Cancer | Chr | Position | Mutation Type | dbSNP | Protein-change | Allele Freq | RBD |
---|---|---|---|---|---|---|---|
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
ESCA | |||||||
ESCA | |||||||
GBM | |||||||
GBM | |||||||
GBM | |||||||
HNSC | |||||||
HNSC | |||||||
HNSC | |||||||
KIRC | |||||||
KIRC | |||||||
KIRC | |||||||
KIRC | |||||||
KIRP | |||||||
KIRP | |||||||
LAML | |||||||
LGG | |||||||
LGG | |||||||
LUAD | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
OV | |||||||
OV | |||||||
OV | |||||||
OV | |||||||
OV | |||||||
PAAD | |||||||
PRAD | |||||||
PRAD | |||||||
READ | |||||||
READ | |||||||
READ | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCS |
Cancer | Type | Freq | Q-value |
---|---|---|---|
BRCA | |||
CHOL | |||
DLBC | |||
GBM | |||
KIRP | |||
LGG | |||
LUAD | |||
PAAD | |||
SARC | |||
SKCM | |||
TGCT | |||
TGCT | |||
THCA | |||
THYM | |||
UCS | |||
UVM |
Cancer | P-value | Q-value |
---|---|---|
THYM | ||
SKCM | ||
LUSC | ||
BRCA | ||
ESCA | ||
TGCT | ||
PAAD | ||
PCPG | ||
READ | ||
LAML | ||
UCEC | ||
LIHC | ||
LGG | ||
CHOL | ||
UVM |
Transcript ID | Name | Length | RefSeq ID | Protein ID | Length | RefSeq ID | UniportKB ID |
---|---|---|---|---|---|---|---|
ENST00000266027 | GNAI2-201 | 2169 | - | ENSP00000266027 | 303 (aa) | - | P04899 |
ENST00000446079 | GNAI2-206 | 2086 | - | ENSP00000406065 | 146 (aa) | - | F8WBG4 |
ENST00000492383 | GNAI2-212 | 989 | - | - | - (aa) | - | - |
ENST00000468422 | GNAI2-208 | 531 | - | - | - (aa) | - | - |
ENST00000490122 | GNAI2-210 | 2445 | - | - | - (aa) | - | - |
ENST00000480090 | GNAI2-209 | 284 | - | - | - (aa) | - | - |
ENST00000313601 | GNAI2-202 | 2464 | - | ENSP00000312999 | 355 (aa) | - | P04899 |
ENST00000491100 | GNAI2-211 | 3886 | - | - | - (aa) | - | - |
ENST00000440628 | GNAI2-204 | 1663 | - | ENSP00000395736 | 303 (aa) | - | P04899 |
ENST00000441156 | GNAI2-205 | 2168 | - | ENSP00000394321 | 142 (aa) | - | F8WE78 |
ENST00000451956 | GNAI2-207 | 1486 | - | ENSP00000406369 | 318 (aa) | - | P04899 |
ENST00000422163 | GNAI2-203 | 2407 | - | ENSP00000406871 | 339 (aa) | - | P04899 |
Pathway ID | Pathway Name | Source |
---|---|---|
hsa04015 | Rap1 signaling pathway | KEGG |
hsa04022 | cGMP-PKG signaling pathway | KEGG |
hsa04024 | cAMP signaling pathway | KEGG |
hsa04062 | Chemokine signaling pathway | KEGG |
hsa04071 | Sphingolipid signaling pathway | KEGG |
hsa04261 | Adrenergic signaling in cardiomyocytes | KEGG |
hsa04360 | Axon guidance | KEGG |
hsa04371 | Apelin signaling pathway | KEGG |
hsa04540 | Gap junction | KEGG |
hsa04611 | Platelet activation | KEGG |
hsa04670 | Leukocyte transendothelial migration | KEGG |
hsa04713 | Circadian entrainment | KEGG |
hsa04723 | Retrograde endocannabinoid signaling | KEGG |
hsa04724 | Glutamatergic synapse | KEGG |
hsa04725 | Cholinergic synapse | KEGG |
hsa04726 | Serotonergic synapse | KEGG |
hsa04727 | GABAergic synapse | KEGG |
hsa04728 | Dopaminergic synapse | KEGG |
hsa04730 | Long-term depression | KEGG |
hsa04914 | Progesterone-mediated oocyte maturation | KEGG |
hsa04915 | Estrogen signaling pathway | KEGG |
hsa04916 | Melanogenesis | KEGG |
hsa04921 | Oxytocin signaling pathway | KEGG |
hsa04923 | Regulation of lipolysis in adipocytes | KEGG |
hsa04924 | Renin secretion | KEGG |
hsa04926 | Relaxin signaling pathway | KEGG |
hsa04928 | Parathyroid hormone synthesis, secretion and action | KEGG |
hsa04934 | Cushing syndrome | KEGG |
hsa04971 | Gastric acid secretion | KEGG |
hsa05012 | Parkinson disease | KEGG |
hsa05030 | Cocaine addiction | KEGG |
hsa05032 | Morphine addiction | KEGG |
hsa05034 | Alcoholism | KEGG |
hsa05133 | Pertussis | KEGG |
hsa05142 | Chagas disease (American trypanosomiasis) | KEGG |
hsa05145 | Toxoplasmosis | KEGG |
hsa05163 | Human cytomegalovirus infection | KEGG |
hsa05170 | Human immunodeficiency virus 1 infection | KEGG |
hsa05200 | Pathways in cancer | KEGG |
ensgID | SNP | Chromosome | Position | SNP-risk | Trait | PubmedID | 95% CI | Or or BEAT | EFO ID |
---|---|---|---|---|---|---|---|---|---|
ENSG00000114353 | rs2298952 | 3 | 50249521 | A | Cognitive performance | 30038396 | [0.019-0.038] unit decrease | 0.0283 | EFO_0008354 |
ENSG00000114353 | rs2097247 | 3 | 50253470 | T | Feeling tense | 29500382 | z score increase | 5.94 | EFO_0009596 |
