EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30059901Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer.Redox Biol2018 SepLi Sdoi: 10.1016/j.redox.2018.07.017

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr543619100Frame_Shift_InsnovelV225Sfs*50.37
BLCAchr543649151SilentnovelL483L0.27
BLCAchr543628215Silentrs775472540E264E0.34
BLCAchr543656803Missense_MutationnovelS815C0.32
BLCAchr543650528Missense_MutationNAS553Y0.27
BLCAchr543659261Missense_MutationnovelE849K0.09
BLCAchr543644620Missense_MutationnovelH370D0.43
BLCAchr543651776Missense_MutationnovelF585L0.15
BLCAchr543613074Silentrs756010503Y106Y0.12
BLCAchr543628246Missense_MutationnovelE275Q0.1
BLCAchr543649242Missense_MutationnovelH514D0.06
BRCAchr543653098Silentrs150610196N648N0.37
BRCAchr543644755Missense_MutationNAD415H0.22
BRCAchr543704314Missense_MutationNAF1057L0.25
BRCAchr543644709Missense_MutationnovelI399M0.18
BRCAchr543619071Frame_Shift_DelNAF215Lfs*170.35
BRCAchr543702736Missense_MutationNAQ1037H0.34
CESCchr543644659Nonsense_MutationnovelQ383*0.17
CESCchr5436091545'UTRnovel0.24
CESCchr543659215Silentrs556016683V833V0.29
CESCchr543644673Silentrs747451641L387L0.15
CESCchr543644290Missense_MutationnovelE355K0.29
CESCchr543704396Nonsense_MutationnovelQ1085*0.23
CHOLchr543704359SilentnovelT1072T0.34
COADchr543644276Frame_Shift_InsnovelG351Wfs*50.04
COADchr543644277Frame_Shift_InsnovelG351Hfs*130.04
COADchr543616038Missense_Mutationrs749591680A191V0.4
COADchr543644750Missense_MutationnovelD413V0.04
COADchr543655973SilentnovelT731T0.36
COADchr543677796Frame_Shift_DelnovelV958Sfs*480.31
COADchr543645389Silentrs756650774P441P0.1
COADchr543655926Missense_MutationnovelL716F0.37
COADchr543659285In_Frame_InsnovelL857delinsQM0.05
COADchr543656650Splice_Regionnovel0.12
COADchr543702676SilentnovelQ1017Q0.09
COADchr543656773Missense_MutationnovelI805S0.11
ESCAchr543659209Missense_MutationnovelM831I0.38
GBMchr543628304Missense_MutationnovelK294R0.06
GBMchr543653076Missense_MutationnovelQ641L0.09
GBMchr543628312Missense_MutationnovelI297L0.09
GBMchr543659190Missense_MutationnovelA825D0.04
GBMchr543650541SilentNAQ557Q0.1
HNSCchr543650521Missense_MutationnovelY551H0.09
HNSCchr543628286Frame_Shift_InsnovelA289Cfs*100.43
HNSCchr543651821SilentNAL600L0.33
HNSCchr543704368SilentnovelA1075A0.12
HNSCchr543616001Missense_MutationnovelQ179E0.14
HNSCchr543616047Missense_MutationnovelS194F0.33
HNSCchr543659275SilentnovelL853L0.24
HNSCchr543656025Missense_MutationnovelG749S0.22
KICHchr543612975SilentnovelA73A0.25
KIRCchr543702713Missense_MutationNAL1030I0.35
KIRCchr543615884Missense_MutationNAH140Y0.25
KIRPchr543628258Missense_MutationnovelK279Q0.53
KIRPchr543612991Missense_Mutationrs779012961V79I0.43
KIRPchr543624059Missense_MutationnovelG239R0.24
LGGchr543613077SilentNAR107R0.47
LGGchr543609199Missense_MutationnovelA2T0.39
LGGchr543655858Missense_Mutationrs139987446R693H0.35
LGGchr543656758Missense_MutationnovelS800I0.46
LGGchr543659276Missense_MutationnovelN854Y0.33
LGGchr543649188Missense_Mutationrs749214927L496V0.39
LIHCchr543702623Missense_MutationnovelT1000A0.15
LIHCchr543644201Missense_MutationnovelA325V0.33
LIHCchr543650580SilentnovelN570N0.38
LIHCchr543649186Missense_Mutationrs199609080N495S0.34
