EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25652905	Expression and role of V1A subunit of V-ATPases in gastric cancer cells.	Int J Clin Oncol	2015 Aug	Liu P	doi: 10.1007/s10147-015-0782-y
28592880	Expression and Transcriptional Regulation of Human ATP6V1A Gene in Gastric Cancers.	Sci Rep	2017 Jun 7	Wang P	doi: 10.1038/s41598-017-03021-3.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr3	113809411	Missense_Mutation	rs140346248	R613H	0.04
BLCA	chr3	113781160	Missense_Mutation	NA	Q65E	0.24
BLCA	chr3	113784275	Missense_Mutation	rs760842074	V88A	0.18
BLCA	chr3	113789829	Missense_Mutation	NA	S326C	0.1
BLCA	chr3	113809400	Silent	NA	Q609Q	0.11
BLCA	chr3	113805516	Missense_Mutation	novel	M584I	0.52
BLCA	chr3	113805502	Missense_Mutation	novel	K580Q	0.61
BLCA	chr3	113786362	Missense_Mutation	NA	R232T	0.49
BLCA	chr3	113784412	Missense_Mutation	rs111894180	D134N	0.16
BLCA	chr3	113786346	Missense_Mutation	novel	L227V	0.12
BLCA	chr3	113781124	Missense_Mutation	NA	E53Q	0.5
BLCA	chr3	113805444	Silent	rs765616985	Q560Q	0.22
BLCA	chr3	113794959	Missense_Mutation	novel	R359T	0.19
BLCA	chr3	113805522	Missense_Mutation	novel	F586L	0.39
BRCA	chr3	113798258	Missense_Mutation	NA	D436H	0.12
BRCA	chr3	113788802	Missense_Mutation	NA	S269T	0.14
BRCA	chr3	113784272	Missense_Mutation	NA	S87F	0.32
BRCA	chr3	113811980	3'UTR	novel		0.24
BRCA	chr3	113781071	Missense_Mutation	rs367827756	A35V	0.07
BRCA	chr3	113805475	Missense_Mutation	NA	R571C	0.14
CESC	chr3	113811278	3'UTR	novel		0.32
CESC	chr3	113809422	Missense_Mutation	novel	D617N	0.18
CESC	chr3	113794932	Missense_Mutation	NA	S350C	0.23
CESC	chr3	113805472	Missense_Mutation	novel	I570V	0.41
CESC	chr3	113788770	Silent	NA	V258V	0.3
CHOL	chr3	113809571	3'UTR	novel		0.48
COAD	chr3	113798446	Splice_Region	NA	K498K	0.21
COAD	chr3	113788856	Missense_Mutation	novel	V287A	0.13
COAD	chr3	113805396	Missense_Mutation	novel	M544I	0.28
COAD	chr3	113809571	3'UTR	novel		0.37
COAD	chr3	113794895	Missense_Mutation	NA	R338C	0.36
COAD	chr3	113784781	Missense_Mutation	NA	R171Q	0.24
COAD	chr3	113809422	Missense_Mutation	NA	D617Y	0.1
COAD	chr3	113786315	Silent	novel	P216P	0.33
GBM	chr3	113784708	Missense_Mutation	NA	I147V	0.04
GBM	chr3	113788781	Missense_Mutation	novel	S262Y	0.5
GBM	chr3	113809371	Missense_Mutation	rs758392307	D600N	0.21
GBM	chr3	113784410	Nonsense_Mutation	novel	W133*	0.08
GBM	chr3	113794895	Missense_Mutation	NA	R338C	0.38
HNSC	chr3	113788793	Missense_Mutation	novel	Y266F	0.31
KIRC	chr3	113809407	Frame_Shift_Del	novel	*F612Sfs62**	0.27
KIRC	chr3	113781117	Missense_Mutation	NA	L50F	0.14
KIRP	chr3	113784748	Missense_Mutation	rs760446373	S160W	0.35
KIRP	chr3	113786372	Silent	novel	D235D	0.46
LGG	chr3	113795920	Missense_Mutation	novel	A424V	0.32
LGG	chr3	113798290	Silent	novel	P446P	0.09
LIHC	chr3	113805469	Missense_Mutation	NA	I569V	0.42
LIHC	chr3	113795097	In_Frame_Del	novel	P375_Y377del	0.17
LUAD	chr3	113805525	Missense_Mutation	novel	K587N	0.17
