EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
12421917Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells.J Immunol2002 Nov 15Noessner E-
18772114Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.Cancer Cell2008 Sep 9Powers MVdoi: 10.1016/j.ccr.2008.08.002.
26229111Characterization of Aes nuclear foci in colorectal cancer cells.J Biochem2016 JanItatani Ydoi: 10.1093/jb/mvv077
23065205HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case-control study.Mol Biol Rep2012 DecZagouri Fdoi: 10.1007/s11033-012-1984-2
24327656The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.J Biol Chem2014 Jan 31Connarn JNdoi: 10.1074/jbc.M113.519421
24736948Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-specic apoptosis.Int J Oncol2014 JulWang Hdoi: 10.3892/ijo.2014.2388
19802014Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells.Oncogene2010 Jan 7Nird?? Pdoi: 10.1038/onc.2009.311
15336565Expression of methionine aminopeptidase 2, N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29.Biochem Biophys Res Commun2004 Sep 24Selvakumar P-

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr11123058681SilentnovelV491V0.46
ACCchr11123058683Missense_MutationnovelV491L0.46
BLCAchr11123059941Missense_MutationnovelE218Q0.18
BLCAchr11123061175SilentNAL50L0.3
BLCAchr11123060300Intronnovel0.16
BLCAchr11123059663SilentnovelF310F0.37
BLCAchr11123059830Nonsense_MutationnovelE255*0.1
BLCAchr11123061226SilentnovelQ33Q0.48
BLCAchr11123057779SilentNAP632P0.16
BLCAchr11123057749SilentnovelI642I0.34
BLCAchr11123059639Missense_MutationnovelE318D0.84
BLCAchr11123057745Missense_MutationNAE644K0.21
BLCAchr11123058694Missense_Mutationrs749707173N487S0.15
BLCAchr11123057778Frame_Shift_InsnovelS633Lfs*110.42
BLCAchr11123058827Missense_MutationNAY443H0.34
BLCAchr11123058425Missense_MutationnovelE528K0.47
BLCAchr11123059830Missense_MutationnovelE255K0.56
BLCAchr11123060019Missense_MutationNAE192Q0.51
BLCAchr11123058709Missense_MutationNAA482V0.43
BRCAchr11123058762Missense_MutationNAI464M0.41
BRCAchr11123059897Missense_MutationNAD232E0.13
BRCAchr11123058735Missense_MutationnovelQ473H0.57
BRCAchr11123061254Missense_MutationNAG24E0.21
BRCAchr11123058771SilentNAL461L0.76
BRCAchr11123059586In_Frame_DelNAL336del0.35
BRCAchr11123061117Splice_Regionnovel0.46
BRCAchr11123061153Missense_MutationnovelQ58E0.19
CESCchr11123058281Missense_MutationnovelE576K0.32
CESCchr11123058312Missense_MutationNAE565D0.5
CESCchr11123058263Missense_MutationNAD582N0.17
CESCchr11123057739Missense_MutationNAD646H0.15
CESCchr11123061213Missense_MutationnovelT38A0.41
CESCchr11123059143SilentnovelL413L0.19
CESCchr11123060743Missense_MutationNAM87I0.48
CESCchr11123060785SilentNAL73L0.19
CESCchr11123061294Missense_MutationnovelL11F0.28
CHOLchr11123061239Missense_MutationnovelI29S0.65
COADchr11123059290Intronnovel0.37
COADchr11123058377Missense_MutationnovelS544P0.22
COADchr11123059984SilentnovelG203G0.49
COADchr11123060734Nonsense_MutationnovelW90*0.16
COADchr11123058337Missense_MutationNAK557T0.31
COADchr11123059741Silentrs148846437I284I0.25
COADchr11123059135Missense_MutationNAR416H0.38
COADchr11123058302Frame_Shift_DelNAK569Dfs*60.3
COADchr11123058279Missense_MutationnovelE576D0.28
COADchr11123057734Nonstop_Mutationnovel*647Yext*50.24
COADchr11123057810In_Frame_DelnovelM621_G624del0.28
ESCAchr11123057892Missense_MutationnovelQ595E0.35
