation	NA	E289K	0.22
STAD	chr11	123058793	Missense_Mutation	NA	N454S	0.07
STAD	chr11	123057754	Missense_Mutation	novel	T641S	0.3
STAD	chr11	123057902	Silent	rs761588256	E591E	0.22
STAD	chr11	123060736	In_Frame_Del	novel	H89_W90delinsR	0.04
STAD	chr11	123059338	Intron	novel		0.45
STAD	chr11	123057668	3'UTR	novel		0.4
STAD	chr11	123061219	Missense_Mutation	NA	R36G	0.15
STAD	chr11	123060762	Missense_Mutation	NA	A81G	0.27
STAD	chr11	123058660	Missense_Mutation	novel	E498D	0.37
THCA	chr11	123061165	Missense_Mutation	NA	A54T	0.12
UCEC	chr11	123059901	Missense_Mutation	NA	E231A	0.34
UCEC	chr11	123059521	Nonsense_Mutation	NA	E358*	0.37
UCEC	chr11	123058292	Missense_Mutation	novel	D572G	0.27
UCEC	chr11	123059136	Missense_Mutation	NA	R416C	0.37
UCEC	chr11	123059945	Silent	NA	I216I	0.31
UCEC	chr11	123057702	3'UTR	novel		0.39
UCEC	chr11	123058802	Missense_Mutation	novel	K451T	0.08
UCEC	chr11	123061153	Nonsense_Mutation	novel	Q58*	0.33
UCEC	chr11	123059448	Intron	novel		0.06
UCEC	chr11	123059657	Silent	novel	G312G	0.39
UCEC	chr11	123060189	Missense_Mutation	novel	I164N	0.47
UCEC	chr11	123057764	Silent	NA	S637S	0.17
UCEC	chr11	123061150	Missense_Mutation	NA	V59I	0.18
UCEC	chr11	123060622	Missense_Mutation	NA	K128E	0.38
UCEC	chr11	123060727	Missense_Mutation	NA	M93V	0.45
UCEC	chr11	123058770	Missense_Mutation	rs746441724	T462A	0.51
UCEC	chr11	123057672	3'UTR	novel		0.27
UCEC	chr11	123059287	Intron	novel		0.33
UCEC	chr11	123061189	Missense_Mutation	novel	D46N	0.36
UCEC	chr11	123058457	Missense_Mutation	rs771746646	R517H	0.09
UCEC	chr11	123057852	Missense_Mutation	novel	T608I	0.33
UCEC	chr11	123058709	Missense_Mutation	NA	A482V	0.31
UCEC	chr11	123057672	3'UTR	novel		0.39
UCEC	chr11	123057617	3'UTR	novel		0.43
UCEC	chr11	123059508	Missense_Mutation	novel	S362I	0.43
UCEC	chr11	123058690	Silent	novel	V488V	0.37
UCEC	chr11	123060642	Missense_Mutation	novel	S121Y	0.44
UCEC	chr11	123061121	Missense_Mutation	novel	F68L	0.47
UCEC	chr11	123061123	Frame_Shift_Del	novel	*V67Lfs6**	0.46
UCEC	chr11	123059275	Intron	novel		0.29
UCEC	chr11	123057661	3'UTR	novel		0.39
UCEC	chr11	123058773	Missense_Mutation	novel	L461I	0.47
UCEC	chr11	123058279	Missense_Mutation	novel	E576D	0.11
UCEC	chr11	123058486	Splice_Site	novel	X508_splice	0.44
UCEC	chr11	123058266	Missense_Mutation	novel	L581F	0.38
UCEC	chr11	123059250	Missense_Mutation	novel	A378T	0.28
UCEC	chr11	123059569	Missense_Mutation	novel	R342C	0.23
UCEC	chr11	123060029	Splice_Site	novel	X189_splice	0.43
UCEC	chr11	123059118	Missense_Mutation	NA	T422A	0.32
UCEC	chr11	123059521	Nonsense_Mutation	NA	E358*	0.08
UCEC	chr11	123060727	Frame_Shift_Ins	novel	*M93Yfs5**	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.2843	0.00015732
CESC	DEL	0.5017	1.0762e-32
CHOL	DEL	0.3056	0.048655
ESCA	AMP	0.1033	0.018342
KIRP	DEL	0.0972	2.839e-05
LGG	AMP	0.1248	6.1002e-05
LIHC	DEL	0.2054	0.00030497
LUAD	DEL	0.1705	4.2393e-06
OV	DEL	0.2781	0.00073071
READ	DEL	0.1939	0.054114
SARC	DEL	0.4436	1.8105e-09
STAD	DEL	0.1565	8.3734e-05
TGCT	DEL	0.7733	0.21504
UCEC	DEL	0.1429	1.1558e-06
UCS	DEL	0.3929	0.086462
UVM	DEL	0.0875	0.023516

