EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26829751MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.Nat Genet2016 MarBandopadhayay Pdoi: 10.1038/ng.3500
27358073MiR-143-3p functions as a tumor suppressor by regulating cell proliferation, invasion and epithelial-mesenchymal transition by targeting QKI-5 in esophageal squamous cell carcinoma.Mol Cancer2016 Jun 29He Zdoi: 10.1186/s12943-016-0533-3.
25420938MicroRNA-155 promotes the proliferation and invasion abilities of colon cancer cells by targeting quaking.Mol Med Rep2015 MarHe Bdoi: 10.3892/mmr.2014.2994
24153116The tumor suppressing effects of QKI-5 in prostate cancer: a novel diagnostic and prognostic protein.Cancer Biol Ther2014 JanZhao Ydoi: 10.4161/cbt.26722
24722255The RNA-binding protein QKI suppresses cancer-associated aberrant splicing.PLoS Genet2014 Apr 10Zong FYdoi: 10.1371/journal.pgen.1004289
24918581QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2.Cancer Biol Ther2014 SepLu Wdoi: 10.4161/cbt.29502
23440637Preparation and characterizations of polyclonal antibodies against STAR protein QKI7b.Appl Biochem Biotechnol2013 AprLiu Qdoi: 10.1007/s12010-012-0081-2
27555542A large-scale analysis of alternative splicing reveals a key role of QKI in lung cancer.Mol Oncol2016 Novde Miguel FJdoi: 10.1016/j.molonc.2016.08.001
27092877QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis.Oncotarget2016 May 31Li Fdoi: 10.18632/oncotarget.8739.
29871889miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking.EMBO J2018 Jul 2Pillman KAdoi: 10.15252/embj.201899016

