EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28865028Drebrin at Junctional Plaques.Adv Exp Med Biol2017Ludwig-Peitsch WKdoi: 10.1007/978-4-431-56550-5_18.
24346822Expression of drebrin, an actin binding protein, in basal cell carcinoma, trichoblastoma and trichoepithelioma.Histol Histopathol2014 JunMizutani Ydoi: 10.14670/HH-29.757
28865033The Role of Drebrin in Cancer Cell Invasion.Adv Exp Med Biol2017Dart AEdoi: 10.1007/978-4-431-56550-5_23.
28865011General Introduction to Drebrin.Adv Exp Med Biol2017Shirao Tdoi: 10.1007/978-4-431-56550-5_1.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr5177458467Missense_Mutationrs775591763D456A0.2
ACCchr5177467040Missense_MutationnovelE193A0.08
BLCAchr5177458267Missense_MutationnovelA523T0.17
BLCAchr5177458083Missense_MutationNAE584G0.21
BLCAchr5177457748Frame_Shift_DelnovelS594Vfs*530.08
BLCAchr5177460462Missense_MutationnovelD309Y0.39
BLCAchr5177460531SilentnovelR286R0.46
BRCAchr5177458520SilentnovelP438P0.39
BRCAchr5177458420Missense_Mutationrs151027179A472T0.25
BRCAchr5177458609Missense_MutationNAA409T0.43
BRCAchr5177466963Missense_MutationnovelE219Q0.26
BRCAchr5177468199Missense_Mutationrs558662294S55L0.12
BRCAchr51774573973'UTRrs3749305810.31
BRCAchr5177458057Splice_SiteNAX592_splice0.64
BRCAchr5177458084Missense_MutationNAE584K0.5
BRCAchr5177472138Intronnovel0.18
BRCAchr5177472139Intronnovel0.18
BRCAchr5177467045SilentnovelR191R0.08
CESCchr5177459202Missense_MutationNAS341F0.32
CESCchr5177457661Missense_MutationnovelP625S0.14
CESCchr5177457463Missense_MutationnovelE640D0.06
CESCchr51774567733'UTRnovel0.32
CESCchr5177458420Missense_Mutationrs151027179A472T0.19
CESCchr5177460487Silentrs528266629V300V0.07
CESCchr5177467311Missense_MutationNAD167H0.2
CESCchr5177458388Silentrs370979617N482N0.37
CESCchr5177460654Missense_MutationNAS274W0.26
COADchr5177466957Missense_MutationNAR221C0.27
COADchr5177466989Missense_MutationNAR210Q0.39
COADchr51774573963'UTRrs7536647910.39
COADchr5177459637Intronnovel0.32
COADchr5177459164Missense_Mutationrs753006714R354W0.24
COADchr5177466955Silentrs372439938R221R0.34
COADchr5177458433Silentrs748601855N467N0.43
COADchr5177459158Missense_MutationNAL356M0.28
COADchr5177457474Missense_MutationNAP637A0.33
COADchr5177458554Missense_MutationnovelA427V0.15
COADchr5177458118SilentNAE572E0.17
COADchr5177472129Intronrs5678499830.33
COADchr5177458499Missense_MutationnovelE445D0.18
ESCAchr5177472387Intronnovel0.13
HNSCchr5177472142Intronnovel0.14
KIRCchr5177467264Missense_MutationNAE182D0.09
KIRCchr5177467656Intronnovel0.36
KIRCchr5177467266Frame_Shift_DelnovelE182Sfs*610.45
KIRCchr5177466973SilentNAR215R0.58
LGGchr5177466795Missense_MutationNAR250W0.38
LIHCchr5177458387Missense_MutationNAG483W0.41
LIHCchr5177472176IntronNA0.47
LIHCchr5177460552Missense_MutationNAA279T0.51
LIHCchr5177459226Missense_MutationNAI333T0.23
LIHCchr5177468870Missense_MutationNAD39V0.08
LIHCchr5177466948Missense_Mutationrs747285882R224C0.45
LIHCchr5177468870Missense_MutationNAD39V0.14
LUADchr5177468871Missense_MutationnovelD39Y0.16
LUADchr5177460644Splice_Regionrs777890271E277E0.14
LUADchr51774574073'UTRnovel0.17
LUADchr5177458478SilentNAT452T0.35
LUADchr5177458504Missense_MutationnovelT444A0.27
LUADchr5177458617Missense_MutationnovelQ406L0.17
LUADchr5177458525Nonsense_MutationNAE437*0.3
LUADchr5177467023Missense_MutationNAA199T0.17
LUADchr5177460700Missense_MutationNAD259N0.71
LUADchr5177458261Missense_Mutationrs142058925E525K0.37
LUSCchr5177457703Missense_MutationnovelE611K0.4
LUSCchr5177458393Missense_MutationnovelG481C0.48
LUSCchr5177458084Missense_MutationNAE584K0.18
