EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27031502	Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics.	PLoS One	2016 Mar 31	Okerberg ES	doi: 10.1371/journal.pone.0152934
22350414	MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling.	Cancer Res	2012 Apr 1	Zhang P	doi: 10.1158/0008-5472.CAN-11-3027
29593330	CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy.	Nat Cell Biol	2018 Apr	Cai J	doi: 10.1038/s41556-018-0065-8
16880514	Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells.	Mol Cell Biol	2006 Aug	Dejmek J	-
25798617	Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.	J Clin Invest	2015 Apr	Cheong JK	doi: 10.1172/JCI78018
26984280	The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation.	Elife	2016 Mar 17	Lin TC	doi: 10.7554/eLife.11288.
27686097	HIF-2α phosphorylation by CK1?? promotes erythropoietin secretion in liver cancer cells under hypoxia.	J Cell Sci	2016 Nov 15	Pangou E	-
29409464	CK1α overexpression correlates with poor survival in colorectal cancer.	BMC Cancer	2018 Feb 6	Richter J	doi: 10.1186/s12885-018-4019-0.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr5	149550086	Silent	novel	I73I	0.38
BLCA	chr5	149525152	Missense_Mutation	NA	D84N	0.27
BLCA	chr5	149550122	Missense_Mutation	NA	S61R	0.08
BLCA	chr5	149550873	Missense_Mutation	novel	I31N	0.45
BLCA	chr5	149550844	Missense_Mutation	NA	E41K	0.57
BLCA	chr5	149505586	Missense_Mutation	novel	N289K	0.15
BLCA	chr5	149550146	Frame_Shift_Del	novel	*R53Sfs36**	0.18
BRCA	chr5	149513173	In_Frame_Ins	novel	Y164_R165insP	0.09
BRCA	chr5	149496813	3'UTR	novel		0.38
BRCA	chr5	149495793	3'Flank	novel		0.27
BRCA	chr5	149505523	Silent	NA	A310A	0.36
BRCA	chr5	149496686	3'UTR	novel		0.23
BRCA	chr5	149550127	Missense_Mutation	NA	E60K	0.21
BRCA	chr5	149551008	5'UTR	novel		0.29
BRCA	chr5	149550937	Nonsense_Mutation	NA	E10*	0.53
BRCA	chr5	149495777	3'Flank	novel		0.08
CESC	chr5	149496155	3'UTR	novel		0.27
CESC	chr5	149520356	Silent	novel	K130K	0.27
COAD	chr5	149505438	Intron	novel		0.33
COAD	chr5	149550903	Missense_Mutation	NA	R21L	0.35
COAD	chr5	149507039	Missense_Mutation	NA	R282H	0.32
COAD	chr5	149496768	3'UTR	novel		0.46
COAD	chr5	149507114	Missense_Mutation	NA	A257V	0.4
COAD	chr5	149550089	Silent	NA	G72G	0.42
DLBC	chr5	149550885	Missense_Mutation	NA	S27C	0.95
ESCA	chr5	149496155	3'UTR	novel		0.13
ESCA	chr5	149496471	3'UTR	novel		0.33
ESCA	chr5	149551030	5'UTR	novel		0.46
ESCA	chr5	149520297	Missense_Mutation	novel	C150Y	0.63
ESCA	chr5	149520313	Missense_Mutation	novel	G145S	0.76
ESCA	chr5	149495966	3'UTR	novel		0.49
GBM	chr5	149550167	Silent	rs760677105	K46K	0.29
GBM	chr5	149550930	Missense_Mutation	novel	I12N	0.16
HNSC	chr5	149513070	Frame_Shift_Del	novel	*E197Vfs9**	0.08
HNSC	chr5	149551029	5'UTR	novel		0.19
HNSC	chr5	149550210	Intron	novel		0.44
HNSC	chr5	149550245	Intron	novel		0.5
HNSC	chr5	149520390	Splice_Site	novel	X120_splice	0.41
KIRC	chr5	149517851	Intron	novel		0.04
KIRC	chr5	149517852	Intron	novel		0.02
KIRC	chr5	149525115	Missense_Mutation	NA	S96I	0.26
LAML	chr5	149505578	Missense_Mutation	NA	Y292C	0.05
