EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18264137	Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation.	Oncogene	2008 Jun 26	Tucker LA	doi: 10.1038/onc.2008.14
11994292	Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4.	J Biol Chem	2002 Jul 19	Endo H	-
15336565	Expression of methionine aminopeptidase 2, N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29.	Biochem Biophys Res Commun	2004 Sep 24	Selvakumar P	-
27542228	MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.	Oncotarget	2016 Sep 27	Frottin F	doi: 10.18632/oncotarget.11216.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr12	95474141	5'UTR	rs113274711		0.2
BLCA	chr12	95496051	Missense_Mutation	novel	D274N	0.26
BLCA	chr12	95496096	Missense_Mutation	novel	K289Q	0.43
BLCA	chr12	95512891	Missense_Mutation	NA	F387V	0.42
BLCA	chr12	95474141	5'UTR	rs113274711		0.31
BLCA	chr12	95474162	5'UTR	novel		0.19
BRCA	chr12	95513720	Missense_Mutation	novel	R418K	0.3
BRCA	chr12	95495123	Nonsense_Mutation	NA	G253*	0.57
BRCA	chr12	95495124	Missense_Mutation	NA	G253V	0.58
BRCA	chr12	95514264	3'UTR	novel		0.07
BRCA	chr12	95494980	Missense_Mutation	rs752983315	R205H	0.04
BRCA	chr12	95511981	Missense_Mutation	novel	E351K	0.1
BRCA	chr12	95494958	Nonsense_Mutation	NA	E198*	0.1
BRCA	chr12	95511897	Nonsense_Mutation	NA	K323*	0.11
CESC	chr12	95496051	Missense_Mutation	novel	D274N	0.18
CESC	chr12	95485947	Nonsense_Mutation	novel	G132*	0.5
CESC	chr12	95514418	3'UTR	novel		0.63
CESC	chr12	95494206	Missense_Mutation	novel	M193I	0.38
COAD	chr12	95513835	Silent	rs112506052	A456A	0.29
COAD	chr12	95476078	Silent	novel	E53E	0.06
COAD	chr12	95485953	Nonsense_Mutation	novel	E134*	0.17
COAD	chr12	95494100	Missense_Mutation	NA	L158S	0.26
COAD	chr12	95476142	Missense_Mutation	NA	A75T	0.37
COAD	chr12	95511925	Nonsense_Mutation	NA	S332*	0.19
COAD	chr12	95494090	Missense_Mutation	NA	K155Q	0.46
COAD	chr12	95513963	3'UTR	novel		0.21
COAD	chr12	95512823	Frame_Shift_Del	novel	*T365Pfs20**	0.23
COAD	chr12	95504105	Missense_Mutation	NA	A303V	0.09
COAD	chr12	95476085	Frame_Shift_Ins	novel	*P56Qfs14**	0.07
COAD	chr12	95476086	Frame_Shift_Ins	novel	*D57Lfs3**	0.07
ESCA	chr12	95512825	Missense_Mutation	novel	T365A	0.6
GBM	chr12	95474275	Missense_Mutation	novel	E32D	0.41
HNSC	chr12	95474295	Missense_Mutation	novel	R39T	0.17
HNSC	chr12	95494084	Missense_Mutation	novel	E153K	0.2
HNSC	chr12	95476070	Splice_Site	novel	X51_splice	0.36
KIRC	chr12	95494955	Splice_Site	rs781369643	X197_splice	0.26
KIRP	chr12	95513892	Silent	novel	G475G	0.28
KIRP	chr12	95513662	Missense_Mutation	NA	T399A	0.24
KIRP	chr12	95513928	3'UTR	rs773051862		0.17
KIRP	chr12	95474069	5'UTR	novel		0.79
LGG	chr12	95494057	Nonsense_Mutation	rs780306578	R144*	0.45
LGG	chr12	95511940	Missense_Mutation	novel	R337I	0.22
LGG	chr12	95513866	Missense_Mutation	novel	T467A	0.08
LIHC	chr12	95474192	Missense_Mutation	novel	E5K	0.43
LIHC	chr12	95511902	Silent	NA	P324P	0.3
LIHC	chr12	95474184	Missense_Mutation	novel	A2V	0.22
LUAD	chr12	95474178	5'UTR	novel		0.44
LUAD	chr12	95483249	Missense_Mutation	novel	K98N	0.26
LUAD	chr12	95476135	Frame_Shift_Ins	novel	*R73Nfs9**	0.13
LUAD	chr12	95476137	Missense_Mutation	novel	R73K	0.13
LUSC	chr12	95474269	Silent	novel	T30T	0.15
LUSC	chr12	95513705	Missense_Mutation	NA	L413P	0.22
LUSC	chr12	95513656	Missense_Mutation	NA	P397S	0.25
LUSC	chr12	95514030	3'UTR	novel		0.24
LUSC	chr12	95474089	5'UTR	novel		0.27
LUSC	chr12	95511934	Frame_Shift_Del	novel	*Q335Hfs13**	0.27
OV	chr12	95513890	Missense_Mutation	NA	G475R	0.25
OV	chr12	95494173	Silent	rs141578207	Y182Y	0.44
PAAD	chr12	95513717	Missense_Mutation	NA	R417H	0.04
