EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr126563366SilentnovelS279S0.52
BLCAchr126561762Missense_MutationnovelG370A0.38
BLCAchr126563731Missense_MutationNAE191Q0.16
BLCAchr126566580Missense_MutationNAK63E0.44
BLCAchr126557539SilentnovelK631K0.11
BLCAchr126566232Nonsense_MutationNAE115*0.21
BLCAchr126567872Missense_Mutationrs763386179R16Q0.51
BLCAchr126557280Missense_MutationnovelA718T0.29
BLCAchr126561063SilentnovelL405L0.25
BLCAchr126566814In_Frame_InsnovelD37_E38insP0.14
BLCAchr126561762Missense_MutationNAG370E0.47
BLCAchr126561057SilentnovelK407K0.32
BLCAchr126560695Splice_Regionnovel0.14
BRCAchr126561926Missense_MutationnovelS342P0.08
BRCAchr126557101SilentNAP777P0.19
BRCAchr126563164Missense_MutationNAE299K0.39
BRCAchr126561762Missense_MutationNAG370E0.19
BRCAchr126563656Missense_MutationNAE216K0.12
BRCAchr1265569673'UTRnovel0.06
BRCAchr126557636Missense_MutationnovelS599Y0.06
CESCchr126560309Nonsense_MutationnovelW526delins*0.06
CESCchr126557373Missense_Mutationrs781331024E687K0.26
CESCchr126560726Missense_MutationnovelS470C0.2
CESCchr126560519SilentNAL496L0.3
COADchr126561712Missense_MutationNAR387W0.38
COADchr126563943SilentnovelL160L0.22
COADchr126561030Silentrs777701681D416D0.35
COADchr126563121Missense_Mutationrs185687202R313Q0.33
COADchr126560496Missense_MutationNAA504V0.09
COADchr126563104Missense_Mutationrs747540211T319P0.45
COADchr126560496Missense_MutationNAA504V0.34
COADchr126557444Missense_MutationnovelT663I0.17
COADchr126557204Missense_MutationnovelK743R0.09
COADchr126561704SilentnovelL389L0.21
COADchr126560224Nonsense_MutationNAR555*0.22
COADchr126557021Frame_Shift_InsnovelR804Mfs*130.37
COADchr1265569763'UTRrs3707691790.15
DLBCchr126563677Missense_MutationnovelG209S0.41
ESCAchr126560113Missense_Mutationrs765511648P592S0.08
GBMchr126563460Missense_MutationnovelG248E0.29
GBMchr126566135Missense_MutationNAD147A0.54
HNSCchr126561892Missense_MutationnovelV353A0.3
HNSCchr126557014Missense_MutationnovelN806K0.38
HNSCchr126557263SilentnovelT723T0.13
KIRCchr1265569053'UTRnovel0.24
KIRCchr126560961Frame_Shift_InsnovelH441Afs*360.29
KIRPchr126563634Frame_Shift_DelnovelP222Lfs*450.47
LIHCchr126563922Missense_Mutationrs555886597R167W0.32
LIHCchr126557195Missense_MutationnovelH746R0.39
LIHCchr126560274Missense_MutationnovelR538L0.17
LUADchr126560222SilentNAR555R0.15
LUADchr126561944Missense_MutationNAD336Y0.4
LUADchr126563674Missense_MutationNAL210V0.27
LUADchr126563100Missense_MutationnovelR320L0.31
LUSCchr126560178Missense_Mutationrs751715863Y570C0.1
LUSCchr126560944Missense_MutationnovelR445L0.41
LUSCchr126560747Missense_MutationnovelC463Y0.27
LUSCchr126557435Missense_MutationNAS666F0.12
LUSCchr126566558Missense_MutationnovelA70G0.58
LUSCchr126567872Missense_Mutationrs763386179R16Q0.09
LUSCchr126566786Missense_MutationNAA47V0.24
LUSCchr126567939Intronnovel0.34
LUSCchr126560122Missense_MutationnovelN589Y0.27
LUSCchr126560519SilentnovelL496L0.38
LUSCchr126560106Missense_MutationNAS594C0.14
MESOchr126557518Frame_Shift_DelnovelK638Nfs*130.36
OVchr126560319Frame_Shift_DelnovelE523Gfs*60.28
OVchr126560202Missense_MutationnovelS562T0.09
OVchr126566125SilentNAS150S0.85
OVchr126563906Missense_Mutationrs768153160R172Q0.27
OVchr126557136Nonsense_MutationnovelE766*0.05
OVchr126557456Nonsense_MutationNAS659*0.47
