EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23988223Glyceraldehyde-3-phosphate dehydrogenase gene over expression correlates with poor prognosis in non small cell lung cancer patients.Mol Cancer2013 Aug 29Puzone Rdoi: 10.1186/1476-4598-12-97.
19161537Expression of CPEB, GAPDH and U6snRNA in cervical and ovarian tissue during cancer development.APMIS2009 JanHansen CNdoi: 10.1111/j.1600-0463.2008.00015.x.
15001839Cten mRNA expression is correlated with tumor progression in thymoma.Tumour Biol2003 Sep-OctSasaki H-
17597534GAPDH is not regulated in human glioblastoma under hypoxic conditions.BMC Mol Biol2007 Jun 27Said HM-
22350014Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-bromopyruvate propyl ester.J Bioenerg Biomembr2012 FebTang Zdoi: 10.1007/s10863-012-9420-9
25944804Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment.Clin Cancer Res2015 Aug 15Bazzocco Sdoi: 10.1158/1078-0432.CCR-14-2457
19800890Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation.J Mol Biol2009 Dec 11Demarse NAdoi: 10.1016/j.jmb.2009.09.062
21979951Akt2 kinase suppresses glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-mediated apoptosis in ovarian cancer cells via phosphorylating GAPDH at threonine 237 and decreasing its nuclear translocation.J Biol Chem2011 Dec 9Huang Qdoi: 10.1074/jbc.M111.296905
17540725Involvement of glyceraldehyde-3-phosphate dehydrogenase in tumor necrosis factor-related apoptosis-inducing ligand-mediated death of thyroid cancer cells.Endocrinology2007 SepDu ZX-
26713364Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH.Biochem Biophys Res Commun2016 Feb 12Lazarev VFdoi: 10.1016/j.bbrc.2015.12.076
22847419Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA component.Proc Natl Acad Sci U S A2012 Aug 14Nicholls Cdoi: 10.1073/pnas.1206672109
16515701The effect of bisphosphonates on gene expression: GAPDH as a housekeeping or a new target gene?BMC Cancer2006 Mar 3Valenti MT-
21338575Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells.Arch Biochem Biophys2011 May 1Higashimura Ydoi: 10.1016/j.abb.2011.02.011
20664973Glyceraldehyde-3-phosphate dehydrogenase as a surface associated antigen on human breast cancer cell lines MACL-1 and MGSO-3.Oncol Rep2010 SepCorrea CR-
17553795Glyceraldehyde-3-phosphate dehydrogenase enhances transcriptional activity of androgen receptor in prostate cancer cells.J Biol Chem2007 Aug 3Harada N-
19747091Molecular characterization of tumor associated glyceraldehyde-3-phosphate dehydrogenase.Biochemistry (Mosc)2009 JulPatra S-
25785838Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction.PLoS One2015 Mar 18Kawada Mdoi: 10.1371/journal.pone.0119415
27878251Glyceraldehyde-3-phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression.Int J Oncol2017 JanLiu Kdoi: 10.3892/ijo.2016.3774