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00016	Kaplan-Meier Survival Analysis
BRCA	0.0011	Kaplan-Meier Survival Analysis
COAD	0.0013	Kaplan-Meier Survival Analysis
CESC	0.00022	Kaplan-Meier Survival Analysis
READ	0.033	Kaplan-Meier Survival Analysis
LAML	0.029	Kaplan-Meier Survival Analysis
KICH	0.023	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000109971 (Gene tree)
Gene ID: 3312
Gene Symbol: HSPA8
Alias: HSC71|HSC70|HSP73|HSPA10
Full Name: heat shock protein family A (Hsp70) member 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 5,742 bases
Position: chr11:123,057,489-123,063,230
Accession: 5241
RBP type: non-canonical RBP
Summary: This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26221025	Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner.	Biochem J	2015 Oct 1	Kakumani PK	doi: 10.1042/BJ20150445
22743058	Heat shock cognate 70 regulates the translocation and angiogenic function of nucleolin.	Arterioscler Thromb Vasc Biol	2012 Sep	Ding Y	doi: 10.1161/ATVBAHA.112.247502
11168378	Identification of tyrosine-phosphorylated proteins associated with the nuclear envelope.	Eur J Biochem	2001 Jan	Otto H	-
17218274	Cytokines direct the regulation of Bim mRNA stability by heat-shock cognate protein 70.	Mol Cell	2007 Jan 12	Matsui H	-
27596272	Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70.	Sci Rep	2016 Sep 6	Wang Y	doi: 10.1038/srep32832.
11599570	Characterization and regulation of the major histocompatibility complex-encoded proteins Hsp70-Hom and Hsp70-1/2.	Cell Stress Chaperones	2001 Jul	Fourie AM	-
11720291	Analysis of sequence-specific binding of RNA to Hsp70 and its various homologs indicates the involvement of N- and C-terminal interactions.	RNA	2001 Nov	Zimmer C	-
28855547	Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication.	Sci Rep	2017 Aug 30	Wang Y	doi: 10.1038/s41598-017-08815-z.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000526686	HSPA8-208	740	-	ENSP00000435019	150 (aa)	-	E9PM13
ENST00000532167	HSPA8-216	570	-	-	- (aa)	-	-
ENST00000524552	HSPA8-203	963	-	ENSP00000435908	223 (aa)	-	E9PS65
ENST00000526862	HSPA8-209	504	-	-	- (aa)	-	-
ENST00000527983	HSPA8-211	1509	-	-	- (aa)	-	-
ENST00000532636	HSPA8-218	2306	-	ENSP00000437125	646 (aa)	-	P11142
ENST00000534624	HSPA8-224	2463	-	ENSP00000432083	646 (aa)	-	P11142
ENST00000530391	HSPA8-213	648	-	ENSP00000434851	132 (aa)	-	E9PN25
ENST00000227378	HSPA8-201	2186	XM_011542798	ENSP00000227378	646 (aa)	XP_011541100	P11142
ENST00000532091	HSPA8-215	2301	-	-	- (aa)	-	-
ENST00000525463	HSPA8-205	583	-	ENSP00000436762	168 (aa)	-	E9PI65
ENST00000533238	HSPA8-220	465	-	-	- (aa)	-	-
ENST00000453788	HSPA8-202	2004	-	ENSP00000404372	493 (aa)	-	P11142
ENST00000532780	HSPA8-219	1194	-	-	- (aa)	-	-
ENST00000534319	HSPA8-222	1884	-	ENSP00000433316	410 (aa)	-	A8K7Q2
ENST00000526110	HSPA8-207	1924	-	ENSP00000433584	627 (aa)	-	E9PKE3
ENST00000525624	HSPA8-206	1048	-	ENSP00000435154	187 (aa)	-	E9PLF4
ENST00000532182	HSPA8-217	674	-	ENSP00000434415	171 (aa)	-	E9PQQ4
ENST00000534567	HSPA8-223	588	-	ENSP00000431641	183 (aa)	-	E9PK54
ENST00000531063	HSPA8-214	578	-	-	- (aa)	-	-
ENST00000524590	HSPA8-204	536	-	ENSP00000434565	137 (aa)	-	E9PPY6
ENST00000527387	HSPA8-210	579	-	ENSP00000436183	178 (aa)	-	E9PQK7
ENST00000528292	HSPA8-212	1112	-	ENSP00000432884	312 (aa)	-	E9PN89
ENST00000533540	HSPA8-221	1826	-	ENSP00000437189	500 (aa)	-	E9PNE6