OVchr126561926Missense_MutationnovelS342P0.06
OVchr126557359Silentrs369192791E691E0.06
PAADchr126560987Missense_Mutationrs776267063R431W0.22
PAADchr126563412Missense_MutationnovelS264F0.43Methyltr_RsmB-F
PRADchr126560197Missense_Mutationrs770629626R564C0.07
PRADchr126557626SilentnovelA602A0.5
READchr126560948Missense_MutationNAG444R0.43
READchr126563911Missense_MutationNAK170N0.44
READchr126560513SilentnovelA498A0.17
READchr126563725Nonsense_MutationNAE193*0.39
SARCchr126561946Missense_MutationnovelL335Q0.23
SARCchr126566299SilentnovelK92K0.57
SKCMchr126560147Silentrs267603636F580F0.33
SKCMchr126557374Silentrs748372861A686A0.43
SKCMchr126557375Missense_MutationnovelA686V0.43
SKCMchr126566132Missense_MutationNAS148F0.38
SKCMchr126561735Missense_MutationNAA379V0.15
SKCMchr126560097Splice_SiteNAX597_splice0.57
SKCMchr126561744Missense_MutationnovelP376L0.36
SKCMchr126557103Missense_Mutationrs746289611P777S0.26
SKCMchr126557104SilentnovelT776T0.26
SKCMchr126566287SilentnovelS96S0.59
SKCMchr1265569673'UTRnovel0.5
SKCMchr126560536Nonsense_MutationnovelQ491*0.31
SKCMchr126560537SilentnovelL490L0.29
SKCMchr126560104Missense_MutationNAQ595K0.47
SKCMchr126557199Missense_MutationNAH745Y0.1
SKCMchr126557236SilentnovelS732S0.41
SKCMchr126563637Missense_Mutationrs749124800P222L0.23
SKCMchr126563638Missense_MutationnovelP222S0.24
SKCMchr126566567Missense_MutationNAS67F0.12
SKCMchr126560735Missense_MutationNAG467E0.12
SKCMchr126561959Missense_MutationnovelR331C0.45
STADchr126560986Missense_Mutationrs763509029R431Q0.27
STADchr1265569753'UTRnovel0.57
STADchr126560547Missense_MutationNAC487Y0.09
STADchr126563491Nonsense_MutationNAR238*0.35
STADchr126560974Missense_MutationNAT435I0.25
STADchr126566130Missense_MutationNAN149D0.37
STADchr126561051SilentNAT409T0.25
THYMchr126560777Frame_Shift_DelnovelG453Afs*230.32
UCECchr126560788Splice_SiteNAX450_splice0.23
UCECchr126560714Missense_MutationnovelA474V0.21
UCECchr126560753Missense_MutationnovelA461V0.52
UCECchr126561046Missense_MutationnovelV411A0.08
UCECchr126566273Missense_MutationnovelP101H0.75
UCECchr126560229Missense_Mutationrs201295423R553H0.35
UCECchr126560930Splice_SitenovelX449_splice0.41
UCECchr126566815Silentrs376138257D37D0.43
UCECchr126557471Missense_MutationNAS654Y0.24
UCECchr126560492SilentNAT505T0.12
UCECchr126563101Nonsense_MutationnovelR320*0.46
UCECchr126560154Missense_MutationnovelG578V0.43
UCECchr126557030Missense_MutationNAS801Y0.15
UCECchr126560945Missense_Mutationrs749232742R445C0.27
UCECchr126557253Missense_MutationNAT727A0.29
UCECchr126563095Nonsense_MutationnovelR322*0.16
UCECchr126563514Missense_Mutationrs776449166D230G0.27
UCECchr126566559Missense_MutationnovelA70T0.23
UCECchr126557101Frame_Shift_DelnovelK778Rfs*?0.39
UCECchr126557224SilentnovelT736T0.36
UCECchr126563379Missense_MutationnovelA275V0.15Methyltr_RsmB-F
UCECchr126563634Missense_Mutationrs748025996P223H0.36
UCECchr126563634Frame_Shift_DelnovelP223Lfs*450.06
UCECchr126567895SilentnovelT8T0.08
UCECchr126566271Nonsense_MutationnovelR102*0.32
UCECchr126566779Missense_MutationnovelK49N0.44
UCECchr126557030Missense_MutationnovelS801F0.5
UCECchr126567840Missense_MutationNAE27K0.19
UCECchr126560779SilentnovelG452G0.34
UCECchr126563366SilentnovelS279S0.3
UCSchr126557008Missense_MutationnovelQ808H0.53