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr6163563689Missense_MutationnovelE302Q0.49
BLCAchr6163563622Silentrs569768147P279P0.18
BLCAchr6163563778Intronnovel0.42
BLCAchr6163478811Missense_MutationNAR106T0.17KH_1
BLCAchr6163566741SilentnovelR319R0.09
BLCAchr6163563745Intronnovel0.14
BLCAchr6163563646In_Frame_DelnovelY288del0.22
BLCAchr6163562008SilentnovelK191K0.44
BRCAchr6163566719Splice_SitenovelX312_splice0.71
BRCAchr6163566206Intronnovel1
BRCAchr6163563551Missense_MutationNAR256G0.34
CESCchr6163568771Intronnovel0.37
CESCchr6163566663Intronrs3722179720.43
CESCchr6163568611Intronnovel0.5
CESCchr6163569222Intronnovel0.28
CESCchr6163564600Intronnovel0.39
CESCchr6163566156Intronnovel0.77
CESCchr6163569099Intronnovel0.19
CESCchr6163564655Intronrs7461045080.32
CHOLchr61635708643'UTRnovel0.66
COADchr6163566663Intronrs3722179720.11
COADchr6163566861Intronnovel0.31
COADchr6163455388SilentNAE84E0.47
COADchr6163561988Nonsense_MutationNAG185*0.27
COADchr6163563674Missense_MutationNAA297T0.31
COADchr6163564689IntronNA0.31
COADchr6163566713Splice_RegionNA0.46
COADchr6163563425Missense_MutationnovelL214F0.16
COADchr6163564655Intronrs7461045080.46
COADchr6163565814Intronnovel0.47
COADchr6163535062Missense_MutationNAQ161H0.06
COADchr6163565940Intronnovel0.07
COADchr6163566724Missense_MutationNAA313V0.19
COADchr6163562015SilentNAL194L0.48
COADchr6163566669Intronnovel0.27
COADchr6163566669Intronnovel0.17
COADchr6163564600Intronnovel0.47
COADchr6163566669Intronnovel0.23
COADchr6163566663Intronrs3722179720.13
COADchr6163566900Intronnovel0.43
COADchr6163566592Intronnovel0.27
COADchr6163566663Intronrs3722179720.28
COADchr6163566970Intronnovel0.1
COADchr6163566663Intronrs3722179720.28
COADchr6163566663Intronrs3722179720.38
COADchr6163566901Intronnovel0.37
COADchr6163566663Intronrs3722179720.37
COADchr6163564894Intronnovel0.39
COADchr6163563788Intronnovel0.43
COADchr6163566044Intronnovel0.48
COADchr6163455365Nonsense_MutationNAG77*0.15
COADchr6163562071Splice_SiteNAX212_splice0.18
COADchr6163566742Missense_Mutationrs777858938R319Q0.2
COADchr6163566775Missense_Mutationrs779943694R330K0.16
COADchr6163455410Nonsense_MutationNAE92*0.31
COADchr6163564820Intronnovel0.58
COADchr6163566852Intronnovel0.38
COADchr6163565837Intronnovel0.31
COADchr6163415286SilentnovelL31L0.47
COADchr6163566663Intronrs3722179720.23
COADchr6163566120Intronnovel0.32
COADchr6163566049Intronnovel0.44
COADchr6163566663Intronrs3722179720.33
COADchr6163566663Intronrs3722179720.44
COADchr6163566901Intronnovel0.32
COADchr6163563839Intronrs7796145350.33
COADchr6163563682SilentNAS299S0.15
ESCAchr6163566662Intronnovel0.24
ESCAchr6163568670Intronnovel0.37
ESCAchr61635708413'UTRnovel0.15
ESCAchr6163563580Silentrs769837755N265N0.21
ESCAchr6163567530Intronnovel0.33
ESCAchr6163566339Intronnovel0.35
ESCAchr6163570094Intronnovel0.25
ESCAchr6163569872Intronnovel0.29
ESCAchr6163566663Intronrs3722179720.8
ESCAchr6163569149Intronnovel0.35
ESCAchr6163534979Splice_Regionnovel0.16
ESCAchr6163415301SilentnovelG36G0.27
ESCAchr6163564561Intronnovel0.5
GBMchr6163564592Intronnovel0.3
GBMchr6163563720Splice_SitenovelX312_splice0.41
GBMchr6163564864Intronnovel0.34
GBMchr6163415209Missense_MutationnovelE6K0.33
GBMchr6163562071Splice_SiteNAX212_splice0.37
GBMchr6163563550Frame_Shift_DelnovelR256Kfs*180.48
GBMchr6163563606Missense_MutationnovelI274R0.2
GBMchr6163535121Missense_MutationNAP181R0.13
GBMchr6163478829Missense_MutationNAQ112P0.41KH_1
GBMchr6163478789Frame_Shift_DelnovelV99Lfs*310.35KH_1
HNSCchr6163535107Missense_Mutationrs765523224K176N0.22
HNSCchr6163563509Missense_MutationnovelR242C0.22
HNSCchr6163563689Missense_MutationnovelE302Q0.24
HNSCchr61635708083'UTRnovel0.23
HNSCchr6163570708Nonstop_Mutationnovel*342Qext*50.24
HNSCchr6163563437Missense_MutationnovelL218V0.12
HNSCchr6163565889Intronnovel0.26
HNSCchr6163455410Missense_MutationnovelE92Q0.3
KIRCchr6163566663Intronrs3722179720.38
KIRCchr6163564654Intronnovel0.28
KIRCchr6163564845Intronnovel0.33
KIRCchr6163564846Intronnovel0.33
KIRPchr6163566682Intronnovel0.37
LGGchr6163566000Intronnovel0.35
LGGchr6163563444Missense_MutationNAA220G0.14
LIHCchr6163563864Intronnovel0.57
LIHCchr6163563571SilentnovelV262V0.74
LUADchr6163535113Silentrs373262109L178L0.23
LUADchr6163562048Missense_MutationNAR205G0.4
LUADchr6163455356Missense_MutationnovelD74Y0.21
LUADchr61635707813'UTRnovel0.13
LUADchr61634151805'UTRnovel0.21
LUADchr6163564636Intronrs3769256140.52
LUADchr6163562020Missense_MutationnovelM195I0.4
LUADchr6163563617Missense_MutationnovelG278W0.11
LUADchr6163535088Missense_MutationnovelR170K0.06
LUADchr6163535020Silentrs758398699L147L0.12
LUADchr61635707123'UTRnovel0.48
LUADchr6163566674Intronnovel0.14
LUSCchr6163478857SilentNAI121I0.2
LUSCchr6163415233Missense_MutationNAT14S0.11
LUSCchr6163563566Missense_Mutationrs752167117A261T0.15
LUSCchr6163455332Nonsense_MutationnovelE66*0.23
LUSCchr6163564604Intronnovel0.54
LUSCchr6163535057Missense_MutationnovelA160P0.79
LUSCchr6163564670Intronnovel0.12
LUSCchr61635708363'UTRnovel0.16
LUSCchr6163566866Intronnovel0.5
LUSCchr6163564721Intronnovel0.31
LUSCchr6163535044SilentNAI155I0.09
LUSCchr6163564847Intronnovel0.27
LUSCchr6163478805Missense_MutationnovelG104V0.16KH_1
OVchr6163563445SilentnovelA220A0.09
OVchr6163563595SilentNAP270P0.38
PAADchr6163566756Missense_MutationNAR324C0.05
PAADchr6163415286SilentnovelL31L0.17
PRADchr6163562037Missense_MutationNAN201S0.3
PRADchr6163478897Splice_SiteNAX134_splice0.2
PRADchr61635707353'UTRnovel0.14
PRADchr6163566061Intronnovel0.17
READchr6163564767Intronnovel0.26
READchr6163565962IntronNA0.28
READchr6163566725Silentrs765276688A313A0.53
READchr6163563510Missense_Mutationrs142647102R242H0.6
READchr6163566786Missense_MutationNAA334T0.32
READchr6163455295SilentnovelR53R0.38
READchr6163564503Intronnovel0.36
READchr6163564885Intronnovel0.4
READchr6163535005Silentrs748022503P142P0.05
READchr6163564772Intronnovel0.44
READchr6163566624Intronnovel0.4
SARCchr6163563458Missense_Mutationrs772401666A225P0.24
SARCchr6163565902Intronnovel0.16
SARCchr6163568826Intronnovel0.49
SARCchr6163568765Intronnovel0.14
SKCMchr61635708403'UTRnovel0.65
SKCMchr6163566741Nonsense_MutationNAR319*0.25
SKCMchr6163564788Intronnovel0.71
SKCMchr6163564789IntronNA0.71
SKCMchr6163415196Translation_Start_SiteNAM1?0.34
SKCMchr6163455397Nonsense_MutationNAY87*0.21
SKCMchr6163535018SilentNAL147L0.46
SKCMchr6163455365Missense_MutationnovelG77R0.69
