EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28562428	Single nucleotide variant in Nucleoporin 107 may be predictive of sensitivity to chemotherapy in patients with ovarian cancer.	Pharmacogenet Genomics	2017 Jul	Alanee S	doi: 10.1097/FPC.0000000000000288.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr12	68687102	Intron	novel		0.46
BLCA	chr12	68710025	Missense_Mutation	novel	E274D	0.29
BLCA	chr12	68686949	5'UTR	novel		0.23
BLCA	chr12	68713789	Missense_Mutation	rs766185011	R317H	0.24
BLCA	chr12	68696826	Missense_Mutation	novel	M152I	0.51
BLCA	chr12	68719578	Missense_Mutation	NA	G392A	0.26
BLCA	chr12	68709282	Missense_Mutation	novel	Q258H	0.39
BLCA	chr12	68727356	Missense_Mutation	NA	E567D	0.15
BLCA	chr12	68732694	Missense_Mutation	NA	A686S	0.32
BLCA	chr12	68733586	Nonsense_Mutation	NA	E746*	0.06
BLCA	chr12	68726513	Frame_Shift_Del	novel	*S532Pfs15**	0.11
BLCA	chr12	68734717	Nonsense_Mutation	novel	E758*	0.12
BRCA	chr12	68713776	Missense_Mutation	rs139969249	V313I	0.13
BRCA	chr12	68687082	Intron	novel		0.23
BRCA	chr12	68689036	Missense_Mutation	NA	A28G	0.13
BRCA	chr12	68741930	Missense_Mutation	NA	C874R	0.27
BRCA	chr12	68735262	Missense_Mutation	rs375498676	D807G	0.09
BRCA	chr12	68732726	Missense_Mutation	NA	M696I	0.29
BRCA	chr12	68700737	Silent	NA	L188L	0.34
BRCA	chr12	68686996	5'UTR	novel		0.14
BRCA	chr12	68721131	Missense_Mutation	NA	R422I	0.11
BRCA	chr12	68734824	Missense_Mutation	NA	K793N	0.14
BRCA	chr12	68741898	Missense_Mutation	rs753777420	T863M	0.14
BRCA	chr12	68686996	5'UTR	novel		0.27
BRCA	chr12	68710050	Missense_Mutation	NA	E283K	0.1
CESC	chr12	68687126	Intron	NA		0.36
CESC	chr12	68726523	Missense_Mutation	novel	W534L	0.16
CESC	chr12	68688997	Missense_Mutation	NA	R15Q	0.1
CESC	chr12	68731687	Missense_Mutation	novel	L656M	0.38
CESC	chr12	68735302	Silent	novel	V820V	0.4
CESC	chr12	68689605	Nonsense_Mutation	NA	S58*	0.22
COAD	chr12	68731228	Missense_Mutation	NA	R618H	0.18
COAD	chr12	68732735	Missense_Mutation	rs764792538	F699L	0.27
COAD	chr12	68742576	3'UTR	novel		0.47
COAD	chr12	68709254	Frame_Shift_Del	novel	*T251Qfs20**	0.28
COAD	chr12	68741873	Missense_Mutation	novel	P855S	0.16
COAD	chr12	68733592	Missense_Mutation	novel	L748V	0.13
COAD	chr12	68687115	Intron	novel		0.18
COAD	chr12	68689565	Missense_Mutation	NA	T45A	0.42
COAD	chr12	68686945	5'UTR	novel		0.31
COAD	chr12	68689008	Missense_Mutation	novel	V19M	0.24
COAD	chr12	68735299	Silent	NA	N819N	0.6
COAD	chr12	68689565	Missense_Mutation	NA	T45A	0.3
COAD	chr12	68689053	Missense_Mutation	rs752554807	L34F	0.14
COAD	chr12	68700753	Nonsense_Mutation	rs774346160	R194*	0.21
COAD	chr12	68709272	Missense_Mutation	rs752069314	A255V	0.28
COAD	chr12	68731219	Missense_Mutation	NA	F615C	0.09
COAD	chr12	68731706	Missense_Mutation	NA	T662N	0.42
COAD	chr12	68732639	Splice_Region	NA	E667E	0.26
COAD	chr12	68690602	Intron	novel		0.31
COAD	chr12	68686975	5'UTR	novel		0.45
COAD	chr12	68731165	Missense_Mutation	novel	P597R	0.33
ESCA	chr12	68733521	Missense_Mutation	rs780651405	Y724C	0.22
ESCA	chr12	68690640	Missense_Mutation	novel	T66R	0.32