ESCAchr11123057792Missense_MutationnovelG628D0.07
GBMchr11123060355Intronnovel0.25
HNSCchr11123059939SilentnovelE218E0.14
HNSCchr11123057757Missense_MutationnovelP640S0.71
HNSCchr11123058832Splice_Regionnovel0.16
HNSCchr11123060676Missense_MutationnovelE110Q0.09
HNSCchr11123057885Missense_MutationnovelK597I0.35
HNSCchr11123058746Frame_Shift_InsnovelG470Rfs*60.07
HNSCchr11123058748Missense_MutationnovelR469P0.13
HNSCchr11123060198Missense_MutationnovelA161D0.16
HNSCchr11123059662Missense_MutationnovelR311C0.31
HNSCchr11123059677Missense_MutationnovelN306D0.21
HNSCchr11123057816In_Frame_Delrs765426437M621_G624del0.17
HNSCchr11123059657SilentnovelG312G0.33
KICHchr11123060695Silentrs751477695V103V0.04
KIRCchr11123059568Missense_MutationNAR342P0.14
KIRCchr11123059554Nonsense_MutationNAQ347*0.32
KIRCchr11123059556Missense_MutationNAI346N0.34
KIRCchr11123061289Silentrs536070549G12G0.23
KIRCchr11123061267Missense_MutationNAV20L0.26
KIRCchr11123060190Missense_MutationNAI164V0.4
KIRCchr11123060264Frame_Shift_InsnovelV139Gfs*500.11
KIRCchr11123059960Silentrs756568266T211T0.3
KIRCchr11123061133SilentNAT64T0.28
KIRCchr11123060221SilentNAS153S0.42
KIRCchr11123058697Missense_MutationNAL486P0.21
KIRCchr11123060293Intronnovel0.38
KIRPchr11123060254SilentnovelA142A0.54
KIRPchr11123059056Splice_Regionnovel0.12
KIRPchr11123060232Missense_MutationNAF150L0.44
KIRPchr11123061269Missense_MutationnovelG19A0.57
KIRPchr11123058670In_Frame_InsnovelK493_S494dup0.11
LAMLchr11123060096Intronnovel0.1
LAMLchr11123060600Missense_MutationnovelL135R0.09
LGGchr11123057790Missense_MutationNAG629R0.34
LIHCchr11123059117Missense_MutationnovelT422N0.3
LIHCchr11123061139SilentNAN62N0.14
LIHCchr11123059514Missense_Mutationrs756920138N360S0.09
LUADchr11123059683Missense_MutationNAE304K0.2
LUADchr11123060205Missense_MutationNAK159E0.27
LUADchr11123057820Frame_Shift_InsnovelG619Rfs*250.47
LUADchr11123058656Nonsense_MutationnovelK500*0.46
LUADchr11123060652Nonsense_MutationNAE118*0.19
LUADchr11123060116Splice_RegionNAK188K0.08
LUADchr111230576083'UTRnovel0.43
LUADchr11123061249Missense_MutationnovelV26I0.12
LUADchr11123059998Missense_MutationnovelD199Y0.28
LUADchr11123060676Missense_MutationnovelE110K0.12
LUADchr11123061254Missense_MutationNAG24E0.09
LUADchr11123059985Missense_MutationNAG203D0.29
LUADchr11123061180Missense_MutationNAR49W0.47
LUADchr11123058807Missense_MutationnovelM449I0.07
LUADchr11123059998Missense_MutationnovelD199N0.12
LUSCchr11123058411Missense_MutationnovelQ532H0.16
LUSCchr11123059952Missense_MutationnovelD214G0.1
LUSCchr11123058660SilentnovelE498E0.06
LUSCchr11123058258Frame_Shift_InsnovelN584Efs*50.33
LUSCchr11123058391Missense_MutationnovelK539M0.37
LUSCchr11123058750SilentNAP468P0.13
LUSCchr11123058267Missense_MutationNAW580C0.29
LUSCchr11123060121Missense_MutationnovelK187E0.09
LUSCchr11123060328Intronnovel0.19
LUSCchr11123058823Missense_MutationnovelE444V0.1
OVchr11123060135Frame_Shift_InsnovelA182Vfs*180.31
OVchr11123060136Frame_Shift_InsnovelA182Pfs*140.3
OVchr11123059460Intronnovel0.11
OVchr11123059585Frame_Shift_DelNAD333Gfs*250.46
OVchr11123059912SilentnovelH227H0.12
PAADchr11123059680Missense_MutationnovelL305M0.16
PAADchr11123060786Missense_MutationnovelL73P0.21
PRADchr11123060261Missense_Mutationrs141156763T140N0.09
PRADchr11123058694Missense_Mutationrs749707173N487S0.12