SKCMchr6163563633Nonsense_MutationNAL283*0.46
STADchr6163478888Frame_Shift_Delrs755727862K134Rfs*140.39
STADchr6163455391Missense_MutationnovelK85N0.18
STADchr6163566049Intronnovel0.16
STADchr6163566669Intronnovel0.22
STADchr6163565952Intronnovel0.1
STADchr6163415196Translation_Start_SiteNAM1?0.17
STADchr6163563485Missense_Mutationrs773954748P234S0.29
STADchr6163566663Intronrs3722179720.17
STADchr6163478888Frame_Shift_Delrs755727862K134Rfs*140.84
STADchr6163563535Silentrs778641586T250T0.17
STADchr6163566663Intronrs3722179720.21
STADchr6163564655Intronrs7461045080.37
STADchr6163455277Splice_SitenovelX48_splice0.42
STADchr6163566044Intronnovel0.13
STADchr61635708413'UTRnovel0.13
STADchr61635707673'UTRnovel0.2
STADchr6163415197Missense_MutationnovelV2F0.1
STADchr61635708953'UTRnovel0.54
STADchr6163478887Frame_Shift_Insrs766110096E135Gfs*50.44
STADchr6163535069Missense_MutationNAA164T0.16
STADchr6163563423Missense_MutationNAA213G0.21
STADchr6163566663Intronrs3722179720.57
STADchr6163566756Missense_MutationNAR324C0.29
STADchr6163563484Silentrs764441206A233A0.29
STADchr6163478809SilentnovelP105P0.19
STADchr6163566663Intronrs3722179720.17
STADchr6163564655Intronrs7461045080.3
STADchr6163563687Missense_MutationNAL301R0.05
STADchr6163563510Missense_Mutationrs142647102R242H0.19
STADchr6163566049Intronnovel0.43
UCECchr6163564655Intronrs7461045080.48
UCECchr6163564894Intronnovel0.55
UCECchr6163565919Intronnovel0.38
UCECchr6163566663Intronrs3722179720.31
UCECchr6163563509Missense_MutationnovelR242C0.08
UCECchr6163566215Intronnovel0.38
UCECchr6163566355Intronnovel0.29
UCECchr6163566077Intronnovel0.39
UCECchr6163563487SilentnovelP234P0.21
UCECchr6163563698Missense_Mutationrs752418524I305V0.43
UCECchr6163566663Intronrs3722179720.32
UCECchr6163569482Intronnovel0.48
UCECchr6163564544Intronnovel0.45
UCECchr6163566663Intronrs3722179720.53
UCECchr6163478888Frame_Shift_Delrs755727862K134Rfs*140.33
UCECchr6163478888Frame_Shift_Delrs755727862K134Rfs*140.51
UCECchr6163564879Intronnovel0.2
UCECchr6163566901Intronnovel0.4
UCECchr6163566481Intronnovel0.13
UCECchr6163455293Missense_MutationNAR53W0.27
UCECchr6163566833Intronrs3736181290.19
UCECchr6163568960Intronnovel0.22
UCECchr6163478888Frame_Shift_Delrs755727862K134Rfs*140.28
UCECchr6163564655Intronrs7461045080.36
UCECchr6163455410Nonsense_MutationNAE92*0.11
UCECchr6163478845Silentrs151172419T117T0.13
UCECchr6163565882Intronnovel0.22
UCECchr6163569251Intronnovel0.38
UCECchr6163565933Intronnovel0.34
UCECchr61635708363'UTRnovel0.33
UCECchr6163566663Intronrs3722179720.49
UCECchr6163566658Intronnovel0.4
UCECchr6163568176IntronNA1
UCECchr6163568187Intronnovel0.5
UCECchr6163568655Intronnovel0.25
UCECchr6163570084Intronnovel0.09
UCECchr61635708353'UTRnovel0.32
UCECchr6163569751Intronnovel0.1
UCECchr6163566663Intronrs3722179720.29
UCECchr6163478888Frame_Shift_Delrs755727862K134Rfs*140.44
UCECchr6163566663Intronrs3722179720.39
UCECchr6163566663Intronrs3722179720.25
UCECchr6163569068Intronnovel0.36
UCECchr6163566663Intronrs3722179720.63
UCECchr6163567368Intronrs5590624010.18
UCECchr6163535099Missense_MutationNAE174K0.28
UCECchr6163455318Frame_Shift_InsnovelN62Kfs*130.74
UCECchr6163568246Intronrs3689469580.43
UCECchr6163570060Intronrs3707804590.28
UCECchr6163564655Intronrs7461045080.43
UCECchr6163566663Intronrs3722179720.4
UCECchr6163568960Intronnovel0.64
UCECchr61635707273'UTRnovel0.1
UCECchr6163567466Intronnovel0.48
UCECchr6163566663Intronrs3722179720.63
UCECchr6163563581Missense_MutationNAG266R0.33
UCECchr6163564894Intronnovel0.35
UCECchr6163415203Missense_MutationnovelE4K0.62
UCECchr6163567173Intronnovel0.42
UCECchr6163567388Intronnovel0.41
UCECchr6163568618Intronnovel0.38
UCECchr6163566663Intronrs3722179720.37
UCECchr6163566669Intronnovel0.31
UCECchr61635708363'UTRnovel0.35
UCECchr61635710063'UTRnovel0.83
UCECchr6163566663Intronrs3722179720.16
UCECchr6163568959Intronnovel0.63
UCECchr6163569044Intronnovel0.29
UCECchr6163569470Intronnovel0.16
UCECchr6163565997Intronnovel0.28
UCECchr6163566555Intronrs7523233900.2
UCECchr6163566714Splice_Regionnovel0.37
UCECchr6163568476Intronnovel0.14
UCECchr6163569462Intronnovel0.21
UCECchr6163569948Intronnovel0.13
UCECchr6163478888Frame_Shift_Delrs755727862K134Rfs*140.42
UCECchr6163566909Intronnovel0.3
UCECchr6163563469SilentnovelI228I0.13
UCECchr6163568536Intronrs7520258010.59
UCECchr6163567401Intronnovel0.45
UCECchr6163568246Intronrs3689469580.5
UCECchr6163478796Missense_MutationnovelR101I0.45KH_1
UCECchr6163563565Silentrs750076096T260T0.33
UCECchr6163569669Intronnovel0.45
UCECchr6163570063Intronnovel0.34
UCECchr6163564655Intronrs7461045080.38
UCECchr6163564599Intronrs3731511550.45
UCECchr6163567258Intronnovel0.47
UCECchr6163565906Intronrs7538973390.44
UCECchr6163566663Intronrs3722179720.5
UCECchr6163569400Intronnovel0.5
UCECchr6163563435Missense_MutationNAS217Y0.33
UCECchr6163563727Splice_Regionnovel0.2
UCECchr6163568471Intronnovel0.18
UCECchr6163566062Intronnovel0.38
UCECchr6163567071Intronnovel0.38
UCECchr6163568435Intronnovel0.4
UCECchr6163563565Silentrs750076096T260T0.46
UCECchr6163566663Intronrs3722179720.35
UCECchr6163565956Intronnovel0.43
UCECchr6163566663Intronrs3722179720.32
UCECchr6163566533Intronnovel0.46
UCECchr6163566663Intronrs3722179720.49
UCECchr6163566898Intronnovel0.33
UCECchr6163569821Intronnovel0.53
UCECchr6163566663Intronrs3722179720.27
UCECchr6163566043Intronnovel0.39
UCECchr6163566663Intronrs3722179720.15
UCECchr6163564655Intronrs7461045080.46
UCECchr6163566663Intronrs3722179720.08
UCECchr6163566669Intronnovel0.38
UCECchr6163564501Intronnovel0.16
UCECchr6163564633Intronrs3767054440.32
UCECchr6163567173Intronnovel0.41
UCECchr6163566903Intronnovel0.45
UCECchr6163534991Missense_MutationnovelN138H0.22
UCECchr6163563922Intronnovel0.18
UCECchr6163565681Intronnovel0.54
UCECchr6163455410Nonsense_MutationNAE92*0.44
UCECchr6163569963Intronnovel0.38
UCECchr6163567252Intronnovel0.39
UCECchr6163478888Frame_Shift_Delrs755727862K134Rfs*140.38
UCECchr6163478888Frame_Shift_Delrs755727862K134Rfs*140.33
UCECchr6163564655Intronnovel0.37
UCECchr6163563626Missense_MutationnovelA281T0.33
UCECchr6163564588Intronnovel0.33
UCECchr6163566127Intronnovel0.37
UCECchr6163566371Intronnovel0.4
UCECchr6163567371Intronnovel0.37
UCECchr6163568792Intronnovel0.27
UCECchr6163563749Intronnovel0.37
UCECchr61635708373'UTRnovel0.34
UCECchr6163478887Frame_Shift_Insrs766110096E135Gfs*50.39
UVMchr6163478898Splice_SitenovelX134_splice0.14