ESCA	chr12	68709306	Missense_Mutation	novel	S266R	0.15
GBM	chr12	68733596	Missense_Mutation	novel	C749F	0.07
GBM	chr12	68735299	Silent	NA	N819N	0.45
GBM	chr12	68686977	5'UTR	novel		0.06
GBM	chr12	68721890	Missense_Mutation	rs766395497	R454Q	0.32
GBM	chr12	68690616	Intron	novel		0.05
GBM	chr12	68687127	Intron	novel		0.19
GBM	chr12	68731141	Missense_Mutation	rs752781760	I589T	0.1
HNSC	chr12	68741948	Missense_Mutation	rs747127320	M880V	0.47
HNSC	chr12	68687086	Intron	novel		0.08
HNSC	chr12	68715627	Missense_Mutation	novel	D324Y	0.3
HNSC	chr12	68721852	Silent	novel	V441V	0.35
HNSC	chr12	68686934	5'UTR	novel		0.12
HNSC	chr12	68687000	5'UTR	novel		0.21
KIRC	chr12	68742577	3'UTR	novel		0.13
KIRC	chr12	68742579	3'UTR	novel		0.13
KIRC	chr12	68742437	Missense_Mutation	NA	P918Q	0.46
KIRP	chr12	68687214	Intron	novel		0.35
LAML	chr12	68686973	5'UTR	novel		0.16
LGG	chr12	68700846	Frame_Shift_Ins	novel	*L225Sfs13**	0.13
LGG	chr12	68691979	Silent	novel	L105L	0.08
LGG	chr12	68687032	5'UTR	rs754753199		0.05
LGG	chr12	68689566	Missense_Mutation	novel	T45N	0.09
LGG	chr12	68733612	Frame_Shift_Ins	novel	*E755Mfs15**	0.06
LUAD	chr12	68702757	Missense_Mutation	novel	L234F	0.26
LUAD	chr12	68733466	Missense_Mutation	novel	E706Q	0.21
LUAD	chr12	68727353	Missense_Mutation	novel	E566D	0.15
LUAD	chr12	68727354	Nonsense_Mutation	novel	E567*	0.15
LUAD	chr12	68690662	Missense_Mutation	NA	Q73H	0.3
LUAD	chr12	68696817	Splice_Site	novel	X150_splice	0.48
LUAD	chr12	68735315	Missense_Mutation	novel	D825N	0.05
LUAD	chr12	68709300	Silent	novel	R264R	0.53
LUAD	chr12	68690736	Missense_Mutation	NA	N98I	0.17
LUAD	chr12	68691997	Silent	novel	A111A	0.3
LUAD	chr12	68735276	Missense_Mutation	NA	D812N	0.26
LUAD	chr12	68721970	Missense_Mutation	NA	E481Q	0.42
LUSC	chr12	68742366	Silent	novel	K894K	0.28
LUSC	chr12	68726564	Missense_Mutation	rs764034347	R548C	0.32
LUSC	chr12	68732669	Missense_Mutation	NA	W677C	0.42
LUSC	chr12	68690700	Missense_Mutation	rs138414891	S86L	0.11
LUSC	chr12	68692061	Missense_Mutation	NA	D133H	0.16
LUSC	chr12	68731666	Missense_Mutation	novel	G649C	0.28
LUSC	chr12	68721873	Silent	novel	T448T	0.2
LUSC	chr12	68725789	Silent	novel	D523D	0.24
LUSC	chr12	68687016	5'UTR	novel		0.23
LUSC	chr12	68687004	5'UTR	novel		0.2
OV	chr12	68733472	Missense_Mutation	novel	A708S	0.07
OV	chr12	68742511	3'UTR	novel		0.17
OV	chr12	68741843	Missense_Mutation	NA	Q845E	0.31
PAAD	chr12	68731652	Missense_Mutation	rs778938533	R644Q	0.07
PRAD	chr12	68709309	Splice_Region	NA	Q267Q	0.13
PRAD	chr12	68700753	Silent	NA	R194R	0.32
PRAD	chr12	68692001	Missense_Mutation	NA	A113S	0.11
PRAD	chr12	68700823	Missense_Mutation	novel	V217A	0.42
PRAD	chr12	68713738	Missense_Mutation	novel	T300N	0.3
READ	chr12	68687023	5'UTR	novel		0.41
READ	chr12	68742485	3'UTR	novel		0.29
READ	chr12	68731673	Missense_Mutation	NA	F651C	0.28
READ	chr12	68732728	Missense_Mutation	NA	R697K	0.31
READ	chr12	68710041	Nonsense_Mutation	novel	E280*	0.27
READ	chr12	68709299	Missense_Mutation	NA	R264Q	0.21
SARC	chr12	68719583	Missense_Mutation	novel	E394Q	0.42