LUADchr543645378Missense_MutationNAA438S0.39
LUADchr543613134SilentnovelV126V0.19
LUADchr543700145Missense_MutationnovelR968L0.22
LUADchr543649218Missense_MutationnovelG506C0.14
LUADchr543649219Missense_MutationnovelG506V0.14
LUADchr543675551Missense_MutationNAY892C0.14
LUADchr543628333Frame_Shift_DelnovelF304Cfs*190.1
LUADchr543656750SilentNAV797V0.15
LUADchr543649223Frame_Shift_DelnovelA508Lfs*120.25
LUADchr543649224Missense_MutationnovelA508P0.26
LUADchr543616064Missense_MutationNAG200C0.26
LUADchr543609333Silentrs139937233A46A0.18
LUADchr543659243Missense_MutationNAG843C0.25
LUADchr543644242Missense_MutationNAE339Q0.57
LUADchr543616064Missense_MutationNAG200C0.11
LUADchr543700141Missense_MutationNAG967C0.17
LUADchr543677728Missense_MutationnovelY933C0.25
LUADchr543645374Silentrs751527510F436F0.57
LUADchr543656744SilentNAF795F0.05
LUADchr543655947Missense_MutationNAI723V0.32
LUSCchr543628225Missense_MutationNAS268T0.3
LUSCchr543649283SilentNAL527L0.25
LUSCchr543656665Missense_MutationNAS769F0.17
LUSCchr543653156Missense_MutationnovelP668S0.13
LUSCchr543675544Nonsense_MutationNAG890*0.2
LUSCchr543700117Splice_SitenovelX959_splice0.18
LUSCchr543645438Missense_MutationnovelL458V0.18
LUSCchr543644689Missense_MutationnovelT393P0.12
LUSCchr543659216Missense_MutationNAV834F0.38
LUSCchr543619070Missense_Mutationrs769414431R213H0.52
LUSCchr543650525Missense_MutationNAP552L0.28
LUSCchr5437044733'UTRnovel0.28
LUSCchr543677781Missense_MutationNAL951F0.1
LUSCchr543659317Silentrs772461693S867S0.25
LUSCchr543650551Missense_MutationNAA561S0.16
LUSCchr543704274Missense_MutationNAS1044C0.07
LUSCchr543656069SilentnovelL763L0.12
LUSCchr543613082Missense_MutationnovelA109V0.29
LUSCchr543644783Missense_MutationNAR424T0.55
LUSCchr5437044103'UTRnovel0.26
LUSCchr543644659Missense_MutationnovelQ383E0.41
LUSCchr5437045703'UTRnovel0.43
OVchr543655955Missense_MutationNAE725D0.18
OVchr543659261Nonsense_MutationNAE849*0.15
OVchr543704387Nonsense_MutationnovelE1082*0.21
OVchr543656771SilentNAG804G0.16
OVchr543655983Missense_MutationNAA735T0.37
OVchr543613116SilentNAL120L0.52
OVchr543615976Frame_Shift_DelNAT172Lfs*210.71
OVchr543675632Missense_MutationNAD919V0.36
PAADchr543624105Missense_Mutationrs759627384R254Q0.04
PAADchr543609248Missense_Mutationrs12653648S18N0.13
PAADchr543651884Missense_MutationnovelQ621H0.16
PAADchr543659177Missense_MutationnovelT821S0.18
PAADchr543702671Missense_MutationnovelA1016S0.14
PAADchr5437044633'UTRnovel0.2
PAADchr5437044713'UTRnovel0.1
PRADchr543624071Missense_MutationNAA243T0.39
PRADchr543700176SilentNAA978A0.22
PRADchr543645404Missense_MutationNAQ446H0.08
READchr543704383SilentNAV1080V0.31
READchr543612996Missense_MutationnovelQ80H0.41
READchr543644648Missense_Mutationrs766059777R379Q0.36
READchr543655858Missense_Mutationrs139987446R693H0.26
SARCchr543702676SilentnovelQ1017Q0.48
SARCchr543651826Missense_MutationnovelA602V0.42
SARCchr5437044843'UTRnovel0.33
SKCMchr543650553SilentNAA561A0.44
SKCMchr543700193Missense_MutationnovelY984C0.11
SKCMchr543628224SilentNAK267K0.26
SKCMchr543645468Missense_MutationnovelP468S0.26
SKCMchr543628221SilentNAF266F0.22
SKCMchr543656040Missense_MutationNAS754R0.3
SKCMchr543659316Missense_Mutationrs748661517S867L0.35