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.10420.11856
MESODEL0.08050.17495
PAADDEL0.1250.0019175
TGCTAMP0.94673.5918e-21
THYMAMP0.03250.24554

Survival Analysis
CancerP-value Q-value
STAD0.011

Kaplan-Meier Survival Analysis

SARC0.0017

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

ACC0.00013

Kaplan-Meier Survival Analysis

UCS0.013

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

LUSC0.045

Kaplan-Meier Survival Analysis

BRCA0.044

Kaplan-Meier Survival Analysis

KIRP0.0034

Kaplan-Meier Survival Analysis

COAD0.011

Kaplan-Meier Survival Analysis

BLCA0.04

Kaplan-Meier Survival Analysis

READ0.044

Kaplan-Meier Survival Analysis

LIHC0.00016

Kaplan-Meier Survival Analysis

LGG0.00021

Kaplan-Meier Survival Analysis

LUAD0.00097

Kaplan-Meier Survival Analysis

UVM0.01

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000111641 (Gene tree)
Gene ID
4839
Gene Symbol
NOP2
Alias
NOP120|NSUN1|p120|NOL1
Full Name
NOP2 nucleolar protein
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
11,829 bases
Position
chr12:6,556,863-6,568,691
Accession
7867
RBP type
canonical RBP
Summary
(NOP2 Nucleolar Protein) is a Protein Coding gene. Diseases associated with NOP2 include Kabuki Syndrome 1. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is NSUN5.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000439422Methyltr_RsmB-FPF01189.173.3e-8311
ENSP00000484384Methyltr_RsmB-FPF01189.173.3e-8311
ENSP00000382392Methyltr_RsmB-FPF01189.174.7e-8311
ENSP00000443150Methyltr_RsmB-FPF01189.174.7e-8311
ENSP00000313272Methyltr_RsmB-FPF01189.174.8e-8311
ENSP00000444437Methyltr_RsmB-FPF01189.174.8e-8311
ENSP00000371858Methyltr_RsmB-FPF01189.175.2e-8311
ENSP00000479320Methyltr_RsmB-FPF01189.175.2e-8311
ENSP00000440754Methyltr_RsmB-FPF01189.171.6e-0611
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
9531475Nucleolar protein p120 contains an arginine-rich domain that binds to ribosomal RNA.Biochem J1998 Apr 15Gustafson WC-
25043274Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2.Hepatology2014 OctWang Fdoi: 10.1002/hep.27239
16641140p120 nucleolar-proliferating antigen is a direct target of G-CSF signaling during myeloid differentiation.J Leukoc Biol2006 MayKhanna-Gupta A-
26906424Telomerase activates transcription of cyclin D1 gene through an interaction with NOL1.J Cell Sci2016 Apr 15Hong Jdoi: 10.1242/jcs.181040
8768786Functional domains of nucleolar phosphoprotein p120.Physiol Chem Phys Med NMR1995Durban E-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000545492NOP2-219657-ENSP00000441923159 (aa)-F5GWB7
ENST00000382421NOP2-2022736-ENSP00000371858845 (aa)-P46087
ENST00000400580NOP2-204561--- (aa)--
ENST00000542015NOP2-2131002--- (aa)--
ENST00000542919NOP2-215894--- (aa)--
ENST00000538420NOP2-209572-ENSP0000044358598 (aa)-F5H8G6
ENST00000542944NOP2-2161080-ENSP00000440754275 (aa)-F5GYR3
ENST00000399466NOP2-2032701-ENSP00000382392808 (aa)-P46087
ENST00000536124NOP2-205689-ENSP00000442895176 (aa)-F5H709
ENST00000544630NOP2-217657--- (aa)--
ENST00000617555NOP2-2222017-ENSP00000484384628 (aa)-P46087
ENST00000620535NOP2-2232791-ENSP00000479320845 (aa)-P46087
ENST00000545200NOP2-2182751-ENSP00000439422628 (aa)-P46087
ENST00000541778NOP2-2123038-ENSP00000443150808 (aa)-P46087
ENST00000546053NOP2-221508--- (aa)--