SARC	chr12	68692044	Missense_Mutation	novel	P127H	0.39
SARC	chr12	68727353	Missense_Mutation	novel	E566D	0.05
SKCM	chr12	68721158	Missense_Mutation	NA	L431S	0.37
SKCM	chr12	68742443	Missense_Mutation	novel	G920E	0.32
SKCM	chr12	68742444	Silent	novel	G920G	0.32
SKCM	chr12	68686963	5'UTR	novel		0.44
SKCM	chr12	68731231	Missense_Mutation	novel	H619R	0.31
SKCM	chr12	68733496	Missense_Mutation	NA	P716S	0.34
SKCM	chr12	68715631	Missense_Mutation	NA	P325L	0.3
SKCM	chr12	68689538	Missense_Mutation	novel	A36T	0.19
SKCM	chr12	68686963	5'UTR	novel		0.46
SKCM	chr12	68686981	5'UTR	novel		0.66
SKCM	chr12	68719608	Missense_Mutation	novel	P402L	0.71
SKCM	chr12	68726529	Missense_Mutation	NA	S536F	0.69
SKCM	chr12	68726529	Missense_Mutation	NA	S536F	0.36
SKCM	chr12	68689593	Missense_Mutation	rs139991199	R54Q	0.07
SKCM	chr12	68731254	Missense_Mutation	NA	E627K	0.38
SKCM	chr12	68700842	Silent	NA	A223A	0.23
SKCM	chr12	68719368	Nonsense_Mutation	novel	Q371*	0.3
SKCM	chr12	68690743	Silent	novel	S100S	0.69
SKCM	chr12	68686963	5'UTR	novel		0.43
SKCM	chr12	68721964	Missense_Mutation	novel	P479S	0.88
SKCM	chr12	68715637	Missense_Mutation	NA	A327V	0.32
SKCM	chr12	68721136	Missense_Mutation	NA	E424K	0.07
SKCM	chr12	68726564	Missense_Mutation	rs764034347	R548C	0.43
SKCM	chr12	68715719	Silent	novel	I354I	0.44
SKCM	chr12	68715720	Missense_Mutation	novel	R355C	0.43
SKCM	chr12	68733496	Missense_Mutation	NA	P716S	0.41
SKCM	chr12	68686971	5'UTR	novel		0.35
SKCM	chr12	68686972	5'UTR	novel		0.36
STAD	chr12	68715630	Missense_Mutation	NA	P325T	0.19
STAD	chr12	68726604	Missense_Mutation	novel	G561E	0.13
STAD	chr12	68719403	Silent	NA	K382K	0.32
STAD	chr12	68742431	Missense_Mutation	novel	L916R	0.08
STAD	chr12	68709273	Silent	rs760015459	A255A	0.34
STAD	chr12	68702778	Frame_Shift_Del	novel	*V242Lfs29**	0.26
STAD	chr12	68715657	Missense_Mutation	NA	P334S	0.29
STAD	chr12	68719616	Missense_Mutation	rs201038520	R405C	0.21
STAD	chr12	68734729	Missense_Mutation	NA	E762K	0.46
STAD	chr12	68734826	Missense_Mutation	NA	K794T	0.31
STAD	chr12	68733480	Missense_Mutation	NA	E710D	0.06
STAD	chr12	68692093	Missense_Mutation	NA	E143D	0.2
STAD	chr12	68715682	Missense_Mutation	NA	D342G	0.2
STAD	chr12	68713784	Silent	rs777203994	S315S	0.18
STAD	chr12	68741901	Missense_Mutation	NA	I864T	0.35
STAD	chr12	68732648	Frame_Shift_Del	novel	*I672Lfs3**	0.3
UCEC	chr12	68709299	Missense_Mutation	NA	R264Q	0.29
UCEC	chr12	68727366	Missense_Mutation	novel	E571K	0.09
UCEC	chr12	68700849	Missense_Mutation	NA	Y226H	0.16
UCEC	chr12	68709298	Nonsense_Mutation	rs768060090	R264*	0.18
UCEC	chr12	68732643	Missense_Mutation	NA	R669C	0.36
UCEC	chr12	68733462	Missense_Mutation	NA	K704N	0.32
UCEC	chr12	68734746	Missense_Mutation	NA	M767I	0.35
UCEC	chr12	68702775	Silent	rs778594241	F240F	0.43
UCEC	chr12	68735286	Missense_Mutation	novel	E815G	0.32
UCEC	chr12	68734738	Missense_Mutation	NA	K765E	0.29
UCEC	chr12	68687032	5'UTR	novel		0.46
UCEC	chr12	68719348	Missense_Mutation	novel	R364Q	0.31
UCEC	chr12	68732735	Missense_Mutation	rs764792538	F699L	0.19