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.21110.041315
BLCADEL0.37990.00027473
CESCDEL0.28819.8477e-05
GBMDEL0.28254.6566e-34
KIRCDEL0.24627.439e-11
KIRPDEL0.10760.054498
LGGDEL0.1540.0022414
MESODEL0.35630.0023534
PAADDEL0.38040.11274
SKCMDEL0.54771.5442e-06
TGCTDEL0.09330.0031874
THYMDEL0.13010.10691

Survival Analysis
CancerP-value Q-value
KIRC0.0045

Kaplan-Meier Survival Analysis

STAD0.002

Kaplan-Meier Survival Analysis

SKCM0.00058

Kaplan-Meier Survival Analysis

KIRP0.012

Kaplan-Meier Survival Analysis

UCEC0.011

Kaplan-Meier Survival Analysis

LIHC0.0096

Kaplan-Meier Survival Analysis

LGG0.035

Kaplan-Meier Survival Analysis

LUAD0.025

Kaplan-Meier Survival Analysis

OV0.023

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000112531 (Gene tree)
Gene ID
9444
Gene Symbol
QKI
Alias
QK3
Full Name
QKI, KH domain containing RNA binding
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
164,597 bases
Position
chr6:163,414,000-163,578,596
Accession
21100
RBP type
canonical RBP
Summary
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000443690KH_1PF00013.292.6e-0611
ENSP00000440991KH_1PF00013.294.4e-0611
ENSP00000440599KH_1PF00013.295.1e-0611
ENSP00000408382KH_1PF00013.291.5e-0511
ENSP00000375973KH_1PF00013.291.5e-0511
ENSP00000408775KH_1PF00013.291.5e-0511
ENSP00000354867KH_1PF00013.291.6e-0511
ENSP00000275262KH_1PF00013.291.6e-0511
ENSP00000355094KH_1PF00013.291.7e-0511
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
16641098Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia.Proc Natl Acad Sci U S A2006 May 9Aberg K-
19517016The QKI-6 and QKI-7 RNA binding proteins block proliferation and promote Schwann cell myelination.PLoS One2009 Jun 11Larocque Ddoi: 10.1371/journal.pone.0005867.
20927331QKI-7 regulates expression of interferon-related genes in human astrocyte glioma cells.PLoS One2010 Sep 29Jiang Ldoi: 10.1371/journal.pone.0013079.
29663385Quaking promotes the odontoblastic differentiation of human dental pulp stem cells.J Cell Physiol2018 SepLi Sdoi: 10.1002/jcp.26561
12682013Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism.EMBO J2003 Apr 15Zhang Y-
29944885Circ-UBR5: An exonic circular RNA and novel small nuclear RNA involved in RNA splicing.Biochem Biophys Res Commun2018 Sep 5Qin Mdoi: 10.1016/j.bbrc.2018.06.112
10506177The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm.J Biol Chem1999 Oct 8Wu J-
16041388Target RNA motif and target mRNAs of the Quaking STAR protein.Nat Struct Mol Biol2005 AugGalarneau A-
19457263The STAR RNA binding proteins GLD-1, QKI, SAM68 and SLM-2 bind bipartite RNA motifs.BMC Mol Biol2009 May 20Galarneau Adoi: 10.1186/1471-2199-10-47.
22751500STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA.Genes Dev2012 Jul 1Chen AJdoi: 10.1101/gad.189001.112.
23319046The QKI-5 and QKI-6 RNA binding proteins regulate the expression of microRNA 7 in glial cells.Mol Cell Biol2013 MarWang Ydoi: 10.1128/MCB.01604-12
21165711Production and characterization of polyclonal and monoclonal Abs against the RNA-binding protein QKI.Appl Biochem Biotechnol2011 JunZhang Jdoi: 10.1007/s12010-010-9134-6
20631256The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation.Mol Biol Cell2010 Sep 1Doukhanine Edoi: 10.1091/mbc.E10-04-0305
27196066Expression of Quaking RNA-Binding Protein in the Adult and Developing Mouse Retina.PLoS One2016 May 19Suiko Tdoi: 10.1371/journal.pone.0156033
26645409Oligodendroglial defects during quakingviable cerebellar development.Dev Neurobiol2016 SepMyers KRdoi: 10.1002/dneu.22369
28723670-----
29137254Quaking-5 suppresses aggressiveness of lung cancer cells through inhibiting β-catenin signaling pathway.Oncotarget2017 Jul 7Zhou Xdoi: 10.18632/oncotarget.19066
15528192Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation.J Biol Chem2005 Jan 7Lu Z-
22398723The RNA-binding protein QKI5 is a direct target of C/EBPα and delays macrophage differentiation.Mol Biol Cell2012 MayFu Hdoi: 10.1091/mbc.E11-05-0412
9671495Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization.Mol Cell Biol1998 AugChen T-
9547512Four isoforms of the signal-transduction and RNA-binding protein QKI expressed during chicken spermatogenesis.Mol Reprod Dev1998 MayMezquita J-
9486543Cloning and expression of the quaking gene in the zebrafish embryo.Mech Dev1997 DecTanaka H-
8987822Neural cell type-specific expression of QKI proteins is altered in quakingviable mutant mice.J Neurosci1996 Dec 15Hardy RJ-
10328999Contrasting effects of ENU induced embryonic lethal mutations of the quaking gene.Genomics1999 May 1Cox RD-
12467586Nuclear retention of MBP mRNAs in the quaking viable mice.Neuron2002 Dec 5Larocque D-
16470614Visceral endoderm function is regulated by quaking and required for vascular development.Genesis2006 FebBohnsack BL-
11856480Expression of Hqk encoding a KH RNA binding protein is altered in human glioma.Jpn J Cancer Res2002 FebLi ZZ-
16445981RNA metabolism and dysmyelination in schizophrenia.Neurosci Biobehav Rev2006McInnes LA-
11500840The fates of cells generated at the end of neurogenesis in developing mouse cortex.J Neurobiol2001 Sep 15Levers TE-
11178867Expression of QKI proteins and MAP1B identifies actively myelinating oligodendrocytes in adult rat brain.Mol Cell Neurosci2001 FebWu HY-
16342280Human QKI, a new candidate gene for schizophrenia involved in myelination.Am J Med Genet B Neuropsychiatr Genet2006 Jan 5Aberg K-
10864952Destabilization and mislocalization of myelin basic protein mRNAs in quaking dysmyelination lacking the QKI RNA-binding proteins.J Neurosci2000 Jul 1Li Z-
16855020QKI binds MAP1B mRNA and enhances MAP1B expression during oligodendrocyte development.Mol Biol Cell2006 OctZhao L-
15273320Specificity of the STAR/GSG domain protein Qk1: implications for the regulation of myelination.RNA2004 SepRyder SP-
19727426Essential function, sophisticated regulation and pathological impact of the selective RNA-binding protein QKI in CNS myelin development.Future Neurol2008 NovBockbrader K-
19686745RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer.Gastroenterology2010 JanYang Gdoi: 10.1053/j.gastro.2009.08.001
19545858Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder.Biol Psychiatry2009 Nov 1Klempan TAdoi: 10.1016/j.biopsych.2009.05.010
19335891Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells.BMC Pharmacol2009 Mar 31Jiang Ldoi: 10.1186/1471-2210-9-6.
18938205No association found between the promoter variations of QKI and schizophrenia in the Chinese population.Prog Neuropsychopharmacol Biol Psychiatry2009 Feb 1Huang Kdoi: 10.1016/j.pnpbp.2008.09.027
22982292Structural analysis of the quaking homodimerization interface.J Mol Biol2012 Nov 9Beuck Cdoi: 10.1016/j.jmb.2012.08.027
