EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr351934533Missense_MutationnovelV400A0.74
BLCAchr351934718Missense_MutationnovelH365Y0.33
BLCAchr351937668Splice_Siters776825150X116_splice0.27
BLCAchr351934514SilentnovelG406G0.31
BLCAchr351933517Missense_MutationNAA473T0.22
BLCAchr351933761SilentnovelL427L0.52
BLCAchr351933496Missense_Mutationnovel0.39
BRCAchr351935364Nonsense_MutationNAQ317*0.58
CESCchr351937251Missense_MutationnovelV153A0.36
CESCchr351936536SilentNAR179R0.38
CESCchr351933542SilentNAL464L0.38
CESCchr351935635Missense_Mutationrs147742914V265M0.14
COADchr351936446In_Frame_DelNAS209del0.41
COADchr351934760Missense_MutationNAG351C0.19
COADchr351934664Missense_MutationNAA383T0.36
COADchr351935453Missense_MutationnovelA287D0.18
COADchr351936337Missense_Mutationrs143989805R219C0.29
COADchr351934664Missense_MutationNAA383T0.19
COADchr351936270Missense_Mutationrs376861276R241Q0.32
COADchr351941435In_Frame_Delrs774248694E48del0.32
COADchr351937256Missense_MutationnovelC151W0.79
COADchr351936555Missense_MutationnovelW173L0.31
GBMchr351941417Missense_MutationnovelE54D0.25
KIRCchr351937244SilentNAT155T0.37
LIHCchr351935455SilentNAV286V0.4
LIHCchr351936348Missense_MutationnovelA215G0.42
LUADchr351933770Missense_MutationnovelI424M0.04
LUADchr351935205Silentrs372990572A342A0.28
LUADchr351934705Missense_MutationNAG369A0.64
LUADchr351938136Missense_MutationNAL80Q0.57
LUADchr351937210Missense_Mutationrs750834054D167N0.4
LUADchr351937690SilentnovelA109A0.56
LUSCchr351933568SilentNAR456R0.48
LUSCchr351938196Missense_MutationnovelP60L0.67
LUSCchr351936519Missense_Mutationrs146452464P185L0.33
LUSCchr3519334533'UTRnovel0.5
OVchr351941447Missense_MutationNAK44N0.47
OVchr351935385Missense_MutationnovelW310G0.14
READchr3519334453'UTRnovel0.5
READchr351938136Missense_MutationnovelL80P0.36
SKCMchr351934756Frame_Shift_DelnovelL352Pfs*890.28
SKCMchr351934656SilentNAL385L0.54
SKCMchr351933568Missense_MutationNAR456W0.46
SKCMchr351935353SilentNAF320F0.33
SKCMchr351937250Silentrs745635865V153V0.24
SKCMchr351937223SilentNAF162F0.49
SKCMchr351933541Missense_Mutationrs760648950R465C0.34
SKCMchr351935211Silentrs377278868S340S0.3
SKCMchr351937266Missense_MutationNAS148F0.17
SKCMchr351935641Missense_Mutationrs140029162R263C0.28
SKCMchr351933737SilentNAF435F0.18
SKCMchr351933510Missense_MutationNAS475F0.45
STADchr351934503Missense_MutationNAR410Q0.23
STADchr351936469Missense_MutationNAV202I0.32
STADchr351934504Missense_Mutationrs745791944R410W0.4
STADchr351935236Missense_MutationnovelL332P0.3
STADchr351935641Missense_Mutationrs140029162R263C0.34
STADchr351936271Missense_MutationNAR241W0.16
THCAchr351935472Missense_MutationNAG281R0.25
UCECchr351936545SilentNAE176E0.33
UCECchr351935679Missense_Mutationrs151070017R250H0.13
UCECchr351934716Silentrs747276295H365H0.36
UCECchr351938127Missense_MutationnovelA83V0.22
UCECchr351935249Missense_Mutationrs374259830D328N0.23
UCECchr351935612SilentNAE272E0.24
UCECchr351937565Nonsense_MutationNAQ124*0.27
UCECchr351935640Missense_MutationnovelR263H0.19
UCECchr351936470Silentrs147286318H201H0.18
UCECchr351937670Missense_MutationNAV116A0.26
UCECchr351936537Missense_MutationnovelR179Q0.5
UCECchr351935472Missense_MutationNAG281R0.42
UCECchr351936441Missense_MutationnovelG211D0.35
UCECchr351933593SilentNAG447G0.37
UCECchr351935598Missense_MutationnovelE277V0.49
UCECchr351937287Missense_MutationnovelV141A0.45
UCECchr351935452SilentnovelA287A0.29
UCECchr351937290Missense_Mutationrs113804016R140H0.18
UCECchr351935640Missense_MutationnovelR263H0.4
UCECchr351936538Missense_Mutationrs372092049R179W0.56
UCECchr351935207Missense_Mutationrs144222078A342T0.45
UCECchr351937241SilentnovelP156P0.32
UCECchr351938133Missense_Mutationrs769929770R81H0.6
UCECchr351933540Missense_MutationnovelR465H0.21
UCECchr351936551SilentnovelS174S0.35
UCECchr351937202SilentnovelS169S0.07
UCECchr351936443Silentrs143950192D210D0.28

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CHOLDEL0.77780.016387
GBMDEL0.08150.056565
LGGDEL0.08190.00089193
LUADDEL0.32950.0021265
PAADDEL0.18480.030662
SARCDEL0.22180.0034746
SKCMDEL0.16620.13887
TGCTAMP0.14670.23596
THYMDEL0.08130.037527

Survival Analysis
CancerP-value Q-value
THYM0.029

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.00091

Kaplan-Meier Survival Analysis

ACC0.00017

Kaplan-Meier Survival Analysis

UCS0.035

Kaplan-Meier Survival Analysis

SKCM0.02

Kaplan-Meier Survival Analysis

PRAD0.017

Kaplan-Meier Survival Analysis

LAML0.0079

Kaplan-Meier Survival Analysis

LIHC0.00059

Kaplan-Meier Survival Analysis

DLBC0.02

Kaplan-Meier Survival Analysis

THCA0.028

Kaplan-Meier Survival Analysis

UVM0.00013

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000114767 (Gene tree)
Gene ID
9136
Gene Symbol
RRP9
Alias
U3-55K|RNU3IP2
Full Name
ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
8,516 bases
Position
chr3:51,933,426-51,941,941
Accession
16829
RBP type
non-canonical RBP
Summary
This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). [provided by RefSeq, Oct 2012]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
10982864Interaction of the U3-55k protein with U3 snoRNA is mediated by the box B/C motif of U3 and the WD repeats of U3-55k.Nucleic Acids Res2000 Sep 15Lukowiak AA-
12381732The hU3-55K protein requires 15.5K binding to the box B/C motif as well as flanking RNA elements for its association with the U3 small nucleolar RNA in Vitro.J Biol Chem2002 Dec 13Granneman S-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000232888RRP9-2011578-ENSP00000232888475 (aa)-O43818
Gene Model
Click here to download ENSG00000114767's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000114767E-Selectin3.7883000E-00519729612
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000114767's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000114767RRP98844.213FBgn0053505U3-55K8045.316Drosophila_melanogaster
ENSG00000114767RRP910092.632ENSMUSG00000041506Rrp910092.632Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus9418896.IDAComponent
GO:0006364rRNA processing9418896.ICProcess
GO:0006364rRNA processing-TASProcess
GO:0031428box C/D snoRNP complex9418896.IDAComponent
GO:0032040small-subunit processome21873635.IBAComponent
GO:0034511U3 snoRNA binding9418896.IDAFunction
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