EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr5	90485593	Missense_Mutation	rs780251585	R9H	0.5	RNA_pol_3_Rpc31
BRCA	chr5	90506636	Missense_Mutation	rs375576885	A183T	0.11
BRCA	chr5	90487998	Splice_Site	novel	X40_splice	0.08
CESC	chr5	90485616	Missense_Mutation	NA	E17Q	0.1	RNA_pol_3_Rpc31
CESC	chr5	90512401	3'UTR	novel		0.31
CESC	chr5	90506561	Missense_Mutation	NA	D158N	0.39
COAD	chr5	90512102	Missense_Mutation	NA	A212V	0.17
COAD	chr5	90501990	Splice_Site	rs746355825	X146_splice	0.14
COAD	chr5	90485619	Missense_Mutation	novel	A18T	0.37	RNA_pol_3_Rpc31
COAD	chr5	90512360	3'UTR	novel		0.15
ESCA	chr5	90485641	Missense_Mutation	novel	E25G	0.32	RNA_pol_3_Rpc31
GBM	chr5	90495676	Splice_Site	novel	X83_splice	0.2
GBM	chr5	90506636	Missense_Mutation	rs375576885	A183T	0.38
HNSC	chr5	90506604	Missense_Mutation	novel	K172T	0.2
KIRC	chr5	90485598	Missense_Mutation	NA	A11T	0.25	RNA_pol_3_Rpc31
KIRP	chr5	90501962	Missense_Mutation	novel	T138A	0.3
LUAD	chr5	90488074	Missense_Mutation	NA	L64F	0.18	RNA_pol_3_Rpc31
LUAD	chr5	90485651	Silent	novel	P28P	0.16
LUAD	chr5	90506672	Missense_Mutation	novel	E195Q	0.16
LUSC	chr5	90485640	Missense_Mutation	NA	E25K	0.27	RNA_pol_3_Rpc31
LUSC	chr5	90512052	Splice_Site	novel	X196_splice	0.24
LUSC	chr5	90506553	Missense_Mutation	novel	E155A	0.84
MESO	chr5	90506612	Missense_Mutation	novel	D175N	0.07
OV	chr5	90512101	Missense_Mutation	rs369052283	A212T	0.09
READ	chr5	90512236	3'UTR	novel		0.38
SKCM	chr5	90485614	Missense_Mutation	NA	I16T	0.44	RNA_pol_3_Rpc31
SKCM	chr5	90497670	Missense_Mutation	rs753917944	P107S	0.45
STAD	chr5	90488015	Missense_Mutation	NA	P45S	0.33	RNA_pol_3_Rpc31
STAD	chr5	90474319	5'Flank	novel		1
STAD	chr5	90485632	Missense_Mutation	novel	S22N	0.2	RNA_pol_3_Rpc31
STAD	chr5	90501977	Frame_Shift_Del	NA	*M145Wfs90**	0.15
UCEC	chr5	90495698	Missense_Mutation	NA	R90I	0.29
UCEC	chr5	90513334	3'UTR	novel		0.25
UCEC	chr5	90512247	3'UTR	novel		0.3
UCEC	chr5	90512179	3'UTR	novel		0.24
UCEC	chr5	90485592	Missense_Mutation	rs373941949	R9C	0.1	RNA_pol_3_Rpc31
UCEC	chr5	90512543	3'UTR	novel		0.3
UCEC	chr5	90513461	3'UTR	novel		0.47
UCEC	chr5	90485538	5'UTR	novel		0.46
UCEC	chr5	90512354	3'UTR	novel		0.26
UCEC	chr5	90513249	3'UTR	novel		0.33
UCEC	chr5	90506620	Silent	rs548344039	D177D	0.25
UCEC	chr5	90512314	3'UTR	novel		0.51
UCEC	chr5	90501976	Frame_Shift_Ins	novel	*M145Nfs9**	0.32
UCEC	chr5	90501957	Missense_Mutation	novel	T136I	0.27
UCEC	chr5	90512513	3'UTR	novel		0.42
UCEC	chr5	90513577	3'UTR	novel		0.6
UCEC	chr5	90488102	Missense_Mutation	novel	F74V	0.37	RNA_pol_3_Rpc31
UCEC	chr5	90506627	Missense_Mutation	rs140910392	D180N	0.42
UCEC	chr5	90512652	3'UTR	novel		0.21
UCEC	chr5	90497699	Frame_Shift_Ins	novel	*A119Sfs19**	0.3
UCEC	chr5	90512567	3'UTR	novel		0.23
UCEC	chr5	90512100	Silent	rs769866286	G211G	0.21
UCEC	chr5	90488021	Missense_Mutation	novel	P47S	0.28	RNA_pol_3_Rpc31
UCEC	chr5	90506620	Silent	rs548344039	D177D	0.28
UCEC	chr5	90506627	Missense_Mutation	rs140910392	D180N	0.35
UCEC	chr5	90512117	Missense_Mutation	NA	N217T	0.17
UCEC	chr5	90512166	3'UTR	novel		0.5
UCEC	chr5	90512723	3'UTR	novel		0.5