17575274The selective RNA-binding protein quaking I (QKI) is necessary and sufficient for promoting oligodendroglia differentiation.J Biol Chem2007 Aug 10Chen Y-
17132940QUAKING KH domain proteins as regulators of glial cell fate and myelination.RNA Biol2005 AprLarocque D-
17079655Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI.J Neurosci2006 Nov 1Zhao L-
22569043Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis.Biochem Biophys Res Commun2012 May 25Bian Ydoi: 10.1016/j.bbrc.2012.04.138
22479211Phosphorylation of the Drosophila melanogaster RNA-binding protein HOW by MAPK/ERK enhances its dimerization and activity.PLoS Genet2012Nir Rdoi: 10.1371/journal.pgen.1002632
22178871RNA binding protein QKI inhibits the ischemia/reperfusion-induced apoptosis in neonatal cardiomyocytes.Cell Physiol Biochem2011Guo Wdoi: 10.1159/000335755
23321059RNA-binding protein QKI regulates Glial fibrillary acidic protein expression in human astrocytes.Hum Mol Genet2013 Apr 1Radomska KJdoi: 10.1093/hmg/dds553
21768773E2F1 and RNA binding protein QKI comprise a negative feedback in the cell cycle regulation.Cell Cycle2011 Aug 15Yang G-
20956316Quaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein.Proc Natl Acad Sci U S A2010 Nov 2Zhao Ldoi: 10.1073/pnas.1007487107
20862255The QKI-6 RNA binding protein localizes with the MBP mRNAs in stress granules of glial cells.PLoS One2010 Sep 17Wang Ydoi: 10.1371/journal.pone.0012824.
25457822QKI-5 suppresses cyclin D1 expression and proliferation of oral squamous cell carcinoma cells via MAPK signalling pathway.Int J Oral Maxillofac Surg2015 MayFu Xdoi: 10.1016/j.ijom.2014.10.001
25420938MicroRNA-155 promotes the proliferation and invasion abilities of colon cancer cells by targeting quaking.Mol Med Rep2015 MarHe Bdoi: 10.3892/mmr.2014.2994
25068621QKI deficiency promotes FoxO1 mediated nitrosative stress and endoplasmic reticulum stress contributing to increased vulnerability to ischemic injury in diabetic heart.J Mol Cell Cardiol2014 OctGuo Wdoi: 10.1016/j.yjmcc.2014.07.010
24918581QKI impairs self-renewal and tumorigenicity of oral cancer cells via repression of SOX2.Cancer Biol Ther2014 SepLu Wdoi: 10.4161/cbt.29502
24658850RNA-binding proteins in neurological diseases.Sci China Life Sci2014 AprZhou H-
24398626Post-transcriptional repression of FOXO1 by QKI results in low levels of FOXO1 expression in breast cancer cells.Oncol Rep2014 MarYu Fdoi: 10.3892/or.2013.2957
23963726Quaking, an RNA-binding protein, is a critical regulator of vascular smooth muscle cell phenotype.Circ Res2013 Oct 12van der Veer EPdoi: 10.1161/CIRCRESAHA.113.301302
23630077Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites.Genes Dev2013 Apr 15Teplova Mdoi: 10.1101/gad.216531.113.
28179294Clinical Significance of Methylation and Reduced Expression of the Quaking Gene in Colorectal Cancer.Anticancer Res2017 FebIwata N-
24792162A cytoplasmic quaking I isoform regulates the hnRNP F/H-dependent alternative splicing pathway in myelinating glia.Nucleic Acids Res2014 JunMandler MDdoi: 10.1093/nar/gku353
27053216Quaking Regulates Neurofascin 155 Expression for Myelin and Axoglial Junction Maintenance.J Neurosci2016 Apr 6Darbelli Ldoi: 10.1523/JNEUROSCI.3529-15.2016.
27029405Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression.Nat Commun2016 Mar 31de Bruin RGdoi: 10.1038/ncomms10846.
28283792Extracellular vesicles-mediated transfer of miR-208a/b exaggerate hypoxia/reoxygenation injury in cardiomyocytes by reducing QKI expression.Mol Cell Biochem2017 JulWang Fdoi: 10.1007/s11010-017-2990-4
26926106The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.Nucleic Acids Res2016 Apr 7Yamagishi Rdoi: 10.1093/nar/gkw118
26337206Quaking and miR-155 interactions in inflammation and leukemogenesis.Oncotarget2015 Sep 22Tili Edoi: 10.18632/oncotarget.5248.
26056009miR-29a promotes scavenger receptor A expression by targeting QKI (quaking) during monocyte-macrophage differentiation.Biochem Biophys Res Commun2015 Aug 14Wang Sdoi: 10.1016/j.bbrc.2015.05.019
28186995MicroRNA-214 regulates smooth muscle cell differentiation from stem cells by targeting RNA-binding protein QKI.Oncotarget2017 Mar 21Wu Ydoi: 10.18632/oncotarget.15189.
28552414QKI6B mRNA levels are upregulated in schizophrenia and predict GFAP expression.Brain Res2017 Aug 15Farnsworth Bdoi: 10.1016/j.brainres.2017.05.027
26920226Posttranscriptional regulation of FOXO expression: microRNAs and beyond.Br J Pharmacol2017 JunUrbanek Pdoi: 10.1111/bph.13471
27454326The oligodendrocyte-specific antibody 'CC1' binds Quaking 7.J Neurochem2016 OctBin JMdoi: 10.1111/jnc.13745
28654916-----
28790308Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing.Sci Rep2017 Aug 8Darbelli Ldoi: 10.1038/s41598-017-06211-1.
28881683Inhibition of COX2 enhances the chemosensitivity of dichloroacetate in cervical cancer cells.Oncotarget2017 Jun 16Li Bdoi: 10.18632/oncotarget.18518
29021239An RNA-binding protein, Qki5, regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling.Genes Dev2017 Sep 15Hayakawa-Yano Ydoi: 10.1101/gad.300822.117
29276519Quaking Deficiency Amplifies Inflammation in Experimental Endotoxemia via the Aryl Hydrocarbon Receptor/Signal Transducer and Activator of Transcription 1-NF-kB Pathway.Front Immunol2017 Dec 8Wang Ldoi: 10.3389/fimmu.2017.01754
29658587Androgen receptormediated upregulation of quaking affects androgen receptorrelated prostate cancer development and antiandrogen receptor therapy.Mol Med Rep2018 JunZhang Kdoi: 10.3892/mmr.2018.8882
29861871The miR-17-92 cluster/QKI2/β-catenin axis promotes osteosarcoma progression.Oncotarget2018 Jan 5Yang Hdoi: 10.18632/oncotarget.23935
29871889miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking.EMBO J2018 Jul 2Pillman KAdoi: 10.15252/embj.201899016
30664220SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPARα/FoxO1 signaling pathway.Int J Mol Med2019 MarZhang Wdoi: 10.3892/ijmm.2019.4059
30918328Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis.Oncogene2019 JunAzam SHdoi: 10.1038/s41388-019-0786-6
31026342QKI, a miR-200 target gene, suppresses epithelial-to-mesenchymal transition and tumor growth.Int J Cancer2019 Sep 15Kim EJdoi: 10.1002/ijc.32372
31191799MicroRNA-155 Promotes Myocardial Infarction-Induced Apoptosis by Targeting RNA-Binding Protein QKI.Oxid Med Cell Longev2019 May 5Guo Jdoi: 10.1155/2019/4579806
31284728Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins.Circulation2019 Jul 9Chothani Sdoi: 10.1161/CIRCULATIONAHA.119.039596
31289476Overexpression of miR-20a promotes the progression of osteosarcoma by directly targeting QKI2.Oncol Lett2019 JulYang Hdoi: 10.3892/ol.2019.10313
