EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28892043Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking.Oncogene2018 Jan 11Corkery DPdoi: 10.1038/onc.2017.318
29695716Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K.Nat Commun2018 Apr 25Cho YSdoi: 10.1038/s41467-018-04090-2.
23686430Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53.Mol Cells2013 JunShehzad Adoi: 10.1007/s10059-013-0038-5
25602630PRP4K is a HER2-regulated modifier of taxane sensitivity.Cell Cycle2015Corkery DPdoi: 10.1080/15384101.2015.1007775.
26712520Estrogen receptor alpha (ESR1)-signaling regulates the expression of the taxane-response biomarker PRP4K.Exp Cell Res2016 Jan 1Lahsaee Sdoi: 10.1016/j.yexcr.2015.12.013

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr64037401Nonsense_MutationnovelR415*0.36
BLCAchr64049811SilentnovelV702V0.29
BLCAchr64056421Missense_MutationNAR856P0.21
BLCAchr640214045'UTRnovel0.3
BLCAchr64040846Missense_MutationnovelR496T0.54
BLCAchr64032265Missense_MutationnovelE250Q0.26
BLCAchr64058755Nonsense_MutationnovelQ921*0.21
BLCAchr64058787SilentNAY931Y0.15
BLCAchr64056412Missense_MutationnovelR853T0.08
BLCAchr64031634Nonsense_MutationnovelH40*0.2
BLCAchr64032421In_Frame_DelnovelD304_K310del0.32
BLCAchr64031626Missense_MutationnovelQ37E0.2
BRCAchr64031672Missense_MutationnovelS52N0.27
BRCAchr64032227Missense_MutationNAR237T0.43
BRCAchr64049068Missense_Mutationrs753689645N663S0.23
BRCAchr64047185Missense_MutationNAQ624H0.25
BRCAchr64056432Missense_MutationNAI860V0.32
BRCAchr64031878Missense_MutationnovelD121H0.07
BRCAchr64031919SilentNAG134G0.47
BRCAchr64021450Missense_MutationNAL9I0.31
BRCAchr64031777Missense_MutationnovelS87F0.19
BRCAchr640606213'UTRnovel0.11
BRCAchr64037549Missense_Mutationrs768895871R464K0.3
CESCchr640607223'UTRnovel0.54
CESCchr64049028Missense_MutationnovelR650W0.38
CESCchr640645333'Flanknovel0.55
CESCchr64058727Splice_SiteNAX912_splice0.29
CESCchr64032243In_Frame_InsnovelP242_T243insYFSFYQ0.07
CESCchr64037558Missense_MutationNAS467F0.31
CHOLchr640641423'Flanknovel0.4
CHOLchr64031994SilentnovelR159R0.08
COADchr64040824Missense_Mutationrs371719270G489S0.47
COADchr64043970Missense_MutationNAF603C0.34
COADchr64043921Nonsense_MutationnovelR587*0.27
COADchr64052741Frame_Shift_DelNAK780Nfs*130.5
COADchr64031842Missense_MutationNAL109V0.22
COADchr64031647Frame_Shift_Delrs776215135K46Rfs*580.41
COADchr64052740Frame_Shift_InsnovelY781Ifs*30.43
COADchr64031646Frame_Shift_InsNAK47Efs*30.28
COADchr64043895In_Frame_DelnovelP579del0.17
COADchr64052741Frame_Shift_DelNAK780Nfs*130.22
COADchr64057189Splice_SiteNAX911_splice0.33
COADchr64052740Frame_Shift_InsnovelY781Ifs*30.27
COADchr64032139Missense_Mutationrs200965972V208I0.05
COADchr64052741Frame_Shift_DelNAK780Nfs*130.12
COADchr64052741Frame_Shift_DelNAK780Nfs*130.41
COADchr64031796SilentNAS93S0.1
COADchr64043957Missense_MutationNAN599H0.09
COADchr64032435SilentNAR306R0.34
COADchr64060605Frame_Shift_InsnovelI1007Nfs*130.34
COADchr64040804Missense_MutationnovelR482L0.27
ESCAchr64052741Frame_Shift_DelNAK780Nfs*130.17
ESCAchr640614303'UTRnovel0.25
GBMchr64031647Frame_Shift_Delrs776215135K46Rfs*580.34
GBMchr64032065Missense_Mutationrs369146887R183Q0.14
GBMchr64037435Missense_MutationnovelR426I0.07
HNSCchr64044011Missense_MutationnovelE617Q0.16
HNSCchr64037527Missense_Mutationrs755637217R457C0.36
HNSCchr64052073Missense_MutationnovelC764Y0.32
HNSCchr64056602Intronnovel0.53
HNSCchr64032737Missense_MutationNAR407T0.21
HNSCchr64049029Missense_Mutationrs767764945R650Q0.35
HNSCchr64032419Missense_MutationNAK301R0.81
HNSCchr64043883Missense_MutationNAT574M0.74
KIRCchr64032297Missense_Mutationrs753209139D260E0.04
KIRCchr64032298Missense_Mutationrs756647734D261Y0.35