LUSCchr5177466794Missense_MutationNAR250L0.51
LUSCchr5177457732Missense_MutationNAS601L0.24
LUSCchr5177468876Missense_MutationnovelG37V0.27
LUSCchr5177466794Missense_MutationnovelR250P0.74
OVchr5177472145Intronrs3694763950.48
OVchr5177460452Missense_Mutationrs140640004S312L0.03
OVchr5177458155Missense_MutationnovelP560R0.43
PAADchr5177458541SilentnovelV431V0.14
READchr5177459217Missense_Mutationrs144418852R336Q0.25
READchr5177460508Missense_MutationnovelF293L0.39
SARCchr5177460694Missense_MutationnovelR261W0.42
SARCchr5177467046Missense_MutationnovelR191Q0.46
SARCchr5177468859Missense_MutationnovelL43I0.07
SARCchr5177458488Frame_Shift_InsnovelA449Gfs*30.47
SKCMchr5177458176Missense_MutationNAS553F0.4
SKCMchr5177459131Missense_MutationNAP365S0.13
SKCMchr5177458200Missense_MutationNAD545A0.16
SKCMchr5177459200Missense_MutationNAS342G0.54
SKCMchr5177467000Silentrs760584074F206F0.22
SKCMchr5177458143Missense_MutationnovelS564L0.3
SKCMchr5177472217Intronnovel0.05
SKCMchr5177458601SilentNAP411P0.66
STADchr5177458650Missense_MutationNAQ395R0.43
STADchr5177472145Intronrs3694763950.46
STADchr5177459194Missense_Mutationrs201033708A344T0.23
STADchr5177458162Frame_Shift_DelNAQ558Rfs*230.35
STADchr5177459117Silentrs139033012P369P0.55
STADchr5177467294Missense_MutationNAM172I0.22
STADchr5177459155Missense_MutationNAD357N0.13
STADchr5177458639Missense_Mutationrs778345277G399S0.13
STADchr51774573053'UTRnovel0.17
STADchr5177467258SilentNAA184A0.38
STADchr5177472272Intronnovel0.54
UCECchr51774571873'UTRnovel0.24
UCECchr51774571163'UTRnovel0.43
UCECchr5177468201Silentrs772411637L54L0.29
UCECchr5177457689Missense_MutationnovelK615N0.4
UCECchr5177458433Silentrs748601855N467N0.48
UCECchr5177467277Missense_MutationnovelE178V0.32
UCECchr5177467000Silentrs760584074F206F0.49
UCECchr5177467583Silentrs374573989D125D0.46
UCECchr5177460530Missense_MutationnovelR286Q0.61
UCECchr5177460487Silentrs528266629V300V0.13
UCECchr5177472314Intronnovel0.12
UCECchr5177458267Missense_MutationnovelA523T0.33
UCECchr5177458136Silentrs758241367L566L0.23
UCECchr5177460473Missense_Mutationrs765629822A305V0.46
UCECchr5177467657Intronnovel0.6
UCECchr5177457448Silentrs773887286F645F0.24
UCECchr5177467482Missense_MutationnovelV159A0.41
UCECchr5177458251Missense_MutationnovelA528V0.7
UCECchr51774572553'UTRnovel0.27
UCECchr5177458396Missense_Mutationrs772758801P480S0.4
UCECchr51774572273'UTRnovel0.35
UCECchr5177458420Missense_Mutationrs151027179A472T0.37
UCECchr5177457498Missense_Mutationrs760744775D629N0.36
UCECchr5177467545Missense_MutationnovelA138V0.36
UCECchr5177459180Silentrs567476563V348V0.26
UCECchr5177460463SilentnovelC308C0.24
UCECchr5177460654Missense_MutationNAS274L0.26
UCECchr5177466957Missense_MutationNAR221C0.56
UCECchr51774569743'UTRnovel0.38
UCECchr5177468119Missense_MutationnovelL82I0.39
UCECchr5177472336Intronnovel0.36
UCECchr5177467540Missense_MutationnovelL140F0.31
UCECchr51774567473'UTRnovel0.26
UCECchr5177458423Missense_MutationNAA471T0.39
UCECchr5177472204Intronnovel0.27
UCECchr5177460654Missense_MutationNAS274L0.23
UCECchr5177467493Silentrs146876816N155N0.21
UCECchr5177459179Missense_Mutationrs763518397A349T0.5
UCECchr5177460693Missense_Mutationrs776167710R261Q0.21
UCECchr5177466947Missense_MutationnovelR224H0.21
UCECchr5177458424Silentrs374007032P470P0.46
UCECchr51774570833'UTRnovel0.5
UCECchr5177460451Silentrs745308641S312S0.17
UCECchr5177458485Missense_MutationnovelA450V0.42
UCECchr5177459179Missense_Mutationrs763518397A349T0.37
UCECchr5177457684Missense_MutationnovelP617L0.35
UCSchr5177472272Intronnovel0.13