31331967The RNA binding protein QKI controls alternative splicing as a model of vascular therapies.J Cell Sci2019 Jul 22Caines Rdoi: 10.1242/jcs.230276
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000537124QKI-209551-ENSP0000044310647 (aa)-F5H5U6
ENST00000424802QKI-206954XM_011536259ENSP00000408382317 (aa)XP_011534561Q96PU8
ENST00000361752QKI-2039463XM_011536258ENSP00000355094341 (aa)XP_011534560Q96PU8
ENST00000541696QKI-2121097--- (aa)--
ENST00000544823QKI-215597-ENSP00000440599170 (aa)-F5GYM3
ENST00000544361QKI-213613-ENSP00000442848185 (aa)-H0YGD6
ENST00000544436QKI-214495-ENSP00000443690100 (aa)-F5H8C8
ENST00000361195QKI-2021063-ENSP00000354867333 (aa)-Q96PU8
ENST00000540719QKI-211588--- (aa)--
ENST00000545346QKI-216457-ENSP0000044125241 (aa)-F5GYT7
ENST00000361758QKI-2046085-ENSP00000354951319 (aa)-Q96PU8
ENST00000392127QKI-2057911-ENSP00000375973319 (aa)-Q96PU8
ENST00000537883QKI-2101106-ENSP00000441773238 (aa)-H0YG47
ENST00000275262QKI-2016964-ENSP00000275262325 (aa)-Q96PU8
ENST00000453779QKI-2075685XM_017011503ENSP00000408775319 (aa)XP_016866992Q96PU8
ENST00000545607QKI-217846-ENSP0000043786734 (aa)-H0YFB7
ENST00000537041QKI-208583-ENSP00000440991160 (aa)-F5GXS8
Gene Model
Click here to download ENSG00000112531's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000112531Body Height8.25066069845004E-517903300
ENSG00000112531Body Height1.17594809259103E-517903300
ENSG00000112531Body Height4.40768165814731E-517903300
ENSG00000112531Body Height5.81981414238621E-517903300
ENSG00000112531Body Height4.40768165814731E-517903300
ENSG00000112531Body Height4.4458022995908E-517903300
ENSG00000112531Body Height3.62763234362795E-517903300
ENSG00000112531Body Height4.68117494687448E-517903300
ENSG00000112531Body Weight3.69127265951175E-517903300
ENSG00000112531Body Weight Changes2.22427764085245E-617903300
ENSG00000112531Triglycerides1.58397429093284E-517903299
ENSG00000112531Carotid Artery Diseases8.1481609117029E-517903303
ENSG00000112531Aorta6.797508678276E-1817903303
ENSG00000112531Aorta3.01823459731801E-1717903303
ENSG00000112531Aorta2.31719215431588E-1517903303
ENSG00000112531Aorta1.18266148703311E-1517903303
ENSG00000112531Vitamin D3.61188581941008E-517903293
ENSG00000112531Echocardiography6.07187478532364E-517903301
ENSG00000112531Echocardiography4.6411424362347E-517903301
ENSG00000112531Echocardiography5.33915481124376E-617903301
ENSG00000112531Echocardiography5.73311798190979E-617903301
ENSG00000112531Echocardiography2.92524605299033E-617903301
ENSG00000112531Echocardiography6.22830791731421E-717903301
ENSG00000112531Echocardiography2.00799443155208E-517903301
ENSG00000112531Echocardiography4.47512638973126E-617903301
ENSG00000112531Echocardiography9.20722888706575E-617903301
ENSG00000112531Echocardiography9.64422832128164E-617903301
ENSG00000112531Echocardiography4.69442693592287E-617903301
ENSG00000112531Echocardiography1.1679425376545E-617903301
ENSG00000112531Echocardiography2.50887284445334E-517903301
ENSG00000112531Echocardiography7.39467436966642E-617903301
ENSG00000112531Pulse7.15715792973803E-517903302
ENSG00000112531Electrocardiography2.15687394881314E-517903302
ENSG00000112531Electrocardiography3.42791945327309E-517903302
ENSG00000112531lipoprotein A-I5.004556E-1619124843
ENSG00000112531lipoprotein A-I7.613696E-1119124843
ENSG00000112531lipoprotein A-I1.23446E-0719124843
ENSG00000112531lipoprotein A-I2.14934E-0719124843
ENSG00000112531lipoprotein A-I3.452318E-0819124843
ENSG00000112531lipoprotein A-I6.760902E-1419124843
ENSG00000112531lipoprotein A-I8.471534E-0819124843
ENSG00000112531lipoprotein A-I2.748571E-0919124843
ENSG00000112531Myocardial Infarction6.5810816E-005-
ENSG00000112531Alcoholism7.67293e-00522978509
ENSG00000112531Alcoholism9.1868e-00522978509
ENSG00000112531Alcoholism6.68083e-00522978509
ENSG00000112531Alcoholism3.16603e-00522978509
ENSG00000112531Alcoholism4.00055e-00522978509
ENSG00000112531Alcoholism4.73701e-00522978509
ENSG00000112531Alcoholism5.36976e-00522978509
ENSG00000112531Choice Behavior9.891e-005-
ENSG00000112531Body Fat Distribution5.6470000E-005-
ENSG00000112531Body Fat Distribution4.8960000E-005-
ENSG00000112531Arteries8.5500000E-005-
ENSG00000112531Arteries8.7940000E-005-
ENSG00000112531Arteries2.6970000E-005-
ENSG00000112531Arteries2.6970000E-005-
ENSG00000112531Arteries2.6970000E-005-
ENSG00000112531Arteries8.5500000E-005-
ENSG00000112531Nutritional and Metabolic Diseases7.1830000E-005-
ENSG00000112531Eosinophils4.8340000E-005-
ENSG00000112531Eosinophils4.1370000E-005-
ENSG00000112531Hematocrit5.9620000E-005-
ENSG00000112531Erythrocyte Count2.4220000E-006-
ENSG00000112531Respiratory Function Tests7.0060000E-005-
ENSG00000112531Blood Pressure7.3817246E-005-
ENSG00000112531Body Mass Index9.4799057E-005-
ENSG00000112531Body Mass Index5.3915346E-005-
ENSG00000112531Glomerular Filtration Rate8.9243970E-005-
ENSG00000112531Platelet Function Tests2.0368300E-005-
ENSG00000112531Platelet Function Tests2.2384000E-005-
ENSG00000112531Platelet Function Tests1.3185400E-005-
ENSG00000112531Platelet Function Tests1.0893800E-005-
ENSG00000112531Platelet Function Tests4.8300000E-006-
ENSG00000112531Platelet Function Tests1.4025300E-005-
ENSG00000112531Platelet Function Tests2.3700000E-006-
ENSG00000112531Platelet Function Tests1.6104900E-005-
ENSG00000112531Platelet Function Tests1.3050400E-005-
ENSG00000112531Liver Cirrhosis, Biliary1.0690000E-00520639880
ENSG00000112531Child Development Disorders, Pervasive9.2543000E-006-
ENSG00000112531Child Development Disorders, Pervasive1.6633000E-005-
ENSG00000112531Child Development Disorders, Pervasive9.8000000E-005-
ENSG00000112531Child Development Disorders, Pervasive9.9000000E-005-
ENSG00000112531Insulin4.7740000E-005-
ENSG00000112531alpha-Macroglobulins2.2980000E-005-
ENSG00000112531Fibrinogen2.6520000E-005-
ENSG00000112531Erythrocyte Indices2.5190000E-005-
ENSG00000112531Erythrocyte Indices2.5190000E-005-
ENSG00000112531Erythrocyte Indices2.5190000E-005-
ENSG00000112531Warfarin5.7160000E-005-
ENSG00000112531Warfarin5.8670000E-006-
ENSG00000112531Warfarin4.1740000E-006-
ENSG00000112531Coronary Disease9.9800000E-006-
ENSG00000112531Myocardial Infarction1.9630000E-007-
ENSG00000112531Myocardial Infarction3.1110000E-007-
ENSG00000112531Myocardial Infarction3.6530000E-006-
ENSG00000112531Myocardial Infarction1.4150000E-006-
ENSG00000112531Asthma7E-625918132
ENSG00000112531Toluene 2,4-Diisocyanate7E-625918132
ENSG00000112531Polychlorinated Biphenyls2E-725839716
ENSG00000112531Schizophrenia7E-626198764
ENSG00000112531Polychlorinated Biphenyls4E-825839716
ENSG00000112531Longevity5E-827015805
