EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25311765	ATP5b and β2-microglobulin are predictive markers for the prognosis of patients with gallbladder cancer.	J Mol Histol	2015 Feb	Sun J	doi: 10.1007/s10735-014-9597-9
28259978	Ectopic expression of the ATP synthase β subunit on the membrane of PC-3M cells supports its potential role in prostate cancer metastasis.	Int J Oncol	2017 Apr	Li W	doi: 10.3892/ijo.2017.3878
24583174	Investigation of the association between ATP2B4 and ATP5B genes with colorectal cancer.	Gene	2014 May 1	Geyik E	doi: 10.1016/j.gene.2014.02.050
20663914	Human G3BP1 interacts with beta-F1-ATPase mRNA and inhibits its translation.	J Cell Sci	2010 Aug 15	Ortega AD	doi: 10.1242/jcs.065920
28347227	Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells.	Tumour Biol	2017 Mar	Cai Q	doi: 10.1177/1010428317695015.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr12	56645038	Intron	novel		0.28
BLCA	chr12	56638251	3'UTR	novel		0.12
BLCA	chr12	56643861	Missense_Mutation	novel	P195S	0.17
BLCA	chr12	56642675	Missense_Mutation	novel	E317Q	0.24
BLCA	chr12	56640110	Missense_Mutation	rs747376704	S386L	0.31
BLCA	chr12	56645876	Missense_Mutation	NA	Q30E	0.22
BLCA	chr12	56643883	Silent	NA	I187I	0.23
BRCA	chr12	56638295	3'UTR	novel		0.16
BRCA	chr12	56642502	Missense_Mutation	NA	E344Q	0.12
BRCA	chr12	56646030	5'UTR	novel		0.26
BRCA	chr12	56644806	Missense_Mutation	novel	E154K	0.11
CESC	chr12	56643473	Frame_Shift_Ins	novel	*R241Lfs2**	0.08
CESC	chr12	56639312	Splice_Region	rs774942479		0.33
CESC	chr12	56645961	Translation_Start_Site	novel	M1?	0.24
CESC	chr12	56645890	Missense_Mutation	rs2293450	S25L	0.3
CESC	chr12	56645985	5'UTR	novel		0.39
COAD	chr12	56645028	Intron	novel		0.09
COAD	chr12	56645183	Missense_Mutation	novel	A100T	0.38
COAD	chr12	56643526	Silent	rs761151482	V223V	0.15
COAD	chr12	56642467	Silent	NA	T355T	0.33
COAD	chr12	56639235	Missense_Mutation	novel	V454M	0.08
COAD	chr12	56640115	Silent	NA	V384V	0.35
COAD	chr12	56642540	Missense_Mutation	NA	Y331C	0.41
COAD	chr12	56642564	Missense_Mutation	NA	G323D	0.24
COAD	chr12	56640143	Missense_Mutation	NA	T375M	0.23
COAD	chr12	56645877	Silent	novel	A29A	0.06
COAD	chr12	56644873	Frame_Shift_Del	novel	*A130Dfs8**	0.06
COAD	chr12	56645975	5'UTR	novel		0.5
ESCA	chr12	56643429	Missense_Mutation	novel	I256F	0.26
ESCA	chr12	56646030	5'UTR	novel		0.29
GBM	chr12	56644785	Nonsense_Mutation	novel	K161*	0.07
GBM	chr12	56639155	Missense_Mutation	novel	K480N	0.11
GBM	chr12	56640110	Missense_Mutation	rs747376704	S386L	0.15
GBM	chr12	56643936	Missense_Mutation	novel	A170T	0.04
