EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28865028	Drebrin at Junctional Plaques.	Adv Exp Med Biol	2017	Ludwig-Peitsch WK	doi: 10.1007/978-4-431-56550-5_18.
24346822	Expression of drebrin, an actin binding protein, in basal cell carcinoma, trichoblastoma and trichoepithelioma.	Histol Histopathol	2014 Jun	Mizutani Y	doi: 10.14670/HH-29.757
28865033	The Role of Drebrin in Cancer Cell Invasion.	Adv Exp Med Biol	2017	Dart AE	doi: 10.1007/978-4-431-56550-5_23.
28865011	General Introduction to Drebrin.	Adv Exp Med Biol	2017	Shirao T	doi: 10.1007/978-4-431-56550-5_1.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr5	177458467	Missense_Mutation	rs775591763	D456A	0.2
ACC	chr5	177467040	Missense_Mutation	novel	E193A	0.08
BLCA	chr5	177458267	Missense_Mutation	novel	A523T	0.17
BLCA	chr5	177458083	Missense_Mutation	NA	E584G	0.21
BLCA	chr5	177457748	Frame_Shift_Del	novel	*S594Vfs53**	0.08
BLCA	chr5	177460462	Missense_Mutation	novel	D309Y	0.39
BLCA	chr5	177460531	Silent	novel	R286R	0.46
BRCA	chr5	177458520	Silent	novel	P438P	0.39
BRCA	chr5	177458420	Missense_Mutation	rs151027179	A472T	0.25
BRCA	chr5	177458609	Missense_Mutation	NA	A409T	0.43
BRCA	chr5	177466963	Missense_Mutation	novel	E219Q	0.26
BRCA	chr5	177468199	Missense_Mutation	rs558662294	S55L	0.12
BRCA	chr5	177457397	3'UTR	rs374930581		0.31
BRCA	chr5	177458057	Splice_Site	NA	X592_splice	0.64
BRCA	chr5	177458084	Missense_Mutation	NA	E584K	0.5
BRCA	chr5	177472138	Intron	novel		0.18
BRCA	chr5	177472139	Intron	novel		0.18
BRCA	chr5	177467045	Silent	novel	R191R	0.08
CESC	chr5	177459202	Missense_Mutation	NA	S341F	0.32
CESC	chr5	177457661	Missense_Mutation	novel	P625S	0.14
CESC	chr5	177457463	Missense_Mutation	novel	E640D	0.06
CESC	chr5	177456773	3'UTR	novel		0.32
CESC	chr5	177458420	Missense_Mutation	rs151027179	A472T	0.19
CESC	chr5	177460487	Silent	rs528266629	V300V	0.07
CESC	chr5	177467311	Missense_Mutation	NA	D167H	0.2
CESC	chr5	177458388	Silent	rs370979617	N482N	0.37
CESC	chr5	177460654	Missense_Mutation	NA	S274W	0.26
COAD	chr5	177466957	Missense_Mutation	NA	R221C	0.27
COAD	chr5	177466989	Missense_Mutation	NA	R210Q	0.39
COAD	chr5	177457396	3'UTR	rs753664791		0.39
COAD	chr5	177459637	Intron	novel		0.32
COAD	chr5	177459164	Missense_Mutation	rs753006714	R354W	0.24
COAD	chr5	177466955	Silent	rs372439938	R221R	0.34
COAD	chr5	177458433	Silent	rs748601855	N467N	0.43
COAD	chr5	177459158	Missense_Mutation	NA	L356M	0.28
COAD	chr5	177457474	Missense_Mutation	NA	P637A	0.33
COAD	chr5	177458554	Missense_Mutation	novel	A427V	0.15
COAD	chr5	177458118	Silent	NA	E572E	0.17
COAD	chr5	177472129	Intron	rs567849983		0.33
COAD	chr5	177458499	Missense_Mutation	novel	E445D	0.18
ESCA	chr5	177472387	Intron	novel		0.13
HNSC	chr5	177472142	Intron	novel		0.14
KIRC	chr5	177467264	Missense_Mutation	NA	E182D	0.09
KIRC	chr5	177467656	Intron	novel		0.36
KIRC	chr5	177467266	Frame_Shift_Del	novel	*E182Sfs61**	0.45
KIRC	chr5	177466973	Silent	NA	R215R	0.58
LGG	chr5	177466795	Missense_Mutation	NA	R250W	0.38
LIHC	chr5	177458387	Missense_Mutation	NA	G483W	0.41