LGG	chr5	149505459	Missense_Mutation	novel	S332R	0.37
LGG	chr5	149520303	Missense_Mutation	novel	R148H	0.5
LIHC	chr5	149550210	Intron	novel		0.35
LIHC	chr5	149550160	Missense_Mutation	novel	S49P	0.14
LUAD	chr5	149550877	Frame_Shift_Del	novel	*D30Tfs16**	0.44
LUAD	chr5	149550893	Silent	rs766766571	G24G	0.23
LUAD	chr5	149507072	Missense_Mutation	novel	A271V	0.15
LUSC	chr5	149550844	Nonsense_Mutation	NA	E41*	0.7
LUSC	chr5	149525169	Nonsense_Mutation	novel	W78*	0.77
OV	chr5	149551003	5'UTR	novel		0.11
OV	chr5	149550202	Intron	novel		0.04
OV	chr5	149550203	Intron	novel		0.02
OV	chr5	149550083	Silent	NA	P74P	0.04
READ	chr5	149496724	3'UTR	novel		0.24
SARC	chr5	149550150	Missense_Mutation	novel	A52D	0.14
SKCM	chr5	149550165	Missense_Mutation	NA	L47P	0.24
SKCM	chr5	149550884	Silent	rs112881076	S27S	0.18
SKCM	chr5	149550885	Missense_Mutation	NA	S27F	0.18
SKCM	chr5	149525115	Missense_Mutation	NA	S96I	0.47
SKCM	chr5	149525116	Missense_Mutation	novel	S96C	0.47
SKCM	chr5	149513086	Missense_Mutation	novel	L194F	0.27
STAD	chr5	149505495	Missense_Mutation	NA	Q320E	0.38
STAD	chr5	149505473	Missense_Mutation	novel	T327I	0.4
STAD	chr5	149511868	Nonsense_Mutation	NA	R201*	0.71
UCEC	chr5	149495809	3'Flank	novel		0.26
UCEC	chr5	149511868	Nonsense_Mutation	NA	R201*	0.29
UCEC	chr5	149517871	Intron	NA		0.24
UCEC	chr5	149496155	3'UTR	novel		0.45
UCEC	chr5	149495927	3'UTR	novel		0.35
UCEC	chr5	149509900	Silent	rs377108745	T243T	0.32
UCEC	chr5	149520324	Missense_Mutation	novel	N141T	0.32
UCEC	chr5	149495757	3'Flank	novel		0.44
UCEC	chr5	149496800	3'UTR	novel		0.29
UCEC	chr5	149507094	Missense_Mutation	novel	R264C	0.43
UCEC	chr5	149496055	3'UTR	novel		0.3
UCEC	chr5	149551111	5'UTR	novel		0.32
UCEC	chr5	149496155	3'UTR	novel		0.65
UCEC	chr5	149509901	Missense_Mutation	novel	T243M	0.21
UCEC	chr5	149496172	3'UTR	novel		0.32
UCEC	chr5	149550270	Intron	novel		0.44
UCEC	chr5	149496566	3'UTR	novel		0.47
UCEC	chr5	149550992	5'UTR	novel		0.26
UCEC	chr5	149550200	Intron	novel		0.42
UCEC	chr5	149496155	3'UTR	novel		0.37
UCEC	chr5	149495758	3'Flank	novel		0.44
UCEC	chr5	149496155	3'UTR	novel		0.46
UCEC	chr5	149496155	3'UTR	novel		0.61
UCEC	chr5	149550146	Silent	novel	R53R	0.29
UCEC	chr5	149495966	3'UTR	novel		0.38
UCEC	chr5	149496108	3'UTR	novel		0.35
UCEC	chr5	149517793	Intron	novel		0.4
UCEC	chr5	149495996	3'UTR	novel		0.49
UCEC	chr5	149550888	Missense_Mutation	novel	G26D	0.39
UCEC	chr5	149507064	Missense_Mutation	NA	Y274H	0.47
UCEC	chr5	149505478	Silent	novel	K325K	0.09
UCEC	chr5	149496155	3'UTR	novel		0.45
UCEC	chr5	149496374	3'UTR	novel		0.33
UCEC	chr5	149550161	Missense_Mutation	novel	E48D	0.1
UCEC	chr5	149496155	3'UTR	novel		0.36
UCEC	chr5	149505546	Nonsense_Mutation	novel	Q303*	0.24
UCEC	chr5	149495757	3'Flank	novel		0.57
UCEC	chr5	149495911	3'UTR	novel		0.19
UCEC	chr5	149520366	Missense_Mutation	novel	V127A	0.29
UCEC	chr5	149551258	5'UTR	novel		0.44
UCEC	chr5	149513172	Frame_Shift_Ins	novel	*R165Kfs15**	0.04
UCEC	chr5	149513174	In_Frame_Ins	novel	Y164_R165insFPP	0.04
UCEC	chr5	149496470	3'UTR	novel		0.45