ENSG00000112531Myocardial Infarction6E-926950853
ENSG00000112531Adipose Tissue3E-622589738
ENSG00000112531Body Mass Index3E-622589738
ENSG00000112531Polychlorinated Biphenyls8E-725839716
ENSG00000112531Erythrocyte Count6E-728017375
ENSG00000112531Tumor Necrosis Factors3E-718615156
ENSG00000112531Psychotic Disorders1E-626821981
ENSG00000112531Schizophrenia1E-626821981
ENSG00000112531Antipsychotic Agents1E-626821981
ENSG00000112531Polychlorinated Biphenyls1E-725839716
ENSG00000112531Asthma2E-724824216
ENSG00000112531Gestational Age3E-627490719
ENSG00000112531Live Birth3E-627490719
ENSG00000112531Depressive Disorder9E-620516156
ENSG00000112531Alcoholism8E-727151647
ENSG00000112531Autosomal dominant compelling helio ophthalmic outburst syndrome3E-1027182965
ENSG00000112531Polychlorinated Biphenyls7E-725839716
ENSG00000112531Neurofibrillary Tangles4E-625188341
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000112531rs94588596163562826?Red blood cell count30595370EFO_0004305
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000112531's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000112531QKI7655.128ENSG00000112232KHDRBS27736.396
ENSG00000112531QKI7655.128ENSG00000131773KHDRBS38146.212
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000112531QKI10086.275ENSAPOG00000002713qki210078.947Acanthochromis_polyacanthus
ENSG00000112531QKI100100.000ENSAMEG00000008459QKI9999.107Ailuropoda_melanoleuca
ENSG00000112531QKI10086.275ENSAOCG00000014271qki210078.947Amphiprion_ocellaris
ENSG00000112531QKI10086.275ENSAPEG00000008210qki210078.947Amphiprion_percula
ENSG00000112531QKI10095.000ENSATEG00000022584qkib9381.595Anabas_testudineus
ENSG00000112531QKI10085.294ENSATEG00000004355qki210078.233Anabas_testudineus
ENSG00000112531QKI100100.000ENSAPLG00000010080QKI10099.308Anas_platyrhynchos
ENSG00000112531QKI100100.000ENSACAG00000003270QKI10097.947Anolis_carolinensis
ENSG00000112531QKI100100.000ENSANAG00000029669QKI100100.000Aotus_nancymaae
ENSG00000112531QKI10090.000ENSACLG00000007900qkib9179.310Astatotilapia_calliptera
ENSG00000112531QKI10085.294ENSACLG00000026838qki210078.328Astatotilapia_calliptera
ENSG00000112531QKI10097.872ENSAMXG00000015808qkib10092.879Astyanax_mexicanus
ENSG00000112531QKI9997.041ENSAMXG00000042623qki210091.250Astyanax_mexicanus
ENSG00000112531QKI100100.000ENSBTAG00000011593QKI100100.000Bos_taurus
ENSG00000112531QKI100100.000ENSCJAG00000012368QKI100100.000Callithrix_jacchus
ENSG00000112531QKI100100.000ENSCAFG00000000772QKI100100.000Canis_familiaris
ENSG00000112531QKI100100.000ENSCAFG00020019085QKI100100.000Canis_lupus_dingo
ENSG00000112531QKI100100.000ENSCHIG00000018891QKI100100.000Capra_hircus
ENSG00000112531QKI100100.000ENSTSYG00000036757QKI100100.000Carlito_syrichta
ENSG00000112531QKI100100.000ENSCCAG00000025230QKI100100.000Cebus_capucinus
ENSG00000112531QKI100100.000ENSCATG00000037623-100100.000Cercocebus_atys
ENSG00000112531QKI100100.000ENSCLAG00000006238-100100.000Chinchilla_lanigera
ENSG00000112531QKI100100.000ENSCSAG00000012257QKI10097.361Chlorocebus_sabaeus
ENSG00000112531QKI100100.000ENSCHOG00000006651QKI9789.728Choloepus_hoffmanni
ENSG00000112531QKI94100.000ENSCPBG00000019817QKI10087.097Chrysemys_picta_bellii
ENSG00000112531QKI100100.000ENSCANG00000000415QKI100100.000Colobus_angolensis_palliatus
ENSG00000112531QKI100100.000ENSCGRG00001012114Qk100100.000Cricetulus_griseus_chok1gshd
ENSG00000112531QKI100100.000ENSCGRG00000011540Qk100100.000Cricetulus_griseus_crigri
ENSG00000112531QKI10084.314ENSCSEG00000013480qki29577.259Cynoglossus_semilaevis
ENSG00000112531QKI10085.294ENSCVAG00000013803qki29978.261Cyprinodon_variegatus
ENSG00000112531QKI9997.041ENSDARG00000010018qki210090.625Danio_rerio
ENSG00000112531QKI10099.000ENSDARG00000002026qkib10099.254Danio_rerio
ENSG00000112531QKI100100.000ENSDORG00000008151Qk100100.000Dipodomys_ordii
ENSG00000112531QKI10099.000ENSETEG00000007676QKI10099.317Echinops_telfairi
ENSG00000112531QKI10080.392ENSEBUG00000013799qki29957.514Eptatretus_burgeri
ENSG00000112531QKI10081.000ENSEBUG00000009508qki29960.778Eptatretus_burgeri
ENSG00000112531QKI100100.000ENSEASG00005019724QKI100100.000Equus_asinus_asinus
ENSG00000112531QKI100100.000ENSECAG00000017504QKI100100.000Equus_caballus
ENSG00000112531QKI100100.000ENSEEUG00000012054QKI10083.276Erinaceus_europaeus
ENSG00000112531QKI9984.472ENSELUG00000002282qki210070.821Esox_lucius
ENSG00000112531QKI10097.000ENSELUG00000016698QKI10090.237Esox_lucius
ENSG00000112531QKI100100.000ENSFCAG00000019399QKI10099.700Felis_catus
ENSG00000112531QKI100100.000ENSFALG00000012183QKI9797.959Ficedula_albicollis
ENSG00000112531QKI100100.000ENSFDAG00000006081QKI100100.000Fukomys_damarensis
ENSG00000112531QKI10085.294ENSFHEG00000009423qki29978.841Fundulus_heteroclitus
ENSG00000112531QKI9984.375ENSGMOG00000004107qki29973.276Gadus_morhua
ENSG00000112531QKI100100.000ENSGALG00000011555QKI10098.827Gallus_gallus
ENSG00000112531QKI10085.294ENSGAFG00000011092qki29977.259Gambusia_affinis
ENSG00000112531QKI10084.314ENSGACG00000003206qki210077.709Gasterosteus_aculeatus
ENSG00000112531QKI100100.000ENSGAGG00000003901QKI10099.399Gopherus_agassizii
ENSG00000112531QKI100100.000ENSGGOG00000000733QKI100100.000Gorilla_gorilla
ENSG00000112531QKI10090.000ENSHBUG00000015851qkib9180.380Haplochromis_burtoni
ENSG00000112531QKI10085.294ENSHBUG00000009123qki210078.638Haplochromis_burtoni
ENSG00000112531QKI100100.000ENSHGLG00000003074-100100.000Heterocephalus_glaber_female
ENSG00000112531QKI100100.000ENSHGLG00100000339-100100.000Heterocephalus_glaber_male
ENSG00000112531QKI10084.314ENSHCOG00000015404qki29976.163Hippocampus_comes
ENSG00000112531QKI94100.000ENSIPUG00000014732qki210090.000Ictalurus_punctatus
ENSG00000112531QKI10099.000ENSIPUG00000012637qki10092.593Ictalurus_punctatus
ENSG00000112531QKI100100.000ENSSTOG00000009113QKI100100.000Ictidomys_tridecemlineatus
ENSG00000112531QKI100100.000ENSJJAG00000022765Qk10099.278Jaculus_jaculus
ENSG00000112531QKI10086.275ENSKMAG00000009024qki210078.947Kryptolebias_marmoratus
ENSG00000112531QKI9496.875ENSLBEG00000022702qkib9368.693Labrus_bergylta
ENSG00000112531QKI10084.314ENSLBEG00000027428qki210078.947Labrus_bergylta
ENSG00000112531QKI10098.750ENSLACG00000015585QKI10096.864Latimeria_chalumnae
ENSG00000112531QKI10098.000ENSLOCG00000016506qki210097.500Lepisosteus_oculatus
ENSG00000112531QKI100100.000ENSLAFG00000021654QKI10097.260Loxodonta_africana
ENSG00000112531QKI100100.000ENSMFAG00000044069-100100.000Macaca_fascicularis
ENSG00000112531QKI100100.000ENSMMUG00000000428-100100.000Macaca_mulatta
ENSG00000112531QKI10087.234ENSMMUG00000049158-9573.540Macaca_mulatta
ENSG00000112531QKI100100.000ENSMNEG00000043724-9994.311Macaca_nemestrina