LUAD	chr3	113805526	Splice_Site	novel	X587_splice	0.16
LUAD	chr3	113786357	Silent	novel	G230G	0.3
LUAD	chr3	113781094	Missense_Mutation	novel	V43L	0.54
LUAD	chr3	113794904	Missense_Mutation	novel	G341C	0.23
LUAD	chr3	113809400	Missense_Mutation	NA	Q609H	0.07
LUAD	chr3	113786333	Silent	NA	P222P	0.17
LUAD	chr3	113798441	Nonsense_Mutation	NA	G497*	0.17
LUAD	chr3	113794955	Missense_Mutation	NA	L358I	0.13
LUSC	chr3	113788821	Silent	novel	V275V	0.06
LUSC	chr3	113795173	Nonsense_Mutation	novel	E399*	0.2
LUSC	chr3	113795909	Silent	NA	P420P	0.63
LUSC	chr3	113795910	Missense_Mutation	NA	V421I	0.63
LUSC	chr3	113798277	Missense_Mutation	NA	R442H	0.17
LUSC	chr3	113794923	Missense_Mutation	novel	M347T	0.05
LUSC	chr3	113805462	Silent	NA	T566T	0.28
LUSC	chr3	113803606	Missense_Mutation	novel	K506N	0.08
LUSC	chr3	113798243	Missense_Mutation	novel	V431L	0.44
LUSC	chr3	113809427	Nonstop_Mutation	NA	618Yext3	0.1
LUSC	chr3	113805372	Missense_Mutation	NA	K536N	0.18
LUSC	chr3	113778818	Missense_Mutation	rs768359551	H22R	0.08
LUSC	chr3	113805368	Missense_Mutation	rs758773602	Y535C	0.35
LUSC	chr3	113788732	Missense_Mutation	novel	T246A	0.38
LUSC	chr3	113784717	Missense_Mutation	novel	G150R	0.2
LUSC	chr3	113781098	Missense_Mutation	novel	R44T	0.13
LUSC	chr3	113778741	Splice_Region	novel		0.25
LUSC	chr3	113803616	Missense_Mutation	novel	E510Q	0.15
LUSC	chr3	113784333	Silent	NA	S107S	0.32
MESO	chr3	113809410	Missense_Mutation	novel	R613C	0.68
OV	chr3	113784422	Missense_Mutation	novel	P137R	0.11
OV	chr3	113778783	Silent	NA	L10L	0.14
OV	chr3	113786276	Missense_Mutation	novel	F203L	0.06
OV	chr3	113789808	Missense_Mutation	novel	P319L	0.6
OV	chr3	113798434	Silent	NA	Q494Q	0.28
PRAD	chr3	113788829	Missense_Mutation	NA	G278V	0.37
PRAD	chr3	113795940	Splice_Site	novel	X430_splice	0.29
READ	chr3	113778804	Silent	novel	T17T	0.07
READ	chr3	113798368	Silent	rs753550267	F472F	0.41
READ	chr3	113809563	3'UTR	novel		0.48
SARC	chr3	113811343	3'UTR	novel		0.22
SKCM	chr3	113809473	3'UTR	novel		0.5
SKCM	chr3	113803668	Missense_Mutation	novel	P527L	0.3
SKCM	chr3	113784253	Missense_Mutation	novel	R81C	0.43
SKCM	chr3	113809409	Silent	NA	F612F	0.31
SKCM	chr3	113786324	Silent	rs200823060	E219E	0.33
SKCM	chr3	113809471	3'UTR	novel		0.32
STAD	chr3	113795105	Missense_Mutation	novel	A376V	0.18
STAD	chr3	113778752	5'UTR	novel		0.16
STAD	chr3	113778784	Missense_Mutation	rs746407800	D11N	0.4
STAD	chr3	113784716	Silent	rs767161754	G149G	0.38
STAD	chr3	113789830	Frame_Shift_Del	novel	*Y328Lfs18**	0.26
STAD	chr3	113784373	Nonsense_Mutation	NA	G121*	0.15
STAD	chr3	113784227	Missense_Mutation	NA	G72D	0.18
THCA	chr3	113798419	Frame_Shift_Ins	novel	*A490Ifs22**	0.09
THCA	chr3	113798420	Missense_Mutation	novel	A490T	0.02
THYM	chr3	113778795	Silent	novel	K14K	0.3
UCEC	chr3	113809599	3'UTR	novel		0.46
UCEC	chr3	113798368	Silent	rs753550267	F472F	0.49
UCEC	chr3	113780771	Intron	novel		0.35
UCEC	chr3	113784781	Missense_Mutation	NA	R171Q	0.29