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr126536504Missense_MutationnovelI14V0.13
BLCAchr1265382233'UTRnovel0.29
BLCAchr126537949SilentnovelA297A0.17
BLCAchr126537950Missense_MutationnovelG298W0.14
BLCAchr126536584SilentnovelL40L0.04
BLCAchr126537214Missense_MutationnovelI147M0.39
BLCAchr126536717Missense_MutationnovelK55E0.07
BLCAchr126536909Intronnovel0.08
BRCAchr126537608Missense_MutationnovelT184A0.33
BRCAchr126537716Missense_MutationNAV220L0.33
BRCAchr1265381763'UTRrs32115920.45
CESCchr126537657Missense_MutationNAR200L0.28
CESCchr126536957Missense_MutationNAA92T0.09
CESCchr1265348145'UTRnovel0.2
COADchr126536563SilentnovelI33I0.37
COADchr126536989Missense_MutationnovelF102L0.11
COADchr1265381903'UTRnovel0.9
COADchr126536911Intronnovel0.38
COADchr126537112Frame_Shift_DelNAG115Efs*210.14
ESCAchr126537112Frame_Shift_DelNAG115Efs*210.26
ESCAchr126536726Missense_MutationnovelG58S0.16
GBMchr126536991Missense_MutationnovelT103S0.41
GBMchr126536865Intronnovel0.37
GBMchr126536792Splice_SitenovelX79_splice0.42
GBMchr126537932Missense_MutationNAS292A0.34
HNSCchr126537342SilentnovelP159P0.29
HNSCchr126537211SilentnovelI146I0.14
HNSCchr126537725Missense_MutationnovelE223K0.13
HNSCchr126537679SilentnovelI207I0.47
KIRPchr126537312Frame_Shift_DelnovelN149Kfs*150.24
LIHCchr1265345295'UTRnovel1
LUADchr126537855Missense_Mutationrs11549316S266L0.1
LUADchr126536974Missense_MutationnovelE97D0.1
LUADchr126537967Silentrs138528853L303L0.32
LUADchr126537850Frame_Shift_DelnovelS266Pfs*1000.08
LUSCchr126537613Missense_MutationNAQ185H0.32
LUSCchr126536741Missense_MutationNAE63K0.41
LUSCchr126537752Missense_MutationnovelA232T0.08
LUSCchr126538137SilentnovelV325V0.29
OVchr126537376Missense_MutationNAV171L0.18
PRADchr126536594Splice_SitenovelX43_splice0.39
SARCchr126538151Missense_MutationnovelH330P0.22
SKCMchr126536507Missense_MutationnovelG15R0.31
SKCMchr126536508Missense_MutationnovelG15E0.3
SKCMchr1265381763'UTRrs32115920.54
SKCMchr126534841SilentnovelK3K0.09
SKCMchr126534842Missense_Mutationrs367765818V4M0.09
SKCMchr126537293Intronnovel0.11
SKCMchr126537117Missense_MutationNAG115E0.38
SKCMchr126538101Nonsense_MutationNAW313*0.32
SKCMchr126537115Silentrs763523311G114G0.42
STADchr126537770Missense_MutationnovelA238S0.15
STADchr126536914Splice_Regionnovel0.36
STADchr126537689Missense_MutationnovelT211A0.27
STADchr126537977Frame_Shift_DelnovelV308Lfs*30.55
STADchr126537840Missense_MutationNAV261A0.26
UCECchr126536595Splice_SitenovelX43_splice0.39
UCECchr126537661SilentnovelG201G0.42
UCECchr126537193Nonsense_MutationnovelY140*0.1
UCECchr126537907SilentnovelS283S0.4
UCECchr126536949Missense_MutationNAD89G0.58
UCECchr1265382193'UTRrs5597129470.11
UCECchr126536921Nonsense_Mutationrs755829002R80*0.17
UCECchr126536510Missense_Mutationrs758911385R16C0.32
UCECchr126536889Intronnovel0.35
UCECchr126537945Missense_MutationnovelD296G0.06
UCECchr126537940SilentNAT294T0.2
UCECchr126536788Splice_RegionnovelQ78Q0.14
UCECchr126537003Missense_MutationnovelK107R0.12
UCECchr126536966Missense_Mutationrs371192512V95I0.18
UCECchr1265381953'UTRrs7702805040.43
UCSchr126536935Missense_MutationnovelK84N0.47

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.10420.11856
MESODEL0.08050.17495
PAADDEL0.1250.0019175
TGCTAMP0.94673.5918e-21
THYMAMP0.03250.24554