ENSG00000112531QKI100100.000ENSMLEG00000033347-100100.000Mandrillus_leucophaeus
ENSG00000112531QKI10093.000ENSMAMG00000022446qkib9283.125Mastacembelus_armatus
ENSG00000112531QKI10085.294ENSMAMG00000003069qki29977.681Mastacembelus_armatus
ENSG00000112531QKI10085.294ENSMZEG00005004737qki210078.328Maylandia_zebra
ENSG00000112531QKI10090.000ENSMZEG00005018363qkib9179.747Maylandia_zebra
ENSG00000112531QKI100100.000ENSMGAG00000012341QKI10097.232Meleagris_gallopavo
ENSG00000112531QKI10099.000ENSMAUG00000001920Qk10098.917Mesocricetus_auratus
ENSG00000112531QKI100100.000ENSMICG00000009220QKI100100.000Microcebus_murinus
ENSG00000112531QKI10099.412ENSMOCG00000008370Qk10099.659Microtus_ochrogaster
ENSG00000112531QKI10084.314ENSMMOG00000020767qki210078.328Mola_mola
ENSG00000112531QKI10088.000ENSMMOG00000007933qkib9378.154Mola_mola
ENSG00000112531QKI100100.000ENSMODG00000006434QKI10099.707Monodelphis_domestica
ENSG00000112531QKI10093.000ENSMALG00000009475qkib9377.914Monopterus_albus
ENSG00000112531QKI10084.314ENSMALG00000015261qki210078.638Monopterus_albus
ENSG00000112531QKI100100.000MGP_CAROLIEiJ_G0021057Qk100100.000Mus_caroli
ENSG00000112531QKI100100.000ENSMUSG00000062078Qk100100.000Mus_musculus
ENSG00000112531QKI100100.000MGP_PahariEiJ_G0023373Qk100100.000Mus_pahari
ENSG00000112531QKI100100.000MGP_SPRETEiJ_G0021963Qk100100.000Mus_spretus
ENSG00000112531QKI100100.000ENSMPUG00000006368QKI100100.000Mustela_putorius_furo
ENSG00000112531QKI10099.412ENSMLUG00000002829QKI9997.342Myotis_lucifugus
ENSG00000112531QKI10098.824ENSNGAG00000009989Qk10099.317Nannospalax_galili
ENSG00000112531QKI10086.275ENSNBRG00000007549qki210076.737Neolamprologus_brichardi
ENSG00000112531QKI100100.000ENSNLEG00000011478-10091.809Nomascus_leucogenys
ENSG00000112531QKI100100.000ENSMEUG00000008112QKI9088.213Notamacropus_eugenii
ENSG00000112531QKI10099.000ENSOPRG00000011662QKI10098.976Ochotona_princeps
ENSG00000112531QKI100100.000ENSODEG00000007408QKI100100.000Octodon_degus
ENSG00000112531QKI10086.275ENSONIG00000008011qki210078.638Oreochromis_niloticus
ENSG00000112531QKI10088.000ENSONIG00000007133qkib9779.688Oreochromis_niloticus
ENSG00000112531QKI100100.000ENSOANG00000011161QKI9897.872Ornithorhynchus_anatinus
ENSG00000112531QKI100100.000ENSOCUG00000004117-9799.653Oryctolagus_cuniculus
ENSG00000112531QKI10086.275ENSORLG00000027996qki210078.328Oryzias_latipes
ENSG00000112531QKI10084.314ENSOMEG00000007147qki210078.328Oryzias_melastigma
ENSG00000112531QKI100100.000ENSOGAG00000003634QKI100100.000Otolemur_garnettii
ENSG00000112531QKI100100.000ENSOARG00000004811QKI100100.000Ovis_aries
ENSG00000112531QKI100100.000ENSPPAG00000038059-100100.000Pan_paniscus
ENSG00000112531QKI100100.000ENSPPRG00000013383QKI10099.707Panthera_pardus
ENSG00000112531QKI100100.000ENSPTIG00000008797QKI8699.659Panthera_tigris_altaica
ENSG00000112531QKI100100.000ENSPTRG00000018785QKI100100.000Pan_troglodytes
ENSG00000112531QKI100100.000ENSPANG00000006711-100100.000Papio_anubis
ENSG00000112531QKI9996.203ENSPKIG00000010813qki210086.420Paramormyrops_kingsleyae
ENSG00000112531QKI94100.000ENSPKIG00000002778-10083.438Paramormyrops_kingsleyae
ENSG00000112531QKI100100.000ENSPSIG00000012197QKI10099.413Pelodiscus_sinensis
ENSG00000112531QKI10085.149ENSPMGG00000010555-9674.540Periophthalmus_magnuspinnatus
ENSG00000112531QKI100100.000ENSPEMG00000007765Qk100100.000Peromyscus_maniculatus_bairdii
ENSG00000112531QKI100100.000ENSPCIG00000020191QKI10099.707Phascolarctos_cinereus
ENSG00000112531QKI10085.294ENSPFOG00000014078qki29976.487Poecilia_formosa
ENSG00000112531QKI10085.294ENSPLAG00000020354qki210078.947Poecilia_latipinna
ENSG00000112531QKI10085.294ENSPMEG00000004997qki210077.341Poecilia_mexicana
ENSG00000112531QKI10085.294ENSPREG00000009154qki210078.638Poecilia_reticulata
ENSG00000112531QKI100100.000ENSPPYG00000017160QKI10098.220Pongo_abelii
ENSG00000112531QKI10099.000ENSPCAG00000007832-55100.000Procavia_capensis
ENSG00000112531QKI10097.872ENSPVAG00000015228QKI10082.935Pteropus_vampyrus
ENSG00000112531QKI10085.294ENSPNYG00000004751qki210076.435Pundamilia_nyererei
ENSG00000112531QKI10099.000ENSPNAG00000002418qkib8193.015Pygocentrus_nattereri
ENSG00000112531QKI10096.000ENSPNAG00000026483qki210091.250Pygocentrus_nattereri
ENSG00000112531QKI100100.000ENSRNOG00000048297LOC10834817510098.810Rattus_norvegicus
ENSG00000112531QKI100100.000ENSRBIG00000043656QKI100100.000Rhinopithecus_bieti
ENSG00000112531QKI100100.000ENSRROG00000040592QKI100100.000Rhinopithecus_roxellana
ENSG00000112531QKI10098.824ENSSBOG00000036267QKI10099.278Saimiri_boliviensis_boliviensis
ENSG00000112531QKI100100.000ENSSHAG00000014127QKI9799.598Sarcophilus_harrisii
ENSG00000112531QKI10098.000ENSSFOG00015000145qki10095.611Scleropages_formosus
ENSG00000112531QKI10096.000ENSSFOG00015003466qki210089.062Scleropages_formosus
ENSG00000112531QKI10084.314ENSSMAG00000006070qki210077.090Scophthalmus_maximus
ENSG00000112531QKI10095.000ENSSDUG00000013229qkib9375.394Seriola_dumerili
ENSG00000112531QKI10085.294ENSSDUG00000013691qki210078.638Seriola_dumerili
ENSG00000112531QKI10085.294ENSSLDG00000017943qki210078.638Seriola_lalandi_dorsalis
ENSG00000112531QKI100100.000ENSSARG00000010852QKI10098.976Sorex_araneus
ENSG00000112531QKI10099.000ENSSPUG00000012200QKI10098.534Sphenodon_punctatus
ENSG00000112531QKI10085.294ENSSPAG00000002875qki210078.638Stegastes_partitus
ENSG00000112531QKI100100.000ENSSSCG00000004029QKI100100.000Sus_scrofa
ENSG00000112531QKI100100.000ENSTGUG00000009383QKI10092.262Taeniopygia_guttata
ENSG00000112531QKI10084.314ENSTRUG00000018041qki210078.019Takifugu_rubripes
ENSG00000112531QKI10084.314ENSTNIG00000011099qki29977.326Tetraodon_nigroviridis
ENSG00000112531QKI100100.000ENSTTRG00000012050QKI9998.827Tursiops_truncatus
ENSG00000112531QKI100100.000ENSUMAG00000011658QKI100100.000Ursus_maritimus
ENSG00000112531QKI100100.000ENSVPAG00000009566QKI100100.000Vicugna_pacos
ENSG00000112531QKI100100.000ENSVVUG00000001467QKI84100.000Vulpes_vulpes
ENSG00000112531QKI9995.882ENSXETG00000015705qki10093.769Xenopus_tropicalis
ENSG00000112531QKI10085.294ENSXCOG00000004131qki29571.207Xiphophorus_couchianus
ENSG00000112531QKI10085.294ENSXMAG00000017056qki29977.971Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22681889.HDAFunction
GO:0005515protein binding16189514.16713569.22365833.23455924.25416956.IPIFunction
GO:0005634nucleus-IEAComponent
GO:0005737cytoplasm-IEAComponent
GO:0006397mRNA processing-IEAProcess
GO:0006417regulation of translation-IEAProcess
GO:0007275multicellular organism development-IEAProcess
GO:0008380RNA splicing-IEAProcess
GO:0017124SH3 domain binding-IEAFunction
GO:0030154cell differentiation-IEAProcess
GO:0051028mRNA transport-IEAProcess
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