Gene Model

Click here to download ENSG00000109971's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG
hsa04010	MAPK signaling pathway	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04144	Endocytosis	KEGG
hsa04213	Longevity regulating pathway - multiple species	KEGG
hsa04612	Antigen processing and presentation	KEGG
hsa04915	Estrogen signaling pathway	KEGG
hsa05134	Legionellosis	KEGG
hsa05145	Toxoplasmosis	KEGG
hsa05162	Measles	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000109971	Echocardiography	1.37074015971962E-5	17903301
ENSG00000109971	Echocardiography	8.19963834719263E-6	17903301
ENSG00000109971	Echocardiography	1.06965535430612E-5	17903301

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	EFO ID
ENSG00000109971	rs4936770	11	123058167	?	Time-dependent creatinine clearance change response to tenofovir treatment in HIV infection (time and treatment arm interaction)	26148204	EFO_0009279\|EFO_0000764\|EFO_0007934
ENSG00000109971	rs4802	11	123057914	?	Time-dependent creatinine clearance change response to tenofovir treatment in HIV infection (time and treatment arm interaction)	26148204	EFO_0009279\|EFO_0000764\|EFO_0007934
ENSG00000109971	rs4936770	11	123058167	?	Time-dependent creatinine clearance change response to tenofovir treatment in HIV infection (time and treatment arm interaction)	26148204	EFO_0009279\|EFO_0000764\|EFO_0007934
ENSG00000109971	rs2236659	11	123062473	?	Mean corpuscular hemoglobin	30595370	EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000109971's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000109971	HSPA8	100	100.000	ENSMUSG00000015656	Hspa8	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000151	ubiquitin ligase complex	12150907.	IDA	Component
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000974	Prp19 complex	20176811.	IDA	Component
GO:0001664	G protein-coupled receptor binding	12150907.	IPI	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	9305631.9499401.10722728.10954706.14532270.14557246.15047060.15657067.15708368.15936278.16169070.16189514.16275660.16293251.16531398.17022977.17400507.17620599.18457437.19338310.19800331.20195357.20391533.20618441.21148293.21150129.22085931.22365833.22645275.22990239.23431407.23455607.23523103.23801752.24122553.24136289.24189400.24318877.24510904.24658140.24787902.24947832.25416956.25609649.25719862.25760597.25910212.26212789.26871637.27103069.27708256.27916661.29568061.29601588.29764935.30021884.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	23921388.	IDA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005615	extracellular space	16502470.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	20176811.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	-	IEA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005764	lysosome	21873635.	IBA	Component
GO:0005765	lysosomal membrane	-	ISS	Component
GO:0005776	autophagosome	21873635.	IBA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	21231916.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006457	protein folding	8530083.	NAS	Process
GO:0006986	response to unfolded protein	21873635.	IBA	Process
GO:0006986	response to unfolded protein	11093761.	NAS	Process
GO:0007269	neurotransmitter secretion	-	TAS	Process
GO:0008088	axo-dendritic transport	21873635.	IBA	Process
GO:0009267	cellular response to starvation	20176123.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0016192	vesicle-mediated transport	21873635.	IBA	Process
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0016887	ATPase activity	23921388.	IDA	Function
GO:0016887	ATPase activity	-	TAS	Function
GO:0019221	cytokine-mediated signaling pathway	-	TAS	Process
GO:0019899	enzyme binding	23921388.	IPI	Function
GO:0023026	MHC class II protein complex binding	20458337.	HDA	Function
GO:0030424	axon	21873635.	IBA	Component