HNSC	chr12	56640110	Missense_Mutation	rs747376704	S386L	0.24
KIRC	chr12	56643459	Silent	NA	L246L	0.31
KIRC	chr12	56640173	Missense_Mutation	NA	D365G	0.17
KIRC	chr12	56642457	Splice_Site	NA	X358_splice	0.29
KIRP	chr12	56639989	Missense_Mutation	novel	K426N	0.36
LGG	chr12	56645092	Intron	novel		0.29
LGG	chr12	56643587	Missense_Mutation	novel	G203E	0.37
LGG	chr12	56642688	Silent	NA	T312T	0.28
LGG	chr12	56645309	Missense_Mutation	novel	A58T	0.29
LIHC	chr12	56638215	3'UTR	novel		0.44
LIHC	chr12	56643923	Missense_Mutation	novel	M174T	0.33
LIHC	chr12	56638361	Missense_Mutation	NA	A518T	0.38
LIHC	chr12	56643900	Missense_Mutation	NA	I182V	0.19
LIHC	chr12	56644866	Missense_Mutation	rs11542649	I134V	0.32
LUAD	chr12	56639276	Missense_Mutation	NA	I440S	0.1
LUAD	chr12	56639199	Missense_Mutation	NA	Q466E	0.09
LUAD	chr12	56642739	Silent	NA	D295D	0.11
LUAD	chr12	56640004	Silent	NA	A421A	0.18
LUAD	chr12	56643441	Missense_Mutation	NA	E252K	0.28
LUAD	chr12	56645286	Silent	novel	A65A	0.26
LUSC	chr12	56638228	3'UTR	novel		0.38
LUSC	chr12	56645920	Missense_Mutation	novel	G15V	0.29
LUSC	chr12	56638249	3'UTR	novel		0.2
LUSC	chr12	56638409	Missense_Mutation	novel	L502V	0.09
LUSC	chr12	56645350	Missense_Mutation	novel	R44K	0.12
LUSC	chr12	56639141	Missense_Mutation	novel	K485M	0.21
LUSC	chr12	56643873	Missense_Mutation	novel	D191N	0.23
LUSC	chr12	56645911	Missense_Mutation	novel	R18Q	0.42
OV	chr12	56645184	Silent	NA	V99V	0.24
OV	chr12	56645255	Frame_Shift_Ins	novel	*D76Ffs5**	0.07
OV	chr12	56640191	Missense_Mutation	novel	A359V	0.13
PAAD	chr12	56639165	Missense_Mutation	novel	H477R	0.18
READ	chr12	56645260	Missense_Mutation	novel	Q74P	0.53
SARC	chr12	56639297	Missense_Mutation	novel	S433F	0.37
SKCM	chr12	56640142	Silent	rs368274816	T375T	0.1
SKCM	chr12	56646030	5'UTR	novel		0.23
SKCM	chr12	56638392	Silent	rs779979814	F507F	0.36
SKCM	chr12	56639145	Silent	NA	L484L	0.39
SKCM	chr12	56645068	Intron	novel		0.22
SKCM	chr12	56642745	Silent	novel	F293F	0.63
SKCM	chr12	56643454	Silent	NA	Y247Y	0.52
STAD	chr12	56643423	Missense_Mutation	NA	L258V	0.13
STAD	chr12	56644822	Silent	NA	I148I	0.28
STAD	chr12	56639210	Missense_Mutation	rs766490903	R462H	0.42
STAD	chr12	56640037	Silent	NA	P410P	0.36
STAD	chr12	56642671	Splice_Site	novel	X317_splice	0.13
STAD	chr12	56642739	Silent	NA	D295D	0.25
STAD	chr12	56642695	Missense_Mutation	NA	R310H	0.42
STAD	chr12	56642826	Silent	rs768985218	A266A	0.12
STAD	chr12	56639222	Missense_Mutation	NA	R458Q	0.33
STAD	chr12	56639300	Missense_Mutation	rs745377010	K432R	0.24
STAD	chr12	56639984	Missense_Mutation	NA	L428P	0.27