PRAD	chr12	95474256	Missense_Mutation	novel	G26E	0.34
PRAD	chr12	95495133	Missense_Mutation	NA	I256T	0.28
READ	chr12	95476155	Missense_Mutation	novel	K79T	0.43
READ	chr12	95485913	Missense_Mutation	novel	I120M	0.25
SARC	chr12	95514060	3'UTR	novel		0.4
SKCM	chr12	95476112	Missense_Mutation	NA	D65N	0.51
SKCM	chr12	95474099	5'UTR	novel		0.68
SKCM	chr12	95474069	5'UTR	novel		0.45
SKCM	chr12	95511905	Silent	novel	I325I	0.29
SKCM	chr12	95485896	Missense_Mutation	NA	P115S	0.35
SKCM	chr12	95474070	5'UTR	novel		0.27
SKCM	chr12	95496022	Missense_Mutation	novel	A264V	0.22
SKCM	chr12	95474069	5'UTR	novel		0.29
SKCM	chr12	95494061	Missense_Mutation	NA	T145R	0.57
SKCM	chr12	95474054	5'UTR	novel		0.25
SKCM	chr12	95513731	Missense_Mutation	rs754957570	R422C	0.18
STAD	chr12	95512891	Missense_Mutation	NA	F387V	0.32
STAD	chr12	95494980	Missense_Mutation	rs752983315	R205H	0.33
STAD	chr12	95494083	Silent	NA	S152S	0.61
STAD	chr12	95513945	3'UTR	novel		0.08
UCEC	chr12	95474302	Silent	NA	K41K	0.42
UCEC	chr12	95511963	Missense_Mutation	novel	P345S	0.18
UCEC	chr12	95511920	Silent	rs757091265	G330G	0.36
UCEC	chr12	95496099	Splice_Site	novel	X289_splice	0.47
UCEC	chr12	95511906	Missense_Mutation	novel	R326C	0.21
UCEC	chr12	95494060	Missense_Mutation	rs776632195	T145A	0.1
UCEC	chr12	95495034	Missense_Mutation	novel	C223Y	0.18
UCEC	chr12	95485881	Missense_Mutation	rs200917784	K110E	0.28
UCEC	chr12	95504083	Missense_Mutation	novel	R296C	0.3
UCEC	chr12	95476092	Missense_Mutation	NA	K58T	0.32
UCEC	chr12	95496056	Silent	rs764203985	T275T	0.11
UCEC	chr12	95495068	Silent	novel	P234P	0.2
UCEC	chr12	95515268	3'UTR	novel		0.25
UCEC	chr12	95512891	Missense_Mutation	NA	F387V	0.44
UCEC	chr12	95476132	Silent	rs200315154	L71L	0.5
UCEC	chr12	95494092	Missense_Mutation	novel	K155N	0.53
UCEC	chr12	95514199	3'UTR	novel		0.37
UCEC	chr12	95483225	Silent	rs200687006	G90G	0.29
UCEC	chr12	95513967	3'UTR	novel		0.31
UCEC	chr12	95511912	Missense_Mutation	novel	L328I	0.3
UCEC	chr12	95474294	Missense_Mutation	novel	R39G	0.52
UCEC	chr12	95496055	Missense_Mutation	rs201728792	T275M	0.34
UCEC	chr12	95514199	3'UTR	novel		0.42
UCEC	chr12	95514306	3'UTR	novel		0.4
UCEC	chr12	95476104	Missense_Mutation	novel	A62V	0.67
UCEC	chr12	95512902	Silent	novel	G390G	0.51
UCEC	chr12	95513712	Missense_Mutation	novel	F415L	0.53
UCEC	chr12	95514199	3'UTR	novel		0.14
UCEC	chr12	95512856	Missense_Mutation	NA	H375R	0.15
UCEC	chr12	95494210	Nonsense_Mutation	novel	E195*	0.46
UCEC	chr12	95514980	3'UTR	novel		0.57
UCEC	chr12	95483225	Silent	rs200687006	G90G	0.27
UCEC	chr12	95496010	Missense_Mutation	novel	I260S	0.15
UCEC	chr12	95514989	3'UTR	novel		0.24
UCEC	chr12	95474132	5'UTR	rs764222648		0.32
UCEC	chr12	95494119	Missense_Mutation	rs147951626	E164D	0.32
UCEC	chr12	95494189	Missense_Mutation	NA	K188E	0.19
UCEC	chr12	95514045	3'UTR	novel		0.5
UCEC	chr12	95512882	Missense_Mutation	NA	M384V	0.46
UCEC	chr12	95511999	Splice_Site	novel	X356_splice	0.11
UCEC	chr12	95504149	Nonsense_Mutation	novel	K318delinsMVKCG*	0.03
UCEC	chr12	95494173	Silent	rs141578207	Y182Y	0.3
UCEC	chr12	95496067	Missense_Mutation	novel	A279V	0.33
UCEC	chr12	95496052	Missense_Mutation	NA	D274G	0.28
UCEC	chr12	95474281	Silent	novel	A34A	0.44
UCS	chr12	95474325	Missense_Mutation	rs199968706	S49Y	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0222	0.20414
CHOL	DEL	0.1944	0.067545
ESCA	DEL	0.163	0.045584
HNSC	DEL	0.0651	0.22646
LAML	DEL	0.0105	0.097556
LUAD	DEL	0.1434	0.0059643
MESO	DEL	0.046	0.014499
PAAD	AMP	0.0598	0.1091
PAAD	DEL	0.1902	0.2014
PRAD	AMP	0.061	0.016187
READ	DEL	0.0909	0.064633
SKCM	DEL	0.1989	0.00079981