PRADchr11123060640Missense_MutationnovelM122V0.15
PRADchr11123058705Missense_MutationNAN483K0.32
PRADchr11123059792Missense_MutationnovelC267W0.16
PRADchr11123058278Missense_MutationNAI577V0.33
PRADchr11123059502Missense_MutationnovelN364S0.1
READchr11123059550Missense_MutationNAK348T0.32
READchr11123058460Missense_MutationNAE516G0.07
READchr11123059658Missense_MutationNAG312A0.39
READchr11123060292Intronnovel0.39
READchr11123061123Missense_MutationNAF68I0.44
SARCchr111230576893'UTRnovel0.19
SKCMchr11123057799Missense_MutationNAP626S0.22
SKCMchr11123058324SilentNAK561K0.09
SKCMchr11123058271Missense_MutationnovelN579S0.85
SKCMchr11123059356Intronnovel0.78
SKCMchr11123061157SilentnovelK56K0.51
SKCMchr111230576723'UTRnovel0.25
SKCMchr11123061142Missense_MutationNAM61I0.78
SKCMchr11123060626Silentrs374961418K126K0.35
SKCMchr11123061142Missense_MutationNAM61I0.19
SKCMchr11123057799Missense_MutationNAP626S0.14
SKCMchr11123060123Missense_MutationNAD186A0.37
SKCMchr11123060671Silentrs140536048T111T0.24
STADchr11123059728Missense_MutationNAE289K0.22
STADchr11123058793Missense_MutationNAN454S0.07
STADchr11123057754Missense_MutationnovelT641S0.3
STADchr11123057902Silentrs761588256E591E0.22
STADchr11123060736In_Frame_DelnovelH89_W90delinsR0.04
STADchr11123059338Intronnovel0.45
STADchr111230576683'UTRnovel0.4
STADchr11123061219Missense_MutationNAR36G0.15
STADchr11123060762Missense_MutationNAA81G0.27
STADchr11123058660Missense_MutationnovelE498D0.37
THCAchr11123061165Missense_MutationNAA54T0.12
UCECchr11123059901Missense_MutationNAE231A0.34
UCECchr11123059521Nonsense_MutationNAE358*0.37
UCECchr11123058292Missense_MutationnovelD572G0.27
UCECchr11123059136Missense_MutationNAR416C0.37
UCECchr11123059945SilentNAI216I0.31
UCECchr111230577023'UTRnovel0.39
UCECchr11123058802Missense_MutationnovelK451T0.08
UCECchr11123061153Nonsense_MutationnovelQ58*0.33
UCECchr11123059448Intronnovel0.06
UCECchr11123059657SilentnovelG312G0.39
UCECchr11123060189Missense_MutationnovelI164N0.47
UCECchr11123057764SilentNAS637S0.17
UCECchr11123061150Missense_MutationNAV59I0.18
UCECchr11123060622Missense_MutationNAK128E0.38
UCECchr11123060727Missense_MutationNAM93V0.45
UCECchr11123058770Missense_Mutationrs746441724T462A0.51
UCECchr111230576723'UTRnovel0.27
UCECchr11123059287Intronnovel0.33
UCECchr11123061189Missense_MutationnovelD46N0.36
UCECchr11123058457Missense_Mutationrs771746646R517H0.09
UCECchr11123057852Missense_MutationnovelT608I0.33
UCECchr11123058709Missense_MutationNAA482V0.31
UCECchr111230576723'UTRnovel0.39
UCECchr111230576173'UTRnovel0.43
UCECchr11123059508Missense_MutationnovelS362I0.43
UCECchr11123058690SilentnovelV488V0.37
UCECchr11123060642Missense_MutationnovelS121Y0.44
UCECchr11123061121Missense_MutationnovelF68L0.47
UCECchr11123061123Frame_Shift_DelnovelV67Lfs*60.46
UCECchr11123059275Intronnovel0.29
UCECchr111230576613'UTRnovel0.39
UCECchr11123058773Missense_MutationnovelL461I0.47
UCECchr11123058279Missense_MutationnovelE576D0.11
UCECchr11123058486Splice_SitenovelX508_splice0.44
UCECchr11123058266Missense_MutationnovelL581F0.38
UCECchr11123059250Missense_MutationnovelA378T0.28
UCECchr11123059569Missense_MutationnovelR342C0.23
UCECchr11123060029Splice_SitenovelX189_splice0.43
UCECchr11123059118Missense_MutationNAT422A0.32
UCECchr11123059521Nonsense_MutationNAE358*0.08
UCECchr11123060727Frame_Shift_InsnovelM93Yfs*50.44

