EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27031502Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics.PLoS One2016 Mar 31Okerberg ESdoi: 10.1371/journal.pone.0152934
22350414MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling.Cancer Res2012 Apr 1Zhang Pdoi: 10.1158/0008-5472.CAN-11-3027
29593330CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy.Nat Cell Biol2018 AprCai Jdoi: 10.1038/s41556-018-0065-8
16880514Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells.Mol Cell Biol2006 AugDejmek J-
25798617Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.J Clin Invest2015 AprCheong JKdoi: 10.1172/JCI78018
26984280The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation.Elife2016 Mar 17Lin TCdoi: 10.7554/eLife.11288.
27686097HIF-2α phosphorylation by CK1?? promotes erythropoietin secretion in liver cancer cells under hypoxia.J Cell Sci2016 Nov 15Pangou E-
29409464CK1α overexpression correlates with poor survival in colorectal cancer.BMC Cancer2018 Feb 6Richter Jdoi: 10.1186/s12885-018-4019-0.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr5149550086SilentnovelI73I0.38
BLCAchr5149525152Missense_MutationNAD84N0.27
BLCAchr5149550122Missense_MutationNAS61R0.08
BLCAchr5149550873Missense_MutationnovelI31N0.45
BLCAchr5149550844Missense_MutationNAE41K0.57
BLCAchr5149505586Missense_MutationnovelN289K0.15
BLCAchr5149550146Frame_Shift_DelnovelR53Sfs*360.18
BRCAchr5149513173In_Frame_InsnovelY164_R165insP0.09
BRCAchr51494968133'UTRnovel0.38
BRCAchr51494957933'Flanknovel0.27
BRCAchr5149505523SilentNAA310A0.36
BRCAchr51494966863'UTRnovel0.23
BRCAchr5149550127Missense_MutationNAE60K0.21
BRCAchr51495510085'UTRnovel0.29
BRCAchr5149550937Nonsense_MutationNAE10*0.53
BRCAchr51494957773'Flanknovel0.08
CESCchr51494961553'UTRnovel0.27
CESCchr5149520356SilentnovelK130K0.27
COADchr5149505438Intronnovel0.33
COADchr5149550903Missense_MutationNAR21L0.35
COADchr5149507039Missense_MutationNAR282H0.32
COADchr51494967683'UTRnovel0.46
COADchr5149507114Missense_MutationNAA257V0.4
COADchr5149550089SilentNAG72G0.42
DLBCchr5149550885Missense_MutationNAS27C0.95
ESCAchr51494961553'UTRnovel0.13
ESCAchr51494964713'UTRnovel0.33
ESCAchr51495510305'UTRnovel0.46
ESCAchr5149520297Missense_MutationnovelC150Y0.63
ESCAchr5149520313Missense_MutationnovelG145S0.76
ESCAchr51494959663'UTRnovel0.49
GBMchr5149550167Silentrs760677105K46K0.29
GBMchr5149550930Missense_MutationnovelI12N0.16
HNSCchr5149513070Frame_Shift_DelnovelE197Vfs*90.08
HNSCchr51495510295'UTRnovel0.19
HNSCchr5149550210Intronnovel0.44
HNSCchr5149550245Intronnovel0.5
HNSCchr5149520390Splice_SitenovelX120_splice0.41
KIRCchr5149517851Intronnovel0.04
KIRCchr5149517852Intronnovel0.02
KIRCchr5149525115Missense_MutationNAS96I0.26
LAMLchr5149505578Missense_MutationNAY292C0.05
LGGchr5149505459Missense_MutationnovelS332R0.37
LGGchr5149520303Missense_MutationnovelR148H0.5
LIHCchr5149550210Intronnovel0.35
LIHCchr5149550160Missense_MutationnovelS49P0.14
LUADchr5149550877Frame_Shift_DelnovelD30Tfs*160.44
LUADchr5149550893Silentrs766766571G24G0.23
LUADchr5149507072Missense_MutationnovelA271V0.15