UCEC	chr5	90485565	5'UTR	novel		0.07
UCEC	chr5	90513328	3'UTR	novel		0.31
UCEC	chr5	90512582	3'UTR	novel		0.28
UCEC	chr5	90513379	3'UTR	rs776488056		0.39
UCEC	chr5	90512146	3'UTR	novel		0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.1944	0.16947
LUAD	DEL	0.3004	7.4776e-05
LUSC	DEL	0.6687	0.002071
MESO	DEL	0.1379	0.20184
STAD	DEL	0.3016	2.8835e-08
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.013	Kaplan-Meier Survival Analysis
MESO	0.00054	Kaplan-Meier Survival Analysis
LUSC	0.022	Kaplan-Meier Survival Analysis
TGCT	0.046	Kaplan-Meier Survival Analysis
KIRP	0.0072	Kaplan-Meier Survival Analysis
COAD	0.029	Kaplan-Meier Survival Analysis
BLCA	0.00022	Kaplan-Meier Survival Analysis
LAML	0.0023	Kaplan-Meier Survival Analysis
KICH	0.016	Kaplan-Meier Survival Analysis
UCEC	0.046	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
LGG	0.001	Kaplan-Meier Survival Analysis
THCA	0.016	Kaplan-Meier Survival Analysis
LUAD	0.00074	Kaplan-Meier Survival Analysis
UVM	0.03	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000113356 (Gene tree)
Gene ID: 10622
Gene Symbol: POLR3G
Alias: RPC32|RPC7
Full Name: RNA polymerase III subunit G
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 42,930 bases
Position: chr5:90,471,748-90,514,677
Accession: 30075
RBP type: canonical RBP
Summary: POLR3G (RNA Polymerase III Subunit G) is a Protein Coding gene. Among its related pathways are RNA Polymerase III Transcription Initiation and Transcription of tRNA. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase III activity.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000422892	RNA_pol_3_Rpc31	PF11705.8	7.9e-32	1	1
ENSP00000382058	RNA_pol_3_Rpc31	PF11705.8	8.2e-32	1	1
ENSP00000421637	RNA_pol_3_Rpc31	PF11705.8	8.2e-32	1	1
ENSP00000422164	RNA_pol_3_Rpc31	PF11705.8	1.1e-18	1	1
ENSP00000427412	RNA_pol_3_Rpc31	PF11705.8	2.5e-15	1	1
ENSP00000425617	RNA_pol_3_Rpc31	PF11705.8	1.4e-13	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9171375	Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation.	Genes Dev	1997 May 15	Wang Z	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000504930	POLR3G-204	3251	XM_005248404	ENSP00000421637	223 (aa)	XP_005248461	O15318
ENST00000505345	POLR3G-205	581	-	ENSP00000427412	92 (aa)	-	D6RIT0
ENST00000503373	POLR3G-202	763	-	ENSP00000422892	220 (aa)	-	D6R9U7
ENST00000512239	POLR3G-206	339	-	ENSP00000424970	39 (aa)	-	D6REQ0
ENST00000514483	POLR3G-207	682	-	ENSP00000425617	100 (aa)	-	D6RJH6
ENST00000503973	POLR3G-203	583	-	ENSP00000422164	127 (aa)	-	D6R921
ENST00000399107	POLR3G-201	3285	XM_011543100	ENSP00000382058	223 (aa)	XP_011541402	O15318

Gene Model

Click here to download ENSG00000113356's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03020	RNA polymerase	KEGG
hsa04623	Cytosolic DNA-sensing pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000113356	Echocardiography	5.2096134237361E-6	17903301
ENSG00000113356	Platelet Function Tests	1.2824000E-005	-
ENSG00000113356	Reverse Transcriptase Inhibitors	5E-6	21810746