KIRPchr64047181Missense_MutationNAS623C0.32
KIRPchr64032066Frame_Shift_DelnovelS184Kfs*920.18
KIRPchr64032270Missense_MutationNAK251N0.41
LAMLchr64057088SilentNAT878T0.53
LAMLchr64049105Splice_Regionrs758029894Y675Y0.34
LGGchr64037437Missense_MutationnovelS427A0.45
LGGchr64032203Missense_MutationnovelR229I0.36
LGGchr64049812Nonsense_MutationnovelR703*0.34
LIHCchr640607883'UTRnovel0.26
LIHCchr64032705Silentrs751880533S396S0.12
LIHCchr64060515Nonsense_MutationnovelQ975*0.7
LIHCchr64057044Missense_MutationNAK864E0.21
LIHCchr64052872Missense_MutationNAL822P0.26
LIHCchr64032237SilentNAK240K0.27
LUADchr64051963Missense_MutationnovelK727N0.29
LUADchr64037563Missense_MutationNAR469G0.13
LUADchr64037435Missense_MutationNAR426T0.1
LUADchr64056360Missense_MutationnovelG836W0.27
LUADchr64037429Missense_MutationnovelR424L0.32
LUADchr64056361Missense_MutationnovelG836V0.25
LUADchr64047220Missense_MutationNAS636F0.12
LUADchr64052724Missense_MutationNAN773Y0.26
LUADchr64032524Missense_MutationNAG336V0.57
LUADchr64032065Missense_MutationnovelR183P0.52
LUADchr64032440Frame_Shift_DelnovelS309Pfs*630.26
LUSCchr64032400Missense_MutationNAP295S0.26
LUSCchr64032394Missense_MutationNAR293G0.31
LUSCchr64031624Missense_MutationnovelS36Y0.09
LUSCchr64052830Missense_MutationNAR808K0.68
LUSCchr64037482Missense_MutationnovelR442G0.11
LUSCchr64032443Missense_MutationNAS309F0.12
MESOchr64032303SilentnovelK262K0.26
OVchr64057105Missense_MutationnovelT884S0.3
OVchr64056364Nonsense_MutationnovelS837*0.09
OVchr64032737Missense_MutationNAR407T0.3
OVchr64032064Nonsense_MutationNAR183*0.25
PAADchr64060518SilentnovelL976L0.1
PRADchr64032677Missense_MutationnovelS387C0.12
READchr64031795Missense_MutationnovelS93Y0.35
READchr64031926Missense_Mutationrs149525756L137V0.32
READchr64037567Missense_MutationnovelR470I0.44
READchr64040816Missense_MutationNAR486Q0.45
READchr64057112Missense_MutationnovelK886N0.37
READchr64058734Nonsense_MutationNAR914*0.33
READchr64031903Missense_MutationnovelV129A0.07
SARCchr640621093'Flanknovel0.32
SARCchr64037548Missense_Mutationrs747367615R464G1
SARCchr640613073'UTRnovel0.48
SKCMchr64031577SilentnovelS20S0.22
SKCMchr64042496SilentnovelD526D0.19
SKCMchr64032198SilentNAS227S0.71
SKCMchr64032472Missense_MutationNAT319A0.68
SKCMchr64049033Silentrs145998699A651A0.18
SKCMchr64043892Missense_MutationNAR577Q0.35
SKCMchr64031569Missense_MutationnovelA18S0.2
SKCMchr64032198SilentNAS227S0.09
SKCMchr64032458Missense_Mutationrs143527062S314L0.46
SKCMchr64032138Silentrs745388886I207I0.13
SKCMchr64057087Missense_MutationNAT878I0.33
SKCMchr64040915Missense_Mutationrs775187928S519L0.31
SKCMchr64047235Missense_MutationnovelA641V0.18
SKCMchr64040782Missense_Mutationrs143126415R475W0.16
SKCMchr64057121Silentrs369806583F889F0.15
SKCMchr64060417Missense_MutationNAK942T0.43
SKCMchr64032565Missense_MutationnovelP350S0.29
STADchr64043850Missense_MutationNAV563A0.24
STADchr64032452Frame_Shift_InsnovelS314Ifs*50.33
STADchr64052741Frame_Shift_DelNAK780Nfs*130.33
STADchr64037451SilentNAS431S0.19
STADchr64052741Frame_Shift_DelNAK780Nfs*130.1
STADchr64031647Frame_Shift_Delrs776215135K46Rfs*580.45
STADchr64032658Missense_MutationNAS381P0.17
STADchr64052838Missense_MutationNAI811V0.07
STADchr64031647Frame_Shift_Delrs776215135K46Rfs*580.48
STADchr64032178Frame_Shift_DelnovelK222Nfs*590.22
STADchr64031647Frame_Shift_Delrs776215135K46Rfs*580.38
STADchr64040823Silentrs532267331R488R0.39
STADchr64031647Frame_Shift_Delrs776215135K46Rfs*580.24
STADchr64031956Nonsense_MutationNAE147*0.57
STADchr64043931Missense_MutationNAA590V0.36
STADchr64060563Nonsense_MutationNAR991*0.24
STADchr64056366Missense_MutationNAA838T0.33
STADchr64052741Frame_Shift_DelNAK780Nfs*130.19