GO:0030425	dendrite	21873635.	IBA	Component
GO:0030674	protein binding, bridging	16207813.	IPI	Function
GO:0031072	heat shock protein binding	21873635.	IBA	Function
GO:0031072	heat shock protein binding	17182002.23921388.	IPI	Function
GO:0031625	ubiquitin protein ligase binding	12150907.16207813.	IPI	Function
GO:0031647	regulation of protein stability	26212789.	IMP	Process
GO:0034605	cellular response to heat	21873635.	IBA	Process
GO:0034620	cellular response to unfolded protein	21873635.	IBA	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0042026	protein refolding	21873635.	IBA	Process
GO:0042026	protein refolding	21231916.25719862.	IDA	Process
GO:0042470	melanosome	-	IEA	Component
GO:0042623	ATPase activity, coupled	21873635.	IBA	Function
GO:0042623	ATPase activity, coupled	8530083.	NAS	Function
GO:0042623	ATPase activity, coupled	-	TAS	Function
GO:0043195	terminal bouton	21873635.	IBA	Component
GO:0043202	lysosomal lumen	25719862.	TAS	Component
GO:0043254	regulation of protein complex assembly	20176123.	TAS	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0044183	protein binding involved in protein folding	21873635.	IBA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045892	negative regulation of transcription, DNA-templated	10722728.	IDA	Process
GO:0046034	ATP metabolic process	23921388.	IDA	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0051082	unfolded protein binding	21231916.	IDA	Function
GO:0051085	chaperone cofactor-dependent protein refolding	21873635.	IBA	Process
GO:0051087	chaperone binding	16207813.	IPI	Function
GO:0051787	misfolded protein binding	21873635.	IBA	Function
GO:0055131	C3HC4-type RING finger domain binding	25281747.	IPI	Function
GO:0061024	membrane organization	-	TAS	Process
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	-	TAS	Component
GO:0061635	regulation of protein complex stability	-	ISS	Process
GO:0061684	chaperone-mediated autophagy	-	ISS	Process
GO:0061684	chaperone-mediated autophagy	20176123.25719862.	TAS	Process
GO:0061738	late endosomal microautophagy	21873635.	IBA	Process
GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	21873635.	IBA	Process
GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	26212789.	IMP	Process
GO:0061740	protein targeting to lysosome involved in chaperone-mediated autophagy	2799391.	TAS	Process
GO:0061741	chaperone-mediated protein transport involved in chaperone-mediated autophagy	21873635.	IBA	Process
GO:0061741	chaperone-mediated protein transport involved in chaperone-mediated autophagy	25719862.	NAS	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.21362503.23533145.	HDA	Component
GO:0070062	extracellular exosome	19028452.21235781.	IDA	Component
GO:0072318	clathrin coat disassembly	-	IEA	Process
GO:0072562	blood microparticle	22516433.	HDA	Component
GO:0098575	lumenal side of lysosomal membrane	20176123.	TAS	Component
GO:0099523	presynaptic cytosol	21873635.	IBA	Component
GO:0099524	postsynaptic cytosol	21873635.	IBA	Component
GO:0101031	chaperone complex	16207813.	IPI	Component
GO:1900034	regulation of cellular response to heat	-	TAS	Process
GO:1902904	negative regulation of supramolecular fiber organization	23921388.	IDA	Process
GO:1904589	regulation of protein import	20176123.	TAS	Process
GO:1904764	chaperone-mediated autophagy translocation complex disassembly	21873635.	IBA	Process
GO:1904764	chaperone-mediated autophagy translocation complex disassembly	-	ISS	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component
GO:1990832	slow axonal transport	21873635.	IBA	Process
GO:1990833	clathrin-uncoating ATPase activity	21873635.	IBA	Function
GO:1990904	ribonucleoprotein complex	17289661.	IDA	Component

EuRBPDB

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Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

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