LIHC	chr5	177472176	Intron	NA		0.47
LIHC	chr5	177460552	Missense_Mutation	NA	A279T	0.51
LIHC	chr5	177459226	Missense_Mutation	NA	I333T	0.23
LIHC	chr5	177468870	Missense_Mutation	NA	D39V	0.08
LIHC	chr5	177466948	Missense_Mutation	rs747285882	R224C	0.45
LIHC	chr5	177468870	Missense_Mutation	NA	D39V	0.14
LUAD	chr5	177468871	Missense_Mutation	novel	D39Y	0.16
LUAD	chr5	177460644	Splice_Region	rs777890271	E277E	0.14
LUAD	chr5	177457407	3'UTR	novel		0.17
LUAD	chr5	177458478	Silent	NA	T452T	0.35
LUAD	chr5	177458504	Missense_Mutation	novel	T444A	0.27
LUAD	chr5	177458617	Missense_Mutation	novel	Q406L	0.17
LUAD	chr5	177458525	Nonsense_Mutation	NA	E437*	0.3
LUAD	chr5	177467023	Missense_Mutation	NA	A199T	0.17
LUAD	chr5	177460700	Missense_Mutation	NA	D259N	0.71
LUAD	chr5	177458261	Missense_Mutation	rs142058925	E525K	0.37
LUSC	chr5	177457703	Missense_Mutation	novel	E611K	0.4
LUSC	chr5	177458393	Missense_Mutation	novel	G481C	0.48
LUSC	chr5	177458084	Missense_Mutation	NA	E584K	0.18
LUSC	chr5	177466794	Missense_Mutation	NA	R250L	0.51
LUSC	chr5	177457732	Missense_Mutation	NA	S601L	0.24
LUSC	chr5	177468876	Missense_Mutation	novel	G37V	0.27
LUSC	chr5	177466794	Missense_Mutation	novel	R250P	0.74
OV	chr5	177472145	Intron	rs369476395		0.48
OV	chr5	177460452	Missense_Mutation	rs140640004	S312L	0.03
OV	chr5	177458155	Missense_Mutation	novel	P560R	0.43
PAAD	chr5	177458541	Silent	novel	V431V	0.14
READ	chr5	177459217	Missense_Mutation	rs144418852	R336Q	0.25
READ	chr5	177460508	Missense_Mutation	novel	F293L	0.39
SARC	chr5	177460694	Missense_Mutation	novel	R261W	0.42
SARC	chr5	177467046	Missense_Mutation	novel	R191Q	0.46
SARC	chr5	177468859	Missense_Mutation	novel	L43I	0.07
SARC	chr5	177458488	Frame_Shift_Ins	novel	*A449Gfs3**	0.47
SKCM	chr5	177458176	Missense_Mutation	NA	S553F	0.4
SKCM	chr5	177459131	Missense_Mutation	NA	P365S	0.13
SKCM	chr5	177458200	Missense_Mutation	NA	D545A	0.16
SKCM	chr5	177459200	Missense_Mutation	NA	S342G	0.54
SKCM	chr5	177467000	Silent	rs760584074	F206F	0.22
SKCM	chr5	177458143	Missense_Mutation	novel	S564L	0.3
SKCM	chr5	177472217	Intron	novel		0.05
SKCM	chr5	177458601	Silent	NA	P411P	0.66
STAD	chr5	177458650	Missense_Mutation	NA	Q395R	0.43
STAD	chr5	177472145	Intron	rs369476395		0.46
STAD	chr5	177459194	Missense_Mutation	rs201033708	A344T	0.23
STAD	chr5	177458162	Frame_Shift_Del	NA	*Q558Rfs23**	0.35
STAD	chr5	177459117	Silent	rs139033012	P369P	0.55
STAD	chr5	177467294	Missense_Mutation	NA	M172I	0.22
STAD	chr5	177459155	Missense_Mutation	NA	D357N	0.13
STAD	chr5	177458639	Missense_Mutation	rs778345277	G399S	0.13
STAD	chr5	177457305	3'UTR	novel		0.17
STAD	chr5	177467258	Silent	NA	A184A	0.38
STAD	chr5	177472272	Intron	novel		0.54
UCEC	chr5	177457187	3'UTR	novel		0.24
UCEC	chr5	177457116	3'UTR	novel		0.43
UCEC	chr5	177468201	Silent	rs772411637	L54L	0.29
UCEC	chr5	177457689	Missense_Mutation	novel	K615N	0.4
UCEC	chr5	177458433	Silent	rs748601855	N467N	0.48
UCEC	chr5	177467277	Missense_Mutation	novel	E178V	0.32
UCEC	chr5	177467000	Silent	rs760584074	F206F	0.49