UCECchr64037512Missense_Mutationrs758332324R452C0.33
UCECchr640607093'UTRnovel0.32
UCECchr64032138Silentrs745388886I207I0.34
UCECchr640213525'UTRnovel0.19
UCECchr64040782Missense_Mutationrs143126415R475W0.17
UCECchr64052762SilentnovelV785V0.4
UCECchr640609163'UTRnovel0.38
UCECchr64057095Missense_MutationNAE881K0.23
UCECchr640606273'UTRnovel0.2
UCECchr64031996Missense_MutationNAS160Y0.39
UCECchr64056388Missense_MutationnovelD845G0.24
UCECchr640646223'Flanknovel0.31
UCECchr640607093'UTRnovel0.42
UCECchr64049875Missense_MutationNAL724V0.49
UCECchr64058786Missense_MutationNAY931F0.17
UCECchr64031655Missense_MutationnovelK46N0.42
UCECchr64031641Missense_MutationnovelR42C0.3
UCECchr64032138Silentrs745388886I207I0.4
UCECchr64057115Missense_MutationnovelI887M0.43
UCECchr64040815Nonsense_MutationNAR486*0.4
UCECchr64043920SilentnovelE586E0.25
UCECchr640615163'UTRnovel0.28
UCECchr640626163'Flanknovel0.55
UCECchr640642893'Flanknovel0.52
UCECchr64032478Missense_MutationnovelK321Q0.28
UCECchr64032554Missense_MutationNAP346H0.25
UCECchr64031563Missense_MutationNAE16K0.38
UCECchr64032385Missense_MutationNAK290E0.56
UCECchr64052093Missense_MutationNAS771G0.34
UCECchr64032463Missense_Mutationrs757614917R316W0.12
UCECchr640608013'UTRnovel0.24
UCECchr64057115Missense_MutationnovelI887M0.37
UCECchr640614893'UTRnovel0.3
UCECchr640642163'Flanknovel0.39
UCECchr640614293'UTRnovel0.38
UCECchr64040822Missense_Mutationrs780716502R488H0.33
UCECchr64049072SilentNAL664L0.28
UCECchr64060605Frame_Shift_InsnovelI1007Nfs*130.42
UCECchr640607093'UTRnovel0.31
UCECchr64032256Nonsense_MutationNAR247*0.34
UCECchr64052740Frame_Shift_InsnovelY781Ifs*30.38
UCECchr64052741Frame_Shift_DelNAK780Nfs*130.34
UCECchr640618913'UTRnovel0.42
UCECchr640627193'Flanknovel0.35
UCECchr640631293'Flanknovel0.57
UCECchr640647493'Flanknovel0.4
UCECchr64043891Nonsense_MutationNAR577*0.53
UCECchr64052868Missense_MutationnovelI821V0.12
UCECchr64032293Missense_MutationnovelT259I0.13
UCECchr64058815Splice_SitenovelX940_splice0.59
UCECchr64042525Missense_MutationNAA536V0.39
UCECchr640615433'UTRnovel0.3
UCECchr640646993'Flanknovel0.31
UCECchr64042525Missense_MutationNAA536V0.1
UCECchr640609643'UTRnovel0.2
UCECchr640631223'Flanknovel0.38
UCECchr640647553'Flanknovel0.19
UCECchr640617173'UTRnovel0.43
UCECchr640622783'Flanknovel0.49
UCECchr640606793'UTRnovel0.39
UCECchr640213475'UTRnovel0.5
UCECchr640607093'UTRnovel0.34
UCECchr640611643'UTRrs7540468920.2
UCECchr64032239Missense_MutationNAS241F0.37
UCECchr640614393'UTRnovel0.2
UCECchr64052740Frame_Shift_InsnovelY781Ifs*30.22
UCECchr64052741Frame_Shift_DelNAK780Nfs*130.09
UCECchr64032010Missense_MutationnovelS165P0.06
UCECchr64032595Missense_Mutationrs762252801R360C0.13
UCECchr64040816Missense_MutationNAR486Q0.37
UCECchr640615203'UTRnovel0.08
UCECchr64060431Missense_MutationnovelS947G0.38
UCECchr640610663'UTRnovel0.26
UCECchr64031644Missense_MutationNAH43Y0.22
UCECchr640618443'UTRrs7588805660.08
UCECchr64032192SilentNAS225S0.41
UCECchr64032373Missense_MutationNAR286C0.23
UCECchr64056415Missense_MutationNAF854C0.26
UCECchr64032105Nonsense_MutationnovelD197Sfs*40.07
UCECchr64031981Missense_Mutationrs777324004R155K0.53
UCECchr64032380Missense_Mutationrs368271932R288Q0.17
UCECchr64037512Missense_Mutationrs758332324R452C0.38
UCECchr64047199Missense_MutationnovelA629V0.5
UCECchr64057121Missense_MutationnovelF889L0.4
UCECchr640622423'Flanknovel0.42
UCECchr640606913'UTRnovel0.39
UCECchr64040803Nonsense_MutationNAR482*0.08
UCECchr64052741Frame_Shift_DelNAK780Nfs*130.34
UCECchr640642613'Flanknovel0.5
UCECchr640613403'UTRnovel0.38
UCECchr640621843'Flanknovel0.42
UCECchr64031871Silentrs769205716A118A0.38
UCSchr64021447Missense_MutationnovelS8A0.58