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.28430.00015732
CESCDEL0.50171.0762e-32
CHOLDEL0.30560.048655
ESCAAMP0.10330.018342
KIRPDEL0.09722.839e-05
LGGAMP0.12486.1002e-05
LIHCDEL0.20540.00030497
LUADDEL0.17054.2393e-06
OVDEL0.27810.00073071
READDEL0.19390.054114
SARCDEL0.44361.8105e-09
STADDEL0.15658.3734e-05
TGCTDEL0.77330.21504
UCECDEL0.14291.1558e-06
UCSDEL0.39290.086462
UVMDEL0.08750.023516

Survival Analysis
CancerP-value Q-value
KIRC0.00016

Kaplan-Meier Survival Analysis

BRCA0.0011

Kaplan-Meier Survival Analysis

COAD0.0013

Kaplan-Meier Survival Analysis

CESC0.00022

Kaplan-Meier Survival Analysis

READ0.033

Kaplan-Meier Survival Analysis

LAML0.029

Kaplan-Meier Survival Analysis

KICH0.023

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000109971 (Gene tree)
Gene ID
3312
Gene Symbol
HSPA8
Alias
HSC71|HSC70|HSP73|HSPA10
Full Name
heat shock protein family A (Hsp70) member 8
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
5,742 bases
Position
chr11:123,057,489-123,063,230
Accession
5241
RBP type
non-canonical RBP
Summary
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
26221025Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner.Biochem J2015 Oct 1Kakumani PKdoi: 10.1042/BJ20150445
22743058Heat shock cognate 70 regulates the translocation and angiogenic function of nucleolin.Arterioscler Thromb Vasc Biol2012 SepDing Ydoi: 10.1161/ATVBAHA.112.247502
11168378Identification of tyrosine-phosphorylated proteins associated with the nuclear envelope.Eur J Biochem2001 JanOtto H-
17218274Cytokines direct the regulation of Bim mRNA stability by heat-shock cognate protein 70.Mol Cell2007 Jan 12Matsui H-
27596272Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70.Sci Rep2016 Sep 6Wang Ydoi: 10.1038/srep32832.
11599570Characterization and regulation of the major histocompatibility complex-encoded proteins Hsp70-Hom and Hsp70-1/2.Cell Stress Chaperones2001 JulFourie AM-
11720291Analysis of sequence-specific binding of RNA to Hsp70 and its various homologs indicates the involvement of N- and C-terminal interactions.RNA2001 NovZimmer C-
28855547Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication.Sci Rep2017 Aug 30Wang Ydoi: 10.1038/s41598-017-08815-z.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000526686HSPA8-208740-ENSP00000435019150 (aa)-E9PM13
ENST00000532167HSPA8-216570--- (aa)--
ENST00000524552HSPA8-203963-ENSP00000435908223 (aa)-E9PS65
ENST00000526862HSPA8-209504--- (aa)--
ENST00000527983HSPA8-2111509--- (aa)--
ENST00000532636HSPA8-2182306-ENSP00000437125646 (aa)-P11142
ENST00000534624HSPA8-2242463-ENSP00000432083646 (aa)-P11142
ENST00000530391HSPA8-213648-ENSP00000434851132 (aa)-E9PN25
ENST00000227378HSPA8-2012186XM_011542798ENSP00000227378646 (aa)XP_011541100P11142
ENST00000532091HSPA8-2152301--- (aa)--
ENST00000525463HSPA8-205583-ENSP00000436762168 (aa)-E9PI65
ENST00000533238HSPA8-220465--- (aa)--
ENST00000453788HSPA8-2022004-ENSP00000404372493 (aa)-P11142
ENST00000532780HSPA8-2191194--- (aa)--
ENST00000534319HSPA8-2221884-ENSP00000433316410 (aa)-A8K7Q2
ENST00000526110HSPA8-2071924-ENSP00000433584627 (aa)-E9PKE3
ENST00000525624HSPA8-2061048-ENSP00000435154187 (aa)-E9PLF4
ENST00000532182HSPA8-217674-ENSP00000434415171 (aa)-E9PQQ4
ENST00000534567HSPA8-223588-ENSP00000431641183 (aa)-E9PK54
ENST00000531063HSPA8-214578--- (aa)--
ENST00000524590HSPA8-204536-ENSP00000434565137 (aa)-E9PPY6
ENST00000527387HSPA8-210579-ENSP00000436183178 (aa)-E9PQK7
ENST00000528292HSPA8-2121112-ENSP00000432884312 (aa)-E9PN89
ENST00000533540HSPA8-2211826-ENSP00000437189500 (aa)-E9PNE6
Gene Model
Click here to download ENSG00000109971's gene model file
Pathways
Pathway IDPathway NameSource
hsa03040SpliceosomeKEGG