UCEC	chr12	68689547	Missense_Mutation	novel	D39Y	0.06
UCEC	chr12	68710025	Missense_Mutation	novel	E274D	0.07
UCEC	chr12	68741963	Missense_Mutation	rs768676886	R885C	0.27
UCEC	chr12	68687052	5'UTR	rs776359144		0.5
UCEC	chr12	68689023	Missense_Mutation	NA	R24W	0.33
UCEC	chr12	68686978	5'UTR	novel		0.12
UCEC	chr12	68715684	Nonsense_Mutation	NA	E343*	0.09
UCEC	chr12	68725775	Missense_Mutation	novel	L519I	0.16
UCEC	chr12	68689610	Nonsense_Mutation	novel	R60*	0.35
UCEC	chr12	68710032	Missense_Mutation	novel	A277T	0.16
UCEC	chr12	68733502	Missense_Mutation	novel	D718Y	0.44
UCEC	chr12	68731134	Missense_Mutation	novel	N587H	0.34
UCEC	chr12	68732730	Missense_Mutation	novel	K698E	0.2
UCEC	chr12	68689610	Nonsense_Mutation	novel	R60*	0.32
UCEC	chr12	68686941	5'UTR	novel		0.31
UCEC	chr12	68731652	Missense_Mutation	rs778938533	R644Q	0.12
UCEC	chr12	68709272	Missense_Mutation	rs752069314	A255V	0.36
UCEC	chr12	68713775	Silent	rs370818496	Y312Y	0.38
UCEC	chr12	68733570	Silent	novel	D740D	0.37
UCEC	chr12	68689610	Nonsense_Mutation	novel	R60*	0.45
UCEC	chr12	68721148	Missense_Mutation	novel	Y428H	0.58
UCEC	chr12	68687194	Intron	novel		0.29
UCEC	chr12	68731254	Nonsense_Mutation	novel	E627*	0.14
UCEC	chr12	68719636	Nonsense_Mutation	novel	C411*	0.19
UCEC	chr12	68731227	Missense_Mutation	rs780361704	R618C	0.4
UCEC	chr12	68734787	Missense_Mutation	novel	T781I	0.19
UCEC	chr12	68725794	Missense_Mutation	NA	D525G	0.06
UCEC	chr12	68715684	Nonsense_Mutation	NA	E343*	0.24
UCEC	chr12	68742540	3'UTR	novel		0.3
UCEC	chr12	68715721	Missense_Mutation	rs747135247	R355H	0.2
UCEC	chr12	68731228	Missense_Mutation	NA	R618H	0.39
UCEC	chr12	68700832	Missense_Mutation	novel	R220M	0.33
UCEC	chr12	68709239	Missense_Mutation	NA	A244D	0.39
UCEC	chr12	68722104	Splice_Region	NA	N486N	0.28
UCEC	chr12	68709245	Missense_Mutation	novel	N246I	0.39
UCEC	chr12	68713760	Silent	rs775863283	R307R	0.44
UCEC	chr12	68719595	Missense_Mutation	novel	V398I	0.23
UCEC	chr12	68721169	Missense_Mutation	novel	L435F	0.36
UCEC	chr12	68700781	Frame_Shift_Ins	novel	*T205Nfs23**	0.44
UCS	chr12	68690606	Intron	novel		0.33
UCS	chr12	68702758	Nonsense_Mutation	novel	E235*	0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0333	0.20414
DLBC	AMP	0.2083	0.085003
GBM	DEL	0.0849	0.0052524
LUSC	AMP	0.2415	0.00092392
PAAD	AMP	0.1141	0.0061805
READ	DEL	0.0909	0.064633
SKCM	AMP	0.1226	9.9717e-11

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0023	Kaplan-Meier Survival Analysis
KIRC	0.0011	Kaplan-Meier Survival Analysis
STAD	0.037	Kaplan-Meier Survival Analysis
SARC	0.01	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.0043	Kaplan-Meier Survival Analysis
PRAD	0.02	Kaplan-Meier Survival Analysis
KIRP	0.0032	Kaplan-Meier Survival Analysis
PAAD	0.027	Kaplan-Meier Survival Analysis
READ	0.049	Kaplan-Meier Survival Analysis
LAML	0.015	Kaplan-Meier Survival Analysis
KICH	0.0015	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.0061	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000111581 (Gene tree)
Gene ID: 57122
Gene Symbol: NUP107