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.0058	Kaplan-Meier Survival Analysis
UCS	0.014	Kaplan-Meier Survival Analysis
HNSC	0.028	Kaplan-Meier Survival Analysis
KIRP	0.0018	Kaplan-Meier Survival Analysis
KICH	0.047	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

PRI

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000111142 (Gene tree)
Gene ID: 10988
Gene Symbol: METAP2
Alias: MNPEP|p67|MAP2
Full Name: methionyl aminopeptidase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 42,320 bases
Position: chr12:95,473,520-95,515,839
Accession: 16672
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000546753	METAP2-205	1862	-	ENSP00000448169	455 (aa)	-	P50579
ENST00000549502	METAP2-207	513	-	ENSP00000448370	161 (aa)	-	F8VSC4
ENST00000553151	METAP2-211	564	-	ENSP00000449004	178 (aa)	-	F8VY03
ENST00000261220	METAP2-201	1836	-	ENSP00000261220	455 (aa)	-	P50579
ENST00000549808	METAP2-208	538	-	ENSP00000447661	163 (aa)	-	F8VZX9
ENST00000549136	METAP2-206	388	-	-	- (aa)	-	-
ENST00000535095	METAP2-203	2431	-	ENSP00000446052	328 (aa)	-	G3V1U3
ENST00000323666	METAP2-202	3601	-	ENSP00000325312	478 (aa)	-	P50579
ENST00000550777	METAP2-209	1779	-	ENSP00000448614	442 (aa)	-	F8VRR3
ENST00000551840	METAP2-210	1874	-	ENSP00000450063	477 (aa)	-	F8VQZ7
ENST00000546478	METAP2-204	232	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000111142's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000111142	rs301043	12	95493245	G	Immature fraction of reticulocytes	27863252	[0.024-0.039] unit decrease	0.03181796	EFO_0007986

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111142's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000111142	METAP2	100	95.188	ENSMUSG00000036112	Metap2	100	99.057	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004177	aminopeptidase activity	8858118.	IDA	Function
GO:0005737	cytoplasm	15102683.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0008235	metalloexopeptidase activity	8858118.	IDA	Function
GO:0016485	protein processing	8858118.	IDA	Process
GO:0018206	peptidyl-methionine modification	8858118.	IDA	Process
GO:0022400	regulation of rhodopsin mediated signaling pathway	-	TAS	Process
GO:0031365	N-terminal protein amino acid modification	8858118.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0070006	metalloaminopeptidase activity	-	IEA	Function
GO:0070084	protein initiator methionine removal	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

PRI

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.