ENSG00000114353 | rs181394846 | 3 | 50255960 | C | Macrophage inflammatory protein 1b levels | 27989323 | [0.14-0.27] SD units decrease | 0.2059 | EFO_0008219 |
ENSG00000114353 | rs62260798 | 3 | 50236846 | T | Morning person | 30696823 | 1.0527 | EFO_0008328 |
Ensembl ID | Gene Symbol | Coverage | Identiy | Ortholog | Gene Symbol | Coverage | Identiy | Species |
---|---|---|---|---|---|---|---|---|
ENSG00000114353 | GNAI2 | 100 | 98.310 | ENSMUSG00000032562 | Gnai2 | 100 | 100.000 | Mus_musculus |
Go ID | Go_term | PubmedID | Evidence | Category |
---|---|---|---|---|
GO:0001664 | G protein-coupled receptor binding | 21873635. | IBA | Function |
GO:0001973 | adenosine receptor signaling pathway | 21873635. | IBA | Process |
GO:0003924 | GTPase activity | 21873635. | IBA | Function |
GO:0005515 | protein binding | 16189514.16782902.18599439.23773523.25241761.25416956. | IPI | Function |
GO:0005525 | GTP binding | - | IEA | Function |
GO:0005654 | nucleoplasm | - | IDA | Component |
GO:0005737 | cytoplasm | 17635935. | IDA | Component |
GO:0005813 | centrosome | 17635935. | IDA | Component |
GO:0005829 | cytosol | - | IDA | Component |
GO:0005834 | heterotrimeric G-protein complex | 21873635. | IBA | Component |
GO:0005886 | plasma membrane | 17635935. | IDA | Component |
GO:0005886 | plasma membrane | - | TAS | Component |
GO:0006457 | protein folding | - | TAS | Process |
GO:0007049 | cell cycle | - | IEA | Process |
GO:0007165 | signal transduction | 7961880.9637720. | TAS | Process |
GO:0007186 | G protein-coupled receptor signaling pathway | - | TAS | Process |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 21873635. | IBA | Process |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | - | IEA | Process |
GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 21873635. | IBA | Process |
GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | - | TAS | Process |
GO:0007194 | negative regulation of adenylate cyclase activity | 9637720. | TAS | Process |
GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | - | IEA | Process |
GO:0007214 | gamma-aminobutyric acid signaling pathway | 21873635. | IBA | Process |
GO:0007584 | response to nutrient | 8587610. | TAS | Process |
GO:0008283 | cell proliferation | - | IEA | Process |
GO:0008284 | positive regulation of cell proliferation | 21079996. | IMP | Process |
GO:0016020 | membrane | 19946888. | HDA | Component |
GO:0030335 | positive regulation of cell migration | - | IEA | Process |
GO:0030425 | dendrite | - | IEA | Component |
GO:0030496 | midbody | 17635935. | IDA | Component |
GO:0031683 | G-protein beta/gamma-subunit complex binding | 21873635. | IBA | Function |
GO:0032930 | positive regulation of superoxide anion generation | - | IEA | Process |
GO:0033864 | positive regulation of NAD(P)H oxidase activity | - | IEA | Process |
GO:0035810 | positive regulation of urine volume | - | IEA | Process |
GO:0035815 | positive regulation of renal sodium excretion | - | IEA | Process |
GO:0044297 | cell body | - | IEA | Component |
GO:0045121 | membrane raft | - | IEA | Component |
GO:0045955 | negative regulation of calcium ion-dependent exocytosis | - | IEA | Process |
GO:0046628 | positive regulation of insulin receptor signaling pathway | - | IEA | Process |
GO:0046872 | metal ion binding | - | IEA | Function |
GO:0050805 | negative regulation of synaptic transmission | - | IEA | Process |
GO:0051301 | cell division | 17635935. | IMP | Process |
GO:0051924 | regulation of calcium ion transport | - | IEA | Process |
GO:0070062 | extracellular exosome | 12519789.19056867.19199708.20458337. | HDA | Component |
GO:0070374 | positive regulation of ERK1 and ERK2 cascade | - | IEA | Process |
GO:0140199 | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process | - | IEA | Process |
GO:1903561 | extracellular vesicle | 24769233. | HDA | Component |
GO:1903614 | negative regulation of protein tyrosine phosphatase activity | - | IEA | Process |
GO:1904707 | positive regulation of vascular smooth muscle cell proliferation | - | IEA | Process |
GO:2000179 | positive regulation of neural precursor cell proliferation | - | IEA | Process |
GO:2001234 | negative regulation of apoptotic signaling pathway | - | IEA | Process |