UCEC	chr5	177467583	Silent	rs374573989	D125D	0.46
UCEC	chr5	177460530	Missense_Mutation	novel	R286Q	0.61
UCEC	chr5	177460487	Silent	rs528266629	V300V	0.13
UCEC	chr5	177472314	Intron	novel		0.12
UCEC	chr5	177458267	Missense_Mutation	novel	A523T	0.33
UCEC	chr5	177458136	Silent	rs758241367	L566L	0.23
UCEC	chr5	177460473	Missense_Mutation	rs765629822	A305V	0.46
UCEC	chr5	177467657	Intron	novel		0.6
UCEC	chr5	177457448	Silent	rs773887286	F645F	0.24
UCEC	chr5	177467482	Missense_Mutation	novel	V159A	0.41
UCEC	chr5	177458251	Missense_Mutation	novel	A528V	0.7
UCEC	chr5	177457255	3'UTR	novel		0.27
UCEC	chr5	177458396	Missense_Mutation	rs772758801	P480S	0.4
UCEC	chr5	177457227	3'UTR	novel		0.35
UCEC	chr5	177458420	Missense_Mutation	rs151027179	A472T	0.37
UCEC	chr5	177457498	Missense_Mutation	rs760744775	D629N	0.36
UCEC	chr5	177467545	Missense_Mutation	novel	A138V	0.36
UCEC	chr5	177459180	Silent	rs567476563	V348V	0.26
UCEC	chr5	177460463	Silent	novel	C308C	0.24
UCEC	chr5	177460654	Missense_Mutation	NA	S274L	0.26
UCEC	chr5	177466957	Missense_Mutation	NA	R221C	0.56
UCEC	chr5	177456974	3'UTR	novel		0.38
UCEC	chr5	177468119	Missense_Mutation	novel	L82I	0.39
UCEC	chr5	177472336	Intron	novel		0.36
UCEC	chr5	177467540	Missense_Mutation	novel	L140F	0.31
UCEC	chr5	177456747	3'UTR	novel		0.26
UCEC	chr5	177458423	Missense_Mutation	NA	A471T	0.39
UCEC	chr5	177472204	Intron	novel		0.27
UCEC	chr5	177460654	Missense_Mutation	NA	S274L	0.23
UCEC	chr5	177467493	Silent	rs146876816	N155N	0.21
UCEC	chr5	177459179	Missense_Mutation	rs763518397	A349T	0.5
UCEC	chr5	177460693	Missense_Mutation	rs776167710	R261Q	0.21
UCEC	chr5	177466947	Missense_Mutation	novel	R224H	0.21
UCEC	chr5	177458424	Silent	rs374007032	P470P	0.46
UCEC	chr5	177457083	3'UTR	novel		0.5
UCEC	chr5	177460451	Silent	rs745308641	S312S	0.17
UCEC	chr5	177458485	Missense_Mutation	novel	A450V	0.42
UCEC	chr5	177459179	Missense_Mutation	rs763518397	A349T	0.37
UCEC	chr5	177457684	Missense_Mutation	novel	P617L	0.35
UCS	chr5	177472272	Intron	novel		0.13

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.5909	2.1944e-60
KIRP	AMP	0.1111	0.069756
KIRP	DEL	0.0382	0.11554
LUAD	AMP	0.1744	0.24967
LUSC	DEL	0.5928	0.002071
MESO	DEL	0.1149	0.20184
PRAD	AMP	0.0325	0.16448
SKCM	AMP	0.1226	0.23703
THCA	DEL	0	0.23456
UCEC	AMP	0.0742	0.14254

Survival Analysis

Cancer	P-value	Q-value
THYM	0.009	Kaplan-Meier Survival Analysis
KIRC	0.00029	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
ACC	0.0025	Kaplan-Meier Survival Analysis
UCS	0.013	Kaplan-Meier Survival Analysis
SKCM	0.002	Kaplan-Meier Survival Analysis
BLCA	0.0047	Kaplan-Meier Survival Analysis
CESC	0.012	Kaplan-Meier Survival Analysis
UCEC	0.0087	Kaplan-Meier Survival Analysis
LIHC	0.0063	Kaplan-Meier Survival Analysis
LGG	0.0038	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000113758 (Gene tree)
Gene ID: 1627
Gene Symbol: DBN1
Alias: D0S117E
Full Name: drebrin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 23,729 bases
Position: chr5:177,456,608-177,480,336
Accession: 2695