Alias: NUP84
Full Name: nucleoporin 107
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 59,076 bases
Position: chr12:68,686,734-68,745,809
Accession: 29914
RBP type: non-canonical RBP
Summary: This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000540453	NUP107-212	573	-	-	- (aa)	-	-
ENST00000537662	NUP107-207	825	-	-	- (aa)	-	-
ENST00000539373	NUP107-210	278	-	-	- (aa)	-	-
ENST00000535718	NUP107-205	2655	-	ENSP00000445567	103 (aa)	-	G3V1T4
ENST00000401003	NUP107-203	729	-	-	- (aa)	-	-
ENST00000538549	NUP107-208	678	-	ENSP00000440116	85 (aa)	-	F5GY77
ENST00000378905	NUP107-202	2859	-	ENSP00000368185	686 (aa)	-	P57740
ENST00000538993	NUP107-209	836	-	ENSP00000441334	80 (aa)	-	H0YG15
ENST00000535333	NUP107-204	683	-	-	- (aa)	-	-
ENST00000545140	NUP107-213	516	-	-	- (aa)	-	-
ENST00000539906	NUP107-211	3004	-	ENSP00000441448	896 (aa)	-	P57740
ENST00000537598	NUP107-206	695	-	-	- (aa)	-	-
ENST00000229179	NUP107-201	6457	XM_005269037	ENSP00000229179	925 (aa)	XP_005269094	P57740

Gene Model

Click here to download ENSG00000111581's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111581's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000776	kinetochore	17363900.	IDA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0000973	posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery	21873635.	IBA	Process
GO:0005515	protein binding	11564755.15146057.17363900.24407287.26411495.26496610.27194810.	IPI	Function
GO:0005635	nuclear envelope	-	TAS	Component
GO:0005643	nuclear pore	11564755.11684705.12802065.15229283.26411495.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006110	regulation of glycolytic process	-	TAS	Process
GO:0006406	mRNA export from nucleus	21873635.	IBA	Process
GO:0006406	mRNA export from nucleus	11684705.	IDA	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0006409	tRNA export from nucleus	-	TAS	Process
GO:0006606	protein import into nucleus	21873635.	IBA	Process
GO:0008585	female gonad development	26485283.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	TAS	Process
GO:0016925	protein sumoylation	-	TAS	Process
GO:0017056	structural constituent of nuclear pore	21873635.	IBA	Function
GO:0017056	structural constituent of nuclear pore	11684705.	IDA	Function
GO:0017056	structural constituent of nuclear pore	15229283.	IMP	Function
GO:0019083	viral transcription	-	TAS	Process
GO:0031080	nuclear pore outer ring	21873635.	IBA	Component
GO:0031080	nuclear pore outer ring	17360435.	IDA	Component
GO:0031080	nuclear pore outer ring	15146057.17363900.	NAS	Component
GO:0031965	nuclear membrane	12802065.15229283.	IDA	Component
GO:0034399	nuclear periphery	15229283.	IDA	Component
GO:0043657	host cell	-	IEA	Component
GO:0051292	nuclear pore complex assembly	15229283.	IMP	Process
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process
GO:0072006	nephron development	30179222.	IMP	Process
GO:0075733	intracellular transport of virus	-	TAS	Process
GO:1900034	regulation of cellular response to heat	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.