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRCAMP0.59092.1944e-60
KIRPAMP0.11110.069756
KIRPDEL0.03820.11554
LUADAMP0.17440.24967
LUSCDEL0.59280.002071
MESODEL0.11490.20184
PRADAMP0.03250.16448
SKCMAMP0.12260.23703
THCADEL00.23456
UCECAMP0.07420.14254

Survival Analysis
CancerP-value Q-value
THYM0.009

Kaplan-Meier Survival Analysis

KIRC0.00029

Kaplan-Meier Survival Analysis

MESO0.00012

Kaplan-Meier Survival Analysis

ACC0.0025

Kaplan-Meier Survival Analysis

UCS0.013

Kaplan-Meier Survival Analysis

SKCM0.002

Kaplan-Meier Survival Analysis

BLCA0.0047

Kaplan-Meier Survival Analysis

CESC0.012

Kaplan-Meier Survival Analysis

UCEC0.0087

Kaplan-Meier Survival Analysis

LIHC0.0063

Kaplan-Meier Survival Analysis

LGG0.0038

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000113758 (Gene tree)
Gene ID
1627
Gene Symbol
DBN1
Alias
D0S117E
Full Name
drebrin 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
23,729 bases
Position
chr5:177,456,608-177,480,336
Accession
2695
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000514833DBN1-211456-ENSP00000421465124 (aa)-D6RFI1
ENST00000292385DBN1-2013072XM_011534446ENSP00000292385651 (aa)XP_011532748Q16643
ENST00000309007DBN1-2022995-ENSP00000308532649 (aa)-Q16643
ENST00000505550DBN1-208534--- (aa)--
ENST00000512501DBN1-2101878-ENSP00000423208391 (aa)-D6R9Q9
ENST00000393565DBN1-2032701XM_005265827ENSP00000377195695 (aa)XP_005265884Q16643
ENST00000472831DBN1-2062667--- (aa)--
ENST00000467054DBN1-204793--- (aa)--
ENST00000506117DBN1-209477-ENSP0000042554693 (aa)-D6RCR4
ENST00000477391DBN1-2071044-ENSP00000422854317 (aa)-D6R9W4
ENST00000471767DBN1-205428--- (aa)--
Gene Model
Click here to download ENSG00000113758's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000113758Heart Failure4.4110906E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000113758rs25457955177460105AEducational attainment (MTAG)30038396[0.01-0.016] unit increase0.013EFO_0004784
ENSG00000113758rs24503335177472545AIntelligence29942086z-score decrease6.727EFO_0004337
ENSG00000113758rs25457955177460105AEducational attainment (years of education)30038396[0.0098-0.0152] unit increase0.0125EFO_0004784
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113758's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003779actin binding12761245.NASFunction
GO:0005515protein binding12577067.20215400.21044950.23750010.23926103.23940795.25814554.25839164.28966017.IPIFunction
GO:0005522profilin binding-ISSFunction
GO:0005737cytoplasm8838578.28966017.IDAComponent
GO:0005737cytoplasm12009525.NASComponent
GO:0005856cytoskeleton24327345.IDAComponent
GO:0005921gap junction-IEAComponent
GO:0007015actin filament organization-ISSProcess
GO:0010643cell communication by chemical coupling-IEAProcess
GO:0010644cell communication by electrical coupling-IEAProcess
GO:0014069postsynaptic density-IEAComponent
GO:0015629actin cytoskeleton-ISSComponent
GO:0030425dendrite8838578.IDAComponent
GO:0030425dendrite12009525.NASComponent
GO:0030426growth cone-ISSComponent
GO:0030863cortical cytoskeleton17251419.TASComponent
GO:0031915positive regulation of synaptic plasticity-ISSProcess
GO:0032507maintenance of protein location in cell-IEAProcess
GO:0042641actomyosin12761245.NASComponent
GO:0045211postsynaptic membrane-IEAComponent
GO:0045296cadherin binding25468996.HDAFunction
GO:0048168regulation of neuronal synaptic plasticity12009525.NASProcess
GO:0050773regulation of dendrite development12009525.NASProcess
GO:0051220cytoplasmic sequestering of protein28966017.IDAProcess
GO:0061003positive regulation of dendritic spine morphogenesis-ISSProcess
GO:0061351neural precursor cell proliferation-IEAProcess
GO:0098978glutamatergic synapse-IEAComponent
GO:0099524postsynaptic cytosol-IEAComponent
GO:1902685positive regulation of receptor localization to synapse-ISSProcess
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