UCEC	chr3	113805384	Missense_Mutation	novel	M540I	0.17
UCEC	chr3	113809543	3'UTR	novel		0.21
UCEC	chr3	113781058	Missense_Mutation	novel	A31S	0.37
UCEC	chr3	113811374	3'UTR	novel		0.24
UCEC	chr3	113811940	3'UTR	novel		0.17
UCEC	chr3	113784254	Missense_Mutation	novel	R81H	0.3
UCEC	chr3	113798417	Missense_Mutation	NA	L489M	0.12
UCEC	chr3	113795909	Silent	rs377421207	P420P	0.12
UCEC	chr3	113784299	Missense_Mutation	NA	G96E	0.13
UCEC	chr3	113786360	Missense_Mutation	novel	Q231H	0.17
UCEC	chr3	113798374	Silent	novel	P474P	0.15
UCEC	chr3	113798316	Missense_Mutation	NA	S455N	0.38
UCEC	chr3	113811602	3'UTR	novel		0.32
UCEC	chr3	113784382	Missense_Mutation	rs749209409	V124M	0.35
UCEC	chr3	113795141	Missense_Mutation	novel	R388Q	0.31
UCEC	chr3	113812038	3'UTR	novel		0.55
UCEC	chr3	113795877	Missense_Mutation	novel	V410I	0.27
UCEC	chr3	113798373	Missense_Mutation	novel	P474H	0.4
UCEC	chr3	113809579	3'UTR	novel		0.33
UCEC	chr3	113809580	3'UTR	novel		0.33
UCEC	chr3	113788767	Silent	NA	T257T	0.32
UCEC	chr3	113809452	3'UTR	novel		0.23
UCEC	chr3	113809571	3'UTR	novel		0.3
UCEC	chr3	113809570	3'UTR	novel		0.17
UCEC	chr3	113811689	3'UTR	novel		0.4
UCEC	chr3	113809361	Missense_Mutation	novel	K596N	0.39
UCEC	chr3	113811941	3'UTR	rs16861351		0.29
UCEC	chr3	113778781	Missense_Mutation	novel	L10I	0.41
UCEC	chr3	113781112	Missense_Mutation	rs778431937	E49K	0.19
UCEC	chr3	113798277	Missense_Mutation	NA	R442H	0.22
UCEC	chr3	113781133	Nonsense_Mutation	novel	R56*	0.13
UCEC	chr3	113811606	3'UTR	novel		0.09
UCEC	chr3	113794952	Missense_Mutation	novel	A357T	0.43
UCEC	chr3	113786383	Missense_Mutation	rs753834280	P239L	0.09
UCEC	chr3	113784373	Missense_Mutation	NA	G121R	0.38
UCEC	chr3	113786384	Splice_Site	rs755278709	X239_splice	0.44
UCEC	chr3	113784743	Silent	NA	E158E	0.19
UCEC	chr3	113812047	3'UTR	novel		0.35
UCEC	chr3	113784381	Silent	rs138089165	N123N	0.17
UCEC	chr3	113784749	Silent	rs766110305	S160S	0.22
UCEC	chr3	113788719	Silent	novel	V241V	0.28
UCEC	chr3	113788860	Silent	novel	L288L	0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
GBM	DEL	0.0797	0.00094652
KIRC	DEL	0.2367	0.11092
LGG	DEL	0.0643	0.04374

Survival Analysis

Cancer	P-value	Q-value
THYM	0.017	Kaplan-Meier Survival Analysis
KIRC	0.00011	Kaplan-Meier Survival Analysis
MESO	0.0037	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
PRAD	0.014	Kaplan-Meier Survival Analysis
LUSC	0.046	Kaplan-Meier Survival Analysis
TGCT	0.039	Kaplan-Meier Survival Analysis
PAAD	0.021	Kaplan-Meier Survival Analysis
PCPG	0.034	Kaplan-Meier Survival Analysis
LAML	0.015	Kaplan-Meier Survival Analysis
UCEC	0.028	Kaplan-Meier Survival Analysis
LIHC	0.049	Kaplan-Meier Survival Analysis
LGG	0.00056	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000114573 (Gene tree)
Gene ID: 523
Gene Symbol: ATP6V1A
Alias: Vma1|VA68|VPP2|ATP6A1|ATP6V1A1
Full Name: ATPase H+ transporting V1 subunit A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 65,040 bases
Position: chr3:113,747,019-113,812,058