ENST00000322166NOP2-2012683XM_005253691ENSP00000313272812 (aa)XP_005253748P46087
ENST00000545915NOP2-220630-ENSP0000044274281 (aa)-F5H359
ENST00000542867NOP2-214848-ENSP00000443035250 (aa)-F5H5X6
ENST00000538697NOP2-210569--- (aa)--
ENST00000540228NOP2-211668-ENSP0000044540281 (aa)-F5H359
ENST00000537708NOP2-208598--- (aa)--
ENST00000536506NOP2-206889--- (aa)--
ENST00000537442NOP2-2072613-ENSP00000444437812 (aa)-P46087
Gene Model
Click here to download ENSG00000111641's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111641's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000111641NOP28862.963ENSAOCG00000006545NOP26369.510Amphiprion_ocellaris
ENSG00000111641NOP29559.470ENSATEG00000021636NOP28359.906Anabas_testudineus
ENSG00000111641NOP210093.141ENSANAG00000026027NOP210091.411Aotus_nancymaae
ENSG00000111641NOP27175.907ENSACLG00000023702NOP28258.129Astatotilapia_calliptera
ENSG00000111641NOP210093.478ENSCJAG00000008179NOP210092.383Callithrix_jacchus
ENSG00000111641NOP210094.565ENSCCAG00000037712NOP210092.506Cebus_capucinus
ENSG00000111641NOP29996.350ENSCATG00000006182NOP210094.834Cercocebus_atys
ENSG00000111641NOP29759.630ENSGAFG00000014153NOP26970.526Gambusia_affinis
ENSG00000111641NOP29461.481ENSKMAG00000007111NOP28261.637Kryptolebias_marmoratus
ENSG00000111641NOP210096.000ENSMFAG00000004333NOP210095.548Macaca_fascicularis
ENSG00000111641NOP210096.000ENSMMUG00000018683NOP210095.390Macaca_mulatta
ENSG00000111641NOP210096.000ENSMNEG00000034027NOP210095.548Macaca_nemestrina
ENSG00000111641NOP210096.000ENSMLEG00000043675NOP210094.588Mandrillus_leucophaeus
ENSG00000111641NOP29560.150ENSMMOG00000016086NOP27668.033Mola_mola
ENSG00000111641NOP29659.398ENSMALG00000022478NOP28359.486Monopterus_albus
ENSG00000111641NOP29460.568ENSORLG00000012153-8360.870Oryzias_latipes
ENSG00000111641NOP29459.328ENSORLG00015011510-8361.085Oryzias_latipes_hsok
ENSG00000111641NOP29888.608ENSOGAG00000010028NOP210081.871Otolemur_garnettii
ENSG00000111641NOP210099.363ENSPPAG00000030215NOP210099.363Pan_paniscus
ENSG00000111641NOP210099.363ENSPTRG00000004579NOP210099.363Pan_troglodytes
ENSG00000111641NOP29463.756ENSPKIG00000025311NOP28166.218Paramormyrops_kingsleyae
ENSG00000111641NOP29458.801ENSPMGG00000019923NOP28256.381Periophthalmus_magnuspinnatus
ENSG00000111641NOP29990.123ENSPCOG00000002562NOP210087.179Propithecus_coquereli
ENSG00000111641NOP29996.296ENSRBIG00000044511NOP210095.548Rhinopithecus_bieti
ENSG00000111641NOP29559.542ENSSDUG00000011360NOP28359.513Seriola_dumerili
ENSG00000111641NOP29559.398ENSSLDG00000023452NOP28059.777Seriola_lalandi_dorsalis
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000027ribosomal large subunit assembly24120868.IMPProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding12080348.25416956.IPIFunction
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus16791210.HDAComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005730nucleolus-IDAComponent
GO:0006357regulation of transcription by RNA polymerase II-TASProcess
GO:0008284positive regulation of cell proliferation1394192.IDAProcess
GO:0009383rRNA (cytosine-C5-)-methyltransferase activity21873635.IBAFunction
GO:0070475rRNA base methylation21873635.IBAProcess
GO:1901796regulation of signal transduction by p53 class mediator24120868.IMPProcess
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