STAD	chr12	56642695	Missense_Mutation	NA	R310H	0.18
STAD	chr12	56643447	Missense_Mutation	NA	M250L	0.47
STAD	chr12	56643461	Missense_Mutation	NA	D245G	0.21
STAD	chr12	56645319	Silent	novel	P54P	0.26
THCA	chr12	56643900	Missense_Mutation	NA	I182V	0.05
UCEC	chr12	56643959	Splice_Site	novel	X162_splice	0.3
UCEC	chr12	56645212	Missense_Mutation	novel	G90D	0.07
UCEC	chr12	56639143	Silent	novel	L484L	0.31
UCEC	chr12	56643455	Missense_Mutation	novel	Y247C	0.41
UCEC	chr12	56639127	Nonsense_Mutation	NA	G490*	0.15
UCEC	chr12	56640016	Missense_Mutation	novel	H417Q	0.05
UCEC	chr12	56642576	Missense_Mutation	novel	S319Y	0.04
UCEC	chr12	56642700	Silent	NA	I308I	0.27
UCEC	chr12	56643486	Missense_Mutation	NA	G237S	0.37
UCEC	chr12	56638231	3'UTR	novel		0.37
UCEC	chr12	56646052	5'UTR	novel		0.33
UCEC	chr12	56640124	Silent	novel	A381A	0.26
UCEC	chr12	56640107	Missense_Mutation	novel	R387H	0.17
UCEC	chr12	56643873	Missense_Mutation	novel	D191N	0.46
UCEC	chr12	56640052	Silent	novel	S405S	0.3
UCEC	chr12	56644802	Missense_Mutation	NA	R155T	0.61
UCEC	chr12	56639228	Missense_Mutation	rs778911180	R456H	0.33
UCEC	chr12	56644948	Silent	NA	S106S	0.3
UCEC	chr12	56645881	Frame_Shift_Del	novel	*P28Qfs56**	0.12
UCEC	chr12	56639246	Missense_Mutation	NA	D450G	0.47
UCEC	chr12	56639991	Missense_Mutation	NA	K426Q	0.43
UCEC	chr12	56645090	Intron	NA		0.43
UCEC	chr12	56643513	Missense_Mutation	novel	G228C	0.17
UCEC	chr12	56639115	Missense_Mutation	novel	I494V	0.4
UCS	chr12	56638295	3'UTR	novel		0.38
UCS	chr12	56645237	Missense_Mutation	novel	I82V	0.15

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0222	0.20414
DLBC	AMP	0.2083	0.085003
PCPG	AMP	0.0864	0.028953
READ	DEL	0.0727	0.064633

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
PRAD	0.022	Kaplan-Meier Survival Analysis
BRCA	0.00011	Kaplan-Meier Survival Analysis
ESCA	0.011	Kaplan-Meier Survival Analysis
KIRP	0.0046	Kaplan-Meier Survival Analysis
LAML	0.00065	Kaplan-Meier Survival Analysis
LIHC	0.00086	Kaplan-Meier Survival Analysis
LUAD	0.03	Kaplan-Meier Survival Analysis
UVM	0.00051	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000110955 (Gene tree)
Gene ID: 506
Gene Symbol: ATP5F1B
Alias: ATPSB|ATP5B
Full Name: ATP synthase F1 subunit beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 7,894 bases
Position: chr12:56,638,175-56,646,068
Accession: 830
RBP type: non-canonical RBP
Summary: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22261716	The role of deimination in ATP5b mRNA transport in a transgenic mouse model of multiple sclerosis.	EMBO Rep	2012 Mar 1	Ding D	doi: 10.1038/embor.2011.264.