LUSCchr5149550844Nonsense_MutationNAE41*0.7
LUSCchr5149525169Nonsense_MutationnovelW78*0.77
OVchr51495510035'UTRnovel0.11
OVchr5149550202Intronnovel0.04
OVchr5149550203Intronnovel0.02
OVchr5149550083SilentNAP74P0.04
READchr51494967243'UTRnovel0.24
SARCchr5149550150Missense_MutationnovelA52D0.14
SKCMchr5149550165Missense_MutationNAL47P0.24
SKCMchr5149550884Silentrs112881076S27S0.18
SKCMchr5149550885Missense_MutationNAS27F0.18
SKCMchr5149525115Missense_MutationNAS96I0.47
SKCMchr5149525116Missense_MutationnovelS96C0.47
SKCMchr5149513086Missense_MutationnovelL194F0.27
STADchr5149505495Missense_MutationNAQ320E0.38
STADchr5149505473Missense_MutationnovelT327I0.4
STADchr5149511868Nonsense_MutationNAR201*0.71
UCECchr51494958093'Flanknovel0.26
UCECchr5149511868Nonsense_MutationNAR201*0.29
UCECchr5149517871IntronNA0.24
UCECchr51494961553'UTRnovel0.45
UCECchr51494959273'UTRnovel0.35
UCECchr5149509900Silentrs377108745T243T0.32
UCECchr5149520324Missense_MutationnovelN141T0.32
UCECchr51494957573'Flanknovel0.44
UCECchr51494968003'UTRnovel0.29
UCECchr5149507094Missense_MutationnovelR264C0.43
UCECchr51494960553'UTRnovel0.3
UCECchr51495511115'UTRnovel0.32
UCECchr51494961553'UTRnovel0.65
UCECchr5149509901Missense_MutationnovelT243M0.21
UCECchr51494961723'UTRnovel0.32
UCECchr5149550270Intronnovel0.44
UCECchr51494965663'UTRnovel0.47
UCECchr51495509925'UTRnovel0.26
UCECchr5149550200Intronnovel0.42
UCECchr51494961553'UTRnovel0.37
UCECchr51494957583'Flanknovel0.44
UCECchr51494961553'UTRnovel0.46
UCECchr51494961553'UTRnovel0.61
UCECchr5149550146SilentnovelR53R0.29
UCECchr51494959663'UTRnovel0.38
UCECchr51494961083'UTRnovel0.35
UCECchr5149517793Intronnovel0.4
UCECchr51494959963'UTRnovel0.49
UCECchr5149550888Missense_MutationnovelG26D0.39
UCECchr5149507064Missense_MutationNAY274H0.47
UCECchr5149505478SilentnovelK325K0.09
UCECchr51494961553'UTRnovel0.45
UCECchr51494963743'UTRnovel0.33
UCECchr5149550161Missense_MutationnovelE48D0.1
UCECchr51494961553'UTRnovel0.36
UCECchr5149505546Nonsense_MutationnovelQ303*0.24
UCECchr51494957573'Flanknovel0.57
UCECchr51494959113'UTRnovel0.19
UCECchr5149520366Missense_MutationnovelV127A0.29
UCECchr51495512585'UTRnovel0.44
UCECchr5149513172Frame_Shift_InsnovelR165Kfs*150.04
UCECchr5149513174In_Frame_InsnovelY164_R165insFPP0.04
UCECchr51494964703'UTRnovel0.45
UCECchr5149525110Missense_MutationNAE98K0.29
UCECchr5149550935Missense_MutationnovelE10D0.34
UCECchr51494959273'UTRnovel0.07
UCECchr5149525111SilentnovelL97L0.48
UCECchr51494967243'UTRnovel0.3
UCECchr5149511867Missense_MutationnovelR201Q0.22
UCECchr5149520351Missense_MutationnovelF132C0.12
UCECchr51494958893'Flanknovel0.34
UCECchr5149520302SilentnovelR148R0.26
UCECchr51494963133'UTRnovel0.33
UCECchr51494961553'UTRnovel0.29
UCECchr51494958093'Flanknovel0.43
UCECchr5149507114Missense_MutationNAA257V0.44
UCECchr5149520340Missense_MutationNAD136Y0.17
UCECchr51494959663'UTRnovel0.39
UCECchr5149507113Silentrs769413851A257A0.28
UCECchr5149513107Missense_MutationnovelY187H0.44
UCECchr51494961553'UTRnovel0.41
UCECchr51494961553'UTRnovel0.5