Survival Analysis
CancerP-value Q-value
KIRC0.00047

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

ACC0.046

Kaplan-Meier Survival Analysis

HNSC0.00037

Kaplan-Meier Survival Analysis

SKCM0.048

Kaplan-Meier Survival Analysis

KIRP0.00018

Kaplan-Meier Survival Analysis

PAAD0.014

Kaplan-Meier Survival Analysis

BLCA0.012

Kaplan-Meier Survival Analysis

CESC0.0066

Kaplan-Meier Survival Analysis

KICH0.0042

Kaplan-Meier Survival Analysis

GBM0.032

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

LGG0.00021

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000111640 (Gene tree)
Gene ID
2597
Gene Symbol
GAPDH
Alias
GAPD
Full Name
glyceraldehyde-3-phosphate dehydrogenase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
4,449 bases
Position
chr12:6,533,927-6,538,375
Accession
4141
RBP type
non-canonical RBP
Summary
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
19650766Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions.Biochem J2009 Sep 25Hwang NRdoi: 10.1042/BJ20090854.
10964654Identification of the NAD(+)-binding fold of glyceraldehyde-3-phosphate dehydrogenase as a novel RNA-binding domain.Biochem Biophys Res Commun2000 Aug 28Nagy E-
7626640Uracil DNA-glycosylase/glyceraldehyde-3-phosphate dehydrogenase is an Ap4A binding protein.Biochemistry1995 Aug 1Baxi MD-
26564736The sweet side of RNA regulation: glyceraldehyde-3-phosphate dehydrogenase as a noncanonical RNA-binding protein.Wiley Interdiscip Rev RNA2016 Jan-FebWhite MRdoi: 10.1002/wrna.1315
21236242Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in ccn2 mRNA.Biochem Biophys Res Commun2011 Feb 18Kondo Sdoi: 10.1016/j.bbrc.2011.01.034
15519297Mapping tissue-specific genes correlated with age-dependent changes in protein stability and function.Arch Biochem Biophys2004 Dec 1Wisser KC-
29574117GAPDH as a model non-canonical AU-rich RNA binding protein.Semin Cell Dev Biol2019 FebGarcin EDdoi: 10.1016/j.semcdb.2018.03.013
30209975Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy.Autophagy2019 JanYau WWdoi: 10.1080/15548627.2018.1511263
10814569Specific interaction between the hepatitis delta virus RNA and glyceraldehyde 3-phosphate dehydrogenase: an enhancement on ribozyme catalysis.Virology2000 May 25Lin SS-
19937810Selection of reference genes for real-time quantitative reverse transcription-polymerase chain reaction in hippocampal structure in a murine model of temporal lobe epilepsy with focal seizures.J Neurosci Res2010 AprPernot Fdoi: 10.1002/jnr.22282.
18460208Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue.BMC Mol Biol2008 May 6Coulson DTdoi: 10.1186/1471-2199-9-46.
22475447Validation of reference genes for ovarian tissue from capuchin monkeys (Cebus apella).Zygote2013 MayBrito ABdoi: 10.1017/S0967199411000748
22023793Reference gene validation for qPCR in rat carotid body during postnatal development.BMC Res Notes2011 Oct 24Kim Idoi: 10.1186/1756-0500-4-440.
25573171Identification of suitable reference genes for gene expression studies using quantitative polymerase chain reaction in lung cancer in vitro.Mol Med Rep2015 MayAli Hdoi: 10.3892/mmr.2015.3159
25288528Structural insights into RNA recognition properties of glyceraldehyde-3-phosphate dehydrogenase 3 from Saccharomyces cerevisiae.IUBMB Life2014 SepShen Hdoi: 10.1002/iub.1313
28677248Identification of suitable reference genes during the formation of chlamydospores in Clonostachys rosea 67-1.Microbiologyopen2017 OctZhang Jdoi: 10.1002/mbo3.505
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000466525GAPDH-2061720--- (aa)--
ENST00000396856GAPDH-2021266-ENSP00000380065260 (aa)-E7EUT5
ENST00000396861GAPDH-2051348-ENSP00000380070335 (aa)-P04406
ENST00000396859GAPDH-2041256-ENSP00000380068335 (aa)-P04406
ENST00000466588GAPDH-2071363--- (aa)--
ENST00000474249GAPDH-2081333--- (aa)--
ENST00000496049GAPDH-210390--- (aa)--
ENST00000492719GAPDH-209930--- (aa)--
ENST00000619601GAPDH-2111086-ENSP00000478864293 (aa)-P04406