30770472	Profiling of rotavirus 3'UTR-binding proteins reveals the ATP synthase subunit ATP5B as a host factor that supports late-stage virus replication.	J Biol Chem	2019 Apr 12	Ren L	doi: 10.1074/jbc.RA118.006004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000548474	ATP5F1B-204	449	-	-	- (aa)	-	-
ENST00000550162	ATP5F1B-206	863	-	-	- (aa)	-	-
ENST00000551020	ATP5F1B-207	856	-	ENSP00000446677	284 (aa)	-	F8W079
ENST00000551570	ATP5F1B-209	399	-	ENSP00000448428	133 (aa)	-	H0YI37
ENST00000548647	ATP5F1B-205	682	-	-	- (aa)	-	-
ENST00000553007	ATP5F1B-211	814	-	ENSP00000447571	270 (aa)	-	F8W0P7
ENST00000547250	ATP5F1B-202	840	-	-	- (aa)	-	-
ENST00000262030	ATP5F1B-201	1839	-	ENSP00000262030	529 (aa)	-	P06576
ENST00000547808	ATP5F1B-203	705	-	-	- (aa)	-	-
ENST00000552959	ATP5F1B-210	1085	-	ENSP00000446489	362 (aa)	-	H0YH81
ENST00000551182	ATP5F1B-208	457	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000110955's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00190	Oxidative phosphorylation	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04714	Thermogenesis	KEGG
hsa05010	Alzheimer disease	KEGG
hsa05012	Parkinson disease	KEGG
hsa05016	Huntington disease	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000110955	rs2950393	12	56642239	A	Platelet distribution width	27863252	[0.059-0.073] unit decrease	0.06604341	EFO_0007984
ENSG00000110955	rs10716881	12	56644387	G	High light scatter reticulocyte count	27863252	[0.014-0.029] unit decrease	0.02172399	EFO_0007986

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000110955's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000110955	ATP5F1B	86	97.619	WBGene00000229	atp-2	98	81.369	Caenorhabditis_elegans
ENSG00000110955	ATP5F1B	100	99.405	ENSMUSG00000025393	Atp5b	100	96.219	Mus_musculus
ENSG00000110955	ATP5F1B	90	88.095	YJR121W		93	78.378	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001525	angiogenesis	17510399.	IMP	Process
GO:0001649	osteoblast differentiation	16210410.	HDA	Process
GO:0005215	transporter activity	2870059.	NAS	Function
GO:0005515	protein binding	10077593.11410595.15161933.20618440.21106936.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	2870059.	IDA	Component
GO:0005753	mitochondrial proton-transporting ATP synthase complex	12110673.	IDA	Component
GO:0005754	mitochondrial proton-transporting ATP synthase, catalytic core	2870059.	NAS	Component
GO:0005759	mitochondrial matrix	2687158.	NAS	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005886	plasma membrane	10077593.	IDA	Component
GO:0006091	generation of precursor metabolites and energy	2870059.	NAS	Process
GO:0006629	lipid metabolic process	-	IEA	Process
GO:0006754	ATP biosynthetic process	17510399.21106936.	IMP	Process
GO:0006754	ATP biosynthetic process	-	TAS	Process
GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration	-	IEA	Process
GO:0007005	mitochondrion organization	-	TAS	Process
GO:0009986	cell surface	17510399.	IDA	Component
GO:0016020	membrane	16210410.19946888.	HDA	Component
GO:0016020	membrane	21106936.	IDA	Component
GO:0016887	ATPase activity	12110673.	IDA	Function
GO:0022857	transmembrane transporter activity	12110673.	IC	Function
GO:0031966	mitochondrial membrane	8006588.	IDA	Component
GO:0042288	MHC class I protein binding	17643490.	IDA	Function
GO:0042407	cristae formation	-	TAS	Process
GO:0042645	mitochondrial nucleoid	18063578.	IDA	Component
GO:0042776	mitochondrial ATP synthesis coupled proton transport	12110673.	IC	Process
GO:0042776	mitochondrial ATP synthesis coupled proton transport	-	TAS	Process
GO:0043532	angiostatin binding	21106936.	IPI	Function
GO:0043536	positive regulation of blood vessel endothelial cell migration	21106936.	IGI	Process
GO:0045259	proton-transporting ATP synthase complex	21106936.	IDA	Component
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	21106936.	IMP	Function
GO:0046961	proton-transporting ATPase activity, rotational mechanism	17510399.	IMP	Function
GO:0051453	regulation of intracellular pH	17510399.	IMP	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0098761	cellular response to interleukin-7	-	IEA	Process
GO:0099132	ATP hydrolysis coupled cation transmembrane transport	-	IEA	Process
GO:1902600	proton transmembrane transport	17510399.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.