UCEC	chr5	149525110	Missense_Mutation	NA	E98K	0.29
UCEC	chr5	149550935	Missense_Mutation	novel	E10D	0.34
UCEC	chr5	149495927	3'UTR	novel		0.07
UCEC	chr5	149525111	Silent	novel	L97L	0.48
UCEC	chr5	149496724	3'UTR	novel		0.3
UCEC	chr5	149511867	Missense_Mutation	novel	R201Q	0.22
UCEC	chr5	149520351	Missense_Mutation	novel	F132C	0.12
UCEC	chr5	149495889	3'Flank	novel		0.34
UCEC	chr5	149520302	Silent	novel	R148R	0.26
UCEC	chr5	149496313	3'UTR	novel		0.33
UCEC	chr5	149496155	3'UTR	novel		0.29
UCEC	chr5	149495809	3'Flank	novel		0.43
UCEC	chr5	149507114	Missense_Mutation	NA	A257V	0.44
UCEC	chr5	149520340	Missense_Mutation	NA	D136Y	0.17
UCEC	chr5	149495966	3'UTR	novel		0.39
UCEC	chr5	149507113	Silent	rs769413851	A257A	0.28
UCEC	chr5	149513107	Missense_Mutation	novel	Y187H	0.44
UCEC	chr5	149496155	3'UTR	novel		0.41
UCEC	chr5	149496155	3'UTR	novel		0.5

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	AMP	0.1042	0.069756
KIRP	DEL	0.0382	0.11554
LAML	DEL	0.089	1.2971e-07
LUSC	DEL	0.6208	0.002071
MESO	DEL	0.1379	0.20184
PRAD	AMP	0.0264	0.16448
SKCM	DEL	0.2888	2.2081e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0051	Kaplan-Meier Survival Analysis
PRAD	0.038	Kaplan-Meier Survival Analysis
BRCA	0.015	Kaplan-Meier Survival Analysis
COAD	0.017	Kaplan-Meier Survival Analysis
PAAD	0.0015	Kaplan-Meier Survival Analysis
PCPG	0.021	Kaplan-Meier Survival Analysis
CESC	0.04	Kaplan-Meier Survival Analysis
READ	0.038	Kaplan-Meier Survival Analysis
KICH	0.037	Kaplan-Meier Survival Analysis
LIHC	0.0094	Kaplan-Meier Survival Analysis
LGG	0.01	Kaplan-Meier Survival Analysis
UVM	0.0059	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000113712 (Gene tree)
Gene ID: 1452
Gene Symbol: CSNK1A1
Alias: CK1|CK1a|CK1alpha|CKIa|CKIalpha
Full Name: casein kinase 1 alpha 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 59,356 bases
Position: chr5:149,492,197-149,551,552
Accession: 2451
RBP type: non-canonical RBP
Summary: (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are T41 mutants of beta-catenin arent phosphorylated and mTOR signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1A1L.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000606826	CSNK1A1-211	800	-	ENSP00000475969	184 (aa)	-	U3KQK7
ENST00000377843	CSNK1A1-202	2559	-	ENSP00000367074	337 (aa)	-	P48729
ENST00000606719	CSNK1A1-210	835	-	ENSP00000475319	134 (aa)	-	U3KPX3
ENST00000503350	CSNK1A1-203	1099	-	ENSP00000425366	167 (aa)	-	H0Y9X2
ENST00000523203	CSNK1A1-208	775	-	ENSP00000430252	78 (aa)	-	E5RG27
ENST00000606299	CSNK1A1-209	1075	-	ENSP00000475633	96 (aa)	-	U3KQ83
ENST00000515768	CSNK1A1-207	1098	-	ENSP00000421689	365 (aa)	-	P48729
ENST00000504676	CSNK1A1-204	1772	-	ENSP00000426747	236 (aa)	-	D6REM4
ENST00000515435	CSNK1A1-205	1856	-	ENSP00000427031	264 (aa)	-	E7ETM0
ENST00000261798	CSNK1A1-201	6067	-	ENSP00000261798	325 (aa)	-	P48729
ENST00000515748	CSNK1A1-206	620	-	ENSP00000421268	89 (aa)	-	D6RGE5

Gene Model

Click here to download ENSG00000113712's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04310	Wnt signaling pathway	KEGG