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000113356	rs2562519	5	90485154	A	Nevirapine-induced rash	21810746			GO_0061479

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113356's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000113356	POLR3G	100	100.000	ENSANAG00000005030	POLR3G	100	97.758	Aotus_nancymaae
ENSG00000113356	POLR3G	100	95.652	ENSCJAG00000023264	-	87	89.671	Callithrix_jacchus
ENSG00000113356	POLR3G	100	100.000	ENSCCAG00000032288	POLR3G	100	97.758	Cebus_capucinus
ENSG00000113356	POLR3G	100	100.000	ENSCANG00000009341	-	99	94.000	Colobus_angolensis_palliatus
ENSG00000113356	POLR3G	100	100.000	ENSGGOG00000000266	POLR3G	100	100.000	Gorilla_gorilla
ENSG00000113356	POLR3G	100	92.308	ENSJJAG00000012853	-	93	90.805	Jaculus_jaculus
ENSG00000113356	POLR3G	100	100.000	ENSMFAG00000028791	POLR3G	100	97.758	Macaca_fascicularis
ENSG00000113356	POLR3G	100	100.000	ENSMMUG00000018972	POLR3G	100	97.309	Macaca_mulatta
ENSG00000113356	POLR3G	100	100.000	ENSMNEG00000029715	POLR3G	100	97.758	Macaca_nemestrina
ENSG00000113356	POLR3G	100	100.000	ENSMLEG00000028512	POLR3G	100	97.758	Mandrillus_leucophaeus
ENSG00000113356	POLR3G	100	97.436	ENSMPUG00000007905	-	99	74.890	Mustela_putorius_furo
ENSG00000113356	POLR3G	100	100.000	ENSPPAG00000038891	POLR3G	100	96.413	Pan_paniscus
ENSG00000113356	POLR3G	100	100.000	ENSPTRG00000017068	POLR3G	100	100.000	Pan_troglodytes
ENSG00000113356	POLR3G	100	100.000	ENSPANG00000006211	POLR3G	100	97.309	Papio_anubis
ENSG00000113356	POLR3G	100	100.000	ENSPPYG00000015624	POLR3G	100	97.758	Pongo_abelii
ENSG00000113356	POLR3G	100	100.000	ENSRBIG00000040918	POLR3G	100	97.309	Rhinopithecus_bieti
ENSG00000113356	POLR3G	100	100.000	ENSRROG00000041507	POLR3G	100	97.309	Rhinopithecus_roxellana
ENSG00000113356	POLR3G	100	94.872	ENSSBOG00000025588	-	98	86.047	Saimiri_boliviensis_boliviensis
ENSG00000113356	POLR3G	100	98.913	ENSSBOG00000029447	-	100	96.413	Saimiri_boliviensis_boliviensis
ENSG00000113356	POLR3G	100	97.436	ENSSBOG00000029581	-	96	98.876	Saimiri_boliviensis_boliviensis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0000790	nuclear chromatin	24107381.	IDA	Component
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	-	IEA	Function
GO:0005515	protein binding	20154270.21358628.	IPI	Function
GO:0005634	nucleus	20154270.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005666	RNA polymerase III complex	21873635.	IBA	Component
GO:0005666	RNA polymerase III complex	24107381.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006359	regulation of transcription by RNA polymerase III	9171375.	TAS	Process
GO:0006383	transcription by RNA polymerase III	20154270.	IDA	Process
GO:0008283	cell proliferation	21873635.	IBA	Process
GO:0008283	cell proliferation	24107381.	IEP	Process
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0032728	positive regulation of interferon-beta production	19609254.19631370.	IMP	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0045089	positive regulation of innate immune response	19609254.19631370.	IMP	Process
GO:0051607	defense response to virus	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.