hsa04010MAPK signaling pathwayKEGG
hsa04141Protein processing in endoplasmic reticulumKEGG
hsa04144EndocytosisKEGG
hsa04213Longevity regulating pathway - multiple speciesKEGG
hsa04612Antigen processing and presentationKEGG
hsa04915Estrogen signaling pathwayKEGG
hsa05134LegionellosisKEGG
hsa05145ToxoplasmosisKEGG
hsa05162MeaslesKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000109971Echocardiography1.37074015971962E-517903301
ENSG00000109971Echocardiography8.19963834719263E-617903301
ENSG00000109971Echocardiography1.06965535430612E-517903301
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000109971rs493677011123058167?Time-dependent creatinine clearance change response to tenofovir treatment in HIV infection (time and treatment arm interaction)26148204EFO_0009279|EFO_0000764|EFO_0007934
ENSG00000109971rs480211123057914?Time-dependent creatinine clearance change response to tenofovir treatment in HIV infection (time and treatment arm interaction)26148204EFO_0009279|EFO_0000764|EFO_0007934
ENSG00000109971rs493677011123058167?Time-dependent creatinine clearance change response to tenofovir treatment in HIV infection (time and treatment arm interaction)26148204EFO_0009279|EFO_0000764|EFO_0007934
ENSG00000109971rs223665911123062473?Mean corpuscular hemoglobin30595370EFO_0004527
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000109971's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000109971HSPA8100100.000ENSMUSG00000015656Hspa8100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000151ubiquitin ligase complex12150907.IDAComponent
GO:0000398mRNA splicing, via spliceosome-TASProcess
GO:0000974Prp19 complex20176811.IDAComponent
GO:0001664G protein-coupled receptor binding12150907.IPIFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding9305631.9499401.10722728.10954706.14532270.14557246.15047060.15657067.15708368.15936278.16169070.16189514.16275660.16293251.16531398.17022977.17400507.17620599.18457437.19338310.19800331.20195357.20391533.20618441.21148293.21150129.22085931.22365833.22645275.22990239.23431407.23455607.23523103.23801752.24122553.24136289.24189400.24318877.24510904.24658140.24787902.24947832.25416956.25609649.25719862.25760597.25910212.26212789.26871637.27103069.27708256.27916661.29568061.29601588.29764935.30021884.IPIFunction
GO:0005524ATP binding21873635.IBAFunction
GO:0005524ATP binding23921388.IDAFunction
GO:0005576extracellular region-TASComponent
GO:0005615extracellular space16502470.HDAComponent
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus20176811.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005681spliceosomal complex-IEAComponent
GO:0005730nucleolus-IEAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005764lysosome21873635.IBAComponent
GO:0005765lysosomal membrane-ISSComponent
GO:0005776autophagosome21873635.IBAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol21231916.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006457protein folding8530083.NASProcess
GO:0006986response to unfolded protein21873635.IBAProcess
GO:0006986response to unfolded protein11093761.NASProcess
GO:0007269neurotransmitter secretion-TASProcess
GO:0008088axo-dendritic transport21873635.IBAProcess
GO:0009267cellular response to starvation20176123.TASProcess
GO:0016020membrane19946888.HDAComponent
GO:0016032viral process-IEAProcess
GO:0016192vesicle-mediated transport21873635.IBAProcess
GO:0016887ATPase activity21873635.IBAFunction
GO:0016887ATPase activity23921388.IDAFunction
GO:0016887ATPase activity-TASFunction
GO:0019221cytokine-mediated signaling pathway-TASProcess
GO:0019899enzyme binding23921388.IPIFunction
GO:0023026MHC class II protein complex binding20458337.HDAFunction