ENST00000396858GAPDH-2031292-ENSP00000380067293 (aa)-P04406
ENST00000229239GAPDH-2011875-ENSP00000229239335 (aa)-P04406
Gene Model
Click here to download ENSG00000111640's gene model file
Pathways
Pathway IDPathway NameSource
hsa00010Glycolysis / GluconeogenesisKEGG
hsa01100Metabolic pathwaysKEGG
hsa01200Carbon metabolismKEGG
hsa01230Biosynthesis of amino acidsKEGG
hsa04066HIF-1 signaling pathwayKEGG
hsa05010Alzheimer diseaseKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111640's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000111640GAPDH9882.422WBGene00001684gpd-29975.000Caenorhabditis_elegans
ENSG00000111640GAPDH9880.078WBGene00001683gpd-19972.941Caenorhabditis_elegans
ENSG00000111640GAPDH9880.078WBGene00001686gpd-49972.941Caenorhabditis_elegans
ENSG00000111640GAPDH10094.539ENSMUSG00000057666Gapdh10093.929Mus_musculus
ENSG00000111640GAPDH9869.020YGR192CTDH39965.046Saccharomyces_cerevisiae
ENSG00000111640GAPDH9868.235YJR009CTDH29964.742Saccharomyces_cerevisiae
ENSG00000111640GAPDH9869.020YJL052WTDH19964.438Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000226microtubule cytoskeleton organization-ISSProcess
GO:0004365glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity21873635.IBAFunction
GO:0004365glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity-ISSFunction
GO:0004365glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity3170585.7030790.NASFunction
GO:0005515protein binding11724794.15628863.16169070.16799092.17540579.20029029.20392205.20849852.21044950.23348613.23355646.23823123.24658140.25417112.29128334.IPIFunction
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus-ISSComponent
GO:0005737cytoplasm11785981.24507776.IDAComponent
GO:0005737cytoplasm-ISSComponent
GO:0005811lipid droplet14741744.IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol24101517.IDAComponent
GO:0005829cytosol-ISSComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IDAComponent
GO:0006094gluconeogenesis-TASProcess
GO:0006096glycolytic process21873635.IBAProcess
GO:0008017microtubule binding-ISSFunction
GO:0010951negative regulation of endopeptidase activity22832495.IDAProcess
GO:0015630microtubule cytoskeleton-ISSComponent
GO:0016020membrane19946888.HDAComponent
GO:0016241regulation of macroautophagy26626483.TASProcess
GO:0017148negative regulation of translation23071094.IDAProcess
GO:0017148negative regulation of translation15479637.IMPProcess
GO:0019828aspartic-type endopeptidase inhibitor activity22832495.IDAFunction
GO:0031640killing of cells of other organism22832495.IDAProcess
GO:0031965nuclear membrane-IDAComponent
GO:0031982vesicle19190083.HDAComponent
GO:0035605peptidyl-cysteine S-nitrosylase activity-ISSFunction
GO:0035606peptidyl-cysteine S-trans-nitrosylation-ISSProcess
GO:0042802identical protein binding20392205.21988832.IPIFunction
GO:0043231intracellular membrane-bounded organelle-IDAComponent
GO:0048471perinuclear region of cytoplasm-IEAComponent
GO:0050661NADP binding-IEAFunction
GO:0050715positive regulation of cytokine secretion22832495.IDAProcess
GO:0050821protein stabilization-ISSProcess
GO:0050832defense response to fungus22832495.IDAProcess
GO:0051287NAD binding-IEAFunction
GO:0051402neuron apoptotic process-ISSProcess
GO:0051873killing by host of symbiont cells22832495.IDAProcess
GO:0052501positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction22832495.IDAProcess
GO:0061621canonical glycolysis-TASProcess
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide22832495.IDAProcess
GO:0070062extracellular exosome11487543.12519789.19056867.19199708.20458337.21362503.23533145.HDAComponent
GO:0071346cellular response to interferon-gamma15479637.IDAProcess
GO:0097452GAIT complex15479637.23071094.IDAComponent
GO:0097718disordered domain specific binding11785981.IPIFunction
GO:1990904ribonucleoprotein complex15479637.IDAComponent
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