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.16670.19267
BRCADEL0.14262.197e-07
CESCDEL0.11860.046699
HNSCDEL0.12640.0011062
LIHCAMP0.37841.013e-05
LUSCDEL0.20360.00029978
PAADDEL0.30430.00010152
SARCDEL0.24510.014376
SKCMAMP0.53416.548e-09
UVMAMP0.552.0409e-06

Survival Analysis
CancerP-value Q-value
THYM0.0082

Kaplan-Meier Survival Analysis

SARC0.00081

Kaplan-Meier Survival Analysis

ACC0.029

Kaplan-Meier Survival Analysis

LUSC0.044

Kaplan-Meier Survival Analysis

BLCA0.0001

Kaplan-Meier Survival Analysis

READ0.0032

Kaplan-Meier Survival Analysis

LAML0.018

Kaplan-Meier Survival Analysis

KICH0.008

Kaplan-Meier Survival Analysis

GBM0.0037

Kaplan-Meier Survival Analysis

LIHC0.0011

Kaplan-Meier Survival Analysis

THCA0.0037

Kaplan-Meier Survival Analysis

LUAD0.025

Kaplan-Meier Survival Analysis

OV0.0044

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000112739 (Gene tree)
Gene ID
8899
Gene Symbol
PRPF4B
Alias
Prp4|PR4H|KIAA0536
Full Name
pre-mRNA processing factor 4B
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
43,717 bases
Position
chr6:4,021,267-4,064,983
Accession
17346
RBP type
non-canonical RBP
Summary
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000480058PRPF4B-2056775-ENSP000004335471007 (aa)-Q13523
ENST00000466185PRPF4B-2041297--- (aa)--
ENST00000337659PRPF4B-2014415XM_011514970ENSP000003371941007 (aa)XP_011513272Q13523
ENST00000490399PRPF4B-207576--- (aa)--
ENST00000481109PRPF4B-2062364-ENSP00000433714587 (aa)-H0YDJ3
ENST00000463634PRPF4B-2032590--- (aa)--
ENST00000461612PRPF4B-202629--- (aa)--
ENST00000494674PRPF4B-2091727--- (aa)--
ENST00000490653PRPF4B-208581--- (aa)--
Gene Model
Click here to download ENSG00000112739's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000112739Sleep9E-627126917
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000112739rs85341064057804GNight sleep phenotypes27126917[0.2-0.53] unit increase0.3658EFO_0005271
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000112739's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000112739PRPF4B10098.807ENSMUSG00000021413Prpf4b10095.040Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000398mRNA splicing, via spliceosome11991638.ICProcess
GO:0003723RNA binding22681889.HDAFunction
GO:0004672protein kinase activity21873635.IBAFunction
GO:0004674protein serine/threonine kinase activity-IEAFunction
GO:0005515protein binding15452250.16169070.17513757.17620599.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005694chromosome-IEAComponent
GO:0006468protein phosphorylation21873635.IBAProcess
GO:0008380RNA splicing9102632.TASProcess
GO:0016607nuclear speck-IDAComponent
GO:0071013catalytic step 2 spliceosome11991638.IDAComponent
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