GO:0030424axon21873635.IBAComponent
GO:0030425dendrite21873635.IBAComponent
GO:0030674protein binding, bridging16207813.IPIFunction
GO:0031072heat shock protein binding21873635.IBAFunction
GO:0031072heat shock protein binding17182002.23921388.IPIFunction
GO:0031625ubiquitin protein ligase binding12150907.16207813.IPIFunction
GO:0031647regulation of protein stability26212789.IMPProcess
GO:0034605cellular response to heat21873635.IBAProcess
GO:0034620cellular response to unfolded protein21873635.IBAProcess
GO:0034774secretory granule lumen-TASComponent
GO:0042026protein refolding21873635.IBAProcess
GO:0042026protein refolding21231916.25719862.IDAProcess
GO:0042470melanosome-IEAComponent
GO:0042623ATPase activity, coupled21873635.IBAFunction
GO:0042623ATPase activity, coupled8530083.NASFunction
GO:0042623ATPase activity, coupled-TASFunction
GO:0043195terminal bouton21873635.IBAComponent
GO:0043202lysosomal lumen25719862.TASComponent
GO:0043254regulation of protein complex assembly20176123.TASProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0043488regulation of mRNA stability-TASProcess
GO:0044183protein binding involved in protein folding21873635.IBAFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0045892negative regulation of transcription, DNA-templated10722728.IDAProcess
GO:0046034ATP metabolic process23921388.IDAProcess
GO:0051082unfolded protein binding21873635.IBAFunction
GO:0051082unfolded protein binding21231916.IDAFunction
GO:0051085chaperone cofactor-dependent protein refolding21873635.IBAProcess
GO:0051087chaperone binding16207813.IPIFunction
GO:0051787misfolded protein binding21873635.IBAFunction
GO:0055131C3HC4-type RING finger domain binding25281747.IPIFunction
GO:0061024membrane organization-TASProcess
GO:0061202clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane-TASComponent
GO:0061635regulation of protein complex stability-ISSProcess
GO:0061684chaperone-mediated autophagy-ISSProcess
GO:0061684chaperone-mediated autophagy20176123.25719862.TASProcess
GO:0061738late endosomal microautophagy21873635.IBAProcess
GO:0061740protein targeting to lysosome involved in chaperone-mediated autophagy21873635.IBAProcess
GO:0061740protein targeting to lysosome involved in chaperone-mediated autophagy26212789.IMPProcess
GO:0061740protein targeting to lysosome involved in chaperone-mediated autophagy2799391.TASProcess
GO:0061741chaperone-mediated protein transport involved in chaperone-mediated autophagy21873635.IBAProcess
GO:0061741chaperone-mediated protein transport involved in chaperone-mediated autophagy25719862.NASProcess
GO:0070062extracellular exosome19056867.19199708.20458337.21362503.23533145.HDAComponent
GO:0070062extracellular exosome19028452.21235781.IDAComponent
GO:0072318clathrin coat disassembly-IEAProcess
GO:0072562blood microparticle22516433.HDAComponent
GO:0098575lumenal side of lysosomal membrane20176123.TASComponent
GO:0099523presynaptic cytosol21873635.IBAComponent
GO:0099524postsynaptic cytosol21873635.IBAComponent
GO:0101031chaperone complex16207813.IPIComponent
GO:1900034regulation of cellular response to heat-TASProcess
GO:1902904negative regulation of supramolecular fiber organization23921388.IDAProcess
GO:1904589regulation of protein import20176123.TASProcess
GO:1904764chaperone-mediated autophagy translocation complex disassembly21873635.IBAProcess
GO:1904764chaperone-mediated autophagy translocation complex disassembly-ISSProcess
GO:1904813ficolin-1-rich granule lumen-TASComponent
GO:1990832slow axonal transport21873635.IBAProcess
GO:1990833clathrin-uncoating ATPase activity21873635.IBAFunction
GO:1990904ribonucleoprotein complex17289661.IDAComponent
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