Accession: 851
RBP type: non-canonical RBP
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c\, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30917721	Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.	Autophagy	2019 Sep	Fernandez-Mosquera L	doi: 10.1080/15548627.2019.1586256

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000461496	ATP6V1A-202	542	-	-	- (aa)	-	-
ENST00000496747	ATP6V1A-206	710	-	ENSP00000417545	184 (aa)	-	C9JA17
ENST00000470455	ATP6V1A-204	2266	-	ENSP00000420146	49 (aa)	-	F8WDJ3
ENST00000475322	ATP6V1A-205	754	-	ENSP00000419294	221 (aa)	-	C9JVW8
ENST00000273398	ATP6V1A-201	4591	-	ENSP00000273398	617 (aa)	-	P38606
ENST00000462855	ATP6V1A-203	509	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000114573's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00190	Oxidative phosphorylation	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04145	Phagosome	KEGG
hsa04150	mTOR signaling pathway	KEGG
hsa04721	Synaptic vesicle cycle	KEGG
hsa04966	Collecting duct acid secretion	KEGG
hsa05110	Vibrio cholerae infection	KEGG
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	KEGG
hsa05165	Human papillomavirus infection	KEGG
hsa05323	Rheumatoid arthritis	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000114573	rs2465281	3	113782573	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000114573's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000114573	ATP6V1A	98	81.592	WBGene00013025	vha-13	99	81.592	Caenorhabditis_elegans
ENSG00000114573	ATP6V1A	100	98.055	ENSMUSG00000052459	Atp6v1a	100	98.701	Mus_musculus
ENSG00000114573	ATP6V1A	100	66.486	YDL185W	VMA1	60	65.320	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005524	ATP binding	-	IEA	Function
GO:0005765	lysosomal membrane	17897319.	HDA	Component
GO:0005774	vacuolar membrane	21873635.	IBA	Component
GO:0005829	cytosol	-	ISS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	-	ISS	Component
GO:0005886	plasma membrane	8463241.	TAS	Component
GO:0005902	microvillus	-	IEA	Component
GO:0006879	cellular iron ion homeostasis	28296633.	IMP	Process
GO:0008286	insulin receptor signaling pathway	-	TAS	Process
GO:0015991	ATP hydrolysis coupled proton transport	-	IEA	Process
GO:0016241	regulation of macroautophagy	22982048.	NAS	Process
GO:0016324	apical plasma membrane	-	IEA	Component
GO:0016469	proton-transporting two-sector ATPase complex	8463241.	TAS	Component
GO:0033180	proton-transporting V-type ATPase, V1 domain	-	IEA	Component
GO:0033572	transferrin transport	-	TAS	Process
GO:0034220	ion transmembrane transport	-	TAS	Process
GO:0036295	cellular response to increased oxygen levels	28296633.	IMP	Process
GO:0046034	ATP metabolic process	-	IEA	Process
GO:0046961	proton-transporting ATPase activity, rotational mechanism	21873635.	IBA	Function
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0090383	phagosome acidification	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.