hsa04340	Hedgehog signaling pathway	KEGG
hsa05165	Human papillomavirus infection	KEGG
hsa05224	Breast cancer	KEGG
hsa05225	Hepatocellular carcinoma	KEGG
hsa05226	Gastric cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000113712	Esophageal Neoplasms	5E-9	21642993

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000113712	rs10058728	5	149524529	T	Esophageal cancer	21642993	[1.61-2.56]	2.04	EFO_0002916

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113712's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000113712	CSNK1A1	98	89.655	WBGene00002202	kin-19	92	86.984	Caenorhabditis_elegans
ENSG00000113712	CSNK1A1	100	100.000	ENSMUSG00000024576	Csnk1a1	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0000902	cell morphogenesis	-	IEA	Process
GO:0004672	protein kinase activity	-	ISS	Function
GO:0004672	protein kinase activity	10777483.	TAS	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	18305108.25500533.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	11955436.	IMP	Function
GO:0004674	protein serine/threonine kinase activity	-	TAS	Function
GO:0005515	protein binding	16511560.17110929.18067272.18305108.19118383.20708156.23902688.26131937.26909574.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005813	centrosome	21399614.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	18305108.	IDA	Component
GO:0005929	cilium	-	TAS	Component
GO:0006468	protein phosphorylation	18305108.	IDA	Process
GO:0007030	Golgi organization	25500533.	IMP	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007165	signal transduction	10777483.	NAS	Process
GO:0007166	cell surface receptor signaling pathway	10777483.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016055	Wnt signaling pathway	21873635.	IBA	Process
GO:0016055	Wnt signaling pathway	-	TAS	Process
GO:0016301	kinase activity	-	TAS	Function
GO:0016607	nuclear speck	18305108.	IDA	Component
GO:0018105	peptidyl-serine phosphorylation	21873635.	IBA	Process
GO:0018105	peptidyl-serine phosphorylation	25500533.	IDA	Process
GO:0018105	peptidyl-serine phosphorylation	11955436.	IMP	Process
GO:0018107	peptidyl-threonine phosphorylation	21873635.	IBA	Process
GO:0030877	beta-catenin destruction complex	11955436.	IDA	Component
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	11955436.	IMP	Process
GO:0036064	ciliary basal body	-	ISS	Component
GO:0045095	keratin filament	23902688.	IDA	Component
GO:0045104	intermediate filament cytoskeleton organization	23902688.	IMP	Process
GO:0051301	cell division	-	IEA	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	21873635.	IBA	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	11955436.	IC	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	21331045.	IMP	Process
GO:1904424	regulation of GTP binding	25500533.	IMP	Process
GO:1904885	beta-catenin destruction complex assembly	-	TAS	Process
GO:1904886	beta-catenin destruction complex disassembly	-	TAS	Process
GO:1990904	ribonucleoprotein complex	-	IEA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.