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPAMP0.10420.069756
KIRPDEL0.03820.11554
LAMLDEL0.0891.2971e-07
LUSCDEL0.62080.002071
MESODEL0.13790.20184
PRADAMP0.02640.16448
SKCMDEL0.28882.2081e-08
THCAAMP0.03610.075436
THCADEL00.23456

Survival Analysis
CancerP-value Q-value
KIRC0.0051

Kaplan-Meier Survival Analysis

PRAD0.038

Kaplan-Meier Survival Analysis

BRCA0.015

Kaplan-Meier Survival Analysis

COAD0.017

Kaplan-Meier Survival Analysis

PAAD0.0015

Kaplan-Meier Survival Analysis

PCPG0.021

Kaplan-Meier Survival Analysis

CESC0.04

Kaplan-Meier Survival Analysis

READ0.038

Kaplan-Meier Survival Analysis

KICH0.037

Kaplan-Meier Survival Analysis

LIHC0.0094

Kaplan-Meier Survival Analysis

LGG0.01

Kaplan-Meier Survival Analysis

UVM0.0059

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000113712 (Gene tree)
Gene ID
1452
Gene Symbol
CSNK1A1
Alias
CK1|CK1a|CK1alpha|CKIa|CKIalpha
Full Name
casein kinase 1 alpha 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
59,356 bases
Position
chr5:149,492,197-149,551,552
Accession
2451
RBP type
non-canonical RBP
Summary
(Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are T41 mutants of beta-catenin arent phosphorylated and mTOR signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1A1L.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000606826CSNK1A1-211800-ENSP00000475969184 (aa)-U3KQK7
ENST00000377843CSNK1A1-2022559-ENSP00000367074337 (aa)-P48729
ENST00000606719CSNK1A1-210835-ENSP00000475319134 (aa)-U3KPX3
ENST00000503350CSNK1A1-2031099-ENSP00000425366167 (aa)-H0Y9X2
ENST00000523203CSNK1A1-208775-ENSP0000043025278 (aa)-E5RG27
ENST00000606299CSNK1A1-2091075-ENSP0000047563396 (aa)-U3KQ83
ENST00000515768CSNK1A1-2071098-ENSP00000421689365 (aa)-P48729
ENST00000504676CSNK1A1-2041772-ENSP00000426747236 (aa)-D6REM4
ENST00000515435CSNK1A1-2051856-ENSP00000427031264 (aa)-E7ETM0
ENST00000261798CSNK1A1-2016067-ENSP00000261798325 (aa)-P48729
ENST00000515748CSNK1A1-206620-ENSP0000042126889 (aa)-D6RGE5
Gene Model
Click here to download ENSG00000113712's gene model file
Pathways
Pathway IDPathway NameSource
hsa04310Wnt signaling pathwayKEGG
hsa04340Hedgehog signaling pathwayKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05224Breast cancerKEGG
hsa05225Hepatocellular carcinomaKEGG
hsa05226Gastric cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000113712Esophageal Neoplasms5E-921642993
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000113712rs100587285149524529TEsophageal cancer21642993[1.61-2.56]2.04EFO_0002916
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113712's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000113712CSNK1A19889.655WBGene00002202kin-199286.984Caenorhabditis_elegans
ENSG00000113712CSNK1A1100100.000ENSMUSG00000024576Csnk1a1100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000777condensed chromosome kinetochore-IEAComponent
GO:0000902cell morphogenesis-IEAProcess
GO:0004672protein kinase activity-ISSFunction
GO:0004672protein kinase activity10777483.TASFunction
GO:0004674protein serine/threonine kinase activity21873635.IBAFunction
GO:0004674protein serine/threonine kinase activity18305108.25500533.IDAFunction
GO:0004674protein serine/threonine kinase activity11955436.IMPFunction
GO:0004674protein serine/threonine kinase activity-TASFunction
GO:0005515protein binding16511560.17110929.18067272.18305108.19118383.20708156.23902688.26131937.26909574.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005813centrosome21399614.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005847mRNA cleavage and polyadenylation specificity factor complex18305108.IDAComponent
GO:0005929cilium-TASComponent
GO:0006468protein phosphorylation18305108.IDAProcess
GO:0007030Golgi organization25500533.IMPProcess
GO:0007049cell cycle-IEAProcess
GO:0007165signal transduction10777483.NASProcess
GO:0007166cell surface receptor signaling pathway10777483.TASProcess
GO:0016020membrane19946888.HDAComponent
GO:0016055Wnt signaling pathway21873635.IBAProcess
GO:0016055Wnt signaling pathway-TASProcess
GO:0016301kinase activity-TASFunction
GO:0016607nuclear speck18305108.IDAComponent
GO:0018105peptidyl-serine phosphorylation21873635.IBAProcess
GO:0018105peptidyl-serine phosphorylation25500533.IDAProcess
GO:0018105peptidyl-serine phosphorylation11955436.IMPProcess
GO:0018107peptidyl-threonine phosphorylation21873635.IBAProcess
GO:0030877beta-catenin destruction complex11955436.IDAComponent
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process21873635.IBAProcess
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process11955436.IMPProcess
GO:0036064ciliary basal body-ISSComponent
GO:0045095keratin filament23902688.IDAComponent
GO:0045104intermediate filament cytoskeleton organization23902688.IMPProcess
GO:0051301cell division-IEAProcess
GO:0090090negative regulation of canonical Wnt signaling pathway21873635.IBAProcess
GO:0090090negative regulation of canonical Wnt signaling pathway11955436.ICProcess
GO:0090090negative regulation of canonical Wnt signaling pathway21331045.IMPProcess
GO:1904424regulation of GTP binding25500533.IMPProcess
GO:1904885beta-catenin destruction complex assembly-TASProcess
GO:1904886beta-catenin destruction complex disassembly-TASProcess
GO:1990904ribonucleoprotein complex-IEAComponent
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