SKCMchr543651821SilentNAL600L0.21
SKCMchr543651822Missense_MutationNAP601S0.31
SKCMchr543628242SilentNAP273P0.16
SKCMchr543649242Missense_MutationnovelH514Y0.24
SKCMchr543619047SilentNAV205V0.18
SKCMchr543613000SilentNAL82L0.24
STADchr543651827Silentrs200162492A602A0.17
STADchr5437044163'UTRnovel0.06
STADchr543644750Missense_MutationnovelD413G0.1
STADchr543619071Frame_Shift_DelNAF215Lfs*170.24
STADchr543659213Missense_MutationNAV833I0.37
STADchr543653087Missense_Mutationrs759786744R645C0.37
STADchr543613045Missense_Mutationrs751169858E97K0.3
STADchr543655894Missense_MutationnovelA705V0.1
STADchr543624041Missense_Mutationrs761727766V233I0.1
STADchr543700139Missense_MutationNAA966E0.09
STADchr543609261SilentNAS22S0.15
STADchr543609336SilentNAP47P0.04
STADchr543653205Missense_MutationNAG684D0.42
STADchr543609301Missense_MutationNAF36V0.07
STADchr543656729Silentrs371081845G790G0.29
STADchr543619104Missense_MutationNAK224N0.15
STADchr543644263SilentNAL346L0.19
STADchr543655913Silentrs373432420G711G0.26
THCAchr543616034Missense_MutationNAD190N0.12
UCECchr543645457Missense_MutationNAA464V0.51
UCECchr543644661Missense_MutationnovelQ383H0.29
UCECchr543628318Missense_MutationnovelA299T0.39
UCECchr543653088Missense_MutationNAR645H0.19
UCECchr543651769Missense_MutationnovelD583V0.24
UCECchr543609338Missense_MutationNAV48A0.43
UCECchr543645389Silentrs756650774P441P0.45
UCECchr543653052Missense_MutationnovelG633V0.36
UCECchr543656770Missense_MutationnovelG804D0.38
UCECchr543619071Frame_Shift_DelNAF215Lfs*170.13
UCECchr543650531Missense_MutationnovelT554I0.07
UCECchr543619070Missense_Mutationrs769414431R213H0.3
UCECchr543649224Missense_MutationnovelA508T0.38
UCECchr543653158SilentnovelP668P0.36
UCECchr543659296Silentrs756436246I860I0.4
UCECchr543613040Missense_MutationnovelA95V0.1
UCECchr543649254Nonsense_MutationnovelG518*0.43
UCECchr543675517Frame_Shift_DelnovelN881Ifs*70.38
UCECchr543609282Missense_MutationNAK29N0.34
UCECchr543700135Missense_MutationNAV965I0.22
UCECchr543644221Nonsense_MutationnovelE332*0.45
UCECchr543649171Missense_MutationnovelG490D0.18
UCECchr543651760Missense_MutationnovelR580I0.17
UCECchr543653190Missense_Mutationrs201010920A679V0.4
UCECchr543645389Silentrs756650774P441P0.36
UCECchr543655858Missense_Mutationrs139987446R693H0.29
UCECchr543624077Missense_MutationnovelA245T0.37
UCECchr543675611Missense_MutationnovelI912T0.38
UCECchr543653144Missense_Mutationrs371979800G664R0.53
UCECchr543704375Missense_MutationnovelA1078T0.51
UCECchr543644194Missense_MutationnovelK323Q0.48
UCECchr543619037Missense_MutationnovelK202T0.1
UCECchr5436091645'UTRnovel0.41
UCECchr543651790Frame_Shift_InsnovelE593Rfs*260.15
UCECchr543653120Missense_MutationnovelA656T0.29
UCECchr543645356Splice_SitenovelX431_splice0.39
UCECchr543653133Missense_MutationNAA660E0.13
UCECchr543650543Missense_MutationnovelG558D0.16
UCECchr543653144Missense_Mutationrs371979800G664R0.28
UCECchr543700229Missense_MutationNAD996A0.32
UCECchr543628304Missense_MutationnovelK294R0.43
UCSchr543675564SilentnovelS896S0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
COADAMP0.15960.030224
HNSCAMP0.35060.018866
LUADAMP0.50396.849e-09
LUSCAMP0.66073.0539e-09
STADAMP0.23133.3128e-05
THCADEL00.23456