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000514833	DBN1-211	456	-	ENSP00000421465	124 (aa)	-	D6RFI1
ENST00000292385	DBN1-201	3072	XM_011534446	ENSP00000292385	651 (aa)	XP_011532748	Q16643
ENST00000309007	DBN1-202	2995	-	ENSP00000308532	649 (aa)	-	Q16643
ENST00000505550	DBN1-208	534	-	-	- (aa)	-	-
ENST00000512501	DBN1-210	1878	-	ENSP00000423208	391 (aa)	-	D6R9Q9
ENST00000393565	DBN1-203	2701	XM_005265827	ENSP00000377195	695 (aa)	XP_005265884	Q16643
ENST00000472831	DBN1-206	2667	-	-	- (aa)	-	-
ENST00000467054	DBN1-204	793	-	-	- (aa)	-	-
ENST00000506117	DBN1-209	477	-	ENSP00000425546	93 (aa)	-	D6RCR4
ENST00000477391	DBN1-207	1044	-	ENSP00000422854	317 (aa)	-	D6R9W4
ENST00000471767	DBN1-205	428	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000113758's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000113758	Heart Failure	4.4110906E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000113758	rs2545795	5	177460105	A	Educational attainment (MTAG)	30038396	[0.01-0.016] unit increase	0.013	EFO_0004784
ENSG00000113758	rs2450333	5	177472545	A	Intelligence	29942086	z-score decrease	6.727	EFO_0004337
ENSG00000113758	rs2545795	5	177460105	A	Educational attainment (years of education)	30038396	[0.0098-0.0152] unit increase	0.0125	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113758's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	12761245.	NAS	Function
GO:0005515	protein binding	12577067.20215400.21044950.23750010.23926103.23940795.25814554.25839164.28966017.	IPI	Function
GO:0005522	profilin binding	-	ISS	Function
GO:0005737	cytoplasm	8838578.28966017.	IDA	Component
GO:0005737	cytoplasm	12009525.	NAS	Component
GO:0005856	cytoskeleton	24327345.	IDA	Component
GO:0005921	gap junction	-	IEA	Component
GO:0007015	actin filament organization	-	ISS	Process
GO:0010643	cell communication by chemical coupling	-	IEA	Process
GO:0010644	cell communication by electrical coupling	-	IEA	Process
GO:0014069	postsynaptic density	-	IEA	Component
GO:0015629	actin cytoskeleton	-	ISS	Component
GO:0030425	dendrite	8838578.	IDA	Component
GO:0030425	dendrite	12009525.	NAS	Component
GO:0030426	growth cone	-	ISS	Component
GO:0030863	cortical cytoskeleton	17251419.	TAS	Component
GO:0031915	positive regulation of synaptic plasticity	-	ISS	Process
GO:0032507	maintenance of protein location in cell	-	IEA	Process
GO:0042641	actomyosin	12761245.	NAS	Component
GO:0045211	postsynaptic membrane	-	IEA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0048168	regulation of neuronal synaptic plasticity	12009525.	NAS	Process
GO:0050773	regulation of dendrite development	12009525.	NAS	Process
GO:0051220	cytoplasmic sequestering of protein	28966017.	IDA	Process
GO:0061003	positive regulation of dendritic spine morphogenesis	-	ISS	Process
GO:0061351	neural precursor cell proliferation	-	IEA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099524	postsynaptic cytosol	-	IEA	Component
GO:1902685	positive regulation of receptor localization to synapse	-	ISS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.