Survival Analysis
CancerP-value Q-value
KIRC0.00011

Kaplan-Meier Survival Analysis

ACC0.039

Kaplan-Meier Survival Analysis

KIRP0.0041

Kaplan-Meier Survival Analysis

PCPG0.048

Kaplan-Meier Survival Analysis

READ0.011

Kaplan-Meier Survival Analysis

KICH0.013

Kaplan-Meier Survival Analysis

UCEC0.012

Kaplan-Meier Survival Analysis

LIHC0.013

Kaplan-Meier Survival Analysis

CHOL0.015

Kaplan-Meier Survival Analysis

THCA0.045

Kaplan-Meier Survival Analysis

LUAD0.0041

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000112992 (Gene tree)
Gene ID
23530
Gene Symbol
NNT
Alias
N
Full Name
nicotinamide nucleotide transhydrogenase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
104,717 bases
Position
chr5:43,602,689-43,707,405
Accession
7863
RBP type
non-canonical RBP
Summary
This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. [provided by RefSeq, Sep 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
4157116Actions of vertebrate sex hormones.Annu Rev Physiol1971Williams-Ashman HG-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000503059NNT-203634-ENSP0000042478211 (aa)-H0Y9R2
ENST00000512996NNT-2084288XM_005248275ENSP00000426343955 (aa)XP_005248332E9PCX7
ENST00000344920NNT-2024310XM_011514001ENSP000003438731086 (aa)XP_011512303Q13423
ENST00000506893NNT-206367--- (aa)--
ENST00000513390NNT-209664--- (aa)--
ENST00000512422NNT-207754-ENSP00000421886217 (aa)-D6RAI5
ENST00000515208NNT-210747-ENSP0000042554258 (aa)-D6RCR6
ENST00000503651NNT-204682-ENSP0000042167457 (aa)-H0Y8P5
ENST00000264663NNT-2016483XM_005248274ENSP000002646631086 (aa)XP_005248331Q13423
ENST00000505678NNT-205708-ENSP00000427670199 (aa)-D6RHU2
Gene Model
Click here to download ENSG00000112992's gene model file
Pathways
Pathway IDPathway NameSource
hsa00760Nicotinate and nicotinamide metabolismKEGG
hsa01100Metabolic pathwaysKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000112992Arteries5.6940000E-006-
ENSG00000112992Bronchodilator Agents1E-626634245
ENSG00000112992Lung Volume Measurements1E-626634245
ENSG00000112992Pulmonary Disease, Chronic Obstructive1E-626634245
ENSG00000112992Bronchodilator Agents1E-626634245
ENSG00000112992Lung Volume Measurements1E-626634245
ENSG00000112992Pulmonary Disease, Chronic Obstructive1E-626634245
ENSG00000112992Bronchodilator Agents1E-626634245
ENSG00000112992Lung Volume Measurements1E-626634245
ENSG00000112992Pulmonary Disease, Chronic Obstructive1E-626634245
ENSG00000112992Bronchodilator Agents1E-626634245
ENSG00000112992Lung Volume Measurements1E-626634245
ENSG00000112992Pulmonary Disease, Chronic Obstructive1E-626634245
ENSG00000112992Bronchodilator Agents1E-626634245
ENSG00000112992Lung Volume Measurements1E-626634245
ENSG00000112992Pulmonary Disease, Chronic Obstructive1E-626634245
ENSG00000112992Bronchodilator Agents2E-626634245
ENSG00000112992Lung Volume Measurements2E-626634245
ENSG00000112992Pulmonary Disease, Chronic Obstructive2E-626634245
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000112992rs192225282543672861APost bronchodilator FEV1/FVC ratio in COPD26634245NR unit increase0.074GO_0097366|EFO_0000341|EFO_0004713
ENSG00000112992rs115760645543643123GPost bronchodilator FEV1/FVC ratio in COPD26634245NR unit increase0.075GO_0097366|EFO_0000341|EFO_0004713
ENSG00000112992rs74863720543649503APost bronchodilator FEV1/FVC ratio in COPD26634245NR unit increase0.075GO_0097366|EFO_0000341|EFO_0004713
ENSG00000112992rs75999006543677651APost bronchodilator FEV1/FVC ratio in COPD26634245NR unit increase0.075GO_0097366|EFO_0000341|EFO_0004713
ENSG00000112992rs7709284543688821GPost bronchodilator FEV1/FVC ratio in COPD26634245NR unit increase0.075GO_0097366|EFO_0000341|EFO_0004713
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000112992's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000112992NNT10091.379ENSMUSG00000025453Nnt10096.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001933negative regulation of protein phosphorylation-IEAProcess
GO:0003957NAD(P)+ transhydrogenase (B-specific) activity9524818.TASFunction
GO:0005739mitochondrion21873635.IBAComponent
GO:0005739mitochondrion-IDAComponent
GO:0005743mitochondrial inner membrane10673423.TASComponent
GO:0005746mitochondrial respiratory chain10673423.TASComponent
GO:0006099tricarboxylic acid cycle10673423.TASProcess
GO:0006740NADPH regeneration21873635.IBAProcess
GO:0008746NAD(P)+ transhydrogenase activity21873635.IBAFunction
GO:0010918positive regulation of mitochondrial membrane potential-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016021integral component of membrane-IEAComponent
GO:0032364oxygen homeostasis-IEAProcess
GO:0033273response to vitamin-IEAProcess
GO:0043066negative regulation of apoptotic process-IEAProcess
GO:0045454cell redox homeostasis-IEAProcess
GO:0050661NADP binding21873635.IBAFunction
GO:0050661NADP binding10673423.IDAFunction
GO:0051287NAD binding21873635.IBAFunction
GO:0051287NAD binding10673423.TASFunction
GO:0055114oxidation-reduction process10673423.TASProcess
GO:0072593reactive oxygen species metabolic process22634753.IMPProcess
GO:0098869cellular oxidant detoxification-IEAProcess
GO:1902600proton transmembrane transport10673423.TASProcess
GO:1903285positive regulation of hydrogen peroxide catabolic process-IEAProcess
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